RANBP17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.55216412
2replication fork processing (GO:0031297)6.23975440
3transcription from mitochondrial promoter (GO:0006390)5.49774244
4maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.49162577
5somatic hypermutation of immunoglobulin genes (GO:0016446)5.28780726
6somatic diversification of immune receptors via somatic mutation (GO:0002566)5.28780726
7embryonic process involved in female pregnancy (GO:0060136)5.23350606
8DNA deamination (GO:0045006)5.16334749
9proline metabolic process (GO:0006560)4.75939814
10DNA strand renaturation (GO:0000733)4.69615001
11establishment of apical/basal cell polarity (GO:0035089)4.69028541
12meiotic chromosome segregation (GO:0045132)4.32936076
13mitochondrial DNA metabolic process (GO:0032042)4.21496184
14regulation of gene silencing by RNA (GO:0060966)4.17592747
15regulation of posttranscriptional gene silencing (GO:0060147)4.17592747
16regulation of gene silencing by miRNA (GO:0060964)4.17592747
17telomere maintenance via semi-conservative replication (GO:0032201)4.15650838
18establishment of monopolar cell polarity (GO:0061162)4.11169873
19establishment or maintenance of monopolar cell polarity (GO:0061339)4.11169873
20positive regulation of protein homooligomerization (GO:0032464)4.10728724
21DNA double-strand break processing (GO:0000729)4.04873517
22regulation of integrin activation (GO:0033623)3.97282818
23poly(A)+ mRNA export from nucleus (GO:0016973)3.95367544
24positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.95326407
25positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.95326407
26positive regulation of mitotic sister chromatid separation (GO:1901970)3.95326407
27oxidative demethylation (GO:0070989)3.93899853
28viral mRNA export from host cell nucleus (GO:0046784)3.87962270
29regulation of double-strand break repair via homologous recombination (GO:0010569)3.84973343
30histone H4-K12 acetylation (GO:0043983)3.84966147
31nucleotide-excision repair, DNA gap filling (GO:0006297)3.84513465
32formation of translation preinitiation complex (GO:0001731)3.78986555
33mRNA cleavage (GO:0006379)3.78367916
34regulation of centriole replication (GO:0046599)3.75683455
35kinetochore assembly (GO:0051382)3.73985622
36spliceosomal tri-snRNP complex assembly (GO:0000244)3.73719511
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.71977287
38non-recombinational repair (GO:0000726)3.68547317
39double-strand break repair via nonhomologous end joining (GO:0006303)3.68547317
40base-excision repair (GO:0006284)3.68507143
41mitotic G1 DNA damage checkpoint (GO:0031571)3.68478352
42DNA strand elongation involved in DNA replication (GO:0006271)3.66664899
43regulation of sister chromatid cohesion (GO:0007063)3.63971515
44regulation of double-strand break repair (GO:2000779)3.62181280
45telomere maintenance via recombination (GO:0000722)3.61149090
46DNA integration (GO:0015074)3.57344294
47mitotic sister chromatid segregation (GO:0000070)3.53534366
48kinetochore organization (GO:0051383)3.53255819
49regulation of RNA export from nucleus (GO:0046831)3.52948626
50centriole replication (GO:0007099)3.52724657
51maturation of 5.8S rRNA (GO:0000460)3.51359573
52regulation of translational fidelity (GO:0006450)3.50701147
53resolution of meiotic recombination intermediates (GO:0000712)3.49164014
54epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.47845954
55DNA strand elongation (GO:0022616)3.47154010
56negative regulation of DNA-dependent DNA replication (GO:2000104)3.40945141
57chromatin remodeling at centromere (GO:0031055)3.40812140
58termination of RNA polymerase II transcription (GO:0006369)3.37625989
59single strand break repair (GO:0000012)3.37067973
60regulation of protein homooligomerization (GO:0032462)3.36491463
61DNA ligation (GO:0006266)3.35370966
62dosage compensation (GO:0007549)3.35169038
63determination of adult lifespan (GO:0008340)3.33562149
64positive regulation of chromosome segregation (GO:0051984)3.32861236
65regulation of DNA damage checkpoint (GO:2000001)3.32146947
66piRNA metabolic process (GO:0034587)3.32018347
67neural tube formation (GO:0001841)3.27504230
68pre-miRNA processing (GO:0031054)3.25759194
69G1 DNA damage checkpoint (GO:0044783)3.25141889
70mitotic recombination (GO:0006312)3.24576513
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.22659260
72recombinational repair (GO:0000725)3.20719232
73double-strand break repair via homologous recombination (GO:0000724)3.20049665
74synapsis (GO:0007129)3.19597646
75regulation of spindle checkpoint (GO:0090231)3.18679920
76negative regulation of JAK-STAT cascade (GO:0046426)3.18155013
77histone exchange (GO:0043486)3.17187320
78telomere maintenance via telomere lengthening (GO:0010833)3.15998302
79regulation of mitotic spindle checkpoint (GO:1903504)3.15938226
80regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.15938226
81nuclear pore organization (GO:0006999)3.15851192
82mitotic G1/S transition checkpoint (GO:0044819)3.15533449
83CENP-A containing nucleosome assembly (GO:0034080)3.12311102
84DNA replication initiation (GO:0006270)3.11588779
85DNA replication-dependent nucleosome assembly (GO:0006335)3.09860550
86DNA replication-dependent nucleosome organization (GO:0034723)3.09860550
87axonemal dynein complex assembly (GO:0070286)3.08334121
88base-excision repair, AP site formation (GO:0006285)3.07384451
89regulation of helicase activity (GO:0051095)3.07328259
90microtubule depolymerization (GO:0007019)3.07163998
91embryonic placenta development (GO:0001892)3.07004770
92detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.06316947
93mismatch repair (GO:0006298)3.06143856
94regulation of cilium movement (GO:0003352)3.04741682
95mitotic nuclear envelope disassembly (GO:0007077)3.04584598
96mitochondrial RNA metabolic process (GO:0000959)3.03145036
97protein K11-linked deubiquitination (GO:0035871)3.02551405
98epithelial cilium movement (GO:0003351)3.02016987
99negative regulation of cell cycle arrest (GO:0071157)3.01888834
100postreplication repair (GO:0006301)3.00765124
101protein K6-linked ubiquitination (GO:0085020)3.00728805
102sister chromatid segregation (GO:0000819)3.00032556
103nuclear pore complex assembly (GO:0051292)2.98671466
104trophectodermal cell differentiation (GO:0001829)2.98353216
105negative regulation of mRNA processing (GO:0050686)2.97819137
106DNA topological change (GO:0006265)2.97151152
107regulation of histone H3-K9 methylation (GO:0051570)2.96860095
108mRNA export from nucleus (GO:0006406)2.96656293
109embryonic camera-type eye development (GO:0031076)2.95951061
110histone H2A acetylation (GO:0043968)2.92957859
111negative regulation of translation, ncRNA-mediated (GO:0040033)2.92225404
112regulation of translation, ncRNA-mediated (GO:0045974)2.92225404
113negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.92225404
114negative regulation of chromosome segregation (GO:0051985)2.92002709
115regulation of meiosis I (GO:0060631)2.90741837
116regulation of centrosome cycle (GO:0046605)2.89843963
117intraciliary transport (GO:0042073)2.89190610
118microtubule polymerization or depolymerization (GO:0031109)2.85725468
119regulation of cell cycle checkpoint (GO:1901976)2.85519897
120cellular response to ATP (GO:0071318)2.83081794
121ribosome biogenesis (GO:0042254)2.82995053
122regulation of protein polyubiquitination (GO:1902914)2.82818337
123response to pheromone (GO:0019236)2.81597921
124regulation of centrosome duplication (GO:0010824)2.79946451
125limb bud formation (GO:0060174)2.77601903
126DNA catabolic process, exonucleolytic (GO:0000738)2.75660753
127cullin deneddylation (GO:0010388)2.75344601
128regulation of nuclear cell cycle DNA replication (GO:0033262)2.75136616
129regulation of DNA endoreduplication (GO:0032875)2.74666788
130cilium morphogenesis (GO:0060271)2.74434688
131attachment of spindle microtubules to kinetochore (GO:0008608)2.74410116
132negative regulation of DNA recombination (GO:0045910)2.73941676
133metaphase plate congression (GO:0051310)2.73120166
134microtubule anchoring (GO:0034453)2.71848298
135protein polyglutamylation (GO:0018095)2.71520256
136spindle checkpoint (GO:0031577)2.71492100
137photoreceptor cell maintenance (GO:0045494)2.69447943
138regulation of hippo signaling (GO:0035330)2.69011138
139response to X-ray (GO:0010165)2.65713740
140translesion synthesis (GO:0019985)2.64394461
141DNA replication checkpoint (GO:0000076)2.63525865
142presynaptic membrane assembly (GO:0097105)2.60547227
143reciprocal DNA recombination (GO:0035825)2.59225706
144reciprocal meiotic recombination (GO:0007131)2.59225706
145cilium organization (GO:0044782)2.58750368
146centrosome organization (GO:0051297)2.56716484
147microtubule organizing center organization (GO:0031023)2.55399576
148cilium assembly (GO:0042384)2.55393865
149protein localization to kinetochore (GO:0034501)2.54761865
150mitotic spindle checkpoint (GO:0071174)2.54192167
151RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.54055202
152double-strand break repair (GO:0006302)2.51339995
153platelet dense granule organization (GO:0060155)2.49902470
154fucose catabolic process (GO:0019317)2.47592432
155L-fucose metabolic process (GO:0042354)2.47592432
156L-fucose catabolic process (GO:0042355)2.47592432
157protein prenylation (GO:0018342)2.46893950
158prenylation (GO:0097354)2.46893950
159male meiosis (GO:0007140)2.46709432
160histone mRNA metabolic process (GO:0008334)2.46115743
161histone mRNA catabolic process (GO:0071044)2.45607169
162behavioral response to nicotine (GO:0035095)2.45516905
163retinal cone cell development (GO:0046549)2.44637582
164nonmotile primary cilium assembly (GO:0035058)2.43793103
165negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.42669378
166negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.42669378
167negative regulation of mitotic sister chromatid segregation (GO:0033048)2.42669378
168negative regulation of mitotic sister chromatid separation (GO:2000816)2.42669378
169negative regulation of sister chromatid segregation (GO:0033046)2.42669378
170respiratory chain complex IV assembly (GO:0008535)2.40721850
171cilium movement (GO:0003341)2.40147251
172DNA replication-independent nucleosome assembly (GO:0006336)2.38729069
173DNA replication-independent nucleosome organization (GO:0034724)2.38729069
174regulation of mitotic metaphase/anaphase transition (GO:0030071)2.38377293
175regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.38377293
176mitotic metaphase plate congression (GO:0007080)2.38317652
177cilium or flagellum-dependent cell motility (GO:0001539)2.38276039
178sperm motility (GO:0030317)2.37963770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.63132475
2SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.61178299
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.59524099
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.59524099
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.59524099
6* MYC_18555785_ChIP-Seq_MESCs_Mouse3.38601833
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.24903039
8ZNF274_21170338_ChIP-Seq_K562_Hela3.00979823
9GBX2_23144817_ChIP-Seq_PC3_Human2.97531529
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.94751858
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.74306241
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71901784
13FUS_26573619_Chip-Seq_HEK293_Human2.71484294
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.68971452
15NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.68543236
16* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.66776697
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.65765456
18* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.59535930
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.54168875
20VDR_22108803_ChIP-Seq_LS180_Human2.51620607
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50086666
22IGF1R_20145208_ChIP-Seq_DFB_Human2.48554465
23* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47754510
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.44561291
25TAF15_26573619_Chip-Seq_HEK293_Human2.43384157
26EWS_26573619_Chip-Seq_HEK293_Human2.40015745
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39689577
28MYC_18358816_ChIP-ChIP_MESCs_Mouse2.38590437
29SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.34264227
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.29051576
31NANOG_18555785_ChIP-Seq_MESCs_Mouse2.25058353
32P300_19829295_ChIP-Seq_ESCs_Human2.24684165
33TCF3_18692474_ChIP-Seq_MESCs_Mouse2.24132756
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21469480
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20923109
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.16354095
37CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14922634
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.96480509
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.95305098
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94515147
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93783068
42* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93419338
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92961123
44* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.92915796
45* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.90499199
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.90038226
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.87204712
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.85656443
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84509216
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83813401
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.82702365
52TCF3_18692474_ChIP-Seq_MEFs_Mouse1.82692532
53* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.82556914
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.81977725
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80273328
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.79556664
57NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.76170826
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75851290
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.72735517
60* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72415992
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71543038
62ELK1_19687146_ChIP-ChIP_HELA_Human1.70296450
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70184528
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.69720558
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67392324
66* NANOG_21062744_ChIP-ChIP_HESCs_Human1.65985350
67* SMAD4_21799915_ChIP-Seq_A2780_Human1.65668473
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65003051
69ER_23166858_ChIP-Seq_MCF-7_Human1.62611623
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.62305492
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60408809
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59951778
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59823424
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.58739063
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58069870
76* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58049940
77NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.57439607
78HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54760376
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52230037
80STAT3_23295773_ChIP-Seq_U87_Human1.51078338
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.49699099
82* E2F1_21310950_ChIP-Seq_MCF-7_Human1.49289701
83CBP_20019798_ChIP-Seq_JUKART_Human1.48825142
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48825142
85* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47073866
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46424140
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.45616166
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45306112
89* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43540376
90* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43065057
91POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.42943627
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42021630
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40817983
94SOX2_18692474_ChIP-Seq_MESCs_Mouse1.40591200
95BCAT_22108803_ChIP-Seq_LS180_Human1.39646650
96NANOG_18692474_ChIP-Seq_MESCs_Mouse1.39524219
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39268872
98EZH2_22144423_ChIP-Seq_EOC_Human1.39086668
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38695266
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38152712
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38152712
102GABP_19822575_ChIP-Seq_HepG2_Human1.37837377
103AR_25329375_ChIP-Seq_VCAP_Human1.36981749
104EZH2_27294783_Chip-Seq_NPCs_Mouse1.36478345
105TP63_19390658_ChIP-ChIP_HaCaT_Human1.36190700
106* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35352789
107DCP1A_22483619_ChIP-Seq_HELA_Human1.34452479
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34074250
109* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33687248
110MYC_18940864_ChIP-ChIP_HL60_Human1.33536407
111EST1_17652178_ChIP-ChIP_JURKAT_Human1.32870628
112TTF2_22483619_ChIP-Seq_HELA_Human1.32125451
113TCF4_23295773_ChIP-Seq_U87_Human1.31897029
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30726387
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30386169
116XRN2_22483619_ChIP-Seq_HELA_Human1.29732626
117SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26291597
118KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25627822
119PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23745039
120TCF4_22108803_ChIP-Seq_LS180_Human1.22319074
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21907644
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21891387
123TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21587628
124KDM5A_27292631_Chip-Seq_BREAST_Human1.21534211
125* RUNX2_22187159_ChIP-Seq_PCA_Human1.21100836
126PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19753202
127PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.19734760
128NFE2_27457419_Chip-Seq_LIVER_Mouse1.19648631
129KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19458746
130VDR_23849224_ChIP-Seq_CD4+_Human1.18961900
131HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18583631
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18430258
133TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.18087928
134NANOG_18555785_Chip-Seq_ESCs_Mouse1.17421965
135SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16952932
136* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15433475
137KAP1_27257070_Chip-Seq_ESCs_Mouse1.15432388
138* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14185877
139BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11934495
140PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11303193
141GABP_17652178_ChIP-ChIP_JURKAT_Human1.11176168
142SOX2_19829295_ChIP-Seq_ESCs_Human1.11150705
143NANOG_19829295_ChIP-Seq_ESCs_Human1.11150705
144RNF2_27304074_Chip-Seq_NSC_Mouse1.10851827
145ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09970192
146YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09277800
147SMAD4_21741376_ChIP-Seq_EPCs_Human1.09170363
148KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08258794
149BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07801716
150FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07305038
151CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06907260
152* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06902182
153* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06770192
154NANOG_18692474_ChIP-Seq_MEFs_Mouse1.06733712
155TP53_22573176_ChIP-Seq_HFKS_Human1.06123238
156CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06025971
157EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05601080
158POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.05372920
159* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05336061
160GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03906309
161IRF1_19129219_ChIP-ChIP_H3396_Human1.02818465
162* NANOG_16518401_ChIP-PET_MESCs_Mouse1.02120033
163SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00897594
164CRX_20693478_ChIP-Seq_RETINA_Mouse1.00862131
165CBX2_27304074_Chip-Seq_ESCs_Mouse0.99758106
166CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99417648
167* FLI1_21867929_ChIP-Seq_TH2_Mouse0.99228581
168E2F1_18555785_Chip-Seq_ESCs_Mouse0.99184912
169P53_22387025_ChIP-Seq_ESCs_Mouse0.97754077
170CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97706898
171VDR_21846776_ChIP-Seq_THP-1_Human0.97625233
172CDX2_22108803_ChIP-Seq_LS180_Human0.96907087
173SOX9_26525672_Chip-Seq_HEART_Mouse0.95273383
174CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95081161
175FOXP3_21729870_ChIP-Seq_TREG_Human0.94814787
176* JUN_21703547_ChIP-Seq_K562_Human0.94125186
177OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93616504
178FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93043346
179SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92070734
180ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92065080
181* TAL1_26923725_Chip-Seq_HPCs_Mouse0.91971619
182TET1_21451524_ChIP-Seq_MESCs_Mouse0.90690507
183EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89534723
184TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.89105893
185RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87604440
186RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87359544
187PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85851820

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.13737370
2MP0010094_abnormal_chromosome_stability3.76206142
3MP0008877_abnormal_DNA_methylation3.34035423
4MP0008058_abnormal_DNA_repair3.10383281
5MP0003111_abnormal_nucleus_morphology3.04418155
6MP0010030_abnormal_orbit_morphology2.94726406
7MP0003693_abnormal_embryo_hatching2.93045160
8MP0000569_abnormal_digit_pigmentation2.89582343
9MP0005171_absent_coat_pigmentation2.83224687
10MP0004957_abnormal_blastocyst_morpholog2.81608024
11MP0009278_abnormal_bone_marrow2.66215538
12MP0003890_abnormal_embryonic-extraembry2.64273138
13MP0002009_preneoplasia2.62192669
14MP0003786_premature_aging2.60766298
15MP0002102_abnormal_ear_morphology2.58240914
16MP0003077_abnormal_cell_cycle2.47560551
17MP0002653_abnormal_ependyma_morphology2.45673795
18MP0002938_white_spotting2.41853041
19MP0008995_early_reproductive_senescence2.35969654
20MP0004133_heterotaxia2.30627275
21MP0004233_abnormal_muscle_weight2.23867949
22MP0008932_abnormal_embryonic_tissue2.04173706
23MP0006072_abnormal_retinal_apoptosis1.99588230
24MP0000372_irregular_coat_pigmentation1.99503733
25MP0003283_abnormal_digestive_organ1.94572496
26MP0005410_abnormal_fertilization1.87817990
27MP0005551_abnormal_eye_electrophysiolog1.87704513
28MP0003119_abnormal_digestive_system1.86808296
29MP0001293_anophthalmia1.85567696
30MP0002084_abnormal_developmental_patter1.81040535
31MP0001929_abnormal_gametogenesis1.77852969
32MP0002210_abnormal_sex_determination1.76280656
33MP0002234_abnormal_pharynx_morphology1.71937122
34MP0009697_abnormal_copulation1.69343779
35MP0002085_abnormal_embryonic_tissue1.67288698
36MP0010352_gastrointestinal_tract_polyps1.67036307
37MP0003880_abnormal_central_pattern1.66025085
38MP0002736_abnormal_nociception_after1.64210376
39MP0001145_abnormal_male_reproductive1.63940232
40MP0001697_abnormal_embryo_size1.59225575
41MP0001529_abnormal_vocalization1.55808314
42MP0000350_abnormal_cell_proliferation1.55047686
43MP0002086_abnormal_extraembryonic_tissu1.54635170
44MP0003698_abnormal_male_reproductive1.53144306
45MP0002249_abnormal_larynx_morphology1.51231583
46MP0005380_embryogenesis_phenotype1.50741281
47MP0001672_abnormal_embryogenesis/_devel1.50741281
48MP0001730_embryonic_growth_arrest1.48792831
49MP0000427_abnormal_hair_cycle1.46643295
50MP0004197_abnormal_fetal_growth/weight/1.46390385
51MP0005076_abnormal_cell_differentiation1.45458235
52MP0006292_abnormal_olfactory_placode1.45269928
53MP0008007_abnormal_cellular_replicative1.44365076
54MP0003136_yellow_coat_color1.41282265
55MP0003718_maternal_effect1.40648443
56MP0001545_abnormal_hematopoietic_system1.39445434
57MP0005397_hematopoietic_system_phenotyp1.39445434
58MP0000653_abnormal_sex_gland1.36821420
59MP0005075_abnormal_melanosome_morpholog1.36632935
60MP0001984_abnormal_olfaction1.35592522
61MP0003941_abnormal_skin_development1.35385784
62MP0002233_abnormal_nose_morphology1.32307651
63MP0010307_abnormal_tumor_latency1.32237164
64MP0005174_abnormal_tail_pigmentation1.31964249
65MP0000490_abnormal_crypts_of1.31520913
66MP0003567_abnormal_fetal_cardiomyocyte1.30944468
67MP0008789_abnormal_olfactory_epithelium1.30299213
68MP0004147_increased_porphyrin_level1.28019699
69MP0000631_abnormal_neuroendocrine_gland1.27994693
70MP0006276_abnormal_autonomic_nervous1.27421784
71MP0001486_abnormal_startle_reflex1.27333285
72MP0001485_abnormal_pinna_reflex1.24975491
73MP0002638_abnormal_pupillary_reflex1.24771228
74MP0003787_abnormal_imprinting1.24123267
75MP0001968_abnormal_touch/_nociception1.17563812
76MP0000371_diluted_coat_color1.15697094
77MP0000383_abnormal_hair_follicle1.15498838
78MP0003984_embryonic_growth_retardation1.15331543
79MP0002282_abnormal_trachea_morphology1.14994682
80MP0002080_prenatal_lethality1.14199473
81MP0004215_abnormal_myocardial_fiber1.14021360
82MP0000015_abnormal_ear_pigmentation1.12652908
83MP0003195_calcinosis1.10955674
84MP0002088_abnormal_embryonic_growth/wei1.10769790
85MP0005084_abnormal_gallbladder_morpholo1.09895430
86MP0000778_abnormal_nervous_system1.08234628
87MP0002161_abnormal_fertility/fecundity1.07317286
88MP0003011_delayed_dark_adaptation1.06806779
89MP0003122_maternal_imprinting1.06413372
90MP0002254_reproductive_system_inflammat1.03981026
91MP0000647_abnormal_sebaceous_gland1.03799638
92MP0000462_abnormal_digestive_system1.01363896
93MP0005248_abnormal_Harderian_gland1.00939191
94MP0002111_abnormal_tail_morphology1.00828582
95MP0009046_muscle_twitch0.98453128
96MP0003878_abnormal_ear_physiology0.97693578
97MP0005377_hearing/vestibular/ear_phenot0.97693578
98MP0000313_abnormal_cell_death0.97084911
99MP0004264_abnormal_extraembryonic_tissu0.95991726
100MP0002075_abnormal_coat/hair_pigmentati0.95641457
101MP0002019_abnormal_tumor_incidence0.95222924
102MP0003646_muscle_fatigue0.94671634
103MP0002095_abnormal_skin_pigmentation0.93643095
104MP0000579_abnormal_nail_morphology0.93411834
105MP0000470_abnormal_stomach_morphology0.92928317
106MP0005187_abnormal_penis_morphology0.92767636
107MP0005646_abnormal_pituitary_gland0.92299461
108MP0001324_abnormal_eye_pigmentation0.91413207
109MP0005195_abnormal_posterior_eye0.91003342
110MP0005394_taste/olfaction_phenotype0.90789226
111MP0005499_abnormal_olfactory_system0.90789226
112MP0003755_abnormal_palate_morphology0.89645551
113MP0010386_abnormal_urinary_bladder0.88186849
114MP0001299_abnormal_eye_distance/0.87786937
115MP0000432_abnormal_head_morphology0.87412765
116MP0005395_other_phenotype0.87384056
117MP0003453_abnormal_keratinocyte_physiol0.87005808
118MP0001177_atelectasis0.86608946
119MP0002114_abnormal_axial_skeleton0.85981479
120MP0002090_abnormal_vision0.85201241
121MP0002752_abnormal_somatic_nervous0.85110255
122MP0003943_abnormal_hepatobiliary_system0.85083991
123MP0002557_abnormal_social/conspecific_i0.84913539
124MP0004043_abnormal_pH_regulation0.84342457
125MP0002184_abnormal_innervation0.83910267
126MP0001186_pigmentation_phenotype0.82934055
127MP0001119_abnormal_female_reproductive0.82915689
128MP0003935_abnormal_craniofacial_develop0.82122125
129MP0008872_abnormal_physiological_respon0.81981529
130MP0000516_abnormal_urinary_system0.81409211
131MP0005367_renal/urinary_system_phenotyp0.81409211
132MP0003123_paternal_imprinting0.79282578
133MP0003861_abnormal_nervous_system0.77712204
134MP0003936_abnormal_reproductive_system0.77322569
135MP0005253_abnormal_eye_physiology0.75690551
136MP0002269_muscular_atrophy0.75542939
137MP0002116_abnormal_craniofacial_bone0.75479638
138MP0005391_vision/eye_phenotype0.75297339
139MP0002932_abnormal_joint_morphology0.74193090
140MP0003699_abnormal_female_reproductive0.72837146
141MP0000762_abnormal_tongue_morphology0.71968462
142MP0003121_genomic_imprinting0.70869433
143MP0002697_abnormal_eye_size0.70356696
144MP0005266_abnormal_metabolism0.66776965
145MP0005645_abnormal_hypothalamus_physiol0.66403191
146MP0002751_abnormal_autonomic_nervous0.65891061
147MP0005389_reproductive_system_phenotype0.64598220
148MP0001340_abnormal_eyelid_morphology0.64213027
149MP0000049_abnormal_middle_ear0.63330938
150MP0001286_abnormal_eye_development0.63278158
151MP0003937_abnormal_limbs/digits/tail_de0.62899779
152MP0005501_abnormal_skin_physiology0.62693778
153MP0009703_decreased_birth_body0.60776795
154MP0002160_abnormal_reproductive_system0.60250301

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.46483901
2Rectal fistula (HP:0100590)4.39192833
3Rectovaginal fistula (HP:0000143)4.39192833
4Facial hemangioma (HP:0000329)4.11010114
5Intestinal fistula (HP:0100819)3.99741789
6Absent radius (HP:0003974)3.90272229
7Pancreatic cysts (HP:0001737)3.79079134
8Concave nail (HP:0001598)3.75537688
9Short humerus (HP:0005792)3.69522436
10Aplasia involving forearm bones (HP:0009822)3.67559846
11Absent forearm bone (HP:0003953)3.67559846
12Aplasia/hypoplasia of the humerus (HP:0006507)3.65149098
13Vaginal fistula (HP:0004320)3.62776125
14Absent thumb (HP:0009777)3.59929834
15Abnormality of the labia minora (HP:0012880)3.56184325
16Pancreatic fibrosis (HP:0100732)3.55015596
17Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.52584365
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.52511267
19Abnormal respiratory epithelium morphology (HP:0012253)3.40599092
20Abnormal respiratory motile cilium morphology (HP:0005938)3.40599092
21Selective tooth agenesis (HP:0001592)3.37693651
22True hermaphroditism (HP:0010459)3.32520101
23Intestinal atresia (HP:0011100)3.27457742
24Chromsome breakage (HP:0040012)3.27213604
25Molar tooth sign on MRI (HP:0002419)3.22427386
26Abnormality of midbrain morphology (HP:0002418)3.22427386
27Abnormality of the ileum (HP:0001549)3.13574698
28Patellar aplasia (HP:0006443)3.13425913
29Hypochromic microcytic anemia (HP:0004840)3.12442489
30Poikiloderma (HP:0001029)3.08414322
31Colon cancer (HP:0003003)3.05393277
32Increased IgM level (HP:0003496)2.97352948
33Annular pancreas (HP:0001734)2.96894996
34Nephronophthisis (HP:0000090)2.96421711
35Male infertility (HP:0003251)2.96348510
36Volvulus (HP:0002580)2.95927911
37Ependymoma (HP:0002888)2.95841202
38Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.93908808
39Chronic hepatic failure (HP:0100626)2.91959053
40Neoplasm of the oral cavity (HP:0100649)2.91666609
41Tongue fasciculations (HP:0001308)2.90741252
42Abnormality of the astrocytes (HP:0100707)2.90090289
43Astrocytoma (HP:0009592)2.90090289
44Aplasia/Hypoplasia of the patella (HP:0006498)2.87450921
45Supernumerary spleens (HP:0009799)2.74053008
46Abnormality of the renal medulla (HP:0100957)2.71650917
47Basal cell carcinoma (HP:0002671)2.68468709
48Medial flaring of the eyebrow (HP:0010747)2.67929314
49Impulsivity (HP:0100710)2.66937223
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.66717374
51Squamous cell carcinoma (HP:0002860)2.62970002
52Absent/shortened dynein arms (HP:0200106)2.61150661
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.61150661
54Abnormality of the renal cortex (HP:0011035)2.60042353
55Broad alveolar ridges (HP:0000187)2.59563802
56Hyperventilation (HP:0002883)2.56442615
57Muscle fibrillation (HP:0010546)2.56072864
58Glioma (HP:0009733)2.55001404
59Pustule (HP:0200039)2.54560605
60Orthostatic hypotension (HP:0001278)2.54204871
61Breast hypoplasia (HP:0003187)2.53486100
62Median cleft lip (HP:0000161)2.51571392
63Aplasia/Hypoplasia of the tibia (HP:0005772)2.50170704
64Medulloblastoma (HP:0002885)2.47408000
65Bifid tongue (HP:0010297)2.46685086
66Abnormal biliary tract physiology (HP:0012439)2.45686964
67Bile duct proliferation (HP:0001408)2.45686964
68Premature graying of hair (HP:0002216)2.44609746
69Alopecia of scalp (HP:0002293)2.44397079
70Sloping forehead (HP:0000340)2.41912786
71Short thumb (HP:0009778)2.41529638
72Meckel diverticulum (HP:0002245)2.41391060
73Gastrointestinal atresia (HP:0002589)2.41350643
74Hypoplasia of the radius (HP:0002984)2.41225410
75Alacrima (HP:0000522)2.40020402
76Aplasia/Hypoplasia of the tongue (HP:0010295)2.38058062
77Cystic liver disease (HP:0006706)2.35702952
78Genital tract atresia (HP:0001827)2.35691007
79Abnormality of the preputium (HP:0100587)2.33675795
80Duodenal stenosis (HP:0100867)2.33420785
81Small intestinal stenosis (HP:0012848)2.33420785
82Coronal craniosynostosis (HP:0004440)2.30411902
83Abnormality of chromosome stability (HP:0003220)2.30221193
84Turricephaly (HP:0000262)2.28314166
85Birth length less than 3rd percentile (HP:0003561)2.28168061
86Vaginal atresia (HP:0000148)2.26954688
87Abnormal number of incisors (HP:0011064)2.26642974
88Abnormality of male internal genitalia (HP:0000022)2.25168880
89Abnormality of the duodenum (HP:0002246)2.24510536
90Abnormality of abdominal situs (HP:0011620)2.22350965
91Abdominal situs inversus (HP:0003363)2.22350965
92Nephroblastoma (Wilms tumor) (HP:0002667)2.22196776
93Ulnar bowing (HP:0003031)2.22077935
94Congenital primary aphakia (HP:0007707)2.21900885
95Tubulointerstitial nephritis (HP:0001970)2.21780601
96Shawl scrotum (HP:0000049)2.21525073
97Postaxial foot polydactyly (HP:0001830)2.20350312
98Abnormality of the lower motor neuron (HP:0002366)2.20188065
99Preaxial hand polydactyly (HP:0001177)2.19056565
100Anteriorly placed anus (HP:0001545)2.18224991
101Gait imbalance (HP:0002141)2.17417914
102Infertility (HP:0000789)2.16713047
103Capillary hemangiomas (HP:0005306)2.16476189
104Abnormal lung lobation (HP:0002101)2.15638475
105Oligodactyly (hands) (HP:0001180)2.15223559
106Hypotelorism (HP:0000601)2.10769282
107Short chin (HP:0000331)2.10408071
108Anencephaly (HP:0002323)2.09998787
109Nephrogenic diabetes insipidus (HP:0009806)2.08742933
110Astigmatism (HP:0000483)2.05745364
111Attenuation of retinal blood vessels (HP:0007843)2.04338580
112Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.03906468
113Vertebral hypoplasia (HP:0008417)2.03906468
114Sclerocornea (HP:0000647)2.03344047
115Acute lymphatic leukemia (HP:0006721)2.02824527
116Embryonal renal neoplasm (HP:0011794)2.02781645
117Abnormal hemoglobin (HP:0011902)2.01734631
118Decreased lacrimation (HP:0000633)2.00938357
119Albinism (HP:0001022)2.00378158
120Tubular atrophy (HP:0000092)1.99793537
121Dandy-Walker malformation (HP:0001305)1.99474154
122Short tibia (HP:0005736)1.99256583
123Dysautonomia (HP:0002459)1.98733585
124Duplicated collecting system (HP:0000081)1.98268999
125Clubbing of toes (HP:0100760)1.97888677
126Drooling (HP:0002307)1.95812986
127Spinal muscular atrophy (HP:0007269)1.95562759
128Rhabdomyosarcoma (HP:0002859)1.93987971
129Abnormal respiratory motile cilium physiology (HP:0012261)1.93967953
130Postaxial hand polydactyly (HP:0001162)1.93453153
131Triphalangeal thumb (HP:0001199)1.93291097
132Ectopic kidney (HP:0000086)1.93144649
133Abnormality of the aortic arch (HP:0012303)1.93002330
134Vertebral fusion (HP:0002948)1.92208108
135Optic nerve hypoplasia (HP:0000609)1.92004613
136Hamartoma (HP:0010566)1.90998383
137Abolished electroretinogram (ERG) (HP:0000550)1.90558407
138Abnormality of the carotid arteries (HP:0005344)1.90064828
139Congenital hepatic fibrosis (HP:0002612)1.89927270
140Degeneration of anterior horn cells (HP:0002398)1.89754664
141Abnormality of the anterior horn cell (HP:0006802)1.89754664
142Hyperglycinemia (HP:0002154)1.88914567
143Gaze-evoked nystagmus (HP:0000640)1.86809451
144Small hand (HP:0200055)1.86237279
145Bifid uvula (HP:0000193)1.85857600
146Congenital hip dislocation (HP:0001374)1.85315750
147Congenital stationary night blindness (HP:0007642)1.84100962
148Myelodysplasia (HP:0002863)1.83707780
149Lissencephaly (HP:0001339)1.83087732
150Renal hypoplasia (HP:0000089)1.81948733
151Narrow forehead (HP:0000341)1.81502111
152Occipital encephalocele (HP:0002085)1.81432871
153Type II lissencephaly (HP:0007260)1.80703606
154Hypoplasia of the ulna (HP:0003022)1.80555377
155Increased number of teeth (HP:0011069)1.80062864
156Cerebellar dysplasia (HP:0007033)1.79064579
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78379545
158Anophthalmia (HP:0000528)1.76276459
159Oculomotor apraxia (HP:0000657)1.75311090
160Poor coordination (HP:0002370)1.74557380
161Hyperglycinuria (HP:0003108)1.74548961
162Renal cortical cysts (HP:0000803)1.73471799
163Oligohydramnios (HP:0001562)1.71914944
164Cupped ear (HP:0000378)1.70799761
165Pendular nystagmus (HP:0012043)1.70100912
166Hypoplastic labia majora (HP:0000059)1.69149402
167Fair hair (HP:0002286)1.68103374
168Aganglionic megacolon (HP:0002251)1.67639666
169Neoplasm of the adrenal cortex (HP:0100641)1.66937005
170Excessive salivation (HP:0003781)1.66527666
171Increased corneal curvature (HP:0100692)1.66418289
172Keratoconus (HP:0000563)1.66418289
173Abnormality of glycine metabolism (HP:0010895)1.65896968
174Abnormality of serine family amino acid metabolism (HP:0010894)1.65896968
175Cutaneous finger syndactyly (HP:0010554)1.65369522
176Aplasia/Hypoplasia of the sternum (HP:0006714)1.65153979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.36511466
2FRK3.99016212
3MAP3K63.98483765
4MAPK153.94246743
5DDR23.78848840
6PINK12.84563682
7BMPR1B2.70229831
8AKT32.46728183
9NUAK12.35696574
10TYRO32.35261142
11MATK2.32983118
12CDC72.31759436
13MAP3K112.31281738
14CASK2.28246730
15INSRR2.26351017
16CDK72.26006424
17TRIM282.18193736
18WEE12.16507296
19MAP4K22.16313151
20YES12.15884105
21FGR2.15328851
22CDK122.05247318
23DAPK11.97481679
24TNIK1.95341132
25CHEK21.95105702
26STK391.87591444
27NEK21.76362241
28PLK11.73633751
29UHMK11.71605196
30BUB11.69063614
31PRKD21.65531446
32PDK31.60418369
33PDK41.60418369
34DYRK1B1.58340707
35TTK1.55403897
36DYRK31.55276109
37BCR1.54005580
38EPHA21.53827076
39MAP3K41.49294006
40LATS21.46160752
41ATR1.45930846
42BMX1.45868417
43PLK21.42677995
44CSK1.41814220
45PIM11.37760370
46MAPK131.35643102
47GRK11.34757979
48PIM21.31368090
49OXSR11.30382133
50ADRBK21.29880171
51PBK1.24326600
52CDK61.23312305
53CCNB11.18370427
54PDGFRA1.17688373
55EPHA41.15341344
56TSSK61.12790516
57SRPK11.08232882
58CSNK1G11.06821557
59RPS6KB21.03645392
60PDK21.03494897
61TGFBR11.01995606
62CHEK11.00729292
63STK38L1.00697558
64MST40.99693607
65TLK10.98620197
66PAK30.96534284
67TRPM70.94186311
68NEK10.94049205
69TIE10.91969169
70ATM0.91360020
71RPS6KL10.89866252
72RPS6KC10.89866252
73WNK40.89212894
74CDC42BPA0.88896395
75PLK40.88650817
76AURKB0.87337044
77AURKA0.87062328
78CDK20.86728425
79CSNK1G20.86341936
80STK30.84183006
81FER0.82462228
82FGFR20.82086396
83MKNK20.81415172
84MAP2K70.81382135
85ACVR1B0.79761691
86STK380.79462653
87MTOR0.79241114
88PRKCE0.76805875
89MARK10.76481413
90VRK20.74511558
91CSNK1G30.74284970
92MAPK110.74102831
93RPS6KA60.73809002
94BRSK20.71866707
95LATS10.69683660
96ZAK0.69384475
97EIF2AK20.67382078
98PRKCG0.67307317
99CSNK1A1L0.66879017
100TAF10.65440500
101PIK3CA0.63607033
102PRKAA10.63240935
103GSK3A0.63099344
104CSNK2A10.61711838
105CAMK1G0.60688622
106CDK10.60448285
107DYRK20.59010710
108TAOK20.58192863
109EIF2AK10.57815692
110MET0.55169930
111RPS6KB10.54859503
112FGFR10.54755390
113PRPF4B0.54722859
114NME10.54149475
115BRD40.52415723
116PTK2B0.52194708
117CSNK2A20.52079471
118CDK40.51548039
119RPS6KA10.51471616
120MKNK10.49142142
121MUSK0.49063570
122TESK20.47998236
123ERBB30.47439804
124MAPKAPK30.46809732
125MAPK140.46309282
126PLK30.44865424
127CDK80.44511075
128PHKG20.42881282
129PHKG10.42881282
130NLK0.42879507
131FLT30.42701859
132PKN10.42667949
133STK40.42594287
134MAPK10.42571848
135ADRBK10.41746013
136PRKCI0.41396110
137PASK0.40738540
138PNCK0.40687270
139STK160.40217300
140VRK10.40167243
141MINK10.40099467
142BCKDK0.40083048
143LMTK20.39981368
144MAPK100.38860317
145CDK30.37389552
146CAMK2A0.37284660
147PRKDC0.34249189
148GSK3B0.34129883
149EIF2AK30.32958196
150WNK30.32209963
151CSNK1E0.31569083
152PRKACB0.30996142
153RPS6KA50.30481165
154CSNK1D0.30474828
155RPS6KA40.29205685
156AKT10.28935884
157OBSCN0.28866583
158ALK0.28569105
159DYRK1A0.28351195
160BRSK10.28179680
161MAPK30.24717873

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.29084615
2DNA replication_Homo sapiens_hsa030304.53324058
3Base excision repair_Homo sapiens_hsa034104.19484039
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.47908072
5Fanconi anemia pathway_Homo sapiens_hsa034603.38151810
6Fatty acid biosynthesis_Homo sapiens_hsa000613.08183246
7Nucleotide excision repair_Homo sapiens_hsa034203.02541971
8RNA transport_Homo sapiens_hsa030133.01360732
9Homologous recombination_Homo sapiens_hsa034402.97157675
10Spliceosome_Homo sapiens_hsa030402.83111412
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.78941602
12mRNA surveillance pathway_Homo sapiens_hsa030152.55372768
13Cell cycle_Homo sapiens_hsa041102.45124681
14Protein export_Homo sapiens_hsa030602.34297605
15Propanoate metabolism_Homo sapiens_hsa006402.16537626
16Basal transcription factors_Homo sapiens_hsa030222.05895475
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03468349
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99107089
19p53 signaling pathway_Homo sapiens_hsa041151.88075241
20RNA polymerase_Homo sapiens_hsa030201.85174187
21Butanoate metabolism_Homo sapiens_hsa006501.84982907
22Phototransduction_Homo sapiens_hsa047441.83982444
23Hedgehog signaling pathway_Homo sapiens_hsa043401.65221881
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63523407
25One carbon pool by folate_Homo sapiens_hsa006701.57244614
26Hippo signaling pathway_Homo sapiens_hsa043901.56256676
27RNA degradation_Homo sapiens_hsa030181.49933335
28Steroid biosynthesis_Homo sapiens_hsa001001.49674983
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45666625
30Nicotine addiction_Homo sapiens_hsa050331.45195422
31Oocyte meiosis_Homo sapiens_hsa041141.45023677
32Circadian rhythm_Homo sapiens_hsa047101.43621552
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38022798
34Notch signaling pathway_Homo sapiens_hsa043301.35955418
35Tryptophan metabolism_Homo sapiens_hsa003801.33830446
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32787787
37Non-homologous end-joining_Homo sapiens_hsa034501.32554268
38Basal cell carcinoma_Homo sapiens_hsa052171.31529674
39Pyrimidine metabolism_Homo sapiens_hsa002401.29803498
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25578567
41Proteasome_Homo sapiens_hsa030501.23199073
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22814376
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22079026
44mTOR signaling pathway_Homo sapiens_hsa041501.20917037
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19012393
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18511572
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.17901305
48Adherens junction_Homo sapiens_hsa045201.16037539
49Nitrogen metabolism_Homo sapiens_hsa009101.15073047
50TGF-beta signaling pathway_Homo sapiens_hsa043501.14811618
51Ribosome_Homo sapiens_hsa030101.11369861
52Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11326027
53Wnt signaling pathway_Homo sapiens_hsa043101.07439186
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05234737
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02492258
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98847893
57Oxidative phosphorylation_Homo sapiens_hsa001900.98165964
58beta-Alanine metabolism_Homo sapiens_hsa004100.96672254
59Biosynthesis of amino acids_Homo sapiens_hsa012300.94765547
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.94027808
61Taste transduction_Homo sapiens_hsa047420.91589329
62Retinol metabolism_Homo sapiens_hsa008300.91427382
63Peroxisome_Homo sapiens_hsa041460.90320234
64Fatty acid degradation_Homo sapiens_hsa000710.89960033
65Caffeine metabolism_Homo sapiens_hsa002320.89912618
66Pyruvate metabolism_Homo sapiens_hsa006200.89609484
67Parkinsons disease_Homo sapiens_hsa050120.89288802
68Fatty acid elongation_Homo sapiens_hsa000620.87845865
69Arginine and proline metabolism_Homo sapiens_hsa003300.87057261
70Olfactory transduction_Homo sapiens_hsa047400.86204287
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85654090
72Fatty acid metabolism_Homo sapiens_hsa012120.85238972
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82875198
74Ether lipid metabolism_Homo sapiens_hsa005650.81642372
75Systemic lupus erythematosus_Homo sapiens_hsa053220.80440317
76Chemical carcinogenesis_Homo sapiens_hsa052040.80008329
77Viral carcinogenesis_Homo sapiens_hsa052030.78642822
78Fructose and mannose metabolism_Homo sapiens_hsa000510.77967458
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77086100
80MicroRNAs in cancer_Homo sapiens_hsa052060.76986102
81Colorectal cancer_Homo sapiens_hsa052100.74127739
82Purine metabolism_Homo sapiens_hsa002300.70028933
83Epstein-Barr virus infection_Homo sapiens_hsa051690.69367472
84Bladder cancer_Homo sapiens_hsa052190.69276989
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68980419
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68533617
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68070456
88Folate biosynthesis_Homo sapiens_hsa007900.67772486
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66249666
90Metabolic pathways_Homo sapiens_hsa011000.64864330
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64806545
92ABC transporters_Homo sapiens_hsa020100.64647449
93Dorso-ventral axis formation_Homo sapiens_hsa043200.64603158
94Regulation of autophagy_Homo sapiens_hsa041400.63686019
95Herpes simplex infection_Homo sapiens_hsa051680.63066395
96Lysine degradation_Homo sapiens_hsa003100.62097576
97Morphine addiction_Homo sapiens_hsa050320.60103986
98Sulfur relay system_Homo sapiens_hsa041220.58732338
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58276680
100Vitamin B6 metabolism_Homo sapiens_hsa007500.57808988
101Histidine metabolism_Homo sapiens_hsa003400.57463230
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54880711
103GABAergic synapse_Homo sapiens_hsa047270.54873602
104Glycerolipid metabolism_Homo sapiens_hsa005610.54309939
105Serotonergic synapse_Homo sapiens_hsa047260.53210355
106Tight junction_Homo sapiens_hsa045300.52155408
107Fat digestion and absorption_Homo sapiens_hsa049750.51342280
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49427816
109Vitamin digestion and absorption_Homo sapiens_hsa049770.48724841
110Thyroid cancer_Homo sapiens_hsa052160.48184127
111HTLV-I infection_Homo sapiens_hsa051660.47610372
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46407138
113Shigellosis_Homo sapiens_hsa051310.43838408
114Circadian entrainment_Homo sapiens_hsa047130.43451910
115Glutamatergic synapse_Homo sapiens_hsa047240.43071079
116Small cell lung cancer_Homo sapiens_hsa052220.40991596
117Primary immunodeficiency_Homo sapiens_hsa053400.40672365
118Selenocompound metabolism_Homo sapiens_hsa004500.39800689
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39453375
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.37139960
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36944475
122Alcoholism_Homo sapiens_hsa050340.35770775
123Pathways in cancer_Homo sapiens_hsa052000.31886981
124Choline metabolism in cancer_Homo sapiens_hsa052310.31753361
125Linoleic acid metabolism_Homo sapiens_hsa005910.31538802
126VEGF signaling pathway_Homo sapiens_hsa043700.30675966
127Legionellosis_Homo sapiens_hsa051340.28840249
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.28813851
129ErbB signaling pathway_Homo sapiens_hsa040120.27361312
130AMPK signaling pathway_Homo sapiens_hsa041520.26989631
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.26480752
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.25859762
133Prostate cancer_Homo sapiens_hsa052150.25067342
134Galactose metabolism_Homo sapiens_hsa000520.24195704
135Glutathione metabolism_Homo sapiens_hsa004800.23584971
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23218537
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22200953
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19986353
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19926386
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18483287
1412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.18222533
142Viral myocarditis_Homo sapiens_hsa054160.17564275
143Huntingtons disease_Homo sapiens_hsa050160.16648181
144Endometrial cancer_Homo sapiens_hsa052130.16454697
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16327005
146Acute myeloid leukemia_Homo sapiens_hsa052210.16101292
147Melanoma_Homo sapiens_hsa052180.15136457
148Glucagon signaling pathway_Homo sapiens_hsa049220.13820910
149MAPK signaling pathway_Homo sapiens_hsa040100.13222764
150Insulin signaling pathway_Homo sapiens_hsa049100.12987015
151Arachidonic acid metabolism_Homo sapiens_hsa005900.12616054
152Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12562357
153Gap junction_Homo sapiens_hsa045400.10967600
154HIF-1 signaling pathway_Homo sapiens_hsa040660.10877272

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