RAP1AP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microtubule cytoskeleton organization involved in mitosis (GO:1902850)9.98868989
2protein localization to microtubule cytoskeleton (GO:0072698)9.23779755
3protein localization to cytoskeleton (GO:0044380)7.94508356
4response to gravity (GO:0009629)7.52747361
5regulation of synapse structural plasticity (GO:0051823)6.74506628
6dopamine biosynthetic process (GO:0042416)6.52902028
7skeletal muscle adaptation (GO:0043501)6.10398083
8striated muscle atrophy (GO:0014891)5.96163889
9skeletal muscle tissue regeneration (GO:0043403)5.85124489
10regulation of skeletal muscle contraction (GO:0014819)5.59103128
11protein localization to chromosome (GO:0034502)5.38594544
12phenol-containing compound biosynthetic process (GO:0046189)5.21508785
13negative regulation of muscle hypertrophy (GO:0014741)5.01646054
14muscle atrophy (GO:0014889)4.99338443
15prepulse inhibition (GO:0060134)4.98114486
16serotonin metabolic process (GO:0042428)4.97544948
17response to histamine (GO:0034776)4.91550038
18striatum development (GO:0021756)4.75879125
19muscle filament sliding (GO:0030049)4.72272493
20actin-myosin filament sliding (GO:0033275)4.72272493
21microtubule anchoring (GO:0034453)4.60040635
22response to activity (GO:0014823)4.38591694
23regulation of synaptic transmission, dopaminergic (GO:0032225)4.30693382
24auditory behavior (GO:0031223)4.30686535
25response to inactivity (GO:0014854)4.24557442
26melanin biosynthetic process (GO:0042438)4.22878539
27response to muscle activity (GO:0014850)4.11303208
28dopamine transport (GO:0015872)4.07574399
29catecholamine biosynthetic process (GO:0042423)4.04682343
30catechol-containing compound biosynthetic process (GO:0009713)4.04682343
31response to xenobiotic stimulus (GO:0009410)4.00748138
32secondary metabolite biosynthetic process (GO:0044550)3.99483464
33response to auditory stimulus (GO:0010996)3.96699537
34negative regulation of microtubule polymerization (GO:0031115)3.86659691
35primary amino compound metabolic process (GO:1901160)3.86247307
36melanin metabolic process (GO:0006582)3.86173443
37monoamine transport (GO:0015844)3.78645799
38stress fiber assembly (GO:0043149)3.72078980
39negative regulation of skeletal muscle tissue development (GO:0048642)3.68699397
40actin-mediated cell contraction (GO:0070252)3.66232761
41cellular response to nerve growth factor stimulus (GO:1990090)3.65277411
42response to nerve growth factor (GO:1990089)3.65277411
43brain morphogenesis (GO:0048854)3.64037535
44synaptic transmission, dopaminergic (GO:0001963)3.59708452
45protein K6-linked ubiquitination (GO:0085020)3.37406742
46regulation of dopamine metabolic process (GO:0042053)3.34296267
47regulation of catecholamine metabolic process (GO:0042069)3.34296267
48alternative mRNA splicing, via spliceosome (GO:0000380)3.19446931
49dopamine metabolic process (GO:0042417)3.15358567
50regulation of RIG-I signaling pathway (GO:0039535)3.06516728
51grooming behavior (GO:0007625)3.03427894
52cellular response to dexamethasone stimulus (GO:0071549)3.03148759
53cytidine metabolic process (GO:0046087)3.01114033
54cytidine catabolic process (GO:0006216)3.01114033
55cytidine deamination (GO:0009972)3.01114033
56regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.94413516
57regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.94413516
58tissue regeneration (GO:0042246)2.93538772
59substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.92661362
60substrate-independent telencephalic tangential migration (GO:0021826)2.92661362
61regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.91104996
62neuromuscular process controlling posture (GO:0050884)2.86931756
63nucleoside diphosphate catabolic process (GO:0009134)2.82797466
64phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.80558944
65behavioral response to ethanol (GO:0048149)2.79096311
66response to dexamethasone (GO:0071548)2.74567833
67mRNA transcription from RNA polymerase II promoter (GO:0042789)2.72058493
68activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.67032057
69positive regulation of growth hormone secretion (GO:0060124)2.66281880
70pyrimidine ribonucleoside catabolic process (GO:0046133)2.65398823
71regulation of circadian sleep/wake cycle (GO:0042749)2.62483849
72regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.62483849
73myelin assembly (GO:0032288)2.61984268
74cellular response to nicotine (GO:0071316)2.60691682
75skeletal muscle contraction (GO:0003009)2.59804494
76mechanosensory behavior (GO:0007638)2.59569637
77righting reflex (GO:0060013)2.59396240
78regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.58978775
79negative regulation of T cell mediated immunity (GO:0002710)2.55494401
80positive regulation of hormone biosynthetic process (GO:0046886)2.55116900
81thalamus development (GO:0021794)2.52503904
82actin filament-based movement (GO:0030048)2.50566077
83regulation of centriole replication (GO:0046599)2.50441649
84protein polyglutamylation (GO:0018095)2.48432479
85peristalsis (GO:0030432)2.45987165
86neurofilament cytoskeleton organization (GO:0060052)2.45839216
87granulocyte activation (GO:0036230)2.45265421
88positive regulation of hormone metabolic process (GO:0032352)2.44713172
89negative regulation of neural precursor cell proliferation (GO:2000178)2.42472150
90regulation of renal sodium excretion (GO:0035813)2.41405596
91neurotransmitter uptake (GO:0001504)2.40912477
92cellular response to lithium ion (GO:0071285)2.40724523
93cardiovascular system development (GO:0072358)2.40409312
94oligosaccharide catabolic process (GO:0009313)2.37893640
95sarcoplasmic reticulum calcium ion transport (GO:0070296)2.37649964
96negative regulation of heart rate (GO:0010459)2.36693044
97protein localization to microtubule (GO:0035372)18.4128748
98protein localization to kinetochore (GO:0034501)15.2127598
99attachment of spindle microtubules to kinetochore (GO:0008608)14.5072951
100protein localization to chromosome, centromeric region (GO:0071459)11.5248909

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse6.70718435
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.04955927
3VDR_22108803_ChIP-Seq_LS180_Human5.53138844
4TAF15_26573619_Chip-Seq_HEK293_Human4.36928771
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.24410402
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.02097663
7CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.98129820
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.94254267
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.91855425
10GBX2_23144817_ChIP-Seq_PC3_Human2.50866949
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48833648
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.37511783
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.25179851
14AR_21572438_ChIP-Seq_LNCaP_Human2.25141903
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.16371557
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.10908562
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06077857
18ELK4_26923725_Chip-Seq_MESODERM_Mouse1.97695716
19IRF8_21731497_ChIP-ChIP_J774_Mouse1.94628230
20P53_22127205_ChIP-Seq_FIBROBLAST_Human1.94230182
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88031958
22VDR_24787735_ChIP-Seq_THP-1_Human1.87247758
23FUS_26573619_Chip-Seq_HEK293_Human1.86198334
24EGR1_19032775_ChIP-ChIP_M12_Human1.84060931
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.80278982
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69391409
27SPI1_23127762_ChIP-Seq_K562_Human1.68868094
28ARNT_22903824_ChIP-Seq_MCF-7_Human1.64101819
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48766964
30AHR_22903824_ChIP-Seq_MCF-7_Human1.47112394
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46853417
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46660624
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43425331
34SMAD4_21799915_ChIP-Seq_A2780_Human1.42375666
35P300_19829295_ChIP-Seq_ESCs_Human1.42003343
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.40965196
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34596658
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34378716
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34216737
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33880933
41FLI1_21867929_ChIP-Seq_TH2_Mouse1.30820826
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28179223
43ER_23166858_ChIP-Seq_MCF-7_Human1.27480603
44CJUN_26792858_Chip-Seq_BT549_Human1.26039370
45TAL1_26923725_Chip-Seq_HPCs_Mouse1.24403384
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23965552
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.20836850
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.18498967
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18296163
50NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17473583
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15785008
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.14384448
53EZH2_22144423_ChIP-Seq_EOC_Human1.12789781
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11764341
55TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08727968
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07075963
57TP53_16413492_ChIP-PET_HCT116_Human1.06927950
58CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06530400
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06413279
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05240959
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05107074
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04422689
63KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03450186
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03040349
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01901370
66RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01715628
67CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99895481
68STAT3_23295773_ChIP-Seq_U87_Human0.98604962
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98076327
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97982765
71SALL4_22934838_ChIP-ChIP_CD34+_Human0.96192301
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95361577
73PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94620530
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93488983
75SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93450578
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93180657
77NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91695516
78MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.90977485
79RUNX_20019798_ChIP-Seq_JUKART_Human0.89962590
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89646446
81NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89646446
82BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88699621
83FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88574272
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88341620
85CRX_20693478_ChIP-Seq_RETINA_Mouse0.86367276
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85768241
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83263341
88KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.82979248
89SOX2_21211035_ChIP-Seq_LN229_Gbm0.82805307
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82106443
91PU_27001747_Chip-Seq_BMDM_Mouse0.81051578
92NANOG_19829295_ChIP-Seq_ESCs_Human0.80220563
93SOX2_19829295_ChIP-Seq_ESCs_Human0.80220563
94CDX2_22108803_ChIP-Seq_LS180_Human0.79158192
95OCT1_27270436_Chip-Seq_PROSTATE_Human0.78933944
96TCF4_23295773_ChIP-Seq_U87_Human0.77438961
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.77179525
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76104467
99EZH2_27294783_Chip-Seq_NPCs_Mouse0.75335761
100SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.75267856

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.99622216
2MP0002822_catalepsy4.97335734
3MP0001529_abnormal_vocalization3.49828674
4MP0005408_hypopigmentation3.29213700
5MP0005409_darkened_coat_color3.26576497
6MP0000569_abnormal_digit_pigmentation3.12764073
7MP0002102_abnormal_ear_morphology3.06065551
8MP0002089_abnormal_postnatal_growth/wei2.82101010
9MP0008438_abnormal_cutaneous_collagen2.81840154
10MP0000015_abnormal_ear_pigmentation2.73620520
11MP0002736_abnormal_nociception_after2.67237618
12MP0003705_abnormal_hypodermis_morpholog2.64441088
13MP0000749_muscle_degeneration2.63086075
14MP0001501_abnormal_sleep_pattern2.41407070
15MP0005075_abnormal_melanosome_morpholog2.41356098
16MP0004145_abnormal_muscle_electrophysio2.40974677
17MP0000747_muscle_weakness2.36815003
18MP0001188_hyperpigmentation2.32358693
19MP0001905_abnormal_dopamine_level2.32299265
20MP0002877_abnormal_melanocyte_morpholog2.26593024
21MP0000013_abnormal_adipose_tissue2.10347758
22MP0002095_abnormal_skin_pigmentation2.07622037
23MP0005275_abnormal_skin_tensile2.07387746
24MP0000750_abnormal_muscle_regeneration2.01763317
25MP0003950_abnormal_plasma_membrane1.93007395
26MP0004270_analgesia1.89221040
27MP0002106_abnormal_muscle_physiology1.82408033
28MP0003806_abnormal_nucleotide_metabolis1.81646970
29MP0004381_abnormal_hair_follicle1.70823120
30MP0002269_muscular_atrophy1.62530798
31MP0006276_abnormal_autonomic_nervous1.59202488
32MP0000759_abnormal_skeletal_muscle1.58100479
33MP0005257_abnormal_intraocular_pressure1.55492584
34MP0000751_myopathy1.54461299
35MP0002148_abnormal_hypersensitivity_rea1.45870365
36MP0003786_premature_aging1.44843922
37MP0001486_abnormal_startle_reflex1.43427304
38MP0000733_abnormal_muscle_development1.31315700
39MP0005369_muscle_phenotype1.28141358
40MP0001968_abnormal_touch/_nociception1.25847731
41MP0004742_abnormal_vestibular_system1.24637197
42MP0003959_abnormal_lean_body1.24577449
43MP0006054_spinal_hemorrhage1.23770938
44MP0004510_myositis1.22034723
45MP0005620_abnormal_muscle_contractility1.21765325
46MP0003045_fibrosis1.20981223
47MP0002332_abnormal_exercise_endurance1.20643789
48MP0001243_abnormal_dermal_layer1.18524644
49MP0000427_abnormal_hair_cycle1.17761393
50MP0008004_abnormal_stomach_pH1.14522354
51MP0004087_abnormal_muscle_fiber1.13780962
52MP0004036_abnormal_muscle_relaxation1.13280994
53MP0005167_abnormal_blood-brain_barrier1.12929187
54MP0000358_abnormal_cell_content/1.10363433
55MP0001958_emphysema1.06304452
56MP0001440_abnormal_grooming_behavior1.02274791
57MP0005535_abnormal_body_temperature1.00512939
58MP0001790_abnormal_immune_system1.00050876
59MP0005387_immune_system_phenotype1.00050876
60MP0005083_abnormal_biliary_tract0.98949267
61MP0002090_abnormal_vision0.98880410
62MP0010307_abnormal_tumor_latency0.98133032
63MP0000371_diluted_coat_color0.97819339
64MP0002938_white_spotting0.95699976
65MP0003879_abnormal_hair_cell0.93441089
66MP0004484_altered_response_of0.92170057
67MP0005377_hearing/vestibular/ear_phenot0.88564575
68MP0003878_abnormal_ear_physiology0.88564575
69MP0002796_impaired_skin_barrier0.88212569
70MP0006036_abnormal_mitochondrial_physio0.84789728
71MP0009765_abnormal_xenobiotic_induced0.82429802
72MP0005197_abnormal_uvea_morphology0.81552974
73MP0002108_abnormal_muscle_morphology0.79225448
74MP0003724_increased_susceptibility_to0.78505683
75MP0002067_abnormal_sensory_capabilities0.78220981
76MP0001881_abnormal_mammary_gland0.77998835
77MP0001186_pigmentation_phenotype0.76144204
78MP0005671_abnormal_response_to0.75485191
79MP0005386_behavior/neurological_phenoty0.75055447
80MP0004924_abnormal_behavior0.75055447
81MP0009745_abnormal_behavioral_response0.74468824
82MP0004883_abnormal_blood_vessel0.68632537
83MP0005646_abnormal_pituitary_gland0.68579443
84MP0003303_peritoneal_inflammation0.68247269
85MP0002075_abnormal_coat/hair_pigmentati0.67909119
86MP0009764_decreased_sensitivity_to0.67451140
87MP0000627_abnormal_mammary_gland0.67125345
88MP0006035_abnormal_mitochondrial_morpho0.64241449
89MP0006082_CNS_inflammation0.64224828
90MP0003011_delayed_dark_adaptation0.62911518
91MP0002572_abnormal_emotion/affect_behav0.62373748
92MP0010771_integument_phenotype0.59747646
93MP0008260_abnormal_autophagy0.59500872
94MP0001191_abnormal_skin_condition0.59268953
95MP0002272_abnormal_nervous_system0.57623184
96MP0005248_abnormal_Harderian_gland0.56461434
97MP0005000_abnormal_immune_tolerance0.55800339
98MP0008872_abnormal_physiological_respon0.54108169
99MP0008874_decreased_physiological_sensi0.54064150
100MP0002060_abnormal_skin_morphology0.52929440

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)7.05297964
2Nemaline bodies (HP:0003798)4.82698658
3Mask-like facies (HP:0000298)4.80548952
4Entropion (HP:0000621)4.68245182
5Exercise-induced myalgia (HP:0003738)4.54983469
6Distal arthrogryposis (HP:0005684)4.44428129
7Limb dystonia (HP:0002451)4.35518922
8Neoplasm of the heart (HP:0100544)4.11345076
9Bifid tongue (HP:0010297)3.97821854
10Absent phalangeal crease (HP:0006109)3.76724167
11Muscle fiber inclusion bodies (HP:0100299)3.70142579
12Calcaneovalgus deformity (HP:0001848)3.70111365
13Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.66713001
14Hypopigmentation of the fundus (HP:0007894)3.45492112
15Generalized hypopigmentation (HP:0007513)3.41518007
16Round ear (HP:0100830)3.37305503
17Abnormal finger flexion creases (HP:0006143)3.35079168
18Periorbital edema (HP:0100539)3.31514580
19Facial edema (HP:0000282)3.26013888
20Poikiloderma (HP:0001029)3.25857483
21Large for gestational age (HP:0001520)3.17424944
22Deformed tarsal bones (HP:0008119)3.16959411
23Acute necrotizing encephalopathy (HP:0006965)3.16264407
24Exercise-induced muscle cramps (HP:0003710)3.02830928
25Orthostatic hypotension (HP:0001278)3.02765441
26Dyschromatopsia (HP:0007641)3.00808289
27Hyperkalemia (HP:0002153)2.99128344
28Progressive macrocephaly (HP:0004481)2.95861469
29Acute encephalopathy (HP:0006846)2.92307269
30Ulnar deviation of the wrist (HP:0003049)2.84732646
31Aplasia/Hypoplasia of the macula (HP:0008059)2.82233713
32Microglossia (HP:0000171)2.82174003
33Amyotrophic lateral sclerosis (HP:0007354)2.78143390
34Abnormality of the axillary hair (HP:0100134)2.74310114
35Abnormality of secondary sexual hair (HP:0009888)2.74310114
36Ocular albinism (HP:0001107)2.74306961
37Iris hypopigmentation (HP:0007730)2.74188012
38Abnormality of lateral ventricle (HP:0030047)2.67246668
39Aplasia/Hypoplasia affecting the retina (HP:0008061)2.64109647
40Abnormal auditory evoked potentials (HP:0006958)2.62254089
41Visual hallucinations (HP:0002367)2.59273269
42Type 1 muscle fiber predominance (HP:0003803)2.54171140
43Paralysis (HP:0003470)2.48174484
44Volvulus (HP:0002580)2.43919154
45Abnormal mitochondria in muscle tissue (HP:0008316)2.43268057
46Enlarged kidneys (HP:0000105)2.39766612
47Myotonia (HP:0002486)2.33827475
48Myoglobinuria (HP:0002913)2.28819999
49Abnormality of the peritoneum (HP:0002585)2.27274446
50Ectropion (HP:0000656)2.26378400
51Reduced antithrombin III activity (HP:0001976)2.25324898
52Renal dysplasia (HP:0000110)2.24438113
53Keratitis (HP:0000491)2.22131892
54Frequent falls (HP:0002359)2.12552898
55Cutaneous melanoma (HP:0012056)2.12341959
56Nonprogressive disorder (HP:0003680)2.09202153
57Dysautonomia (HP:0002459)2.05182266
58Lip pit (HP:0100267)2.03704174
59Abnormality of binocular vision (HP:0011514)2.03190564
60Diplopia (HP:0000651)2.03190564
61Congenital sensorineural hearing impairment (HP:0008527)2.01446868
62Corneal dystrophy (HP:0001131)2.00180260
63Difficulty running (HP:0009046)1.99943858
64Aplasia/Hypoplasia of the fibula (HP:0006492)1.98453643
65Albinism (HP:0001022)1.90608317
66Hypoplastic ischia (HP:0003175)1.90126202
67Hypoplasia of the uterus (HP:0000013)1.88822769
68Cortical visual impairment (HP:0100704)1.88709333
69Abnormality of the renal collecting system (HP:0004742)1.88389079
70Polyphagia (HP:0002591)1.87455745
71Decreased subcutaneous fat (HP:0001002)1.87205969
72Fatigue (HP:0012378)1.86191187
73Erythroderma (HP:0001019)1.83566158
74Mitochondrial inheritance (HP:0001427)1.83491854
75Abnormality of the fovea (HP:0000493)1.83461983
76Hyperalaninemia (HP:0003348)1.83431287
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83431287
78Abnormality of alanine metabolism (HP:0010916)1.83431287
79Mediastinal lymphadenopathy (HP:0100721)1.82464759
80Blue irides (HP:0000635)1.81196651
81Metatarsus adductus (HP:0001840)1.81099198
82Median cleft lip (HP:0000161)1.80598459
83Arthropathy (HP:0003040)1.78133181
84Rimmed vacuoles (HP:0003805)1.78005376
85Atrophy/Degeneration involving motor neurons (HP:0007373)1.76365580
86Fibular hypoplasia (HP:0003038)1.76076150
87Short tibia (HP:0005736)1.75950081
88Cerebral edema (HP:0002181)1.74514169
89Abnormality of potassium homeostasis (HP:0011042)1.72659190
90Abnormality of the septum pellucidum (HP:0007375)1.70081937
91Joint swelling (HP:0001386)1.70019435
92Personality changes (HP:0000751)1.69612839
93Mutism (HP:0002300)1.69403938
94Recurrent corneal erosions (HP:0000495)1.66679209
95Abnormality of the clitoris (HP:0000056)1.66035986
96Abnormality of the pubic bones (HP:0003172)1.65991051
97Intellectual disability, moderate (HP:0002342)1.65849844
98Disinhibition (HP:0000734)1.64683265
99Delayed gross motor development (HP:0002194)1.63363215
100Focal motor seizures (HP:0011153)1.63060514

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K128.00113114
2MAP3K114.47248975
3SIK13.17445972
4PHKG22.73354078
5PHKG12.73354078
6EIF2AK22.63177520
7MAPK132.50991754
8MARK12.47628323
9TAOK12.29852194
10MAPKAPK31.96839893
11MST1R1.79769129
12FES1.63599630
13TYRO31.62883613
14TAOK21.62849204
15OBSCN1.54961335
16LIMK11.45309559
17CSF1R1.42141173
18MATK1.35241968
19TIE11.28692951
20MAP3K11.27727424
21TESK11.24286167
22MAP3K51.23932724
23CHEK21.22012246
24MAP3K91.18536883
25MST41.15084584
26GRK51.14193711
27GRK71.11228550
28PTK2B1.09751494
29TGFBR21.09576923
30CAMK2A1.07654684
31CSNK1G31.06834068
32DAPK11.02769373
33FGR1.02219628
34MAP2K41.00897234
35CAMK1D1.00861317
36DYRK20.97128027
37SIK30.95446402
38CSNK1A1L0.95112349
39NTRK10.94618505
40CSNK1G10.91207663
41IKBKB0.88777732
42DYRK1A0.88734418
43DMPK0.88424071
44GRK60.87646634
45CAMKK20.87548108
46MAP3K30.86008215
47IRAK30.84353826
48TAF10.83710500
49BRD40.82635634
50CHUK0.79829222
51CSK0.77840630
52MYLK0.77532069
53CAMK2G0.77508740
54NME20.77108030
55IRAK20.74888562
56UHMK10.74086290
57CSNK1G20.73254111
58ADRBK20.71001374
59ADRBK10.69659190
60FGFR20.64228076
61BUB10.63335381
62ILK0.61552083
63SYK0.60554737
64PRKG10.58177973
65MAP2K70.58017217
66DAPK20.56812527
67JAK10.56378733
68STK160.53875689
69PIK3CA0.53330344
70CDK30.53220189
71MAP2K30.52576672
72MAPK40.52178985
73CAMK2B0.51931105
74DYRK30.50945811
75AURKA0.48610678
76WNK30.47757749
77TXK0.47096380
78FYN0.44429089
79PIK3CG0.43226194
80CDK180.40840112
81PDK20.40561045
82CDK150.40095365
83JAK30.38529400
84NEK90.38488006
85MAPK120.37694083
86DDR20.37241980
87PRKACB0.36962944
88CDK140.36849618
89FER0.36116271
90YES10.35577362
91IRAK10.35542370
92CSNK1D0.34331695
93CDK11A0.33874773
94KDR0.32881746
95PLK20.32084079
96CAMK1G0.32039075
97MARK30.30715746
98PRKCE0.29323929
99STK100.29269371
100MAPK70.29077044

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.26195057
2Protein export_Homo sapiens_hsa030603.03290507
3Parkinsons disease_Homo sapiens_hsa050122.51171817
4Tight junction_Homo sapiens_hsa045302.32876861
5Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.25628133
6Serotonergic synapse_Homo sapiens_hsa047262.25421418
7Allograft rejection_Homo sapiens_hsa053302.23274072
8Regulation of autophagy_Homo sapiens_hsa041402.12001652
9Proteasome_Homo sapiens_hsa030502.07648555
10Nitrogen metabolism_Homo sapiens_hsa009102.06028720
11Nicotine addiction_Homo sapiens_hsa050331.99963960
12Antigen processing and presentation_Homo sapiens_hsa046121.97303857
13Cocaine addiction_Homo sapiens_hsa050301.88667753
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72416179
15Alzheimers disease_Homo sapiens_hsa050101.72204967
16Pentose phosphate pathway_Homo sapiens_hsa000301.61549561
17Oxidative phosphorylation_Homo sapiens_hsa001901.44968201
18Chemical carcinogenesis_Homo sapiens_hsa052041.43343572
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.42304703
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40983519
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39496973
22Autoimmune thyroid disease_Homo sapiens_hsa053201.33531778
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26085588
24Tryptophan metabolism_Homo sapiens_hsa003801.25292904
25Amphetamine addiction_Homo sapiens_hsa050311.24312461
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.23758724
27Circadian entrainment_Homo sapiens_hsa047131.20810360
28Measles_Homo sapiens_hsa051621.20785839
29Dopaminergic synapse_Homo sapiens_hsa047281.16668327
30Histidine metabolism_Homo sapiens_hsa003401.15801394
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15149764
32Type I diabetes mellitus_Homo sapiens_hsa049401.12007659
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11754948
34Salmonella infection_Homo sapiens_hsa051321.09550445
35Adherens junction_Homo sapiens_hsa045201.09457427
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06285892
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.05909207
38Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.04220531
39Malaria_Homo sapiens_hsa051441.01979419
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01697092
41Phagosome_Homo sapiens_hsa041451.01174318
42Legionellosis_Homo sapiens_hsa051341.00354258
43Rheumatoid arthritis_Homo sapiens_hsa053230.98705026
44Herpes simplex infection_Homo sapiens_hsa051680.97221847
45Chemokine signaling pathway_Homo sapiens_hsa040620.96117291
46GABAergic synapse_Homo sapiens_hsa047270.95759798
47Olfactory transduction_Homo sapiens_hsa047400.94726412
48Calcium signaling pathway_Homo sapiens_hsa040200.94322803
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92359804
50Endocytosis_Homo sapiens_hsa041440.90888363
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89790217
52Osteoclast differentiation_Homo sapiens_hsa043800.88731468
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87062484
54Platelet activation_Homo sapiens_hsa046110.87049174
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85957273
56Glutathione metabolism_Homo sapiens_hsa004800.82408153
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81838011
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80995552
59MAPK signaling pathway_Homo sapiens_hsa040100.80313230
60Oxytocin signaling pathway_Homo sapiens_hsa049210.79666936
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77196442
62Gap junction_Homo sapiens_hsa045400.74973999
63T cell receptor signaling pathway_Homo sapiens_hsa046600.74572313
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74491056
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74301252
66Huntingtons disease_Homo sapiens_hsa050160.73493680
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73409002
68Galactose metabolism_Homo sapiens_hsa000520.71911659
69Fructose and mannose metabolism_Homo sapiens_hsa000510.71106857
70Morphine addiction_Homo sapiens_hsa050320.70500000
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69008481
72Amoebiasis_Homo sapiens_hsa051460.67889465
73Lysosome_Homo sapiens_hsa041420.66566643
74Gastric acid secretion_Homo sapiens_hsa049710.65338761
75African trypanosomiasis_Homo sapiens_hsa051430.65207878
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63997484
77Renin secretion_Homo sapiens_hsa049240.63867408
78Epstein-Barr virus infection_Homo sapiens_hsa051690.61897827
79Cardiac muscle contraction_Homo sapiens_hsa042600.59289606
80Shigellosis_Homo sapiens_hsa051310.58492938
81HIF-1 signaling pathway_Homo sapiens_hsa040660.55869182
82Asthma_Homo sapiens_hsa053100.54826110
83Tuberculosis_Homo sapiens_hsa051520.53896679
84Systemic lupus erythematosus_Homo sapiens_hsa053220.52682235
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52638668
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51128085
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50010447
88Basal transcription factors_Homo sapiens_hsa030220.49763445
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49296794
90Dilated cardiomyopathy_Homo sapiens_hsa054140.47702130
91Renal cell carcinoma_Homo sapiens_hsa052110.46837511
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44262100
93Hematopoietic cell lineage_Homo sapiens_hsa046400.43960463
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43338094
95Alcoholism_Homo sapiens_hsa050340.41925379
96Long-term potentiation_Homo sapiens_hsa047200.41840238
97Wnt signaling pathway_Homo sapiens_hsa043100.40847294
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40820350
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37233240
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.35447293

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