RANBP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)8.95824090
2protoporphyrinogen IX biosynthetic process (GO:0006782)7.91106972
3porphyrin-containing compound biosynthetic process (GO:0006779)6.02394123
4oxygen transport (GO:0015671)5.81854475
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.45275709
6L-phenylalanine catabolic process (GO:0006559)5.45275709
7tetrapyrrole biosynthetic process (GO:0033014)5.34446646
8porphyrin-containing compound metabolic process (GO:0006778)5.24438315
9gas transport (GO:0015669)5.22567390
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.19953876
11L-phenylalanine metabolic process (GO:0006558)5.19953876
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.15478577
13negative regulation of erythrocyte differentiation (GO:0045647)5.15197281
14heme biosynthetic process (GO:0006783)5.12823802
15aromatic amino acid family catabolic process (GO:0009074)5.05273045
16cysteine metabolic process (GO:0006534)5.04786947
17very-low-density lipoprotein particle assembly (GO:0034379)5.03034636
18plasma lipoprotein particle assembly (GO:0034377)4.93524535
19kynurenine metabolic process (GO:0070189)4.89919083
20alpha-linolenic acid metabolic process (GO:0036109)4.77366930
21indole-containing compound catabolic process (GO:0042436)4.76161974
22indolalkylamine catabolic process (GO:0046218)4.76161974
23tryptophan catabolic process (GO:0006569)4.76161974
24urea cycle (GO:0000050)4.75184974
25urea metabolic process (GO:0019627)4.75184974
26hemoglobin metabolic process (GO:0020027)4.68045551
27negative regulation of fibrinolysis (GO:0051918)4.66876438
28protein-lipid complex assembly (GO:0065005)4.60203452
29heme metabolic process (GO:0042168)4.53313938
30response to methylmercury (GO:0051597)4.53186454
31peptidyl-glutamic acid carboxylation (GO:0017187)4.51310345
32protein carboxylation (GO:0018214)4.51310345
33tryptophan metabolic process (GO:0006568)4.47360665
34regulation of protein activation cascade (GO:2000257)4.39532027
35nitrogen cycle metabolic process (GO:0071941)4.34784928
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.34603960
37lysine catabolic process (GO:0006554)4.33552190
38lysine metabolic process (GO:0006553)4.33552190
39serine family amino acid catabolic process (GO:0009071)4.29451928
40glyoxylate metabolic process (GO:0046487)4.28228980
41complement activation, alternative pathway (GO:0006957)4.28045833
42high-density lipoprotein particle remodeling (GO:0034375)4.27822032
43bile acid biosynthetic process (GO:0006699)4.24400517
44regulation of fibrinolysis (GO:0051917)4.23934243
453-UTR-mediated mRNA stabilization (GO:0070935)4.17795445
46phospholipid efflux (GO:0033700)4.12923551
47regulation of complement activation (GO:0030449)4.10956266
48regulation of triglyceride catabolic process (GO:0010896)4.06560447
49regulation of response to osmotic stress (GO:0047484)4.06029659
50amino-acid betaine metabolic process (GO:0006577)4.01845211
51sulfur amino acid catabolic process (GO:0000098)4.01739378
52intracellular estrogen receptor signaling pathway (GO:0030520)4.01000533
53homocysteine metabolic process (GO:0050667)3.94625775
54erythrocyte maturation (GO:0043249)3.93766363
55cholesterol efflux (GO:0033344)3.89236197
56negative regulation of cholesterol transport (GO:0032375)3.88658205
57negative regulation of sterol transport (GO:0032372)3.88658205
58regulation of cholesterol homeostasis (GO:2000188)3.86356538
59reverse cholesterol transport (GO:0043691)3.85161433
60glycine metabolic process (GO:0006544)3.84635464
61plasma lipoprotein particle clearance (GO:0034381)3.79428751
62plasma lipoprotein particle organization (GO:0071827)3.73750730
63bile acid metabolic process (GO:0008206)3.71010867
64dicarboxylic acid biosynthetic process (GO:0043650)3.69110169
65triglyceride homeostasis (GO:0070328)3.68700652
66acylglycerol homeostasis (GO:0055090)3.68700652
67protein-lipid complex remodeling (GO:0034368)3.63913146
68macromolecular complex remodeling (GO:0034367)3.63913146
69plasma lipoprotein particle remodeling (GO:0034369)3.63913146
70detection of bacterium (GO:0016045)3.63011611
71protein-lipid complex subunit organization (GO:0071825)3.62130347
72regulation of cholesterol esterification (GO:0010872)3.58934966
73detection of other organism (GO:0098543)3.55489838
74aromatic amino acid family metabolic process (GO:0009072)3.53099996
75serine family amino acid metabolic process (GO:0009069)3.52287513
76phospholipid homeostasis (GO:0055091)3.51146157
77glutamate metabolic process (GO:0006536)3.50495058
78alpha-amino acid catabolic process (GO:1901606)3.50389790
79heme transport (GO:0015886)3.50060938
80positive regulation of lipid catabolic process (GO:0050996)3.47537745
81positive regulation of fatty acid beta-oxidation (GO:0032000)3.44613097
82response to arsenic-containing substance (GO:0046685)3.43254571
83histone H3-K36 demethylation (GO:0070544)3.42988436
84modulation by virus of host process (GO:0019054)3.41130799
85negative regulation of fatty acid biosynthetic process (GO:0045717)3.40105254
86tetrapyrrole metabolic process (GO:0033013)3.39275384
87imidazole-containing compound metabolic process (GO:0052803)3.38694077
88mannose metabolic process (GO:0006013)3.36688367
89ethanol oxidation (GO:0006069)3.35269703
90myeloid cell development (GO:0061515)3.34742275
91response to lead ion (GO:0010288)3.33261695
92tyrosine metabolic process (GO:0006570)3.33052483
93bile acid and bile salt transport (GO:0015721)3.32926469
94fibrinolysis (GO:0042730)3.26741849
95L-alpha-amino acid transmembrane transport (GO:1902475)3.25138381
96regulation of fatty acid beta-oxidation (GO:0031998)3.19716210
97positive regulation of lipoprotein lipase activity (GO:0051006)3.19151106
98positive regulation of triglyceride lipase activity (GO:0061365)3.19151106
99arginine metabolic process (GO:0006525)3.18770253
100cellular biogenic amine catabolic process (GO:0042402)3.17768809
101amine catabolic process (GO:0009310)3.17768809
102positive regulation of gamma-delta T cell activation (GO:0046645)3.17523076
1032-oxoglutarate metabolic process (GO:0006103)3.16370048
104cholesterol homeostasis (GO:0042632)3.16112759
105indolalkylamine metabolic process (GO:0006586)3.15089282
106carnitine metabolic process (GO:0009437)3.14388834
107cellular amino acid catabolic process (GO:0009063)3.12865721
108sterol homeostasis (GO:0055092)3.12248675
109modulation by symbiont of host cellular process (GO:0044068)3.11595002
110erythrocyte development (GO:0048821)3.10900144
111regulation of cytokine secretion involved in immune response (GO:0002739)3.08431690
112positive regulation of triglyceride metabolic process (GO:0090208)3.06940979
113cellular response to virus (GO:0098586)3.05710056
114cofactor catabolic process (GO:0051187)3.05140074
115cellular modified amino acid catabolic process (GO:0042219)3.03471756
116positive regulation of granulocyte differentiation (GO:0030854)3.00975153
117regulation of chromatin binding (GO:0035561)3.00495533
118regulation of histone H3-K27 methylation (GO:0061085)2.93365693
119histone H3-K9 demethylation (GO:0033169)2.92666416
120detection of external biotic stimulus (GO:0098581)2.90051785
121megakaryocyte development (GO:0035855)2.86813664
122histone H4 deacetylation (GO:0070933)2.84604047
123regulation of RNA export from nucleus (GO:0046831)2.84501929
124modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.81642672
125positive regulation by organism of defense response of other organism involved in symbiotic interact2.81642672
126modulation by symbiont of host immune response (GO:0052553)2.81642672
127positive regulation by symbiont of host defense response (GO:0052509)2.81642672
128modulation by symbiont of host defense response (GO:0052031)2.81642672
129modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.81642672
130definitive hemopoiesis (GO:0060216)2.80072990
131histone lysine demethylation (GO:0070076)2.78776266
132positive regulation of Cdc42 GTPase activity (GO:0043089)2.77863428
133antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77671000
134regulation of granulocyte differentiation (GO:0030852)2.77626206
135negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.76101243
136negative regulation of cell killing (GO:0031342)2.76101243
137cellular hyperosmotic response (GO:0071474)2.74952586
138positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.72788270
139response to muramyl dipeptide (GO:0032495)2.72546927
140negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.71526556
141regulation of gamma-delta T cell activation (GO:0046643)2.69016077
142regulation of gamma-delta T cell differentiation (GO:0045586)2.67350918
143response to mercury ion (GO:0046689)2.64422669
144regulation of nucleobase-containing compound transport (GO:0032239)2.62649310
145histone demethylation (GO:0016577)2.62217634
146response to peptidoglycan (GO:0032494)2.58937693
147regulation of NFAT protein import into nucleus (GO:0051532)2.57373663
148phosphatidylethanolamine biosynthetic process (GO:0006646)2.55092828
149granulocyte differentiation (GO:0030851)2.55028602
150thymic T cell selection (GO:0045061)2.54016828
151positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.53723627
152embryonic process involved in female pregnancy (GO:0060136)2.53619218
153regulation of ARF GTPase activity (GO:0032312)2.52611568
154antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.50548879
155positive thymic T cell selection (GO:0045059)2.49573211
156modulation by virus of host morphology or physiology (GO:0019048)2.49497347
157regulation of ARF protein signal transduction (GO:0032012)2.47174807
158response to laminar fluid shear stress (GO:0034616)2.46855343
159regulation of necroptotic process (GO:0060544)2.45171359
160detection of biotic stimulus (GO:0009595)2.44996727
161regulation of leukocyte degranulation (GO:0043300)2.44112324
162negative regulation of granulocyte differentiation (GO:0030853)2.43546919
163negative regulation of necroptotic process (GO:0060546)2.41030275
164germinal center formation (GO:0002467)2.40425760
165regulation of myeloid leukocyte mediated immunity (GO:0002886)2.38430579
166antigen processing and presentation of endogenous antigen (GO:0019883)2.38319238
167killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.38258903
168disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.38258903
169regulation of erythrocyte differentiation (GO:0045646)2.37875291
170regulation of mast cell degranulation (GO:0043304)2.37188600
171negative regulation of myotube differentiation (GO:0010832)2.36880415
172platelet formation (GO:0030220)2.36311160
173cytoskeletal anchoring at plasma membrane (GO:0007016)2.36033963
174leukocyte aggregation (GO:0070486)2.35398245
175negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.35054523
176positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.34100177
177mRNA stabilization (GO:0048255)2.33473870
178RNA stabilization (GO:0043489)2.33473870
179protein targeting to plasma membrane (GO:0072661)2.33203126
180Peyers patch development (GO:0048541)2.32734716
181mucosal-associated lymphoid tissue development (GO:0048537)2.32734716

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.59168331
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.48067506
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.02092610
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.37627579
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.33177456
6GATA1_22025678_ChIP-Seq_K562_Human3.72757306
7* FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.20491675
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.18227401
9GATA1_19941826_ChIP-Seq_K562_Human3.09342294
10* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.98846649
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.87876824
12* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.86297619
13TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.63496655
14* GATA1_19941827_ChIP-Seq_MEL_Mouse2.54505977
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.22257888
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21214686
17SCL_19346495_ChIP-Seq_HPC-7_Human2.14761877
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.14710435
19* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.08620009
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04635759
21GATA2_19941826_ChIP-Seq_K562_Human1.93360122
22ZNF263_19887448_ChIP-Seq_K562_Human1.92771629
23MYC_22102868_ChIP-Seq_BL_Human1.91083246
24KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.86821456
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83557720
26GATA1_22383799_ChIP-Seq_G1ME_Mouse1.66202178
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66064985
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65622099
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63493853
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61565329
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59288501
32SMC4_20622854_ChIP-Seq_HELA_Human1.59079902
33CLOCK_20551151_ChIP-Seq_293T_Human1.57739898
34TCF7_22412390_ChIP-Seq_EML_Mouse1.57141866
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56417950
36TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.54555549
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52609194
38SPI1_23127762_ChIP-Seq_K562_Human1.49959740
39* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44343601
40KDM2B_26808549_Chip-Seq_DND41_Human1.41686145
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41447176
42SA1_27219007_Chip-Seq_ERYTHROID_Human1.40194520
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.37743684
44GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36425750
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36110297
46* VDR_21846776_ChIP-Seq_THP-1_Human1.34332203
47MAF_26560356_Chip-Seq_TH1_Human1.33732014
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32403432
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.31164350
50NCOR1_26117541_ChIP-Seq_K562_Human1.30481935
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.30078454
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.27786025
53* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27441878
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24448983
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23601531
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21236347
57* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21040322
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20314580
59RUNX1_27514584_Chip-Seq_MCF-7_Human1.18414589
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.18293692
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17216084
62LXR_22292898_ChIP-Seq_THP-1_Human1.16935627
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16894138
64* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16694872
65UTX_26944678_Chip-Seq_JUKART_Human1.15668986
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15324944
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15214660
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13051173
69BCL6_27268052_Chip-Seq_Bcells_Human1.12368749
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11820424
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10762968
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10028400
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09238479
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09215196
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07764846
76CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07213915
77GATA6_25053715_ChIP-Seq_YYC3_Human1.03774837
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03169112
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02856309
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.01706608
81RACK7_27058665_Chip-Seq_MCF-7_Human1.01665708
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01413528
83* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01039872
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01014038
85P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00517381
86ATF3_27146783_Chip-Seq_COLON_Human0.99453201
87RUNX_20019798_ChIP-Seq_JUKART_Human0.98612384
88FOXO3_23340844_ChIP-Seq_DLD1_Human0.98501987
89IRF8_27001747_Chip-Seq_BMDM_Mouse0.98453919
90* HNF4A_19822575_ChIP-Seq_HepG2_Human0.98153867
91* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98109947
92E2F7_22180533_ChIP-Seq_HELA_Human0.98089969
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97049749
94PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96898572
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96861408
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96848035
97* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96349860
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96062322
99RUNX1_22412390_ChIP-Seq_EML_Mouse0.96003038
100CIITA_25753668_ChIP-Seq_RAJI_Human0.95079211
101MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95012840
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94978628
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94907015
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94417345
105SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93836266
106ELF1_20517297_ChIP-Seq_JURKAT_Human0.92399116
107KDM2B_26808549_Chip-Seq_K562_Human0.92287223
108IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91952953
109SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.91516922
110RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90681126
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89902867
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88784092
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88779996
114CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87821992
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87357858
116* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87094474
117FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86953901
118KDM2B_26808549_Chip-Seq_JURKAT_Human0.85608498
119CREB1_26743006_Chip-Seq_LNCaP_Human0.84488910
120ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84445417
121BCOR_27268052_Chip-Seq_Bcells_Human0.81539223
122MYB_26560356_Chip-Seq_TH1_Human0.80749034
123MAF_26560356_Chip-Seq_TH2_Human0.79865921
124P68_20966046_ChIP-Seq_HELA_Human0.79683766
125VDR_24763502_ChIP-Seq_THP-1_Human0.79249712
126ESR2_21235772_ChIP-Seq_MCF-7_Human0.79121680
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78549914
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77555211
129FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.76969170
130EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.76237363
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74138961
132GATA4_25053715_ChIP-Seq_YYC3_Human0.73824803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.19369984
2MP0003656_abnormal_erythrocyte_physiolo6.10524655
3MP0005360_urolithiasis5.45274893
4MP0005085_abnormal_gallbladder_physiolo4.69220830
5MP0005365_abnormal_bile_salt4.42357007
6MP0005083_abnormal_biliary_tract4.08144429
7MP0004147_increased_porphyrin_level3.52022451
8MP0008875_abnormal_xenobiotic_pharmacok3.29695706
9MP0008260_abnormal_autophagy3.29039168
10MP0009840_abnormal_foam_cell3.05965430
11MP0003252_abnormal_bile_duct2.88282780
12MP0010329_abnormal_lipoprotein_level2.83972996
13MP0003705_abnormal_hypodermis_morpholog2.71801328
14MP0003806_abnormal_nucleotide_metabolis2.66342281
15MP0003172_abnormal_lysosome_physiology2.64740348
16MP0003191_abnormal_cellular_cholesterol2.32033748
17MP0000609_abnormal_liver_physiology2.22361142
18MP0001666_abnormal_nutrient_absorption1.87697593
19MP0001849_ear_inflammation1.75913426
20MP0004381_abnormal_hair_follicle1.72943026
21MP0002138_abnormal_hepatobiliary_system1.69942758
22MP0005332_abnormal_amino_acid1.69267702
23MP0002118_abnormal_lipid_homeostasis1.65064683
24MP0003763_abnormal_thymus_physiology1.61644275
25MP0005025_abnormal_response_to1.58879790
26MP0005319_abnormal_enzyme/_coenzyme1.55557533
27MP0002419_abnormal_innate_immunity1.50581011
28MP0005409_darkened_coat_color1.48103309
29MP0005464_abnormal_platelet_physiology1.47361423
30MP0002396_abnormal_hematopoietic_system1.44249404
31MP0003300_gastrointestinal_ulcer1.37166584
32MP0001545_abnormal_hematopoietic_system1.36908723
33MP0005397_hematopoietic_system_phenotyp1.36908723
34MP0009333_abnormal_splenocyte_physiolog1.35718428
35MP0000598_abnormal_liver_morphology1.34006980
36MP0001790_abnormal_immune_system1.33004436
37MP0005387_immune_system_phenotype1.33004436
38MP0003868_abnormal_feces_composition1.30552324
39MP0002249_abnormal_larynx_morphology1.29826260
40MP0001348_abnormal_lacrimal_gland1.29780717
41MP0003195_calcinosis1.26698760
42MP0000703_abnormal_thymus_morphology1.25954925
43MP0005451_abnormal_body_composition1.24499226
44MP0001800_abnormal_humoral_immune1.24386895
45MP0004019_abnormal_vitamin_homeostasis1.23510755
46MP0002653_abnormal_ependyma_morphology1.20057310
47MP0005636_abnormal_mineral_homeostasis1.18856923
48MP0005670_abnormal_white_adipose1.18594718
49MP0002254_reproductive_system_inflammat1.16481190
50MP0001851_eye_inflammation1.15442865
51MP0003828_pulmonary_edema1.13911595
52MP0005584_abnormal_enzyme/coenzyme_acti1.11421742
53MP0002822_catalepsy1.11126437
54MP0003436_decreased_susceptibility_to1.10895460
55MP0003878_abnormal_ear_physiology1.10440921
56MP0005377_hearing/vestibular/ear_phenot1.10440921
57MP0010307_abnormal_tumor_latency1.09747029
58MP0009763_increased_sensitivity_to1.09239478
59MP0002420_abnormal_adaptive_immunity1.08121100
60MP0004185_abnormal_adipocyte_glucose1.07332360
61MP0003091_abnormal_cell_migration1.07292957
62MP0009764_decreased_sensitivity_to1.06849125
63MP0001819_abnormal_immune_cell1.06055463
64MP0004130_abnormal_muscle_cell1.05831910
65MP0005000_abnormal_immune_tolerance1.05483004
66MP0009643_abnormal_urine_homeostasis1.04710925
67MP0000685_abnormal_immune_system1.04129994
68MP0000716_abnormal_immune_system1.02772290
69MP0010155_abnormal_intestine_physiology1.01982313
70MP0000858_altered_metastatic_potential1.01260964
71MP0001835_abnormal_antigen_presentation1.00419312
72MP0002971_abnormal_brown_adipose0.96930004
73MP0005075_abnormal_melanosome_morpholog0.96815952
74MP0002723_abnormal_immune_serum0.96608888
75MP0003303_peritoneal_inflammation0.96414048
76MP0000678_abnormal_parathyroid_gland0.95617202
77MP0004947_skin_inflammation0.95554411
78MP0004858_abnormal_nervous_system0.95433517
79MP0002009_preneoplasia0.95047798
80MP0009785_altered_susceptibility_to0.93591210
81MP0000015_abnormal_ear_pigmentation0.91249636
82MP0002452_abnormal_antigen_presenting0.90991999
83MP0004233_abnormal_muscle_weight0.90976383
84MP0005621_abnormal_cell_physiology0.90106869
85MP0009278_abnormal_bone_marrow0.89834339
86MP0003724_increased_susceptibility_to0.88016810
87MP0000604_amyloidosis0.87413217
88MP0005076_abnormal_cell_differentiation0.87050263
89MP0005666_abnormal_adipose_tissue0.86991660
90MP0003111_abnormal_nucleus_morphology0.86792077
91MP0003566_abnormal_cell_adhesion0.85892784
92MP0008469_abnormal_protein_level0.85775998
93MP0001764_abnormal_homeostasis0.81282218
94MP0009765_abnormal_xenobiotic_induced0.80176690
95MP0005334_abnormal_fat_pad0.79460768
96MP0002796_impaired_skin_barrier0.78556698
97MP0009931_abnormal_skin_appearance0.78518497
98MP0005647_abnormal_sex_gland0.78307310
99MP0010368_abnormal_lymphatic_system0.78036486
100MP0001533_abnormal_skeleton_physiology0.76930178
101MP0003186_abnormal_redox_activity0.76759007
102MP0003453_abnormal_keratinocyte_physiol0.76227600
103MP0002998_abnormal_bone_remodeling0.75988544
104MP0004883_abnormal_blood_vessel0.75877066
105MP0009053_abnormal_anal_canal0.73842584
106MP0006036_abnormal_mitochondrial_physio0.71389341
107MP0000689_abnormal_spleen_morphology0.71310542
108MP0003183_abnormal_peptide_metabolism0.70462248
109MP0005058_abnormal_lysosome_morphology0.69817221
110MP0009672_abnormal_birth_weight0.68071602
111MP0005023_abnormal_wound_healing0.67853535
112MP0005408_hypopigmentation0.67587861
113MP0009642_abnormal_blood_homeostasis0.67567464
114MP0008995_early_reproductive_senescence0.67303954
115MP0002722_abnormal_immune_system0.67178282
116MP0005501_abnormal_skin_physiology0.66855301
117MP0004510_myositis0.66435028
118MP0002970_abnormal_white_adipose0.66415084
119MP0005248_abnormal_Harderian_gland0.65528487
120MP0000371_diluted_coat_color0.64844448
121MP0002060_abnormal_skin_morphology0.64691004
122MP0008775_abnormal_heart_ventricle0.64483065
123MP0008874_decreased_physiological_sensi0.63848173
124MP0000747_muscle_weakness0.63727651
125MP0008770_decreased_survivor_rate0.63668733
126MP0002398_abnormal_bone_marrow0.63027597
127MP0002166_altered_tumor_susceptibility0.61360447
128MP0006082_CNS_inflammation0.60359852
129MP0002136_abnormal_kidney_physiology0.60049069
130MP0005167_abnormal_blood-brain_barrier0.58941970
131MP0002086_abnormal_extraembryonic_tissu0.58850686
132MP0001756_abnormal_urination0.58611217
133MP0010352_gastrointestinal_tract_polyps0.58565005
134MP0002877_abnormal_melanocyte_morpholog0.57552137
135MP0002078_abnormal_glucose_homeostasis0.57466936
136MP0009115_abnormal_fat_cell0.55644527
137MP0001243_abnormal_dermal_layer0.55317645
138MP0001915_intracranial_hemorrhage0.55267845
139MP0002269_muscular_atrophy0.54106138
140MP0002429_abnormal_blood_cell0.52384181
141MP0008961_abnormal_basal_metabolism0.51302071
142MP0010630_abnormal_cardiac_muscle0.50603507
143MP0004808_abnormal_hematopoietic_stem0.50513929
144MP0005375_adipose_tissue_phenotype0.50386535
145MP0002132_abnormal_respiratory_system0.49870698
146MP0001845_abnormal_inflammatory_respons0.49726977
147MP0005448_abnormal_energy_balance0.48230458
148MP0001853_heart_inflammation0.48093802
149MP0002088_abnormal_embryonic_growth/wei0.45993023
150MP0004264_abnormal_extraembryonic_tissu0.45364389
151MP0008872_abnormal_physiological_respon0.45254867
152MP0002405_respiratory_system_inflammati0.44092625

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)8.33953633
2Hypochromic microcytic anemia (HP:0004840)6.38622453
3Acanthocytosis (HP:0001927)6.05915411
4Abnormality of the heme biosynthetic pathway (HP:0010472)5.81603730
5Reticulocytosis (HP:0001923)5.79839234
6Deep venous thrombosis (HP:0002625)5.64275506
7Cholelithiasis (HP:0001081)5.15334071
8Xanthomatosis (HP:0000991)4.84514373
9Intrahepatic cholestasis (HP:0001406)4.79808187
10Abnormal gallbladder morphology (HP:0012437)4.73316140
11Abnormality of monocarboxylic acid metabolism (HP:0010996)4.63861657
12Hyperbilirubinemia (HP:0002904)4.60941863
13Abnormality of aromatic amino acid family metabolism (HP:0004338)4.35959770
14Complement deficiency (HP:0004431)4.17050044
15Hyperlipoproteinemia (HP:0010980)4.00496336
16Prolonged partial thromboplastin time (HP:0003645)3.96598259
17Hypobetalipoproteinemia (HP:0003563)3.93039552
18Hepatocellular carcinoma (HP:0001402)3.67719843
19Hypoalphalipoproteinemia (HP:0003233)3.53151686
20Joint hemorrhage (HP:0005261)3.45605749
21Hypolipoproteinemia (HP:0010981)3.43136480
22Polycythemia (HP:0001901)3.43064714
23Abnormality of the gallbladder (HP:0005264)3.41290850
24Eczematoid dermatitis (HP:0000976)3.38240944
25Myocardial infarction (HP:0001658)3.36040369
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.33217771
27Abnormality of reticulocytes (HP:0004312)3.26277139
28Abnormality of the common coagulation pathway (HP:0010990)3.24159862
29Hypochromic anemia (HP:0001931)3.20530768
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.17256890
31Abnormality of complement system (HP:0005339)3.17216290
32Epidermoid cyst (HP:0200040)3.15430151
33Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.15402321
34Cholecystitis (HP:0001082)3.09010601
35Abnormal gallbladder physiology (HP:0012438)3.09010601
36Diaphragmatic weakness (HP:0009113)3.03549392
37Paralysis (HP:0003470)3.00086893
38Hyperammonemia (HP:0001987)2.99247004
39Hypercholesterolemia (HP:0003124)2.94978424
40Obstructive sleep apnea (HP:0002870)2.88223772
41Abnormal hemoglobin (HP:0011902)2.79579980
42Global brain atrophy (HP:0002283)2.72817725
43Microcytic anemia (HP:0001935)2.70453568
44Increased IgE level (HP:0003212)2.66633640
45Pustule (HP:0200039)2.66628817
46Abnormality of glutamine family amino acid metabolism (HP:0010902)2.65674446
47Hyperglycinemia (HP:0002154)2.65141716
48Ketosis (HP:0001946)2.64851388
49Abnormality of pyrimidine metabolism (HP:0004353)2.64728481
50Cellulitis (HP:0100658)2.61224606
51Nasal polyposis (HP:0100582)2.60893567
52Abnormality of iron homeostasis (HP:0011031)2.59618281
53Abnormality of the intrinsic pathway (HP:0010989)2.58689524
54Metaphyseal cupping (HP:0003021)2.49621622
55Hemorrhage of the eye (HP:0011885)2.47536676
56Hyperglycinuria (HP:0003108)2.45768425
57Recurrent abscess formation (HP:0002722)2.43310762
58Abnormality of methionine metabolism (HP:0010901)2.43005392
59Abnormality of transition element cation homeostasis (HP:0011030)2.42648691
60Systemic lupus erythematosus (HP:0002725)2.40210524
61Hypoglycemic coma (HP:0001325)2.39798177
62Abnormality of serine family amino acid metabolism (HP:0010894)2.36821881
63Abnormality of glycine metabolism (HP:0010895)2.36821881
64Increased serum ferritin (HP:0003281)2.36381324
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.34949120
66Gastrointestinal infarctions (HP:0005244)2.33486223
67Abnormality of the nasal mucosa (HP:0000433)2.30412188
68Fat malabsorption (HP:0002630)2.28399362
69Exercise-induced myalgia (HP:0003738)2.26249063
70Ileus (HP:0002595)2.25370252
71Abnormality of nucleobase metabolism (HP:0010932)2.25137344
72Colitis (HP:0002583)2.25073889
73Recurrent gram-negative bacterial infections (HP:0005420)2.23990264
74Recurrent bacterial skin infections (HP:0005406)2.23562444
75Status epilepticus (HP:0002133)2.22750804
76Gingivitis (HP:0000230)2.21796446
77Slow saccadic eye movements (HP:0000514)2.21247101
78Gingival bleeding (HP:0000225)2.20919207
79Abnormal platelet function (HP:0011869)2.19397448
80Impaired platelet aggregation (HP:0003540)2.19397448
81Insomnia (HP:0100785)2.18370215
82Broad face (HP:0000283)2.17413648
83Increased connective tissue (HP:0009025)2.16948490
84Osteomalacia (HP:0002749)2.15239301
85Menorrhagia (HP:0000132)2.14569586
86Abnormality of fatty-acid metabolism (HP:0004359)2.12984555
87Metabolic acidosis (HP:0001942)2.10757539
88Increased mean platelet volume (HP:0011877)2.06545564
89Spontaneous abortion (HP:0005268)2.05373373
90Abnormality of purine metabolism (HP:0004352)2.05341776
91Spontaneous hematomas (HP:0007420)2.03930709
92Cerebral aneurysm (HP:0004944)2.02811138
93Segmental peripheral demyelination/remyelination (HP:0003481)2.02348095
94Esophageal varix (HP:0002040)2.02202085
95Flat acetabular roof (HP:0003180)2.02086268
96Abnormality of the Achilles tendon (HP:0005109)2.01988330
97Gastrointestinal inflammation (HP:0004386)2.01830766
98Abnormality of macrophages (HP:0004311)1.99780965
99Purpura (HP:0000979)1.99673378
100Centrally nucleated skeletal muscle fibers (HP:0003687)1.98878633
101Skin nodule (HP:0200036)1.98470938
102Meningitis (HP:0001287)1.97578914
103Nausea (HP:0002018)1.96286669
104Osteomyelitis (HP:0002754)1.95342905
105Panhypogammaglobulinemia (HP:0003139)1.95127729
106Mitral stenosis (HP:0001718)1.94669567
107Gout (HP:0001997)1.94087291
108Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.93706521
109Chronic obstructive pulmonary disease (HP:0006510)1.93038750
110Obstructive lung disease (HP:0006536)1.93038750
111Spastic diplegia (HP:0001264)1.93034075
112Hypertriglyceridemia (HP:0002155)1.92839477
113Epistaxis (HP:0000421)1.91843735
114Abnormal platelet volume (HP:0011876)1.91532201
115Autoimmune thrombocytopenia (HP:0001973)1.91218778
116Glomerulonephritis (HP:0000099)1.91010642
117Recurrent viral infections (HP:0004429)1.90528236
118Confusion (HP:0001289)1.90324270
119Decreased motor nerve conduction velocity (HP:0003431)1.89422574
120Sensorimotor neuropathy (HP:0007141)1.88897566
121Back pain (HP:0003418)1.86722889
122Inflammation of the large intestine (HP:0002037)1.85561875
123Peripheral hypomyelination (HP:0007182)1.85389574
124Rickets (HP:0002748)1.84612522
125Atelectasis (HP:0100750)1.84606842
126Generalized hyperpigmentation (HP:0007440)1.83818282
127Toxemia of pregnancy (HP:0100603)1.83525809
128Muscle fiber splitting (HP:0003555)1.83304959
129Myopathic facies (HP:0002058)1.82963001
130Recurrent fungal infections (HP:0002841)1.80966369
131Abnormality of the thoracic spine (HP:0100711)1.79943246
132Thrombophlebitis (HP:0004418)1.79841939
133Long palpebral fissure (HP:0000637)1.79268210
134Pathologic fracture (HP:0002756)1.78787898
135Axonal loss (HP:0003447)1.78376431
136Heterotopia (HP:0002282)1.77459132
137Urticaria (HP:0001025)1.76493590
138Abnormal cartilage morphology (HP:0002763)1.76055870
139Abnormality of the fingertips (HP:0001211)1.75388306
140Malnutrition (HP:0004395)1.74632868
141Prolonged bleeding time (HP:0003010)1.74502913
142Bowel incontinence (HP:0002607)1.73089861
143Abnormal delayed hypersensitivity skin test (HP:0002963)1.70512569
144Increased variability in muscle fiber diameter (HP:0003557)1.69687430
145Bilateral sensorineural hearing impairment (HP:0008619)1.69671525
146Myositis (HP:0100614)1.69334679
147Agammaglobulinemia (HP:0004432)1.69074477
148Difficulty running (HP:0009046)1.67870558
149Hypertensive crisis (HP:0100735)1.67131264
150Recurrent otitis media (HP:0000403)1.63954775
151Disproportionate tall stature (HP:0001519)1.63527559
152Long eyelashes (HP:0000527)1.63301552
153Thin bony cortex (HP:0002753)1.62026027
154Seborrheic dermatitis (HP:0001051)1.60017121
155Abnormal large intestine physiology (HP:0012700)1.58546418
156Distal lower limb amyotrophy (HP:0008944)1.58314689
157Polygenic inheritance (HP:0010982)1.58058114
158Germ cell neoplasia (HP:0100728)1.58053952
159Thoracic kyphosis (HP:0002942)1.57768217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.03195819
2CDK123.67345255
3TRIB33.36213405
4MAP3K103.01062223
5ERN12.98141890
6PKN22.74088617
7EIF2AK12.63611613
8SIK12.54567585
9SMG12.49787841
10STK42.38865466
11FGFR42.35601723
12RIPK42.12345966
13EEF2K2.11146663
14TAOK31.94212094
15CAMK1D1.88542224
16STK101.79564326
17TAOK21.78941018
18CDK61.73457119
19BCKDK1.69429336
20MAPK111.64430945
21TYK21.63722009
22MARK21.60036807
23MAP4K11.56421956
24GRK61.51057242
25TTN1.50519491
26RIPK11.46981047
27PTK61.43935965
28TNK21.41697270
29KSR21.40349372
30JAK21.38091220
31MAP3K131.36414357
32TGFBR21.33505883
33MAP3K11.30160351
34CDK41.29885698
35PIM11.28658806
36LATS11.25241502
37NEK21.25101826
38PRKD21.24922439
39BMX1.23125118
40MAP2K31.21167655
41CAMK1G1.21155218
42DYRK1B1.20666020
43BRD41.19910761
44STK31.19053381
45TAOK11.18782250
46PRKAA11.18131508
47ICK1.15074468
48SIK31.14738627
49SGK31.13708235
50JAK11.11363729
51HIPK21.08493642
52MTOR1.07024638
53WNK11.01249990
54TBK10.99941405
55BLK0.99187853
56IRAK40.99118643
57ERBB20.97807788
58MAP3K80.96759391
59MAP3K70.95945676
60CDK90.93634871
61TRPM70.92661391
62FGR0.92262107
63RPS6KC10.91884843
64RPS6KL10.91884843
65MAP3K60.91692519
66PRKAA20.91603675
67IRAK30.89940838
68BTK0.88207682
69IKBKE0.85592818
70TLK10.84672427
71FLT30.84404163
72RPS6KA20.84024308
73PDGFRA0.83927684
74DYRK30.82745850
75MAPK150.81164452
76MAP3K110.80245638
77PTK20.75285494
78ABL20.74535715
79CHUK0.74437313
80FES0.74221194
81MST1R0.73952890
82MAP3K140.71861615
83TYRO30.70798741
84SYK0.69836527
85MAPK120.69775241
86SIK20.69497854
87RPS6KA60.68236344
88ZAP700.67637049
89MAP3K20.67054434
90MAPKAPK30.66736186
91MARK30.65504987
92SGK2230.64389564
93SGK4940.64389564
94IKBKB0.63625879
95DAPK20.63175407
96EPHB10.62401025
97LRRK20.61767562
98YES10.61518016
99MAP2K40.59904330
100SGK20.59357905
101CSK0.56747067
102MELK0.55502508
103JAK30.55357983
104FGFR30.54615688
105HCK0.54401327
106RPS6KA50.54112099
107STK380.53893892
108MAP2K20.52796834
109CAMK40.52432551
110ERBB40.52287297
111MAP3K30.49178646
112CDK70.47691577
113ZAK0.47309629
114PDGFRB0.46573255
115PDPK10.46364976
116PRKD30.46198078
117EGFR0.45094381
118NEK90.44679359
119PTK2B0.44597976
120PIK3CG0.43343410
121NME20.43175430
122PRKACG0.43100510
123CDC70.42690049
124LYN0.41902709
125KSR10.41437359
126ALK0.41416130
127SGK10.41393691
128RET0.40247797
129TIE10.39634139
130MAP3K50.39572093
131RPS6KA40.39352849
132AURKB0.37621414
133RPS6KA10.37052426
134PRKCH0.35188307
135MAPK70.35137996
136PDK10.34671279
137CDC42BPA0.33954642
138PRKCZ0.32229173
139CSF1R0.32037550
140CHEK10.31333215

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.03887189
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.52489962
3Nitrogen metabolism_Homo sapiens_hsa009103.29932158
4Vitamin B6 metabolism_Homo sapiens_hsa007503.01820342
5Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.01003077
6Arginine biosynthesis_Homo sapiens_hsa002202.93643485
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.90960200
8Complement and coagulation cascades_Homo sapiens_hsa046102.80802894
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56028843
10Tryptophan metabolism_Homo sapiens_hsa003802.40046394
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34364706
12Fatty acid degradation_Homo sapiens_hsa000712.28915401
13Notch signaling pathway_Homo sapiens_hsa043302.13822656
14Staphylococcus aureus infection_Homo sapiens_hsa051502.09741650
15ABC transporters_Homo sapiens_hsa020101.99789171
16PPAR signaling pathway_Homo sapiens_hsa033201.96625448
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.88333456
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.78381480
19Systemic lupus erythematosus_Homo sapiens_hsa053221.77219653
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.74935307
21Selenocompound metabolism_Homo sapiens_hsa004501.71995405
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.71533660
23Caffeine metabolism_Homo sapiens_hsa002321.71023854
24Other glycan degradation_Homo sapiens_hsa005111.66761088
25Bile secretion_Homo sapiens_hsa049761.63600924
26Endometrial cancer_Homo sapiens_hsa052131.61403227
27Lysine degradation_Homo sapiens_hsa003101.55731614
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.52614399
29beta-Alanine metabolism_Homo sapiens_hsa004101.52376266
30Butanoate metabolism_Homo sapiens_hsa006501.52207577
31Fatty acid metabolism_Homo sapiens_hsa012121.51572129
32Renal cell carcinoma_Homo sapiens_hsa052111.47757564
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46771132
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.46423759
35VEGF signaling pathway_Homo sapiens_hsa043701.46257916
36Peroxisome_Homo sapiens_hsa041461.46008277
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44085260
38Propanoate metabolism_Homo sapiens_hsa006401.39345989
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.38696298
40Chemical carcinogenesis_Homo sapiens_hsa052041.38183432
41Histidine metabolism_Homo sapiens_hsa003401.37888905
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30955034
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26629159
44Phenylalanine metabolism_Homo sapiens_hsa003601.24881264
45Sulfur relay system_Homo sapiens_hsa041221.24844434
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.24743938
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.21900990
48Choline metabolism in cancer_Homo sapiens_hsa052311.20021599
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19517446
50Prostate cancer_Homo sapiens_hsa052151.17571713
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.15463323
52Biosynthesis of amino acids_Homo sapiens_hsa012301.13463456
53Hepatitis B_Homo sapiens_hsa051611.13315195
54Thyroid cancer_Homo sapiens_hsa052161.11166458
55Leishmaniasis_Homo sapiens_hsa051401.11007780
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09687185
57Retinol metabolism_Homo sapiens_hsa008301.08378989
58Prolactin signaling pathway_Homo sapiens_hsa049171.07988443
59T cell receptor signaling pathway_Homo sapiens_hsa046601.06087473
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05655598
61Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05371482
62Pyruvate metabolism_Homo sapiens_hsa006201.04983484
63ErbB signaling pathway_Homo sapiens_hsa040121.04566727
64Influenza A_Homo sapiens_hsa051641.02728457
65Carbon metabolism_Homo sapiens_hsa012001.01901497
66Fat digestion and absorption_Homo sapiens_hsa049751.01563802
67Inositol phosphate metabolism_Homo sapiens_hsa005621.00116167
68Starch and sucrose metabolism_Homo sapiens_hsa005000.99056678
69Tyrosine metabolism_Homo sapiens_hsa003500.95955334
70Glioma_Homo sapiens_hsa052140.93966140
71Colorectal cancer_Homo sapiens_hsa052100.92668738
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.91973644
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.91116686
74GnRH signaling pathway_Homo sapiens_hsa049120.88028712
75African trypanosomiasis_Homo sapiens_hsa051430.87036179
76Tuberculosis_Homo sapiens_hsa051520.86374632
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.85561203
78One carbon pool by folate_Homo sapiens_hsa006700.85383711
79Folate biosynthesis_Homo sapiens_hsa007900.85263679
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84581944
81Toxoplasmosis_Homo sapiens_hsa051450.84469108
82Insulin resistance_Homo sapiens_hsa049310.83061183
83Chemokine signaling pathway_Homo sapiens_hsa040620.82176011
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81923784
85Herpes simplex infection_Homo sapiens_hsa051680.81658126
86TNF signaling pathway_Homo sapiens_hsa046680.80024300
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.79263935
88HIF-1 signaling pathway_Homo sapiens_hsa040660.78416348
89Glycerolipid metabolism_Homo sapiens_hsa005610.72870442
90HTLV-I infection_Homo sapiens_hsa051660.69920459
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.69201742
92Platelet activation_Homo sapiens_hsa046110.69191527
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68898272
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67801805
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67618531
96Estrogen signaling pathway_Homo sapiens_hsa049150.66385080
97MicroRNAs in cancer_Homo sapiens_hsa052060.66366504
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64039823
99Amoebiasis_Homo sapiens_hsa051460.63897612
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.62082118
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61893369
102Endocytosis_Homo sapiens_hsa041440.61863978
103Pentose phosphate pathway_Homo sapiens_hsa000300.61822543
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61759482
105Vitamin digestion and absorption_Homo sapiens_hsa049770.59684044
106Arginine and proline metabolism_Homo sapiens_hsa003300.58170676
107Steroid biosynthesis_Homo sapiens_hsa001000.56651935
108AMPK signaling pathway_Homo sapiens_hsa041520.56117020
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53226867
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52918831
111Primary immunodeficiency_Homo sapiens_hsa053400.52561110
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52396842
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.51754105
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51386709
115Adherens junction_Homo sapiens_hsa045200.51336779
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48639367
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48585459
118Non-small cell lung cancer_Homo sapiens_hsa052230.48274545
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48066477
120Chronic myeloid leukemia_Homo sapiens_hsa052200.47942479
121Fatty acid biosynthesis_Homo sapiens_hsa000610.46436769
122MAPK signaling pathway_Homo sapiens_hsa040100.45489398
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.44979581
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43840666
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.42933378
126Glutathione metabolism_Homo sapiens_hsa004800.41007409
127Bladder cancer_Homo sapiens_hsa052190.38313842
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38157290
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37814588
130Viral carcinogenesis_Homo sapiens_hsa052030.35573452
131Glucagon signaling pathway_Homo sapiens_hsa049220.32336250
132Insulin signaling pathway_Homo sapiens_hsa049100.32091559
133mTOR signaling pathway_Homo sapiens_hsa041500.31206620
134Malaria_Homo sapiens_hsa051440.30752622
135Dorso-ventral axis formation_Homo sapiens_hsa043200.29414518
136Sulfur metabolism_Homo sapiens_hsa009200.28329026
137Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28282930
138Small cell lung cancer_Homo sapiens_hsa052220.26209350
139Apoptosis_Homo sapiens_hsa042100.25303712
140Alcoholism_Homo sapiens_hsa050340.23707107
141Prion diseases_Homo sapiens_hsa050200.22932260
142Acute myeloid leukemia_Homo sapiens_hsa052210.22902540
143FoxO signaling pathway_Homo sapiens_hsa040680.22257994
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.20111895
145Pancreatic cancer_Homo sapiens_hsa052120.18198476
146Fatty acid elongation_Homo sapiens_hsa000620.17491743
147Osteoclast differentiation_Homo sapiens_hsa043800.16314716
148Hematopoietic cell lineage_Homo sapiens_hsa046400.15614539
149Fructose and mannose metabolism_Homo sapiens_hsa000510.13144392
150Hepatitis C_Homo sapiens_hsa051600.13020650
151Metabolic pathways_Homo sapiens_hsa011000.12911607
152Measles_Homo sapiens_hsa051620.11639224
153NF-kappa B signaling pathway_Homo sapiens_hsa040640.09876482
154B cell receptor signaling pathway_Homo sapiens_hsa046620.09055400
155Type II diabetes mellitus_Homo sapiens_hsa049300.08155474

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