RANBP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.26311611
2synaptic vesicle exocytosis (GO:0016079)5.25830814
3establishment of mitochondrion localization (GO:0051654)5.22455592
4neuron cell-cell adhesion (GO:0007158)5.21839845
5mitochondrion transport along microtubule (GO:0047497)5.10381429
6establishment of mitochondrion localization, microtubule-mediated (GO:0034643)5.10381429
7vocalization behavior (GO:0071625)4.95159046
8mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.90234083
9positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.90234083
10regulation of synaptic vesicle exocytosis (GO:2000300)4.73731849
11synaptic vesicle maturation (GO:0016188)4.69693310
12glutamate secretion (GO:0014047)4.69004594
13protein localization to synapse (GO:0035418)4.47844263
14neurotransmitter secretion (GO:0007269)4.42944761
15locomotory exploration behavior (GO:0035641)4.37485080
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.36969700
17neurotransmitter-gated ion channel clustering (GO:0072578)4.36285756
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.35958775
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.32679462
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.31228900
21regulation of glutamate receptor signaling pathway (GO:1900449)4.24690506
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.09384045
23protein prenylation (GO:0018342)4.06439670
24prenylation (GO:0097354)4.06439670
25regulation of synaptic vesicle transport (GO:1902803)4.00983599
26DNA double-strand break processing (GO:0000729)3.99092743
27presynaptic membrane assembly (GO:0097105)3.86532968
28nuclear pore complex assembly (GO:0051292)3.82616486
29exploration behavior (GO:0035640)3.81196395
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.80110176
31cerebellar Purkinje cell differentiation (GO:0021702)3.79801036
32somatic diversification of immune receptors via somatic mutation (GO:0002566)3.75449792
33somatic hypermutation of immunoglobulin genes (GO:0016446)3.75449792
34neuron-neuron synaptic transmission (GO:0007270)3.74761896
35neuron recognition (GO:0008038)3.71881672
36gamma-aminobutyric acid transport (GO:0015812)3.70678776
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.64465615
38presynaptic membrane organization (GO:0097090)3.62411805
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.60803354
40neurotransmitter transport (GO:0006836)3.57597896
41layer formation in cerebral cortex (GO:0021819)3.57342624
42nuclear pore organization (GO:0006999)3.52745974
43pyrimidine nucleobase catabolic process (GO:0006208)3.52079715
44glutamate receptor signaling pathway (GO:0007215)3.50421213
45righting reflex (GO:0060013)3.49320624
46neural tube formation (GO:0001841)3.49243972
47synaptic transmission, glutamatergic (GO:0035249)3.48406584
48negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.41985764
49signal peptide processing (GO:0006465)3.38386004
50neuronal action potential propagation (GO:0019227)3.38336720
51mitotic sister chromatid cohesion (GO:0007064)3.38242075
52regulation of nuclear cell cycle DNA replication (GO:0033262)3.37892766
53axonal fasciculation (GO:0007413)3.37420386
54gamma-aminobutyric acid signaling pathway (GO:0007214)3.36508392
55monoubiquitinated protein deubiquitination (GO:0035520)3.36145979
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.35400668
57response to histamine (GO:0034776)3.35289048
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.32513309
59regulation of neuronal synaptic plasticity (GO:0048168)3.32337008
60olfactory bulb development (GO:0021772)3.32158135
61intraciliary transport (GO:0042073)3.27912489
62regulation of neurotransmitter levels (GO:0001505)3.27332316
63stress granule assembly (GO:0034063)3.25331454
64positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.23610129
65long-term synaptic potentiation (GO:0060291)3.23205236
66regulation of synapse structural plasticity (GO:0051823)3.22990611
67innervation (GO:0060384)3.22079790
68dendrite morphogenesis (GO:0048813)3.21830215
69postsynaptic membrane organization (GO:0001941)3.21686806
70histone-serine phosphorylation (GO:0035404)3.21627791
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.21200850
72synaptic vesicle endocytosis (GO:0048488)3.19267986
73mitochondrion distribution (GO:0048311)3.18996600
74startle response (GO:0001964)3.18403167
75regulation of chemokine-mediated signaling pathway (GO:0070099)3.17833210
76transmission of nerve impulse (GO:0019226)3.17781072
77behavioral response to cocaine (GO:0048148)3.13147897
78activation of protein kinase A activity (GO:0034199)3.12017010
79prepulse inhibition (GO:0060134)3.11689213
80regulation of long-term neuronal synaptic plasticity (GO:0048169)3.10720929
81regulation of neurotransmitter secretion (GO:0046928)3.10218756
82mitochondrion localization (GO:0051646)3.08230608
83limb bud formation (GO:0060174)3.08151415
84synapse assembly (GO:0007416)3.06141182
85regulation of excitatory postsynaptic membrane potential (GO:0060079)3.05141152
86cell migration in hindbrain (GO:0021535)3.04680468
87regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03140558
88negative regulation of DNA recombination (GO:0045910)3.01435326
89regulation of DNA endoreduplication (GO:0032875)3.00792010
90membrane depolarization during action potential (GO:0086010)3.00568415
91regulation of sarcomere organization (GO:0060297)2.98893430
92positive regulation of synaptic transmission, GABAergic (GO:0032230)2.98644512
93positive regulation of synapse assembly (GO:0051965)2.97989741
94regulation of vesicle fusion (GO:0031338)2.97457643
95regulation of postsynaptic membrane potential (GO:0060078)2.95999889
96pre-miRNA processing (GO:0031054)2.95796215
97proline transport (GO:0015824)2.94943603
98centriole replication (GO:0007099)2.94860696
99negative regulation of dendrite development (GO:2000171)2.94150379
100regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.93708951
101positive regulation of synapse maturation (GO:0090129)2.93382632
102positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.92850102
103cerebellar granule cell differentiation (GO:0021707)2.90111926
104regulation of neurotransmitter transport (GO:0051588)2.89526351
105negative regulation of activin receptor signaling pathway (GO:0032926)2.89043776
106dendrite development (GO:0016358)2.89024605
107striatum development (GO:0021756)2.89009834
108regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.88597283
109pore complex assembly (GO:0046931)2.87837372
110synapse organization (GO:0050808)2.87463296
111lipid particle organization (GO:0034389)2.87073782
112positive regulation of membrane potential (GO:0045838)2.86970362
113negative regulation of dendrite morphogenesis (GO:0050774)2.86644785
114regulation of synaptic transmission, GABAergic (GO:0032228)2.85803128
115forebrain neuron differentiation (GO:0021879)2.85787892
116calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.85696943
117G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.84755177
118myelin assembly (GO:0032288)2.84680000
119regulation of centriole replication (GO:0046599)2.84487644
120calcium ion-dependent exocytosis (GO:0017156)2.82769698
121negative regulation of neurotransmitter transport (GO:0051589)2.82428348
122regulation of synaptic plasticity (GO:0048167)2.81860065
123dendritic spine morphogenesis (GO:0060997)2.81816048
124mechanosensory behavior (GO:0007638)2.79739361
125peptidyl-arginine methylation (GO:0018216)2.79555924
126peptidyl-arginine N-methylation (GO:0035246)2.79555924
127membrane hyperpolarization (GO:0060081)2.78597078
128synaptic transmission (GO:0007268)2.77635546
129histone H2A acetylation (GO:0043968)2.76842083
130glial cell proliferation (GO:0014009)2.76417946
131nucleobase catabolic process (GO:0046113)2.76392036
132non-recombinational repair (GO:0000726)2.76028849
133double-strand break repair via nonhomologous end joining (GO:0006303)2.76028849
134positive regulation of neurotransmitter transport (GO:0051590)2.75740114
135membrane depolarization (GO:0051899)2.75630498
136central nervous system projection neuron axonogenesis (GO:0021952)2.75494211
137regulation of sister chromatid cohesion (GO:0007063)2.75290286
138DNA topological change (GO:0006265)2.74625500
139positive regulation of mitochondrial membrane permeability (GO:0035794)2.74292200
140positive regulation of dendritic spine morphogenesis (GO:0061003)2.73548967
141regulation of dendritic spine morphogenesis (GO:0061001)2.73415071
142social behavior (GO:0035176)2.71817840
143intraspecies interaction between organisms (GO:0051703)2.71817840
144negative regulation of sodium ion transport (GO:0010766)2.71342682
145establishment of synaptic vesicle localization (GO:0097480)2.70374470
146synaptic vesicle transport (GO:0048489)2.70374470
147establishment of nucleus localization (GO:0040023)2.69687285
148regulation of respiratory system process (GO:0044065)2.68467701
149cell differentiation in hindbrain (GO:0021533)2.68350591
150long-term memory (GO:0007616)2.68200685
151regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.67913722
152positive regulation of synaptic transmission (GO:0050806)2.67548556
153mitotic spindle organization (GO:0007052)2.64729827
154regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.62354696
155peptidyl-lysine trimethylation (GO:0018023)2.60225316
156organelle transport along microtubule (GO:0072384)2.58750411
157response to pheromone (GO:0019236)2.56906429
158microtubule anchoring (GO:0034453)2.56098563
159spindle checkpoint (GO:0031577)2.51826701
160mRNA splice site selection (GO:0006376)2.50397979
161regulation of spindle organization (GO:0090224)2.50386609
162ribonucleoprotein complex disassembly (GO:0032988)2.47705538
163negative regulation of fibroblast apoptotic process (GO:2000270)2.45768152
164reflex (GO:0060004)2.45764731
165regulation of centrosome cycle (GO:0046605)2.44490789
166DNA geometric change (GO:0032392)2.44483045
167negative regulation of microtubule depolymerization (GO:0007026)2.44191268
168regulation of transforming growth factor beta2 production (GO:0032909)2.43606846
169histone H4-K16 acetylation (GO:0043984)2.42684821
170histone H3-K9 methylation (GO:0051567)2.42404492
171mitotic spindle checkpoint (GO:0071174)2.42006012
172sister chromatid segregation (GO:0000819)2.41865376
173spliceosomal tri-snRNP complex assembly (GO:0000244)2.40302504
174regulation of microtubule depolymerization (GO:0031114)2.40271682
175positive regulation of developmental pigmentation (GO:0048087)2.39901205
176DNA duplex unwinding (GO:0032508)2.38183795
177regulation of telomere maintenance (GO:0032204)2.37711373
178centrosome localization (GO:0051642)2.37711000
179protein localization to microtubule cytoskeleton (GO:0072698)2.36013257
180DNA replication-dependent nucleosome assembly (GO:0006335)2.35796797
181DNA replication-dependent nucleosome organization (GO:0034723)2.35796797
182L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.35058019
183regulation of mRNA splicing, via spliceosome (GO:0048024)2.34848306
184central nervous system neuron axonogenesis (GO:0021955)2.34758382
185retinal ganglion cell axon guidance (GO:0031290)2.33432391

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.72428926
2GBX2_23144817_ChIP-Seq_PC3_Human4.02029918
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.13770170
4TAF15_26573619_Chip-Seq_HEK293_Human2.95699820
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67220589
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.65569237
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.48223932
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.46505965
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.41276141
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.30217420
11REST_21632747_ChIP-Seq_MESCs_Mouse2.27925338
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23934793
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17884534
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17884534
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.14533913
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13675711
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08469375
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08129769
19AR_21572438_ChIP-Seq_LNCaP_Human2.08118744
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05279365
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.03357890
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01484526
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00913510
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00652282
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96589819
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95429974
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94879295
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94628880
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92719672
30SMAD4_21799915_ChIP-Seq_A2780_Human1.92571325
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92421530
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.87555714
33P300_19829295_ChIP-Seq_ESCs_Human1.87477636
34DROSHA_22980978_ChIP-Seq_HELA_Human1.87423693
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85574959
36IGF1R_20145208_ChIP-Seq_DFB_Human1.85096809
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.84745580
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.84724211
39E2F7_22180533_ChIP-Seq_HELA_Human1.83532781
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.79352791
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78842558
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76149751
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.75301107
44ELK1_19687146_ChIP-ChIP_HELA_Human1.72957357
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.71880198
46* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71709311
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71019336
48ZNF274_21170338_ChIP-Seq_K562_Hela1.69796033
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68686872
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66483253
51* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65736249
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.63744478
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63573929
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.59796298
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59573107
56ER_23166858_ChIP-Seq_MCF-7_Human1.57240376
57FUS_26573619_Chip-Seq_HEK293_Human1.56287830
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.51434494
59* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49625997
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.49158034
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.48712533
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48410679
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48365405
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47207095
65STAT3_23295773_ChIP-Seq_U87_Human1.46751895
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46686324
67AR_25329375_ChIP-Seq_VCAP_Human1.46314191
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45902630
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45308599
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45073621
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.44755206
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43794049
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.42825362
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41505254
75VDR_22108803_ChIP-Seq_LS180_Human1.38090794
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38032573
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.35233485
78RNF2_27304074_Chip-Seq_NSC_Mouse1.34591403
79TCF4_23295773_ChIP-Seq_U87_Human1.31848726
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.29286234
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28939855
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.28915149
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.28135812
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26505814
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23317272
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.23012290
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.22991059
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22595200
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21952791
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21646832
91* VDR_23849224_ChIP-Seq_CD4+_Human1.20840105
92GABP_17652178_ChIP-ChIP_JURKAT_Human1.20323710
93EST1_17652178_ChIP-ChIP_JURKAT_Human1.18898420
94IRF1_19129219_ChIP-ChIP_H3396_Human1.18892289
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17682787
96ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17527863
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16902587
98AR_19668381_ChIP-Seq_PC3_Human1.16868912
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16603949
100RUNX2_22187159_ChIP-Seq_PCA_Human1.15421071
101* CIITA_25753668_ChIP-Seq_RAJI_Human1.15274975
102AHR_22903824_ChIP-Seq_MCF-7_Human1.14522069
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14494698
104BCAT_22108803_ChIP-Seq_LS180_Human1.14311776
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.13322124
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13152632
107PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12681258
108TP53_16413492_ChIP-PET_HCT116_Human1.12635098
109GATA1_26923725_Chip-Seq_HPCs_Mouse1.12228092
110SALL1_21062744_ChIP-ChIP_HESCs_Human1.11680079
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11501395
112YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10078926
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.09977468
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08134439
115CBP_20019798_ChIP-Seq_JUKART_Human1.07399040
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07399040
117CMYC_18555785_Chip-Seq_ESCs_Mouse1.07135173
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06486626
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06212597
120NANOG_18555785_Chip-Seq_ESCs_Mouse1.06063958
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05063360
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05063360
123KDM2B_26808549_Chip-Seq_REH_Human1.04291620
124STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04288854
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.04140663
126* SOX9_26525672_Chip-Seq_HEART_Mouse1.03606288
127TAL1_26923725_Chip-Seq_HPCs_Mouse1.03445971
128SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03262922
129RING1B_27294783_Chip-Seq_ESCs_Mouse1.03258310
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03208275
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02459902
132JUN_21703547_ChIP-Seq_K562_Human1.02138848
133* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02123340
134P53_22387025_ChIP-Seq_ESCs_Mouse1.02066795
135EWS_26573619_Chip-Seq_HEK293_Human1.02058030
136P300_18555785_Chip-Seq_ESCs_Mouse1.01133461
137PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00960430
138P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00842465
139LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00700085
140EP300_21415370_ChIP-Seq_HL-1_Mouse0.99728106
141PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99022724
142KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98404456
143VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98363943
144EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93803958
145TP53_18474530_ChIP-ChIP_U2OS_Human0.93759510
146WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92605329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.79314011
2MP0004859_abnormal_synaptic_plasticity4.68984868
3MP0003880_abnormal_central_pattern4.46791076
4MP0003635_abnormal_synaptic_transmissio3.58751625
5MP0004270_analgesia3.21459503
6MP0009745_abnormal_behavioral_response3.01126416
7MP0002063_abnormal_learning/memory/cond2.96957045
8MP0009046_muscle_twitch2.93645459
9MP0001968_abnormal_touch/_nociception2.89533113
10MP0002064_seizures2.81356540
11MP0008058_abnormal_DNA_repair2.61207156
12MP0005423_abnormal_somatic_nervous2.59838028
13MP0001984_abnormal_olfaction2.58002741
14MP0002572_abnormal_emotion/affect_behav2.55893229
15MP0006276_abnormal_autonomic_nervous2.54976533
16MP0001486_abnormal_startle_reflex2.54966079
17MP0003787_abnormal_imprinting2.53929397
18MP0002734_abnormal_mechanical_nocicepti2.50539650
19MP0002736_abnormal_nociception_after2.47631255
20MP0002272_abnormal_nervous_system2.44620667
21MP0002735_abnormal_chemical_nociception2.44280256
22MP0002102_abnormal_ear_morphology2.21386408
23MP0003122_maternal_imprinting2.19462275
24MP0000778_abnormal_nervous_system2.18123271
25MP0002822_catalepsy2.12847661
26MP0001529_abnormal_vocalization2.11192101
27MP0009780_abnormal_chondrocyte_physiolo2.03717282
28MP0002067_abnormal_sensory_capabilities2.03284845
29MP0002184_abnormal_innervation1.99320865
30MP0005551_abnormal_eye_electrophysiolog1.94591331
31MP0001440_abnormal_grooming_behavior1.93636151
32MP0010094_abnormal_chromosome_stability1.93009033
33MP0004133_heterotaxia1.92782741
34MP0005386_behavior/neurological_phenoty1.91321184
35MP0004924_abnormal_behavior1.91321184
36MP0003693_abnormal_embryo_hatching1.84717689
37MP0004811_abnormal_neuron_physiology1.81588805
38MP0005187_abnormal_penis_morphology1.79098218
39MP0002557_abnormal_social/conspecific_i1.77530099
40MP0002733_abnormal_thermal_nociception1.74427863
41MP0005646_abnormal_pituitary_gland1.74273285
42MP0008569_lethality_at_weaning1.71195408
43MP0003221_abnormal_cardiomyocyte_apopto1.67573261
44MP0001970_abnormal_pain_threshold1.66912164
45MP0003077_abnormal_cell_cycle1.63576575
46MP0001501_abnormal_sleep_pattern1.62885762
47MP0002909_abnormal_adrenal_gland1.58146181
48MP0005645_abnormal_hypothalamus_physiol1.57762159
49MP0000955_abnormal_spinal_cord1.56531833
50MP0002882_abnormal_neuron_morphology1.56380485
51MP0004084_abnormal_cardiac_muscle1.55768111
52MP0000516_abnormal_urinary_system1.45910311
53MP0005367_renal/urinary_system_phenotyp1.45910311
54MP0003656_abnormal_erythrocyte_physiolo1.43514390
55MP0002751_abnormal_autonomic_nervous1.40289028
56MP0003111_abnormal_nucleus_morphology1.39729571
57MP0003329_amyloid_beta_deposits1.36389366
58MP0000569_abnormal_digit_pigmentation1.35808745
59MP0002876_abnormal_thyroid_physiology1.35358413
60MP0001905_abnormal_dopamine_level1.34997547
61MP0003121_genomic_imprinting1.34398731
62MP0009703_decreased_birth_body1.31956940
63MP0002066_abnormal_motor_capabilities/c1.31111369
64MP0004858_abnormal_nervous_system1.29176765
65MP0001188_hyperpigmentation1.28874789
66MP0004885_abnormal_endolymph1.26880180
67MP0005394_taste/olfaction_phenotype1.24557396
68MP0005499_abnormal_olfactory_system1.24557396
69MP0008932_abnormal_embryonic_tissue1.22464274
70MP0002229_neurodegeneration1.21458073
71MP0004142_abnormal_muscle_tone1.19839434
72MP0005623_abnormal_meninges_morphology1.18229571
73MP0001502_abnormal_circadian_rhythm1.18185218
74MP0002152_abnormal_brain_morphology1.17962830
75MP0005248_abnormal_Harderian_gland1.17152752
76MP0006072_abnormal_retinal_apoptosis1.16077197
77MP0008775_abnormal_heart_ventricle1.15513325
78MP0002837_dystrophic_cardiac_calcinosis1.12370625
79MP0005253_abnormal_eye_physiology1.08807280
80MP0009697_abnormal_copulation1.07604840
81MP0001177_atelectasis1.07262460
82MP0003633_abnormal_nervous_system1.06928533
83MP0005266_abnormal_metabolism1.02550561
84MP0004233_abnormal_muscle_weight1.02268934
85MP0002752_abnormal_somatic_nervous1.01296787
86MP0003755_abnormal_palate_morphology1.00154492
87MP0004742_abnormal_vestibular_system1.00099780
88MP0000013_abnormal_adipose_tissue0.98417550
89MP0000383_abnormal_hair_follicle0.98223327
90MP0002938_white_spotting0.98223275
91MP0010352_gastrointestinal_tract_polyps0.97945092
92MP0002177_abnormal_outer_ear0.97791163
93MP0004197_abnormal_fetal_growth/weight/0.97184075
94MP0000751_myopathy0.97152156
95MP0000427_abnormal_hair_cycle0.94669070
96MP0003631_nervous_system_phenotype0.94577003
97MP0003634_abnormal_glial_cell0.92592141
98MP0004957_abnormal_blastocyst_morpholog0.91265508
99MP0003183_abnormal_peptide_metabolism0.90707547
100MP0005409_darkened_coat_color0.90358200
101MP0002233_abnormal_nose_morphology0.89124541
102MP0004085_abnormal_heartbeat0.88751315
103MP0004215_abnormal_myocardial_fiber0.88461076
104MP0002332_abnormal_exercise_endurance0.86876417
105MP0002069_abnormal_eating/drinking_beha0.86297955
106MP0006035_abnormal_mitochondrial_morpho0.86074735
107MP0001963_abnormal_hearing_physiology0.85515241
108MP0008789_abnormal_olfactory_epithelium0.84061366
109MP0002084_abnormal_developmental_patter0.83681404
110MP0003718_maternal_effect0.82869860
111MP0000631_abnormal_neuroendocrine_gland0.82602523
112MP0003385_abnormal_body_wall0.81824457
113MP0001346_abnormal_lacrimal_gland0.81140384
114MP0003786_premature_aging0.80628830
115MP0002638_abnormal_pupillary_reflex0.80615839
116MP0009053_abnormal_anal_canal0.78574111
117MP0003941_abnormal_skin_development0.77654909
118MP0000749_muscle_degeneration0.77469018
119MP0004036_abnormal_muscle_relaxation0.77410202
120MP0004484_altered_response_of0.77228234
121MP0000920_abnormal_myelination0.77026833
122MP0003935_abnormal_craniofacial_develop0.76565979
123MP0001286_abnormal_eye_development0.76378146
124MP0005195_abnormal_posterior_eye0.76068174
125MP0008872_abnormal_physiological_respon0.75808705
126MP0010678_abnormal_skin_adnexa0.75707410
127MP0004134_abnormal_chest_morphology0.75268514
128MP0001943_abnormal_respiration0.74476441
129MP0003890_abnormal_embryonic-extraembry0.74323350
130MP0008874_decreased_physiological_sensi0.74145077
131MP0001299_abnormal_eye_distance/0.74011552
132MP0003861_abnormal_nervous_system0.73993195
133MP0000647_abnormal_sebaceous_gland0.73963109
134MP0008877_abnormal_DNA_methylation0.73280125
135MP0000358_abnormal_cell_content/0.73099958
136MP0003632_abnormal_nervous_system0.71877463
137MP0003879_abnormal_hair_cell0.70365300
138MP0010386_abnormal_urinary_bladder0.67970842
139MP0005535_abnormal_body_temperature0.67863871
140MP0003690_abnormal_glial_cell0.66958072
141MP0002009_preneoplasia0.65579698
142MP0002090_abnormal_vision0.64637501
143MP0005410_abnormal_fertilization0.64310035
144MP0000537_abnormal_urethra_morphology0.64306049
145MP0001986_abnormal_taste_sensitivity0.63446420
146MP0005171_absent_coat_pigmentation0.63106992
147MP0002082_postnatal_lethality0.61021695
148MP0010770_preweaning_lethality0.61021695

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.15498903
2Myokymia (HP:0002411)4.82269497
3Focal seizures (HP:0007359)4.60870920
4Atonic seizures (HP:0010819)4.60596555
5Epileptic encephalopathy (HP:0200134)4.45847911
6Abnormality of the anterior horn cell (HP:0006802)4.40979062
7Degeneration of anterior horn cells (HP:0002398)4.40979062
8Febrile seizures (HP:0002373)4.33138702
9Abnormality of the labia minora (HP:0012880)4.25380394
10Progressive cerebellar ataxia (HP:0002073)3.83597939
11Hyperventilation (HP:0002883)3.73161883
12Absence seizures (HP:0002121)3.72201248
13Visual hallucinations (HP:0002367)3.69027082
14Pheochromocytoma (HP:0002666)3.60179048
15Impaired vibration sensation in the lower limbs (HP:0002166)3.56728744
16Volvulus (HP:0002580)3.52392861
17Neuroendocrine neoplasm (HP:0100634)3.41369374
18Termporal pattern (HP:0011008)3.33271132
19Insidious onset (HP:0003587)3.33271132
20Urinary bladder sphincter dysfunction (HP:0002839)3.26393086
21Dialeptic seizures (HP:0011146)3.20684679
22Urinary urgency (HP:0000012)3.15935405
23Long clavicles (HP:0000890)3.09721892
24Intestinal atresia (HP:0011100)3.08317326
25Abnormality of the corticospinal tract (HP:0002492)3.07253738
26Scanning speech (HP:0002168)3.04253370
27Truncal ataxia (HP:0002078)3.03661782
28Spastic gait (HP:0002064)2.99575677
29Generalized tonic-clonic seizures (HP:0002069)2.97975273
30Limb dystonia (HP:0002451)2.96154488
31Atrophy/Degeneration involving motor neurons (HP:0007373)2.92144287
32Broad-based gait (HP:0002136)2.88838170
33Dysdiadochokinesis (HP:0002075)2.84160791
34Gait imbalance (HP:0002141)2.81805631
35Gaze-evoked nystagmus (HP:0000640)2.79463413
36Action tremor (HP:0002345)2.78998306
37Cortical dysplasia (HP:0002539)2.78465529
38Ankle clonus (HP:0011448)2.77142805
39Fair hair (HP:0002286)2.75524155
40Upper motor neuron abnormality (HP:0002127)2.75412828
41Degeneration of the lateral corticospinal tracts (HP:0002314)2.70120558
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.70120558
43Short 1st metacarpal (HP:0010034)2.68798939
44Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.68798939
45Medulloblastoma (HP:0002885)2.67461300
46Drooling (HP:0002307)2.65680698
47Excessive salivation (HP:0003781)2.65680698
48Hypothermia (HP:0002045)2.65024653
49Central scotoma (HP:0000603)2.62769198
50Impaired social interactions (HP:0000735)2.59257552
51Abnormal social behavior (HP:0012433)2.59257552
52Abnormality of the metopic suture (HP:0005556)2.59041272
53Poor eye contact (HP:0000817)2.57548634
54Hepatoblastoma (HP:0002884)2.53461237
55Epileptiform EEG discharges (HP:0011182)2.50765918
56Abnormal hair whorl (HP:0010721)2.45152243
57Dysmetria (HP:0001310)2.44500996
58Congenital primary aphakia (HP:0007707)2.43398306
59Lower limb muscle weakness (HP:0007340)2.41395966
60Postural instability (HP:0002172)2.39748039
61Congenital stationary night blindness (HP:0007642)2.38941902
62Medial flaring of the eyebrow (HP:0010747)2.38906979
63EEG with generalized epileptiform discharges (HP:0011198)2.38348682
64Genital tract atresia (HP:0001827)2.37308954
65Blue irides (HP:0000635)2.34917711
66Hypsarrhythmia (HP:0002521)2.34298903
67Abnormal eating behavior (HP:0100738)2.32992846
68Amblyopia (HP:0000646)2.31396439
69Anxiety (HP:0000739)2.29560394
70Vaginal atresia (HP:0000148)2.29444372
71Nephrogenic diabetes insipidus (HP:0009806)2.28077212
72Impaired smooth pursuit (HP:0007772)2.27737062
73Exotropia (HP:0000577)2.26605415
74Supranuclear gaze palsy (HP:0000605)2.25454814
75Abnormality of the 1st metacarpal (HP:0010009)2.23626017
76Impaired vibratory sensation (HP:0002495)2.23567835
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.22691783
78Papillary thyroid carcinoma (HP:0002895)2.22565941
79Specific learning disability (HP:0001328)2.21289940
80Depression (HP:0000716)2.20729402
81Narrow forehead (HP:0000341)2.19688533
82Short tibia (HP:0005736)2.19387924
83Abnormality of the musculature of the pelvis (HP:0001469)2.19127651
84Abnormality of the hip-girdle musculature (HP:0001445)2.19127651
85Cystic hygroma (HP:0000476)2.18678391
86Abnormality of the lower motor neuron (HP:0002366)2.18534594
87Polyphagia (HP:0002591)2.17882852
88Protruding tongue (HP:0010808)2.17589288
89Absent speech (HP:0001344)2.17306250
90Neoplasm of the peripheral nervous system (HP:0100007)2.15423040
91Impaired proprioception (HP:0010831)2.14196227
92Vertebral arch anomaly (HP:0008438)2.12629190
93Aplasia/Hypoplasia of the brainstem (HP:0007362)2.12241013
94Hypoplasia of the brainstem (HP:0002365)2.12241013
95Genetic anticipation (HP:0003743)2.10891284
96Progressive inability to walk (HP:0002505)2.09868917
97Abnormality of ocular smooth pursuit (HP:0000617)2.08039643
98Abnormality of macular pigmentation (HP:0008002)2.07173410
99Neoplasm of the oral cavity (HP:0100649)2.05160806
100Conjunctival telangiectasia (HP:0000524)2.05032003
101Truncal obesity (HP:0001956)2.01943669
102Pancreatic fibrosis (HP:0100732)2.01773993
103Poor suck (HP:0002033)2.00257525
104Bony spicule pigmentary retinopathy (HP:0007737)1.99125550
105Facial hemangioma (HP:0000329)1.97820825
106Chronic hepatic failure (HP:0100626)1.97348894
107Torticollis (HP:0000473)1.97223119
108Intention tremor (HP:0002080)1.96881090
109Renal cortical cysts (HP:0000803)1.96057201
110Amyotrophic lateral sclerosis (HP:0007354)1.95659557
111Clonus (HP:0002169)1.95019462
112Oligodactyly (hands) (HP:0001180)1.94815524
113Postaxial hand polydactyly (HP:0001162)1.94157593
114Failure to thrive in infancy (HP:0001531)1.93746302
115Agitation (HP:0000713)1.93643155
116Aplasia/Hypoplasia of the sternum (HP:0006714)1.93257152
117Prominent metopic ridge (HP:0005487)1.91980524
118Gait ataxia (HP:0002066)1.91339919
119Focal dystonia (HP:0004373)1.89746748
120Abnormality of the astrocytes (HP:0100707)1.89439076
121Astrocytoma (HP:0009592)1.89439076
122Bradykinesia (HP:0002067)1.88714173
123Pelvic girdle muscle weakness (HP:0003749)1.88676048
124Molar tooth sign on MRI (HP:0002419)1.87628064
125Abnormality of midbrain morphology (HP:0002418)1.87628064
126Decreased lacrimation (HP:0000633)1.87180717
127Thyroid carcinoma (HP:0002890)1.87154544
128Abnormality of the antihelix (HP:0009738)1.87139711
129Shoulder girdle muscle weakness (HP:0003547)1.85762657
130Rhabdomyosarcoma (HP:0002859)1.84371541
131Impaired pain sensation (HP:0007328)1.80541191
132Abnormality of pain sensation (HP:0010832)1.80541191
133Generalized myoclonic seizures (HP:0002123)1.80032949
134Poor coordination (HP:0002370)1.79954241
135Rimmed vacuoles (HP:0003805)1.79711120
136Aplasia/Hypoplasia of the tongue (HP:0010295)1.78869313
137Morphological abnormality of the pyramidal tract (HP:0002062)1.78485002
138Heterotopia (HP:0002282)1.78191736
139Curly hair (HP:0002212)1.77897055
140Abnormality of saccadic eye movements (HP:0000570)1.77893800
141Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77684905
142Micropenis (HP:0000054)1.77647846
143Nephronophthisis (HP:0000090)1.77587653
144Fetal akinesia sequence (HP:0001989)1.77360435
145Hyperthyroidism (HP:0000836)1.77347619
146Dysmetric saccades (HP:0000641)1.76779799
147Large earlobe (HP:0009748)1.76116972
148Paraplegia (HP:0010550)1.75975190
149Spastic tetraplegia (HP:0002510)1.75653722
150Preaxial hand polydactyly (HP:0001177)1.75520759
151Ependymoma (HP:0002888)1.75480144
152Abnormality of salivation (HP:0100755)1.75337504
153Hypoventilation (HP:0002791)1.75202784
154Lissencephaly (HP:0001339)1.74480708
155Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71391151
156Oculomotor apraxia (HP:0000657)1.69710103
157True hermaphroditism (HP:0010459)1.68881457
158Pancreatic cysts (HP:0001737)1.67276617
159Abnormal lung lobation (HP:0002101)1.66057288
160Generalized hypopigmentation of hair (HP:0011358)1.65750666
161Submucous cleft hard palate (HP:0000176)1.65576318
162Alacrima (HP:0000522)1.65512095
163Short phalanx of the thumb (HP:0009660)1.65158880
164Hypoproteinemia (HP:0003075)1.64721927
165Megalencephaly (HP:0001355)1.64148695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.55731348
2CASK3.87228669
3MAP3K43.63851180
4NTRK33.59133237
5MARK13.55533336
6MAP3K123.24915797
7MAP2K73.21156356
8MINK12.45445922
9MAP3K92.41193748
10MAP2K42.32778864
11SRPK12.32588433
12CDK62.25898436
13EPHA42.22979386
14NTRK22.22632706
15PINK12.16402259
16MKNK22.06317083
17MAPK132.04108825
18EIF2AK32.00146328
19NEK91.94752516
20BRD41.77422681
21MKNK11.74246088
22EPHA31.73157818
23SGK21.69762780
24SGK2231.68998781
25SGK4941.68998781
26DAPK21.65176033
27SIK31.58053016
28UHMK11.48647862
29PLK21.44610668
30CDK51.43461018
31ERBB31.42619626
32SIK21.41596010
33AKT31.41003531
34PLK41.37185298
35PAK61.36118115
36STK38L1.35612679
37NEK11.31256952
38CCNB11.31134644
39BRSK21.31116134
40SGK31.29356317
41FGFR21.29282873
42PRKCG1.24212386
43KSR11.23618744
44PLK31.23260895
45TNIK1.21693908
46CSNK1G21.20984698
47DAPK11.16528312
48CAMK1D1.15332444
49TRIM281.13554499
50CAMK2A1.10894527
51OBSCN1.09108291
52BCR1.08814845
53GRK51.06557969
54CAMK2B1.06320191
55OXSR11.06240427
56PDK31.06149452
57PDK41.06149452
58PNCK1.01751910
59CDK191.01375325
60PRKD30.99033655
61NEK60.97188633
62CAMKK10.96466369
63PHKG20.93769025
64PHKG10.93769025
65FRK0.93198555
66WNK10.91144727
67PRKCH0.89904574
68PRPF4B0.88613644
69DYRK1A0.87682433
70SCYL20.86874823
71CDK180.86812059
72RET0.85861451
73YES10.84315596
74CSNK1G30.84071060
75NTRK10.83574928
76STK390.80974930
77CDK150.77520926
78CDK140.77485751
79PLK10.75780355
80PDK20.75623768
81WEE10.72919142
82SGK10.72617850
83PKN10.71194869
84WNK30.69200918
85PAK30.68921682
86FER0.68789371
87PRKCE0.68689247
88ATM0.68577606
89RPS6KA40.68189872
90PRKCZ0.65986702
91CHEK10.65178535
92VRK10.64554648
93RPS6KB10.64389454
94CDK40.62315553
95BUB10.62082686
96STK110.61334535
97CDK11A0.60776884
98CAMK2G0.60636119
99MARK20.60260786
100ATR0.59829307
101CAMK2D0.59502697
102BMPR1B0.58981669
103FES0.58415276
104PRKAA10.56810316
105EIF2AK10.56098311
106CAMKK20.55905245
107RPS6KA20.55124749
108LATS10.54736237
109ADRBK10.53847260
110CSNK1A1L0.53485887
111TSSK60.53394175
112CDK10.53031999
113RPS6KA30.52923189
114TYRO30.52733954
115CDC70.52687149
116NUAK10.52116612
117MAPK90.51843549
118STK380.50722483
119CSNK1G10.49200148
120KSR20.49110817
121FYN0.48940297
122PTK2B0.48451744
123LMTK20.48075012
124PRKCB0.47695169
125ZAK0.47394081
126ERBB40.47301389
127STK30.47264553
128PRKG10.47180801
129MAPK100.46524334
130CAMK1G0.46488069
131MAP3K20.46225004
132ROCK20.45943666
133MAP3K50.44832781
134CDK20.43236830
135PDK10.42127557
136FGFR10.42041488
137CHEK20.42016343
138GSK3B0.41341150
139LATS20.40878967
140ROCK10.40347884
141CSNK1D0.40197755
142TNK20.38713088
143PRKDC0.37631187
144NLK0.37567086
145ICK0.37327036
146PRKACB0.37237146
147CSNK1E0.36644760
148MAPK80.35135730
149DYRK20.35120400
150CAMK40.34365690
151ALK0.34075813
152BRSK10.32473421

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.97004122
2Nicotine addiction_Homo sapiens_hsa050333.74827802
3Synaptic vesicle cycle_Homo sapiens_hsa047213.52524399
4Protein export_Homo sapiens_hsa030603.24765424
5Basal transcription factors_Homo sapiens_hsa030222.80170545
6GABAergic synapse_Homo sapiens_hsa047272.78615782
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60307329
8Olfactory transduction_Homo sapiens_hsa047402.54506392
9Phototransduction_Homo sapiens_hsa047442.54063540
10Morphine addiction_Homo sapiens_hsa050322.41364550
11Circadian entrainment_Homo sapiens_hsa047132.37505008
12Dopaminergic synapse_Homo sapiens_hsa047282.24420233
13Long-term potentiation_Homo sapiens_hsa047202.21454468
14Glutamatergic synapse_Homo sapiens_hsa047242.20337085
15Amphetamine addiction_Homo sapiens_hsa050312.19194859
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14276513
17Cell cycle_Homo sapiens_hsa041102.13965916
18mRNA surveillance pathway_Homo sapiens_hsa030151.96969235
19Cholinergic synapse_Homo sapiens_hsa047251.81672989
20Collecting duct acid secretion_Homo sapiens_hsa049661.77622509
21Insulin secretion_Homo sapiens_hsa049111.76009926
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.74571672
23Serotonergic synapse_Homo sapiens_hsa047261.73426621
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73162610
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71278818
26Taste transduction_Homo sapiens_hsa047421.66900372
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65719318
28p53 signaling pathway_Homo sapiens_hsa041151.64812136
29Cocaine addiction_Homo sapiens_hsa050301.64044394
30Salivary secretion_Homo sapiens_hsa049701.59757989
31Renin secretion_Homo sapiens_hsa049241.57798245
32Long-term depression_Homo sapiens_hsa047301.57011970
33RNA transport_Homo sapiens_hsa030131.52729848
34Spliceosome_Homo sapiens_hsa030401.51777332
35Fanconi anemia pathway_Homo sapiens_hsa034601.47850899
36RNA degradation_Homo sapiens_hsa030181.46123689
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43111890
38Gastric acid secretion_Homo sapiens_hsa049711.40910956
39Steroid biosynthesis_Homo sapiens_hsa001001.39659676
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38651738
41Oxytocin signaling pathway_Homo sapiens_hsa049211.30521948
42Axon guidance_Homo sapiens_hsa043601.29068076
43Lysine degradation_Homo sapiens_hsa003101.27786441
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24474928
45Calcium signaling pathway_Homo sapiens_hsa040201.24001368
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19875959
47Vitamin B6 metabolism_Homo sapiens_hsa007501.19023439
48Gap junction_Homo sapiens_hsa045401.17980159
49Vibrio cholerae infection_Homo sapiens_hsa051101.16396484
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15593250
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15432620
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14106684
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11366959
54Regulation of autophagy_Homo sapiens_hsa041401.09061747
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05055619
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04643254
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04387172
58Type II diabetes mellitus_Homo sapiens_hsa049301.04203514
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03412078
60TGF-beta signaling pathway_Homo sapiens_hsa043501.03394026
61Butanoate metabolism_Homo sapiens_hsa006501.03234286
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02579006
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00151823
64GnRH signaling pathway_Homo sapiens_hsa049121.00113105
65cAMP signaling pathway_Homo sapiens_hsa040240.98572743
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.95373992
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94236786
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93367698
69Estrogen signaling pathway_Homo sapiens_hsa049150.91692984
70Glioma_Homo sapiens_hsa052140.90293841
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90139674
72ErbB signaling pathway_Homo sapiens_hsa040120.89977537
73Hippo signaling pathway_Homo sapiens_hsa043900.87013437
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86489115
75Mismatch repair_Homo sapiens_hsa034300.85186092
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83437579
77Glucagon signaling pathway_Homo sapiens_hsa049220.79899055
78Cardiac muscle contraction_Homo sapiens_hsa042600.79877776
79RNA polymerase_Homo sapiens_hsa030200.78023346
80MicroRNAs in cancer_Homo sapiens_hsa052060.77961516
81Hedgehog signaling pathway_Homo sapiens_hsa043400.77472610
82Alcoholism_Homo sapiens_hsa050340.77429415
83Nucleotide excision repair_Homo sapiens_hsa034200.76084533
84Dorso-ventral axis formation_Homo sapiens_hsa043200.75652578
85Melanogenesis_Homo sapiens_hsa049160.73291814
86FoxO signaling pathway_Homo sapiens_hsa040680.73263587
87Pyruvate metabolism_Homo sapiens_hsa006200.72137258
88Oocyte meiosis_Homo sapiens_hsa041140.69794439
89AMPK signaling pathway_Homo sapiens_hsa041520.69564158
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.67407271
91Thyroid hormone synthesis_Homo sapiens_hsa049180.67109803
92Base excision repair_Homo sapiens_hsa034100.65486070
93Prolactin signaling pathway_Homo sapiens_hsa049170.63837314
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63067537
95MAPK signaling pathway_Homo sapiens_hsa040100.62845543
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62517056
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58849557
98Propanoate metabolism_Homo sapiens_hsa006400.58068303
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56742840
100Alzheimers disease_Homo sapiens_hsa050100.55832345
101Type I diabetes mellitus_Homo sapiens_hsa049400.55562363
102Endometrial cancer_Homo sapiens_hsa052130.54103071
103Dilated cardiomyopathy_Homo sapiens_hsa054140.53931023
104Oxidative phosphorylation_Homo sapiens_hsa001900.53095207
105Choline metabolism in cancer_Homo sapiens_hsa052310.51846466
106Inositol phosphate metabolism_Homo sapiens_hsa005620.50464296
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49835715
108Parkinsons disease_Homo sapiens_hsa050120.48844437
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48141561
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45365298
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45284668
112Ras signaling pathway_Homo sapiens_hsa040140.44868592
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43622776
114Insulin signaling pathway_Homo sapiens_hsa049100.43342503
115Fatty acid biosynthesis_Homo sapiens_hsa000610.42888090
116Nitrogen metabolism_Homo sapiens_hsa009100.42382670
117Wnt signaling pathway_Homo sapiens_hsa043100.41928546
118Bile secretion_Homo sapiens_hsa049760.41779798
119Viral carcinogenesis_Homo sapiens_hsa052030.41011884
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.39986513
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39888951
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38332978
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38084277
124Arginine biosynthesis_Homo sapiens_hsa002200.37369813
125Pancreatic secretion_Homo sapiens_hsa049720.37328365
126Colorectal cancer_Homo sapiens_hsa052100.37184519
127Non-small cell lung cancer_Homo sapiens_hsa052230.36088081
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.35438766
129Endocytosis_Homo sapiens_hsa041440.34772695
130Purine metabolism_Homo sapiens_hsa002300.34607799
131Circadian rhythm_Homo sapiens_hsa047100.33910238
132Fatty acid metabolism_Homo sapiens_hsa012120.33780153
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32936239
134Renal cell carcinoma_Homo sapiens_hsa052110.32892933
135Carbon metabolism_Homo sapiens_hsa012000.32187096
136Systemic lupus erythematosus_Homo sapiens_hsa053220.31949084
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31929359
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31125958
139Selenocompound metabolism_Homo sapiens_hsa004500.30265606
140Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30165690
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29976133
142mTOR signaling pathway_Homo sapiens_hsa041500.29951777
143Ovarian steroidogenesis_Homo sapiens_hsa049130.28303680
144Rap1 signaling pathway_Homo sapiens_hsa040150.28006697

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