ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	8.18175099
2	regulation of isotype switching to IgG isotypes (GO:0048302)	7.89644386
3	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	7.51473334
4	positive regulation of interleukin-17 production (GO:0032740)	7.13066851
5	regulation of regulatory T cell differentiation (GO:0045589)	7.02440432
6	regulation of immunoglobulin secretion (GO:0051023)	6.80646959
7	positive regulation of isotype switching (GO:0045830)	6.45937452
8	positive regulation of DNA recombination (GO:0045911)	5.91327883
9	negative regulation of B cell apoptotic process (GO:0002903)	5.13169112
10	negative regulation of T-helper cell differentiation (GO:0045623)	5.03737045
11	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	5.03737045
12	positive regulation of activated T cell proliferation (GO:0042104)	4.86167269
13	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.59959993
14	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.59959993
15	regulation of interleukin-17 production (GO:0032660)	4.59853300
16	regulation of activated T cell proliferation (GO:0046006)	4.38391225
17	positive regulation of immunoglobulin production (GO:0002639)	4.31230580
18	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	4.29568139
19	regulation of memory T cell differentiation (GO:0043380)	4.27957143
20	somatic diversification of immune receptors via somatic mutation (GO:0002566)	4.27023321
21	somatic hypermutation of immunoglobulin genes (GO:0016446)	4.27023321
22	proteasome assembly (GO:0043248)	4.24162988
23	ribosomal large subunit biogenesis (GO:0042273)	4.11007450
24	regulation of isotype switching (GO:0045191)	4.07907149
25	negative regulation of alpha-beta T cell differentiation (GO:0046639)	3.95369514
26	positive regulation of immunoglobulin mediated immune response (GO:0002891)	3.74808129
27	positive regulation of B cell mediated immunity (GO:0002714)	3.74808129
28	regulation of chronic inflammatory response (GO:0002676)	3.68949931
29	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.56180474
30	ATP synthesis coupled proton transport (GO:0015986)	3.56180474
31	positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)	3.54034905
32	ribosomal small subunit assembly (GO:0000028)	3.50956938
33	synapsis (GO:0007129)	3.45396803
34	regulation of T-helper cell differentiation (GO:0045622)	3.39696559
35	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.38977676
36	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.36105110
37	regulation of podosome assembly (GO:0071801)	3.33463368
38	DNA deamination (GO:0045006)	3.32547574
39	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	3.20757454
40	positive regulation of JAK-STAT cascade (GO:0046427)	3.18011376
41	regulation of tyrosine phosphorylation of STAT protein (GO:0042509)	3.17127670
42	regulation of immunoglobulin production (GO:0002637)	3.12929669
43	transcription from mitochondrial promoter (GO:0006390)	3.12851991
44	behavioral response to nicotine (GO:0035095)	3.08305063
45	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.04435870
46	negative regulation of alpha-beta T cell activation (GO:0046636)	3.03422308
47	ventricular cardiac muscle cell development (GO:0055015)	3.01041798
48	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.00397008
49	regulation of cellular amino acid metabolic process (GO:0006521)	3.00205719
50	protein complex biogenesis (GO:0070271)	3.00071009
51	positive regulation of dendritic spine development (GO:0060999)	2.98700572
52	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.98608578
53	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.96122037
54	positive regulation of T-helper cell differentiation (GO:0045624)	2.93789252
55	piRNA metabolic process (GO:0034587)	2.90734269
56	DNA damage response, detection of DNA damage (GO:0042769)	2.90472920
57	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.89107972
58	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.89107972
59	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.88849792
60	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.88849792
61	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.88849792
62	negative regulation of T cell differentiation in thymus (GO:0033085)	2.86549319
63	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.86041633
64	chaperone-mediated protein transport (GO:0072321)	2.84975497
65	negative regulation of T cell differentiation (GO:0045581)	2.84288039
66	oxidative phosphorylation (GO:0006119)	2.83876859
67	signal peptide processing (GO:0006465)	2.83255775
68	heart process (GO:0003015)	2.83094421
69	heart contraction (GO:0060047)	2.83094421
70	translational termination (GO:0006415)	2.82642303
71	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.79443370
72	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.79443370
73	isotype switching (GO:0045190)	2.79443370
74	positive regulation of chemokine biosynthetic process (GO:0045080)	2.78720814
75	GTP biosynthetic process (GO:0006183)	2.78093633
76	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.76408586
77	termination of RNA polymerase III transcription (GO:0006386)	2.76408586
78	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	2.75208172
79	UMP metabolic process (GO:0046049)	2.75208172
80	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	2.75208172
81	UMP biosynthetic process (GO:0006222)	2.75208172
82	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.73914615
83	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.73271203
84	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.73271203
85	regulation of B cell apoptotic process (GO:0002902)	2.72654289
86	viral transcription (GO:0019083)	2.70586840
87	translation (GO:0006412)	2.70081645
88	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.69087694
89	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.69083000
90	cotranslational protein targeting to membrane (GO:0006613)	2.68823590
91	regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)	2.68031170
92	mitochondrial respiratory chain complex assembly (GO:0033108)	2.67428544
93	aldehyde catabolic process (GO:0046185)	2.66387063
94	negative regulation of ligase activity (GO:0051352)	2.66086533
95	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.66086533
96	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.65327812
97	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.63475240
98	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.63474483
99	NADH dehydrogenase complex assembly (GO:0010257)	2.63474483
100	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.63474483

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.73838548
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.52028657
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.97739724
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.70432056
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.67269380
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.59770752
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.28793022
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.13591686
9	TAF15_26573619_Chip-Seq_HEK293_Human	3.02921414
10	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.89515938
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.70390817
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.70258583
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.62311790
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.59422688
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.49882240
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.47044713
17	EWS_26573619_Chip-Seq_HEK293_Human	2.45179702
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.34455777
19	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.29021064
20	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.27994403
21	FOXP3_21729870_ChIP-Seq_TREG_Human	2.18394596
22	ZNF274_21170338_ChIP-Seq_K562_Hela	2.15806940
23	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.03402297
24	VDR_22108803_ChIP-Seq_LS180_Human	1.98029011
25	FUS_26573619_Chip-Seq_HEK293_Human	1.97088143
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.92407536
27	E2F7_22180533_ChIP-Seq_HELA_Human	1.78695294
28	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.76877050
29	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.75399571
30	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.66781838
31	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.65512703
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.61431749
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57870809
34	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.54570692
35	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.53406619
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.48503889
37	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.46578847
38	TTF2_22483619_ChIP-Seq_HELA_Human	1.45329275
39	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.40793484
40	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.40212199
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39746521
42	GATA3_26560356_Chip-Seq_TH2_Human	1.35778995
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.33922355
44	ER_23166858_ChIP-Seq_MCF-7_Human	1.33631972
45	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.33284153
46	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.33262362
47	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.32282686
48	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30946065
49	DCP1A_22483619_ChIP-Seq_HELA_Human	1.28672235
50	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.28323434
51	XRN2_22483619_ChIP-Seq_HELA_Human	1.22087067
52	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.21908388
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21483877
54	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.20643316
55	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.20569813
56	P300_19829295_ChIP-Seq_ESCs_Human	1.20482811
57	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19615182
58	IRF1_19129219_ChIP-ChIP_H3396_Human	1.19223460
59	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.18790968
60	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.15858588
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14538682
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14538682
63	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14377899
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.10660953
65	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.09394184
66	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.09334864
67	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.07668262
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.06458272
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04055819
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04055819
71	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.02881349
72	ERA_21632823_ChIP-Seq_H3396_Human	1.01242971
73	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.99086760
74	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97097153
75	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96528044
76	NCOR_22424771_ChIP-Seq_293T_Human	0.95900048
77	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.95467331
78	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.95402700
79	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.93864394
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.93300437
81	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.90990391
82	BCAT_22108803_ChIP-Seq_LS180_Human	0.90306189
83	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.90252852
84	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.90234062
85	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88812159
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.88198319
87	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.87646663
88	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.85641415
89	MYC_19829295_ChIP-Seq_ESCs_Human	0.85581710
90	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.85553675
91	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.85513287
92	GABP_19822575_ChIP-Seq_HepG2_Human	0.85441129
93	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.84815294
94	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.84576399
95	MYB_26560356_Chip-Seq_TH2_Human	0.83771856
96	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.83148448
97	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.82906272
98	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.82732661
99	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.82514809
100	PHF8_20622853_ChIP-Seq_HELA_Human	0.81866650

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	5.33704197
2	MP0003300_gastrointestinal_ulcer	3.58103217
3	MP0001873_stomach_inflammation	3.29826561
4	MP0001853_heart_inflammation	3.19181592
5	MP0003806_abnormal_nucleotide_metabolis	3.13972055
6	MP0008058_abnormal_DNA_repair	3.08378644
7	MP0004885_abnormal_endolymph	2.99934889
8	MP0000465_gastrointestinal_hemorrhage	2.87702482
9	MP0008872_abnormal_physiological_respon	2.69701950
10	MP0006292_abnormal_olfactory_placode	2.54270680
11	MP0008875_abnormal_xenobiotic_pharmacok	2.39643807
12	MP0008260_abnormal_autophagy	2.36979503
13	MP0005671_abnormal_response_to	2.27735483
14	MP0002234_abnormal_pharynx_morphology	2.17399516
15	MP0005084_abnormal_gallbladder_morpholo	2.13233061
16	MP0000372_irregular_coat_pigmentation	1.98657495
17	MP0004147_increased_porphyrin_level	1.96482790
18	MP0006072_abnormal_retinal_apoptosis	1.92112136
19	MP0010094_abnormal_chromosome_stability	1.89894476
20	MP0009333_abnormal_splenocyte_physiolog	1.85260859
21	MP0003724_increased_susceptibility_to	1.82645082
22	MP0002277_abnormal_respiratory_mucosa	1.81857535
23	MP0002148_abnormal_hypersensitivity_rea	1.76869456
24	MP0001293_anophthalmia	1.66009343
25	MP0003880_abnormal_central_pattern	1.64476444
26	MP0000604_amyloidosis	1.63466667
27	MP0001485_abnormal_pinna_reflex	1.62089470
28	MP0002166_altered_tumor_susceptibility	1.53249489
29	MP0002006_tumorigenesis	1.47056618
30	MP0002405_respiratory_system_inflammati	1.42156334
31	MP0001790_abnormal_immune_system	1.41637247
32	MP0005387_immune_system_phenotype	1.41637247
33	MP0003763_abnormal_thymus_physiology	1.41129224
34	MP0005000_abnormal_immune_tolerance	1.40678128
35	MP0002796_impaired_skin_barrier	1.40027264
36	MP0001800_abnormal_humoral_immune	1.39698967
37	MP0003186_abnormal_redox_activity	1.36898784
38	MP0003786_premature_aging	1.31917314
39	MP0009785_altered_susceptibility_to	1.31207900
40	MP0002210_abnormal_sex_determination	1.24104858
41	MP0006036_abnormal_mitochondrial_physio	1.21558978
42	MP0004142_abnormal_muscle_tone	1.20327921
43	MP0004145_abnormal_muscle_electrophysio	1.13507384
44	MP0002938_white_spotting	1.12634242
45	MP0002736_abnormal_nociception_after	1.11953249
46	MP0003866_abnormal_defecation	1.11722728
47	MP0008789_abnormal_olfactory_epithelium	1.10111213
48	MP0001968_abnormal_touch/_nociception	1.08708694
49	MP0004742_abnormal_vestibular_system	1.06904591
50	MP0004215_abnormal_myocardial_fiber	1.06506722
51	MP0001440_abnormal_grooming_behavior	1.04613600
52	MP0000049_abnormal_middle_ear	1.04282442
53	MP0004957_abnormal_blastocyst_morpholog	1.02587273
54	MP0004782_abnormal_surfactant_physiolog	1.00871302
55	MP0002282_abnormal_trachea_morphology	0.99740359
56	MP0001984_abnormal_olfaction	0.99296316
57	MP0001529_abnormal_vocalization	0.96894577
58	MP0000490_abnormal_crypts_of	0.96758237
59	MP0001929_abnormal_gametogenesis	0.92435796
60	MP0002723_abnormal_immune_serum	0.89809961
61	MP0002928_abnormal_bile_duct	0.88566348
62	MP0009745_abnormal_behavioral_response	0.88342742
63	MP0001819_abnormal_immune_cell	0.88267491
64	MP0001845_abnormal_inflammatory_respons	0.88234160
65	MP0002420_abnormal_adaptive_immunity	0.88136504
66	MP0002398_abnormal_bone_marrow	0.86011612
67	MP0002452_abnormal_antigen_presenting	0.85556670
68	MP0005360_urolithiasis	0.85200308
69	MP0009697_abnormal_copulation	0.84222110
70	MP0005410_abnormal_fertilization	0.82297163
71	MP0003693_abnormal_embryo_hatching	0.80962999
72	MP0005551_abnormal_eye_electrophysiolog	0.80898559
73	MP0001986_abnormal_taste_sensitivity	0.80648414
74	MP0001119_abnormal_female_reproductive	0.80635829
75	MP0002751_abnormal_autonomic_nervous	0.80499006
76	MP0004185_abnormal_adipocyte_glucose	0.79386246
77	MP0009764_decreased_sensitivity_to	0.78771769
78	MP0002653_abnormal_ependyma_morphology	0.78095106
79	MP0008873_increased_physiological_sensi	0.76378194
80	MP0003567_abnormal_fetal_cardiomyocyte	0.75214740
81	MP0010155_abnormal_intestine_physiology	0.74498688
82	MP0001145_abnormal_male_reproductive	0.74386003
83	MP0004134_abnormal_chest_morphology	0.73851746
84	MP0000653_abnormal_sex_gland	0.72166905
85	MP0005253_abnormal_eye_physiology	0.72091795
86	MP0000631_abnormal_neuroendocrine_gland	0.70730617
87	MP0005025_abnormal_response_to	0.69025255
88	MP0001663_abnormal_digestive_system	0.67124438
89	MP0002429_abnormal_blood_cell	0.67002548
90	MP0000689_abnormal_spleen_morphology	0.66809181
91	MP0001502_abnormal_circadian_rhythm	0.66717587
92	MP0003315_abnormal_perineum_morphology	0.66610046
93	MP0006035_abnormal_mitochondrial_morpho	0.65467772
94	MP0001348_abnormal_lacrimal_gland	0.65402299
95	MP0006082_CNS_inflammation	0.64091560
96	MP0002735_abnormal_chemical_nociception	0.63455796
97	MP0005670_abnormal_white_adipose	0.63371387
98	MP0002160_abnormal_reproductive_system	0.62824471
99	MP0000716_abnormal_immune_system	0.62400292
100	MP0008877_abnormal_DNA_methylation	0.62255923

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Microvesicular hepatic steatosis (HP:0001414)	4.40015165
2	Ependymoma (HP:0002888)	4.39473624
3	Abnormality of alanine metabolism (HP:0010916)	4.17616150
4	Hyperalaninemia (HP:0003348)	4.17616150
5	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.17616150
6	Intestinal atresia (HP:0011100)	3.86230683
7	Volvulus (HP:0002580)	3.78372552
8	Hepatocellular necrosis (HP:0001404)	3.52777273
9	Increased hepatocellular lipid droplets (HP:0006565)	3.52525638
10	Elevated erythrocyte sedimentation rate (HP:0003565)	3.47012888
11	Mitochondrial inheritance (HP:0001427)	3.35285208
12	Increased CSF lactate (HP:0002490)	3.34743480
13	Lipid accumulation in hepatocytes (HP:0006561)	3.31902734
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.20906598
15	Molar tooth sign on MRI (HP:0002419)	3.16173332
16	Abnormality of midbrain morphology (HP:0002418)	3.16173332
17	Hepatic necrosis (HP:0002605)	3.13911227
18	Increased intramyocellular lipid droplets (HP:0012240)	3.10520219
19	Agnosia (HP:0010524)	3.02359530
20	Acute necrotizing encephalopathy (HP:0006965)	3.01142809
21	Large for gestational age (HP:0001520)	2.98987613
22	Renal Fanconi syndrome (HP:0001994)	2.96355988
23	Nephronophthisis (HP:0000090)	2.83734971
24	Abnormality of the astrocytes (HP:0100707)	2.75695680
25	Astrocytoma (HP:0009592)	2.75695680
26	Increased serum lactate (HP:0002151)	2.74587410
27	Exertional dyspnea (HP:0002875)	2.73005158
28	Cleft eyelid (HP:0000625)	2.72288442
29	Increased muscle lipid content (HP:0009058)	2.65908002
30	Glioma (HP:0009733)	2.65447279
31	Optic nerve coloboma (HP:0000588)	2.64486589
32	Congenital, generalized hypertrichosis (HP:0004540)	2.60431201
33	Colon cancer (HP:0003003)	2.55924901
34	Respiratory difficulties (HP:0002880)	2.54300113
35	Acute encephalopathy (HP:0006846)	2.52280133
36	Progressive macrocephaly (HP:0004481)	2.47628789
37	3-Methylglutaconic aciduria (HP:0003535)	2.45946985
38	Abnormality of the renal medulla (HP:0100957)	2.38824303
39	Lactic acidosis (HP:0003128)	2.35043838
40	Stomatitis (HP:0010280)	2.32364544
41	Abnormal biliary tract physiology (HP:0012439)	2.30902853
42	Bile duct proliferation (HP:0001408)	2.30902853
43	Chronic sinusitis (HP:0011109)	2.27612297
44	Amaurosis fugax (HP:0100576)	2.25258625
45	Abnormality of serum amino acid levels (HP:0003112)	2.24206618
46	Congenital stationary night blindness (HP:0007642)	2.22406535
47	Abnormality of the renal cortex (HP:0011035)	2.22248470
48	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.19215071
49	Renal cortical cysts (HP:0000803)	2.18154845
50	Leukodystrophy (HP:0002415)	2.18149185
51	Gastrointestinal atresia (HP:0002589)	2.18135842
52	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.14189838
53	Thrombocytosis (HP:0001894)	2.12651820
54	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.12222511
55	Bony spicule pigmentary retinopathy (HP:0007737)	2.11684528
56	Poor speech (HP:0002465)	2.07251466
57	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.05366618
58	Retinal dysplasia (HP:0007973)	2.05072035
59	Delayed CNS myelination (HP:0002188)	2.04510186
60	Abnormal number of incisors (HP:0011064)	2.04204672
61	Abnormality of cochlea (HP:0000375)	2.03834734
62	Abnormality of the ileum (HP:0001549)	2.03647035
63	Chronic hepatic failure (HP:0100626)	1.99074779
64	Abnormality of placental membranes (HP:0011409)	1.98795055
65	Amniotic constriction ring (HP:0009775)	1.98795055
66	Pancreatic islet-cell hyperplasia (HP:0004510)	1.96276137
67	Broad-based gait (HP:0002136)	1.94491293
68	Conjugated hyperbilirubinemia (HP:0002908)	1.94428805
69	IgG deficiency (HP:0004315)	1.93881954
70	CNS demyelination (HP:0007305)	1.91295547
71	Dyskinesia (HP:0100660)	1.87760211
72	Abnormality of the left ventricular outflow tract (HP:0011103)	1.86794422
73	Subaortic stenosis (HP:0001682)	1.86794422
74	Hypoproteinemia (HP:0003075)	1.86418133
75	Abnormal rod and cone electroretinograms (HP:0008323)	1.85963972
76	Aplastic anemia (HP:0001915)	1.85585202
77	Medulloblastoma (HP:0002885)	1.85430254
78	Morphological abnormality of the inner ear (HP:0011390)	1.84593398
79	Macrocytic anemia (HP:0001972)	1.84055548
80	Oligodactyly (hands) (HP:0001180)	1.81635695
81	Respiratory failure (HP:0002878)	1.81083761
82	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.81067002
83	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.81067002
84	Severe combined immunodeficiency (HP:0004430)	1.80068483
85	Embryonal renal neoplasm (HP:0011794)	1.79224381
86	Parakeratosis (HP:0001036)	1.77608655
87	Intellectual disability, profound (HP:0002187)	1.77248899
88	Rhabdomyosarcoma (HP:0002859)	1.74559084
89	Nephroblastoma (Wilms tumor) (HP:0002667)	1.73400904
90	Constricted visual fields (HP:0001133)	1.72854061
91	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.71773967
92	Triphalangeal thumb (HP:0001199)	1.70786534
93	Hyperventilation (HP:0002883)	1.70754041
94	Hypomagnesemia (HP:0002917)	1.70151788
95	Short tibia (HP:0005736)	1.69204770
96	Amelogenesis imperfecta (HP:0000705)	1.68998180
97	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.67897566
98	Horseshoe kidney (HP:0000085)	1.66802323
99	Abnormal spermatogenesis (HP:0008669)	1.66588620
100	Exercise intolerance (HP:0003546)	1.64928732

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CAMKK2	5.16907415
2	PBK	4.19506659
3	BRSK2	3.95151991
4	BUB1	2.98283259
5	WEE1	2.91290237
6	ACVR1B	2.54093395
7	VRK2	2.48759584
8	NEK1	2.37519698
9	PDK2	2.26791458
10	CAMK1D	2.18851184
11	RPS6KA4	1.95343461
12	CDK19	1.84148475
13	CCNB1	1.82230398
14	TSSK6	1.71918613
15	WNK3	1.65763198
16	CAMKK1	1.64396201
17	OXSR1	1.64224814
18	BRD4	1.63467797
19	BRSK1	1.63346043
20	TRIM28	1.55359057
21	NUAK1	1.41425066
22	EIF2AK3	1.40196026
23	CAMK1G	1.36635069
24	ADRBK2	1.35270661
25	EIF2AK1	1.33479181
26	MST4	1.31833539
27	NME1	1.29957000
28	ZAK	1.27709328
29	TLK1	1.23843449
30	NME2	1.21048891
31	MAP3K14	1.18138552
32	NEK2	1.17314093
33	PAK4	1.16593125
34	SRPK1	1.15988781
35	TEC	1.13741533
36	TXK	1.12767993
37	PLK4	1.11802927
38	VRK1	1.10136152
39	PAK6	1.06231862
40	ATR	1.04976195
41	SGK2	1.03631840
42	PLK3	1.03487613
43	KDR	1.00149496
44	BMPR1B	0.97101699
45	INSRR	0.96909094
46	FRK	0.92268800
47	MYLK	0.92178770
48	WNK1	0.90256908
49	GRK1	0.89568368
50	IKBKB	0.78292980
51	STK38L	0.77748139
52	STK39	0.73475271
53	PASK	0.71964386
54	PLK1	0.71959375
55	DYRK2	0.71263935
56	DYRK3	0.69880559
57	SGK223	0.67560957
58	SGK494	0.67560957
59	STK4	0.66642975
60	ITK	0.66423291
61	DAPK1	0.64707231
62	SCYL2	0.63145715
63	WNK4	0.61827465
64	SYK	0.59263825
65	CAMK4	0.58825582
66	STK3	0.57817217
67	TGFBR1	0.57705114
68	EGFR	0.54212808
69	CSNK2A2	0.53586818
70	EIF2AK2	0.50906956
71	STK24	0.49989034
72	CSNK2A1	0.49610395
73	KSR1	0.48627525
74	FGFR1	0.47627359
75	PNCK	0.47294066
76	YES1	0.46449008
77	AURKB	0.46291103
78	BTK	0.45296436
79	MAP3K12	0.43134888
80	LYN	0.43098765
81	RPS6KA6	0.42974305
82	PRKCG	0.42787670
83	CSNK1G1	0.39667482
84	CSNK1G3	0.39306080
85	CDK9	0.38430247
86	RPS6KA5	0.38110764
87	GRK5	0.38005078
88	PLK2	0.37874074
89	ILK	0.34347951
90	CAMK2D	0.33944231
91	CSK	0.33814922
92	OBSCN	0.32928188
93	NEK9	0.31601412
94	CSNK1E	0.30687110
95	MAPK13	0.29927374
96	ALK	0.29103431
97	CAMK1	0.28471297
98	RPS6KC1	0.28129474
99	RPS6KL1	0.28129474
100	ERBB2	0.28071253

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.68731184
2	Allograft rejection_Homo sapiens_hsa05330	4.57883151
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	4.13530049
4	Proteasome_Homo sapiens_hsa03050	3.93949180
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.73282229
6	Graft-versus-host disease_Homo sapiens_hsa05332	3.34578518
7	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	3.04620782
8	Type I diabetes mellitus_Homo sapiens_hsa04940	3.04014357
9	Mismatch repair_Homo sapiens_hsa03430	2.80996321
10	Ribosome_Homo sapiens_hsa03010	2.68602373
11	RNA polymerase_Homo sapiens_hsa03020	2.33486319
12	Protein export_Homo sapiens_hsa03060	2.32205607
13	Oxidative phosphorylation_Homo sapiens_hsa00190	2.31366574
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.11254886
15	Parkinsons disease_Homo sapiens_hsa05012	2.04357047
16	DNA replication_Homo sapiens_hsa03030	1.89721691
17	Basal transcription factors_Homo sapiens_hsa03022	1.68010822
18	Regulation of autophagy_Homo sapiens_hsa04140	1.61602999
19	Non-homologous end-joining_Homo sapiens_hsa03450	1.60100903
20	Homologous recombination_Homo sapiens_hsa03440	1.57853273
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.53454488
22	RNA transport_Homo sapiens_hsa03013	1.44661681
23	Huntingtons disease_Homo sapiens_hsa05016	1.40221781
24	Rheumatoid arthritis_Homo sapiens_hsa05323	1.39938819
25	Base excision repair_Homo sapiens_hsa03410	1.39241958
26	One carbon pool by folate_Homo sapiens_hsa00670	1.23904420
27	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.21953345
28	Spliceosome_Homo sapiens_hsa03040	1.16285080
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.15896352
30	Antigen processing and presentation_Homo sapiens_hsa04612	1.15865272
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.14206617
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.13774343
33	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.10895066
34	Alzheimers disease_Homo sapiens_hsa05010	1.10620571
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.10255686
36	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.05074321
37	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.00386469
38	RNA degradation_Homo sapiens_hsa03018	0.97428255
39	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.90025466
40	Primary immunodeficiency_Homo sapiens_hsa05340	0.86926148
41	Viral myocarditis_Homo sapiens_hsa05416	0.84896851
42	Propanoate metabolism_Homo sapiens_hsa00640	0.83882265
43	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.83320538
44	Leishmaniasis_Homo sapiens_hsa05140	0.75230146
45	Cardiac muscle contraction_Homo sapiens_hsa04260	0.74589454
46	Measles_Homo sapiens_hsa05162	0.66796207
47	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.64851699
48	Purine metabolism_Homo sapiens_hsa00230	0.63721481
49	Peroxisome_Homo sapiens_hsa04146	0.63179543
50	Fatty acid elongation_Homo sapiens_hsa00062	0.63082441
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.62238443
52	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.60800981
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.55057219
54	Pyruvate metabolism_Homo sapiens_hsa00620	0.54842238
55	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.53943779
56	Phototransduction_Homo sapiens_hsa04744	0.52354632
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.49645446
58	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.45859877
59	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.42623327
60	Caffeine metabolism_Homo sapiens_hsa00232	0.42019695
61	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.39769505
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.38996027
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.37932459
64	Cell cycle_Homo sapiens_hsa04110	0.37789136
65	Glutathione metabolism_Homo sapiens_hsa00480	0.37159735
66	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.34956230
67	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33911022
68	Taste transduction_Homo sapiens_hsa04742	0.33657192
69	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.33519236
70	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.31224442
71	Sulfur relay system_Homo sapiens_hsa04122	0.30345156
72	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.29787301
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.29718707
74	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.29050488
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.28023867
76	Circadian rhythm_Homo sapiens_hsa04710	0.27818371
77	Herpes simplex infection_Homo sapiens_hsa05168	0.26919646
78	Olfactory transduction_Homo sapiens_hsa04740	0.26383737
79	Oocyte meiosis_Homo sapiens_hsa04114	0.25980147
80	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.25072263
81	Legionellosis_Homo sapiens_hsa05134	0.24056359
82	HTLV-I infection_Homo sapiens_hsa05166	0.22433228
83	Collecting duct acid secretion_Homo sapiens_hsa04966	0.21957997
84	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.21351010
85	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.20599784
86	Metabolic pathways_Homo sapiens_hsa01100	0.18951284
87	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.17952032
88	Butanoate metabolism_Homo sapiens_hsa00650	0.17259166
89	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.16771907
90	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.16482901
91	Salivary secretion_Homo sapiens_hsa04970	0.15191171
92	Retinol metabolism_Homo sapiens_hsa00830	0.14826829
93	Toxoplasmosis_Homo sapiens_hsa05145	0.12003650
94	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.11593894
95	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.10872190
96	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.10843402
97	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.09773790
98	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.09293498
99	Ether lipid metabolism_Homo sapiens_hsa00565	0.07007700
100	African trypanosomiasis_Homo sapiens_hsa05143	0.04577440

RANP8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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