RANBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.02905779
2nuclear pore organization (GO:0006999)6.33340877
3pore complex assembly (GO:0046931)5.16735006
4mitotic sister chromatid cohesion (GO:0007064)5.05292205
5regulation of RNA export from nucleus (GO:0046831)4.56509384
6pre-miRNA processing (GO:0031054)4.39114212
7cytoplasmic mRNA processing body assembly (GO:0033962)4.12350471
8monoubiquitinated protein deubiquitination (GO:0035520)4.00124829
9regulation of nucleobase-containing compound transport (GO:0032239)3.94854018
10protein targeting to Golgi (GO:0000042)3.88071718
11establishment of protein localization to Golgi (GO:0072600)3.87198168
12negative regulation of histone methylation (GO:0031061)3.86542885
13NLS-bearing protein import into nucleus (GO:0006607)3.86318937
14regulation of histone H3-K9 methylation (GO:0051570)3.79491516
15dosage compensation (GO:0007549)3.77233542
16retrograde transport, vesicle recycling within Golgi (GO:0000301)3.76213500
17mitotic chromosome condensation (GO:0007076)3.72913022
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.70288125
19regulation of protein polyubiquitination (GO:1902914)3.69258175
20regulation of DNA endoreduplication (GO:0032875)3.67113627
21non-recombinational repair (GO:0000726)3.64179182
22double-strand break repair via nonhomologous end joining (GO:0006303)3.64179182
23positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.51189375
24positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.51189375
25positive regulation of mitotic sister chromatid separation (GO:1901970)3.51189375
26peptidyl-lysine dimethylation (GO:0018027)3.44882557
27protein localization to kinetochore (GO:0034501)3.39675213
28chromatin assembly (GO:0031497)3.37494194
29ribosome assembly (GO:0042255)3.35971121
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.32540566
31regulation of translational termination (GO:0006449)3.31913534
32histone H3-K36 demethylation (GO:0070544)3.27408265
33DNA duplex unwinding (GO:0032508)3.24214061
34DNA geometric change (GO:0032392)3.23759146
35positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.22366947
36nucleus organization (GO:0006997)3.21505660
37positive regulation of DNA-templated transcription, initiation (GO:2000144)3.18278555
38histone H3-K9 demethylation (GO:0033169)3.16593340
39regulation of translational fidelity (GO:0006450)3.14432272
40regulation of mitotic spindle organization (GO:0060236)3.14179355
41negative regulation of DNA repair (GO:0045738)3.12768677
42sister chromatid segregation (GO:0000819)3.10344729
43negative regulation of fibroblast apoptotic process (GO:2000270)3.07792788
44histone H2A monoubiquitination (GO:0035518)3.07741317
45regulation of centriole replication (GO:0046599)3.06097306
46glucocorticoid receptor signaling pathway (GO:0042921)3.04996377
47heterochromatin organization (GO:0070828)3.04529626
48regulation of sister chromatid cohesion (GO:0007063)3.03886640
49phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.03327684
50embryonic camera-type eye morphogenesis (GO:0048596)3.01074471
51DNA unwinding involved in DNA replication (GO:0006268)3.00916445
52histone mRNA catabolic process (GO:0071044)2.99743484
53positive regulation of histone deacetylation (GO:0031065)2.97466706
54* mitotic nuclear envelope disassembly (GO:0007077)2.96981824
55interkinetic nuclear migration (GO:0022027)2.96504020
56mRNA stabilization (GO:0048255)2.96296026
57RNA stabilization (GO:0043489)2.96296026
58* membrane disassembly (GO:0030397)2.96137044
59* nuclear envelope disassembly (GO:0051081)2.96137044
60regulation of spindle organization (GO:0090224)2.94261388
61genitalia morphogenesis (GO:0035112)2.91917261
62histone lysine demethylation (GO:0070076)2.89936446
63COPII vesicle coating (GO:0048208)2.89889529
64gene silencing by RNA (GO:0031047)2.89050672
65mitotic sister chromatid segregation (GO:0000070)2.87724976
66definitive hemopoiesis (GO:0060216)2.83750421
67corticosteroid receptor signaling pathway (GO:0031958)2.83147788
68folic acid-containing compound biosynthetic process (GO:0009396)2.83129585
69regulation of histone H3-K27 methylation (GO:0061085)2.83075784
70dorsal/ventral axis specification (GO:0009950)2.82012065
71protein localization to chromosome, centromeric region (GO:0071459)2.81904306
72positive regulation of chromosome segregation (GO:0051984)2.80587977
73regulation of transforming growth factor beta2 production (GO:0032909)2.78035072
74Golgi transport vesicle coating (GO:0048200)2.76827875
75COPI coating of Golgi vesicle (GO:0048205)2.76827875
76histone demethylation (GO:0016577)2.75736341
77peptidyl-lysine trimethylation (GO:0018023)2.73118146
78metaphase plate congression (GO:0051310)2.71987458
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.71542406
80regulation of chromosome segregation (GO:0051983)2.69785608
81positive regulation of cell cycle checkpoint (GO:1901978)2.66840820
82sister chromatid cohesion (GO:0007062)2.65871632
83negative regulation of histone modification (GO:0031057)2.65465591
84paraxial mesoderm development (GO:0048339)2.64912178
85mitotic metaphase plate congression (GO:0007080)2.64332192
86translesion synthesis (GO:0019985)2.63906842
87spliceosomal tri-snRNP complex assembly (GO:0000244)2.63190258
88morphogenesis of an epithelial sheet (GO:0002011)2.62855983
89embryonic foregut morphogenesis (GO:0048617)2.62251717
90embryonic retina morphogenesis in camera-type eye (GO:0060059)2.61837710
91response to UV-C (GO:0010225)2.60494376
92spindle assembly involved in mitosis (GO:0090307)2.60330202
93growth hormone receptor signaling pathway (GO:0060396)2.59971284
94DNA synthesis involved in DNA repair (GO:0000731)2.59750638
95gene silencing (GO:0016458)2.57542952
96regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.57536327
97regulation of mitotic metaphase/anaphase transition (GO:0030071)2.57536327
98bundle of His cell to Purkinje myocyte communication (GO:0086069)2.56318885
99gastrulation with mouth forming second (GO:0001702)2.56072858
100regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.55811001
101insulin-like growth factor receptor signaling pathway (GO:0048009)2.53782719
102DNA conformation change (GO:0071103)2.53686018
103regulation of mitotic sister chromatid separation (GO:0010965)2.53383761
104regulation of mitotic sister chromatid segregation (GO:0033047)2.53383761
105regulation of sister chromatid segregation (GO:0033045)2.53383761
106centrosome duplication (GO:0051298)2.53026341
107negative regulation of chromatin modification (GO:1903309)2.52425813
108positive regulation of SMAD protein import into nucleus (GO:0060391)2.50961767
109regulation of centrosome duplication (GO:0010824)2.50817696
110germ cell migration (GO:0008354)2.50110908
111regulation of establishment of cell polarity (GO:2000114)2.50012573
112microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.49433660
113regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.49349077
114protein localization to endosome (GO:0036010)2.47847241
115Golgi to endosome transport (GO:0006895)2.47173679
116nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.46034209
117* mRNA transport (GO:0051028)2.45045527
118N-terminal protein amino acid acetylation (GO:0006474)2.44287792
119positive regulation of catenin import into nucleus (GO:0035413)2.43995316
120regulation of DNA damage checkpoint (GO:2000001)2.43605023
121histone H3-K9 methylation (GO:0051567)2.43518036
122protein demethylation (GO:0006482)2.43360709
123protein dealkylation (GO:0008214)2.43360709
124chromosome condensation (GO:0030261)2.42839085
125establishment of chromosome localization (GO:0051303)2.42815897
126histone H2B ubiquitination (GO:0033523)2.42557934
127protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.42144420
128activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.41694549
129embryonic process involved in female pregnancy (GO:0060136)2.41323175
130DNA topological change (GO:0006265)2.40544514
131regulation of interleukin-12 biosynthetic process (GO:0045075)2.40028255
132protein K48-linked deubiquitination (GO:0071108)2.39995851
133coronary vasculature morphogenesis (GO:0060977)2.39344427
134glomerular visceral epithelial cell development (GO:0072015)2.39330755
135positive regulation of nuclease activity (GO:0032075)2.39322779
136protein export from nucleus (GO:0006611)2.38058148
137chromatin assembly or disassembly (GO:0006333)2.37388955
138* nuclear envelope organization (GO:0006998)2.36624427
139stress granule assembly (GO:0034063)2.36209592
140cellular response to interferon-alpha (GO:0035457)2.35598169
141positive regulation of protein import into nucleus, translocation (GO:0033160)2.35517965
142regulation of centrosome cycle (GO:0046605)2.34182098
143DNA replication-dependent nucleosome assembly (GO:0006335)2.33067209
144DNA replication-dependent nucleosome organization (GO:0034723)2.33067209
145macroautophagy (GO:0016236)2.32822316
146response to epidermal growth factor (GO:0070849)2.32358676
147histone H3-K9 modification (GO:0061647)2.30222835
148negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.29955257
149positive regulation of gamma-delta T cell activation (GO:0046645)2.29864546
150DNA packaging (GO:0006323)2.27640904

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.47621166
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.44904008
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.85852386
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.85411605
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.12258213
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.20806473
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.96963590
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.92837162
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.79066373
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.71715188
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.52275244
12GATA1_22025678_ChIP-Seq_K562_Human2.39491905
13MYC_22102868_ChIP-Seq_BL_Human2.36783630
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16912741
15* E2F1_21310950_ChIP-Seq_MCF-7_Human2.07499425
16AR_21909140_ChIP-Seq_LNCAP_Human1.92726883
17FUS_26573619_Chip-Seq_HEK293_Human1.89859422
18* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88052506
19ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.80434618
20WT1_19549856_ChIP-ChIP_CCG9911_Human1.79673658
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.77639289
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76437690
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75625012
24CLOCK_20551151_ChIP-Seq_293T_Human1.74334073
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68185055
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.66893396
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65786835
28TCF7_22412390_ChIP-Seq_EML_Mouse1.61739574
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55570976
30TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.49369633
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.44100130
32HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42832102
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42146681
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40121189
35FOXM1_26456572_ChIP-Seq_MCF-7_Human1.38181106
36* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37749351
37CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36302336
38EWS_26573619_Chip-Seq_HEK293_Human1.35705263
39* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34808604
40FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.33039383
41MYB_26560356_Chip-Seq_TH1_Human1.32655656
42* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31815382
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31715546
44* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31016065
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30586557
46PKCTHETA_26484144_Chip-Seq_BREAST_Human1.29748303
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.29080343
48* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27609608
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27068880
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26640068
51FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.26002380
52MYB_26560356_Chip-Seq_TH2_Human1.25456386
53BRD4_25478319_ChIP-Seq_HGPS_Human1.25237316
54* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24873575
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.24394225
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23971331
57* TCF4_18268006_ChIP-ChIP_LS174T_Human1.22878867
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20450437
59KDM2B_26808549_Chip-Seq_DND41_Human1.19806096
60* STAT3_23295773_ChIP-Seq_U87_Human1.19701231
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19464719
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19077224
63TAF15_26573619_Chip-Seq_HEK293_Human1.18263925
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17455951
65SMAD4_21799915_ChIP-Seq_A2780_Human1.16716638
66TFEB_21752829_ChIP-Seq_HELA_Human1.16186182
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15796212
68* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14907495
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14115597
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12571338
71* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11714949
72* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11714949
73CHD1_26751641_Chip-Seq_LNCaP_Human1.11547515
74* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11009566
75AHR_22903824_ChIP-Seq_MCF-7_Human1.10442089
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10211341
77MAF_26560356_Chip-Seq_TH1_Human1.10201226
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.09251938
79UTX_26944678_Chip-Seq_JUKART_Human1.09186537
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09142662
81FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08328460
82GATA6_25053715_ChIP-Seq_YYC3_Human1.08189693
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05072675
84* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04761836
85MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04731945
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04016973
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03490536
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03462053
89ZNF263_19887448_ChIP-Seq_K562_Human1.03124576
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02620242
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01763716
92EP300_21415370_ChIP-Seq_HL-1_Mouse1.01409264
93* EZH2_27294783_Chip-Seq_NPCs_Mouse1.01293967
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.01265826
95IRF8_27001747_Chip-Seq_BMDM_Mouse1.01048070
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.00840963
97VDR_21846776_ChIP-Seq_THP-1_Human1.00796427
98SMAD3_21741376_ChIP-Seq_EPCs_Human0.99968482
99PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99734011
100NCOR1_26117541_ChIP-Seq_K562_Human0.99483958
101ARNT_22903824_ChIP-Seq_MCF-7_Human0.99428219
102HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99379076
103PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98973808
104NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98309959
105* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97993688
106Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97574643
107TP53_16413492_ChIP-PET_HCT116_Human0.97416825
108KDM5A_27292631_Chip-Seq_BREAST_Human0.97069567
109GBX2_23144817_ChIP-Seq_PC3_Human0.95926344
110P300_19829295_ChIP-Seq_ESCs_Human0.95567888
111* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95460788
112TCF4_23295773_ChIP-Seq_U87_Human0.95208328
113SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94784587
114TP63_19390658_ChIP-ChIP_HaCaT_Human0.91409625
115PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91242877
116FOXA2_19822575_ChIP-Seq_HepG2_Human0.90037633
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89614330
118CBP_20019798_ChIP-Seq_JUKART_Human0.89614330
119GATA3_27048872_Chip-Seq_THYMUS_Human0.88930143
120PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87348873
121SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87059506
122* PU_27001747_Chip-Seq_BMDM_Mouse0.86989003
123CMYC_18555785_Chip-Seq_ESCs_Mouse0.86970162
124SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86935625
125* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.86813617
126ELK1_19687146_ChIP-ChIP_HELA_Human0.86695695
127RUNX_20019798_ChIP-Seq_JUKART_Human0.86655689
128CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86587265
129GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86544217
130SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85786518
131* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85761523
132ATF3_27146783_Chip-Seq_COLON_Human0.85363571
133SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85338321
134IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85332690
135CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85147053
136CDX2_22108803_ChIP-Seq_LS180_Human0.85113814
137CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84518439
138* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84421048
139CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84127391
140NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83978366
141NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83881915
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83881915
143STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83711717
144ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.83566416
145RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82757886
146RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82403681
147UBF1/2_26484160_Chip-Seq_HMECs_Human0.82337484
148KDM2B_26808549_Chip-Seq_JURKAT_Human0.82132214
149* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81571135
150FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.81535978
151STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77482904
152CIITA_25753668_ChIP-Seq_RAJI_Human0.75815551
153PPAR_26484153_Chip-Seq_NCI-H1993_Human0.75693840
154* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.75305925

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.10144929
2MP0010352_gastrointestinal_tract_polyps3.94872556
3MP0003705_abnormal_hypodermis_morpholog3.68213259
4MP0003300_gastrointestinal_ulcer3.39140199
5MP0010234_abnormal_vibrissa_follicle3.17183272
6MP0005076_abnormal_cell_differentiation3.15929245
7* MP0010307_abnormal_tumor_latency2.49426376
8MP0003941_abnormal_skin_development2.47033724
9MP0002877_abnormal_melanocyte_morpholog2.46529112
10MP0002166_altered_tumor_susceptibility2.22371583
11MP0010094_abnormal_chromosome_stability2.14248405
12MP0008057_abnormal_DNA_replication2.08308874
13MP0009697_abnormal_copulation2.03694504
14MP0003566_abnormal_cell_adhesion2.02411246
15MP0004808_abnormal_hematopoietic_stem1.87022142
16MP0008438_abnormal_cutaneous_collagen1.73777458
17MP0002006_tumorigenesis1.73543752
18* MP0003111_abnormal_nucleus_morphology1.70389232
19MP0008877_abnormal_DNA_methylation1.69782810
20MP0003091_abnormal_cell_migration1.64425850
21MP0004197_abnormal_fetal_growth/weight/1.62523056
22MP0002086_abnormal_extraembryonic_tissu1.61274904
23* MP0003077_abnormal_cell_cycle1.60204236
24MP0002396_abnormal_hematopoietic_system1.59802962
25MP0001730_embryonic_growth_arrest1.59695620
26MP0003303_peritoneal_inflammation1.58219980
27MP0002009_preneoplasia1.55990199
28MP0006054_spinal_hemorrhage1.53161320
29MP0000350_abnormal_cell_proliferation1.49593423
30MP0003890_abnormal_embryonic-extraembry1.47901563
31MP0000383_abnormal_hair_follicle1.47712089
32MP0005257_abnormal_intraocular_pressure1.46580255
33MP0002088_abnormal_embryonic_growth/wei1.44674264
34MP0003984_embryonic_growth_retardation1.44443611
35MP0004185_abnormal_adipocyte_glucose1.43870801
36MP0000733_abnormal_muscle_development1.43322205
37MP0001672_abnormal_embryogenesis/_devel1.42380320
38MP0005380_embryogenesis_phenotype1.42380320
39MP0004233_abnormal_muscle_weight1.42264549
40MP0003937_abnormal_limbs/digits/tail_de1.39611399
41MP0003693_abnormal_embryo_hatching1.37550416
42MP0004957_abnormal_blastocyst_morpholog1.35685031
43MP0004264_abnormal_extraembryonic_tissu1.35254965
44MP0003045_fibrosis1.31762716
45MP0002084_abnormal_developmental_patter1.31023102
46MP0008932_abnormal_embryonic_tissue1.30818806
47MP0003121_genomic_imprinting1.30568744
48MP0003787_abnormal_imprinting1.30210807
49MP0005409_darkened_coat_color1.29955368
50MP0009278_abnormal_bone_marrow1.27433780
51MP0003123_paternal_imprinting1.26873918
52MP0005023_abnormal_wound_healing1.25020799
53MP0003252_abnormal_bile_duct1.23368117
54MP0001915_intracranial_hemorrhage1.21717358
55MP0003868_abnormal_feces_composition1.18747081
56MP0004947_skin_inflammation1.16668976
57MP0009703_decreased_birth_body1.15763602
58MP0001697_abnormal_embryo_size1.15273021
59MP0008007_abnormal_cellular_replicative1.15150991
60MP0005275_abnormal_skin_tensile1.14370018
61MP0010678_abnormal_skin_adnexa1.13404979
62MP0001661_extended_life_span1.11149058
63MP0003943_abnormal_hepatobiliary_system1.09774717
64MP0003221_abnormal_cardiomyocyte_apopto1.09229051
65MP0000432_abnormal_head_morphology1.08042479
66MP0000371_diluted_coat_color1.07369002
67MP0001849_ear_inflammation1.05762917
68MP0008961_abnormal_basal_metabolism1.05516536
69MP0003385_abnormal_body_wall1.05232427
70MP0001545_abnormal_hematopoietic_system1.03454277
71MP0005397_hematopoietic_system_phenotyp1.03454277
72* MP0002080_prenatal_lethality1.01716962
73MP0002928_abnormal_bile_duct1.01203935
74MP0009672_abnormal_birth_weight0.97145580
75MP0002085_abnormal_embryonic_tissue0.95663588
76MP0005621_abnormal_cell_physiology0.95268520
77MP0004084_abnormal_cardiac_muscle0.92907672
78MP0002925_abnormal_cardiovascular_devel0.92177049
79MP0003950_abnormal_plasma_membrane0.92017438
80MP0000703_abnormal_thymus_morphology0.90014680
81MP0004272_abnormal_basement_membrane0.89182609
82MP0000428_abnormal_craniofacial_morphol0.87725080
83MP0005666_abnormal_adipose_tissue0.86883126
84MP0005623_abnormal_meninges_morphology0.86240611
85MP0003453_abnormal_keratinocyte_physiol0.85481315
86MP0002398_abnormal_bone_marrow0.85369223
87MP0000003_abnormal_adipose_tissue0.85158428
88MP0001299_abnormal_eye_distance/0.85000607
89MP0003448_altered_tumor_morphology0.83783347
90MP0002269_muscular_atrophy0.82731176
91MP0002092_abnormal_eye_morphology0.81858602
92MP0001286_abnormal_eye_development0.80834359
93MP0004036_abnormal_muscle_relaxation0.80638953
94MP0008004_abnormal_stomach_pH0.80525057
95MP0000427_abnormal_hair_cycle0.80009813
96MP0003567_abnormal_fetal_cardiomyocyte0.79537684
97MP0009053_abnormal_anal_canal0.78597860
98MP0003436_decreased_susceptibility_to0.78405260
99MP0002896_abnormal_bone_mineralization0.77055387
100MP0001784_abnormal_fluid_regulation0.76969244
101MP0001177_atelectasis0.76649984
102MP0000490_abnormal_crypts_of0.76279329
103MP0000377_abnormal_hair_follicle0.75704709
104* MP0002019_abnormal_tumor_incidence0.75464239
105MP0005220_abnormal_exocrine_pancreas0.75230686
106MP0002697_abnormal_eye_size0.75032160
107MP0005375_adipose_tissue_phenotype0.74899603
108MP0005187_abnormal_penis_morphology0.74482770
109MP0001800_abnormal_humoral_immune0.74328264
110MP0005384_cellular_phenotype0.73747924
111MP0003763_abnormal_thymus_physiology0.73708092
112MP0000313_abnormal_cell_death0.73649965
113MP0008058_abnormal_DNA_repair0.73374681
114MP0001293_anophthalmia0.73326758
115MP0010155_abnormal_intestine_physiology0.72870546
116MP0010630_abnormal_cardiac_muscle0.72540127
117MP0003172_abnormal_lysosome_physiology0.72332887
118MP0009780_abnormal_chondrocyte_physiolo0.71965074
119MP0002060_abnormal_skin_morphology0.71847060
120MP0001873_stomach_inflammation0.71693968
121MP0001835_abnormal_antigen_presentation0.71102022
122MP0003656_abnormal_erythrocyte_physiolo0.70074661
123MP0003115_abnormal_respiratory_system0.69643904
124MP0000627_abnormal_mammary_gland0.69299418
125MP0000537_abnormal_urethra_morphology0.69192904
126MP0000609_abnormal_liver_physiology0.68123510
127MP0000266_abnormal_heart_morphology0.67935532
128MP0001666_abnormal_nutrient_absorption0.67613977
129MP0005451_abnormal_body_composition0.67255890
130MP0003935_abnormal_craniofacial_develop0.67147224
131MP0001929_abnormal_gametogenesis0.64733182
132MP0010368_abnormal_lymphatic_system0.63950104
133MP0002233_abnormal_nose_morphology0.63491480
134MP0004087_abnormal_muscle_fiber0.63324899
135MP0002796_impaired_skin_barrier0.62930437

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.43586344
2Volvulus (HP:0002580)3.41725357
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.32746694
4Abnormality of the fingertips (HP:0001211)3.27047398
5Subacute progressive viral hepatitis (HP:0006572)3.17555396
6Nephroblastoma (Wilms tumor) (HP:0002667)3.04349106
7Macroorchidism (HP:0000053)3.04091344
8Cerebral aneurysm (HP:0004944)3.01084492
9Rhabdomyosarcoma (HP:0002859)3.00148727
10Embryonal renal neoplasm (HP:0011794)2.92445464
11Thyroid carcinoma (HP:0002890)2.81543726
12Absent frontal sinuses (HP:0002688)2.77913966
13Hematochezia (HP:0002573)2.70783068
14Medulloblastoma (HP:0002885)2.67650756
15Heterotopia (HP:0002282)2.56500446
16Hepatoblastoma (HP:0002884)2.49887337
17Biliary tract neoplasm (HP:0100574)2.40035287
18Aortic aneurysm (HP:0004942)2.36315433
19Abnormality of the astrocytes (HP:0100707)2.35179856
20Astrocytoma (HP:0009592)2.35179856
21Truncal obesity (HP:0001956)2.35045407
22Increased density of long bones (HP:0006392)2.34472133
23Papillary thyroid carcinoma (HP:0002895)2.33728822
24Neoplasm of the small intestine (HP:0100833)2.33029402
25Dysmetric saccades (HP:0000641)2.32311577
26Termporal pattern (HP:0011008)2.29352928
27Insidious onset (HP:0003587)2.29352928
28Mitral valve prolapse (HP:0001634)2.26434842
29Overgrowth (HP:0001548)2.25510893
30Sandal gap (HP:0001852)2.25470874
31Ependymoma (HP:0002888)2.21680702
32Relative macrocephaly (HP:0004482)2.21508111
33Short 4th metacarpal (HP:0010044)2.21002518
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.21002518
35Long eyelashes (HP:0000527)2.19882007
36Curly hair (HP:0002212)2.18554695
37Neoplasm of striated muscle (HP:0009728)2.17735496
38Deviation of the thumb (HP:0009603)2.14929711
39Prominent nose (HP:0000448)2.14260302
40Tubulointerstitial nephritis (HP:0001970)2.10683200
41Osteolytic defects of the hand bones (HP:0009699)2.09935595
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.09935595
43High pitched voice (HP:0001620)2.08976991
44Anal stenosis (HP:0002025)2.08397164
45Malignant gastrointestinal tract tumors (HP:0006749)2.08390926
46Gastrointestinal carcinoma (HP:0002672)2.08390926
47Neonatal hypoglycemia (HP:0001998)2.07881634
48Aneurysm (HP:0002617)2.07299073
49Overlapping toe (HP:0001845)2.07248365
50Ankle contracture (HP:0006466)2.06837900
51Uterine leiomyosarcoma (HP:0002891)2.06248028
52Leiomyosarcoma (HP:0100243)2.06248028
53Narrow palate (HP:0000189)2.04589666
54Persistence of primary teeth (HP:0006335)2.04484477
55Resting tremor (HP:0002322)2.03417607
56Abnormality of chromosome segregation (HP:0002916)2.02552019
57Obsessive-compulsive behavior (HP:0000722)2.02486887
58Urethral obstruction (HP:0000796)2.02452588
59Cystic hygroma (HP:0000476)2.02199947
60Asymmetry of the thorax (HP:0001555)2.02119072
61Hypochromic microcytic anemia (HP:0004840)2.01127176
62Subaortic stenosis (HP:0001682)2.00408938
63Abnormality of the left ventricular outflow tract (HP:0011103)2.00408938
64Vertebral arch anomaly (HP:0008438)2.00356360
65Ulnar bowing (HP:0003031)2.00034068
66Rectal prolapse (HP:0002035)1.99351627
67Cutaneous melanoma (HP:0012056)1.98762041
68Right ventricular cardiomyopathy (HP:0011663)1.97193247
69Dilatation of the ascending aorta (HP:0005111)1.95908231
70Hypopigmentation of the fundus (HP:0007894)1.91393120
71Deep philtrum (HP:0002002)1.91328897
72Hyperacusis (HP:0010780)1.91314059
73Long clavicles (HP:0000890)1.91223249
74Difficulty running (HP:0009046)1.91150869
75Shallow orbits (HP:0000586)1.91008410
76Proximal placement of thumb (HP:0009623)1.90960841
77Enlarged penis (HP:0000040)1.90868165
78Renovascular hypertension (HP:0100817)1.90262479
79Bowel diverticulosis (HP:0005222)1.88797839
80Increased nuchal translucency (HP:0010880)1.87577241
81Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.86109996
82Submucous cleft hard palate (HP:0000176)1.84958540
83Cervical subluxation (HP:0003308)1.83612764
84Increased mean platelet volume (HP:0011877)1.83262393
85Acute myeloid leukemia (HP:0004808)1.82673214
86Embryonal neoplasm (HP:0002898)1.82221821
87Radial bowing (HP:0002986)1.81936574
88Abnormal pancreas size (HP:0012094)1.81397703
89Transitional cell carcinoma of the bladder (HP:0006740)1.81234095
90Glioma (HP:0009733)1.81186183
91Abnormal foot bone ossification (HP:0010675)1.79793156
92Cubitus valgus (HP:0002967)1.79681654
93Metaphyseal cupping (HP:0003021)1.78749185
94Abnormality of oral frenula (HP:0000190)1.78128731
95Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78101904
96Abnormality of the labia majora (HP:0012881)1.77182817
97Short chin (HP:0000331)1.76452576
98Abnormality of the ischium (HP:0003174)1.75278856
99Cortical dysplasia (HP:0002539)1.74953712
100Low anterior hairline (HP:0000294)1.74626571
101Broad thumb (HP:0011304)1.74602246
102Myocardial infarction (HP:0001658)1.74368310
103Missing ribs (HP:0000921)1.74336734
104Germ cell neoplasia (HP:0100728)1.73142634
105Abnormality of the preputium (HP:0100587)1.72683000
106Bladder carcinoma (HP:0002862)1.70613176
107Bladder neoplasm (HP:0009725)1.70613176
108Spastic diplegia (HP:0001264)1.70191837
109Menstrual irregularities (HP:0000858)1.69641942
110Abnormality of the epiphyses of the hand (HP:0005924)1.69382139
111Viral hepatitis (HP:0006562)1.68748259
112Fair hair (HP:0002286)1.68547919
113Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.67440862
114Limited elbow extension (HP:0001377)1.66693383
115Hypoplastic ischia (HP:0003175)1.66692745
116Abnormal platelet volume (HP:0011876)1.66057096
117Syringomyelia (HP:0003396)1.65831813
118Spinal cord lesions (HP:0100561)1.65831813
119Advanced eruption of teeth (HP:0006288)1.65624651
120Cutis marmorata (HP:0000965)1.64714849
121Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.64615774
122Pelvic girdle muscle weakness (HP:0003749)1.64492669
123Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.64324851
124Hypoplastic labia majora (HP:0000059)1.62945407
125Neoplasm of the oral cavity (HP:0100649)1.62686610
126Exostoses (HP:0100777)1.62541612
127Large earlobe (HP:0009748)1.62418691
128Hand muscle atrophy (HP:0009130)1.62205751
129Tetraparesis (HP:0002273)1.61660360
130Abnormal hair whorl (HP:0010721)1.60728451
131Colon cancer (HP:0003003)1.60647873
132Genu recurvatum (HP:0002816)1.60433283
133Abnormality of the peritoneum (HP:0002585)1.60189463
134Abnormal biliary tract morphology (HP:0012440)1.60050983
135Myelodysplasia (HP:0002863)1.59932348
136Arterial thrombosis (HP:0004420)1.59845163
137Ankyloglossia (HP:0010296)1.59479857
138Cafe-au-lait spot (HP:0000957)1.58779878
139Abnormality of the lower motor neuron (HP:0002366)1.58712508
140Abnormality of the 4th metacarpal (HP:0010012)1.58105300
141Aplasia/Hypoplasia of the uvula (HP:0010293)1.57964343
142Fibrous tissue neoplasm (HP:0012316)1.57818728
143Smooth philtrum (HP:0000319)1.57128190
144Micronodular cirrhosis (HP:0001413)1.56581138
145IgA deficiency (HP:0002720)1.56504710
146Abnormality of chromosome stability (HP:0003220)1.56450165
147Frequent falls (HP:0002359)1.56299550
148Abnormality of the nasal septum (HP:0000419)1.56245334
149Abnormality of the calcaneus (HP:0008364)1.56204351
150Skull defect (HP:0001362)1.55254662
151Thick eyebrow (HP:0000574)1.55067911
152Uterine neoplasm (HP:0010784)1.54815755
153Selective tooth agenesis (HP:0001592)1.54792013
154Severe short stature (HP:0003510)1.54573987

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.37643139
2SCYL22.78984889
3PKN22.73008180
4EEF2K2.72212579
5AKT32.67289315
6CDC72.67108887
7LATS12.66763358
8EIF2AK32.58852829
9MKNK22.53553349
10PLK42.28395649
11FRK2.28210310
12CAMK1D2.22562298
13TTN2.15438154
14TRIB32.12899646
15PNCK2.11718072
16MAP3K102.02789839
17MKNK12.01915603
18FGFR31.91246065
19RIPK11.90580605
20BRD41.89382146
21NEK21.87032050
22STK38L1.84837845
23PTK61.74439221
24PDGFRA1.72755297
25PBK1.67569102
26STK31.65877682
27CDK61.64402608
28CAMK1G1.61150677
29MST1R1.60559040
30STK101.45378001
31NLK1.40862843
32MTOR1.37496754
33FGFR41.36427516
34JAK11.33050851
35TAOK31.32721984
36SIK11.30838034
37NEK11.29869106
38FGFR21.29246585
39ALK1.27410278
40JAK31.26670980
41PDGFRB1.22731458
42LATS21.16259183
43MELK1.15544907
44STK391.14528268
45PASK1.14428020
46CDK41.12893911
47MET1.12320432
48FLT31.12126574
49ATR1.11076321
50NEK61.10429864
51YES11.08232935
52RPS6KB21.07054281
53TNIK1.06361653
54ATM0.95607020
55MAP3K80.95553582
56FGFR10.95500325
57CDK90.94643411
58TTK0.93937516
59NUAK10.91127080
60MAP3K20.90719210
61* CHEK10.90295470
62ERBB30.88561784
63TAF10.87269046
64TYK20.86014886
65STK40.84447418
66LRRK20.83793733
67RPS6KA40.82900336
68STK240.82660060
69AURKB0.82525774
70RET0.81898702
71ACVR1B0.81758881
72MAP4K10.80742466
73SGK30.80602361
74CHUK0.80600003
75PIM10.80141537
76BRSK20.79058246
77PAK20.77059594
78MST40.75223277
79BMX0.74399248
80ICK0.73452781
81ITK0.72414031
82EIF2AK10.71787773
83OBSCN0.71333723
84JAK20.70885727
85TRPM70.69940476
86NEK90.66583358
87MAP3K40.64483604
88* CDK20.62400658
89ZAK0.62314173
90DDR20.62137557
91KSR10.61224100
92ERBB40.59942811
93MARK30.59853206
94MAP3K140.58900413
95MAP3K30.57837757
96PRKAA20.57670557
97TGFBR10.57328391
98PLK30.57146754
99PRKDC0.57107997
100CDK70.56714996
101SRPK10.56594454
102CSNK1E0.54783865
103EGFR0.54499381
104FER0.54313515
105EPHA30.53841812
106CDK30.52835067
107PIK3CA0.51748266
108ERN10.51490080
109CHEK20.51008611
110EIF2AK20.50805068
111SGK10.50241085
112MAP2K30.49507957
113RPS6KB10.49137944
114* CDK10.48386854
115HCK0.48045425
116WEE10.48014365
117TGFBR20.47181494
118EPHA20.46966601
119SIK20.46512113
120TSSK60.46443012
121* GSK3B0.45290537
122PLK10.45254839
123* MAPK140.45065814
124MAP3K70.44993351
125HIPK20.44844211
126SGK20.44271871
127* CSNK1D0.44154424
128TEC0.43919389
129KSR20.43010175
130BCR0.42949513
131PIK3CG0.42490531
132PLK20.41653237
133WNK10.41496078
134INSRR0.41469997
135CSF1R0.41462956
136CLK10.39688421
137PTK20.39650975
138DMPK0.38921156
139MAPK100.38300157
140AKT10.37497511
141PRKAA10.36508001

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053222.22533918
2Lysine degradation_Homo sapiens_hsa003101.97148099
3mTOR signaling pathway_Homo sapiens_hsa041501.77983226
4Chronic myeloid leukemia_Homo sapiens_hsa052201.74778948
5One carbon pool by folate_Homo sapiens_hsa006701.68019024
6Small cell lung cancer_Homo sapiens_hsa052221.66768757
7MicroRNAs in cancer_Homo sapiens_hsa052061.63851042
8Viral carcinogenesis_Homo sapiens_hsa052031.62979963
9Nitrogen metabolism_Homo sapiens_hsa009101.62125829
10Mismatch repair_Homo sapiens_hsa034301.51399859
11Selenocompound metabolism_Homo sapiens_hsa004501.50813828
12Antigen processing and presentation_Homo sapiens_hsa046121.44750323
13Adherens junction_Homo sapiens_hsa045201.39213495
14Cell cycle_Homo sapiens_hsa041101.35633085
15Circadian rhythm_Homo sapiens_hsa047101.35515579
16DNA replication_Homo sapiens_hsa030301.34487809
17Type II diabetes mellitus_Homo sapiens_hsa049301.32976159
18Proteoglycans in cancer_Homo sapiens_hsa052051.29807301
19Insulin resistance_Homo sapiens_hsa049311.29523430
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29452796
21Fatty acid biosynthesis_Homo sapiens_hsa000611.25681035
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.23941453
23mRNA surveillance pathway_Homo sapiens_hsa030151.23365217
24Pancreatic cancer_Homo sapiens_hsa052121.21802651
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18187272
26Dorso-ventral axis formation_Homo sapiens_hsa043201.16475292
27Non-small cell lung cancer_Homo sapiens_hsa052231.16414262
28Toxoplasmosis_Homo sapiens_hsa051451.15468493
29Focal adhesion_Homo sapiens_hsa045101.14708274
30ErbB signaling pathway_Homo sapiens_hsa040121.10829618
31Spliceosome_Homo sapiens_hsa030401.10676073
32Prostate cancer_Homo sapiens_hsa052151.10145005
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09115216
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.08969378
35* RNA transport_Homo sapiens_hsa030131.08657986
36HTLV-I infection_Homo sapiens_hsa051661.07071809
37Hepatitis B_Homo sapiens_hsa051611.06943216
38Osteoclast differentiation_Homo sapiens_hsa043801.06892314
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04320030
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04170082
41Endometrial cancer_Homo sapiens_hsa052131.04011781
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03408864
43B cell receptor signaling pathway_Homo sapiens_hsa046621.02651888
44Herpes simplex infection_Homo sapiens_hsa051681.02245946
45Measles_Homo sapiens_hsa051621.01542212
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00967030
47Glioma_Homo sapiens_hsa052140.99439493
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98729293
49Basal transcription factors_Homo sapiens_hsa030220.98343623
50TNF signaling pathway_Homo sapiens_hsa046680.97078283
51Influenza A_Homo sapiens_hsa051640.97021438
52p53 signaling pathway_Homo sapiens_hsa041150.96780528
53Nucleotide excision repair_Homo sapiens_hsa034200.96201281
54FoxO signaling pathway_Homo sapiens_hsa040680.95863832
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94061362
56Alcoholism_Homo sapiens_hsa050340.93719422
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92428464
58Colorectal cancer_Homo sapiens_hsa052100.91317590
59Prolactin signaling pathway_Homo sapiens_hsa049170.90503564
60Long-term potentiation_Homo sapiens_hsa047200.89630850
61ECM-receptor interaction_Homo sapiens_hsa045120.89494057
62Apoptosis_Homo sapiens_hsa042100.88914294
63RNA degradation_Homo sapiens_hsa030180.88843809
64Tight junction_Homo sapiens_hsa045300.88721187
65Leishmaniasis_Homo sapiens_hsa051400.88552115
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88485742
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.87443765
68Viral myocarditis_Homo sapiens_hsa054160.87415211
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.86976765
70Acute myeloid leukemia_Homo sapiens_hsa052210.86929364
71T cell receptor signaling pathway_Homo sapiens_hsa046600.86537326
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85319967
73TGF-beta signaling pathway_Homo sapiens_hsa043500.83419273
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83226581
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83131725
76Amoebiasis_Homo sapiens_hsa051460.81988129
77Choline metabolism in cancer_Homo sapiens_hsa052310.81279907
78Wnt signaling pathway_Homo sapiens_hsa043100.80484577
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79550730
80Inositol phosphate metabolism_Homo sapiens_hsa005620.79287483
81AMPK signaling pathway_Homo sapiens_hsa041520.79207898
82Non-homologous end-joining_Homo sapiens_hsa034500.78284682
83Legionellosis_Homo sapiens_hsa051340.76671286
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76471920
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.76143038
86Platelet activation_Homo sapiens_hsa046110.75718767
87HIF-1 signaling pathway_Homo sapiens_hsa040660.73013349
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.72483267
89Glucagon signaling pathway_Homo sapiens_hsa049220.72271413
90Insulin signaling pathway_Homo sapiens_hsa049100.71687669
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70676464
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69655229
93Thyroid cancer_Homo sapiens_hsa052160.68756609
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67012331
95Renal cell carcinoma_Homo sapiens_hsa052110.66324189
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66261902
97Melanoma_Homo sapiens_hsa052180.66068952
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65421375
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65042371
100Estrogen signaling pathway_Homo sapiens_hsa049150.64195305
101Hepatitis C_Homo sapiens_hsa051600.63861439
102Thyroid hormone synthesis_Homo sapiens_hsa049180.60693229
103Bladder cancer_Homo sapiens_hsa052190.60430717
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57865929
105Fanconi anemia pathway_Homo sapiens_hsa034600.57824848
106Epstein-Barr virus infection_Homo sapiens_hsa051690.57202355
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57055700
108Renin-angiotensin system_Homo sapiens_hsa046140.55485266
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55440337
110Pathways in cancer_Homo sapiens_hsa052000.54481177
111Oocyte meiosis_Homo sapiens_hsa041140.52589370
112Hippo signaling pathway_Homo sapiens_hsa043900.52003726
113Tuberculosis_Homo sapiens_hsa051520.51832116
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51522235
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51183970
116Type I diabetes mellitus_Homo sapiens_hsa049400.51036239
117VEGF signaling pathway_Homo sapiens_hsa043700.50168191
118Notch signaling pathway_Homo sapiens_hsa043300.49764573
119Vitamin B6 metabolism_Homo sapiens_hsa007500.47698668
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.47684673
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47644687
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.44463088
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44345410
124Long-term depression_Homo sapiens_hsa047300.43722368
125Hedgehog signaling pathway_Homo sapiens_hsa043400.42971431
126Protein digestion and absorption_Homo sapiens_hsa049740.41541092
127GnRH signaling pathway_Homo sapiens_hsa049120.40618083

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