RANP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)6.64325630
2proteasome assembly (GO:0043248)6.01676487
3regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.48558577
4regulation of immunoglobulin secretion (GO:0051023)5.42004199
5positive regulation of interleukin-17 production (GO:0032740)4.81260385
6regulation of isotype switching to IgG isotypes (GO:0048302)4.57258436
7negative regulation of dendrite development (GO:2000171)4.51382027
8negative regulation of B cell apoptotic process (GO:0002903)4.48224534
9transcription from mitochondrial promoter (GO:0006390)4.48184773
10regulation of collateral sprouting (GO:0048670)4.47718942
11regulation of regulatory T cell differentiation (GO:0045589)4.47455853
12DNA deamination (GO:0045006)4.45106022
13DNA double-strand break processing (GO:0000729)4.13540155
14somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)4.05907308
15somatic diversification of immunoglobulins involved in immune response (GO:0002208)4.05907308
16isotype switching (GO:0045190)4.05907308
17maturation of 5.8S rRNA (GO:0000460)3.99549080
18proline transport (GO:0015824)3.95118286
19DNA damage response, detection of DNA damage (GO:0042769)3.86908248
20inositol phosphate catabolic process (GO:0071545)3.83220502
21positive regulation of isotype switching (GO:0045830)3.76157464
22negative regulation of protein oligomerization (GO:0032460)3.68539337
23somatic hypermutation of immunoglobulin genes (GO:0016446)3.65602202
24somatic diversification of immune receptors via somatic mutation (GO:0002566)3.65602202
25GTP biosynthetic process (GO:0006183)3.60477982
26inositol phosphate dephosphorylation (GO:0046855)3.59572351
27phosphorylated carbohydrate dephosphorylation (GO:0046838)3.59572351
28chemosensory behavior (GO:0007635)3.54568763
29rRNA catabolic process (GO:0016075)3.53403827
30peptidyl-histidine modification (GO:0018202)3.52537107
31negative regulation of lymphocyte apoptotic process (GO:0070229)3.51816951
32regulation of B cell apoptotic process (GO:0002902)3.49524093
33positive regulation of protein homodimerization activity (GO:0090073)3.42209425
34UTP metabolic process (GO:0046051)3.39421960
35polyol catabolic process (GO:0046174)3.37193270
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.36086757
37rRNA modification (GO:0000154)3.35474299
38somatic diversification of immunoglobulins (GO:0016445)3.33656244
39DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.30929461
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.29846246
41necroptotic process (GO:0070266)3.28090544
42positive regulation of DNA recombination (GO:0045911)3.27959216
43positive regulation of cell fate commitment (GO:0010455)3.27640032
44positive regulation of B cell mediated immunity (GO:0002714)3.27116902
45positive regulation of immunoglobulin mediated immune response (GO:0002891)3.27116902
46regulation of chronic inflammatory response (GO:0002676)3.25494849
47pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.25052640
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24898919
49signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.24753262
50signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.24753262
51signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.24753262
52somatic recombination of immunoglobulin gene segments (GO:0016447)3.24036158
53intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23457272
54signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23457272
55RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.21881376
56regulation of cellular amino acid metabolic process (GO:0006521)3.21835246
57pyrimidine ribonucleotide biosynthetic process (GO:0009220)3.19291755
58UTP biosynthetic process (GO:0006228)3.18711233
59L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.16853180
60positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.16379348
61positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.16379348
62positive regulation of mitotic sister chromatid separation (GO:1901970)3.16379348
63chaperone-mediated protein transport (GO:0072321)3.15454665
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12162402
65signal transduction involved in cell cycle checkpoint (GO:0072395)3.11489794
66signal transduction involved in DNA integrity checkpoint (GO:0072401)3.11419541
67signal transduction involved in DNA damage checkpoint (GO:0072422)3.11419541
68rRNA methylation (GO:0031167)3.11244361
69positive regulation of defense response to virus by host (GO:0002230)3.11166085
70pyrimidine ribonucleotide metabolic process (GO:0009218)3.08788012
71C4-dicarboxylate transport (GO:0015740)3.05682439
72somatic diversification of immune receptors (GO:0002200)3.04279508
73pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.04089246
74UMP metabolic process (GO:0046049)3.04089246
75pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.04089246
76UMP biosynthetic process (GO:0006222)3.04089246
77DNA catabolic process, exonucleolytic (GO:0000738)3.03514609
78mitochondrial RNA metabolic process (GO:0000959)3.03291463
79tRNA aminoacylation for protein translation (GO:0006418)3.03187872
80tRNA aminoacylation (GO:0043039)3.02581685
81amino acid activation (GO:0043038)3.02581685
82regulation of protein homooligomerization (GO:0032462)2.98636883
83positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97154583
84somatic cell DNA recombination (GO:0016444)2.94903987
85somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.94903987
86protein-cofactor linkage (GO:0018065)2.93090441
87negative regulation of ligase activity (GO:0051352)2.92579942
88negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92579942
89ribosome biogenesis (GO:0042254)2.92507277
90positive regulation of activated T cell proliferation (GO:0042104)2.88883953
91positive regulation of ligase activity (GO:0051351)2.88037341
92positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.87814729
93IMP biosynthetic process (GO:0006188)2.87539446
94rRNA processing (GO:0006364)2.86715596
95pseudouridine synthesis (GO:0001522)2.84108977
96CTP metabolic process (GO:0046036)2.84009117
97CTP biosynthetic process (GO:0006241)2.84009117
98negative regulation of T cell apoptotic process (GO:0070233)2.82321738
99protein complex biogenesis (GO:0070271)2.80805625
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.80159492

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.00439877
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.49843619
3ZNF274_21170338_ChIP-Seq_K562_Hela3.68194500
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.48448193
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.46514165
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.30536407
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.88078425
8EWS_26573619_Chip-Seq_HEK293_Human2.75057260
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.74614554
10VDR_22108803_ChIP-Seq_LS180_Human2.72294470
11E2F7_22180533_ChIP-Seq_HELA_Human2.57119033
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55761589
13VDR_23849224_ChIP-Seq_CD4+_Human2.51316045
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.51106570
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.50571676
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.41016192
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33800704
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15023947
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.08084533
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04607549
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.02487436
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90339177
23FOXP3_21729870_ChIP-Seq_TREG_Human1.89253297
24MYC_18940864_ChIP-ChIP_HL60_Human1.87778070
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.86119128
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.85188398
27DCP1A_22483619_ChIP-Seq_HELA_Human1.81988355
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.80655598
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80386797
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.76945886
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75510848
32TAF15_26573619_Chip-Seq_HEK293_Human1.71924065
33ELK1_19687146_ChIP-ChIP_HELA_Human1.67373654
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67260419
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66361324
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64948123
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64374772
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.61389907
39FUS_26573619_Chip-Seq_HEK293_Human1.57130181
40TP53_22573176_ChIP-Seq_HFKS_Human1.56309755
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54528328
42BCAT_22108803_ChIP-Seq_LS180_Human1.53373084
43P300_19829295_ChIP-Seq_ESCs_Human1.52532393
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45023043
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42266564
46CBP_20019798_ChIP-Seq_JUKART_Human1.42266564
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40970924
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40950558
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35429336
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35005433
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34059075
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33259710
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32274389
54IRF1_19129219_ChIP-ChIP_H3396_Human1.32130860
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29292474
56TTF2_22483619_ChIP-Seq_HELA_Human1.27028538
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22707260
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22603645
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21214220
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21188451
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20964208
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19991800
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17911882
64IGF1R_20145208_ChIP-Seq_DFB_Human1.16823651
65GATA3_26560356_Chip-Seq_TH2_Human1.14758278
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12189789
67NANOG_19829295_ChIP-Seq_ESCs_Human1.12172857
68SOX2_19829295_ChIP-Seq_ESCs_Human1.12172857
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10130688
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08899427
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08143830
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07560140
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.07438751
74GBX2_23144817_ChIP-Seq_PC3_Human1.05394995
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97893729
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.97476448
77MYC_19829295_ChIP-Seq_ESCs_Human0.95766601
78GABP_19822575_ChIP-Seq_HepG2_Human0.94937509
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94351547
80EZH2_27294783_Chip-Seq_NPCs_Mouse0.94159904
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93900236
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93839081
83KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92631039
84YY1_21170310_ChIP-Seq_MESCs_Mouse0.91908408
85ER_23166858_ChIP-Seq_MCF-7_Human0.91611966
86IRF8_21731497_ChIP-ChIP_J774_Mouse0.89735258
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88701174
88CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.87797706
89PRDM14_20953172_ChIP-Seq_ESCs_Human0.87559652
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.86132396
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86132396
92TCF4_22108803_ChIP-Seq_LS180_Human0.85984039
93NCOR_22424771_ChIP-Seq_293T_Human0.85209050
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83787173
95PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.83529553
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83399209
97HOXB7_26014856_ChIP-Seq_BT474_Human0.82589975
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81972035
99E2F1_18555785_ChIP-Seq_MESCs_Mouse0.81169607
100P300_18555785_Chip-Seq_ESCs_Mouse0.81159395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction5.27045952
2MP0001835_abnormal_antigen_presentation3.93454132
3MP0000516_abnormal_urinary_system3.68437418
4MP0005367_renal/urinary_system_phenotyp3.68437418
5MP0003300_gastrointestinal_ulcer3.33672831
6MP0000465_gastrointestinal_hemorrhage2.69505006
7MP0008058_abnormal_DNA_repair2.66535475
8MP0003950_abnormal_plasma_membrane2.55693730
9MP0010094_abnormal_chromosome_stability2.28650776
10MP0008877_abnormal_DNA_methylation2.25393070
11MP0008875_abnormal_xenobiotic_pharmacok2.23508797
12MP0008057_abnormal_DNA_replication2.23267824
13MP0001501_abnormal_sleep_pattern2.11831156
14MP0003693_abnormal_embryo_hatching1.96556189
15MP0003718_maternal_effect1.92617244
16MP0005410_abnormal_fertilization1.84289965
17MP0001661_extended_life_span1.80292599
18MP0004742_abnormal_vestibular_system1.79987331
19MP0001853_heart_inflammation1.78459752
20MP0010234_abnormal_vibrissa_follicle1.75645165
21MP0004885_abnormal_endolymph1.74895042
22MP0003786_premature_aging1.72555525
23MP0001529_abnormal_vocalization1.70351604
24MP0009053_abnormal_anal_canal1.63823648
25MP0004957_abnormal_blastocyst_morpholog1.61515876
26MP0000685_abnormal_immune_system1.60389069
27MP0002102_abnormal_ear_morphology1.51221358
28MP0000604_amyloidosis1.49578894
29MP0002006_tumorigenesis1.47534807
30MP0003656_abnormal_erythrocyte_physiolo1.44567964
31MP0002751_abnormal_autonomic_nervous1.42782407
32MP0005671_abnormal_response_to1.35979961
33MP0001968_abnormal_touch/_nociception1.33946632
34MP0003567_abnormal_fetal_cardiomyocyte1.33373284
35MP0001905_abnormal_dopamine_level1.32380621
36MP0003806_abnormal_nucleotide_metabolis1.31898887
37MP0001800_abnormal_humoral_immune1.31333808
38MP0005551_abnormal_eye_electrophysiolog1.28884560
39MP0000703_abnormal_thymus_morphology1.27114959
40MP0005387_immune_system_phenotype1.26730113
41MP0001790_abnormal_immune_system1.26730113
42MP0006072_abnormal_retinal_apoptosis1.26056130
43MP0000537_abnormal_urethra_morphology1.24456420
44MP0009745_abnormal_behavioral_response1.22776980
45MP0005379_endocrine/exocrine_gland_phen1.22289090
46MP0009785_altered_susceptibility_to1.22015131
47MP0000538_abnormal_urinary_bladder1.19430323
48MP0002148_abnormal_hypersensitivity_rea1.17884309
49MP0003077_abnormal_cell_cycle1.14551343
50MP0008007_abnormal_cellular_replicative1.13542401
51MP0002166_altered_tumor_susceptibility1.12605890
52MP0004270_analgesia1.09555439
53MP0001177_atelectasis1.04677328
54MP0002210_abnormal_sex_determination1.04453638
55MP0006292_abnormal_olfactory_placode1.02335161
56MP0000689_abnormal_spleen_morphology1.01254783
57MP0002160_abnormal_reproductive_system1.00330961
58MP0005646_abnormal_pituitary_gland0.99838391
59MP0002272_abnormal_nervous_system0.99824400
60MP0002722_abnormal_immune_system0.97723009
61MP0008789_abnormal_olfactory_epithelium0.95913290
62MP0002736_abnormal_nociception_after0.95310234
63MP0002398_abnormal_bone_marrow0.93673735
64MP0005389_reproductive_system_phenotype0.90761183
65MP0005645_abnormal_hypothalamus_physiol0.89648851
66MP0001919_abnormal_reproductive_system0.87403256
67MP0006036_abnormal_mitochondrial_physio0.86587931
68MP0009333_abnormal_splenocyte_physiolog0.85051178
69MP0001929_abnormal_gametogenesis0.82099147
70MP0001764_abnormal_homeostasis0.81805742
71MP0008770_decreased_survivor_rate0.81424379
72MP0000427_abnormal_hair_cycle0.79901353
73MP0006035_abnormal_mitochondrial_morpho0.77925490
74MP0001119_abnormal_female_reproductive0.76984805
75MP0003633_abnormal_nervous_system0.76460385
76MP0001727_abnormal_embryo_implantation0.76391172
77MP0008932_abnormal_embryonic_tissue0.75436806
78MP0003698_abnormal_male_reproductive0.74844055
79MP0003186_abnormal_redox_activity0.74656174
80MP0010368_abnormal_lymphatic_system0.72644415
81MP0002429_abnormal_blood_cell0.72357851
82MP0002723_abnormal_immune_serum0.71132874
83MP0008872_abnormal_physiological_respon0.70736308
84MP0001486_abnormal_startle_reflex0.70282625
85MP0003878_abnormal_ear_physiology0.67768774
86MP0005377_hearing/vestibular/ear_phenot0.67768774
87MP0005332_abnormal_amino_acid0.67615544
88MP0005000_abnormal_immune_tolerance0.66504286
89MP0002452_abnormal_antigen_presenting0.65794623
90MP0009697_abnormal_copulation0.65765241
91MP0000372_irregular_coat_pigmentation0.65513744
92MP0002572_abnormal_emotion/affect_behav0.64799058
93MP0003936_abnormal_reproductive_system0.64645370
94MP0000716_abnormal_immune_system0.64556523
95MP0005075_abnormal_melanosome_morpholog0.64345705
96MP0005266_abnormal_metabolism0.63943258
97MP0002090_abnormal_vision0.63746381
98MP0002069_abnormal_eating/drinking_beha0.63392721
99MP0000653_abnormal_sex_gland0.63127857
100MP0010307_abnormal_tumor_latency0.62783471

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.12720306
2Increased IgM level (HP:0003496)4.88855212
3Lipid accumulation in hepatocytes (HP:0006561)3.87664570
4IgG deficiency (HP:0004315)3.85881816
5Neoplasm of the adrenal cortex (HP:0100641)3.70847966
6Increased hepatocellular lipid droplets (HP:0006565)3.54037162
7Type 2 muscle fiber atrophy (HP:0003554)3.51354630
8Absent rod-and cone-mediated responses on ERG (HP:0007688)3.37858698
9Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.26687239
10Progressive macrocephaly (HP:0004481)3.26664289
11Renal cortical cysts (HP:0000803)3.18434414
12Muscle fiber atrophy (HP:0100295)3.15949338
13Abnormality of the labia minora (HP:0012880)3.10907174
14Abnormality of the renal cortex (HP:0011035)3.07416111
15Squamous cell carcinoma (HP:0002860)3.04981730
16Conjunctival hamartoma (HP:0100780)2.96498302
17IgA deficiency (HP:0002720)2.95749694
18Increased CSF lactate (HP:0002490)2.90534956
193-Methylglutaconic aciduria (HP:0003535)2.90313085
20Increased serum lactate (HP:0002151)2.84418141
21Dyschromatopsia (HP:0007641)2.82463765
22Abnormality of T cell physiology (HP:0011840)2.74959051
23Acute necrotizing encephalopathy (HP:0006965)2.70765519
24Neoplasm of the adrenal gland (HP:0100631)2.66751265
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.59296960
26Cutaneous melanoma (HP:0012056)2.56171300
27Nephronophthisis (HP:0000090)2.53962641
28Aqueductal stenosis (HP:0002410)2.53830502
29Thyroiditis (HP:0100646)2.51394830
30Molar tooth sign on MRI (HP:0002419)2.51170694
31Abnormality of midbrain morphology (HP:0002418)2.51170694
32Chronic sinusitis (HP:0011109)2.50947099
33Abnormal rod and cone electroretinograms (HP:0008323)2.49269572
34Mitochondrial inheritance (HP:0001427)2.49182733
35Progressive microcephaly (HP:0000253)2.47271096
36Duplicated collecting system (HP:0000081)2.40452900
37Abnormal mitochondria in muscle tissue (HP:0008316)2.38806036
38Renal Fanconi syndrome (HP:0001994)2.37383196
39Abolished electroretinogram (ERG) (HP:0000550)2.37085256
40Cerebral edema (HP:0002181)2.35662889
41Cone-rod dystrophy (HP:0000548)2.26596660
42Abnormality of B cell number (HP:0010975)2.26039686
43Absent thumb (HP:0009777)2.25992442
44Elevated erythrocyte sedimentation rate (HP:0003565)2.25876347
45Acute encephalopathy (HP:0006846)2.21632245
46Abnormality of the renal collecting system (HP:0004742)2.20172342
47B lymphocytopenia (HP:0010976)2.20001019
48Poor suck (HP:0002033)2.17546207
49Abnormality of the heme biosynthetic pathway (HP:0010472)2.17329048
50Abnormality of the renal medulla (HP:0100957)2.16587196
51Abnormality of the pons (HP:0007361)2.12116251
52Adactyly (HP:0009776)2.11371338
53Poor head control (HP:0002421)2.11346697
54Abnormality of methionine metabolism (HP:0010901)2.10155219
55Abnormality of alanine metabolism (HP:0010916)2.08917830
56Hyperalaninemia (HP:0003348)2.08917830
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08917830
58Poor speech (HP:0002465)2.08822137
59Optic disc pallor (HP:0000543)2.08695477
60Exertional dyspnea (HP:0002875)2.07926456
61Respiratory difficulties (HP:0002880)2.07566775
62Hamartoma of the eye (HP:0010568)2.06781323
63Increased muscle lipid content (HP:0009058)2.05207918
64Ureteral duplication (HP:0000073)2.04818787
65Abnormality of the nasal septum (HP:0000419)2.02802847
66Increased intramyocellular lipid droplets (HP:0012240)2.02754415
67Pancreatic cysts (HP:0001737)2.00816082
68Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00203308
69Abnormality of T cells (HP:0002843)1.96045741
70Hypomagnesemia (HP:0002917)1.95547615
71Hepatocellular necrosis (HP:0001404)1.95325452
72Congenital, generalized hypertrichosis (HP:0004540)1.93804196
73Abnormal number of incisors (HP:0011064)1.92758830
74Pancytopenia (HP:0001876)1.91326559
75Cleft eyelid (HP:0000625)1.91304779
76Chronic hepatic failure (HP:0100626)1.91248896
77Amyotrophic lateral sclerosis (HP:0007354)1.90261567
78Meningioma (HP:0002858)1.87186565
79Pigmentary retinal degeneration (HP:0001146)1.86887012
80Respiratory failure (HP:0002878)1.86087888
81Aplasia/Hypoplasia of the uvula (HP:0010293)1.84603015
82Meckel diverticulum (HP:0002245)1.82883951
83Macular degeneration (HP:0000608)1.82711315
84Polyuria (HP:0000103)1.81811904
85Lethargy (HP:0001254)1.81336216
86Basal cell carcinoma (HP:0002671)1.81009112
87Furrowed tongue (HP:0000221)1.80434067
88Vitreoretinal degeneration (HP:0000655)1.79479350
89Atrophy/Degeneration involving motor neurons (HP:0007373)1.78338096
90Abnormality of the parathyroid morphology (HP:0011766)1.78118293
91Colon cancer (HP:0003003)1.77291972
92Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76623274
93Neutropenia (HP:0001875)1.75421144
94Patellar aplasia (HP:0006443)1.75101658
95Amblyopia (HP:0000646)1.74728281
96Abnormality of the preputium (HP:0100587)1.74551796
97Exercise intolerance (HP:0003546)1.72958446
98Azoospermia (HP:0000027)1.72463481
99Abnormality of the ileum (HP:0001549)1.70533835
100Constricted visual fields (HP:0001133)1.69691515

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.28588532
2TSSK63.74956523
3FGFR23.53801943
4MST43.27897975
5WNK33.15552991
6EIF2AK12.81383266
7SRPK12.66469914
8TXK2.50707325
9EIF2AK32.46284098
10SCYL21.99552877
11PLK31.98399945
12TLK11.97550968
13BUB11.89742013
14ZAK1.89405107
15NEK11.83186837
16PLK41.72387866
17ADRBK21.66262293
18PINK11.65017365
19VRK21.61826127
20NME11.45325110
21KDR1.40410070
22STK391.29232958
23VRK11.23614887
24ALK1.23097822
25CCNB11.23007192
26PLK21.20979110
27TNIK1.20587439
28EIF2AK21.18250261
29PLK11.17672344
30FGFR31.17147614
31GRK11.16829154
32MAP4K11.11877571
33PAK41.09776772
34RPS6KA41.08955085
35MKNK21.07378289
36DYRK31.06611457
37TTK1.04700893
38NME21.02517580
39TAOK31.00171366
40ATR0.98566576
41NUAK10.96235189
42IKBKE0.93491541
43OXSR10.93293412
44CDK30.93048705
45MAP3K120.90561723
46IKBKB0.87865091
47TRIM280.87320612
48SIK30.85408832
49PHKG10.84455670
50PHKG20.84455670
51TEC0.76490353
52PASK0.71892104
53RPS6KA50.69499448
54WNK40.65848463
55BMPR20.65189180
56TAF10.62573589
57CHEK10.59861341
58BTK0.59737338
59MAP4K20.57208122
60DAPK10.52470880
61INSRR0.51933144
62PKN10.51807125
63MKNK10.51713350
64STK40.50021233
65ITK0.48134177
66CSNK1A1L0.46445863
67CDC70.46135960
68FGFR10.46076211
69ATM0.45063754
70MAP3K40.44368767
71AURKB0.41589764
72CSNK2A10.41039726
73WEE10.40752004
74MAP3K110.39681609
75CSNK2A20.39601086
76CAMK40.39580208
77DYRK20.37361881
78BCR0.36118560
79PTK2B0.35538173
80PAK30.35323928
81CSNK1G30.34899594
82LCK0.34110867
83PRKCE0.31994648
84PRKCZ0.31639964
85PRKCB0.31338018
86GRK70.30057839
87CSNK1G10.29777756
88CAMK2A0.29234428
89CSNK1A10.28987315
90TRPM70.27590936
91PRKCG0.26471943
92CDK10.26168220
93LYN0.24790030
94CAMK10.24420749
95CSNK1G20.24123628
96BCKDK0.23781068
97TAOK20.23055589
98SYK0.22979990
99PRKDC0.22894067
100CSNK1E0.22521684

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.92998960
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.06980740
3Mismatch repair_Homo sapiens_hsa034302.91131011
4Asthma_Homo sapiens_hsa053102.68052097
5DNA replication_Homo sapiens_hsa030302.54181731
6Allograft rejection_Homo sapiens_hsa053302.47655703
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33128557
8Autoimmune thyroid disease_Homo sapiens_hsa053202.26551625
9RNA polymerase_Homo sapiens_hsa030202.22624117
10Basal transcription factors_Homo sapiens_hsa030222.20981614
11RNA degradation_Homo sapiens_hsa030182.16022617
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.13138450
13Primary immunodeficiency_Homo sapiens_hsa053402.11229183
14Protein export_Homo sapiens_hsa030602.00552664
15Oxidative phosphorylation_Homo sapiens_hsa001901.99094074
16Homologous recombination_Homo sapiens_hsa034401.92090599
17Parkinsons disease_Homo sapiens_hsa050121.79127856
18RNA transport_Homo sapiens_hsa030131.78027476
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.76764478
20One carbon pool by folate_Homo sapiens_hsa006701.75434344
21Type I diabetes mellitus_Homo sapiens_hsa049401.75082463
22Pyrimidine metabolism_Homo sapiens_hsa002401.67467645
23Spliceosome_Homo sapiens_hsa030401.64659543
24Non-homologous end-joining_Homo sapiens_hsa034501.58611931
25Fanconi anemia pathway_Homo sapiens_hsa034601.57955766
26Nucleotide excision repair_Homo sapiens_hsa034201.56687672
27Base excision repair_Homo sapiens_hsa034101.52705485
28Graft-versus-host disease_Homo sapiens_hsa053321.45595450
29Caffeine metabolism_Homo sapiens_hsa002321.42051976
30Vitamin B6 metabolism_Homo sapiens_hsa007501.35150247
31Purine metabolism_Homo sapiens_hsa002301.33002443
32Propanoate metabolism_Homo sapiens_hsa006401.32013025
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27502439
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.24255433
35Linoleic acid metabolism_Homo sapiens_hsa005911.21529595
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21162215
37Huntingtons disease_Homo sapiens_hsa050161.20426037
38Ribosome_Homo sapiens_hsa030101.15273584
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15271160
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10616780
41Nicotine addiction_Homo sapiens_hsa050331.03080990
42Hematopoietic cell lineage_Homo sapiens_hsa046401.01270467
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00497678
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95202602
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95093001
46Taste transduction_Homo sapiens_hsa047420.94116549
47Antigen processing and presentation_Homo sapiens_hsa046120.91519893
48Phototransduction_Homo sapiens_hsa047440.89403416
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.87971760
50Olfactory transduction_Homo sapiens_hsa047400.87289784
51Selenocompound metabolism_Homo sapiens_hsa004500.86308542
52Alzheimers disease_Homo sapiens_hsa050100.85436749
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83580257
54T cell receptor signaling pathway_Homo sapiens_hsa046600.76730697
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75362730
56Sulfur metabolism_Homo sapiens_hsa009200.74976412
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.68574991
58Rheumatoid arthritis_Homo sapiens_hsa053230.68266982
59Collecting duct acid secretion_Homo sapiens_hsa049660.67883143
60Systemic lupus erythematosus_Homo sapiens_hsa053220.63826536
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.61439573
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59671795
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58064573
64mRNA surveillance pathway_Homo sapiens_hsa030150.57982120
65Cardiac muscle contraction_Homo sapiens_hsa042600.57970172
66Glutamatergic synapse_Homo sapiens_hsa047240.57355677
67Morphine addiction_Homo sapiens_hsa050320.55815199
68Measles_Homo sapiens_hsa051620.54844113
69Folate biosynthesis_Homo sapiens_hsa007900.54524813
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.52563128
71Fatty acid elongation_Homo sapiens_hsa000620.50066211
72Pyruvate metabolism_Homo sapiens_hsa006200.49273344
73Peroxisome_Homo sapiens_hsa041460.48796189
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46534029
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46247157
76Ether lipid metabolism_Homo sapiens_hsa005650.45596022
77Arachidonic acid metabolism_Homo sapiens_hsa005900.44564652
78Metabolic pathways_Homo sapiens_hsa011000.42649300
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42394160
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40184642
81Regulation of autophagy_Homo sapiens_hsa041400.37637009
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37429958
83Epstein-Barr virus infection_Homo sapiens_hsa051690.36217139
84Butanoate metabolism_Homo sapiens_hsa006500.35000453
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.34950171
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31892487
87Fatty acid biosynthesis_Homo sapiens_hsa000610.30390719
88HTLV-I infection_Homo sapiens_hsa051660.28940028
89Nitrogen metabolism_Homo sapiens_hsa009100.28311687
90p53 signaling pathway_Homo sapiens_hsa041150.27967874
91Glutathione metabolism_Homo sapiens_hsa004800.27424258
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27117843
93Tryptophan metabolism_Homo sapiens_hsa003800.26946778
94Cocaine addiction_Homo sapiens_hsa050300.24344901
95Fat digestion and absorption_Homo sapiens_hsa049750.23593057
96GABAergic synapse_Homo sapiens_hsa047270.23213161
97Circadian rhythm_Homo sapiens_hsa047100.22051959
98Retinol metabolism_Homo sapiens_hsa008300.20086476
99Legionellosis_Homo sapiens_hsa051340.19525836
100Herpes simplex infection_Homo sapiens_hsa051680.19433359

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