RAP1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.42692598
2axon ensheathment (GO:0008366)7.04968897
3ensheathment of neurons (GO:0007272)7.04968897
4myelination (GO:0042552)6.96594054
5cholesterol biosynthetic process (GO:0006695)5.75698987
6positive regulation of gamma-delta T cell activation (GO:0046645)5.64332171
7myelin maintenance (GO:0043217)5.59067203
8creatine metabolic process (GO:0006600)5.33896354
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.25834861
10negative regulation of cell killing (GO:0031342)5.25834861
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.05180919
12sterol biosynthetic process (GO:0016126)5.01922553
13long-chain fatty acid biosynthetic process (GO:0042759)4.88219352
14amyloid precursor protein metabolic process (GO:0042982)4.87275703
15modulation by symbiont of host defense response (GO:0052031)4.76740820
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.76740820
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.76740820
18positive regulation by organism of defense response of other organism involved in symbiotic interact4.76740820
19modulation by symbiont of host immune response (GO:0052553)4.76740820
20positive regulation by symbiont of host defense response (GO:0052509)4.76740820
21regulation of B cell receptor signaling pathway (GO:0050855)4.63650304
22long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.60692947
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.51845590
24antigen processing and presentation of endogenous antigen (GO:0019883)4.48238831
25response to methylmercury (GO:0051597)4.43393373
26isoprenoid biosynthetic process (GO:0008299)4.27376104
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.21479388
28response to peptidoglycan (GO:0032494)4.17255436
29response to lipoprotein particle (GO:0055094)4.16919683
30virion attachment to host cell (GO:0019062)4.13427287
31adhesion of symbiont to host cell (GO:0044650)4.13427287
32macrophage activation involved in immune response (GO:0002281)4.09026033
33fatty-acyl-CoA biosynthetic process (GO:0046949)4.07992051
34negative regulation of interleukin-12 production (GO:0032695)4.04731905
35leukocyte migration involved in inflammatory response (GO:0002523)4.04458307
36detection of other organism (GO:0098543)4.04222551
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.00259070
38oligodendrocyte differentiation (GO:0048709)4.00015485
39regulation of gamma-delta T cell activation (GO:0046643)3.98922317
40glycerophospholipid catabolic process (GO:0046475)3.97187520
41positive regulation of oligodendrocyte differentiation (GO:0048714)3.94885096
42regulation of collateral sprouting (GO:0048670)3.93990093
43long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.93446691
44amyloid precursor protein catabolic process (GO:0042987)3.91999601
45protein localization to endosome (GO:0036010)3.88611965
46cellular extravasation (GO:0045123)3.85941858
47astrocyte development (GO:0014002)3.83221149
48detection of bacterium (GO:0016045)3.82733847
49asymmetric protein localization (GO:0008105)3.81397703
50import into cell (GO:0098657)3.77434146
51immunoglobulin mediated immune response (GO:0016064)3.74241761
52detection of molecule of bacterial origin (GO:0032490)3.65642068
53regulation of lipoprotein metabolic process (GO:0050746)3.63069683
54positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.62506429
55magnesium ion transport (GO:0015693)3.62197703
56negative regulation of T cell mediated immunity (GO:0002710)3.62037960
57photoreceptor cell differentiation (GO:0046530)3.60589573
58eye photoreceptor cell differentiation (GO:0001754)3.60589573
59fatty-acyl-CoA metabolic process (GO:0035337)3.60161821
60B cell receptor signaling pathway (GO:0050853)3.58915737
61regulation of gamma-delta T cell differentiation (GO:0045586)3.58457058
62nucleotide transmembrane transport (GO:1901679)3.58228845
63detection of external biotic stimulus (GO:0098581)3.58203602
64negative regulation of erythrocyte differentiation (GO:0045647)3.49907771
65thioester biosynthetic process (GO:0035384)3.49274392
66acyl-CoA biosynthetic process (GO:0071616)3.49274392
67substantia nigra development (GO:0021762)3.48441457
68establishment of mitochondrion localization (GO:0051654)3.48092387
69negative regulation of protein localization to cell surface (GO:2000009)3.46438960
70response to host immune response (GO:0052572)3.46322570
71response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.46322570
72negative regulation of lymphocyte mediated immunity (GO:0002707)3.44495057
73regulation of interferon-beta biosynthetic process (GO:0045357)3.43937690
74protein palmitoylation (GO:0018345)3.43812222
75response to redox state (GO:0051775)3.42916128
76glycosylceramide metabolic process (GO:0006677)3.39012333
77very long-chain fatty acid metabolic process (GO:0000038)3.37249921
78positive regulation of B cell differentiation (GO:0045579)3.36962627
79positive regulation of cellular amine metabolic process (GO:0033240)3.35429370
80peptidyl-tyrosine autophosphorylation (GO:0038083)3.29512940
81interferon-gamma-mediated signaling pathway (GO:0060333)3.29364300
82GPI anchor biosynthetic process (GO:0006506)3.29009245
83signal peptide processing (GO:0006465)3.27620731
84positive regulation of mast cell activation (GO:0033005)3.26996750
85negative thymic T cell selection (GO:0045060)3.26354773
86membrane raft organization (GO:0031579)3.26176535
87negative T cell selection (GO:0043383)3.24740358
88adhesion of symbiont to host (GO:0044406)3.24319340
89response to host (GO:0075136)3.23516179
90response to host defenses (GO:0052200)3.23516179
91response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.23516179
92positive thymic T cell selection (GO:0045059)3.21761962
93neutrophil activation (GO:0042119)3.21603194
94regulation of T cell tolerance induction (GO:0002664)3.19680642
95membrane protein ectodomain proteolysis (GO:0006509)3.19205230
96myeloid cell activation involved in immune response (GO:0002275)3.19040711
97response to interleukin-15 (GO:0070672)3.17137625
98apical protein localization (GO:0045176)3.16743351
99microglial cell activation (GO:0001774)3.14018514
100germinal center formation (GO:0002467)3.13077710
101negative regulation of execution phase of apoptosis (GO:1900118)3.12675637
102type I interferon signaling pathway (GO:0060337)3.11779640
103cellular response to type I interferon (GO:0071357)3.11779640
104GPI anchor metabolic process (GO:0006505)3.11736579
105regulation of tolerance induction (GO:0002643)3.11295492
106granulocyte activation (GO:0036230)3.10662094
107lipopolysaccharide-mediated signaling pathway (GO:0031663)3.09593699
108regulation of mast cell degranulation (GO:0043304)3.09293868
109negative regulation of leukocyte mediated immunity (GO:0002704)3.08837945
110response to type I interferon (GO:0034340)3.08114450
111negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.07539263
112axon development (GO:0061564)3.07449646
113tissue regeneration (GO:0042246)3.06883703
114detection of biotic stimulus (GO:0009595)3.06770925
115regulation of alpha-beta T cell proliferation (GO:0046640)3.06103571
116tolerance induction (GO:0002507)3.04976158
117T cell migration (GO:0072678)3.04263362
118regulation of T-helper 2 cell differentiation (GO:0045628)3.02459314
119B cell mediated immunity (GO:0019724)3.02417471
120heme transport (GO:0015886)3.01261778
121interleukin-6-mediated signaling pathway (GO:0070102)3.00750663
122regulation of B cell differentiation (GO:0045577)2.97680685
123antigen processing and presentation via MHC class Ib (GO:0002475)2.97570768
124preassembly of GPI anchor in ER membrane (GO:0016254)2.96682749
125macrophage activation (GO:0042116)2.96077700
126regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.92971280
127positive regulation of glial cell differentiation (GO:0045687)2.92866529
128myelination in peripheral nervous system (GO:0022011)2.92773360
129peripheral nervous system axon ensheathment (GO:0032292)2.92773360
130T cell selection (GO:0045058)2.92661157
131NIK/NF-kappaB signaling (GO:0038061)2.92640518
132localization within membrane (GO:0051668)2.92436544
133response to muramyl dipeptide (GO:0032495)2.92185312
134negative regulation of glucose import (GO:0046325)2.89809732
135regulation of interleukin-2 biosynthetic process (GO:0045076)2.89765269
136myeloid dendritic cell differentiation (GO:0043011)2.88820061
137response to lead ion (GO:0010288)2.88267434
138membrane tubulation (GO:0097320)2.87940673
139cellular response to interleukin-15 (GO:0071350)2.86252070
140negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.85694040
141positive regulation of gliogenesis (GO:0014015)2.85401882
142positive T cell selection (GO:0043368)2.85014606
143positive regulation of cellular amide metabolic process (GO:0034250)2.84351687
144regulation of mast cell activation involved in immune response (GO:0033006)2.81691582
145respiratory burst (GO:0045730)2.81309476
146neutrophil activation involved in immune response (GO:0002283)2.80244952
147positive regulation of actin filament depolymerization (GO:0030836)2.79670193
148activated T cell proliferation (GO:0050798)2.79551532
149peptidyl-cysteine modification (GO:0018198)2.79343720
150positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.79183646
151regulation of regulatory T cell differentiation (GO:0045589)2.78335928
152defense response to protozoan (GO:0042832)2.78255221
153positive regulation of type 2 immune response (GO:0002830)2.78243273
154regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.78200358
155regulation of natural killer cell mediated immunity (GO:0002715)2.78200358
156L-phenylalanine catabolic process (GO:0006559)2.77707209
157erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.77707209
158regulation of mast cell activation (GO:0033003)2.77602806
159myeloid dendritic cell activation (GO:0001773)2.77543742
160cholesterol metabolic process (GO:0008203)2.75740427
161leukocyte aggregation (GO:0070486)2.74879278
162regulation of dendritic cell antigen processing and presentation (GO:0002604)2.74633135
163regulation of leukocyte degranulation (GO:0043300)2.72504011
164positive regulation of B cell mediated immunity (GO:0002714)2.71920245
165positive regulation of immunoglobulin mediated immune response (GO:0002891)2.71920245
166positive regulation of interleukin-17 production (GO:0032740)2.70718971
167thymic T cell selection (GO:0045061)2.70609974
168T-helper 1 type immune response (GO:0042088)2.69316980
169negative regulation of cytokine production involved in immune response (GO:0002719)2.68964073
170regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.68892106
171positive regulation of tolerance induction (GO:0002645)2.67006394
172* negative regulation of neurotransmitter secretion (GO:0046929)2.66779865
173regulation of myeloid leukocyte mediated immunity (GO:0002886)2.66513378
174positive regulation of alpha-beta T cell proliferation (GO:0046641)2.65717551
175regulation of necroptotic process (GO:0060544)2.64511735
176negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.63254268
177alcohol biosynthetic process (GO:0046165)2.60996570
178cortical actin cytoskeleton organization (GO:0030866)2.59556235
179positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.57959855
180negative regulation of interleukin-10 production (GO:0032693)2.55870003
181Golgi to endosome transport (GO:0006895)2.52422063
182negative regulation of acute inflammatory response (GO:0002674)2.52115471
183organ growth (GO:0035265)2.51596745
184glial cell development (GO:0021782)2.50886420
185negative regulation of JUN kinase activity (GO:0043508)2.49116774
186nucleotide transport (GO:0006862)2.48846362
187positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.48410467
188L-amino acid import (GO:0043092)2.48300465
189histone H2B ubiquitination (GO:0033523)2.48109957
190Leydig cell differentiation (GO:0033327)2.47862875
191sterol metabolic process (GO:0016125)2.47216359
192* negative regulation of neurotransmitter transport (GO:0051589)2.46510720
193cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.46291531
194ear development (GO:0043583)2.45517880
195ER overload response (GO:0006983)2.44084689
196axon ensheathment in central nervous system (GO:0032291)10.5020090
197central nervous system myelination (GO:0022010)10.5020090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.82234265
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.11874533
3* SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.96038144
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.38855112
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.03235632
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.83618354
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.77439982
8SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.75068296
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73583750
10GATA1_22025678_ChIP-Seq_K562_Human2.62173234
11RUNX_20019798_ChIP-Seq_JUKART_Human2.60511196
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.59063785
13* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.48546236
14* IRF8_27001747_Chip-Seq_BMDM_Mouse2.36908847
15* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22479831
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.16673756
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.16173382
18* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13937946
19MYC_22102868_ChIP-Seq_BL_Human2.12790736
20PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.11726360
21* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01732488
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.98754138
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.97244873
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.96237939
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92085713
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91641950
27NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.89630314
28* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88777408
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87962918
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.85812855
31* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85675360
32UTX_26944678_Chip-Seq_JUKART_Human1.69378889
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.68527528
34TCF7_22412390_ChIP-Seq_EML_Mouse1.67636634
35TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.65981324
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.62872396
37GATA1_19941826_ChIP-Seq_K562_Human1.61623802
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60710722
39* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.56125161
40TAF15_26573619_Chip-Seq_HEK293_Human1.53767269
41GATA2_22383799_ChIP-Seq_G1ME_Mouse1.52240530
42* MYB_26560356_Chip-Seq_TH2_Human1.51561014
43* GATA1_19941827_ChIP-Seq_MEL_Mouse1.50298182
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49996972
45* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49540141
46* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.48181044
47VDR_24763502_ChIP-Seq_THP-1_Human1.47677734
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44558520
49FOXA1_25552417_ChIP-Seq_VCAP_Human1.44077673
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42870727
51* MAF_26560356_Chip-Seq_TH2_Human1.42402593
52* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41919009
53GATA3_27048872_Chip-Seq_THYMUS_Human1.41364138
54FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.41074424
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40667066
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38994418
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38879666
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36490357
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35908777
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35908777
61* ER_23166858_ChIP-Seq_MCF-7_Human1.34567710
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33571386
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33563591
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32941763
65KDM2B_26808549_Chip-Seq_DND41_Human1.32765040
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31961193
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31340596
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31165681
69SPI1_23547873_ChIP-Seq_NB4_Human1.30843705
70* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29994009
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29581024
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29036653
73VDR_24787735_ChIP-Seq_THP-1_Human1.26914444
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26808724
75* SCL_19346495_ChIP-Seq_HPC-7_Human1.26670648
76LXR_22158963_ChIP-Seq_LIVER_Mouse1.24976984
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.22150511
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21931974
79* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19481662
80* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17334087
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15253450
82PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14572805
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14449297
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13594431
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13542267
86SOX2_20726797_ChIP-Seq_SW620_Human1.12886317
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12700354
88IRF1_19129219_ChIP-ChIP_H3396_Human1.12144734
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11148300
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09334904
91EOMES_21245162_ChIP-Seq_HESCs_Human1.07333016
92* GATA3_26560356_Chip-Seq_TH2_Human1.07151402
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07112496
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06669704
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06383173
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06128848
97RUNX1_22412390_ChIP-Seq_EML_Mouse1.05842369
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.04619121
99EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03444338
100ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03315070
101TRIM28_21343339_ChIP-Seq_HEK293_Human1.02608338
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02511374
103VDR_22108803_ChIP-Seq_LS180_Human1.02224756
104CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02210607
105LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01813905
106* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01175564
107* MYB_26560356_Chip-Seq_TH1_Human1.01047594
108MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00696107
109PU_27001747_Chip-Seq_BMDM_Mouse0.99721549
110* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99686086
111SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99292868
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97762749
113* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97523305
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97398149
115GATA2_19941826_ChIP-Seq_K562_Human0.97247497
116ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96664630
117PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96586694
118* MAF_26560356_Chip-Seq_TH1_Human0.94830970
119EGR1_19032775_ChIP-ChIP_M12_Human0.94540889
120GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93985655
121RXR_22158963_ChIP-Seq_LIVER_Mouse0.93881414
122SPI1_23127762_ChIP-Seq_K562_Human0.93389310
123* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93388232
124GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92491319
125PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91674862
126VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91398895
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91396332
128RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90979661
129CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90674068
130TFEB_21752829_ChIP-Seq_HELA_Human0.90123876
131CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89948042
132RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89248592
133PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89209375
134VDR_21846776_ChIP-Seq_THP-1_Human0.88926486
135CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88776930
136PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88764901
137GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88736779
138KDM2B_26808549_Chip-Seq_JURKAT_Human0.88682461
139* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.88522635
140NCOR1_26117541_ChIP-Seq_K562_Human0.86013432
141FOXA1_21572438_ChIP-Seq_LNCaP_Human0.85391565
142GABP_17652178_ChIP-ChIP_JURKAT_Human0.84946320
143TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84508311
144SOX17_20123909_ChIP-Seq_XEN_Mouse0.84283813
145STAT1_20625510_ChIP-Seq_HELA_Human0.84252128
146TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82330249
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81633044
148CREB1_15753290_ChIP-ChIP_HEK293T_Human0.81389741
149TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.77302338
150IKZF1_21737484_ChIP-ChIP_HCT116_Human0.73965995
151FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.73282933
152RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72485491
153* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.71296207
154SMRT_27268052_Chip-Seq_Bcells_Human0.69306181
155PPARA_22158963_ChIP-Seq_LIVER_Mouse0.69227446

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.98530217
2MP0003950_abnormal_plasma_membrane3.63149811
3MP0003690_abnormal_glial_cell3.57354736
4MP0006082_CNS_inflammation2.48337697
5MP0010678_abnormal_skin_adnexa2.47194717
6MP0005451_abnormal_body_composition2.35601113
7MP0003806_abnormal_nucleotide_metabolis2.33559694
8MP0005058_abnormal_lysosome_morphology2.28078321
9MP0003329_amyloid_beta_deposits2.27852229
10MP0000383_abnormal_hair_follicle2.22049374
11MP0003656_abnormal_erythrocyte_physiolo2.15320244
12MP0004147_increased_porphyrin_level2.10877545
13MP0001661_extended_life_span2.06222250
14MP0003828_pulmonary_edema2.01094837
15MP0003724_increased_susceptibility_to1.99018961
16MP0001790_abnormal_immune_system1.96490594
17MP0005387_immune_system_phenotype1.96490594
18MP0005671_abnormal_response_to1.94599992
19MP0000465_gastrointestinal_hemorrhage1.92958305
20MP0003634_abnormal_glial_cell1.91232575
21MP0000604_amyloidosis1.90775150
22MP0004885_abnormal_endolymph1.87888006
23MP0009840_abnormal_foam_cell1.87376245
24MP0003195_calcinosis1.87371221
25MP0004381_abnormal_hair_follicle1.85654401
26MP0001851_eye_inflammation1.84159255
27MP0005000_abnormal_immune_tolerance1.83283328
28MP0005409_darkened_coat_color1.77453734
29MP0003300_gastrointestinal_ulcer1.76873263
30MP0001905_abnormal_dopamine_level1.74583682
31MP0004510_myositis1.71695720
32MP0000685_abnormal_immune_system1.71548365
33MP0001835_abnormal_antigen_presentation1.68299678
34MP0003303_peritoneal_inflammation1.67179019
35MP0004742_abnormal_vestibular_system1.65609019
36MP0008260_abnormal_autophagy1.62366038
37MP0001485_abnormal_pinna_reflex1.59586307
38MP0003172_abnormal_lysosome_physiology1.57755684
39MP0002933_joint_inflammation1.56543454
40MP0005025_abnormal_response_to1.54814048
41MP0001800_abnormal_humoral_immune1.54237864
42MP0002998_abnormal_bone_remodeling1.53923671
43MP0004185_abnormal_adipocyte_glucose1.52304587
44MP0005408_hypopigmentation1.51903912
45MP0008004_abnormal_stomach_pH1.51007955
46* MP0002723_abnormal_immune_serum1.50896314
47* MP0002419_abnormal_innate_immunity1.49223163
48MP0004134_abnormal_chest_morphology1.48886192
49MP0000343_altered_response_to1.46187467
50MP0003183_abnormal_peptide_metabolism1.43402496
51MP0000462_abnormal_digestive_system1.43226813
52MP0003136_yellow_coat_color1.40550929
53MP0001853_heart_inflammation1.38385719
54MP0003866_abnormal_defecation1.34214800
55* MP0002420_abnormal_adaptive_immunity1.34119410
56* MP0002452_abnormal_antigen_presenting1.33480511
57MP0003632_abnormal_nervous_system1.32716313
58MP0000703_abnormal_thymus_morphology1.31972145
59MP0000858_altered_metastatic_potential1.31169224
60MP0002148_abnormal_hypersensitivity_rea1.31018248
61MP0005310_abnormal_salivary_gland1.30581553
62* MP0001819_abnormal_immune_cell1.30087979
63MP0009333_abnormal_splenocyte_physiolog1.27346691
64MP0001529_abnormal_vocalization1.25862701
65MP0002877_abnormal_melanocyte_morpholog1.23819939
66MP0005397_hematopoietic_system_phenotyp1.23664641
67MP0001545_abnormal_hematopoietic_system1.23664641
68MP0005171_absent_coat_pigmentation1.22726231
69MP0005166_decreased_susceptibility_to1.22210342
70MP0009785_altered_susceptibility_to1.22109661
71MP0009764_decreased_sensitivity_to1.20750687
72MP0002138_abnormal_hepatobiliary_system1.18715432
73MP0000747_muscle_weakness1.18543646
74MP0008438_abnormal_cutaneous_collagen1.18443908
75MP0002229_neurodegeneration1.17849162
76MP0009278_abnormal_bone_marrow1.17444384
77MP0000647_abnormal_sebaceous_gland1.11159594
78* MP0000716_abnormal_immune_system1.10593266
79MP0002006_tumorigenesis1.09112648
80MP0003448_altered_tumor_morphology1.07159269
81MP0003091_abnormal_cell_migration1.06471544
82MP0003045_fibrosis1.03974450
83MP0002166_altered_tumor_susceptibility1.02751692
84MP0004883_abnormal_blood_vessel1.01394014
85MP0004142_abnormal_muscle_tone1.00965441
86MP0002132_abnormal_respiratory_system0.99702697
87MP0001533_abnormal_skeleton_physiology0.99105858
88MP0004808_abnormal_hematopoietic_stem0.95275390
89MP0001346_abnormal_lacrimal_gland0.95264844
90MP0005584_abnormal_enzyme/coenzyme_acti0.94214163
91MP0002295_abnormal_pulmonary_circulatio0.93775972
92MP0003453_abnormal_keratinocyte_physiol0.93504345
93MP0005164_abnormal_response_to0.91707262
94MP0002405_respiratory_system_inflammati0.90535885
95MP0004043_abnormal_pH_regulation0.87704025
96MP0000249_abnormal_blood_vessel0.87672220
97MP0003186_abnormal_redox_activity0.86479722
98MP0002118_abnormal_lipid_homeostasis0.85864919
99MP0004270_analgesia0.84233564
100* MP0002398_abnormal_bone_marrow0.84115397
101MP0003075_altered_response_to0.83986888
102MP0008469_abnormal_protein_level0.83266417
103MP0004947_skin_inflammation0.83029173
104MP0003763_abnormal_thymus_physiology0.82946379
105MP0005083_abnormal_biliary_tract0.82495988
106MP0000003_abnormal_adipose_tissue0.82480679
107MP0001845_abnormal_inflammatory_respons0.81189131
108MP0000377_abnormal_hair_follicle0.81165349
109MP0009765_abnormal_xenobiotic_induced0.80567310
110MP0008875_abnormal_xenobiotic_pharmacok0.80466193
111MP0001727_abnormal_embryo_implantation0.80035620
112MP0003436_decreased_susceptibility_to0.79998856
113MP0000689_abnormal_spleen_morphology0.79842564
114* MP0002429_abnormal_blood_cell0.79710289
115MP0008874_decreased_physiological_sensi0.79293904
116MP0005464_abnormal_platelet_physiology0.79048296
117MP0003221_abnormal_cardiomyocyte_apopto0.76929968
118MP0001958_emphysema0.76341881
119MP0005666_abnormal_adipose_tissue0.75934713
120MP0004130_abnormal_muscle_cell0.75609494
121MP0009384_cardiac_valve_regurgitation0.74657761
122MP0002009_preneoplasia0.73874786
123MP0001663_abnormal_digestive_system0.73826715
124MP0001666_abnormal_nutrient_absorption0.73027716
125MP0002396_abnormal_hematopoietic_system0.72536037
126MP0003191_abnormal_cellular_cholesterol0.71934659
127MP0003795_abnormal_bone_structure0.71754648
128MP0010155_abnormal_intestine_physiology0.70982435
129MP0004084_abnormal_cardiac_muscle0.70834320
130MP0009115_abnormal_fat_cell0.68292229
131MP0001299_abnormal_eye_distance/0.68226679
132MP0005410_abnormal_fertilization0.68124836
133MP0008057_abnormal_DNA_replication0.67502365
134MP0000015_abnormal_ear_pigmentation0.66315630
135MP0002722_abnormal_immune_system0.66054201
136MP0005381_digestive/alimentary_phenotyp0.66019595
137MP0001873_stomach_inflammation0.65720507
138MP0009763_increased_sensitivity_to0.65042248
139MP0005390_skeleton_phenotype0.64833420
140MP0004036_abnormal_muscle_relaxation0.61112766
141MP0002277_abnormal_respiratory_mucosa0.60250876
142MP0004484_altered_response_of0.59331514
143MP0002332_abnormal_exercise_endurance0.58867847
144MP0000609_abnormal_liver_physiology0.58544574
145MP0000490_abnormal_crypts_of0.58352561

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.35858643
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.35858643
3Neurofibrillary tangles (HP:0002185)5.86993389
4Sensory axonal neuropathy (HP:0003390)5.27443157
5Parakeratosis (HP:0001036)4.93948493
6Abnormality of the corticospinal tract (HP:0002492)4.19552511
7Cerebral inclusion bodies (HP:0100314)4.04151614
8Spontaneous hematomas (HP:0007420)4.02638754
9Peripheral hypomyelination (HP:0007182)4.00203078
10Myositis (HP:0100614)3.78069875
11Recurrent gram-negative bacterial infections (HP:0005420)3.65183176
12Onion bulb formation (HP:0003383)3.61695754
13Orchitis (HP:0100796)3.60903591
14Mediastinal lymphadenopathy (HP:0100721)3.52400307
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.50560724
16Recurrent fungal infections (HP:0002841)3.49789286
17Retrobulbar optic neuritis (HP:0100654)3.44982950
18Optic neuritis (HP:0100653)3.44982950
19Meningitis (HP:0001287)3.44951444
20Prolonged bleeding time (HP:0003010)3.37176811
21Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.36082102
22Cerebral hypomyelination (HP:0006808)3.36024648
23Vasculitis (HP:0002633)3.34015082
24Termporal pattern (HP:0011008)3.26396272
25Insidious onset (HP:0003587)3.26396272
26Premature skin wrinkling (HP:0100678)3.24497578
27Chronic obstructive pulmonary disease (HP:0006510)3.21357958
28Obstructive lung disease (HP:0006536)3.21357958
29Hepatosplenomegaly (HP:0001433)3.20676668
30Gastrointestinal infarctions (HP:0005244)3.18565261
31Abnormal auditory evoked potentials (HP:0006958)3.16928124
32Spastic paraparesis (HP:0002313)3.15517962
33Chronic otitis media (HP:0000389)3.11122851
34Abnormal delayed hypersensitivity skin test (HP:0002963)3.07806450
35Slow saccadic eye movements (HP:0000514)3.04943207
36Cerebral hemorrhage (HP:0001342)3.01985580
37Abnormality of glycolipid metabolism (HP:0010969)3.01536677
38Abnormality of liposaccharide metabolism (HP:0010968)3.01536677
39Recurrent cutaneous fungal infections (HP:0011370)3.00227474
40Chronic mucocutaneous candidiasis (HP:0002728)3.00227474
41Autoamputation (HP:0001218)2.99342147
42Epistaxis (HP:0000421)2.99205488
43Petechiae (HP:0000967)2.95557312
44Stridor (HP:0010307)2.91847922
45Spastic gait (HP:0002064)2.91043450
46Intention tremor (HP:0002080)2.89855996
47Gingivitis (HP:0000230)2.85850560
48Pulmonary infiltrates (HP:0002113)2.85303501
49Encephalitis (HP:0002383)2.85171188
50Urticaria (HP:0001025)2.83859911
51Abnormality of glycolysis (HP:0004366)2.83180048
52Increased serum pyruvate (HP:0003542)2.83180048
53Increased IgE level (HP:0003212)2.83044478
54Congenital ichthyosiform erythroderma (HP:0007431)2.80213170
55Segmental peripheral demyelination/remyelination (HP:0003481)2.78309897
56Keratoconjunctivitis sicca (HP:0001097)2.71809149
57Akinesia (HP:0002304)2.70446620
58Supranuclear gaze palsy (HP:0000605)2.70320048
59Anteriorly placed anus (HP:0001545)2.69838248
60Chest pain (HP:0100749)2.62248196
61Systemic lupus erythematosus (HP:0002725)2.59763285
62Abnormality of macrophages (HP:0004311)2.59037826
63Hemoptysis (HP:0002105)2.57257482
64Inflammation of the large intestine (HP:0002037)2.55611291
65Abnormality of T cells (HP:0002843)2.52983264
66Osteomyelitis (HP:0002754)2.50479939
67Increased IgM level (HP:0003496)2.50366692
68Axonal loss (HP:0003447)2.50348401
69Autoimmune hemolytic anemia (HP:0001890)2.49168651
70T lymphocytopenia (HP:0005403)2.46094013
71Agammaglobulinemia (HP:0004432)2.45599911
72Gastrointestinal inflammation (HP:0004386)2.43289879
73Elevated erythrocyte sedimentation rate (HP:0003565)2.40046719
74Thickened helices (HP:0000391)2.39804820
75Recurrent skin infections (HP:0001581)2.38055578
76Keratoconjunctivitis (HP:0001096)2.37887425
77Arterial thrombosis (HP:0004420)2.37279086
78Leukocytosis (HP:0001974)2.35936216
79Stomatitis (HP:0010280)2.35816032
80Retinal dysplasia (HP:0007973)2.35533781
81Gastrointestinal stroma tumor (HP:0100723)2.34804076
82Colitis (HP:0002583)2.34046429
83Osteolytic defects of the phalanges of the hand (HP:0009771)2.31573668
84Osteolytic defects of the hand bones (HP:0009699)2.31573668
85Abnormality of T cell number (HP:0011839)2.30211834
86Abnormality of aromatic amino acid family metabolism (HP:0004338)2.28934700
87Panhypogammaglobulinemia (HP:0003139)2.28064185
88Leukodystrophy (HP:0002415)2.26836311
89Lymphopenia (HP:0001888)2.26587030
90Alacrima (HP:0000522)2.24981778
91Granulocytopenia (HP:0001913)2.24786762
92Abnormal platelet volume (HP:0011876)2.24653446
93Scanning speech (HP:0002168)2.24222318
94Hyperlipoproteinemia (HP:0010980)2.23174371
95Recurrent bronchitis (HP:0002837)2.22980544
96Pustule (HP:0200039)2.21833552
97Dysmetria (HP:0001310)2.20088528
98Purpura (HP:0000979)2.18840200
99Clumsiness (HP:0002312)2.18545728
100Hypergammaglobulinemia (HP:0010702)2.17146515
101Paraparesis (HP:0002385)2.16553903
102Papilledema (HP:0001085)2.15711158
103Abnormality of cells of the lymphoid lineage (HP:0012140)2.15538031
104Chronic diarrhea (HP:0002028)2.15206288
105Fatigue (HP:0012378)2.15121586
106Polycythemia (HP:0001901)2.13903856
107Peripheral demyelination (HP:0011096)2.11778804
108Autoimmune thrombocytopenia (HP:0001973)2.10920396
109Prolonged neonatal jaundice (HP:0006579)2.10856245
110Episodic fever (HP:0001954)2.07452621
111Intrahepatic cholestasis (HP:0001406)2.06931081
112Increased cerebral lipofuscin (HP:0011813)2.06103150
113Abnormality of the vasculature of the conjunctiva (HP:0008054)2.05535636
114CNS hypomyelination (HP:0003429)2.03501292
115Patchy hypopigmentation of hair (HP:0011365)2.02930728
116Hypoplastic pelvis (HP:0008839)2.02864018
117Anorexia (HP:0002039)2.02846238
118Erythroderma (HP:0001019)2.02602464
119Progressive neurologic deterioration (HP:0002344)1.97914960
120Joint swelling (HP:0001386)1.97676411
121Verrucae (HP:0200043)1.97230770
122Papilloma (HP:0012740)1.97230770
123Gangrene (HP:0100758)1.96633749
124Abnormality of T cell physiology (HP:0011840)1.96370421
125Hematochezia (HP:0002573)1.94581981
126Skin ulcer (HP:0200042)1.94181071
127Eosinophilia (HP:0001880)1.92895061
128Barrel-shaped chest (HP:0001552)1.92639738
129Emphysema (HP:0002097)1.92370002
130Vacuolated lymphocytes (HP:0001922)1.91852727
131Recurrent abscess formation (HP:0002722)1.91019218
132Pulmonary embolism (HP:0002204)1.89759462
133Hypokalemic alkalosis (HP:0001949)1.88913802
134Loss of speech (HP:0002371)1.88662609
135Recurrent bacterial skin infections (HP:0005406)1.88506158
136Spastic tetraparesis (HP:0001285)1.87416359
137Cellulitis (HP:0100658)1.87269289
138Amyloidosis (HP:0011034)1.87047938
139Sepsis (HP:0100806)1.86981974
140Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86724016
141White forelock (HP:0002211)1.85964016
142Microcytic anemia (HP:0001935)1.85786118
143Abnormality of the endocardium (HP:0004306)1.84976441
144Disinhibition (HP:0000734)1.84886705
145Impaired platelet aggregation (HP:0003540)1.84826125
146Abnormal platelet function (HP:0011869)1.84826125
147Increased circulating renin level (HP:0000848)1.84532921
148Abnormality of the peritoneum (HP:0002585)1.84295537
149Polyneuropathy (HP:0001271)1.83980160
150Mucosal telangiectasiae (HP:0100579)1.82823562
151Increased serum ferritin (HP:0003281)1.82131729
152Postnatal microcephaly (HP:0005484)1.79920199
153Steatorrhea (HP:0002570)1.79730910
154Recurrent viral infections (HP:0004429)1.78201173
155Increased neuronal autofluorescent lipopigment (HP:0002074)1.77202614
156Muscle fiber splitting (HP:0003555)1.76666853
1573-Methylglutaconic aciduria (HP:0003535)1.76506194
158Small epiphyses (HP:0010585)1.76062679
159Infantile muscular hypotonia (HP:0008947)1.75914924
160Eczematoid dermatitis (HP:0000976)1.74532075
161Paralysis (HP:0003470)1.74528439
162Dysostosis multiplex (HP:0000943)1.73845216
163Hypomagnesemia (HP:0002917)1.73102181
164Morphological abnormality of the inner ear (HP:0011390)1.72284007
165Metabolic alkalosis (HP:0200114)1.70114187
166Cupped ear (HP:0000378)1.68440618
167Seborrheic dermatitis (HP:0001051)1.67522398
168Gingival bleeding (HP:0000225)1.67483707
169Decreased lacrimation (HP:0000633)1.66738581
170Cerebellar dysplasia (HP:0007033)1.66098520
171Xanthomatosis (HP:0000991)1.65584591
172Urinary incontinence (HP:0000020)1.65563375
173Ileus (HP:0002595)1.64326997
174Restrictive lung disease (HP:0002091)1.63112191
175Anomalous pulmonary venous return (HP:0010772)1.63089915
176Gowers sign (HP:0003391)1.62630605
177Abnormality of glycosphingolipid metabolism (HP:0004343)1.61954085

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.33807676
2EPHB14.70149307
3RIPK44.66419919
4OXSR14.13068554
5PRPF4B3.14170871
6PBK2.69528953
7MAPKAPK52.39399515
8MAP2K32.38070362
9MET2.29739461
10CDK192.28182966
11WNK42.27164090
12ERN12.22627592
13MST42.18765166
14PKN12.09703606
15BCR2.02316499
16TNIK2.01797569
17FGFR21.97229874
18CLK11.95236265
19MAP4K11.82199053
20SYK1.74956840
21CSNK1A1L1.70568707
22WNK11.68940261
23CSNK1G31.68703274
24TESK21.67391400
25FGR1.63726819
26STK101.60046409
27BMPR21.56387111
28LIMK11.53758701
29MAP3K31.52857104
30BLK1.50400018
31CSNK1G11.46310388
32ITK1.36973280
33NEK91.36372236
34TAOK11.35804010
35TAOK31.33216505
36KSR21.33108456
37SIK31.33092643
38TAOK21.31553601
39MAP3K11.28101812
40IRAK41.27944302
41PRKCQ1.27793296
42JAK21.27612449
43FGFR31.23582191
44GRK61.23012832
45ROCK21.19031143
46MATK1.18686425
47CSF1R1.17439664
48ICK1.17013588
49MAP3K111.16032944
50CSK1.13518644
51UHMK11.13099595
52CSNK1G21.03246952
53TGFBR21.01230284
54MAPK120.98032367
55YES10.95671870
56TXK0.95480177
57IRAK10.94991169
58TNK20.92471184
59NEK60.91378244
60MAPK150.91156067
61CDC42BPA0.89700984
62MAP3K50.89271697
63MARK30.88206960
64NTRK10.87588484
65CAMK2B0.86960078
66CAMKK20.85971144
67KIT0.84875741
68IRAK30.83207560
69LCK0.83092953
70MAP3K130.82165372
71RPS6KA50.81942815
72LRRK20.81544018
73STK240.79591932
74CAMK2D0.70885004
75PRKD10.70482838
76MAP3K140.70239354
77NME20.69917636
78IRAK20.69598450
79MAP3K60.68445829
80MAPK70.68192144
81DMPK0.67940609
82NLK0.67903413
83SGK30.67316205
84TRPM70.65534732
85KDR0.64988666
86HIPK20.64811650
87NUAK10.63813802
88IKBKE0.61515963
89MAP3K20.61481149
90SCYL20.59538795
91TEC0.59500318
92GRK70.58376069
93MELK0.57719006
94TBK10.57111263
95RAF10.56588413
96BTK0.56580313
97SGK20.56457520
98JAK30.56330470
99TRIB30.56172039
100FYN0.55951810
101PNCK0.54950600
102GSK3A0.54802344
103PIM10.54009264
104PDPK10.52870114
105CAMK2G0.52064888
106CDK60.52010753
107STK40.51717102
108TIE10.51215982
109DYRK20.51011982
110TYK20.50908248
111MAP2K20.50004141
112PDGFRB0.49908376
113ERBB40.48783440
114LYN0.47374104
115FES0.46516636
116ZAP700.45876085
117ABL10.45875567
118CDK140.44864370
119TTN0.44852673
120CAMKK10.43945117
121ARAF0.43944553
122MARK20.43908087
123PAK60.43430649
124RPS6KC10.43158973
125RPS6KL10.43158973
126BMPR1B0.42377800
127CDK120.42096927
128MAPK110.42093110
129TYRO30.41594423
130MYLK0.40826785
131EIF2AK30.40399080
132IKBKB0.40216057
133EPHA30.40154664
134RIPK10.40138521
135MAPKAPK20.39991723
136PAK30.39755296
137INSR0.39387707
138MKNK10.38863149
139PRKD20.38514252
140MAP3K80.38491744
141PDK10.37461642
142PIK3CG0.36287040
143RET0.36038072
144CDK40.35449012
145MAPK40.35406702
146BCKDK0.35391862
147SIK10.35387843
148MOS0.33943635
149JAK10.33881440
150FGFR40.33028854
151HCK0.32334834
152SGK2230.31248442
153SGK4940.31248442

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.67811510
2Steroid biosynthesis_Homo sapiens_hsa001005.19884298
3Fatty acid elongation_Homo sapiens_hsa000624.37159655
4Protein export_Homo sapiens_hsa030603.25498107
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.16456602
6Ether lipid metabolism_Homo sapiens_hsa005653.13703755
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.65221416
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.36174700
9Sulfur metabolism_Homo sapiens_hsa009202.15839028
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08094761
11Vitamin B6 metabolism_Homo sapiens_hsa007502.01466827
12Tuberculosis_Homo sapiens_hsa051522.01434957
13Type I diabetes mellitus_Homo sapiens_hsa049402.01098992
14Histidine metabolism_Homo sapiens_hsa003401.80225763
15Viral myocarditis_Homo sapiens_hsa054161.79890381
16Sphingolipid metabolism_Homo sapiens_hsa006001.69837851
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67290775
18Toxoplasmosis_Homo sapiens_hsa051451.62815213
19Acute myeloid leukemia_Homo sapiens_hsa052211.55755759
20Influenza A_Homo sapiens_hsa051641.52560650
21Linoleic acid metabolism_Homo sapiens_hsa005911.52068127
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49357635
23Primary immunodeficiency_Homo sapiens_hsa053401.49234634
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40376261
25Herpes simplex infection_Homo sapiens_hsa051681.38728744
26TNF signaling pathway_Homo sapiens_hsa046681.34941527
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32416280
28* Platelet activation_Homo sapiens_hsa046111.29000414
29Folate biosynthesis_Homo sapiens_hsa007901.26569305
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.25263489
31Autoimmune thyroid disease_Homo sapiens_hsa053201.24424351
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23776643
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23660855
34Butanoate metabolism_Homo sapiens_hsa006501.23098750
35Malaria_Homo sapiens_hsa051441.20554436
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19969360
37Legionellosis_Homo sapiens_hsa051341.19054828
38Hepatitis B_Homo sapiens_hsa051611.18472636
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18385301
40Non-small cell lung cancer_Homo sapiens_hsa052231.16021318
41Arginine and proline metabolism_Homo sapiens_hsa003301.15442953
42Lysosome_Homo sapiens_hsa041421.14011936
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.11648472
44B cell receptor signaling pathway_Homo sapiens_hsa046621.11468793
45Hepatitis C_Homo sapiens_hsa051601.07502408
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06414831
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06176029
48Chronic myeloid leukemia_Homo sapiens_hsa052201.04169335
49Asthma_Homo sapiens_hsa053101.04105540
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96773572
51VEGF signaling pathway_Homo sapiens_hsa043700.95336666
52Fatty acid metabolism_Homo sapiens_hsa012120.94944990
53T cell receptor signaling pathway_Homo sapiens_hsa046600.94179690
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93889405
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.93633679
56Apoptosis_Homo sapiens_hsa042100.93259178
57Glutathione metabolism_Homo sapiens_hsa004800.92173879
58Propanoate metabolism_Homo sapiens_hsa006400.91677154
59Staphylococcus aureus infection_Homo sapiens_hsa051500.91149036
60Endocytosis_Homo sapiens_hsa041440.90431627
61* Renal cell carcinoma_Homo sapiens_hsa052110.90059516
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88541479
63Peroxisome_Homo sapiens_hsa041460.86466858
64Prolactin signaling pathway_Homo sapiens_hsa049170.85842664
65Hematopoietic cell lineage_Homo sapiens_hsa046400.85324302
66African trypanosomiasis_Homo sapiens_hsa051430.82897410
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82304727
68* Neurotrophin signaling pathway_Homo sapiens_hsa047220.81982938
69Graft-versus-host disease_Homo sapiens_hsa053320.80982382
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80872864
71Allograft rejection_Homo sapiens_hsa053300.78917868
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78320341
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.75750232
74Axon guidance_Homo sapiens_hsa043600.74531808
75Pertussis_Homo sapiens_hsa051330.72000938
76* Leukocyte transendothelial migration_Homo sapiens_hsa046700.71928596
77Rheumatoid arthritis_Homo sapiens_hsa053230.69495739
78Epstein-Barr virus infection_Homo sapiens_hsa051690.68286669
79Oxidative phosphorylation_Homo sapiens_hsa001900.67965156
80Viral carcinogenesis_Homo sapiens_hsa052030.67600287
81Amoebiasis_Homo sapiens_hsa051460.66193257
82Shigellosis_Homo sapiens_hsa051310.65669983
83Arachidonic acid metabolism_Homo sapiens_hsa005900.63987542
84Caffeine metabolism_Homo sapiens_hsa002320.63360471
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63164869
86Leishmaniasis_Homo sapiens_hsa051400.62129504
87HTLV-I infection_Homo sapiens_hsa051660.61675239
88Phagosome_Homo sapiens_hsa041450.61603139
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61566323
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61098473
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.60326026
92Non-homologous end-joining_Homo sapiens_hsa034500.59989137
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59974139
94GnRH signaling pathway_Homo sapiens_hsa049120.59474185
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59161676
96Endometrial cancer_Homo sapiens_hsa052130.58179767
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58102059
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.57863528
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56420550
100FoxO signaling pathway_Homo sapiens_hsa040680.55521698
101Insulin resistance_Homo sapiens_hsa049310.54098178
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52877170
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.52822079
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.52474727
105mTOR signaling pathway_Homo sapiens_hsa041500.52144133
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50973587
107HIF-1 signaling pathway_Homo sapiens_hsa040660.50401304
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49373496
109Nitrogen metabolism_Homo sapiens_hsa009100.49350939
110Salmonella infection_Homo sapiens_hsa051320.49205354
111Antigen processing and presentation_Homo sapiens_hsa046120.49159051
112Osteoclast differentiation_Homo sapiens_hsa043800.46242111
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46217199
114* Chemokine signaling pathway_Homo sapiens_hsa040620.46200974
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46181324
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.45964468
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45901176
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.44812611
119Choline metabolism in cancer_Homo sapiens_hsa052310.44294859
120Alzheimers disease_Homo sapiens_hsa050100.43568521
121Thyroid cancer_Homo sapiens_hsa052160.42686011
122Other glycan degradation_Homo sapiens_hsa005110.41814832
123Tight junction_Homo sapiens_hsa045300.41301023
124* MAPK signaling pathway_Homo sapiens_hsa040100.41239459
125Prion diseases_Homo sapiens_hsa050200.41146565
126Complement and coagulation cascades_Homo sapiens_hsa046100.40779319
127Pancreatic cancer_Homo sapiens_hsa052120.39957069
128* Long-term potentiation_Homo sapiens_hsa047200.39482039
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39445408
130Colorectal cancer_Homo sapiens_hsa052100.39078213
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38906857
132Chemical carcinogenesis_Homo sapiens_hsa052040.38870636
133Collecting duct acid secretion_Homo sapiens_hsa049660.38848601
134Regulation of autophagy_Homo sapiens_hsa041400.38625132
135Parkinsons disease_Homo sapiens_hsa050120.38517843
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38015869
137Vitamin digestion and absorption_Homo sapiens_hsa049770.37896701
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37104594
139Inositol phosphate metabolism_Homo sapiens_hsa005620.36766887
140Measles_Homo sapiens_hsa051620.36587787
141Metabolic pathways_Homo sapiens_hsa011000.36581661
142Dorso-ventral axis formation_Homo sapiens_hsa043200.36011141
143Ovarian steroidogenesis_Homo sapiens_hsa049130.35959482
144Glioma_Homo sapiens_hsa052140.34191408
145ErbB signaling pathway_Homo sapiens_hsa040120.33179051
146Prostate cancer_Homo sapiens_hsa052150.32466787
147ECM-receptor interaction_Homo sapiens_hsa045120.32077172
148* Ras signaling pathway_Homo sapiens_hsa040140.32061098
149ABC transporters_Homo sapiens_hsa020100.31749658
150PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30767136
151Fatty acid biosynthesis_Homo sapiens_hsa000610.30751737
152Sulfur relay system_Homo sapiens_hsa041220.29884079
153Fatty acid degradation_Homo sapiens_hsa000710.28346278
154Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28128847

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