

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 7.17032388 |
| 2 | cytidine metabolic process (GO:0046087) | 7.05454299 |
| 3 | cytidine catabolic process (GO:0006216) | 7.05454299 |
| 4 | cytidine deamination (GO:0009972) | 7.05454299 |
| 5 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 6.26459661 |
| 6 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 5.92952440 |
| 7 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 5.34224687 |
| 8 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 5.34224687 |
| 9 | proteasome assembly (GO:0043248) | 5.02758759 |
| 10 | regulation of regulatory T cell differentiation (GO:0045589) | 4.10409861 |
| 11 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.97633337 |
| 12 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.90739502 |
| 13 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.85193653 |
| 14 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.75702117 |
| 15 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.74969546 |
| 16 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.74969546 |
| 17 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.74969546 |
| 18 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.74779709 |
| 19 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.74779709 |
| 20 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.73305632 |
| 21 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.65293398 |
| 22 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 3.61563945 |
| 23 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.60051942 |
| 24 | positive regulation of interleukin-17 production (GO:0032740) | 3.54268602 |
| 25 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.54222057 |
| 26 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.54222057 |
| 27 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 3.53196793 |
| 28 | negative regulation of ligase activity (GO:0051352) | 3.51039894 |
| 29 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.51039894 |
| 30 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.49421308 |
| 31 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.49079698 |
| 32 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.45266743 |
| 33 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.43179722 |
| 34 | ATP synthesis coupled proton transport (GO:0015986) | 3.43179722 |
| 35 | regulation of chronic inflammatory response (GO:0002676) | 3.42576103 |
| 36 | pseudouridine synthesis (GO:0001522) | 3.41955868 |
| 37 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.32343535 |
| 38 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.32018911 |
| 39 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.27743115 |
| 40 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.25540080 |
| 41 | adenosine metabolic process (GO:0046085) | 3.24862732 |
| 42 | rRNA modification (GO:0000154) | 3.22522721 |
| 43 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.21037235 |
| 44 | positive regulation of interleukin-8 secretion (GO:2000484) | 3.20811566 |
| 45 | cytolysis (GO:0019835) | 3.15829259 |
| 46 | negative regulation of T cell apoptotic process (GO:0070233) | 3.14993539 |
| 47 | pyrimidine nucleoside catabolic process (GO:0046135) | 3.13326812 |
| 48 | DNA ligation (GO:0006266) | 3.10512056 |
| 49 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.10423037 |
| 50 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.09878547 |
| 51 | positive regulation of cell cycle arrest (GO:0071158) | 3.01383206 |
| 52 | positive regulation of B cell differentiation (GO:0045579) | 3.00333511 |
| 53 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 2.99700633 |
| 54 | positive regulation of ligase activity (GO:0051351) | 2.98441459 |
| 55 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 2.97688291 |
| 56 | regulation of natural killer cell mediated immunity (GO:0002715) | 2.97688291 |
| 57 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.97095498 |
| 58 | protein complex biogenesis (GO:0070271) | 2.96940273 |
| 59 | respiratory electron transport chain (GO:0022904) | 2.95116540 |
| 60 | tRNA processing (GO:0008033) | 2.95103287 |
| 61 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 2.90978201 |
| 62 | DNA double-strand break processing (GO:0000729) | 2.90840172 |
| 63 | electron transport chain (GO:0022900) | 2.90595487 |
| 64 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.89572849 |
| 65 | mitochondrial RNA metabolic process (GO:0000959) | 2.87311010 |
| 66 | pyrimidine ribonucleoside metabolic process (GO:0046131) | 2.87019292 |
| 67 | rRNA methylation (GO:0031167) | 2.86918485 |
| 68 | positive regulation of cell killing (GO:0031343) | 2.85904944 |
| 69 | negative regulation of lymphocyte apoptotic process (GO:0070229) | 2.85532097 |
| 70 | positive regulation of DNA recombination (GO:0045911) | 2.84606123 |
| 71 | T cell migration (GO:0072678) | 2.78803340 |
| 72 | platelet dense granule organization (GO:0060155) | 2.78137893 |
| 73 | protein-cofactor linkage (GO:0018065) | 2.77056952 |
| 74 | regulation of immunoglobulin secretion (GO:0051023) | 2.76547317 |
| 75 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.75337530 |
| 76 | regulation of cellular amine metabolic process (GO:0033238) | 2.74419469 |
| 77 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.72628323 |
| 78 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.72565223 |
| 79 | protein neddylation (GO:0045116) | 2.71776516 |
| 80 | regulation of activation of Janus kinase activity (GO:0010533) | 2.71689601 |
| 81 | positive regulation of T cell migration (GO:2000406) | 2.71459536 |
| 82 | maturation of 5.8S rRNA (GO:0000460) | 2.71389727 |
| 83 | positive regulation of defense response to virus by host (GO:0002230) | 2.71077142 |
| 84 | ribosome biogenesis (GO:0042254) | 2.70576638 |
| 85 | regulation of cell cycle arrest (GO:0071156) | 2.69551525 |
| 86 | negative regulation by host of viral transcription (GO:0043922) | 2.68589576 |
| 87 | DNA dealkylation (GO:0035510) | 2.68451440 |
| 88 | regulation of cell killing (GO:0031341) | 2.66731998 |
| 89 | protein targeting to mitochondrion (GO:0006626) | 2.66385441 |
| 90 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.65000036 |
| 91 | regulation of T cell mediated cytotoxicity (GO:0001914) | 2.64301724 |
| 92 | positive regulation of isotype switching (GO:0045830) | 2.63932797 |
| 93 | positive T cell selection (GO:0043368) | 2.63819002 |
| 94 | positive regulation of lymphocyte migration (GO:2000403) | 2.62780892 |
| 95 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.62647908 |
| 96 | DNA demethylation (GO:0080111) | 2.62446652 |
| 97 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.62050257 |
| 98 | chaperone-mediated protein transport (GO:0072321) | 2.62023262 |
| 99 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.60987700 |
| 100 | purine nucleotide salvage (GO:0032261) | 2.59923259 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 5.78828908 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.08109528 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.23223501 |
| 4 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 4.01962132 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.68227902 |
| 6 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.51332726 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.33064229 |
| 8 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.10384937 |
| 9 | VDR_22108803_ChIP-Seq_LS180_Human | 2.69069368 |
| 10 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.68534405 |
| 11 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.62344826 |
| 12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.60180011 |
| 13 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.47617303 |
| 14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.44435212 |
| 15 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.40107788 |
| 16 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.33046470 |
| 17 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.31428121 |
| 18 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.27433700 |
| 19 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.26828346 |
| 20 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.23050337 |
| 21 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.13223736 |
| 22 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.12100843 |
| 23 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.10952037 |
| 24 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.10795069 |
| 25 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.02675782 |
| 26 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.92586222 |
| 27 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.81224229 |
| 28 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.76720068 |
| 29 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.74460552 |
| 30 | MYB_26560356_Chip-Seq_TH2_Human | 1.64981022 |
| 31 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.60840939 |
| 32 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.60578516 |
| 33 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.58358621 |
| 34 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.58155938 |
| 35 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.58100147 |
| 36 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.55357547 |
| 37 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.54271727 |
| 38 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.51187382 |
| 39 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.50952286 |
| 40 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.50191645 |
| 41 | GATA3_26560356_Chip-Seq_TH2_Human | 1.48071936 |
| 42 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.46856437 |
| 43 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.43117421 |
| 44 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.39627771 |
| 45 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.38458703 |
| 46 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.37937808 |
| 47 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.36859571 |
| 48 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.36329912 |
| 49 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.36032593 |
| 50 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.33936775 |
| 51 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.33628410 |
| 52 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.32801151 |
| 53 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.30872447 |
| 54 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.29376121 |
| 55 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.26213998 |
| 56 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.25839697 |
| 57 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.23147984 |
| 58 | EWS_26573619_Chip-Seq_HEK293_Human | 1.20966071 |
| 59 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.19665481 |
| 60 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.15468974 |
| 61 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.14951463 |
| 62 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.11793593 |
| 63 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.08924934 |
| 64 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.06704326 |
| 65 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.06704326 |
| 66 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.04788074 |
| 67 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.03964675 |
| 68 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.02989017 |
| 69 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.00208379 |
| 70 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.00208379 |
| 71 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.99181796 |
| 72 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.97848307 |
| 73 | AR_20517297_ChIP-Seq_VCAP_Human | 0.97708556 |
| 74 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.97648171 |
| 75 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.97081790 |
| 76 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.96472423 |
| 77 | NCOR_22424771_ChIP-Seq_293T_Human | 0.96276122 |
| 78 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.95401685 |
| 79 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.94866711 |
| 80 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.94259056 |
| 81 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.93873413 |
| 82 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.93553189 |
| 83 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.93483686 |
| 84 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.93197959 |
| 85 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.91699026 |
| 86 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.91546817 |
| 87 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 0.90690420 |
| 88 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.90015588 |
| 89 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.88826908 |
| 90 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.88612832 |
| 91 | MYB_26560356_Chip-Seq_TH1_Human | 0.88295205 |
| 92 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.87312425 |
| 93 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.87186814 |
| 94 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.85059292 |
| 95 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.84965414 |
| 96 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.84622115 |
| 97 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.84610441 |
| 98 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.84058792 |
| 99 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.83697547 |
| 100 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.83222375 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005671_abnormal_response_to | 4.74842761 |
| 2 | MP0004147_increased_porphyrin_level | 3.22162008 |
| 3 | MP0001835_abnormal_antigen_presentation | 3.21065712 |
| 4 | MP0009333_abnormal_splenocyte_physiolog | 2.88723756 |
| 5 | MP0002102_abnormal_ear_morphology | 2.87988368 |
| 6 | MP0009785_altered_susceptibility_to | 2.84909296 |
| 7 | MP0003786_premature_aging | 2.78910246 |
| 8 | MP0003763_abnormal_thymus_physiology | 2.54647581 |
| 9 | MP0003693_abnormal_embryo_hatching | 2.24871627 |
| 10 | MP0005000_abnormal_immune_tolerance | 2.24356588 |
| 11 | MP0005646_abnormal_pituitary_gland | 1.97623768 |
| 12 | MP0006072_abnormal_retinal_apoptosis | 1.96725914 |
| 13 | MP0002736_abnormal_nociception_after | 1.96581593 |
| 14 | MP0005360_urolithiasis | 1.96476708 |
| 15 | MP0004885_abnormal_endolymph | 1.95948514 |
| 16 | MP0008877_abnormal_DNA_methylation | 1.91312049 |
| 17 | MP0001919_abnormal_reproductive_system | 1.89560169 |
| 18 | MP0001800_abnormal_humoral_immune | 1.88078400 |
| 19 | MP0002148_abnormal_hypersensitivity_rea | 1.85957393 |
| 20 | MP0008872_abnormal_physiological_respon | 1.82451102 |
| 21 | MP0003866_abnormal_defecation | 1.81136350 |
| 22 | MP0001873_stomach_inflammation | 1.79569473 |
| 23 | MP0001853_heart_inflammation | 1.73072186 |
| 24 | MP0005075_abnormal_melanosome_morpholog | 1.69389000 |
| 25 | MP0006082_CNS_inflammation | 1.66513770 |
| 26 | MP0002420_abnormal_adaptive_immunity | 1.64250238 |
| 27 | MP0002723_abnormal_immune_serum | 1.64008440 |
| 28 | MP0008058_abnormal_DNA_repair | 1.63279766 |
| 29 | MP0003878_abnormal_ear_physiology | 1.59210866 |
| 30 | MP0005377_hearing/vestibular/ear_phenot | 1.59210866 |
| 31 | MP0005387_immune_system_phenotype | 1.57441412 |
| 32 | MP0001790_abnormal_immune_system | 1.57441412 |
| 33 | MP0003646_muscle_fatigue | 1.56766900 |
| 34 | MP0008875_abnormal_xenobiotic_pharmacok | 1.55131014 |
| 35 | MP0001819_abnormal_immune_cell | 1.55075908 |
| 36 | MP0005025_abnormal_response_to | 1.53660318 |
| 37 | MP0008995_early_reproductive_senescence | 1.52095594 |
| 38 | MP0005389_reproductive_system_phenotype | 1.50200536 |
| 39 | MP0000372_irregular_coat_pigmentation | 1.49312503 |
| 40 | MP0002166_altered_tumor_susceptibility | 1.48793729 |
| 41 | MP0001968_abnormal_touch/_nociception | 1.48571927 |
| 42 | MP0010094_abnormal_chromosome_stability | 1.40986466 |
| 43 | MP0001661_extended_life_span | 1.40473150 |
| 44 | MP0003045_fibrosis | 1.40133769 |
| 45 | MP0005645_abnormal_hypothalamus_physiol | 1.39483164 |
| 46 | MP0005551_abnormal_eye_electrophysiolog | 1.38176953 |
| 47 | MP0002006_tumorigenesis | 1.37840408 |
| 48 | MP0000685_abnormal_immune_system | 1.37483350 |
| 49 | MP0000703_abnormal_thymus_morphology | 1.34894358 |
| 50 | MP0002398_abnormal_bone_marrow | 1.34870136 |
| 51 | MP0002452_abnormal_antigen_presenting | 1.31200922 |
| 52 | MP0000716_abnormal_immune_system | 1.28536459 |
| 53 | MP0000689_abnormal_spleen_morphology | 1.28210503 |
| 54 | MP0008057_abnormal_DNA_replication | 1.27825573 |
| 55 | MP0004957_abnormal_blastocyst_morpholog | 1.25700820 |
| 56 | MP0003806_abnormal_nucleotide_metabolis | 1.20521144 |
| 57 | MP0002722_abnormal_immune_system | 1.19906433 |
| 58 | MP0002138_abnormal_hepatobiliary_system | 1.17365004 |
| 59 | MP0006036_abnormal_mitochondrial_physio | 1.16463962 |
| 60 | MP0010155_abnormal_intestine_physiology | 1.15115603 |
| 61 | MP0001845_abnormal_inflammatory_respons | 1.14168768 |
| 62 | MP0002405_respiratory_system_inflammati | 1.13941929 |
| 63 | MP0002837_dystrophic_cardiac_calcinosis | 1.12861995 |
| 64 | MP0005253_abnormal_eye_physiology | 1.11685034 |
| 65 | MP0003724_increased_susceptibility_to | 1.11653245 |
| 66 | MP0003448_altered_tumor_morphology | 1.09236815 |
| 67 | MP0002429_abnormal_blood_cell | 1.07898092 |
| 68 | MP0001764_abnormal_homeostasis | 1.03977011 |
| 69 | MP0003195_calcinosis | 1.01659481 |
| 70 | MP0005410_abnormal_fertilization | 1.01521372 |
| 71 | MP0001905_abnormal_dopamine_level | 1.01304366 |
| 72 | MP0008789_abnormal_olfactory_epithelium | 1.00350815 |
| 73 | MP0003880_abnormal_central_pattern | 0.99760141 |
| 74 | MP0002938_white_spotting | 0.98603564 |
| 75 | MP0005332_abnormal_amino_acid | 0.95384606 |
| 76 | MP0002163_abnormal_gland_morphology | 0.95075795 |
| 77 | MP0005636_abnormal_mineral_homeostasis | 0.94807968 |
| 78 | MP0009764_decreased_sensitivity_to | 0.94688981 |
| 79 | MP0002019_abnormal_tumor_incidence | 0.94010687 |
| 80 | MP0002876_abnormal_thyroid_physiology | 0.92842799 |
| 81 | MP0002160_abnormal_reproductive_system | 0.91723185 |
| 82 | MP0000465_gastrointestinal_hemorrhage | 0.90577391 |
| 83 | MP0004145_abnormal_muscle_electrophysio | 0.88568676 |
| 84 | MP0001119_abnormal_female_reproductive | 0.87022971 |
| 85 | MP0005084_abnormal_gallbladder_morpholo | 0.85614503 |
| 86 | MP0006276_abnormal_autonomic_nervous | 0.85130122 |
| 87 | MP0002095_abnormal_skin_pigmentation | 0.84875911 |
| 88 | MP0008469_abnormal_protein_level | 0.83720871 |
| 89 | MP0002210_abnormal_sex_determination | 0.82528557 |
| 90 | MP0009643_abnormal_urine_homeostasis | 0.81656876 |
| 91 | MP0008873_increased_physiological_sensi | 0.80347738 |
| 92 | MP0001485_abnormal_pinna_reflex | 0.79815304 |
| 93 | MP0001348_abnormal_lacrimal_gland | 0.78735367 |
| 94 | MP0003111_abnormal_nucleus_morphology | 0.78227105 |
| 95 | MP0004742_abnormal_vestibular_system | 0.78065534 |
| 96 | MP0002735_abnormal_chemical_nociception | 0.77788887 |
| 97 | MP0001929_abnormal_gametogenesis | 0.76296391 |
| 98 | MP0008007_abnormal_cellular_replicative | 0.74480758 |
| 99 | MP0000653_abnormal_sex_gland | 0.72975146 |
| 100 | MP0001986_abnormal_taste_sensitivity | 0.72768656 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Aplastic anemia (HP:0001915) | 4.83611257 |
| 2 | IgG deficiency (HP:0004315) | 4.39055863 |
| 3 | Hyperalaninemia (HP:0003348) | 4.19010433 |
| 4 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 4.19010433 |
| 5 | Abnormality of alanine metabolism (HP:0010916) | 4.19010433 |
| 6 | Acute necrotizing encephalopathy (HP:0006965) | 4.13047115 |
| 7 | Mitochondrial inheritance (HP:0001427) | 3.80029129 |
| 8 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.76574579 |
| 9 | Constricted visual fields (HP:0001133) | 3.75066060 |
| 10 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.68605571 |
| 11 | Acute encephalopathy (HP:0006846) | 3.60697173 |
| 12 | Hypoproteinemia (HP:0003075) | 3.50700904 |
| 13 | Stomatitis (HP:0010280) | 3.50423787 |
| 14 | Increased CSF lactate (HP:0002490) | 3.38721314 |
| 15 | Severe combined immunodeficiency (HP:0004430) | 3.32899604 |
| 16 | Cerebral edema (HP:0002181) | 3.30558734 |
| 17 | Progressive macrocephaly (HP:0004481) | 3.30045199 |
| 18 | Increased hepatocellular lipid droplets (HP:0006565) | 3.20966171 |
| 19 | T lymphocytopenia (HP:0005403) | 3.19547549 |
| 20 | Hepatocellular necrosis (HP:0001404) | 3.18801191 |
| 21 | 3-Methylglutaconic aciduria (HP:0003535) | 3.17485420 |
| 22 | Lipid accumulation in hepatocytes (HP:0006561) | 3.12221899 |
| 23 | B lymphocytopenia (HP:0010976) | 3.11108852 |
| 24 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.09651324 |
| 25 | Generalized aminoaciduria (HP:0002909) | 2.98848017 |
| 26 | Increased serum lactate (HP:0002151) | 2.97957438 |
| 27 | Increased IgM level (HP:0003496) | 2.93987899 |
| 28 | Abnormality of T cell number (HP:0011839) | 2.92115438 |
| 29 | Hepatic necrosis (HP:0002605) | 2.86361133 |
| 30 | Abnormality of B cell number (HP:0010975) | 2.82708875 |
| 31 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.82576494 |
| 32 | Pancytopenia (HP:0001876) | 2.79183519 |
| 33 | Renal Fanconi syndrome (HP:0001994) | 2.68966219 |
| 34 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.67839408 |
| 35 | Combined immunodeficiency (HP:0005387) | 2.66956791 |
| 36 | Abnormality of the prostate (HP:0008775) | 2.64390004 |
| 37 | Increased intramyocellular lipid droplets (HP:0012240) | 2.63381881 |
| 38 | Lactic acidosis (HP:0003128) | 2.61406265 |
| 39 | Thyroiditis (HP:0100646) | 2.58817684 |
| 40 | Chronic diarrhea (HP:0002028) | 2.55450051 |
| 41 | Abnormality of T cells (HP:0002843) | 2.52533379 |
| 42 | Abnormality of eosinophils (HP:0001879) | 2.50888803 |
| 43 | Optic disc pallor (HP:0000543) | 2.50246572 |
| 44 | Abnormality of serum amino acid levels (HP:0003112) | 2.48383192 |
| 45 | Lethargy (HP:0001254) | 2.42716388 |
| 46 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.36133519 |
| 47 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.36133519 |
| 48 | Oral leukoplakia (HP:0002745) | 2.34495236 |
| 49 | Pancreatic cysts (HP:0001737) | 2.32819669 |
| 50 | Increased serum pyruvate (HP:0003542) | 2.31321337 |
| 51 | Hyperglycinemia (HP:0002154) | 2.29321504 |
| 52 | Exertional dyspnea (HP:0002875) | 2.26899371 |
| 53 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.26862934 |
| 54 | Increased muscle lipid content (HP:0009058) | 2.26463569 |
| 55 | Exercise intolerance (HP:0003546) | 2.24142794 |
| 56 | Attenuation of retinal blood vessels (HP:0007843) | 2.18561704 |
| 57 | Methylmalonic acidemia (HP:0002912) | 2.18519414 |
| 58 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.17685547 |
| 59 | Methylmalonic aciduria (HP:0012120) | 2.16231872 |
| 60 | Autoimmune hemolytic anemia (HP:0001890) | 2.10835390 |
| 61 | Hypoplasia of the thymus (HP:0000778) | 2.03729147 |
| 62 | Congenital stationary night blindness (HP:0007642) | 2.03638998 |
| 63 | Poor speech (HP:0002465) | 2.03058434 |
| 64 | IgM deficiency (HP:0002850) | 2.00492847 |
| 65 | Dicarboxylic aciduria (HP:0003215) | 1.95923725 |
| 66 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.95923725 |
| 67 | Neutropenia (HP:0001875) | 1.92708784 |
| 68 | Congenital, generalized hypertrichosis (HP:0004540) | 1.89703196 |
| 69 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.89378221 |
| 70 | Eosinophilia (HP:0001880) | 1.88708876 |
| 71 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.88023156 |
| 72 | Abnormality of glycine metabolism (HP:0010895) | 1.88023156 |
| 73 | Abnormal albumin level (HP:0012116) | 1.86934203 |
| 74 | Hypoalbuminemia (HP:0003073) | 1.86934203 |
| 75 | Cerebral hypomyelination (HP:0006808) | 1.86924336 |
| 76 | Respiratory failure (HP:0002878) | 1.85503970 |
| 77 | Leukodystrophy (HP:0002415) | 1.85379979 |
| 78 | True hermaphroditism (HP:0010459) | 1.85265691 |
| 79 | Pancreatic fibrosis (HP:0100732) | 1.82206801 |
| 80 | Glycosuria (HP:0003076) | 1.82010601 |
| 81 | Abnormality of urine glucose concentration (HP:0011016) | 1.82010601 |
| 82 | Abnormality of T cell physiology (HP:0011840) | 1.81974535 |
| 83 | Meckel diverticulum (HP:0002245) | 1.80951709 |
| 84 | Abnormality of the ileum (HP:0001549) | 1.79576403 |
| 85 | Panhypogammaglobulinemia (HP:0003139) | 1.76493518 |
| 86 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.76274517 |
| 87 | Abnormality of glycolysis (HP:0004366) | 1.76081281 |
| 88 | Lymphoma (HP:0002665) | 1.76057893 |
| 89 | Type I transferrin isoform profile (HP:0003642) | 1.75365336 |
| 90 | Microvesicular hepatic steatosis (HP:0001414) | 1.75185119 |
| 91 | Lymphopenia (HP:0001888) | 1.75175159 |
| 92 | Pendular nystagmus (HP:0012043) | 1.74730944 |
| 93 | Abnormality of the renal collecting system (HP:0004742) | 1.71708575 |
| 94 | Hypoplasia of the uterus (HP:0000013) | 1.71238908 |
| 95 | Congenital sensorineural hearing impairment (HP:0008527) | 1.69953477 |
| 96 | Molar tooth sign on MRI (HP:0002419) | 1.69940157 |
| 97 | Abnormality of midbrain morphology (HP:0002418) | 1.69940157 |
| 98 | Carpal bone hypoplasia (HP:0001498) | 1.68889365 |
| 99 | Absent thumb (HP:0009777) | 1.67195922 |
| 100 | Abolished electroretinogram (ERG) (HP:0000550) | 1.66879865 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 4.60509590 |
| 2 | KDR | 4.37262734 |
| 3 | VRK2 | 3.68875981 |
| 4 | TESK2 | 3.02930547 |
| 5 | BUB1 | 2.99209962 |
| 6 | EIF2AK3 | 2.96214946 |
| 7 | BCKDK | 2.91277558 |
| 8 | MAP3K9 | 2.74677684 |
| 9 | MST4 | 2.43749139 |
| 10 | EIF2AK1 | 2.42562652 |
| 11 | MAP4K2 | 2.23635388 |
| 12 | ZAK | 2.21743252 |
| 13 | NUAK1 | 2.14874699 |
| 14 | MAP4K1 | 1.92964000 |
| 15 | SRPK1 | 1.69724952 |
| 16 | VRK1 | 1.61601197 |
| 17 | ADRBK2 | 1.60411073 |
| 18 | ITK | 1.60395682 |
| 19 | NME1 | 1.53805731 |
| 20 | TAF1 | 1.52244415 |
| 21 | TLK1 | 1.50754226 |
| 22 | GRK1 | 1.50212635 |
| 23 | TRIM28 | 1.46901951 |
| 24 | GRK6 | 1.41621740 |
| 25 | TEC | 1.38828152 |
| 26 | SCYL2 | 1.31290354 |
| 27 | TIE1 | 1.30093730 |
| 28 | MUSK | 1.27851041 |
| 29 | FES | 1.26947205 |
| 30 | PAK4 | 1.14174831 |
| 31 | BMPR2 | 1.10517705 |
| 32 | TESK1 | 1.05200136 |
| 33 | TSSK6 | 1.02485874 |
| 34 | DAPK1 | 0.99941410 |
| 35 | STK16 | 0.99263332 |
| 36 | PLK4 | 0.99029528 |
| 37 | NEK1 | 0.96926385 |
| 38 | LIMK1 | 0.95525043 |
| 39 | PBK | 0.93275941 |
| 40 | CSNK1G3 | 0.92928652 |
| 41 | IKBKB | 0.89836921 |
| 42 | PIK3CG | 0.88181696 |
| 43 | INSRR | 0.85583079 |
| 44 | ACVR1B | 0.81117288 |
| 45 | EIF2AK2 | 0.80399299 |
| 46 | WNK3 | 0.79641325 |
| 47 | PLK3 | 0.76918350 |
| 48 | BMPR1B | 0.73789772 |
| 49 | CSNK1G1 | 0.72934476 |
| 50 | CCNB1 | 0.70495900 |
| 51 | SYK | 0.69632917 |
| 52 | ATR | 0.67990473 |
| 53 | LCK | 0.67438853 |
| 54 | PASK | 0.67026192 |
| 55 | AURKA | 0.66233231 |
| 56 | MYLK | 0.65509590 |
| 57 | PLK1 | 0.62751078 |
| 58 | CDC7 | 0.61846286 |
| 59 | CSK | 0.61337967 |
| 60 | PLK2 | 0.60715508 |
| 61 | RAF1 | 0.60227383 |
| 62 | CSNK1A1L | 0.59255817 |
| 63 | PAK3 | 0.55954379 |
| 64 | AURKB | 0.55138874 |
| 65 | MAP3K12 | 0.55060816 |
| 66 | CSNK1G2 | 0.54270045 |
| 67 | FRK | 0.53881530 |
| 68 | WNK4 | 0.53629094 |
| 69 | JAK3 | 0.53281377 |
| 70 | CSNK1A1 | 0.53094663 |
| 71 | PRKCQ | 0.52704334 |
| 72 | CDK9 | 0.51426448 |
| 73 | PAK1 | 0.50194405 |
| 74 | MAP2K7 | 0.49479318 |
| 75 | TNK2 | 0.48935362 |
| 76 | LYN | 0.48879533 |
| 77 | CSNK2A1 | 0.47177493 |
| 78 | BTK | 0.46225786 |
| 79 | TAOK3 | 0.45350162 |
| 80 | RPS6KA4 | 0.45167163 |
| 81 | CSNK2A2 | 0.44201428 |
| 82 | STK39 | 0.42819104 |
| 83 | IGF1R | 0.42374511 |
| 84 | OXSR1 | 0.42368815 |
| 85 | BCR | 0.41956480 |
| 86 | PINK1 | 0.41321700 |
| 87 | MATK | 0.39583670 |
| 88 | ADRBK1 | 0.37693277 |
| 89 | ERBB3 | 0.37613582 |
| 90 | CAMKK2 | 0.36493511 |
| 91 | RPS6KA5 | 0.36129607 |
| 92 | DYRK2 | 0.35566449 |
| 93 | GRK5 | 0.32778466 |
| 94 | KIT | 0.31217483 |
| 95 | PIM2 | 0.30590830 |
| 96 | TYRO3 | 0.29870466 |
| 97 | MAPKAPK5 | 0.29272871 |
| 98 | INSR | 0.28743850 |
| 99 | MKNK1 | 0.28192686 |
| 100 | NEK9 | 0.27602757 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.31574457 |
| 2 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.75415699 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.22642139 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 2.66410332 |
| 5 | Protein export_Homo sapiens_hsa03060 | 2.57643097 |
| 6 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.48561356 |
| 7 | Allograft rejection_Homo sapiens_hsa05330 | 2.38432249 |
| 8 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.30516139 |
| 9 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.26597827 |
| 10 | RNA polymerase_Homo sapiens_hsa03020 | 2.25987920 |
| 11 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.09406841 |
| 12 | Ribosome_Homo sapiens_hsa03010 | 1.86682550 |
| 13 | DNA replication_Homo sapiens_hsa03030 | 1.81610517 |
| 14 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.77732116 |
| 15 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.76149175 |
| 16 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.75948004 |
| 17 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.67952206 |
| 18 | Asthma_Homo sapiens_hsa05310 | 1.66834847 |
| 19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.64917273 |
| 20 | Homologous recombination_Homo sapiens_hsa03440 | 1.63359089 |
| 21 | Huntingtons disease_Homo sapiens_hsa05016 | 1.62650899 |
| 22 | Mismatch repair_Homo sapiens_hsa03430 | 1.57901740 |
| 23 | Alzheimers disease_Homo sapiens_hsa05010 | 1.56816371 |
| 24 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.54707309 |
| 25 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.53053544 |
| 26 | Spliceosome_Homo sapiens_hsa03040 | 1.51348945 |
| 27 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.48810098 |
| 28 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.44645916 |
| 29 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.42351005 |
| 30 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.39254969 |
| 31 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.37537484 |
| 32 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.36748012 |
| 33 | RNA transport_Homo sapiens_hsa03013 | 1.35008917 |
| 34 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.32081086 |
| 35 | RNA degradation_Homo sapiens_hsa03018 | 1.30731231 |
| 36 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.29648893 |
| 37 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.27477632 |
| 38 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.23758303 |
| 39 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.22652654 |
| 40 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.19178894 |
| 41 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.09757837 |
| 42 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.08861961 |
| 43 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.07461996 |
| 44 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.06953305 |
| 45 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.03889010 |
| 46 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.99929405 |
| 47 | Purine metabolism_Homo sapiens_hsa00230 | 0.99260709 |
| 48 | Phototransduction_Homo sapiens_hsa04744 | 0.97438989 |
| 49 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.96275257 |
| 50 | Base excision repair_Homo sapiens_hsa03410 | 0.90110434 |
| 51 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.89056335 |
| 52 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.88939677 |
| 53 | Measles_Homo sapiens_hsa05162 | 0.87040020 |
| 54 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.85520159 |
| 55 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.73726356 |
| 56 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.72251197 |
| 57 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.71468399 |
| 58 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.70726523 |
| 59 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.70099367 |
| 60 | Peroxisome_Homo sapiens_hsa04146 | 0.70061328 |
| 61 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.69398020 |
| 62 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.68484612 |
| 63 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.68011306 |
| 64 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.64154320 |
| 65 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.62702889 |
| 66 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.62514616 |
| 67 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.57118148 |
| 68 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.55683244 |
| 69 | Metabolic pathways_Homo sapiens_hsa01100 | 0.54680465 |
| 70 | Retinol metabolism_Homo sapiens_hsa00830 | 0.52355332 |
| 71 | Viral myocarditis_Homo sapiens_hsa05416 | 0.51778204 |
| 72 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.51640034 |
| 73 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.51560621 |
| 74 | Sulfur relay system_Homo sapiens_hsa04122 | 0.48829569 |
| 75 | Olfactory transduction_Homo sapiens_hsa04740 | 0.46362248 |
| 76 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.45100853 |
| 77 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.44048489 |
| 78 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.42281953 |
| 79 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.40298977 |
| 80 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.40226336 |
| 81 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.40038556 |
| 82 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.38973914 |
| 83 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.37522810 |
| 84 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.34695794 |
| 85 | Malaria_Homo sapiens_hsa05144 | 0.34190398 |
| 86 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.34108786 |
| 87 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.33440334 |
| 88 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.30802477 |
| 89 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.30353719 |
| 90 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.29886284 |
| 91 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.29426618 |
| 92 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.28228136 |
| 93 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.28173693 |
| 94 | Morphine addiction_Homo sapiens_hsa05032 | 0.27812570 |
| 95 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.27778040 |
| 96 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.26080005 |
| 97 | Shigellosis_Homo sapiens_hsa05131 | 0.25100673 |
| 98 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.24850846 |
| 99 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.24194100 |
| 100 | Nicotine addiction_Homo sapiens_hsa05033 | 0.23120427 |

