RANP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)8.54244126
2cytidine metabolic process (GO:0046087)8.34144292
3cytidine catabolic process (GO:0006216)8.34144292
4cytidine deamination (GO:0009972)8.34144292
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.01332784
6pyrimidine ribonucleoside catabolic process (GO:0046133)7.19876970
7proteasome assembly (GO:0043248)4.98383357
8negative regulation by host of viral transcription (GO:0043922)4.54113801
9Arp2/3 complex-mediated actin nucleation (GO:0034314)4.51845911
10regulation of chronic inflammatory response (GO:0002676)4.49836363
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.48220682
12regulation of cellular amino acid metabolic process (GO:0006521)4.41036021
13negative regulation of T cell apoptotic process (GO:0070233)4.38344620
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.30680660
15regulation of regulatory T cell differentiation (GO:0045589)4.26788949
16DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.19268123
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.17292845
18sequestering of actin monomers (GO:0042989)4.11957931
19negative regulation of ligase activity (GO:0051352)4.10571414
20negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.10571414
21signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.06815314
22intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.06815314
23signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.04971369
24signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.04971369
25signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.04971369
26positive T cell selection (GO:0043368)4.02440558
27actin nucleation (GO:0045010)4.01961590
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.01272448
29cytolysis (GO:0019835)3.98858613
30positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.97165102
31positive regulation of natural killer cell mediated immunity (GO:0002717)3.93456544
32positive thymic T cell selection (GO:0045059)3.92905366
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.92584904
34ATP synthesis coupled proton transport (GO:0015986)3.92584904
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.89528841
36regulation of activation of Janus kinase activity (GO:0010533)3.86884367
37antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.86676613
38mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.85155675
39eosinophil chemotaxis (GO:0048245)3.83606244
40signal transduction involved in DNA damage checkpoint (GO:0072422)3.83536517
41signal transduction involved in DNA integrity checkpoint (GO:0072401)3.83536517
42signal transduction involved in cell cycle checkpoint (GO:0072395)3.80192256
43positive regulation of interleukin-8 secretion (GO:2000484)3.75021231
44T cell migration (GO:0072678)3.72212429
45positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.72118783
46respiratory electron transport chain (GO:0022904)3.64779832
47anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.63915712
48negative regulation of viral genome replication (GO:0045071)3.63076156
49macrophage chemotaxis (GO:0048246)3.62292425
50pyrimidine nucleoside catabolic process (GO:0046135)3.61700853
51electron transport chain (GO:0022900)3.58879733
52negative regulation of lymphocyte apoptotic process (GO:0070229)3.57526105
53positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.56636906
54positive regulation of tolerance induction (GO:0002645)3.53144908
55regulation of B cell receptor signaling pathway (GO:0050855)3.52925029
56protein neddylation (GO:0045116)3.49973991
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.49737801
58eosinophil migration (GO:0072677)3.48042720
59positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.46238405
60regulation of isotype switching to IgG isotypes (GO:0048302)3.43381334
61negative T cell selection (GO:0043383)3.43150696
62cellular response to interleukin-15 (GO:0071350)3.39378476
63regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.38918350
64regulation of natural killer cell mediated immunity (GO:0002715)3.38918350
65negative regulation of stress fiber assembly (GO:0051497)3.36123032
66regulation of T cell tolerance induction (GO:0002664)3.34770561
67establishment of protein localization to mitochondrial membrane (GO:0090151)3.32021466
68regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.30066549
69positive regulation of cell cycle arrest (GO:0071158)3.29501193
70positive regulation of ligase activity (GO:0051351)3.28474559
71positive regulation of T cell mediated cytotoxicity (GO:0001916)3.25087696
72positive regulation of calcium-mediated signaling (GO:0050850)3.25055206
73regulation of leukocyte mediated cytotoxicity (GO:0001910)3.24530883
74positive regulation of cell killing (GO:0031343)3.24478056
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.20008601
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.20008601
77DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.13684743
78regulation of cellular amine metabolic process (GO:0033238)3.13209299
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.11691123
80iron-sulfur cluster assembly (GO:0016226)3.09878212
81metallo-sulfur cluster assembly (GO:0031163)3.09878212
82antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.09691842
83deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.07474738
84response to interferon-beta (GO:0035456)3.05768164
85thymic T cell selection (GO:0045061)3.01702124
86protein complex biogenesis (GO:0070271)3.00488522
87positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.00061540
88regulation of ubiquitin-protein transferase activity (GO:0051438)2.99993838
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98313485
90regulation of T cell apoptotic process (GO:0070232)2.94497781
91chaperone-mediated protein transport (GO:0072321)2.92849809
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.91157013
93regulation of viral genome replication (GO:0045069)2.89699646
94positive regulation of T cell apoptotic process (GO:0070234)2.88311099
95regulation of interleukin-2 biosynthetic process (GO:0045076)2.88088305
96regulation of ligase activity (GO:0051340)2.87047229
97regulation of cell killing (GO:0031341)2.86369704
98positive regulation of lymphocyte migration (GO:2000403)2.84252475
99negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.83347337
100regulation of T cell receptor signaling pathway (GO:0050856)2.82290437

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.24772694
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human5.09309138
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.27493784
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.68415286
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.56567296
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.45481804
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.34855411
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.28520448
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.20146354
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.06951700
11VDR_23849224_ChIP-Seq_CD4+_Human2.66235455
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.65283995
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.56704823
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.55765630
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.54953774
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53907413
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41188294
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.25930401
19MYB_26560356_Chip-Seq_TH2_Human2.17176089
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.16886681
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09340637
22FOXP3_21729870_ChIP-Seq_TREG_Human2.06374098
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.02078167
24ELK1_19687146_ChIP-ChIP_HELA_Human1.99140236
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.97403919
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.94957800
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92136980
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82512697
29VDR_22108803_ChIP-Seq_LS180_Human1.71043714
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67221769
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67124630
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63208378
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59171295
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57743563
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54857379
36GATA3_27048872_Chip-Seq_THYMUS_Human1.54329109
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.54122826
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51476846
39GATA3_26560356_Chip-Seq_TH2_Human1.49971005
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45276321
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.44990045
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42821065
43HTT_18923047_ChIP-ChIP_STHdh_Human1.41605017
44PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.36799968
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.35843670
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35619332
47DCP1A_22483619_ChIP-Seq_HELA_Human1.34312207
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32948836
49TP53_22573176_ChIP-Seq_HFKS_Human1.32299906
50MYB_26560356_Chip-Seq_TH1_Human1.32230831
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30416263
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27759546
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25259073
54MYC_18940864_ChIP-ChIP_HL60_Human1.23790476
55ZNF274_21170338_ChIP-Seq_K562_Hela1.23420339
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.22764446
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.20590738
58GABP_19822575_ChIP-Seq_HepG2_Human1.20136222
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16223607
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13964119
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13368253
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13159689
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10629726
64TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10554625
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.08810002
66RUNX_20019798_ChIP-Seq_JUKART_Human1.07934167
67UTX_26944678_Chip-Seq_JUKART_Human1.07739569
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07118069
69MAF_26560356_Chip-Seq_TH2_Human1.05490475
70CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05128228
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02757803
72ERG_20517297_ChIP-Seq_VCAP_Human1.02049889
73FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01191849
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99836473
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99039729
76SPI1_23547873_ChIP-Seq_NB4_Human0.97149609
77STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95879186
78CIITA_25753668_ChIP-Seq_RAJI_Human0.95488248
79PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94948659
80NANOG_20526341_ChIP-Seq_ESCs_Human0.94861010
81TAF2_19829295_ChIP-Seq_ESCs_Human0.94709145
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93640683
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.93640683
84BCL6_27268052_Chip-Seq_Bcells_Human0.93482845
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92743262
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91687389
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91330704
88AR_20517297_ChIP-Seq_VCAP_Human0.90926102
89MAF_26560356_Chip-Seq_TH1_Human0.90744885
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89420900
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89378231
92GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89266798
93POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89188528
94NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87805882
95FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.87307788
96TTF2_22483619_ChIP-Seq_HELA_Human0.86298092
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85597318
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84936089
99CTCF_20526341_ChIP-Seq_ESCs_Human0.84212498
100GATA3_21878914_ChIP-Seq_MCF-7_Human0.83596958

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.10436422
2MP0001835_abnormal_antigen_presentation3.56726084
3MP0003763_abnormal_thymus_physiology3.39306852
4MP0009785_altered_susceptibility_to3.35566836
5MP0009333_abnormal_splenocyte_physiolog3.01919738
6MP0004147_increased_porphyrin_level2.89900179
7MP0001873_stomach_inflammation2.83008430
8MP0003786_premature_aging2.65604935
9MP0006082_CNS_inflammation2.53050393
10MP0005000_abnormal_immune_tolerance2.41873186
11MP0002102_abnormal_ear_morphology2.30811847
12MP0002166_altered_tumor_susceptibility2.21290844
13MP0001800_abnormal_humoral_immune2.17232559
14MP0003866_abnormal_defecation2.14259732
15MP0001790_abnormal_immune_system2.12699188
16MP0005387_immune_system_phenotype2.12699188
17MP0005025_abnormal_response_to2.12220710
18MP0000685_abnormal_immune_system2.11167218
19MP0002420_abnormal_adaptive_immunity2.09252351
20MP0002148_abnormal_hypersensitivity_rea2.04534321
21MP0001819_abnormal_immune_cell2.00396955
22MP0002723_abnormal_immune_serum1.99553352
23MP0002006_tumorigenesis1.86528600
24MP0002405_respiratory_system_inflammati1.80077773
25MP0005377_hearing/vestibular/ear_phenot1.69798989
26MP0003878_abnormal_ear_physiology1.69798989
27MP0003646_muscle_fatigue1.66998327
28MP0002398_abnormal_bone_marrow1.66653944
29MP0000716_abnormal_immune_system1.63496856
30MP0003806_abnormal_nucleotide_metabolis1.63488080
31MP0002452_abnormal_antigen_presenting1.58645684
32MP0001853_heart_inflammation1.57788579
33MP0000703_abnormal_thymus_morphology1.56694014
34MP0002722_abnormal_immune_system1.50256717
35MP0006072_abnormal_retinal_apoptosis1.48692739
36MP0000689_abnormal_spleen_morphology1.46491287
37MP0002933_joint_inflammation1.43231063
38MP0002277_abnormal_respiratory_mucosa1.41646370
39MP0001845_abnormal_inflammatory_respons1.40055504
40MP0003448_altered_tumor_morphology1.38194524
41MP0001905_abnormal_dopamine_level1.38099705
42MP0008875_abnormal_xenobiotic_pharmacok1.34133415
43MP0002429_abnormal_blood_cell1.32365000
44MP0005645_abnormal_hypothalamus_physiol1.30766736
45MP0003693_abnormal_embryo_hatching1.30687116
46MP0010155_abnormal_intestine_physiology1.30072794
47MP0001919_abnormal_reproductive_system1.25003954
48MP0001485_abnormal_pinna_reflex1.24894931
49MP0008872_abnormal_physiological_respon1.22899876
50MP0004957_abnormal_blastocyst_morpholog1.22132969
51MP0006036_abnormal_mitochondrial_physio1.19967751
52MP0008007_abnormal_cellular_replicative1.17130883
53MP0003137_abnormal_impulse_conducting1.15488370
54MP0004145_abnormal_muscle_electrophysio1.14773827
55MP0001661_extended_life_span1.14376919
56MP0002736_abnormal_nociception_after1.14152877
57MP0008058_abnormal_DNA_repair1.05711791
58MP0008995_early_reproductive_senescence1.03237874
59MP0009763_increased_sensitivity_to1.00367746
60MP0005389_reproductive_system_phenotype1.00318530
61MP0003436_decreased_susceptibility_to1.00247177
62MP0002419_abnormal_innate_immunity0.98569773
63MP0002019_abnormal_tumor_incidence0.97793714
64MP0005464_abnormal_platelet_physiology0.96229976
65MP0000372_irregular_coat_pigmentation0.94806833
66MP0003045_fibrosis0.93617850
67MP0002837_dystrophic_cardiac_calcinosis0.93533367
68MP0005551_abnormal_eye_electrophysiolog0.91630347
69MP0008469_abnormal_protein_level0.90110737
70MP0003195_calcinosis0.89575207
71MP0002138_abnormal_hepatobiliary_system0.89088820
72MP0005636_abnormal_mineral_homeostasis0.89035623
73MP0006035_abnormal_mitochondrial_morpho0.89033878
74MP0003880_abnormal_central_pattern0.88597076
75MP0002876_abnormal_thyroid_physiology0.88160906
76MP0002095_abnormal_skin_pigmentation0.87652650
77MP0004742_abnormal_vestibular_system0.87013706
78MP0002163_abnormal_gland_morphology0.85939102
79MP0008789_abnormal_olfactory_epithelium0.85421087
80MP0006054_spinal_hemorrhage0.82534225
81MP0001968_abnormal_touch/_nociception0.81508960
82MP0010386_abnormal_urinary_bladder0.79508970
83MP0001188_hyperpigmentation0.79260939
84MP0005166_decreased_susceptibility_to0.78347266
85MP0009764_decreased_sensitivity_to0.78346218
86MP0005083_abnormal_biliary_tract0.78272620
87MP0009379_abnormal_foot_pigmentation0.78050371
88MP0003011_delayed_dark_adaptation0.77105031
89MP0004134_abnormal_chest_morphology0.76983585
90MP0005084_abnormal_gallbladder_morpholo0.76825402
91MP0003567_abnormal_fetal_cardiomyocyte0.76610320
92MP0001119_abnormal_female_reproductive0.75711919
93MP0001501_abnormal_sleep_pattern0.75055139
94MP0001542_abnormal_bone_strength0.72878176
95MP0005075_abnormal_melanosome_morpholog0.71624469
96MP0002693_abnormal_pancreas_physiology0.71518594
97MP0008877_abnormal_DNA_methylation0.69225820
98MP0001727_abnormal_embryo_implantation0.67457256
99MP0003111_abnormal_nucleus_morphology0.65836094
100MP0005310_abnormal_salivary_gland0.65665085

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.39740906
2T lymphocytopenia (HP:0005403)4.68242927
3Mitochondrial inheritance (HP:0001427)4.54869697
4IgG deficiency (HP:0004315)4.54441152
5Acute necrotizing encephalopathy (HP:0006965)4.43744539
6Abnormality of T cell number (HP:0011839)4.34887314
7Abnormal mitochondria in muscle tissue (HP:0008316)4.26144516
8Elevated erythrocyte sedimentation rate (HP:0003565)4.09588134
9Hepatocellular necrosis (HP:0001404)3.97848841
10Increased IgM level (HP:0003496)3.91397013
11Hypoproteinemia (HP:0003075)3.90300612
12Increased CSF lactate (HP:0002490)3.86024525
13Increased hepatocellular lipid droplets (HP:0006565)3.84413096
14Increased intramyocellular lipid droplets (HP:0012240)3.78228906
15Acute encephalopathy (HP:0006846)3.73002911
16Renal Fanconi syndrome (HP:0001994)3.69274992
17Progressive macrocephaly (HP:0004481)3.61355012
18Hepatic necrosis (HP:0002605)3.53926259
19Severe combined immunodeficiency (HP:0004430)3.50971215
20Autoimmune hemolytic anemia (HP:0001890)3.41703648
21Stomatitis (HP:0010280)3.40506235
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.38025164
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.38025164
24Lipid accumulation in hepatocytes (HP:0006561)3.28706969
25Abnormality of T cells (HP:0002843)3.19121521
26Cerebral edema (HP:0002181)3.14847330
27B lymphocytopenia (HP:0010976)3.05216464
28Increased muscle lipid content (HP:0009058)3.04683080
29Pancytopenia (HP:0001876)2.99986944
303-Methylglutaconic aciduria (HP:0003535)2.97742219
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.95765899
32Abnormality of B cell number (HP:0010975)2.94209944
33Increased serum lactate (HP:0002151)2.87046451
34Combined immunodeficiency (HP:0005387)2.85690180
35Generalized aminoaciduria (HP:0002909)2.82735596
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.76784691
37Exertional dyspnea (HP:0002875)2.75113125
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.72101715
39IgM deficiency (HP:0002850)2.71113493
40Lactic acidosis (HP:0003128)2.68546110
41Abnormality of the prostate (HP:0008775)2.68253330
42Thyroiditis (HP:0100646)2.66960367
43Pancreatic cysts (HP:0001737)2.53495841
44Exercise intolerance (HP:0003546)2.47873296
45Congenital stationary night blindness (HP:0007642)2.43748837
46Abnormality of eosinophils (HP:0001879)2.42359585
47Encephalitis (HP:0002383)2.42317254
48Lymphopenia (HP:0001888)2.39840936
49Methylmalonic aciduria (HP:0012120)2.37592548
50Chronic diarrhea (HP:0002028)2.28389494
51Optic disc pallor (HP:0000543)2.28183362
52Hypoalbuminemia (HP:0003073)2.27817503
53Abnormal albumin level (HP:0012116)2.27817503
54Respiratory failure (HP:0002878)2.27063680
55Lethargy (HP:0001254)2.22068045
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.18649540
57Hypoplasia of the thymus (HP:0000778)2.16696882
58Type I transferrin isoform profile (HP:0003642)2.14607782
59Abnormal rod and cone electroretinograms (HP:0008323)2.12673509
60Gastrointestinal infarctions (HP:0005244)2.10730125
61Recurrent bronchitis (HP:0002837)2.10246419
62Methylmalonic acidemia (HP:0002912)2.07179611
63Acute hepatic failure (HP:0006554)2.06991440
64Eosinophilia (HP:0001880)2.06514416
65True hermaphroditism (HP:0010459)2.04604331
66Hyperglycinemia (HP:0002154)2.01532772
67Dicarboxylic aciduria (HP:0003215)2.00844657
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00844657
69Severe visual impairment (HP:0001141)2.00826816
70Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00371042
71Meningitis (HP:0001287)1.98734645
72Abnormality of midbrain morphology (HP:0002418)1.95575173
73Molar tooth sign on MRI (HP:0002419)1.95575173
74Amyotrophic lateral sclerosis (HP:0007354)1.95481147
75Pendular nystagmus (HP:0012043)1.93829465
76Abnormal delayed hypersensitivity skin test (HP:0002963)1.92318042
77Aplasia/hypoplasia of the uterus (HP:0008684)1.91062689
78Abnormality of renal resorption (HP:0011038)1.88752127
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87178418
80Abnormality of alanine metabolism (HP:0010916)1.87178418
81Hyperalaninemia (HP:0003348)1.87178418
82Abolished electroretinogram (ERG) (HP:0000550)1.85890570
83Abnormality of T cell physiology (HP:0011840)1.85480139
84Glycosuria (HP:0003076)1.84550070
85Abnormality of urine glucose concentration (HP:0011016)1.84550070
86Pancreatic fibrosis (HP:0100732)1.83360405
87Respiratory difficulties (HP:0002880)1.83166233
88Oral leukoplakia (HP:0002745)1.82885708
89Gangrene (HP:0100758)1.82633821
90Decreased central vision (HP:0007663)1.82436985
91Leukodystrophy (HP:0002415)1.81553423
92Attenuation of retinal blood vessels (HP:0007843)1.80116656
93Cerebral palsy (HP:0100021)1.79303102
94Agammaglobulinemia (HP:0004432)1.78501581
95Bronchitis (HP:0012387)1.78381045
96Renal cortical cysts (HP:0000803)1.78145800
97Joint swelling (HP:0001386)1.77457193
98Lymphoma (HP:0002665)1.76850699
99Congenital, generalized hypertrichosis (HP:0004540)1.76489149
100Emotional lability (HP:0000712)1.73912209

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK26.14412440
2KDR5.78583189
3TXK5.19724140
4BUB13.62272743
5BCKDK3.54163682
6VRK23.45659764
7TESK12.57605539
8MAP4K12.44110754
9MST42.12171508
10LIMK12.04266417
11ITK1.86905481
12ZAK1.66698174
13VRK11.55174244
14ADRBK21.52769315
15GRK11.50200905
16EIF2AK31.37775393
17MAP3K121.36234920
18TAOK31.34821808
19NUAK11.33709469
20TEC1.32946969
21MAPKAPK31.30583293
22SRPK11.30040804
23SCYL21.27880515
24MUSK1.24768316
25NME11.21725162
26EIF2AK11.10529512
27DAPK11.10089005
28MAP4K21.06823474
29TLK11.03461029
30PRKCQ1.03004272
31SYK1.01597278
32TRIM280.96081671
33CSK0.94958044
34WNK40.91778418
35MAP3K110.90968283
36RPS6KA40.88786785
37LCK0.88446876
38CSNK1G30.87713787
39GRK70.86754154
40BTK0.85339237
41GRK60.84060098
42CDC70.82301406
43FES0.77087280
44STK160.76373783
45RPS6KA50.74213345
46ZAP700.73100774
47MAP2K70.71862796
48OXSR10.70207876
49PAK40.69974567
50CSNK1A1L0.68152312
51STK390.67190330
52MYLK0.65985363
53PLK40.65140862
54CSNK1G10.63201277
55TNK20.63155570
56NME20.62468604
57BCR0.62411154
58LYN0.58710889
59AURKA0.56704165
60CSNK1G20.55467683
61INSRR0.55406242
62WNK30.52224692
63PIM20.50763122
64TIE10.50095261
65ATR0.49745622
66NEK10.48051172
67PLK10.47462358
68IKBKB0.46509697
69IKBKE0.43852406
70ERBB30.42772328
71MAP2K60.42556863
72PLK30.41356368
73CDK190.41329673
74TBK10.40568939
75CSF1R0.39818270
76OBSCN0.39491844
77TSSK60.38706163
78PIK3CG0.38570466
79GRK50.38494374
80PAK10.37949241
81CSNK2A10.37941059
82IGF1R0.36965348
83JAK30.35922888
84AURKB0.34462781
85ROCK10.33767882
86PINK10.33725038
87FYN0.32776361
88CSNK1A10.32137627
89INSR0.30317530
90CSNK2A20.29943151
91STK100.29105838
92PIK3CA0.28826912
93FRK0.28602212
94PRKCA0.27718831
95EIF2AK20.25297152
96CAMK2A0.23110701
97PIM10.22829942
98TAF10.22622450
99PRKACA0.22343640
100ADRBK10.22237780

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.93328016
2Primary immunodeficiency_Homo sapiens_hsa053404.86141635
3Oxidative phosphorylation_Homo sapiens_hsa001903.64466433
4Parkinsons disease_Homo sapiens_hsa050123.18568935
5RNA polymerase_Homo sapiens_hsa030202.53493332
6Autoimmune thyroid disease_Homo sapiens_hsa053202.43974890
7Protein export_Homo sapiens_hsa030602.42213514
8Graft-versus-host disease_Homo sapiens_hsa053322.28706690
9Antigen processing and presentation_Homo sapiens_hsa046122.27909720
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.26760667
11Allograft rejection_Homo sapiens_hsa053302.21014725
12Hematopoietic cell lineage_Homo sapiens_hsa046402.16083328
13Alzheimers disease_Homo sapiens_hsa050102.11146699
14Huntingtons disease_Homo sapiens_hsa050162.00531953
15Ribosome_Homo sapiens_hsa030101.94872044
16T cell receptor signaling pathway_Homo sapiens_hsa046601.89434026
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.86956629
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.82884983
19Type I diabetes mellitus_Homo sapiens_hsa049401.68735937
20DNA replication_Homo sapiens_hsa030301.66134567
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65874253
22Cardiac muscle contraction_Homo sapiens_hsa042601.40500480
23Homologous recombination_Homo sapiens_hsa034401.38524555
24Rheumatoid arthritis_Homo sapiens_hsa053231.35938035
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35809288
26Pyrimidine metabolism_Homo sapiens_hsa002401.33735622
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33237076
28Mismatch repair_Homo sapiens_hsa034301.18965464
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16994122
30Asthma_Homo sapiens_hsa053101.15607828
31RNA degradation_Homo sapiens_hsa030181.11296304
32Measles_Homo sapiens_hsa051621.10933830
33One carbon pool by folate_Homo sapiens_hsa006701.09560854
34Phototransduction_Homo sapiens_hsa047441.07481703
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05115197
36Nucleotide excision repair_Homo sapiens_hsa034201.03000481
37Spliceosome_Homo sapiens_hsa030401.02934371
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.01617050
39Purine metabolism_Homo sapiens_hsa002300.98045757
40Propanoate metabolism_Homo sapiens_hsa006400.98015457
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94782814
42Intestinal immune network for IgA production_Homo sapiens_hsa046720.94535149
43Salmonella infection_Homo sapiens_hsa051320.93238983
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85066938
45Shigellosis_Homo sapiens_hsa051310.84851605
46Fanconi anemia pathway_Homo sapiens_hsa034600.84573754
47Peroxisome_Homo sapiens_hsa041460.82471836
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82462098
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79107377
50Basal transcription factors_Homo sapiens_hsa030220.78087723
51Viral myocarditis_Homo sapiens_hsa054160.75864742
52Nitrogen metabolism_Homo sapiens_hsa009100.74655288
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69727665
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68034542
55Butanoate metabolism_Homo sapiens_hsa006500.68016734
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67440698
57Caffeine metabolism_Homo sapiens_hsa002320.65175319
58RNA transport_Homo sapiens_hsa030130.64775901
59Malaria_Homo sapiens_hsa051440.64184083
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63430480
61Base excision repair_Homo sapiens_hsa034100.63408645
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62842341
63Sulfur metabolism_Homo sapiens_hsa009200.61964900
64Folate biosynthesis_Homo sapiens_hsa007900.53305084
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.51172128
66Metabolic pathways_Homo sapiens_hsa011000.49400284
67Epstein-Barr virus infection_Homo sapiens_hsa051690.48633300
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.47437879
69Systemic lupus erythematosus_Homo sapiens_hsa053220.46359807
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46291673
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46185351
72Retinol metabolism_Homo sapiens_hsa008300.45864152
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45639783
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.45279020
75Pyruvate metabolism_Homo sapiens_hsa006200.40989678
76Linoleic acid metabolism_Homo sapiens_hsa005910.39688613
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.39624948
78Collecting duct acid secretion_Homo sapiens_hsa049660.37057319
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36927104
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35255778
81Herpes simplex infection_Homo sapiens_hsa051680.34536601
82Chemical carcinogenesis_Homo sapiens_hsa052040.33834992
83Steroid biosynthesis_Homo sapiens_hsa001000.33497215
84Tryptophan metabolism_Homo sapiens_hsa003800.32014479
85N-Glycan biosynthesis_Homo sapiens_hsa005100.31686072
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31320838
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30037090
88HTLV-I infection_Homo sapiens_hsa051660.29712817
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29346530
90Olfactory transduction_Homo sapiens_hsa047400.28445354
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.26932766
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22458812
93Sulfur relay system_Homo sapiens_hsa041220.21585391
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20868708
95Fatty acid elongation_Homo sapiens_hsa000620.20608164
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18983855
97Glutathione metabolism_Homo sapiens_hsa004800.18696175
98Legionellosis_Homo sapiens_hsa051340.17026406
99Carbon metabolism_Homo sapiens_hsa012000.15735592
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15334904

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