RANP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.17032388
2cytidine metabolic process (GO:0046087)7.05454299
3cytidine catabolic process (GO:0006216)7.05454299
4cytidine deamination (GO:0009972)7.05454299
5pyrimidine ribonucleoside catabolic process (GO:0046133)6.26459661
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.92952440
7tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.34224687
8RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.34224687
9proteasome assembly (GO:0043248)5.02758759
10regulation of regulatory T cell differentiation (GO:0045589)4.10409861
11regulation of cellular amino acid metabolic process (GO:0006521)3.97633337
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.90739502
13DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.85193653
14positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.75702117
15signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.74969546
16signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.74969546
17signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.74969546
18signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.74779709
19intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.74779709
20regulation of isotype switching to IgG isotypes (GO:0048302)3.73305632
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.65293398
22positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.61563945
23positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.60051942
24positive regulation of interleukin-17 production (GO:0032740)3.54268602
25signal transduction involved in DNA damage checkpoint (GO:0072422)3.54222057
26signal transduction involved in DNA integrity checkpoint (GO:0072401)3.54222057
27positive regulation of natural killer cell mediated immunity (GO:0002717)3.53196793
28negative regulation of ligase activity (GO:0051352)3.51039894
29negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.51039894
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.49421308
31signal transduction involved in cell cycle checkpoint (GO:0072395)3.49079698
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45266743
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.43179722
34ATP synthesis coupled proton transport (GO:0015986)3.43179722
35regulation of chronic inflammatory response (GO:0002676)3.42576103
36pseudouridine synthesis (GO:0001522)3.41955868
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.32343535
38positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.32018911
39regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.27743115
40antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.25540080
41adenosine metabolic process (GO:0046085)3.24862732
42rRNA modification (GO:0000154)3.22522721
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.21037235
44positive regulation of interleukin-8 secretion (GO:2000484)3.20811566
45cytolysis (GO:0019835)3.15829259
46negative regulation of T cell apoptotic process (GO:0070233)3.14993539
47pyrimidine nucleoside catabolic process (GO:0046135)3.13326812
48DNA ligation (GO:0006266)3.10512056
49folic acid-containing compound biosynthetic process (GO:0009396)3.10423037
50positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.09878547
51positive regulation of cell cycle arrest (GO:0071158)3.01383206
52positive regulation of B cell differentiation (GO:0045579)3.00333511
53regulation of leukocyte mediated cytotoxicity (GO:0001910)2.99700633
54positive regulation of ligase activity (GO:0051351)2.98441459
55regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.97688291
56regulation of natural killer cell mediated immunity (GO:0002715)2.97688291
57establishment of protein localization to mitochondrial membrane (GO:0090151)2.97095498
58protein complex biogenesis (GO:0070271)2.96940273
59respiratory electron transport chain (GO:0022904)2.95116540
60tRNA processing (GO:0008033)2.95103287
61positive regulation of T cell mediated cytotoxicity (GO:0001916)2.90978201
62DNA double-strand break processing (GO:0000729)2.90840172
63electron transport chain (GO:0022900)2.90595487
64DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.89572849
65mitochondrial RNA metabolic process (GO:0000959)2.87311010
66pyrimidine ribonucleoside metabolic process (GO:0046131)2.87019292
67rRNA methylation (GO:0031167)2.86918485
68positive regulation of cell killing (GO:0031343)2.85904944
69negative regulation of lymphocyte apoptotic process (GO:0070229)2.85532097
70positive regulation of DNA recombination (GO:0045911)2.84606123
71T cell migration (GO:0072678)2.78803340
72platelet dense granule organization (GO:0060155)2.78137893
73protein-cofactor linkage (GO:0018065)2.77056952
74regulation of immunoglobulin secretion (GO:0051023)2.76547317
75water-soluble vitamin biosynthetic process (GO:0042364)2.75337530
76regulation of cellular amine metabolic process (GO:0033238)2.74419469
77mitochondrial respiratory chain complex assembly (GO:0033108)2.72628323
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72565223
79protein neddylation (GO:0045116)2.71776516
80regulation of activation of Janus kinase activity (GO:0010533)2.71689601
81positive regulation of T cell migration (GO:2000406)2.71459536
82maturation of 5.8S rRNA (GO:0000460)2.71389727
83positive regulation of defense response to virus by host (GO:0002230)2.71077142
84ribosome biogenesis (GO:0042254)2.70576638
85regulation of cell cycle arrest (GO:0071156)2.69551525
86negative regulation by host of viral transcription (GO:0043922)2.68589576
87DNA dealkylation (GO:0035510)2.68451440
88regulation of cell killing (GO:0031341)2.66731998
89protein targeting to mitochondrion (GO:0006626)2.66385441
90deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.65000036
91regulation of T cell mediated cytotoxicity (GO:0001914)2.64301724
92positive regulation of isotype switching (GO:0045830)2.63932797
93positive T cell selection (GO:0043368)2.63819002
94positive regulation of lymphocyte migration (GO:2000403)2.62780892
95DNA catabolic process, exonucleolytic (GO:0000738)2.62647908
96DNA demethylation (GO:0080111)2.62446652
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.62050257
98chaperone-mediated protein transport (GO:0072321)2.62023262
99L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.60987700
100purine nucleotide salvage (GO:0032261)2.59923259

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.78828908
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.08109528
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.23223501
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.01962132
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.68227902
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.51332726
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.33064229
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.10384937
9VDR_22108803_ChIP-Seq_LS180_Human2.69069368
10VDR_23849224_ChIP-Seq_CD4+_Human2.68534405
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62344826
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.60180011
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.47617303
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44435212
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.40107788
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.33046470
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31428121
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.27433700
19ELK1_19687146_ChIP-ChIP_HELA_Human2.26828346
20FOXP3_21729870_ChIP-Seq_TREG_Human2.23050337
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.13223736
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.12100843
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10952037
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.10795069
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02675782
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.92586222
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.81224229
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.76720068
29E2F7_22180533_ChIP-Seq_HELA_Human1.74460552
30MYB_26560356_Chip-Seq_TH2_Human1.64981022
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60840939
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.60578516
33ZNF274_21170338_ChIP-Seq_K562_Hela1.58358621
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58155938
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.58100147
36DCP1A_22483619_ChIP-Seq_HELA_Human1.55357547
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54271727
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.51187382
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50952286
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50191645
41GATA3_26560356_Chip-Seq_TH2_Human1.48071936
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46856437
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.43117421
44CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39627771
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38458703
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37937808
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36859571
48TP53_22573176_ChIP-Seq_HFKS_Human1.36329912
49GABP_19822575_ChIP-Seq_HepG2_Human1.36032593
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.33936775
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33628410
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32801151
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30872447
54GATA3_27048872_Chip-Seq_THYMUS_Human1.29376121
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.26213998
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25839697
57MYC_18940864_ChIP-ChIP_HL60_Human1.23147984
58EWS_26573619_Chip-Seq_HEK293_Human1.20966071
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19665481
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15468974
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14951463
62PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.11793593
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.08924934
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06704326
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.06704326
66TTF2_22483619_ChIP-Seq_HELA_Human1.04788074
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03964675
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02989017
69NANOG_19829295_ChIP-Seq_ESCs_Human1.00208379
70SOX2_19829295_ChIP-Seq_ESCs_Human1.00208379
71MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99181796
72CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97848307
73AR_20517297_ChIP-Seq_VCAP_Human0.97708556
74AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97648171
75RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97081790
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96472423
77NCOR_22424771_ChIP-Seq_293T_Human0.96276122
78POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95401685
79ERG_20517297_ChIP-Seq_VCAP_Human0.94866711
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94259056
81NANOG_20526341_ChIP-Seq_ESCs_Human0.93873413
82FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93553189
83XRN2_22483619_ChIP-Seq_HELA_Human0.93483686
84TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93197959
85NFE2_27457419_Chip-Seq_LIVER_Mouse0.91699026
86TAF2_19829295_ChIP-Seq_ESCs_Human0.91546817
87THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90690420
88HTT_18923047_ChIP-ChIP_STHdh_Human0.90015588
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88826908
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88612832
91MYB_26560356_Chip-Seq_TH1_Human0.88295205
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87312425
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87186814
94CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85059292
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84965414
96SPI1_23547873_ChIP-Seq_NB4_Human0.84622115
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.84610441
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84058792
99GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.83697547
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83222375

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.74842761
2MP0004147_increased_porphyrin_level3.22162008
3MP0001835_abnormal_antigen_presentation3.21065712
4MP0009333_abnormal_splenocyte_physiolog2.88723756
5MP0002102_abnormal_ear_morphology2.87988368
6MP0009785_altered_susceptibility_to2.84909296
7MP0003786_premature_aging2.78910246
8MP0003763_abnormal_thymus_physiology2.54647581
9MP0003693_abnormal_embryo_hatching2.24871627
10MP0005000_abnormal_immune_tolerance2.24356588
11MP0005646_abnormal_pituitary_gland1.97623768
12MP0006072_abnormal_retinal_apoptosis1.96725914
13MP0002736_abnormal_nociception_after1.96581593
14MP0005360_urolithiasis1.96476708
15MP0004885_abnormal_endolymph1.95948514
16MP0008877_abnormal_DNA_methylation1.91312049
17MP0001919_abnormal_reproductive_system1.89560169
18MP0001800_abnormal_humoral_immune1.88078400
19MP0002148_abnormal_hypersensitivity_rea1.85957393
20MP0008872_abnormal_physiological_respon1.82451102
21MP0003866_abnormal_defecation1.81136350
22MP0001873_stomach_inflammation1.79569473
23MP0001853_heart_inflammation1.73072186
24MP0005075_abnormal_melanosome_morpholog1.69389000
25MP0006082_CNS_inflammation1.66513770
26MP0002420_abnormal_adaptive_immunity1.64250238
27MP0002723_abnormal_immune_serum1.64008440
28MP0008058_abnormal_DNA_repair1.63279766
29MP0003878_abnormal_ear_physiology1.59210866
30MP0005377_hearing/vestibular/ear_phenot1.59210866
31MP0005387_immune_system_phenotype1.57441412
32MP0001790_abnormal_immune_system1.57441412
33MP0003646_muscle_fatigue1.56766900
34MP0008875_abnormal_xenobiotic_pharmacok1.55131014
35MP0001819_abnormal_immune_cell1.55075908
36MP0005025_abnormal_response_to1.53660318
37MP0008995_early_reproductive_senescence1.52095594
38MP0005389_reproductive_system_phenotype1.50200536
39MP0000372_irregular_coat_pigmentation1.49312503
40MP0002166_altered_tumor_susceptibility1.48793729
41MP0001968_abnormal_touch/_nociception1.48571927
42MP0010094_abnormal_chromosome_stability1.40986466
43MP0001661_extended_life_span1.40473150
44MP0003045_fibrosis1.40133769
45MP0005645_abnormal_hypothalamus_physiol1.39483164
46MP0005551_abnormal_eye_electrophysiolog1.38176953
47MP0002006_tumorigenesis1.37840408
48MP0000685_abnormal_immune_system1.37483350
49MP0000703_abnormal_thymus_morphology1.34894358
50MP0002398_abnormal_bone_marrow1.34870136
51MP0002452_abnormal_antigen_presenting1.31200922
52MP0000716_abnormal_immune_system1.28536459
53MP0000689_abnormal_spleen_morphology1.28210503
54MP0008057_abnormal_DNA_replication1.27825573
55MP0004957_abnormal_blastocyst_morpholog1.25700820
56MP0003806_abnormal_nucleotide_metabolis1.20521144
57MP0002722_abnormal_immune_system1.19906433
58MP0002138_abnormal_hepatobiliary_system1.17365004
59MP0006036_abnormal_mitochondrial_physio1.16463962
60MP0010155_abnormal_intestine_physiology1.15115603
61MP0001845_abnormal_inflammatory_respons1.14168768
62MP0002405_respiratory_system_inflammati1.13941929
63MP0002837_dystrophic_cardiac_calcinosis1.12861995
64MP0005253_abnormal_eye_physiology1.11685034
65MP0003724_increased_susceptibility_to1.11653245
66MP0003448_altered_tumor_morphology1.09236815
67MP0002429_abnormal_blood_cell1.07898092
68MP0001764_abnormal_homeostasis1.03977011
69MP0003195_calcinosis1.01659481
70MP0005410_abnormal_fertilization1.01521372
71MP0001905_abnormal_dopamine_level1.01304366
72MP0008789_abnormal_olfactory_epithelium1.00350815
73MP0003880_abnormal_central_pattern0.99760141
74MP0002938_white_spotting0.98603564
75MP0005332_abnormal_amino_acid0.95384606
76MP0002163_abnormal_gland_morphology0.95075795
77MP0005636_abnormal_mineral_homeostasis0.94807968
78MP0009764_decreased_sensitivity_to0.94688981
79MP0002019_abnormal_tumor_incidence0.94010687
80MP0002876_abnormal_thyroid_physiology0.92842799
81MP0002160_abnormal_reproductive_system0.91723185
82MP0000465_gastrointestinal_hemorrhage0.90577391
83MP0004145_abnormal_muscle_electrophysio0.88568676
84MP0001119_abnormal_female_reproductive0.87022971
85MP0005084_abnormal_gallbladder_morpholo0.85614503
86MP0006276_abnormal_autonomic_nervous0.85130122
87MP0002095_abnormal_skin_pigmentation0.84875911
88MP0008469_abnormal_protein_level0.83720871
89MP0002210_abnormal_sex_determination0.82528557
90MP0009643_abnormal_urine_homeostasis0.81656876
91MP0008873_increased_physiological_sensi0.80347738
92MP0001485_abnormal_pinna_reflex0.79815304
93MP0001348_abnormal_lacrimal_gland0.78735367
94MP0003111_abnormal_nucleus_morphology0.78227105
95MP0004742_abnormal_vestibular_system0.78065534
96MP0002735_abnormal_chemical_nociception0.77788887
97MP0001929_abnormal_gametogenesis0.76296391
98MP0008007_abnormal_cellular_replicative0.74480758
99MP0000653_abnormal_sex_gland0.72975146
100MP0001986_abnormal_taste_sensitivity0.72768656

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.83611257
2IgG deficiency (HP:0004315)4.39055863
3Hyperalaninemia (HP:0003348)4.19010433
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.19010433
5Abnormality of alanine metabolism (HP:0010916)4.19010433
6Acute necrotizing encephalopathy (HP:0006965)4.13047115
7Mitochondrial inheritance (HP:0001427)3.80029129
8Abnormal mitochondria in muscle tissue (HP:0008316)3.76574579
9Constricted visual fields (HP:0001133)3.75066060
10Elevated erythrocyte sedimentation rate (HP:0003565)3.68605571
11Acute encephalopathy (HP:0006846)3.60697173
12Hypoproteinemia (HP:0003075)3.50700904
13Stomatitis (HP:0010280)3.50423787
14Increased CSF lactate (HP:0002490)3.38721314
15Severe combined immunodeficiency (HP:0004430)3.32899604
16Cerebral edema (HP:0002181)3.30558734
17Progressive macrocephaly (HP:0004481)3.30045199
18Increased hepatocellular lipid droplets (HP:0006565)3.20966171
19T lymphocytopenia (HP:0005403)3.19547549
20Hepatocellular necrosis (HP:0001404)3.18801191
213-Methylglutaconic aciduria (HP:0003535)3.17485420
22Lipid accumulation in hepatocytes (HP:0006561)3.12221899
23B lymphocytopenia (HP:0010976)3.11108852
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.09651324
25Generalized aminoaciduria (HP:0002909)2.98848017
26Increased serum lactate (HP:0002151)2.97957438
27Increased IgM level (HP:0003496)2.93987899
28Abnormality of T cell number (HP:0011839)2.92115438
29Hepatic necrosis (HP:0002605)2.86361133
30Abnormality of B cell number (HP:0010975)2.82708875
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.82576494
32Pancytopenia (HP:0001876)2.79183519
33Renal Fanconi syndrome (HP:0001994)2.68966219
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.67839408
35Combined immunodeficiency (HP:0005387)2.66956791
36Abnormality of the prostate (HP:0008775)2.64390004
37Increased intramyocellular lipid droplets (HP:0012240)2.63381881
38Lactic acidosis (HP:0003128)2.61406265
39Thyroiditis (HP:0100646)2.58817684
40Chronic diarrhea (HP:0002028)2.55450051
41Abnormality of T cells (HP:0002843)2.52533379
42Abnormality of eosinophils (HP:0001879)2.50888803
43Optic disc pallor (HP:0000543)2.50246572
44Abnormality of serum amino acid levels (HP:0003112)2.48383192
45Lethargy (HP:0001254)2.42716388
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.36133519
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.36133519
48Oral leukoplakia (HP:0002745)2.34495236
49Pancreatic cysts (HP:0001737)2.32819669
50Increased serum pyruvate (HP:0003542)2.31321337
51Hyperglycinemia (HP:0002154)2.29321504
52Exertional dyspnea (HP:0002875)2.26899371
53Aplasia/hypoplasia of the uterus (HP:0008684)2.26862934
54Increased muscle lipid content (HP:0009058)2.26463569
55Exercise intolerance (HP:0003546)2.24142794
56Attenuation of retinal blood vessels (HP:0007843)2.18561704
57Methylmalonic acidemia (HP:0002912)2.18519414
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17685547
59Methylmalonic aciduria (HP:0012120)2.16231872
60Autoimmune hemolytic anemia (HP:0001890)2.10835390
61Hypoplasia of the thymus (HP:0000778)2.03729147
62Congenital stationary night blindness (HP:0007642)2.03638998
63Poor speech (HP:0002465)2.03058434
64IgM deficiency (HP:0002850)2.00492847
65Dicarboxylic aciduria (HP:0003215)1.95923725
66Abnormality of dicarboxylic acid metabolism (HP:0010995)1.95923725
67Neutropenia (HP:0001875)1.92708784
68Congenital, generalized hypertrichosis (HP:0004540)1.89703196
69Abnormal rod and cone electroretinograms (HP:0008323)1.89378221
70Eosinophilia (HP:0001880)1.88708876
71Abnormality of serine family amino acid metabolism (HP:0010894)1.88023156
72Abnormality of glycine metabolism (HP:0010895)1.88023156
73Abnormal albumin level (HP:0012116)1.86934203
74Hypoalbuminemia (HP:0003073)1.86934203
75Cerebral hypomyelination (HP:0006808)1.86924336
76Respiratory failure (HP:0002878)1.85503970
77Leukodystrophy (HP:0002415)1.85379979
78True hermaphroditism (HP:0010459)1.85265691
79Pancreatic fibrosis (HP:0100732)1.82206801
80Glycosuria (HP:0003076)1.82010601
81Abnormality of urine glucose concentration (HP:0011016)1.82010601
82Abnormality of T cell physiology (HP:0011840)1.81974535
83Meckel diverticulum (HP:0002245)1.80951709
84Abnormality of the ileum (HP:0001549)1.79576403
85Panhypogammaglobulinemia (HP:0003139)1.76493518
86Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.76274517
87Abnormality of glycolysis (HP:0004366)1.76081281
88Lymphoma (HP:0002665)1.76057893
89Type I transferrin isoform profile (HP:0003642)1.75365336
90Microvesicular hepatic steatosis (HP:0001414)1.75185119
91Lymphopenia (HP:0001888)1.75175159
92Pendular nystagmus (HP:0012043)1.74730944
93Abnormality of the renal collecting system (HP:0004742)1.71708575
94Hypoplasia of the uterus (HP:0000013)1.71238908
95Congenital sensorineural hearing impairment (HP:0008527)1.69953477
96Molar tooth sign on MRI (HP:0002419)1.69940157
97Abnormality of midbrain morphology (HP:0002418)1.69940157
98Carpal bone hypoplasia (HP:0001498)1.68889365
99Absent thumb (HP:0009777)1.67195922
100Abolished electroretinogram (ERG) (HP:0000550)1.66879865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.60509590
2KDR4.37262734
3VRK23.68875981
4TESK23.02930547
5BUB12.99209962
6EIF2AK32.96214946
7BCKDK2.91277558
8MAP3K92.74677684
9MST42.43749139
10EIF2AK12.42562652
11MAP4K22.23635388
12ZAK2.21743252
13NUAK12.14874699
14MAP4K11.92964000
15SRPK11.69724952
16VRK11.61601197
17ADRBK21.60411073
18ITK1.60395682
19NME11.53805731
20TAF11.52244415
21TLK11.50754226
22GRK11.50212635
23TRIM281.46901951
24GRK61.41621740
25TEC1.38828152
26SCYL21.31290354
27TIE11.30093730
28MUSK1.27851041
29FES1.26947205
30PAK41.14174831
31BMPR21.10517705
32TESK11.05200136
33TSSK61.02485874
34DAPK10.99941410
35STK160.99263332
36PLK40.99029528
37NEK10.96926385
38LIMK10.95525043
39PBK0.93275941
40CSNK1G30.92928652
41IKBKB0.89836921
42PIK3CG0.88181696
43INSRR0.85583079
44ACVR1B0.81117288
45EIF2AK20.80399299
46WNK30.79641325
47PLK30.76918350
48BMPR1B0.73789772
49CSNK1G10.72934476
50CCNB10.70495900
51SYK0.69632917
52ATR0.67990473
53LCK0.67438853
54PASK0.67026192
55AURKA0.66233231
56MYLK0.65509590
57PLK10.62751078
58CDC70.61846286
59CSK0.61337967
60PLK20.60715508
61RAF10.60227383
62CSNK1A1L0.59255817
63PAK30.55954379
64AURKB0.55138874
65MAP3K120.55060816
66CSNK1G20.54270045
67FRK0.53881530
68WNK40.53629094
69JAK30.53281377
70CSNK1A10.53094663
71PRKCQ0.52704334
72CDK90.51426448
73PAK10.50194405
74MAP2K70.49479318
75TNK20.48935362
76LYN0.48879533
77CSNK2A10.47177493
78BTK0.46225786
79TAOK30.45350162
80RPS6KA40.45167163
81CSNK2A20.44201428
82STK390.42819104
83IGF1R0.42374511
84OXSR10.42368815
85BCR0.41956480
86PINK10.41321700
87MATK0.39583670
88ADRBK10.37693277
89ERBB30.37613582
90CAMKK20.36493511
91RPS6KA50.36129607
92DYRK20.35566449
93GRK50.32778466
94KIT0.31217483
95PIM20.30590830
96TYRO30.29870466
97MAPKAPK50.29272871
98INSR0.28743850
99MKNK10.28192686
100NEK90.27602757

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.31574457
2Primary immunodeficiency_Homo sapiens_hsa053403.75415699
3Oxidative phosphorylation_Homo sapiens_hsa001903.22642139
4Parkinsons disease_Homo sapiens_hsa050122.66410332
5Protein export_Homo sapiens_hsa030602.57643097
6Autoimmune thyroid disease_Homo sapiens_hsa053202.48561356
7Allograft rejection_Homo sapiens_hsa053302.38432249
8One carbon pool by folate_Homo sapiens_hsa006702.30516139
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.26597827
10RNA polymerase_Homo sapiens_hsa030202.25987920
11Graft-versus-host disease_Homo sapiens_hsa053322.09406841
12Ribosome_Homo sapiens_hsa030101.86682550
13DNA replication_Homo sapiens_hsa030301.81610517
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77732116
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76149175
16Sulfur metabolism_Homo sapiens_hsa009201.75948004
17Type I diabetes mellitus_Homo sapiens_hsa049401.67952206
18Asthma_Homo sapiens_hsa053101.66834847
19Basal transcription factors_Homo sapiens_hsa030221.64917273
20Homologous recombination_Homo sapiens_hsa034401.63359089
21Huntingtons disease_Homo sapiens_hsa050161.62650899
22Mismatch repair_Homo sapiens_hsa034301.57901740
23Alzheimers disease_Homo sapiens_hsa050101.56816371
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.54707309
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53053544
26Spliceosome_Homo sapiens_hsa030401.51348945
27Hematopoietic cell lineage_Homo sapiens_hsa046401.48810098
28T cell receptor signaling pathway_Homo sapiens_hsa046601.44645916
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42351005
30Antigen processing and presentation_Homo sapiens_hsa046121.39254969
31Pyrimidine metabolism_Homo sapiens_hsa002401.37537484
32Propanoate metabolism_Homo sapiens_hsa006401.36748012
33RNA transport_Homo sapiens_hsa030131.35008917
34Rheumatoid arthritis_Homo sapiens_hsa053231.32081086
35RNA degradation_Homo sapiens_hsa030181.30731231
36Non-homologous end-joining_Homo sapiens_hsa034501.29648893
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27477632
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23758303
39Collecting duct acid secretion_Homo sapiens_hsa049661.22652654
40Nucleotide excision repair_Homo sapiens_hsa034201.19178894
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09757837
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08861961
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07461996
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06953305
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.03889010
46Fanconi anemia pathway_Homo sapiens_hsa034600.99929405
47Purine metabolism_Homo sapiens_hsa002300.99260709
48Phototransduction_Homo sapiens_hsa047440.97438989
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96275257
50Base excision repair_Homo sapiens_hsa034100.90110434
51Cardiac muscle contraction_Homo sapiens_hsa042600.89056335
52Nitrogen metabolism_Homo sapiens_hsa009100.88939677
53Measles_Homo sapiens_hsa051620.87040020
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85520159
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73726356
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.72251197
57Butanoate metabolism_Homo sapiens_hsa006500.71468399
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70726523
59Selenocompound metabolism_Homo sapiens_hsa004500.70099367
60Peroxisome_Homo sapiens_hsa041460.70061328
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69398020
62Caffeine metabolism_Homo sapiens_hsa002320.68484612
63Linoleic acid metabolism_Homo sapiens_hsa005910.68011306
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64154320
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62702889
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.62514616
67Pyruvate metabolism_Homo sapiens_hsa006200.57118148
68Regulation of autophagy_Homo sapiens_hsa041400.55683244
69Metabolic pathways_Homo sapiens_hsa011000.54680465
70Retinol metabolism_Homo sapiens_hsa008300.52355332
71Viral myocarditis_Homo sapiens_hsa054160.51778204
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51640034
73Systemic lupus erythematosus_Homo sapiens_hsa053220.51560621
74Sulfur relay system_Homo sapiens_hsa041220.48829569
75Olfactory transduction_Homo sapiens_hsa047400.46362248
76Chemical carcinogenesis_Homo sapiens_hsa052040.45100853
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44048489
78Glutathione metabolism_Homo sapiens_hsa004800.42281953
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40298977
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40226336
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40038556
82Tryptophan metabolism_Homo sapiens_hsa003800.38973914
83mRNA surveillance pathway_Homo sapiens_hsa030150.37522810
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34695794
85Malaria_Homo sapiens_hsa051440.34190398
86Epstein-Barr virus infection_Homo sapiens_hsa051690.34108786
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33440334
88Arginine biosynthesis_Homo sapiens_hsa002200.30802477
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.30353719
90Arachidonic acid metabolism_Homo sapiens_hsa005900.29886284
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29426618
92Biosynthesis of amino acids_Homo sapiens_hsa012300.28228136
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.28173693
94Morphine addiction_Homo sapiens_hsa050320.27812570
95Steroid biosynthesis_Homo sapiens_hsa001000.27778040
96Vitamin B6 metabolism_Homo sapiens_hsa007500.26080005
97Shigellosis_Homo sapiens_hsa051310.25100673
98Folate biosynthesis_Homo sapiens_hsa007900.24850846
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24194100
100Nicotine addiction_Homo sapiens_hsa050330.23120427

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