RANP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of synapse structural plasticity (GO:0051823)9.32478662
2pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)6.89425122
3UMP metabolic process (GO:0046049)6.89425122
4pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)6.89425122
5UMP biosynthetic process (GO:0006222)6.89425122
6acrosome assembly (GO:0001675)5.92897571
7presynaptic membrane assembly (GO:0097105)5.75934149
8pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)5.74477762
9pyrimidine nucleoside monophosphate metabolic process (GO:0009129)5.22191305
10central nervous system projection neuron axonogenesis (GO:0021952)5.04443982
11positive regulation of amino acid transport (GO:0051957)4.79090696
12positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.60742577
13postsynaptic membrane organization (GO:0001941)4.59086202
14presynaptic membrane organization (GO:0097090)4.52818313
15regulation of feeding behavior (GO:0060259)4.34317147
16tachykinin receptor signaling pathway (GO:0007217)4.30173326
17glycosphingolipid biosynthetic process (GO:0006688)4.19979946
18atrial cardiac muscle cell action potential (GO:0086014)4.10877780
19central nervous system neuron axonogenesis (GO:0021955)4.00776733
20positive regulation of meiosis (GO:0045836)3.99160115
21regulation of glucokinase activity (GO:0033131)3.98480650
22regulation of hexokinase activity (GO:1903299)3.98480650
23regulation of DNA endoreduplication (GO:0032875)3.94519819
24pyrimidine nucleobase metabolic process (GO:0006206)3.93272239
25ganglion development (GO:0061548)3.89529118
26brain morphogenesis (GO:0048854)3.87778975
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.86388155
28negative regulation of synaptic transmission, GABAergic (GO:0032229)3.84075148
29protein polyglutamylation (GO:0018095)3.79748050
30sympathetic nervous system development (GO:0048485)3.78186354
31pyrimidine-containing compound catabolic process (GO:0072529)3.67906643
32positive regulation of meiotic cell cycle (GO:0051446)3.67339071
33positive regulation of oligodendrocyte differentiation (GO:0048714)3.66792000
34vocalization behavior (GO:0071625)3.65977969
35sialylation (GO:0097503)3.61085776
36facial nerve structural organization (GO:0021612)3.59778307
37microtubule nucleation (GO:0007020)3.56428256
38regulation of synapse organization (GO:0050807)3.53341104
39regulation of dendritic spine morphogenesis (GO:0061001)3.50140053
40pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.43617455
41retinal ganglion cell axon guidance (GO:0031290)3.40401016
42layer formation in cerebral cortex (GO:0021819)3.34344567
43olfactory bulb development (GO:0021772)3.31668060
44sarcoplasmic reticulum calcium ion transport (GO:0070296)3.30050351
45neuron cell-cell adhesion (GO:0007158)3.29704113
46regulation of male gonad development (GO:2000018)3.29457419
47pyrimidine ribonucleotide biosynthetic process (GO:0009220)3.28783720
48regulation of cardiac muscle cell contraction (GO:0086004)3.27781606
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.22567544
50response to methylmercury (GO:0051597)3.21891693
51axon extension (GO:0048675)3.21252881
52grooming behavior (GO:0007625)3.20521207
53centrosome duplication (GO:0051298)3.18521638
54positive regulation of gastrulation (GO:2000543)3.17973674
55cranial nerve structural organization (GO:0021604)3.15099940
56regulation of dendritic spine development (GO:0060998)3.14946496
57positive regulation of myoblast differentiation (GO:0045663)3.10548228
58cerebral cortex neuron differentiation (GO:0021895)3.10210140
59pyrimidine ribonucleotide metabolic process (GO:0009218)3.10001133
60regulation of synapse assembly (GO:0051963)3.05725051
61membrane invagination (GO:0010324)3.04770753
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04076772
63mitochondrial respiratory chain complex I assembly (GO:0032981)3.04076772
64NADH dehydrogenase complex assembly (GO:0010257)3.04076772
65positive regulation of embryonic development (GO:0040019)3.01745207
66positive regulation of potassium ion transmembrane transport (GO:1901381)3.00899157
67cranial nerve morphogenesis (GO:0021602)3.00782434
68proline transport (GO:0015824)2.98183774
69homocysteine metabolic process (GO:0050667)2.97655513
70regulation of cilium movement (GO:0003352)2.96143677
71pyrimidine nucleoside catabolic process (GO:0046135)2.90310545
72membrane disassembly (GO:0030397)2.89498060
73nuclear envelope disassembly (GO:0051081)2.89498060
74regulation of glutamate secretion (GO:0014048)2.88438928
75regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.85219194
76positive regulation of dendritic spine morphogenesis (GO:0061003)2.83322798
77regulation of actin filament-based movement (GO:1903115)2.82306064
78fatty acid elongation (GO:0030497)2.81704121
79pyrimidine nucleotide biosynthetic process (GO:0006221)2.81223776
80regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.78340533
81positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.77364879
82response to inactivity (GO:0014854)2.73387962
83nonmotile primary cilium assembly (GO:0035058)2.71005039
84phagocytosis, engulfment (GO:0006911)2.69964892
85regulation of gonadotropin secretion (GO:0032276)2.68839874
86barbed-end actin filament capping (GO:0051016)2.67757744
87response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.67218696
88negative chemotaxis (GO:0050919)2.64744221
89clathrin coat assembly (GO:0048268)2.63477277
90protein-cofactor linkage (GO:0018065)2.62019946
91positive regulation of amine transport (GO:0051954)2.61870469
92mitotic nuclear envelope disassembly (GO:0007077)2.60021050
93tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.58986224
94RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.58986224
95positive regulation of potassium ion transport (GO:0043268)2.57993998
96regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.57705171
97spinal cord development (GO:0021510)2.57039367
98neuron projection extension (GO:1990138)2.54016185
99pyrimidine nucleobase catabolic process (GO:0006208)14.9589810
100nucleobase catabolic process (GO:0046113)11.9581890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.48948862
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.04033907
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.39242291
4ZNF274_21170338_ChIP-Seq_K562_Hela3.32764878
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.31368199
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.05060480
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.91484762
8EWS_26573619_Chip-Seq_HEK293_Human2.70196769
9GBX2_23144817_ChIP-Seq_PC3_Human2.65572109
10PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.53553710
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.50548865
12FUS_26573619_Chip-Seq_HEK293_Human2.49986757
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47262204
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41868608
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.39704157
16P300_19829295_ChIP-Seq_ESCs_Human2.35826035
17E2F7_22180533_ChIP-Seq_HELA_Human2.29533790
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21768858
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21428733
20VDR_22108803_ChIP-Seq_LS180_Human2.16709544
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.09975594
22RNF2_27304074_Chip-Seq_NSC_Mouse2.03877968
23TAF15_26573619_Chip-Seq_HEK293_Human2.03341177
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01228943
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93972122
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.93776794
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.93507226
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87058165
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86793413
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.83750150
31IGF1R_20145208_ChIP-Seq_DFB_Human1.81658584
32SMAD4_21799915_ChIP-Seq_A2780_Human1.78553279
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.76417688
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.73770966
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72917746
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71497655
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70930605
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.65077178
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.63239629
40KDM2B_26808549_Chip-Seq_REH_Human1.62096999
41STAT3_23295773_ChIP-Seq_U87_Human1.55773098
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52901262
43TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52881734
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.52867746
45TP53_22573176_ChIP-Seq_HFKS_Human1.48818217
46TP53_18474530_ChIP-ChIP_U2OS_Human1.47846006
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46000705
48TCF4_22108803_ChIP-Seq_LS180_Human1.44976509
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44472904
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42218008
51REST_21632747_ChIP-Seq_MESCs_Mouse1.41896035
52TCF4_23295773_ChIP-Seq_U87_Human1.41678108
53AR_21909140_ChIP-Seq_LNCAP_Human1.40457891
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.35808840
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.35464929
56RUNX2_22187159_ChIP-Seq_PCA_Human1.33740179
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30360350
58CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.29416880
59KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26513708
60SOX9_26525672_Chip-Seq_HEART_Mouse1.26087648
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24950650
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.23946780
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23520542
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23229136
65GABP_17652178_ChIP-ChIP_JURKAT_Human1.22490365
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18647367
67LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15899318
68AR_25329375_ChIP-Seq_VCAP_Human1.15438647
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.15072053
70TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14930431
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13119219
72LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12656730
73JUN_21703547_ChIP-Seq_K562_Human1.12648040
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11395563
75ER_23166858_ChIP-Seq_MCF-7_Human1.11326125
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10146594
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10080764
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09825444
79REST_18959480_ChIP-ChIP_MESCs_Mouse1.06960163
80POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.06889128
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.06721878
82SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05595041
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.02924952
84SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01834466
85BCAT_22108803_ChIP-Seq_LS180_Human1.01506240
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00022553
87JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98667413
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98513800
89E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98027075
90KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97327584
91BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97292500
92NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97152175
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97152175
94SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96694214
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96406722
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96359552
97RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96127572
98EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96127572
99TCF4_18268006_ChIP-ChIP_LS174T_Human0.93823204
100EZH2_27304074_Chip-Seq_ESCs_Mouse0.93332213

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000516_abnormal_urinary_system4.19045465
2MP0005367_renal/urinary_system_phenotyp4.19045465
3MP0004859_abnormal_synaptic_plasticity3.25986239
4MP0006054_spinal_hemorrhage2.97389920
5MP0001486_abnormal_startle_reflex2.80609982
6MP0000749_muscle_degeneration2.80104326
7MP0001529_abnormal_vocalization2.78806650
8MP0003880_abnormal_central_pattern2.74829459
9MP0008872_abnormal_physiological_respon2.60214182
10MP0003656_abnormal_erythrocyte_physiolo2.24586540
11MP0000778_abnormal_nervous_system2.24091990
12MP0001177_atelectasis2.10109448
13MP0002736_abnormal_nociception_after2.08587997
14MP0002751_abnormal_autonomic_nervous2.02157277
15MP0001984_abnormal_olfaction1.91726408
16MP0000747_muscle_weakness1.90059567
17MP0004147_increased_porphyrin_level1.84961946
18MP0002234_abnormal_pharynx_morphology1.84321177
19MP0002184_abnormal_innervation1.83223515
20MP0005076_abnormal_cell_differentiation1.73188546
21MP0004145_abnormal_muscle_electrophysio1.70221513
22MP0003635_abnormal_synaptic_transmissio1.68385770
23MP0000049_abnormal_middle_ear1.64628161
24MP0005670_abnormal_white_adipose1.64319826
25MP0009745_abnormal_behavioral_response1.58285459
26MP0002063_abnormal_learning/memory/cond1.55837765
27MP0003137_abnormal_impulse_conducting1.55807005
28MP0002269_muscular_atrophy1.53559738
29MP0000751_myopathy1.50038130
30MP0000955_abnormal_spinal_cord1.47306545
31MP0002064_seizures1.43429488
32MP0002735_abnormal_chemical_nociception1.43273840
33MP0008057_abnormal_DNA_replication1.37649189
34MP0000733_abnormal_muscle_development1.34359345
35MP0004924_abnormal_behavior1.29854554
36MP0005386_behavior/neurological_phenoty1.29854554
37MP0002106_abnormal_muscle_physiology1.29206589
38MP0002734_abnormal_mechanical_nocicepti1.29097275
39MP0004043_abnormal_pH_regulation1.28267457
40MP0004270_analgesia1.28242566
41MP0001968_abnormal_touch/_nociception1.26264737
42MP0004811_abnormal_neuron_physiology1.24852045
43MP0006276_abnormal_autonomic_nervous1.24143243
44MP0010368_abnormal_lymphatic_system1.23260039
45MP0000534_abnormal_ureter_morphology1.21887099
46MP0008789_abnormal_olfactory_epithelium1.21870113
47MP0000759_abnormal_skeletal_muscle1.20644735
48MP0000647_abnormal_sebaceous_gland1.17688572
49MP0003136_yellow_coat_color1.14396636
50MP0004142_abnormal_muscle_tone1.13705836
51MP0005551_abnormal_eye_electrophysiolog1.11102870
52MP0004885_abnormal_endolymph1.08869630
53MP0002572_abnormal_emotion/affect_behav1.05440175
54MP0004215_abnormal_myocardial_fiber1.04860429
55MP0005646_abnormal_pituitary_gland1.04019822
56MP0009046_muscle_twitch1.03602804
57MP0003935_abnormal_craniofacial_develop1.03582964
58MP0002752_abnormal_somatic_nervous1.00342643
59MP0002102_abnormal_ear_morphology1.00265354
60MP0005369_muscle_phenotype0.99792236
61MP0000750_abnormal_muscle_regeneration0.98800971
62MP0008058_abnormal_DNA_repair0.98771403
63MP0003755_abnormal_palate_morphology0.97335033
64MP0001879_abnormal_lymphatic_vessel0.96558778
65MP0004085_abnormal_heartbeat0.96095522
66MP0002067_abnormal_sensory_capabilities0.95021118
67MP0002938_white_spotting0.94688247
68MP0001661_extended_life_span0.94206326
69MP0002066_abnormal_motor_capabilities/c0.92965270
70MP0004084_abnormal_cardiac_muscle0.92893326
71MP0000013_abnormal_adipose_tissue0.91568779
72MP0004133_heterotaxia0.90891018
73MP0009697_abnormal_copulation0.90439751
74MP0002152_abnormal_brain_morphology0.88374055
75MP0002095_abnormal_skin_pigmentation0.87674138
76MP0002272_abnormal_nervous_system0.87345790
77MP0002882_abnormal_neuron_morphology0.86172235
78MP0003698_abnormal_male_reproductive0.84960907
79MP0005187_abnormal_penis_morphology0.84411078
80MP0003937_abnormal_limbs/digits/tail_de0.84237277
81MP0005253_abnormal_eye_physiology0.84144544
82MP0003861_abnormal_nervous_system0.82522888
83MP0001970_abnormal_pain_threshold0.79890761
84MP0002822_catalepsy0.76923779
85MP0001348_abnormal_lacrimal_gland0.75926079
86MP0001145_abnormal_male_reproductive0.75726910
87MP0005499_abnormal_olfactory_system0.75215693
88MP0005394_taste/olfaction_phenotype0.75215693
89MP0003948_abnormal_gas_homeostasis0.73632764
90MP0004087_abnormal_muscle_fiber0.73341372
91MP0002837_dystrophic_cardiac_calcinosis0.73143120
92MP0000653_abnormal_sex_gland0.72849596
93MP0003633_abnormal_nervous_system0.72590135
94MP0002210_abnormal_sex_determination0.72328552
95MP0000566_synostosis0.72236810
96MP0009703_decreased_birth_body0.70690796
97MP0002233_abnormal_nose_morphology0.69911958
98MP0003567_abnormal_fetal_cardiomyocyte0.69692918
99MP0010094_abnormal_chromosome_stability0.69672909
100MP0008995_early_reproductive_senescence0.69364393

Predicted human phenotypes

RankGene SetZ-score
1Tetraplegia (HP:0002445)6.17534540
2Pendular nystagmus (HP:0012043)5.55538355
3Abnormality of pyrimidine metabolism (HP:0004353)5.51098726
4Focal motor seizures (HP:0011153)5.45724329
5Hyperglycinemia (HP:0002154)4.18306527
6Focal seizures (HP:0007359)4.03982422
7Action tremor (HP:0002345)3.45787432
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.43441129
9Abnormality of alanine metabolism (HP:0010916)3.43441129
10Hyperalaninemia (HP:0003348)3.43441129
11Birth length less than 3rd percentile (HP:0003561)3.36250125
12Gaze-evoked nystagmus (HP:0000640)3.35901640
13Methylmalonic acidemia (HP:0002912)3.29924268
14Abnormality of the labia minora (HP:0012880)3.18678711
15Lissencephaly (HP:0001339)2.95983229
16Poor speech (HP:0002465)2.90024242
17Meningioma (HP:0002858)2.85548769
18Dysdiadochokinesis (HP:0002075)2.84589173
19Urinary bladder sphincter dysfunction (HP:0002839)2.82780704
20Aplasia/Hypoplasia of the tibia (HP:0005772)2.76080358
21Amyotrophic lateral sclerosis (HP:0007354)2.74101976
22Delayed myelination (HP:0012448)2.67741498
23Short tibia (HP:0005736)2.67554617
24Patellar aplasia (HP:0006443)2.66723016
25Muscular hypotonia of the trunk (HP:0008936)2.64207704
26Impaired vibration sensation in the lower limbs (HP:0002166)2.64149366
27Intention tremor (HP:0002080)2.62500802
28Broad-based gait (HP:0002136)2.62330774
29Tubulointerstitial nephritis (HP:0001970)2.62053644
30Pachygyria (HP:0001302)2.61555444
31Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.52091782
32Degeneration of the lateral corticospinal tracts (HP:0002314)2.52091782
33Aplasia/Hypoplasia of the patella (HP:0006498)2.49072723
34Abnormality of midbrain morphology (HP:0002418)2.40795949
35Molar tooth sign on MRI (HP:0002419)2.40795949
36Abnormality of the corticospinal tract (HP:0002492)2.38791131
37Syncope (HP:0001279)2.35302952
38Abnormality of serine family amino acid metabolism (HP:0010894)2.31681828
39Abnormality of glycine metabolism (HP:0010895)2.31681828
40Nephronophthisis (HP:0000090)2.29303561
41Agnosia (HP:0010524)2.29039492
42Methylmalonic aciduria (HP:0012120)2.28281552
43Horizontal nystagmus (HP:0000666)2.24994450
44Epileptiform EEG discharges (HP:0011182)2.24018500
45Spastic tetraparesis (HP:0001285)2.23074479
46Scanning speech (HP:0002168)2.22248852
47Hypsarrhythmia (HP:0002521)2.19862380
48Abnormal social behavior (HP:0012433)2.19371148
49Impaired social interactions (HP:0000735)2.19371148
50Postnatal microcephaly (HP:0005484)2.17322711
51Drooling (HP:0002307)2.16947375
52Megalencephaly (HP:0001355)2.15402682
53Abnormality of nucleobase metabolism (HP:0010932)2.15198053
54Supernumerary spleens (HP:0009799)2.14388203
55Increased serum pyruvate (HP:0003542)2.13154762
56Delayed CNS myelination (HP:0002188)2.12911872
57Incomplete penetrance (HP:0003829)2.11377132
58Inability to walk (HP:0002540)2.11362562
59Abnormality of serum amino acid levels (HP:0003112)2.09987504
60Long clavicles (HP:0000890)2.08178589
61EEG with generalized epileptiform discharges (HP:0011198)2.07073515
62Subaortic stenosis (HP:0001682)2.05266526
63Abnormality of the left ventricular outflow tract (HP:0011103)2.05266526
64Rimmed vacuoles (HP:0003805)2.03009821
65Prolonged QT interval (HP:0001657)2.02056544
66Pancreatic cysts (HP:0001737)1.99105811
67Poor eye contact (HP:0000817)1.98973616
68Generalized tonic-clonic seizures (HP:0002069)1.98351975
69Polyphagia (HP:0002591)1.96556135
70Abnormality of glycolysis (HP:0004366)1.96009439
71Type I diabetes mellitus (HP:0100651)1.94294076
72Excessive salivation (HP:0003781)1.93570574
73Ulnar claw (HP:0001178)1.92807411
74Severe Myopia (HP:0011003)1.91135543
75Febrile seizures (HP:0002373)1.90879063
76Progressive inability to walk (HP:0002505)1.88638879
77Atrophy/Degeneration involving motor neurons (HP:0007373)1.84191652
78Constricted visual fields (HP:0001133)1.83472372
79Genetic anticipation (HP:0003743)1.82742869
80Attenuation of retinal blood vessels (HP:0007843)1.82281081
81Toxemia of pregnancy (HP:0100603)1.80758311
82Renal hypoplasia (HP:0000089)1.79820311
83Large earlobe (HP:0009748)1.79623999
84Nonprogressive disorder (HP:0003680)1.79290794
85Embryonal renal neoplasm (HP:0011794)1.78688752
86Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.78359187
87Small hand (HP:0200055)1.77697917
88Abnormality of the renal medulla (HP:0100957)1.77163753
89Heterotopia (HP:0002282)1.75403240
90Abnormality of the labia majora (HP:0012881)1.74306150
91Esophageal varix (HP:0002040)1.74192578
92Neonatal respiratory distress (HP:0002643)1.73269763
93Progressive cerebellar ataxia (HP:0002073)1.72791770
94Severe visual impairment (HP:0001141)1.72724483
95Generalized myoclonic seizures (HP:0002123)1.72243926
96Dysmetric saccades (HP:0000641)1.72089806
97Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.71628837
98Tracheomalacia (HP:0002779)1.70250663
99Pancreatic fibrosis (HP:0100732)1.69561771
100Steppage gait (HP:0003376)1.67066908

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.31386631
2YES13.93522485
3FRK3.84172003
4EPHA43.14921426
5TYRO32.56068410
6MAP3K42.56067492
7MAP4K22.53019551
8DYRK22.48703987
9WNK32.28938654
10MAP2K72.27737798
11CLK11.96958451
12PHKG21.92568562
13PHKG11.92568562
14CCNB11.89053290
15MAP3K121.88547291
16CSNK1G21.69894597
17OBSCN1.67282447
18DAPK21.67213955
19MAP2K41.63141530
20BMPR1B1.62482045
21EPHB21.62000647
22EIF2AK31.54114908
23ACVR1B1.48328177
24CSNK1A1L1.41841474
25PLK41.32429030
26SRPK11.31805757
27NTRK21.23026143
28CSNK1G31.22961798
29WEE11.21360008
30ERBB31.21195271
31CASK1.18946797
32GRK51.16800255
33MAPK131.08661007
34CSNK1G11.04412120
35CAMK41.02746564
36CDK51.01646141
37GRK10.98819717
38TIE10.94779392
39EPHA30.94678119
40BCR0.93963901
41CDC70.91072014
42DYRK30.90038572
43CAMKK20.87143417
44UHMK10.86783202
45PLK30.85799940
46SGK20.85288930
47RPS6KA40.81509886
48CDK80.76483938
49NEK10.75800119
50MINK10.74315996
51CAMK2B0.73953769
52ROCK10.73151710
53EIF2AK20.71101799
54PLK20.69820872
55ROCK20.69724771
56STK110.69700507
57GSK3A0.67416624
58MAP2K10.66512351
59SGK4940.66241913
60SGK2230.66241913
61PAK30.64899172
62PRKCE0.61498980
63CAMK2A0.59719828
64MUSK0.58981189
65DYRK1A0.58622828
66CHEK10.56386435
67CSNK1D0.55783888
68FGFR20.55085917
69CAMK10.53373402
70STK160.50360044
71DAPK10.49918922
72CSNK1A10.49397480
73NTRK30.48518892
74CAMK2D0.47198912
75MKNK20.46827212
76CHEK20.43755651
77PRKCZ0.43156571
78ADRBK10.41622588
79ATM0.41560708
80MAP3K30.41062302
81TNIK0.40423443
82PRKACA0.39868960
83ILK0.39716027
84FGR0.39402819
85GSK3B0.39120624
86PAK60.39049080
87ZAK0.38532532
88TAOK10.38431084
89NEK20.35757864
90CDK10.35609179
91MKNK10.34232693
92CAMK2G0.33677092
93PLK10.33625946
94PNCK0.33483977
95RPS6KA30.32738044
96PRKACG0.32517445
97TRIM280.31684571
98PKN10.30918846
99MAPK80.30106647
100KSR10.30018545

Predicted pathways (KEGG)

RankGene SetZ-score
1Pantothenate and CoA biosynthesis_Homo sapiens_hsa007704.34748477
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.47421829
3Nicotine addiction_Homo sapiens_hsa050333.29744888
4beta-Alanine metabolism_Homo sapiens_hsa004103.08001984
5Non-homologous end-joining_Homo sapiens_hsa034502.96985313
6Basal transcription factors_Homo sapiens_hsa030222.51009776
7Base excision repair_Homo sapiens_hsa034102.33346020
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17518362
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09732692
10One carbon pool by folate_Homo sapiens_hsa006702.04408453
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01616245
12Axon guidance_Homo sapiens_hsa043601.94226423
13Morphine addiction_Homo sapiens_hsa050321.74840895
14Dorso-ventral axis formation_Homo sapiens_hsa043201.74594148
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69503128
16GABAergic synapse_Homo sapiens_hsa047271.65509649
17Pyrimidine metabolism_Homo sapiens_hsa002401.63916011
18Propanoate metabolism_Homo sapiens_hsa006401.50679226
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49190153
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.47815091
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47661796
22Nitrogen metabolism_Homo sapiens_hsa009101.47174724
23Fatty acid elongation_Homo sapiens_hsa000621.44735078
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40087721
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.37899433
26RNA transport_Homo sapiens_hsa030131.35359521
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.35085581
28Homologous recombination_Homo sapiens_hsa034401.34231678
29Circadian entrainment_Homo sapiens_hsa047131.33994376
30Cholinergic synapse_Homo sapiens_hsa047251.32988734
31Serotonergic synapse_Homo sapiens_hsa047261.30813560
32Glutamatergic synapse_Homo sapiens_hsa047241.29733233
33Dopaminergic synapse_Homo sapiens_hsa047281.28164901
34Fanconi anemia pathway_Homo sapiens_hsa034601.20212520
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19307507
36RNA polymerase_Homo sapiens_hsa030201.18767231
37Synaptic vesicle cycle_Homo sapiens_hsa047211.18248866
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15271327
39Circadian rhythm_Homo sapiens_hsa047101.09994710
40Taste transduction_Homo sapiens_hsa047421.08637224
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05715273
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05208104
43Cocaine addiction_Homo sapiens_hsa050301.04561333
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04405571
45Linoleic acid metabolism_Homo sapiens_hsa005910.98591744
46Spliceosome_Homo sapiens_hsa030400.97002828
47RNA degradation_Homo sapiens_hsa030180.96395769
48DNA replication_Homo sapiens_hsa030300.95905156
49Insulin secretion_Homo sapiens_hsa049110.91993748
50Butanoate metabolism_Homo sapiens_hsa006500.86951924
51Caffeine metabolism_Homo sapiens_hsa002320.86057858
52Salivary secretion_Homo sapiens_hsa049700.83999873
53mRNA surveillance pathway_Homo sapiens_hsa030150.82626141
54Protein export_Homo sapiens_hsa030600.82469035
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81813893
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80242800
57Ether lipid metabolism_Homo sapiens_hsa005650.79705148
58Collecting duct acid secretion_Homo sapiens_hsa049660.79033626
59Fatty acid biosynthesis_Homo sapiens_hsa000610.74022095
60cAMP signaling pathway_Homo sapiens_hsa040240.72407450
61Mismatch repair_Homo sapiens_hsa034300.72091674
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66600170
63Tryptophan metabolism_Homo sapiens_hsa003800.66466169
64Amphetamine addiction_Homo sapiens_hsa050310.63809486
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63659172
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63628069
67Calcium signaling pathway_Homo sapiens_hsa040200.57267994
68Arginine biosynthesis_Homo sapiens_hsa002200.56920744
69Pyruvate metabolism_Homo sapiens_hsa006200.55285509
70Wnt signaling pathway_Homo sapiens_hsa043100.52519176
71Olfactory transduction_Homo sapiens_hsa047400.51612420
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50833741
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.49545524
74Retinol metabolism_Homo sapiens_hsa008300.49142243
75Long-term potentiation_Homo sapiens_hsa047200.47889455
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46529029
77Purine metabolism_Homo sapiens_hsa002300.46277735
78Fatty acid metabolism_Homo sapiens_hsa012120.44740264
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44685347
80Steroid biosynthesis_Homo sapiens_hsa001000.44581683
81Nucleotide excision repair_Homo sapiens_hsa034200.41247398
82Regulation of autophagy_Homo sapiens_hsa041400.39803010
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37545888
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37406398
85Folate biosynthesis_Homo sapiens_hsa007900.36560200
86Huntingtons disease_Homo sapiens_hsa050160.36141540
87Metabolic pathways_Homo sapiens_hsa011000.35836304
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35723018
89Phototransduction_Homo sapiens_hsa047440.35188164
90Thyroid hormone synthesis_Homo sapiens_hsa049180.34616081
91Gastric acid secretion_Homo sapiens_hsa049710.34570601
92Oocyte meiosis_Homo sapiens_hsa041140.33535686
93Alcoholism_Homo sapiens_hsa050340.31988889
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31434870
95Ras signaling pathway_Homo sapiens_hsa040140.31328489
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29576044
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29471695
98Long-term depression_Homo sapiens_hsa047300.29345388
99Proteasome_Homo sapiens_hsa030500.27314096
100TGF-beta signaling pathway_Homo sapiens_hsa043500.26482366

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