RANBP9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)7.06213882
2fusion of sperm to egg plasma membrane (GO:0007342)6.32755906
3male meiosis (GO:0007140)6.17366231
4cilium or flagellum-dependent cell motility (GO:0001539)5.98907068
5synaptonemal complex organization (GO:0070193)5.71190301
6sperm motility (GO:0030317)5.60557342
7synaptonemal complex assembly (GO:0007130)5.53352043
8acrosome assembly (GO:0001675)5.39342772
9nuclear pore organization (GO:0006999)5.34518719
10negative regulation of inclusion body assembly (GO:0090084)5.23457580
11multicellular organism reproduction (GO:0032504)5.14361867
12mitotic sister chromatid cohesion (GO:0007064)5.01978984
13plasma membrane fusion (GO:0045026)4.98791296
14monoubiquitinated protein deubiquitination (GO:0035520)4.96472411
15axonemal dynein complex assembly (GO:0070286)4.71685631
16reproduction (GO:0000003)4.43459126
17spermatid development (GO:0007286)4.38365266
18cytoplasmic mRNA processing body assembly (GO:0033962)4.37827953
19sperm-egg recognition (GO:0035036)4.37287521
20acrosome reaction (GO:0007340)4.36737536
21pore complex assembly (GO:0046931)4.35632770
22male meiosis I (GO:0007141)4.20224175
23cell wall macromolecule catabolic process (GO:0016998)4.12787025
24cell wall macromolecule metabolic process (GO:0044036)4.12787025
25cell-cell recognition (GO:0009988)4.08861714
26epithelial cilium movement (GO:0003351)4.03052599
27DNA methylation involved in gamete generation (GO:0043046)3.98945763
28regulation of clathrin-mediated endocytosis (GO:2000369)3.86414243
29binding of sperm to zona pellucida (GO:0007339)3.86037019
30regulation of histone H3-K27 methylation (GO:0061085)3.83780886
31protein targeting to Golgi (GO:0000042)3.78836684
32negative regulation of cell killing (GO:0031342)3.78798047
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.78798047
34motile cilium assembly (GO:0044458)3.75774580
35regulation of meiosis I (GO:0060631)3.74268110
36protein localization to endosome (GO:0036010)3.71992474
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.68667245
38gene silencing by RNA (GO:0031047)3.65789227
39cilium movement (GO:0003341)3.61461212
40definitive hemopoiesis (GO:0060216)3.55352047
41establishment of protein localization to Golgi (GO:0072600)3.54732988
42regulation of histone H3-K9 methylation (GO:0051570)3.54637771
43microtubule severing (GO:0051013)3.53554372
44clathrin coat assembly (GO:0048268)3.47538617
45retrograde transport, vesicle recycling within Golgi (GO:0000301)3.46146964
46meiotic nuclear division (GO:0007126)3.41957696
47meiotic cell cycle (GO:0051321)3.37747138
48meiosis I (GO:0007127)3.37595780
49NLS-bearing protein import into nucleus (GO:0006607)3.36318949
50regulation of RNA export from nucleus (GO:0046831)3.29417623
51COPII vesicle coating (GO:0048208)3.28975473
52spermatogenesis (GO:0007283)3.28839908
53fertilization (GO:0009566)3.28075375
54male gamete generation (GO:0048232)3.27467787
55negative regulation of histone methylation (GO:0031061)3.25768320
56single fertilization (GO:0007338)3.25386292
57gamete generation (GO:0007276)3.21656520
58chromosome organization involved in meiosis (GO:0070192)3.21037237
59negative regulation of potassium ion transmembrane transport (GO:1901380)3.19428818
60regulation of nucleobase-containing compound transport (GO:0032239)3.17808736
61vesicle coating (GO:0006901)3.17105800
62glucocorticoid receptor signaling pathway (GO:0042921)3.14218852
63histone H2B ubiquitination (GO:0033523)3.13712764
64negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.12551454
65histone lysine demethylation (GO:0070076)3.12301685
66regulation of inclusion body assembly (GO:0090083)3.09677936
67negative regulation of dendrite morphogenesis (GO:0050774)3.07816551
68regulation of establishment of cell polarity (GO:2000114)3.07716242
69regulation of early endosome to late endosome transport (GO:2000641)3.07664618
70chromosome condensation (GO:0030261)3.06678671
71regulation of histone methylation (GO:0031060)3.03114906
72histone demethylation (GO:0016577)3.02550968
73histone H3-K36 demethylation (GO:0070544)2.99771470
74sister chromatid cohesion (GO:0007062)2.99492283
75regulation of cilium movement (GO:0003352)2.99393514
76DNA packaging (GO:0006323)2.99035005
77cellular process involved in reproduction in multicellular organism (GO:0022412)2.97987866
78histone H3-K9 demethylation (GO:0033169)2.97601806
79negative regulation of erythrocyte differentiation (GO:0045647)2.96599375
80regulation of protein polyubiquitination (GO:1902914)2.96424106
81nuclear pore complex assembly (GO:0051292)2.96034869
82regulation of ARF protein signal transduction (GO:0032012)2.94757184
83Golgi to endosome transport (GO:0006895)2.91715154
84negative regulation of neurotransmitter secretion (GO:0046929)2.91454572
85positive regulation of protein export from nucleus (GO:0046827)2.90336890
86ventricular system development (GO:0021591)2.88941930
87peptidyl-threonine phosphorylation (GO:0018107)2.88914283
88cytoskeletal anchoring at plasma membrane (GO:0007016)2.85905369
89peptidyl-lysine dimethylation (GO:0018027)2.84819135
90peptidyl-threonine modification (GO:0018210)2.83540769
91regulation of sister chromatid cohesion (GO:0007063)2.83513780
92synapsis (GO:0007129)2.80471960
93regulation of cAMP-dependent protein kinase activity (GO:2000479)2.80004902
94negative regulation of DNA repair (GO:0045738)2.76601989
95germ cell development (GO:0007281)2.76457473
96calcium ion-dependent exocytosis (GO:0017156)2.75051186
97growth hormone receptor signaling pathway (GO:0060396)2.73869388
98regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.73643772
99nucleus organization (GO:0006997)2.73608683
100embryonic camera-type eye morphogenesis (GO:0048596)2.73012650
101regulation of histone H3-K4 methylation (GO:0051569)2.72587758
102iron ion import (GO:0097286)2.70092111
103seminiferous tubule development (GO:0072520)2.68367187
104protein export from nucleus (GO:0006611)2.67119141
105nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.66879056
106hypotonic response (GO:0006971)2.66802740
107DNA synthesis involved in DNA repair (GO:0000731)2.66158072
108RNA localization (GO:0006403)2.65506051
109N-terminal protein amino acid acetylation (GO:0006474)2.65130627
110interkinetic nuclear migration (GO:0022027)2.63160330
111genitalia morphogenesis (GO:0035112)2.61251183
112histone H3-K4 methylation (GO:0051568)2.59400382
113sperm capacitation (GO:0048240)2.58866161
114regulation of NFAT protein import into nucleus (GO:0051532)2.58836187
115protein localization to microtubule (GO:0035372)2.58788431
116multicellular organismal reproductive process (GO:0048609)2.57246402
117vesicle transport along microtubule (GO:0047496)2.56185431
118protein demethylation (GO:0006482)2.55909265
119protein dealkylation (GO:0008214)2.55909265
120regulation of response to osmotic stress (GO:0047484)2.54520210
121embryonic process involved in female pregnancy (GO:0060136)2.54041059
122gene silencing (GO:0016458)2.53770672
123positive regulation of mitotic sister chromatid separation (GO:1901970)2.51863534
124positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.51863534
125positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.51863534
126positive regulation of dendritic spine morphogenesis (GO:0061003)2.50347386
127histone H2A monoubiquitination (GO:0035518)2.49126639
128regulation of centriole replication (GO:0046599)2.49029859
129SMAD protein complex assembly (GO:0007183)2.48817202
130female gamete generation (GO:0007292)2.48671821
131cytoplasmic microtubule organization (GO:0031122)2.48651463
132negative regulation of histone modification (GO:0031057)2.48626419
133microtubule depolymerization (GO:0007019)2.47159521
134negative regulation of organelle assembly (GO:1902116)2.46054033
135nuclear envelope disassembly (GO:0051081)2.43706917
136membrane disassembly (GO:0030397)2.43706917
137positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.41639220
138regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.41639220
139mitotic chromosome condensation (GO:0007076)2.40137629
140meiotic cell cycle process (GO:1903046)2.39951678
141regulation of establishment or maintenance of cell polarity (GO:0032878)2.39866995
142histone H3-K4 trimethylation (GO:0080182)2.39840804
143positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.39770577
144embryonic eye morphogenesis (GO:0048048)2.39011433
145insulin-like growth factor receptor signaling pathway (GO:0048009)2.38725722
146protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.38650421
147negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.36313656
148corticosteroid receptor signaling pathway (GO:0031958)2.36199001
149positive regulation of histone methylation (GO:0031062)2.34301307
150cellular response to arsenic-containing substance (GO:0071243)2.34260213
151Golgi transport vesicle coating (GO:0048200)2.33965704
152COPI coating of Golgi vesicle (GO:0048205)2.33965704
153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.33927677
154regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.33927677
155heterochromatin organization (GO:0070828)2.33594101
156meiotic chromosome segregation (GO:0045132)2.33275118
157chondrocyte development (GO:0002063)2.32947119
158nerve growth factor signaling pathway (GO:0038180)2.32832410
159locomotory exploration behavior (GO:0035641)2.32751567
160cellular response to nerve growth factor stimulus (GO:1990090)2.32251812
161response to nerve growth factor (GO:1990089)2.32251812
162erythrocyte development (GO:0048821)2.29981984
163phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.29921358
164localization within membrane (GO:0051668)2.29902200
165stress granule assembly (GO:0034063)2.29192147
166receptor recycling (GO:0001881)2.28218016
167focal adhesion assembly (GO:0048041)2.26526858
168cell-substrate adherens junction assembly (GO:0007045)2.26526858
169regulation of DNA methylation (GO:0044030)2.26485038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.87010742
2E2F7_22180533_ChIP-Seq_HELA_Human3.45737406
3EZH2_22144423_ChIP-Seq_EOC_Human3.34276165
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.08586006
5WT1_19549856_ChIP-ChIP_CCG9911_Human2.95247364
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.72610413
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.54516000
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.53884693
9* PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.45927794
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29700174
11AR_21909140_ChIP-Seq_LNCAP_Human2.25688953
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20392623
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.08888694
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08269235
15WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.00145380
16* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.98243511
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98123745
18CLOCK_20551151_ChIP-Seq_293T_Human1.95727324
19DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.95209073
20* SMAD_19615063_ChIP-ChIP_OVARY_Human1.86167862
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80106987
22* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.76664758
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.76103106
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67989969
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63467268
26* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.62588215
27CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.59441211
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59236098
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54956808
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54930919
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.53900396
32SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.53849172
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51899995
34CTNNB1_20460455_ChIP-Seq_HCT116_Human1.51038991
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49352812
36GATA1_22025678_ChIP-Seq_K562_Human1.49251960
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48977576
38KDM2B_26808549_Chip-Seq_K562_Human1.47252516
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46838750
40* GATA2_19941826_ChIP-Seq_K562_Human1.46697808
41* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.45245344
42* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.44704145
43BRD4_25478319_ChIP-Seq_HGPS_Human1.42893727
44TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.42532220
45NFIB_24661679_ChIP-Seq_LUNG_Mouse1.41894719
46* GATA1_19941826_ChIP-Seq_K562_Human1.41223687
47P300_27058665_Chip-Seq_ZR-75-30cells_Human1.39582566
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.38614864
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.38454789
50BCAT_22108803_ChIP-Seq_LS180_Human1.36017878
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35723840
52NCOR1_26117541_ChIP-Seq_K562_Human1.34832792
53* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.34477077
54PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.33941738
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.33350240
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32874146
57MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32854625
58STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32007703
59TAF15_26573619_Chip-Seq_HEK293_Human1.31426936
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28785303
61SMAD4_21799915_ChIP-Seq_A2780_Human1.27469280
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26958910
63TCF7_22412390_ChIP-Seq_EML_Mouse1.26955007
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26883819
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26161034
66STAT3_23295773_ChIP-Seq_U87_Human1.25980575
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24701049
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.24660922
69STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.24318097
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23497318
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.23215820
72AHR_22903824_ChIP-Seq_MCF-7_Human1.21174972
73* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19592971
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19462611
75ZNF274_21170338_ChIP-Seq_K562_Hela1.18882619
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18497909
77* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18267472
78TP53_16413492_ChIP-PET_HCT116_Human1.18121273
79TBX20_22080862_ChIP-Seq_HEART_Mouse1.17108557
80TBX20_22328084_ChIP-Seq_HEART_Mouse1.17108557
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16292038
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.16268285
83CHD1_26751641_Chip-Seq_LNCaP_Human1.15632259
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15431956
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14609501
86ELK4_26923725_Chip-Seq_MESODERM_Mouse1.14325859
87* GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.13883180
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13807900
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13309804
90* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13245798
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.13211981
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12825527
93GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.12446720
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12046240
95FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11995287
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10743689
97TCF4_23295773_ChIP-Seq_U87_Human1.10707300
98EP300_21415370_ChIP-Seq_HL-1_Mouse1.10346473
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10334902
100* FUS_26573619_Chip-Seq_HEK293_Human1.09969135
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09433016
102SMRT_27268052_Chip-Seq_Bcells_Human1.07614044
103ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07328527
104TBL1_22424771_ChIP-Seq_293T_Human1.05427929
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05052801
106AR_25329375_ChIP-Seq_VCAP_Human1.03978414
107VDR_24787735_ChIP-Seq_THP-1_Human1.03930332
108CBP_20019798_ChIP-Seq_JUKART_Human1.03774714
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03774714
110WDR5_24793694_ChIP-Seq_LNCAP_Human1.03091975
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02546933
112RUNX_20019798_ChIP-Seq_JUKART_Human1.02391504
113GATA3_27048872_Chip-Seq_THYMUS_Human1.02286977
114* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01977088
115CDX2_22108803_ChIP-Seq_LS180_Human1.01277140
116FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01231991
117RARB_27405468_Chip-Seq_BRAIN_Mouse1.01203297
118* KDM2B_26808549_Chip-Seq_REH_Human1.01137354
119SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00892128
120SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00892128
121SCL_19346495_ChIP-Seq_HPC-7_Human0.99962675
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99845516
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99845516
124* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99717227
125EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99497548
126SMAD4_21741376_ChIP-Seq_EPCs_Human0.99181797
127GATA3_26560356_Chip-Seq_TH1_Human0.99117206
128RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99100651
129GF1_26923725_Chip-Seq_HPCs_Mouse0.99003623
130SMAD3_21741376_ChIP-Seq_ESCs_Human0.98623427
131KDM2B_26808549_Chip-Seq_JURKAT_Human0.98430212
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98299239
133CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98295382
134OCT1_27270436_Chip-Seq_PROSTATE_Human0.98268479
135AR_21572438_ChIP-Seq_LNCaP_Human0.98267620
136PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96799461
137TP63_23658742_ChIP-Seq_EP156T_Human0.96557536
138ESR2_21235772_ChIP-Seq_MCF-7_Human0.96098494
139NANOG_18555785_Chip-Seq_ESCs_Mouse0.95980140
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95270101
141ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95078700
142CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94618676
143GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93313195
144PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93002920
145NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92955933
146* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92189530
147KDM2B_26808549_Chip-Seq_DND41_Human0.91375630
148RUNX1_26923725_Chip-Seq_HPCs_Mouse0.90816303
149GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90506768
150SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89248497
151* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88872699
152TCF4_18268006_ChIP-ChIP_LS174T_Human0.88845929
153ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88750318
154IRF8_27001747_Chip-Seq_BMDM_Mouse0.88267591
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88045095
156PIAS1_25552417_ChIP-Seq_VCAP_Human0.87724725
157SMAD3_21741376_ChIP-Seq_EPCs_Human0.85373242
158PRDM14_20953172_ChIP-Seq_ESCs_Human0.85299107
159CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84901263
160ER_23166858_ChIP-Seq_MCF-7_Human0.84061769
161* FOXA2_19822575_ChIP-Seq_HepG2_Human0.83778962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.20043555
2MP0008877_abnormal_DNA_methylation4.29475057
3MP0008057_abnormal_DNA_replication3.29950272
4MP0001929_abnormal_gametogenesis3.24990582
5MP0004185_abnormal_adipocyte_glucose3.01022257
6MP0003698_abnormal_male_reproductive2.93435808
7MP0010234_abnormal_vibrissa_follicle2.85087841
8MP0005409_darkened_coat_color2.72431527
9MP0000569_abnormal_digit_pigmentation2.50889163
10MP0002653_abnormal_ependyma_morphology2.48074961
11MP0003303_peritoneal_inflammation2.47048284
12MP0003300_gastrointestinal_ulcer2.42056418
13MP0004859_abnormal_synaptic_plasticity2.39270939
14MP0002210_abnormal_sex_determination2.12954087
15MP0004084_abnormal_cardiac_muscle2.11432544
16MP0005275_abnormal_skin_tensile2.11182361
17MP0002796_impaired_skin_barrier2.08921071
18MP0003787_abnormal_imprinting2.03981379
19MP0005451_abnormal_body_composition1.97905363
20MP0008438_abnormal_cutaneous_collagen1.96831530
21MP0005076_abnormal_cell_differentiation1.95790924
22MP0002161_abnormal_fertility/fecundity1.92318790
23MP0003656_abnormal_erythrocyte_physiolo1.87632307
24MP0004270_analgesia1.86288789
25MP0003646_muscle_fatigue1.83799093
26MP0004510_myositis1.81804845
27MP0000653_abnormal_sex_gland1.74336279
28MP0001851_eye_inflammation1.73665854
29MP0004130_abnormal_muscle_cell1.73622703
30MP0003329_amyloid_beta_deposits1.68037939
31MP0001145_abnormal_male_reproductive1.66751106
32MP0005666_abnormal_adipose_tissue1.56823653
33MP0003705_abnormal_hypodermis_morpholog1.55897895
34MP0003566_abnormal_cell_adhesion1.54532224
35MP0002971_abnormal_brown_adipose1.53158843
36MP0000733_abnormal_muscle_development1.50620320
37MP0004808_abnormal_hematopoietic_stem1.44096322
38MP0005623_abnormal_meninges_morphology1.43934460
39MP0002877_abnormal_melanocyte_morpholog1.43766673
40MP0001348_abnormal_lacrimal_gland1.39697340
41MP0000759_abnormal_skeletal_muscle1.35612527
42MP0003950_abnormal_plasma_membrane1.35339404
43MP0000604_amyloidosis1.30432928
44MP0003091_abnormal_cell_migration1.29580770
45MP0004957_abnormal_blastocyst_morpholog1.28723792
46MP0003045_fibrosis1.26805570
47MP0002269_muscular_atrophy1.26664080
48MP0010307_abnormal_tumor_latency1.26530473
49MP0003385_abnormal_body_wall1.26125454
50MP0010630_abnormal_cardiac_muscle1.23909258
51MP0002060_abnormal_skin_morphology1.21318371
52MP0003635_abnormal_synaptic_transmissio1.21072691
53MP0008961_abnormal_basal_metabolism1.19812638
54MP0005375_adipose_tissue_phenotype1.19421234
55MP0005503_abnormal_tendon_morphology1.18880732
56MP0000350_abnormal_cell_proliferation1.14851086
57MP0010352_gastrointestinal_tract_polyps1.14644120
58MP0005501_abnormal_skin_physiology1.14171103
59MP0003828_pulmonary_edema1.13024625
60MP0005310_abnormal_salivary_gland1.12600293
61MP0010678_abnormal_skin_adnexa1.12125795
62MP0004233_abnormal_muscle_weight1.11647229
63MP0005380_embryogenesis_phenotype1.11434606
64MP0001672_abnormal_embryogenesis/_devel1.11434606
65MP0003123_paternal_imprinting1.11350874
66MP0005397_hematopoietic_system_phenotyp1.10401069
67MP0001545_abnormal_hematopoietic_system1.10401069
68MP0000427_abnormal_hair_cycle1.10038510
69MP0009703_decreased_birth_body1.09473851
70MP0004134_abnormal_chest_morphology1.08512245
71MP0003221_abnormal_cardiomyocyte_apopto1.05893486
72MP0005621_abnormal_cell_physiology1.05703471
73MP0006138_congestive_heart_failure1.05100441
74MP0002896_abnormal_bone_mineralization1.04303507
75MP0003984_embryonic_growth_retardation1.04114115
76MP0008995_early_reproductive_senescence1.03169034
77MP0004947_skin_inflammation1.02973520
78MP0002168_other_aberrant_phenotype1.02034738
79MP0002088_abnormal_embryonic_growth/wei1.01452805
80MP0004197_abnormal_fetal_growth/weight/0.99851461
81MP0002108_abnormal_muscle_morphology0.99428645
82MP0001730_embryonic_growth_arrest0.98865661
83MP0002080_prenatal_lethality0.97190632
84MP0003699_abnormal_female_reproductive0.96555446
85MP0002063_abnormal_learning/memory/cond0.96043820
86MP0009115_abnormal_fat_cell0.96041716
87MP0003690_abnormal_glial_cell0.95693483
88MP0000003_abnormal_adipose_tissue0.95292432
89MP0001849_ear_inflammation0.93628083
90MP0009278_abnormal_bone_marrow0.92713325
91MP0002006_tumorigenesis0.92336955
92MP0000377_abnormal_hair_follicle0.91737250
93MP0003077_abnormal_cell_cycle0.91469347
94MP0001501_abnormal_sleep_pattern0.91001734
95MP0001177_atelectasis0.88774906
96MP0002837_dystrophic_cardiac_calcinosis0.87652988
97MP0001299_abnormal_eye_distance/0.87425670
98MP0000749_muscle_degeneration0.87125995
99MP0010368_abnormal_lymphatic_system0.86667083
100MP0000462_abnormal_digestive_system0.86552671
101MP0000639_abnormal_adrenal_gland0.86157835
102MP0000920_abnormal_myelination0.85720016
103MP0000678_abnormal_parathyroid_gland0.85615784
104MP0002160_abnormal_reproductive_system0.83210611
105MP0003935_abnormal_craniofacial_develop0.82477442
106MP0000266_abnormal_heart_morphology0.82244460
107MP0002396_abnormal_hematopoietic_system0.82216933
108MP0003453_abnormal_keratinocyte_physiol0.79965879
109MP0001915_intracranial_hemorrhage0.79478183
110MP0003115_abnormal_respiratory_system0.77733357
111MP0003121_genomic_imprinting0.77657774
112MP0004885_abnormal_endolymph0.77504146
113MP0000015_abnormal_ear_pigmentation0.77443801
114MP0005167_abnormal_blood-brain_barrier0.77384514
115MP0003448_altered_tumor_morphology0.76849868
116MP0003632_abnormal_nervous_system0.76702536
117MP0003890_abnormal_embryonic-extraembry0.75580134
118MP0005384_cellular_phenotype0.75144362
119MP0002085_abnormal_embryonic_tissue0.73966686
120MP0004036_abnormal_muscle_relaxation0.73657564
121MP0002084_abnormal_developmental_patter0.72737151
122MP0003631_nervous_system_phenotype0.72342613
123MP0003633_abnormal_nervous_system0.71463036
124MP0003880_abnormal_central_pattern0.69424195
125MP0005408_hypopigmentation0.68501338
126MP0004087_abnormal_muscle_fiber0.67718681
127MP0009384_cardiac_valve_regurgitation0.66162487
128MP0009046_muscle_twitch0.65616426
129MP0005187_abnormal_penis_morphology0.65611910
130MP0000747_muscle_weakness0.63781270
131MP0001440_abnormal_grooming_behavior0.63533996
132MP0003763_abnormal_thymus_physiology0.62782526
133MP0005334_abnormal_fat_pad0.62585419
134MP0002166_altered_tumor_susceptibility0.61955962
135MP0004264_abnormal_extraembryonic_tissu0.61604588
136MP0002928_abnormal_bile_duct0.61480385
137MP0000579_abnormal_nail_morphology0.61250713
138MP0002009_preneoplasia0.60903410
139MP0002572_abnormal_emotion/affect_behav0.60096536
140MP0005647_abnormal_sex_gland0.59209029
141MP0002106_abnormal_muscle_physiology0.58827883
142MP0009780_abnormal_chondrocyte_physiolo0.57827378
143MP0001765_abnormal_ion_homeostasis0.57550095
144MP0005395_other_phenotype0.56734070
145MP0009672_abnormal_birth_weight0.56296882
146MP0001119_abnormal_female_reproductive0.56209281
147MP0002086_abnormal_extraembryonic_tissu0.55876312
148MP0001784_abnormal_fluid_regulation0.54883806
149MP0001697_abnormal_embryo_size0.53217580

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.46860914
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.56872945
3Absent/shortened dynein arms (HP:0200106)5.56872945
4Abnormal respiratory motile cilium physiology (HP:0012261)4.95941065
5Male infertility (HP:0003251)4.86548095
6Rhinitis (HP:0012384)4.85316548
7Chronic bronchitis (HP:0004469)4.76147985
8Infertility (HP:0000789)4.68505328
9Nasal polyposis (HP:0100582)4.03782959
10Abnormal respiratory epithelium morphology (HP:0012253)3.57451940
11Abnormal respiratory motile cilium morphology (HP:0005938)3.57451940
12Papillary thyroid carcinoma (HP:0002895)3.50207886
13Abnormality of the nasal mucosa (HP:0000433)3.37619997
14Ankyloglossia (HP:0010296)3.37221401
15Abnormal ciliary motility (HP:0012262)3.30332464
16Bronchiectasis (HP:0002110)2.99506627
17Subaortic stenosis (HP:0001682)2.97537970
18Abnormality of the left ventricular outflow tract (HP:0011103)2.97537970
19Bronchitis (HP:0012387)2.96234123
20Insidious onset (HP:0003587)2.80456330
21Termporal pattern (HP:0011008)2.80456330
22Relative macrocephaly (HP:0004482)2.76467305
23Hyperkalemia (HP:0002153)2.72959834
24Genetic anticipation (HP:0003743)2.65911123
25Abnormality of the lower motor neuron (HP:0002366)2.61189688
26Heterotopia (HP:0002282)2.60248957
27Disinhibition (HP:0000734)2.58928939
28Menstrual irregularities (HP:0000858)2.56523860
29Deep philtrum (HP:0002002)2.55724630
30Cerebral inclusion bodies (HP:0100314)2.54442836
31Microglossia (HP:0000171)2.48084670
32Abnormality of oral frenula (HP:0000190)2.43907174
33Neurofibrillary tangles (HP:0002185)2.38872491
34Protrusio acetabuli (HP:0003179)2.38584725
35Bowel incontinence (HP:0002607)2.38417033
36Curly hair (HP:0002212)2.37945849
37Amyotrophic lateral sclerosis (HP:0007354)2.35373573
38Volvulus (HP:0002580)2.34083764
39Acute myeloid leukemia (HP:0004808)2.31459688
40Hand muscle atrophy (HP:0009130)2.29710961
41Arterial tortuosity (HP:0005116)2.25322259
42Difficulty running (HP:0009046)2.23932480
43Vertebral arch anomaly (HP:0008438)2.22405221
44Upper limb muscle weakness (HP:0003484)2.21905989
45Overgrowth (HP:0001548)2.20848026
46Abnormal large intestine physiology (HP:0012700)2.17323177
47Autoamputation (HP:0001218)2.15410800
48Type 1 muscle fiber predominance (HP:0003803)2.10762820
49Decreased motor nerve conduction velocity (HP:0003431)2.10294034
50Impaired vibration sensation in the lower limbs (HP:0002166)2.10062962
51Increased nuchal translucency (HP:0010880)2.08836453
52Distal upper limb amyotrophy (HP:0007149)2.08424497
53Upper limb amyotrophy (HP:0009129)2.08424497
54Vascular tortuosity (HP:0004948)2.08166345
55Obsessive-compulsive behavior (HP:0000722)2.07226555
56Dysmetric saccades (HP:0000641)2.05941172
57Hammertoe (HP:0001765)2.05245513
58Nephronophthisis (HP:0000090)2.05066103
59Urinary bladder sphincter dysfunction (HP:0002839)2.04763984
60Facial hemangioma (HP:0000329)2.04111223
61Recurrent otitis media (HP:0000403)2.03907031
62Muscle fiber inclusion bodies (HP:0100299)2.03769692
63Thyroid carcinoma (HP:0002890)2.02159349
64Nemaline bodies (HP:0003798)2.01717465
65Cubitus valgus (HP:0002967)2.01585854
66Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.01511617
67Truncal obesity (HP:0001956)2.00648709
68Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.00333557
69Disproportionate tall stature (HP:0001519)2.00189820
70Lip pit (HP:0100267)1.99583840
71Macroorchidism (HP:0000053)1.98501532
72Action tremor (HP:0002345)1.97991522
73Visual hallucinations (HP:0002367)1.97421209
74Abnormality of ocular smooth pursuit (HP:0000617)1.97359991
75Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96901438
76Oligodactyly (hands) (HP:0001180)1.96250978
77Progressive cerebellar ataxia (HP:0002073)1.96022691
78Sandal gap (HP:0001852)1.95281994
79Bundle branch block (HP:0011710)1.95206413
80Supranuclear gaze palsy (HP:0000605)1.94775038
81Osteomalacia (HP:0002749)1.93901541
82Abnormality of the fingertips (HP:0001211)1.93101536
83Aortic aneurysm (HP:0004942)1.91791267
84Spontaneous abortion (HP:0005268)1.91095700
85Leiomyosarcoma (HP:0100243)1.90769895
86Uterine leiomyosarcoma (HP:0002891)1.90769895
87Distal lower limb amyotrophy (HP:0008944)1.89168655
88Cystic hygroma (HP:0000476)1.88618104
89Absent frontal sinuses (HP:0002688)1.87570246
90Inappropriate behavior (HP:0000719)1.86986716
91Mitral valve prolapse (HP:0001634)1.86602769
92Peripheral hypomyelination (HP:0007182)1.86496037
93Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.86213792
94Myocardial infarction (HP:0001658)1.85866229
95Papilledema (HP:0001085)1.85500871
96Asymmetric septal hypertrophy (HP:0001670)1.85085898
97Global brain atrophy (HP:0002283)1.84268251
98Slow saccadic eye movements (HP:0000514)1.84079369
99Sparse lateral eyebrow (HP:0005338)1.83705802
100Narrow palate (HP:0000189)1.83159298
101Impaired vibratory sensation (HP:0002495)1.83012970
102Conjunctival telangiectasia (HP:0000524)1.81871801
103Thickened helices (HP:0000391)1.81675838
104Intention tremor (HP:0002080)1.81603051
105Abnormality of skeletal muscle fiber size (HP:0012084)1.81415816
106Abnormality of nail color (HP:0100643)1.78956755
107Increased variability in muscle fiber diameter (HP:0003557)1.78412050
108Spinal rigidity (HP:0003306)1.78211521
109Subacute progressive viral hepatitis (HP:0006572)1.76800697
110Spondylolisthesis (HP:0003302)1.76515450
111Complete atrioventricular canal defect (HP:0001674)1.76406048
112Urinary urgency (HP:0000012)1.76321519
113Recurrent bronchitis (HP:0002837)1.76291547
114Distal lower limb muscle weakness (HP:0009053)1.76154709
115Abnormal spermatogenesis (HP:0008669)1.75391488
116Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.74121023
117Azoospermia (HP:0000027)1.74005543
118Insomnia (HP:0100785)1.73712388
119Atelectasis (HP:0100750)1.73147996
120Genu recurvatum (HP:0002816)1.72833568
121Abnormality of the musculature of the hand (HP:0001421)1.71761730
122Exercise-induced myalgia (HP:0003738)1.71295996
123Transitional cell carcinoma of the bladder (HP:0006740)1.70157754
124Abnormality of lateral ventricle (HP:0030047)1.69824190
125Degeneration of the lateral corticospinal tracts (HP:0002314)1.69729406
126Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69729406
127Lower limb amyotrophy (HP:0007210)1.69707066
128Dilatation of the ascending aorta (HP:0005111)1.69286266
129Dysmetria (HP:0001310)1.68825059
130Septate vagina (HP:0001153)1.67784008
131Abnormality of the corticospinal tract (HP:0002492)1.67142705
132Hypoplasia of the iris (HP:0007676)1.67037100
133Testicular neoplasm (HP:0010788)1.66811243
134Asymmetry of the thorax (HP:0001555)1.66791243
135Renovascular hypertension (HP:0100817)1.66406155
136Bladder neoplasm (HP:0009725)1.65901404
137Bladder carcinoma (HP:0002862)1.65901404
138Flat acetabular roof (HP:0003180)1.64924602
139Fatigue (HP:0012378)1.64847631
140Hyporeflexia of lower limbs (HP:0002600)1.64511870
141Ulnar deviation of the wrist (HP:0003049)1.63415006
142Premature rupture of membranes (HP:0001788)1.63182922
143Abnormality of the acetabulum (HP:0003170)1.62681896
144Coarse hair (HP:0002208)1.62433537
145Gaze-evoked nystagmus (HP:0000640)1.62177587
146Hematochezia (HP:0002573)1.61766921
147Atonic seizures (HP:0010819)1.60097724
148Widely spaced teeth (HP:0000687)1.59954761
149Neuronal loss in central nervous system (HP:0002529)1.59868631
150Increased connective tissue (HP:0009025)1.59247611
151Osteolytic defects of the phalanges of the hand (HP:0009771)1.59166553
152Osteolytic defects of the hand bones (HP:0009699)1.59166553
153Tubulointerstitial fibrosis (HP:0005576)1.59044694
154Germ cell neoplasia (HP:0100728)1.58797857
155Enlarged penis (HP:0000040)1.58193184
156Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.58020664
157Polycythemia (HP:0001901)1.57829730
158J-shaped sella turcica (HP:0002680)1.57609985
159Upper motor neuron abnormality (HP:0002127)1.56255139
160Recurrent sinusitis (HP:0011108)1.56171924
161Long toe (HP:0010511)1.55737176
162Gonadotropin excess (HP:0000837)1.54282527
163Cerebral aneurysm (HP:0004944)1.54146197
164Striae distensae (HP:0001065)1.53734104
165Focal seizures (HP:0007359)1.52428125
166Difficulty climbing stairs (HP:0003551)1.52402333
167Apathy (HP:0000741)1.52083094
168Focal motor seizures (HP:0011153)1.51020810
169Excessive salivation (HP:0003781)1.50693935
170Drooling (HP:0002307)1.50693935
171Abnormality of the renal medulla (HP:0100957)1.50420343
172Thyroiditis (HP:0100646)1.49278440
173Oligodactyly (HP:0012165)1.48351914

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD34.31352381
2PDK33.45888391
3PDK43.45888391
4MAP3K92.78669643
5LATS12.67670737
6BRD42.58437863
7MAP3K62.47016962
8KSR22.41213032
9AKT32.27715659
10LATS22.05441367
11TRIB31.98756003
12PNCK1.98463295
13MAP3K41.92037016
14PDK21.89949594
15TAOK11.87252952
16STK31.79185930
17PDGFRA1.68531398
18EIF2AK11.66139746
19STK381.64061178
20NEK21.63349937
21PAK61.61713762
22PRPF4B1.58411819
23DMPK1.57974477
24CAMK1G1.56240826
25NEK91.54747384
26PTK2B1.52764049
27TESK11.50171393
28ICK1.44158604
29MAP3K131.40568165
30CDC71.39233958
31MOS1.39023076
32TAOK31.38184134
33SCYL21.37096096
34YES11.36424225
35MAP2K41.36329235
36MET1.28749949
37CDK91.28410484
38BRAF1.25674089
39RIPK41.25188535
40MAP3K21.25027589
41NEK61.24091456
42PIK3CG1.22059817
43CDK121.21374837
44EPHB11.21145804
45RET1.20891513
46PDK11.18732454
47CLK11.16008210
48STK101.11540444
49STK391.09638002
50STK111.09328759
51SIK31.05622549
52FGFR31.05528357
53FGFR21.05244092
54MARK11.05059308
55CDK60.98908448
56TRPM70.96930978
57MAP2K10.93191492
58PKN20.93073038
59SGK30.90877409
60RAF10.90792280
61EIF2AK30.90792160
62PRKCH0.89950031
63PLK40.89648889
64WNK10.89557215
65EEF2K0.87310183
66PDPK10.85065202
67RPS6KB20.84606950
68STK240.84335973
69ERBB40.83139513
70CAMK1D0.81894284
71RIPK10.80997115
72SGK10.80327604
73KSR10.77564373
74CAMKK10.77560429
75STK38L0.77144847
76RPS6KB10.77044994
77JAK30.76030971
78BRSK10.75812763
79WEE10.75427976
80MELK0.75035137
81ITK0.71882819
82PLK20.69724937
83FRK0.69300544
84JAK10.69171443
85JAK20.68443292
86MAP3K70.68218349
87NTRK20.67754834
88PDGFRB0.67137855
89ARAF0.65233593
90SIK10.64689053
91SGK20.64298517
92CSNK1G20.62597833
93WNK40.61384525
94OBSCN0.61190660
95PRKD20.60750043
96BMPR20.59712541
97CHEK10.58519896
98CDK70.55501990
99RPS6KA40.54618850
100SIK20.53694889
101CDK10.51923769
102PAK20.51790605
103CDK20.49873619
104TYK20.49804837
105MINK10.49329693
106MARK20.48195911
107GSK3B0.48136331
108LRRK20.47992865
109CSNK1E0.47922981
110HIPK20.47695720
111CAMKK20.47339452
112CDK30.46378948
113MAPK100.45894092
114MAP4K10.45399097
115PTK20.45157651
116FGFR40.44987178
117MAP3K10.44830647
118ATM0.44733650
119MAP3K50.44673540
120MAP3K80.43578768
121EPHA30.43496944
122PRKCQ0.43315466
123MAPKAPK50.42603083
124ALK0.42502295
125FES0.40984582
126NLK0.40845547
127PRKAA10.40501925
128MAPK140.40233106
129CSNK1G10.40145215
130ZAP700.40084357
131SGK2230.38399693
132SGK4940.38399693
133MARK30.38361749
134ERBB30.37564473
135NTRK10.37558585
136TTK0.37555345
137MAP3K140.37327561
138NTRK30.36406332
139CSK0.35939150
140MAP2K70.35786007
141MTOR0.35166039
142TTN0.35004485
143RPS6KA30.34494912
144MAPK10.34285515
145BRSK20.34096211
146MAPK120.34095235
147PRKAA20.33810475
148ABL10.33666662

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043202.80283379
2Nitrogen metabolism_Homo sapiens_hsa009102.33317441
3Long-term potentiation_Homo sapiens_hsa047201.87931780
4Thyroid cancer_Homo sapiens_hsa052161.65454471
5Oocyte meiosis_Homo sapiens_hsa041141.65313388
6Acute myeloid leukemia_Homo sapiens_hsa052211.63319133
7Amphetamine addiction_Homo sapiens_hsa050311.52093735
8Pancreatic cancer_Homo sapiens_hsa052121.49864176
9Glucagon signaling pathway_Homo sapiens_hsa049221.47899408
10Renal cell carcinoma_Homo sapiens_hsa052111.46923554
11Estrogen signaling pathway_Homo sapiens_hsa049151.45795220
12VEGF signaling pathway_Homo sapiens_hsa043701.42960275
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42211434
14Renin secretion_Homo sapiens_hsa049241.41269533
15mRNA surveillance pathway_Homo sapiens_hsa030151.38921888
16Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37699396
17mTOR signaling pathway_Homo sapiens_hsa041501.35802845
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.35113632
19Glioma_Homo sapiens_hsa052141.33402744
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28761465
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22899236
22Cell cycle_Homo sapiens_hsa041101.19919426
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19633840
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18105536
25Dopaminergic synapse_Homo sapiens_hsa047281.16770907
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15696231
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.15674644
28Fatty acid biosynthesis_Homo sapiens_hsa000611.15434175
29GnRH signaling pathway_Homo sapiens_hsa049121.13458002
30Osteoclast differentiation_Homo sapiens_hsa043801.13403608
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13214871
32Circadian rhythm_Homo sapiens_hsa047101.11580927
33Oxytocin signaling pathway_Homo sapiens_hsa049211.11106854
34Vitamin B6 metabolism_Homo sapiens_hsa007501.10427769
35Long-term depression_Homo sapiens_hsa047301.07441086
36B cell receptor signaling pathway_Homo sapiens_hsa046621.06514541
37Adipocytokine signaling pathway_Homo sapiens_hsa049201.06185593
38T cell receptor signaling pathway_Homo sapiens_hsa046601.05712627
39Glutamatergic synapse_Homo sapiens_hsa047241.05418533
40Gastric acid secretion_Homo sapiens_hsa049711.05351895
41Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04574365
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03068870
43MAPK signaling pathway_Homo sapiens_hsa040101.02386883
44Cocaine addiction_Homo sapiens_hsa050301.02225986
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02140144
46Choline metabolism in cancer_Homo sapiens_hsa052311.01843374
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01398020
48Endocytosis_Homo sapiens_hsa041440.99960327
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.98502859
50Prolactin signaling pathway_Homo sapiens_hsa049170.97475531
51Non-small cell lung cancer_Homo sapiens_hsa052230.97354319
52Chronic myeloid leukemia_Homo sapiens_hsa052200.97262409
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96611433
54Salivary secretion_Homo sapiens_hsa049700.96323938
55AMPK signaling pathway_Homo sapiens_hsa041520.95161600
56cAMP signaling pathway_Homo sapiens_hsa040240.95094549
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95060481
58RNA transport_Homo sapiens_hsa030130.94545739
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93592700
60Insulin resistance_Homo sapiens_hsa049310.92552649
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.91744722
62Circadian entrainment_Homo sapiens_hsa047130.90482552
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89917915
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.89515242
65ErbB signaling pathway_Homo sapiens_hsa040120.87782402
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.87631149
67Amoebiasis_Homo sapiens_hsa051460.86687388
68FoxO signaling pathway_Homo sapiens_hsa040680.85989634
69Melanoma_Homo sapiens_hsa052180.85363343
70Platelet activation_Homo sapiens_hsa046110.84763577
71Cholinergic synapse_Homo sapiens_hsa047250.84652441
72Type II diabetes mellitus_Homo sapiens_hsa049300.81540644
73Small cell lung cancer_Homo sapiens_hsa052220.81458984
74Prion diseases_Homo sapiens_hsa050200.81274213
75Inositol phosphate metabolism_Homo sapiens_hsa005620.80726189
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80590505
77Ovarian steroidogenesis_Homo sapiens_hsa049130.80163208
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79034701
79Colorectal cancer_Homo sapiens_hsa052100.78379823
80HIF-1 signaling pathway_Homo sapiens_hsa040660.78253856
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.77699921
82Bladder cancer_Homo sapiens_hsa052190.77392980
83Chemokine signaling pathway_Homo sapiens_hsa040620.76588404
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75696000
85TGF-beta signaling pathway_Homo sapiens_hsa043500.75369977
86Toxoplasmosis_Homo sapiens_hsa051450.74388331
87Wnt signaling pathway_Homo sapiens_hsa043100.73631004
88Prostate cancer_Homo sapiens_hsa052150.72844113
89Adherens junction_Homo sapiens_hsa045200.72596200
90Synaptic vesicle cycle_Homo sapiens_hsa047210.72505360
91Olfactory transduction_Homo sapiens_hsa047400.72427952
92Viral carcinogenesis_Homo sapiens_hsa052030.72219572
93Shigellosis_Homo sapiens_hsa051310.72009864
94Insulin signaling pathway_Homo sapiens_hsa049100.72004958
95Endometrial cancer_Homo sapiens_hsa052130.71507254
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69973468
97Thyroid hormone synthesis_Homo sapiens_hsa049180.68703203
98Proteoglycans in cancer_Homo sapiens_hsa052050.68099437
99Dilated cardiomyopathy_Homo sapiens_hsa054140.68032595
100Insulin secretion_Homo sapiens_hsa049110.67412418
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65822886
102Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65583490
103Melanogenesis_Homo sapiens_hsa049160.65401849
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.64037972
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63995399
106Gap junction_Homo sapiens_hsa045400.63902825
107Ras signaling pathway_Homo sapiens_hsa040140.63457647
108MicroRNAs in cancer_Homo sapiens_hsa052060.62746074
109ECM-receptor interaction_Homo sapiens_hsa045120.62556586
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62014528
111Morphine addiction_Homo sapiens_hsa050320.59066565
112Salmonella infection_Homo sapiens_hsa051320.58723231
113PPAR signaling pathway_Homo sapiens_hsa033200.57765245
114Lysine degradation_Homo sapiens_hsa003100.57702302
115Hepatitis B_Homo sapiens_hsa051610.57401417
116Rap1 signaling pathway_Homo sapiens_hsa040150.57263708
117Glycerolipid metabolism_Homo sapiens_hsa005610.56187782
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55938706
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55900762
120Ether lipid metabolism_Homo sapiens_hsa005650.55715215
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55633135
122TNF signaling pathway_Homo sapiens_hsa046680.55091258
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53270832
124Focal adhesion_Homo sapiens_hsa045100.53172887
125Hippo signaling pathway_Homo sapiens_hsa043900.53137866
126Pathways in cancer_Homo sapiens_hsa052000.51168522
127Hepatitis C_Homo sapiens_hsa051600.50838434
128Tight junction_Homo sapiens_hsa045300.50008179

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