

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of synapse structural plasticity (GO:0051823) | 9.32478662 |
| 2 | pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174) | 6.89425122 |
| 3 | UMP metabolic process (GO:0046049) | 6.89425122 |
| 4 | pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173) | 6.89425122 |
| 5 | UMP biosynthetic process (GO:0006222) | 6.89425122 |
| 6 | acrosome assembly (GO:0001675) | 5.92897571 |
| 7 | presynaptic membrane assembly (GO:0097105) | 5.75934149 |
| 8 | pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130) | 5.74477762 |
| 9 | pyrimidine nucleoside monophosphate metabolic process (GO:0009129) | 5.22191305 |
| 10 | central nervous system projection neuron axonogenesis (GO:0021952) | 5.04443982 |
| 11 | positive regulation of amino acid transport (GO:0051957) | 4.79090696 |
| 12 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 4.60742577 |
| 13 | postsynaptic membrane organization (GO:0001941) | 4.59086202 |
| 14 | presynaptic membrane organization (GO:0097090) | 4.52818313 |
| 15 | regulation of feeding behavior (GO:0060259) | 4.34317147 |
| 16 | tachykinin receptor signaling pathway (GO:0007217) | 4.30173326 |
| 17 | glycosphingolipid biosynthetic process (GO:0006688) | 4.19979946 |
| 18 | atrial cardiac muscle cell action potential (GO:0086014) | 4.10877780 |
| 19 | central nervous system neuron axonogenesis (GO:0021955) | 4.00776733 |
| 20 | positive regulation of meiosis (GO:0045836) | 3.99160115 |
| 21 | regulation of glucokinase activity (GO:0033131) | 3.98480650 |
| 22 | regulation of hexokinase activity (GO:1903299) | 3.98480650 |
| 23 | regulation of DNA endoreduplication (GO:0032875) | 3.94519819 |
| 24 | pyrimidine nucleobase metabolic process (GO:0006206) | 3.93272239 |
| 25 | ganglion development (GO:0061548) | 3.89529118 |
| 26 | brain morphogenesis (GO:0048854) | 3.87778975 |
| 27 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.86388155 |
| 28 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.84075148 |
| 29 | protein polyglutamylation (GO:0018095) | 3.79748050 |
| 30 | sympathetic nervous system development (GO:0048485) | 3.78186354 |
| 31 | pyrimidine-containing compound catabolic process (GO:0072529) | 3.67906643 |
| 32 | positive regulation of meiotic cell cycle (GO:0051446) | 3.67339071 |
| 33 | positive regulation of oligodendrocyte differentiation (GO:0048714) | 3.66792000 |
| 34 | vocalization behavior (GO:0071625) | 3.65977969 |
| 35 | sialylation (GO:0097503) | 3.61085776 |
| 36 | facial nerve structural organization (GO:0021612) | 3.59778307 |
| 37 | microtubule nucleation (GO:0007020) | 3.56428256 |
| 38 | regulation of synapse organization (GO:0050807) | 3.53341104 |
| 39 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.50140053 |
| 40 | pyrimidine ribonucleoside biosynthetic process (GO:0046132) | 3.43617455 |
| 41 | retinal ganglion cell axon guidance (GO:0031290) | 3.40401016 |
| 42 | layer formation in cerebral cortex (GO:0021819) | 3.34344567 |
| 43 | olfactory bulb development (GO:0021772) | 3.31668060 |
| 44 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 3.30050351 |
| 45 | neuron cell-cell adhesion (GO:0007158) | 3.29704113 |
| 46 | regulation of male gonad development (GO:2000018) | 3.29457419 |
| 47 | pyrimidine ribonucleotide biosynthetic process (GO:0009220) | 3.28783720 |
| 48 | regulation of cardiac muscle cell contraction (GO:0086004) | 3.27781606 |
| 49 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.22567544 |
| 50 | response to methylmercury (GO:0051597) | 3.21891693 |
| 51 | axon extension (GO:0048675) | 3.21252881 |
| 52 | grooming behavior (GO:0007625) | 3.20521207 |
| 53 | centrosome duplication (GO:0051298) | 3.18521638 |
| 54 | positive regulation of gastrulation (GO:2000543) | 3.17973674 |
| 55 | cranial nerve structural organization (GO:0021604) | 3.15099940 |
| 56 | regulation of dendritic spine development (GO:0060998) | 3.14946496 |
| 57 | positive regulation of myoblast differentiation (GO:0045663) | 3.10548228 |
| 58 | cerebral cortex neuron differentiation (GO:0021895) | 3.10210140 |
| 59 | pyrimidine ribonucleotide metabolic process (GO:0009218) | 3.10001133 |
| 60 | regulation of synapse assembly (GO:0051963) | 3.05725051 |
| 61 | membrane invagination (GO:0010324) | 3.04770753 |
| 62 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.04076772 |
| 63 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.04076772 |
| 64 | NADH dehydrogenase complex assembly (GO:0010257) | 3.04076772 |
| 65 | positive regulation of embryonic development (GO:0040019) | 3.01745207 |
| 66 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 3.00899157 |
| 67 | cranial nerve morphogenesis (GO:0021602) | 3.00782434 |
| 68 | proline transport (GO:0015824) | 2.98183774 |
| 69 | homocysteine metabolic process (GO:0050667) | 2.97655513 |
| 70 | regulation of cilium movement (GO:0003352) | 2.96143677 |
| 71 | pyrimidine nucleoside catabolic process (GO:0046135) | 2.90310545 |
| 72 | membrane disassembly (GO:0030397) | 2.89498060 |
| 73 | nuclear envelope disassembly (GO:0051081) | 2.89498060 |
| 74 | regulation of glutamate secretion (GO:0014048) | 2.88438928 |
| 75 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 2.85219194 |
| 76 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 2.83322798 |
| 77 | regulation of actin filament-based movement (GO:1903115) | 2.82306064 |
| 78 | fatty acid elongation (GO:0030497) | 2.81704121 |
| 79 | pyrimidine nucleotide biosynthetic process (GO:0006221) | 2.81223776 |
| 80 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 2.78340533 |
| 81 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 2.77364879 |
| 82 | response to inactivity (GO:0014854) | 2.73387962 |
| 83 | nonmotile primary cilium assembly (GO:0035058) | 2.71005039 |
| 84 | phagocytosis, engulfment (GO:0006911) | 2.69964892 |
| 85 | regulation of gonadotropin secretion (GO:0032276) | 2.68839874 |
| 86 | barbed-end actin filament capping (GO:0051016) | 2.67757744 |
| 87 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 2.67218696 |
| 88 | negative chemotaxis (GO:0050919) | 2.64744221 |
| 89 | clathrin coat assembly (GO:0048268) | 2.63477277 |
| 90 | protein-cofactor linkage (GO:0018065) | 2.62019946 |
| 91 | positive regulation of amine transport (GO:0051954) | 2.61870469 |
| 92 | mitotic nuclear envelope disassembly (GO:0007077) | 2.60021050 |
| 93 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.58986224 |
| 94 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.58986224 |
| 95 | positive regulation of potassium ion transport (GO:0043268) | 2.57993998 |
| 96 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 2.57705171 |
| 97 | spinal cord development (GO:0021510) | 2.57039367 |
| 98 | neuron projection extension (GO:1990138) | 2.54016185 |
| 99 | pyrimidine nucleobase catabolic process (GO:0006208) | 14.9589810 |
| 100 | nucleobase catabolic process (GO:0046113) | 11.9581890 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.48948862 |
| 2 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 4.04033907 |
| 3 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.39242291 |
| 4 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.32764878 |
| 5 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 3.31368199 |
| 6 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 3.05060480 |
| 7 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.91484762 |
| 8 | EWS_26573619_Chip-Seq_HEK293_Human | 2.70196769 |
| 9 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.65572109 |
| 10 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 2.53553710 |
| 11 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.50548865 |
| 12 | FUS_26573619_Chip-Seq_HEK293_Human | 2.49986757 |
| 13 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.47262204 |
| 14 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.41868608 |
| 15 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.39704157 |
| 16 | P300_19829295_ChIP-Seq_ESCs_Human | 2.35826035 |
| 17 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.29533790 |
| 18 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.21768858 |
| 19 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.21428733 |
| 20 | VDR_22108803_ChIP-Seq_LS180_Human | 2.16709544 |
| 21 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.09975594 |
| 22 | RNF2_27304074_Chip-Seq_NSC_Mouse | 2.03877968 |
| 23 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.03341177 |
| 24 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.01228943 |
| 25 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.93972122 |
| 26 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.93776794 |
| 27 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.93507226 |
| 28 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.87058165 |
| 29 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.86793413 |
| 30 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.83750150 |
| 31 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.81658584 |
| 32 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.78553279 |
| 33 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.76417688 |
| 34 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.73770966 |
| 35 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.72917746 |
| 36 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.71497655 |
| 37 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.70930605 |
| 38 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.65077178 |
| 39 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.63239629 |
| 40 | KDM2B_26808549_Chip-Seq_REH_Human | 1.62096999 |
| 41 | STAT3_23295773_ChIP-Seq_U87_Human | 1.55773098 |
| 42 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.52901262 |
| 43 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.52881734 |
| 44 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.52867746 |
| 45 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.48818217 |
| 46 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.47846006 |
| 47 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.46000705 |
| 48 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.44976509 |
| 49 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.44472904 |
| 50 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.42218008 |
| 51 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.41896035 |
| 52 | TCF4_23295773_ChIP-Seq_U87_Human | 1.41678108 |
| 53 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.40457891 |
| 54 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.35808840 |
| 55 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.35464929 |
| 56 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.33740179 |
| 57 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.30360350 |
| 58 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.29416880 |
| 59 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.26513708 |
| 60 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.26087648 |
| 61 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.24950650 |
| 62 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.23946780 |
| 63 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.23520542 |
| 64 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.23229136 |
| 65 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.22490365 |
| 66 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.18647367 |
| 67 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.15899318 |
| 68 | AR_25329375_ChIP-Seq_VCAP_Human | 1.15438647 |
| 69 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.15072053 |
| 70 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.14930431 |
| 71 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.13119219 |
| 72 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.12656730 |
| 73 | JUN_21703547_ChIP-Seq_K562_Human | 1.12648040 |
| 74 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.11395563 |
| 75 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.11326125 |
| 76 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.10146594 |
| 77 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.10080764 |
| 78 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.09825444 |
| 79 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.06960163 |
| 80 | POU5F1_18347094_ChIP-ChIP_MESCs_Mouse | 1.06889128 |
| 81 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.06721878 |
| 82 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.05595041 |
| 83 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.02924952 |
| 84 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.01834466 |
| 85 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.01506240 |
| 86 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.00022553 |
| 87 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 0.98667413 |
| 88 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.98513800 |
| 89 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 0.98027075 |
| 90 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.97327584 |
| 91 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.97292500 |
| 92 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.97152175 |
| 93 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.97152175 |
| 94 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 0.96694214 |
| 95 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.96406722 |
| 96 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 0.96359552 |
| 97 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 0.96127572 |
| 98 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 0.96127572 |
| 99 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.93823204 |
| 100 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 0.93332213 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000516_abnormal_urinary_system | 4.19045465 |
| 2 | MP0005367_renal/urinary_system_phenotyp | 4.19045465 |
| 3 | MP0004859_abnormal_synaptic_plasticity | 3.25986239 |
| 4 | MP0006054_spinal_hemorrhage | 2.97389920 |
| 5 | MP0001486_abnormal_startle_reflex | 2.80609982 |
| 6 | MP0000749_muscle_degeneration | 2.80104326 |
| 7 | MP0001529_abnormal_vocalization | 2.78806650 |
| 8 | MP0003880_abnormal_central_pattern | 2.74829459 |
| 9 | MP0008872_abnormal_physiological_respon | 2.60214182 |
| 10 | MP0003656_abnormal_erythrocyte_physiolo | 2.24586540 |
| 11 | MP0000778_abnormal_nervous_system | 2.24091990 |
| 12 | MP0001177_atelectasis | 2.10109448 |
| 13 | MP0002736_abnormal_nociception_after | 2.08587997 |
| 14 | MP0002751_abnormal_autonomic_nervous | 2.02157277 |
| 15 | MP0001984_abnormal_olfaction | 1.91726408 |
| 16 | MP0000747_muscle_weakness | 1.90059567 |
| 17 | MP0004147_increased_porphyrin_level | 1.84961946 |
| 18 | MP0002234_abnormal_pharynx_morphology | 1.84321177 |
| 19 | MP0002184_abnormal_innervation | 1.83223515 |
| 20 | MP0005076_abnormal_cell_differentiation | 1.73188546 |
| 21 | MP0004145_abnormal_muscle_electrophysio | 1.70221513 |
| 22 | MP0003635_abnormal_synaptic_transmissio | 1.68385770 |
| 23 | MP0000049_abnormal_middle_ear | 1.64628161 |
| 24 | MP0005670_abnormal_white_adipose | 1.64319826 |
| 25 | MP0009745_abnormal_behavioral_response | 1.58285459 |
| 26 | MP0002063_abnormal_learning/memory/cond | 1.55837765 |
| 27 | MP0003137_abnormal_impulse_conducting | 1.55807005 |
| 28 | MP0002269_muscular_atrophy | 1.53559738 |
| 29 | MP0000751_myopathy | 1.50038130 |
| 30 | MP0000955_abnormal_spinal_cord | 1.47306545 |
| 31 | MP0002064_seizures | 1.43429488 |
| 32 | MP0002735_abnormal_chemical_nociception | 1.43273840 |
| 33 | MP0008057_abnormal_DNA_replication | 1.37649189 |
| 34 | MP0000733_abnormal_muscle_development | 1.34359345 |
| 35 | MP0004924_abnormal_behavior | 1.29854554 |
| 36 | MP0005386_behavior/neurological_phenoty | 1.29854554 |
| 37 | MP0002106_abnormal_muscle_physiology | 1.29206589 |
| 38 | MP0002734_abnormal_mechanical_nocicepti | 1.29097275 |
| 39 | MP0004043_abnormal_pH_regulation | 1.28267457 |
| 40 | MP0004270_analgesia | 1.28242566 |
| 41 | MP0001968_abnormal_touch/_nociception | 1.26264737 |
| 42 | MP0004811_abnormal_neuron_physiology | 1.24852045 |
| 43 | MP0006276_abnormal_autonomic_nervous | 1.24143243 |
| 44 | MP0010368_abnormal_lymphatic_system | 1.23260039 |
| 45 | MP0000534_abnormal_ureter_morphology | 1.21887099 |
| 46 | MP0008789_abnormal_olfactory_epithelium | 1.21870113 |
| 47 | MP0000759_abnormal_skeletal_muscle | 1.20644735 |
| 48 | MP0000647_abnormal_sebaceous_gland | 1.17688572 |
| 49 | MP0003136_yellow_coat_color | 1.14396636 |
| 50 | MP0004142_abnormal_muscle_tone | 1.13705836 |
| 51 | MP0005551_abnormal_eye_electrophysiolog | 1.11102870 |
| 52 | MP0004885_abnormal_endolymph | 1.08869630 |
| 53 | MP0002572_abnormal_emotion/affect_behav | 1.05440175 |
| 54 | MP0004215_abnormal_myocardial_fiber | 1.04860429 |
| 55 | MP0005646_abnormal_pituitary_gland | 1.04019822 |
| 56 | MP0009046_muscle_twitch | 1.03602804 |
| 57 | MP0003935_abnormal_craniofacial_develop | 1.03582964 |
| 58 | MP0002752_abnormal_somatic_nervous | 1.00342643 |
| 59 | MP0002102_abnormal_ear_morphology | 1.00265354 |
| 60 | MP0005369_muscle_phenotype | 0.99792236 |
| 61 | MP0000750_abnormal_muscle_regeneration | 0.98800971 |
| 62 | MP0008058_abnormal_DNA_repair | 0.98771403 |
| 63 | MP0003755_abnormal_palate_morphology | 0.97335033 |
| 64 | MP0001879_abnormal_lymphatic_vessel | 0.96558778 |
| 65 | MP0004085_abnormal_heartbeat | 0.96095522 |
| 66 | MP0002067_abnormal_sensory_capabilities | 0.95021118 |
| 67 | MP0002938_white_spotting | 0.94688247 |
| 68 | MP0001661_extended_life_span | 0.94206326 |
| 69 | MP0002066_abnormal_motor_capabilities/c | 0.92965270 |
| 70 | MP0004084_abnormal_cardiac_muscle | 0.92893326 |
| 71 | MP0000013_abnormal_adipose_tissue | 0.91568779 |
| 72 | MP0004133_heterotaxia | 0.90891018 |
| 73 | MP0009697_abnormal_copulation | 0.90439751 |
| 74 | MP0002152_abnormal_brain_morphology | 0.88374055 |
| 75 | MP0002095_abnormal_skin_pigmentation | 0.87674138 |
| 76 | MP0002272_abnormal_nervous_system | 0.87345790 |
| 77 | MP0002882_abnormal_neuron_morphology | 0.86172235 |
| 78 | MP0003698_abnormal_male_reproductive | 0.84960907 |
| 79 | MP0005187_abnormal_penis_morphology | 0.84411078 |
| 80 | MP0003937_abnormal_limbs/digits/tail_de | 0.84237277 |
| 81 | MP0005253_abnormal_eye_physiology | 0.84144544 |
| 82 | MP0003861_abnormal_nervous_system | 0.82522888 |
| 83 | MP0001970_abnormal_pain_threshold | 0.79890761 |
| 84 | MP0002822_catalepsy | 0.76923779 |
| 85 | MP0001348_abnormal_lacrimal_gland | 0.75926079 |
| 86 | MP0001145_abnormal_male_reproductive | 0.75726910 |
| 87 | MP0005499_abnormal_olfactory_system | 0.75215693 |
| 88 | MP0005394_taste/olfaction_phenotype | 0.75215693 |
| 89 | MP0003948_abnormal_gas_homeostasis | 0.73632764 |
| 90 | MP0004087_abnormal_muscle_fiber | 0.73341372 |
| 91 | MP0002837_dystrophic_cardiac_calcinosis | 0.73143120 |
| 92 | MP0000653_abnormal_sex_gland | 0.72849596 |
| 93 | MP0003633_abnormal_nervous_system | 0.72590135 |
| 94 | MP0002210_abnormal_sex_determination | 0.72328552 |
| 95 | MP0000566_synostosis | 0.72236810 |
| 96 | MP0009703_decreased_birth_body | 0.70690796 |
| 97 | MP0002233_abnormal_nose_morphology | 0.69911958 |
| 98 | MP0003567_abnormal_fetal_cardiomyocyte | 0.69692918 |
| 99 | MP0010094_abnormal_chromosome_stability | 0.69672909 |
| 100 | MP0008995_early_reproductive_senescence | 0.69364393 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Tetraplegia (HP:0002445) | 6.17534540 |
| 2 | Pendular nystagmus (HP:0012043) | 5.55538355 |
| 3 | Abnormality of pyrimidine metabolism (HP:0004353) | 5.51098726 |
| 4 | Focal motor seizures (HP:0011153) | 5.45724329 |
| 5 | Hyperglycinemia (HP:0002154) | 4.18306527 |
| 6 | Focal seizures (HP:0007359) | 4.03982422 |
| 7 | Action tremor (HP:0002345) | 3.45787432 |
| 8 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.43441129 |
| 9 | Abnormality of alanine metabolism (HP:0010916) | 3.43441129 |
| 10 | Hyperalaninemia (HP:0003348) | 3.43441129 |
| 11 | Birth length less than 3rd percentile (HP:0003561) | 3.36250125 |
| 12 | Gaze-evoked nystagmus (HP:0000640) | 3.35901640 |
| 13 | Methylmalonic acidemia (HP:0002912) | 3.29924268 |
| 14 | Abnormality of the labia minora (HP:0012880) | 3.18678711 |
| 15 | Lissencephaly (HP:0001339) | 2.95983229 |
| 16 | Poor speech (HP:0002465) | 2.90024242 |
| 17 | Meningioma (HP:0002858) | 2.85548769 |
| 18 | Dysdiadochokinesis (HP:0002075) | 2.84589173 |
| 19 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.82780704 |
| 20 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.76080358 |
| 21 | Amyotrophic lateral sclerosis (HP:0007354) | 2.74101976 |
| 22 | Delayed myelination (HP:0012448) | 2.67741498 |
| 23 | Short tibia (HP:0005736) | 2.67554617 |
| 24 | Patellar aplasia (HP:0006443) | 2.66723016 |
| 25 | Muscular hypotonia of the trunk (HP:0008936) | 2.64207704 |
| 26 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.64149366 |
| 27 | Intention tremor (HP:0002080) | 2.62500802 |
| 28 | Broad-based gait (HP:0002136) | 2.62330774 |
| 29 | Tubulointerstitial nephritis (HP:0001970) | 2.62053644 |
| 30 | Pachygyria (HP:0001302) | 2.61555444 |
| 31 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.52091782 |
| 32 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.52091782 |
| 33 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.49072723 |
| 34 | Abnormality of midbrain morphology (HP:0002418) | 2.40795949 |
| 35 | Molar tooth sign on MRI (HP:0002419) | 2.40795949 |
| 36 | Abnormality of the corticospinal tract (HP:0002492) | 2.38791131 |
| 37 | Syncope (HP:0001279) | 2.35302952 |
| 38 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.31681828 |
| 39 | Abnormality of glycine metabolism (HP:0010895) | 2.31681828 |
| 40 | Nephronophthisis (HP:0000090) | 2.29303561 |
| 41 | Agnosia (HP:0010524) | 2.29039492 |
| 42 | Methylmalonic aciduria (HP:0012120) | 2.28281552 |
| 43 | Horizontal nystagmus (HP:0000666) | 2.24994450 |
| 44 | Epileptiform EEG discharges (HP:0011182) | 2.24018500 |
| 45 | Spastic tetraparesis (HP:0001285) | 2.23074479 |
| 46 | Scanning speech (HP:0002168) | 2.22248852 |
| 47 | Hypsarrhythmia (HP:0002521) | 2.19862380 |
| 48 | Abnormal social behavior (HP:0012433) | 2.19371148 |
| 49 | Impaired social interactions (HP:0000735) | 2.19371148 |
| 50 | Postnatal microcephaly (HP:0005484) | 2.17322711 |
| 51 | Drooling (HP:0002307) | 2.16947375 |
| 52 | Megalencephaly (HP:0001355) | 2.15402682 |
| 53 | Abnormality of nucleobase metabolism (HP:0010932) | 2.15198053 |
| 54 | Supernumerary spleens (HP:0009799) | 2.14388203 |
| 55 | Increased serum pyruvate (HP:0003542) | 2.13154762 |
| 56 | Delayed CNS myelination (HP:0002188) | 2.12911872 |
| 57 | Incomplete penetrance (HP:0003829) | 2.11377132 |
| 58 | Inability to walk (HP:0002540) | 2.11362562 |
| 59 | Abnormality of serum amino acid levels (HP:0003112) | 2.09987504 |
| 60 | Long clavicles (HP:0000890) | 2.08178589 |
| 61 | EEG with generalized epileptiform discharges (HP:0011198) | 2.07073515 |
| 62 | Subaortic stenosis (HP:0001682) | 2.05266526 |
| 63 | Abnormality of the left ventricular outflow tract (HP:0011103) | 2.05266526 |
| 64 | Rimmed vacuoles (HP:0003805) | 2.03009821 |
| 65 | Prolonged QT interval (HP:0001657) | 2.02056544 |
| 66 | Pancreatic cysts (HP:0001737) | 1.99105811 |
| 67 | Poor eye contact (HP:0000817) | 1.98973616 |
| 68 | Generalized tonic-clonic seizures (HP:0002069) | 1.98351975 |
| 69 | Polyphagia (HP:0002591) | 1.96556135 |
| 70 | Abnormality of glycolysis (HP:0004366) | 1.96009439 |
| 71 | Type I diabetes mellitus (HP:0100651) | 1.94294076 |
| 72 | Excessive salivation (HP:0003781) | 1.93570574 |
| 73 | Ulnar claw (HP:0001178) | 1.92807411 |
| 74 | Severe Myopia (HP:0011003) | 1.91135543 |
| 75 | Febrile seizures (HP:0002373) | 1.90879063 |
| 76 | Progressive inability to walk (HP:0002505) | 1.88638879 |
| 77 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.84191652 |
| 78 | Constricted visual fields (HP:0001133) | 1.83472372 |
| 79 | Genetic anticipation (HP:0003743) | 1.82742869 |
| 80 | Attenuation of retinal blood vessels (HP:0007843) | 1.82281081 |
| 81 | Toxemia of pregnancy (HP:0100603) | 1.80758311 |
| 82 | Renal hypoplasia (HP:0000089) | 1.79820311 |
| 83 | Large earlobe (HP:0009748) | 1.79623999 |
| 84 | Nonprogressive disorder (HP:0003680) | 1.79290794 |
| 85 | Embryonal renal neoplasm (HP:0011794) | 1.78688752 |
| 86 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.78359187 |
| 87 | Small hand (HP:0200055) | 1.77697917 |
| 88 | Abnormality of the renal medulla (HP:0100957) | 1.77163753 |
| 89 | Heterotopia (HP:0002282) | 1.75403240 |
| 90 | Abnormality of the labia majora (HP:0012881) | 1.74306150 |
| 91 | Esophageal varix (HP:0002040) | 1.74192578 |
| 92 | Neonatal respiratory distress (HP:0002643) | 1.73269763 |
| 93 | Progressive cerebellar ataxia (HP:0002073) | 1.72791770 |
| 94 | Severe visual impairment (HP:0001141) | 1.72724483 |
| 95 | Generalized myoclonic seizures (HP:0002123) | 1.72243926 |
| 96 | Dysmetric saccades (HP:0000641) | 1.72089806 |
| 97 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 1.71628837 |
| 98 | Tracheomalacia (HP:0002779) | 1.70250663 |
| 99 | Pancreatic fibrosis (HP:0100732) | 1.69561771 |
| 100 | Steppage gait (HP:0003376) | 1.67066908 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 6.31386631 |
| 2 | YES1 | 3.93522485 |
| 3 | FRK | 3.84172003 |
| 4 | EPHA4 | 3.14921426 |
| 5 | TYRO3 | 2.56068410 |
| 6 | MAP3K4 | 2.56067492 |
| 7 | MAP4K2 | 2.53019551 |
| 8 | DYRK2 | 2.48703987 |
| 9 | WNK3 | 2.28938654 |
| 10 | MAP2K7 | 2.27737798 |
| 11 | CLK1 | 1.96958451 |
| 12 | PHKG2 | 1.92568562 |
| 13 | PHKG1 | 1.92568562 |
| 14 | CCNB1 | 1.89053290 |
| 15 | MAP3K12 | 1.88547291 |
| 16 | CSNK1G2 | 1.69894597 |
| 17 | OBSCN | 1.67282447 |
| 18 | DAPK2 | 1.67213955 |
| 19 | MAP2K4 | 1.63141530 |
| 20 | BMPR1B | 1.62482045 |
| 21 | EPHB2 | 1.62000647 |
| 22 | EIF2AK3 | 1.54114908 |
| 23 | ACVR1B | 1.48328177 |
| 24 | CSNK1A1L | 1.41841474 |
| 25 | PLK4 | 1.32429030 |
| 26 | SRPK1 | 1.31805757 |
| 27 | NTRK2 | 1.23026143 |
| 28 | CSNK1G3 | 1.22961798 |
| 29 | WEE1 | 1.21360008 |
| 30 | ERBB3 | 1.21195271 |
| 31 | CASK | 1.18946797 |
| 32 | GRK5 | 1.16800255 |
| 33 | MAPK13 | 1.08661007 |
| 34 | CSNK1G1 | 1.04412120 |
| 35 | CAMK4 | 1.02746564 |
| 36 | CDK5 | 1.01646141 |
| 37 | GRK1 | 0.98819717 |
| 38 | TIE1 | 0.94779392 |
| 39 | EPHA3 | 0.94678119 |
| 40 | BCR | 0.93963901 |
| 41 | CDC7 | 0.91072014 |
| 42 | DYRK3 | 0.90038572 |
| 43 | CAMKK2 | 0.87143417 |
| 44 | UHMK1 | 0.86783202 |
| 45 | PLK3 | 0.85799940 |
| 46 | SGK2 | 0.85288930 |
| 47 | RPS6KA4 | 0.81509886 |
| 48 | CDK8 | 0.76483938 |
| 49 | NEK1 | 0.75800119 |
| 50 | MINK1 | 0.74315996 |
| 51 | CAMK2B | 0.73953769 |
| 52 | ROCK1 | 0.73151710 |
| 53 | EIF2AK2 | 0.71101799 |
| 54 | PLK2 | 0.69820872 |
| 55 | ROCK2 | 0.69724771 |
| 56 | STK11 | 0.69700507 |
| 57 | GSK3A | 0.67416624 |
| 58 | MAP2K1 | 0.66512351 |
| 59 | SGK494 | 0.66241913 |
| 60 | SGK223 | 0.66241913 |
| 61 | PAK3 | 0.64899172 |
| 62 | PRKCE | 0.61498980 |
| 63 | CAMK2A | 0.59719828 |
| 64 | MUSK | 0.58981189 |
| 65 | DYRK1A | 0.58622828 |
| 66 | CHEK1 | 0.56386435 |
| 67 | CSNK1D | 0.55783888 |
| 68 | FGFR2 | 0.55085917 |
| 69 | CAMK1 | 0.53373402 |
| 70 | STK16 | 0.50360044 |
| 71 | DAPK1 | 0.49918922 |
| 72 | CSNK1A1 | 0.49397480 |
| 73 | NTRK3 | 0.48518892 |
| 74 | CAMK2D | 0.47198912 |
| 75 | MKNK2 | 0.46827212 |
| 76 | CHEK2 | 0.43755651 |
| 77 | PRKCZ | 0.43156571 |
| 78 | ADRBK1 | 0.41622588 |
| 79 | ATM | 0.41560708 |
| 80 | MAP3K3 | 0.41062302 |
| 81 | TNIK | 0.40423443 |
| 82 | PRKACA | 0.39868960 |
| 83 | ILK | 0.39716027 |
| 84 | FGR | 0.39402819 |
| 85 | GSK3B | 0.39120624 |
| 86 | PAK6 | 0.39049080 |
| 87 | ZAK | 0.38532532 |
| 88 | TAOK1 | 0.38431084 |
| 89 | NEK2 | 0.35757864 |
| 90 | CDK1 | 0.35609179 |
| 91 | MKNK1 | 0.34232693 |
| 92 | CAMK2G | 0.33677092 |
| 93 | PLK1 | 0.33625946 |
| 94 | PNCK | 0.33483977 |
| 95 | RPS6KA3 | 0.32738044 |
| 96 | PRKACG | 0.32517445 |
| 97 | TRIM28 | 0.31684571 |
| 98 | PKN1 | 0.30918846 |
| 99 | MAPK8 | 0.30106647 |
| 100 | KSR1 | 0.30018545 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 4.34748477 |
| 2 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 3.47421829 |
| 3 | Nicotine addiction_Homo sapiens_hsa05033 | 3.29744888 |
| 4 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 3.08001984 |
| 5 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.96985313 |
| 6 | Basal transcription factors_Homo sapiens_hsa03022 | 2.51009776 |
| 7 | Base excision repair_Homo sapiens_hsa03410 | 2.33346020 |
| 8 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 2.17518362 |
| 9 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.09732692 |
| 10 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.04408453 |
| 11 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 2.01616245 |
| 12 | Axon guidance_Homo sapiens_hsa04360 | 1.94226423 |
| 13 | Morphine addiction_Homo sapiens_hsa05032 | 1.74840895 |
| 14 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.74594148 |
| 15 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.69503128 |
| 16 | GABAergic synapse_Homo sapiens_hsa04727 | 1.65509649 |
| 17 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.63916011 |
| 18 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.50679226 |
| 19 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.49190153 |
| 20 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.47815091 |
| 21 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.47661796 |
| 22 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.47174724 |
| 23 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.44735078 |
| 24 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.40087721 |
| 25 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.37899433 |
| 26 | RNA transport_Homo sapiens_hsa03013 | 1.35359521 |
| 27 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.35085581 |
| 28 | Homologous recombination_Homo sapiens_hsa03440 | 1.34231678 |
| 29 | Circadian entrainment_Homo sapiens_hsa04713 | 1.33994376 |
| 30 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.32988734 |
| 31 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.30813560 |
| 32 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.29733233 |
| 33 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.28164901 |
| 34 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.20212520 |
| 35 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.19307507 |
| 36 | RNA polymerase_Homo sapiens_hsa03020 | 1.18767231 |
| 37 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.18248866 |
| 38 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.15271327 |
| 39 | Circadian rhythm_Homo sapiens_hsa04710 | 1.09994710 |
| 40 | Taste transduction_Homo sapiens_hsa04742 | 1.08637224 |
| 41 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.05715273 |
| 42 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.05208104 |
| 43 | Cocaine addiction_Homo sapiens_hsa05030 | 1.04561333 |
| 44 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.04405571 |
| 45 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.98591744 |
| 46 | Spliceosome_Homo sapiens_hsa03040 | 0.97002828 |
| 47 | RNA degradation_Homo sapiens_hsa03018 | 0.96395769 |
| 48 | DNA replication_Homo sapiens_hsa03030 | 0.95905156 |
| 49 | Insulin secretion_Homo sapiens_hsa04911 | 0.91993748 |
| 50 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.86951924 |
| 51 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.86057858 |
| 52 | Salivary secretion_Homo sapiens_hsa04970 | 0.83999873 |
| 53 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.82626141 |
| 54 | Protein export_Homo sapiens_hsa03060 | 0.82469035 |
| 55 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.81813893 |
| 56 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.80242800 |
| 57 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.79705148 |
| 58 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.79033626 |
| 59 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.74022095 |
| 60 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.72407450 |
| 61 | Mismatch repair_Homo sapiens_hsa03430 | 0.72091674 |
| 62 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.66600170 |
| 63 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.66466169 |
| 64 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.63809486 |
| 65 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.63659172 |
| 66 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.63628069 |
| 67 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.57267994 |
| 68 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.56920744 |
| 69 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.55285509 |
| 70 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.52519176 |
| 71 | Olfactory transduction_Homo sapiens_hsa04740 | 0.51612420 |
| 72 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.50833741 |
| 73 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.49545524 |
| 74 | Retinol metabolism_Homo sapiens_hsa00830 | 0.49142243 |
| 75 | Long-term potentiation_Homo sapiens_hsa04720 | 0.47889455 |
| 76 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.46529029 |
| 77 | Purine metabolism_Homo sapiens_hsa00230 | 0.46277735 |
| 78 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.44740264 |
| 79 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.44685347 |
| 80 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.44581683 |
| 81 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.41247398 |
| 82 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.39803010 |
| 83 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.37545888 |
| 84 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.37406398 |
| 85 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.36560200 |
| 86 | Huntingtons disease_Homo sapiens_hsa05016 | 0.36141540 |
| 87 | Metabolic pathways_Homo sapiens_hsa01100 | 0.35836304 |
| 88 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.35723018 |
| 89 | Phototransduction_Homo sapiens_hsa04744 | 0.35188164 |
| 90 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.34616081 |
| 91 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.34570601 |
| 92 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.33535686 |
| 93 | Alcoholism_Homo sapiens_hsa05034 | 0.31988889 |
| 94 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.31434870 |
| 95 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.31328489 |
| 96 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.29576044 |
| 97 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.29471695 |
| 98 | Long-term depression_Homo sapiens_hsa04730 | 0.29345388 |
| 99 | Proteasome_Homo sapiens_hsa03050 | 0.27314096 |
| 100 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.26482366 |

