RANGAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.63241488
2peptidyl-arginine omega-N-methylation (GO:0035247)4.45077369
3Golgi transport vesicle coating (GO:0048200)4.36901209
4COPI coating of Golgi vesicle (GO:0048205)4.36901209
5mitotic sister chromatid segregation (GO:0000070)4.31228206
6regulation of translational termination (GO:0006449)4.27321469
7regulation of mammary gland epithelial cell proliferation (GO:0033599)4.26956783
8protein localization to kinetochore (GO:0034501)4.12681855
9cytoskeletal anchoring at plasma membrane (GO:0007016)4.11052379
10sister chromatid segregation (GO:0000819)4.07410144
11negative regulation of microtubule polymerization (GO:0031115)4.02043167
12peptidyl-arginine methylation (GO:0018216)3.90611991
13peptidyl-arginine N-methylation (GO:0035246)3.90611991
14DNA packaging (GO:0006323)3.89383282
15protein localization to endosome (GO:0036010)3.88503652
16activation of Rac GTPase activity (GO:0032863)3.88474472
17adherens junction assembly (GO:0034333)3.86454803
18histone arginine methylation (GO:0034969)3.83618034
19folic acid-containing compound biosynthetic process (GO:0009396)3.82880312
20regulation of translational fidelity (GO:0006450)3.76836523
21proline biosynthetic process (GO:0006561)3.76479917
22regulation of short-term neuronal synaptic plasticity (GO:0048172)3.75254072
23protein retention in ER lumen (GO:0006621)3.75169020
24focal adhesion assembly (GO:0048041)3.73505626
25cell-substrate adherens junction assembly (GO:0007045)3.73505626
26regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.73408381
27pre-miRNA processing (GO:0031054)3.71466905
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.67424982
29protein localization to chromosome, centromeric region (GO:0071459)3.61779990
30synaptic vesicle maturation (GO:0016188)3.61169386
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.58434069
32retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.56972416
33cellular protein complex localization (GO:0034629)3.51942593
34planar cell polarity pathway involved in neural tube closure (GO:0090179)3.47878728
35cell-substrate junction assembly (GO:0007044)3.45490833
36positive regulation of synapse maturation (GO:0090129)3.39928239
37layer formation in cerebral cortex (GO:0021819)3.37209290
38hemidesmosome assembly (GO:0031581)3.36014150
39nuclear pore organization (GO:0006999)3.35058239
40negative regulation of cell size (GO:0045792)3.33483564
41DNA replication-dependent nucleosome organization (GO:0034723)3.31435331
42DNA replication-dependent nucleosome assembly (GO:0006335)3.31435331
43mitotic nuclear envelope disassembly (GO:0007077)3.30620691
44nuclear envelope disassembly (GO:0051081)3.28645597
45membrane disassembly (GO:0030397)3.28645597
46regulation of early endosome to late endosome transport (GO:2000641)3.23653802
47spliceosomal tri-snRNP complex assembly (GO:0000244)3.22106864
48nuclear pore complex assembly (GO:0051292)3.20946866
49protein-DNA complex disassembly (GO:0032986)3.18243802
50nucleosome disassembly (GO:0006337)3.18243802
51apoptotic process involved in morphogenesis (GO:0060561)3.16439890
52heterochromatin organization (GO:0070828)3.14724318
53glutamate secretion (GO:0014047)3.13746683
54mitotic G1/S transition checkpoint (GO:0044819)3.13657854
55G1 DNA damage checkpoint (GO:0044783)3.11830861
56regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.09986140
57chaperone-mediated protein complex assembly (GO:0051131)3.09935999
58protein maturation by protein folding (GO:0022417)3.05861857
59synaptic vesicle exocytosis (GO:0016079)3.02133644
60pore complex assembly (GO:0046931)3.01592145
61nuclear envelope reassembly (GO:0031468)3.00089735
62mitotic nuclear envelope reassembly (GO:0007084)3.00089735
63formation of translation preinitiation complex (GO:0001731)2.97984739
64positive regulation of chromosome segregation (GO:0051984)2.96320552
65DNA replication initiation (GO:0006270)2.91831535
66mitotic metaphase plate congression (GO:0007080)2.91574340
67cell migration in hindbrain (GO:0021535)2.89596159
68establishment of apical/basal cell polarity (GO:0035089)2.89041525
69cerebellar Purkinje cell layer development (GO:0021680)2.89032604
70DNA conformation change (GO:0071103)2.88247155
71glucocorticoid receptor signaling pathway (GO:0042921)2.88235579
72regulation of NFAT protein import into nucleus (GO:0051532)2.85536751
73intracellular estrogen receptor signaling pathway (GO:0030520)2.85112266
74IMP biosynthetic process (GO:0006188)2.84769254
75DNA strand elongation involved in DNA replication (GO:0006271)2.84399798
76protein complex localization (GO:0031503)2.83852668
77maturation of SSU-rRNA (GO:0030490)2.81533823
78negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.81508298
79protein export from nucleus (GO:0006611)2.81174214
80nucleobase biosynthetic process (GO:0046112)2.79601184
81regulation of synaptic vesicle exocytosis (GO:2000300)2.78103100
82DNA duplex unwinding (GO:0032508)2.77051896
83DNA geometric change (GO:0032392)2.74871604
84mitotic chromosome condensation (GO:0007076)2.74839365
85regulation of posttranscriptional gene silencing (GO:0060147)2.73006244
86regulation of gene silencing by miRNA (GO:0060964)2.73006244
87regulation of gene silencing by RNA (GO:0060966)2.73006244
88regulation of chromosome segregation (GO:0051983)2.72257794
89regulation of translational elongation (GO:0006448)2.70426516
90maternal placenta development (GO:0001893)2.68328930
91locomotory exploration behavior (GO:0035641)2.68124598
92regulation of spindle organization (GO:0090224)2.67892336
93mitotic spindle organization (GO:0007052)2.67678145
94microtubule depolymerization (GO:0007019)2.64119045
95nucleobase-containing small molecule interconversion (GO:0015949)2.63842950
96regulation of histone H3-K27 methylation (GO:0061085)2.62434855
97protein localization to chromosome (GO:0034502)2.62209085
98establishment of protein localization to mitochondrial membrane (GO:0090151)2.62164900
99DNA strand elongation (GO:0022616)2.60361012
100activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.60341898
101synaptic vesicle docking involved in exocytosis (GO:0016081)2.60041279
102negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.59412833
103nuclear envelope organization (GO:0006998)2.59399152
104positive regulation of nuclease activity (GO:0032075)2.59085426
105sodium ion export (GO:0071436)2.58525472
106regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.58134778
107positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.58134778
108negative regulation of chromosome segregation (GO:0051985)2.56003694
109positive regulation of DNA-dependent DNA replication (GO:2000105)2.56002681
110negative regulation of histone methylation (GO:0031061)2.55937411
111regulation of centrosome cycle (GO:0046605)2.55580305
112semaphorin-plexin signaling pathway (GO:0071526)2.54183327
113regulation of nucleobase-containing compound transport (GO:0032239)2.53988339
114peptidyl-lysine dimethylation (GO:0018027)2.53330429
115desmosome organization (GO:0002934)2.52524262
116neurotransmitter secretion (GO:0007269)2.51970470
117positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.51048769
118positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.51048769
119positive regulation of mitotic sister chromatid separation (GO:1901970)2.51048769
120chromosome condensation (GO:0030261)2.50094689
121basement membrane organization (GO:0071711)2.49486929
122rRNA transcription (GO:0009303)2.46362273
123metaphase plate congression (GO:0051310)2.46169108
124regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.46095903
125vocalization behavior (GO:0071625)2.44123953
126negative regulation of mitotic sister chromatid separation (GO:2000816)2.43984167
127negative regulation of mitotic sister chromatid segregation (GO:0033048)2.43984167
128negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.43984167
129negative regulation of sister chromatid segregation (GO:0033046)2.43984167
130cellular response to epidermal growth factor stimulus (GO:0071364)2.43856946
131proline metabolic process (GO:0006560)2.43496027
132mitotic spindle assembly checkpoint (GO:0007094)2.43213663
133regulation of mitotic spindle organization (GO:0060236)2.43101707
134epithelial cell-cell adhesion (GO:0090136)2.42960519
135ribosome biogenesis (GO:0042254)2.42700234
136establishment of chromosome localization (GO:0051303)2.42428120
137spindle assembly checkpoint (GO:0071173)2.42168169
138spindle checkpoint (GO:0031577)2.42039112
139dendritic spine morphogenesis (GO:0060997)2.41737020
140convergent extension (GO:0060026)2.41626320
141protein localization to synapse (GO:0035418)2.41253152
142stress fiber assembly (GO:0043149)2.41002834
143mitotic G1 DNA damage checkpoint (GO:0031571)2.40931879
144protein targeting to plasma membrane (GO:0072661)2.40896670
145mitotic spindle checkpoint (GO:0071174)2.40154084
146regulation of RNA export from nucleus (GO:0046831)2.38428200
147positive regulation of protein dephosphorylation (GO:0035307)2.38329255
148regulation of glucose import in response to insulin stimulus (GO:2001273)2.38320237
149negative regulation of organelle assembly (GO:1902116)2.37249236
150negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.34699041
151regulation of sister chromatid segregation (GO:0033045)2.34066012
152regulation of mitotic sister chromatid separation (GO:0010965)2.34066012
153regulation of mitotic sister chromatid segregation (GO:0033047)2.34066012
154tRNA aminoacylation for protein translation (GO:0006418)2.33809804
155negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.33781354
156spliceosomal snRNP assembly (GO:0000387)2.33637786
157spindle assembly involved in mitosis (GO:0090307)2.33384220
158regulation of sister chromatid cohesion (GO:0007063)2.32331210
159regulation of mitotic metaphase/anaphase transition (GO:0030071)2.31865007
160establishment of integrated proviral latency (GO:0075713)2.31799393
161positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.31633569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.08831490
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.47918865
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.53892380
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51841082
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10295343
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.05884536
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.97959153
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.90349766
9* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52700721
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.46761436
11XRN2_22483619_ChIP-Seq_HELA_Human2.28332409
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.26650267
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25975631
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.24921600
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19160080
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15151007
17* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14331837
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.13095003
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.02026622
20MYC_22102868_ChIP-Seq_BL_Human2.00664286
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.00382592
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95771291
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.94430044
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.94366956
25* RACK7_27058665_Chip-Seq_MCF-7_Human1.93072414
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.92941369
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92241459
28EZH2_22144423_ChIP-Seq_EOC_Human1.90991995
29* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90526408
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88864246
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.87895105
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.87451881
33* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.84365731
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83202489
35AR_21909140_ChIP-Seq_LNCAP_Human1.76960082
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.76818251
37* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75413382
38ZNF263_19887448_ChIP-Seq_K562_Human1.75169631
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71392053
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65074337
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.64249281
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62669365
43TTF2_22483619_ChIP-Seq_HELA_Human1.62591327
44TCF7_22412390_ChIP-Seq_EML_Mouse1.62448408
45* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.61825913
46KDM2B_26808549_Chip-Seq_K562_Human1.60187106
47P68_20966046_ChIP-Seq_HELA_Human1.60059266
48* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.58008874
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56506993
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55316867
51* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.50151110
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49887193
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48414945
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.47885644
55* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47880394
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.47847555
57* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47741597
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46839991
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46700674
60* EST1_17652178_ChIP-ChIP_JURKAT_Human1.46105007
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45577763
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43484777
63RARB_27405468_Chip-Seq_BRAIN_Mouse1.42658814
64* ATF3_27146783_Chip-Seq_COLON_Human1.41198237
65SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.41052153
66* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40895716
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40718650
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39876933
69* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39793614
70* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39756942
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39455743
72CIITA_25753668_ChIP-Seq_RAJI_Human1.38875536
73GABP_19822575_ChIP-Seq_HepG2_Human1.37819468
74SMC4_20622854_ChIP-Seq_HELA_Human1.37606027
75SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35356719
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34321410
77KDM5A_27292631_Chip-Seq_BREAST_Human1.34154457
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.33753906
79* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32601028
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.31795263
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29854254
82* TP53_22127205_ChIP-Seq_IMR90_Human1.29287385
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28866498
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27923770
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26102151
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25143398
87DCP1A_22483619_ChIP-Seq_HELA_Human1.24905469
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24542958
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24317413
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23904339
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23825221
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23669915
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22845968
94CREB1_26743006_Chip-Seq_LNCaP_Human1.22172470
95* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22116277
96SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22097428
97NANOG_21062744_ChIP-ChIP_HESCs_Human1.21785342
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.20959598
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20803777
100* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20803276
101REST_18959480_ChIP-ChIP_MESCs_Mouse1.20013362
102NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17738030
103REST_21632747_ChIP-Seq_MESCs_Mouse1.17227291
104ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16731189
105CLOCK_20551151_ChIP-Seq_293T_Human1.12727111
106* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11838750
107STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11139619
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10337986
109GABP_17652178_ChIP-ChIP_JURKAT_Human1.10155585
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09179407
111UBF1/2_26484160_Chip-Seq_HMECs_Human1.08569821
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08495762
113FOXP1_21924763_ChIP-Seq_HESCs_Human1.06372935
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05149491
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04372685
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04342653
117* RARA_24833708_ChIP-Seq_LIVER_Mouse1.04261296
118SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04040321
119TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03709155
120RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03623563
121* FOXP3_21729870_ChIP-Seq_TREG_Human1.03432402
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03107911
123* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03036399
124CTCF_27219007_Chip-Seq_Bcells_Human1.02716861
125OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02611216
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02347047
127TET1_21490601_ChIP-Seq_MESCs_Mouse1.01970271
128SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00882320
129TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00602768
130NCOR1_26117541_ChIP-Seq_K562_Human1.00449565
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00177180
132* VDR_23849224_ChIP-Seq_CD4+_Human0.99850194
133BCOR_27268052_Chip-Seq_Bcells_Human0.98838356
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98579366
135VDR_21846776_ChIP-Seq_THP-1_Human0.98573368
136NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98334973
137ESR2_21235772_ChIP-Seq_MCF-7_Human0.98299127
138EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98088276
139STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98056845
140SALL1_21062744_ChIP-ChIP_HESCs_Human0.97817151
141SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97284255
142MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96331825
143LXR_22292898_ChIP-Seq_THP-1_Human0.95982867
144TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95612690
145ERG_21242973_ChIP-ChIP_JURKAT_Human0.95124938
146MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94700674
147MAF_26560356_Chip-Seq_TH2_Human0.94500814
148KDM2B_26808549_Chip-Seq_DND41_Human0.94257083
149SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94220149
150ZNF274_21170338_ChIP-Seq_K562_Hela0.94148482
151ELF1_20517297_ChIP-Seq_JURKAT_Human0.93850102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.90481740
2MP0003123_paternal_imprinting3.34911710
3MP0003693_abnormal_embryo_hatching3.20507061
4MP0003111_abnormal_nucleus_morphology3.15335669
5MP0002877_abnormal_melanocyte_morpholog2.83759483
6MP0004957_abnormal_blastocyst_morpholog2.80977503
7MP0003566_abnormal_cell_adhesion2.72615301
8MP0010094_abnormal_chromosome_stability2.52214681
9MP0005451_abnormal_body_composition2.51485798
10MP0003283_abnormal_digestive_organ2.50621285
11MP0003635_abnormal_synaptic_transmissio2.44585213
12MP0003880_abnormal_central_pattern2.36843644
13MP0003122_maternal_imprinting2.36396608
14MP0003077_abnormal_cell_cycle2.29875258
15MP0004270_analgesia2.19925898
16MP0001968_abnormal_touch/_nociception2.08547677
17* MP0001730_embryonic_growth_arrest2.02863723
18MP0000537_abnormal_urethra_morphology2.00699511
19MP0002796_impaired_skin_barrier1.94847342
20MP0003121_genomic_imprinting1.93796954
21MP0002063_abnormal_learning/memory/cond1.92990302
22MP0008438_abnormal_cutaneous_collagen1.91648152
23MP0005423_abnormal_somatic_nervous1.84496547
24MP0000678_abnormal_parathyroid_gland1.82054491
25MP0005257_abnormal_intraocular_pressure1.80787769
26MP0003119_abnormal_digestive_system1.80566103
27MP0004185_abnormal_adipocyte_glucose1.79523988
28MP0000003_abnormal_adipose_tissue1.79067239
29MP0008057_abnormal_DNA_replication1.78914915
30MP0008877_abnormal_DNA_methylation1.71103392
31MP0003091_abnormal_cell_migration1.69982332
32MP0005501_abnormal_skin_physiology1.69816072
33MP0004811_abnormal_neuron_physiology1.69238746
34MP0002653_abnormal_ependyma_morphology1.68846846
35MP0004858_abnormal_nervous_system1.67635398
36MP0009745_abnormal_behavioral_response1.67474085
37MP0004272_abnormal_basement_membrane1.67294432
38MP0003453_abnormal_keratinocyte_physiol1.66961050
39MP0008260_abnormal_autophagy1.66648339
40MP0000350_abnormal_cell_proliferation1.65733267
41MP0002736_abnormal_nociception_after1.63877759
42MP0002064_seizures1.63267553
43MP0002733_abnormal_thermal_nociception1.61743370
44MP0010234_abnormal_vibrissa_follicle1.61406046
45MP0008932_abnormal_embryonic_tissue1.61258662
46MP0010352_gastrointestinal_tract_polyps1.59224373
47MP0002089_abnormal_postnatal_growth/wei1.58193209
48MP0000579_abnormal_nail_morphology1.56284539
49MP0002734_abnormal_mechanical_nocicepti1.55888083
50MP0002060_abnormal_skin_morphology1.50389161
51MP0006276_abnormal_autonomic_nervous1.48468500
52MP0005409_darkened_coat_color1.46750873
53MP0005076_abnormal_cell_differentiation1.46446518
54* MP0002084_abnormal_developmental_patter1.43289187
55MP0001529_abnormal_vocalization1.42464259
56MP0004233_abnormal_muscle_weight1.42414544
57MP0009046_muscle_twitch1.41463687
58MP0002184_abnormal_innervation1.40617473
59* MP0001697_abnormal_embryo_size1.39389051
60MP0002572_abnormal_emotion/affect_behav1.39223014
61MP0003890_abnormal_embryonic-extraembry1.38646684
62MP0002909_abnormal_adrenal_gland1.37839075
63MP0008007_abnormal_cellular_replicative1.35151871
64MP0001440_abnormal_grooming_behavior1.34959412
65MP0004197_abnormal_fetal_growth/weight/1.33774501
66MP0002249_abnormal_larynx_morphology1.33372756
67* MP0002080_prenatal_lethality1.32960016
68MP0002735_abnormal_chemical_nociception1.32581683
69MP0000733_abnormal_muscle_development1.31536785
70MP0003861_abnormal_nervous_system1.31127988
71* MP0002085_abnormal_embryonic_tissue1.30288674
72MP0005023_abnormal_wound_healing1.28943265
73MP0003705_abnormal_hypodermis_morpholog1.27071135
74MP0003787_abnormal_imprinting1.25447140
75MP0001970_abnormal_pain_threshold1.25122791
76MP0000955_abnormal_spinal_cord1.24753784
77* MP0005380_embryogenesis_phenotype1.24364700
78* MP0001672_abnormal_embryogenesis/_devel1.24364700
79MP0005621_abnormal_cell_physiology1.23736911
80MP0005499_abnormal_olfactory_system1.23373908
81MP0005394_taste/olfaction_phenotype1.23373908
82MP0005058_abnormal_lysosome_morphology1.21597763
83MP0001346_abnormal_lacrimal_gland1.20522285
84MP0002152_abnormal_brain_morphology1.19063217
85MP0009840_abnormal_foam_cell1.18686653
86MP0002822_catalepsy1.16515485
87MP0003329_amyloid_beta_deposits1.15823721
88MP0010307_abnormal_tumor_latency1.14701186
89MP0009780_abnormal_chondrocyte_physiolo1.13425957
90MP0004133_heterotaxia1.12907491
91MP0010030_abnormal_orbit_morphology1.12212261
92MP0000467_abnormal_esophagus_morphology1.11856394
93MP0005375_adipose_tissue_phenotype1.11224950
94MP0000778_abnormal_nervous_system1.11040085
95MP0009672_abnormal_birth_weight1.10554495
96MP0008961_abnormal_basal_metabolism1.07441751
97MP0000751_myopathy1.06718188
98MP0000013_abnormal_adipose_tissue1.06188317
99MP0003984_embryonic_growth_retardation1.05123806
100MP0004924_abnormal_behavior1.05005063
101MP0005386_behavior/neurological_phenoty1.05005063
102MP0008770_decreased_survivor_rate1.04645164
103MP0008058_abnormal_DNA_repair1.04452622
104MP0000762_abnormal_tongue_morphology1.04385223
105MP0002272_abnormal_nervous_system1.04358369
106MP0002751_abnormal_autonomic_nervous1.04345857
107MP0003941_abnormal_skin_development1.04171524
108MP0002088_abnormal_embryonic_growth/wei1.04027720
109MP0000566_synostosis1.02974941
110MP0001216_abnormal_epidermal_layer1.02194544
111* MP0002086_abnormal_extraembryonic_tissu1.01951878
112MP0000534_abnormal_ureter_morphology0.99390715
113MP0002882_abnormal_neuron_morphology0.96812794
114MP0009278_abnormal_bone_marrow0.96248460
115MP0002557_abnormal_social/conspecific_i0.95391116
116MP0005623_abnormal_meninges_morphology0.94899293
117MP0004808_abnormal_hematopoietic_stem0.94107733
118MP0000358_abnormal_cell_content/0.92182776
119MP0003315_abnormal_perineum_morphology0.91389920
120MP0005384_cellular_phenotype0.90712240
121MP0002066_abnormal_motor_capabilities/c0.90576013
122MP0005666_abnormal_adipose_tissue0.90084823
123MP0009703_decreased_birth_body0.90042618
124MP0002067_abnormal_sensory_capabilities0.89902942
125MP0005187_abnormal_penis_morphology0.89748148
126MP0003115_abnormal_respiratory_system0.87327250
127MP0006072_abnormal_retinal_apoptosis0.86741317
128MP0001348_abnormal_lacrimal_gland0.86679174
129MP0003385_abnormal_body_wall0.85906780
130MP0000858_altered_metastatic_potential0.82855181
131MP0010771_integument_phenotype0.82375522
132MP0005410_abnormal_fertilization0.82331096
133MP0003942_abnormal_urinary_system0.81697207
134MP0002234_abnormal_pharynx_morphology0.81310378
135MP0003950_abnormal_plasma_membrane0.81220737
136MP0001661_extended_life_span0.80215434
137MP0001486_abnormal_startle_reflex0.80124382
138MP0003279_aneurysm0.79802996
139MP0003698_abnormal_male_reproductive0.79211702
140MP0001849_ear_inflammation0.78706048
141MP0001243_abnormal_dermal_layer0.78463173
142MP0001299_abnormal_eye_distance/0.77804798
143MP0000759_abnormal_skeletal_muscle0.77246572
144MP0002081_perinatal_lethality0.75957097
145MP0009053_abnormal_anal_canal0.75400938
146MP0000747_muscle_weakness0.75237314
147MP0003634_abnormal_glial_cell0.74603557
148MP0008789_abnormal_olfactory_epithelium0.74347719
149MP0004947_skin_inflammation0.74039016
150MP0001727_abnormal_embryo_implantation0.72982647
151MP0000428_abnormal_craniofacial_morphol0.72822432
152MP0008872_abnormal_physiological_respon0.72598084
153MP0009931_abnormal_skin_appearance0.72386191
154MP0002697_abnormal_eye_size0.71845948
155MP0000490_abnormal_crypts_of0.71790347
156MP0001915_intracranial_hemorrhage0.71424002
157MP0000313_abnormal_cell_death0.71240261
158MP0010368_abnormal_lymphatic_system0.67815618
159MP0003879_abnormal_hair_cell0.67079064

Predicted human phenotypes

RankGene SetZ-score
1Visual hallucinations (HP:0002367)4.18159163
2Myokymia (HP:0002411)3.96355727
3Abnormality of the lower motor neuron (HP:0002366)3.91072785
4Ependymoma (HP:0002888)3.64887653
5Premature rupture of membranes (HP:0001788)3.46079970
6Ulnar bowing (HP:0003031)3.33606832
7Abnormality of the labia minora (HP:0012880)3.32424511
8Insomnia (HP:0100785)3.21654004
9Distal lower limb amyotrophy (HP:0008944)3.13893362
10Protrusio acetabuli (HP:0003179)3.10959680
11Abnormality of the astrocytes (HP:0100707)3.09012295
12Astrocytoma (HP:0009592)3.09012295
13Focal seizures (HP:0007359)2.92289448
14Amyotrophic lateral sclerosis (HP:0007354)2.91920484
15Broad face (HP:0000283)2.86672671
16Focal motor seizures (HP:0011153)2.84771309
17Hyperacusis (HP:0010780)2.78766062
18Shoulder girdle muscle weakness (HP:0003547)2.76108071
19Abnormality of the Achilles tendon (HP:0005109)2.75747989
20Lower limb amyotrophy (HP:0007210)2.69210832
21Atrophy/Degeneration involving motor neurons (HP:0007373)2.64236645
22Shallow orbits (HP:0000586)2.63796806
23Adenoma sebaceum (HP:0009720)2.63234559
24Angiofibromas (HP:0010615)2.63234559
25Pointed chin (HP:0000307)2.62951273
26Long palpebral fissure (HP:0000637)2.55142243
27Obstructive sleep apnea (HP:0002870)2.52607509
28Resting tremor (HP:0002322)2.51023779
29Renal duplication (HP:0000075)2.48699386
30Spinal rigidity (HP:0003306)2.43831704
31Papilledema (HP:0001085)2.40795912
32Short nail (HP:0001799)2.40320398
33Ankyloglossia (HP:0010296)2.39364149
34Absence seizures (HP:0002121)2.37895192
35Difficulty climbing stairs (HP:0003551)2.37637630
36Increased connective tissue (HP:0009025)2.37539283
37Impaired vibration sensation in the lower limbs (HP:0002166)2.35812795
38Increased nuchal translucency (HP:0010880)2.35228818
39Pelvic girdle muscle weakness (HP:0003749)2.34706638
40Disproportionate tall stature (HP:0001519)2.34468506
41Vertebral compression fractures (HP:0002953)2.33642423
42Trismus (HP:0000211)2.31729443
43Abnormality of the anterior horn cell (HP:0006802)2.31094345
44Degeneration of anterior horn cells (HP:0002398)2.31094345
45Stridor (HP:0010307)2.27859557
46Glioma (HP:0009733)2.26724834
47Fragile skin (HP:0001030)2.26564297
48Colon cancer (HP:0003003)2.25941134
49Urinary urgency (HP:0000012)2.24916533
50Ankle contracture (HP:0006466)2.24135711
51Atrophic scars (HP:0001075)2.24122488
52Delusions (HP:0000746)2.19972236
53Limb dystonia (HP:0002451)2.19466005
54Termporal pattern (HP:0011008)2.19289107
55Insidious onset (HP:0003587)2.19289107
56Carpal bone hypoplasia (HP:0001498)2.17005660
57Cerebral hypomyelination (HP:0006808)2.16776052
58Orthostatic hypotension (HP:0001278)2.15807844
59Impaired smooth pursuit (HP:0007772)2.14707061
60Deep palmar crease (HP:0006191)2.13446134
61Cerebral aneurysm (HP:0004944)2.13197083
62Distal lower limb muscle weakness (HP:0009053)2.11442821
63Progressive muscle weakness (HP:0003323)2.10286098
64Dysmetric saccades (HP:0000641)2.09908994
65Elfin facies (HP:0004428)2.05869208
66Abnormality of oral frenula (HP:0000190)2.05838968
67Dialeptic seizures (HP:0011146)2.05797948
68Medulloblastoma (HP:0002885)2.05140330
69Bowel diverticulosis (HP:0005222)2.04670115
70Abnormality of the hip-girdle musculature (HP:0001445)2.03187692
71Abnormality of the musculature of the pelvis (HP:0001469)2.03187692
72Amblyopia (HP:0000646)2.02483711
73Overriding aorta (HP:0002623)2.01356952
74Abnormality of the distal phalanx of the thumb (HP:0009617)2.00925302
75Turricephaly (HP:0000262)2.00604141
76Broad distal phalanx of finger (HP:0009836)2.00584909
77Natal tooth (HP:0000695)1.99636117
78Basal cell carcinoma (HP:0002671)1.99490414
79Hand muscle atrophy (HP:0009130)1.99305647
80Deviation of the thumb (HP:0009603)1.98593126
81Megalocornea (HP:0000485)1.97547912
82Abnormality of the distal phalanges of the toes (HP:0010182)1.96934456
83Missing ribs (HP:0000921)1.96396271
84Elbow flexion contracture (HP:0002987)1.96194794
85Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.96090693
86Selective tooth agenesis (HP:0001592)1.94825985
87Depression (HP:0000716)1.93211868
88Patellar dislocation (HP:0002999)1.92139981
89Rhabdomyosarcoma (HP:0002859)1.90775020
90Mitral regurgitation (HP:0001653)1.90648780
91Abnormality of ocular smooth pursuit (HP:0000617)1.90345642
92Advanced eruption of teeth (HP:0006288)1.89410808
93Urethral obstruction (HP:0000796)1.89220332
94Ankle clonus (HP:0011448)1.89119836
95Neoplasm of striated muscle (HP:0009728)1.87164347
96Renovascular hypertension (HP:0100817)1.87015439
97Hypercortisolism (HP:0001578)1.86947264
98Proximal placement of thumb (HP:0009623)1.86553537
99Abnormality of the motor neurons (HP:0002450)1.86209859
100Abnormal neuron morphology (HP:0012757)1.86209859
101Generalized amyotrophy (HP:0003700)1.85649581
102Arnold-Chiari malformation (HP:0002308)1.85271213
103Biconcave vertebral bodies (HP:0004586)1.85105515
104Centrally nucleated skeletal muscle fibers (HP:0003687)1.85055346
105Cholecystitis (HP:0001082)1.83461375
106Abnormal gallbladder physiology (HP:0012438)1.83461375
107Dysautonomia (HP:0002459)1.83417799
108Intestinal polyp (HP:0005266)1.83369794
109Intestinal polyposis (HP:0200008)1.82622191
110Abnormal number of incisors (HP:0011064)1.82330742
111Sacral dimple (HP:0000960)1.80511442
112Heterotopia (HP:0002282)1.80414471
113Cerebral inclusion bodies (HP:0100314)1.80108787
114Urinary bladder sphincter dysfunction (HP:0002839)1.79042819
115Bladder diverticulum (HP:0000015)1.78871997
116Back pain (HP:0003418)1.78182448
117Failure to thrive in infancy (HP:0001531)1.77993213
118Wormian bones (HP:0002645)1.77987288
119Primitive neuroectodermal tumor (HP:0030065)1.77476384
120Neuroblastic tumors (HP:0004376)1.77476384
121Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.77476384
122Neuroblastoma (HP:0003006)1.77476384
123Genu recurvatum (HP:0002816)1.77283403
124Impulsivity (HP:0100710)1.77251566
125Supranuclear gaze palsy (HP:0000605)1.77203331
126Poor eye contact (HP:0000817)1.76726722
127Spinal cord compression (HP:0002176)1.75497332
128Hyperthyroidism (HP:0000836)1.75344174
129Impaired pain sensation (HP:0007328)1.74918066
130Abnormality of pain sensation (HP:0010832)1.74918066
131Glossoptosis (HP:0000162)1.74026975
132Bradykinesia (HP:0002067)1.73717982
133Upper limb amyotrophy (HP:0009129)1.73486352
134Distal upper limb amyotrophy (HP:0007149)1.73486352
135Bowing of the arm (HP:0006488)1.72228565
136Bowed forearm bones (HP:0003956)1.72228565
137Generalized tonic-clonic seizures (HP:0002069)1.71996438
138Flattened epiphyses (HP:0003071)1.71537297
139Sparse lateral eyebrow (HP:0005338)1.70487020
140Attention deficit hyperactivity disorder (HP:0007018)1.70439967
141Fibroma (HP:0010614)1.70330205
142Rapidly progressive (HP:0003678)1.70159540
143Hypopigmentation of the fundus (HP:0007894)1.69650454
144Distal sensory impairment (HP:0002936)1.69166918
145Flat acetabular roof (HP:0003180)1.69155020
146Abnormality of the umbilical cord (HP:0010881)1.68854542
147Achilles tendon contracture (HP:0001771)1.68294383
148Cervical subluxation (HP:0003308)1.68292296
149Atonic seizures (HP:0010819)1.68143298
150Osteolytic defects of the hand bones (HP:0009699)1.68028771
151Osteolytic defects of the phalanges of the hand (HP:0009771)1.68028771
152Neoplasm of the heart (HP:0100544)1.67526515
153Truncal ataxia (HP:0002078)1.67120459
154Personality changes (HP:0000751)1.66911353
155Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.66873005
156Dislocated radial head (HP:0003083)1.66368953
157Abnormal social behavior (HP:0012433)1.66198591
158Impaired social interactions (HP:0000735)1.66198591
159Truncus arteriosus (HP:0001660)1.65951468
160Abnormality of the salivary glands (HP:0010286)1.65850554
161Premature skin wrinkling (HP:0100678)1.65059016
162Abnormal ossification of hand bones (HP:0005921)1.64806854
163Annular pancreas (HP:0001734)1.64562611
164Flared metaphyses (HP:0003015)1.62645436
165Upper limb muscle weakness (HP:0003484)1.62595335
166Progressive hearing impairment (HP:0001730)1.62197840
167Mildly elevated creatine phosphokinase (HP:0008180)1.61675942
168Hyperparathyroidism (HP:0000843)1.60490744
169Asymmetry of the thorax (HP:0001555)1.59780240
170Breast hypoplasia (HP:0003187)1.59195820
171Insulin resistance (HP:0000855)1.58955069
172Blue sclerae (HP:0000592)1.57951860
173Precocious puberty (HP:0000826)1.57461054
174Abnormality of the calcaneus (HP:0008364)1.56570211
175Acanthosis nigricans (HP:0000956)1.55939355
176Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.55773084
177Absent epiphyses (HP:0010577)1.55773084

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.09792952
2BUB13.15908512
3MAP3K93.11427160
4CDC72.94395227
5NEK12.88065901
6IRAK32.59566426
7PNCK2.47069884
8PRPF4B2.46200114
9WEE12.35604135
10LATS22.24511360
11SIK12.22703053
12MINK12.18618390
13NTRK32.15828184
14NME22.15649090
15EEF2K2.12479376
16MARK12.06750287
17TSSK62.03490891
18SCYL21.96923257
19PRKD31.93597605
20MST1R1.92768313
21NEK21.92369949
22KSR21.86397424
23TTN1.85347394
24PKN21.76828289
25ALK1.71464721
26RIPK11.63994178
27UHMK11.61495100
28BRSK11.58875715
29MAP3K41.56359076
30TESK11.55676641
31PAK61.54962117
32TRIB31.52938331
33PASK1.49386481
34TTK1.46297013
35KSR11.42500185
36PTK21.42198384
37PLK31.34731924
38MAP3K101.34499865
39TESK21.33141855
40NTRK11.32816589
41CDK121.32213665
42AURKA1.29872133
43TYRO31.29049666
44PLK11.27249326
45NTRK21.26367694
46LIMK11.23810790
47ICK1.19618180
48DAPK11.19041503
49CDK141.18679272
50CDK181.18291582
51CDK151.17762335
52FGFR41.15585673
53TAOK21.09196975
54CDK11A1.08355405
55ERN11.04875582
56SIK21.02483104
57MAP3K81.00024287
58MET0.96450128
59LMTK20.95021084
60EPHA20.94739943
61TLK10.94039016
62CAMKK10.93682841
63CHEK10.90370012
64GRK50.88811218
65RPS6KB20.87842571
66CCNB10.87660283
67DAPK20.85940050
68PLK20.84254712
69PAK20.82470418
70CHEK20.82290182
71TAOK10.81959107
72RPS6KA20.81614667
73CSNK1E0.80968057
74MAP3K130.80565906
75EPHA40.80201516
76MAP3K20.80077406
77AURKB0.79279064
78PDPK10.77971776
79GRK60.76701573
80PDK30.74076691
81PDK40.74076691
82CAMK1D0.73895216
83MAPK110.73750874
84CAMK1G0.73422844
85STK380.72133412
86CDK50.71680314
87RET0.71613556
88* CDK20.71121399
89EIF2AK10.70836276
90MAP2K40.70242411
91MAP2K30.70145366
92PTK60.69274695
93BRSK20.69187482
94CDK80.69177047
95CDK40.67288899
96MARK20.67279454
97DDR20.65840554
98PDGFRA0.64928932
99PRKCG0.64572239
100ATR0.63875686
101PIM20.63818528
102PRKD20.61748270
103IRAK20.61531953
104PAK10.60866137
105BRD40.60094211
106CDK70.59745001
107MTOR0.58766226
108MAP3K120.58719036
109VRK20.58423202
110MAP3K110.58134021
111MAP3K10.56838588
112SRPK10.56793185
113* CDK10.56646865
114ARAF0.53576776
115PRKCI0.53422507
116BRAF0.52634566
117PAK40.51999594
118CSNK1G20.50758623
119PRKG20.49780732
120FGFR10.49634331
121PBK0.49470803
122ILK0.49288253
123CDK90.47892430
124STK110.47214370
125RPS6KL10.47155259
126RPS6KC10.47155259
127BMX0.46332662
128CDK60.46047164
129CSNK2A20.45798400
130CDC42BPA0.45734191
131MAP2K20.45102770
132AKT20.44811646
133STK100.44727613
134MAP3K30.43561190
135ATM0.42776609
136DAPK30.42105891
137CSNK1G30.41445661
138PAK30.41310678
139MAPK100.40370037
140NME10.39755060
141FER0.38851891
142ERBB40.38482377
143RAF10.37752935
144LRRK20.37586525

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.64265071
2DNA replication_Homo sapiens_hsa030302.57374470
3* RNA transport_Homo sapiens_hsa030132.42025010
4Oocyte meiosis_Homo sapiens_hsa041142.33061966
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.31760067
6Mismatch repair_Homo sapiens_hsa034302.28990983
7Spliceosome_Homo sapiens_hsa030402.17805747
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15813980
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.15727422
10Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.88220782
11Cell cycle_Homo sapiens_hsa041101.85667036
12Vitamin B6 metabolism_Homo sapiens_hsa007501.85061907
13Long-term potentiation_Homo sapiens_hsa047201.81842362
14mRNA surveillance pathway_Homo sapiens_hsa030151.80439998
15Nicotine addiction_Homo sapiens_hsa050331.70381197
16Sulfur relay system_Homo sapiens_hsa041221.64690461
17Amphetamine addiction_Homo sapiens_hsa050311.64470003
18Dopaminergic synapse_Homo sapiens_hsa047281.61216385
19One carbon pool by folate_Homo sapiens_hsa006701.55617595
20Alcoholism_Homo sapiens_hsa050341.50361823
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50330238
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48011400
23Pentose phosphate pathway_Homo sapiens_hsa000301.46476499
24Olfactory transduction_Homo sapiens_hsa047401.42562065
25Gap junction_Homo sapiens_hsa045401.35617476
26Glioma_Homo sapiens_hsa052141.34594745
27Acute myeloid leukemia_Homo sapiens_hsa052211.34485462
28Base excision repair_Homo sapiens_hsa034101.34460669
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33382542
30Estrogen signaling pathway_Homo sapiens_hsa049151.30251377
31Ribosome_Homo sapiens_hsa030101.30209477
32Nucleotide excision repair_Homo sapiens_hsa034201.30126563
33Pancreatic cancer_Homo sapiens_hsa052121.27226824
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.26409081
35mTOR signaling pathway_Homo sapiens_hsa041501.24553079
36GABAergic synapse_Homo sapiens_hsa047271.22996145
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22848191
38Cocaine addiction_Homo sapiens_hsa050301.22775642
39Proteasome_Homo sapiens_hsa030501.22121134
40Notch signaling pathway_Homo sapiens_hsa043301.21637610
41Insulin secretion_Homo sapiens_hsa049111.20432777
42Fructose and mannose metabolism_Homo sapiens_hsa000511.15098323
43Focal adhesion_Homo sapiens_hsa045101.15012525
44Circadian entrainment_Homo sapiens_hsa047131.13031978
45Thyroid cancer_Homo sapiens_hsa052161.11963485
46Small cell lung cancer_Homo sapiens_hsa052221.11341021
47Proteoglycans in cancer_Homo sapiens_hsa052051.08224043
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07001553
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05660934
50Cholinergic synapse_Homo sapiens_hsa047251.03870787
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01963872
52Adherens junction_Homo sapiens_hsa045201.00776560
53Biosynthesis of amino acids_Homo sapiens_hsa012300.98712795
54Glutamatergic synapse_Homo sapiens_hsa047240.98618916
55Lysine degradation_Homo sapiens_hsa003100.97208199
56Carbon metabolism_Homo sapiens_hsa012000.95755944
57Morphine addiction_Homo sapiens_hsa050320.95473735
58Colorectal cancer_Homo sapiens_hsa052100.95419750
59Melanogenesis_Homo sapiens_hsa049160.94049028
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93262479
61Galactose metabolism_Homo sapiens_hsa000520.92584050
62Endometrial cancer_Homo sapiens_hsa052130.92311808
63Hippo signaling pathway_Homo sapiens_hsa043900.91825253
64ECM-receptor interaction_Homo sapiens_hsa045120.88242402
65Bladder cancer_Homo sapiens_hsa052190.87612490
66Prostate cancer_Homo sapiens_hsa052150.87344757
67ErbB signaling pathway_Homo sapiens_hsa040120.86886004
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86264246
69Long-term depression_Homo sapiens_hsa047300.85443618
70Non-small cell lung cancer_Homo sapiens_hsa052230.85424253
71Inositol phosphate metabolism_Homo sapiens_hsa005620.85173433
72N-Glycan biosynthesis_Homo sapiens_hsa005100.84249356
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.84092150
74RNA polymerase_Homo sapiens_hsa030200.83674268
75Viral carcinogenesis_Homo sapiens_hsa052030.82022211
76AMPK signaling pathway_Homo sapiens_hsa041520.81919797
77Other glycan degradation_Homo sapiens_hsa005110.81732568
78GnRH signaling pathway_Homo sapiens_hsa049120.81268790
79VEGF signaling pathway_Homo sapiens_hsa043700.80780401
80Oxytocin signaling pathway_Homo sapiens_hsa049210.80734874
81Hedgehog signaling pathway_Homo sapiens_hsa043400.80525888
82Gastric acid secretion_Homo sapiens_hsa049710.80213363
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79947529
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79907427
85Apoptosis_Homo sapiens_hsa042100.79682302
86Endocytosis_Homo sapiens_hsa041440.79592607
87Systemic lupus erythematosus_Homo sapiens_hsa053220.79106562
88Vibrio cholerae infection_Homo sapiens_hsa051100.79099170
89Glucagon signaling pathway_Homo sapiens_hsa049220.79045569
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78093336
91Type II diabetes mellitus_Homo sapiens_hsa049300.78030936
92Pyrimidine metabolism_Homo sapiens_hsa002400.75739500
93Salivary secretion_Homo sapiens_hsa049700.75107435
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73352597
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72206947
96Collecting duct acid secretion_Homo sapiens_hsa049660.71674770
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71036788
98Fatty acid biosynthesis_Homo sapiens_hsa000610.70968093
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.70724823
100Shigellosis_Homo sapiens_hsa051310.70355447
101HTLV-I infection_Homo sapiens_hsa051660.70283518
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.70152989
103Homologous recombination_Homo sapiens_hsa034400.69539965
104Insulin signaling pathway_Homo sapiens_hsa049100.69235867
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68492561
106Hepatitis B_Homo sapiens_hsa051610.68199036
107Taste transduction_Homo sapiens_hsa047420.68030385
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64160680
109Arginine biosynthesis_Homo sapiens_hsa002200.63180145
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.62974916
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62507960
112Wnt signaling pathway_Homo sapiens_hsa043100.62002363
113Basal cell carcinoma_Homo sapiens_hsa052170.61444301
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60804547
115Melanoma_Homo sapiens_hsa052180.60275092
116p53 signaling pathway_Homo sapiens_hsa041150.60113507
117Renin secretion_Homo sapiens_hsa049240.59764054
118Epstein-Barr virus infection_Homo sapiens_hsa051690.58773799
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58208527
120Chronic myeloid leukemia_Homo sapiens_hsa052200.57521616
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56846695
122Dorso-ventral axis formation_Homo sapiens_hsa043200.56802401
123Axon guidance_Homo sapiens_hsa043600.56777907
124Choline metabolism in cancer_Homo sapiens_hsa052310.56357746
125Serotonergic synapse_Homo sapiens_hsa047260.56355524
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56180494
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54825379
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54518567
129RNA degradation_Homo sapiens_hsa030180.53534148
130Renal cell carcinoma_Homo sapiens_hsa052110.53394957
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53297482
132HIF-1 signaling pathway_Homo sapiens_hsa040660.53242071
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52726676
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52645749
135Prion diseases_Homo sapiens_hsa050200.50950591
136Prolactin signaling pathway_Homo sapiens_hsa049170.50622347
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50585746
138MicroRNAs in cancer_Homo sapiens_hsa052060.49809174
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49746483
140Tight junction_Homo sapiens_hsa045300.49126894
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.48915082
142Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46987477

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »