RAP1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA methylation (GO:0031167)8.05542894
2rRNA modification (GO:0000154)6.98167895
3positive regulation of granulocyte differentiation (GO:0030854)6.14750091
4thrombin receptor signaling pathway (GO:0070493)5.42557002
5negative regulation of granulocyte differentiation (GO:0030853)5.26830975
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.24512123
7definitive hemopoiesis (GO:0060216)4.93342627
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.86232072
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.86232072
10regulation of platelet aggregation (GO:0090330)4.79833695
11regulation of inositol phosphate biosynthetic process (GO:0010919)4.70488381
12G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.60984762
13antigen processing and presentation of endogenous antigen (GO:0019883)4.54900096
14positive regulation of gamma-delta T cell activation (GO:0046645)4.37498633
15negative regulation of norepinephrine secretion (GO:0010700)4.28185380
16embryonic process involved in female pregnancy (GO:0060136)4.16375577
17positive regulation by symbiont of host defense response (GO:0052509)4.07225561
18modulation by symbiont of host defense response (GO:0052031)4.07225561
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.07225561
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.07225561
21positive regulation by organism of defense response of other organism involved in symbiotic interact4.07225561
22modulation by symbiont of host immune response (GO:0052553)4.07225561
23neutrophil activation involved in immune response (GO:0002283)4.05331981
24megakaryocyte development (GO:0035855)3.98627852
25regulation of T-helper 1 cell differentiation (GO:0045625)3.95459088
26regulation of granulocyte differentiation (GO:0030852)3.94446537
27regulation of platelet activation (GO:0010543)3.92184306
28regulation of female gonad development (GO:2000194)3.74619148
29negative regulation of homotypic cell-cell adhesion (GO:0034111)3.71286493
30granulocyte differentiation (GO:0030851)3.66847228
31positive regulation of steroid hormone secretion (GO:2000833)3.65406348
32regulation of B cell receptor signaling pathway (GO:0050855)3.59899632
33positive regulation of alpha-beta T cell proliferation (GO:0046641)3.59183422
34Arp2/3 complex-mediated actin nucleation (GO:0034314)3.57470789
35regulation of interleukin-12 biosynthetic process (GO:0045075)3.52567264
36regulation of interferon-alpha production (GO:0032647)3.39514102
37positive regulation of interferon-alpha production (GO:0032727)3.38602898
38immunoglobulin mediated immune response (GO:0016064)3.37177772
39purinergic nucleotide receptor signaling pathway (GO:0035590)3.34278944
40regulation of gamma-delta T cell differentiation (GO:0045586)3.31862814
41adenosine receptor signaling pathway (GO:0001973)3.30232656
42response to peptidoglycan (GO:0032494)3.30008697
43negative regulation of stress fiber assembly (GO:0051497)3.29907258
44regulation of penile erection (GO:0060405)3.28241807
45positive regulation of mast cell activation (GO:0033005)3.27162390
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.26502807
47leukocyte aggregation (GO:0070486)3.26200202
48regulation of interferon-beta biosynthetic process (GO:0045357)3.25227387
49regulation of gamma-delta T cell activation (GO:0046643)3.21951114
50response to pheromone (GO:0019236)3.19576850
51positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.17281210
52regulation of integrin activation (GO:0033623)3.15183823
53regulation of homotypic cell-cell adhesion (GO:0034110)3.14499080
54T cell migration (GO:0072678)3.13449462
55myeloid cell development (GO:0061515)3.08589412
56respiratory burst (GO:0045730)3.06611584
57macrophage activation involved in immune response (GO:0002281)3.05821263
58response to muramyl dipeptide (GO:0032495)3.05219542
59production of molecular mediator involved in inflammatory response (GO:0002532)3.04625506
60regulation of regulatory T cell differentiation (GO:0045589)3.04010171
61JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.03994381
62response to type I interferon (GO:0034340)3.02509213
63positive regulation of macrophage differentiation (GO:0045651)3.02181280
64granulocyte activation (GO:0036230)3.01724763
65myeloid dendritic cell activation (GO:0001773)2.99866304
66neutrophil activation (GO:0042119)2.99795737
67type I interferon signaling pathway (GO:0060337)2.98995490
68cellular response to type I interferon (GO:0071357)2.98995490
69positive regulation of male gonad development (GO:2000020)2.98202947
70interferon-gamma production (GO:0032609)2.97622213
71negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.94327658
72negative regulation of cell killing (GO:0031342)2.94327658
73hepatocyte apoptotic process (GO:0097284)2.93495177
74negative regulation of interleukin-12 production (GO:0032695)2.93263536
75regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.90403545
76antigen processing and presentation via MHC class Ib (GO:0002475)2.88752609
77peripheral nervous system neuron development (GO:0048935)2.87954565
78response to protozoan (GO:0001562)2.87551787
79interferon-gamma-mediated signaling pathway (GO:0060333)2.87457729
80cellular extravasation (GO:0045123)2.87051392
81positive regulation of B cell differentiation (GO:0045579)2.86987256
82positive regulation of isotype switching (GO:0045830)2.85997884
83relaxation of smooth muscle (GO:0044557)2.85698945
84leukocyte cell-cell adhesion (GO:0007159)2.85084640
85protein neddylation (GO:0045116)2.85057806
86defense response to protozoan (GO:0042832)2.83466925
87negative regulation of T cell mediated immunity (GO:0002710)2.83359740
88positive regulation of antigen processing and presentation (GO:0002579)2.81887689
89myeloid dendritic cell differentiation (GO:0043011)2.80085046
90regulation of mast cell activation (GO:0033003)2.76620095
91positive regulation of interleukin-17 production (GO:0032740)2.75737127
92positive regulation of natural killer cell mediated immunity (GO:0002717)2.75682770
93regulation of pigment cell differentiation (GO:0050932)2.74682118
94negative thymic T cell selection (GO:0045060)2.73743616
95NIK/NF-kappaB signaling (GO:0038061)2.73431541
96positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.73367792
97myeloid cell activation involved in immune response (GO:0002275)2.73308367
98positive thymic T cell selection (GO:0045059)2.72489704
99embryonic hemopoiesis (GO:0035162)2.72247079
100B cell mediated immunity (GO:0019724)2.72100816
101positive regulation of interferon-beta production (GO:0032728)2.71303826
102regulation of B cell differentiation (GO:0045577)2.71295608
103negative regulation of platelet activation (GO:0010544)2.70637052
104tolerance induction (GO:0002507)2.70635181
105negative regulation of T cell apoptotic process (GO:0070233)2.70047809
106negative T cell selection (GO:0043383)2.69587703
107lipopolysaccharide-mediated signaling pathway (GO:0031663)2.68229832
108positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.67785851
109regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.67678136
110regulation of natural killer cell mediated immunity (GO:0002715)2.67678136
111positive regulation of interleukin-2 production (GO:0032743)2.67436085
112negative regulation of T-helper cell differentiation (GO:0045623)2.67380523
113negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.67380523
114G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.66534169
115positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.65963409
116actin nucleation (GO:0045010)2.63325838
117response to host immune response (GO:0052572)2.63275296
118response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.63275296
119negative regulation of B cell proliferation (GO:0030889)2.62403759
120regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.61568897
121positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.61439650
122negative regulation of phagocytosis (GO:0050765)2.60054984
123pinocytosis (GO:0006907)2.59663402
124positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.58311657
125endothelium development (GO:0003158)2.57160866
126response to host (GO:0075136)2.56991097
127response to host defenses (GO:0052200)2.56991097
128response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.56991097
129hematopoietic stem cell proliferation (GO:0071425)2.56829172
130positive regulation of natural killer cell differentiation (GO:0032825)2.56628856
131positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.56453122
132COPI coating of Golgi vesicle (GO:0048205)2.55981747
133Golgi transport vesicle coating (GO:0048200)2.55981747
134regulation of cAMP-dependent protein kinase activity (GO:2000479)2.54599058
135B cell receptor signaling pathway (GO:0050853)2.54460704
136leukocyte degranulation (GO:0043299)2.53973124
137positive regulation of T-helper cell differentiation (GO:0045624)2.53777954
138programmed necrotic cell death (GO:0097300)2.53595764
139response to interferon-beta (GO:0035456)2.53060016
140regulation of response to interferon-gamma (GO:0060330)2.52423431
141response to interleukin-15 (GO:0070672)2.52325836
142cellular response to arsenic-containing substance (GO:0071243)2.52240309
143regulation of memory T cell differentiation (GO:0043380)2.52047414
144erythrocyte development (GO:0048821)2.51812774
145positive regulation of B cell mediated immunity (GO:0002714)2.51694327
146positive regulation of immunoglobulin mediated immune response (GO:0002891)2.51694327
147regulation of antigen processing and presentation (GO:0002577)2.51289148
148regulation of interleukin-17 production (GO:0032660)2.48855774
149negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.48114289
150regulation of alpha-beta T cell proliferation (GO:0046640)2.47859549
151endocardial cushion development (GO:0003197)2.47654085
152germinal center formation (GO:0002467)2.47325508
153growth hormone receptor signaling pathway (GO:0060396)2.47104689
154myeloid leukocyte activation (GO:0002274)2.46802326
155regulation of leukocyte mediated cytotoxicity (GO:0001910)2.45593108
156positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.45223141
157signal peptide processing (GO:0006465)2.45092550
158cellular response to interferon-beta (GO:0035458)2.44206705
159regulation of type I interferon-mediated signaling pathway (GO:0060338)2.43755744
160regulation of T-helper 1 type immune response (GO:0002825)2.43612236
161regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.43487969
162autophagic vacuole fusion (GO:0000046)2.43198748
163positive regulation of DNA recombination (GO:0045911)2.41356835
164cellular defense response (GO:0006968)2.41029827
165positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.41005195
166regulation of T cell chemotaxis (GO:0010819)2.40574363
167positive regulation of T cell chemotaxis (GO:0010820)2.40574363
168positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.40374760
169regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.39780172
170negative regulation of actin filament bundle assembly (GO:0032232)2.38253329
171regulation of T cell mediated cytotoxicity (GO:0001914)2.37950831
172necrotic cell death (GO:0070265)2.37732097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.83320554
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.57113994
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.96631351
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.84075694
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.75004324
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.39569784
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.24957382
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.16588058
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.09901152
10* IRF8_27001747_Chip-Seq_BMDM_Mouse3.01816584
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.98951645
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.96018251
13* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.95447610
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.95276515
15* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.82410401
16E2F7_22180533_ChIP-Seq_HELA_Human2.82135234
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.74247611
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54178962
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.48460498
20MYB_26560356_Chip-Seq_TH2_Human2.36031329
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.32863542
22MYC_22102868_ChIP-Seq_BL_Human2.26266484
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24647859
24* SCL_19346495_ChIP-Seq_HPC-7_Human2.24543936
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.24502330
26SPI1_23547873_ChIP-Seq_NB4_Human2.23212659
27* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.19846264
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18938993
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.15206566
30* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14516359
31* RUNX_20019798_ChIP-Seq_JUKART_Human2.04960392
32MAF_26560356_Chip-Seq_TH1_Human2.04013152
33* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03805224
34POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03596105
35* MYB_26560356_Chip-Seq_TH1_Human1.96749388
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.95575058
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.94672963
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93360889
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.85660530
40VDR_21846776_ChIP-Seq_THP-1_Human1.79602063
41VDR_24763502_ChIP-Seq_THP-1_Human1.79266247
42EWS_26573619_Chip-Seq_HEK293_Human1.74177157
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.67247626
44GATA1_22025678_ChIP-Seq_K562_Human1.64694522
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.63494432
46* UTX_26944678_Chip-Seq_JUKART_Human1.63396044
47* TCF7_22412390_ChIP-Seq_EML_Mouse1.58246896
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57103653
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56379385
50* PU_27001747_Chip-Seq_BMDM_Mouse1.55815621
51SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54565575
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52752187
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49085807
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46864990
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46836351
56* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46784421
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.46210996
58GATA3_27048872_Chip-Seq_THYMUS_Human1.45745553
59SPI1_23127762_ChIP-Seq_K562_Human1.42585337
60GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42278601
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39783686
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36264888
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32913852
64* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32388833
65* GATA2_21666600_ChIP-Seq_HMVEC_Human1.28385940
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27615315
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27434175
68* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25400981
69GATA1_19941826_ChIP-Seq_K562_Human1.25170505
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.25015468
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23741482
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23741482
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.23679627
74CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22524876
75PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22158698
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20272465
77EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19924243
78TAF15_26573619_Chip-Seq_HEK293_Human1.18723736
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18569264
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17797795
81VDR_22108803_ChIP-Seq_LS180_Human1.17335636
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17300285
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14321385
84TFEB_21752829_ChIP-Seq_HELA_Human1.13777967
85IRF1_19129219_ChIP-ChIP_H3396_Human1.13241523
86* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12657666
87CLOCK_20551151_ChIP-Seq_293T_Human1.12323793
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12070505
89IGF1R_20145208_ChIP-Seq_DFB_Human1.12018252
90ELK1_19687146_ChIP-ChIP_HELA_Human1.11778431
91MAF_26560356_Chip-Seq_TH2_Human1.10926216
92* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10778064
93GATA3_26560356_Chip-Seq_TH2_Human1.10042183
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05949866
95* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04307025
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04173071
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02943782
98* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02816545
99* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01699975
100GATA2_19941826_ChIP-Seq_K562_Human1.01380697
101SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01093949
102CDX2_22108803_ChIP-Seq_LS180_Human1.00638167
103VDR_24787735_ChIP-Seq_THP-1_Human1.00598755
104LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00369300
105GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00086653
106SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99735095
107* CRX_20693478_ChIP-Seq_RETINA_Mouse0.99717480
108* FLI1_21867929_ChIP-Seq_TH2_Mouse0.99667643
109SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98505275
110SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96901544
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96901544
112GATA3_26560356_Chip-Seq_TH1_Human0.96072119
113FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95357582
114KDM2B_26808549_Chip-Seq_DND41_Human0.94217723
115NCOR1_26117541_ChIP-Seq_K562_Human0.94013765
116* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92212393
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92095203
118SMRT_27268052_Chip-Seq_Bcells_Human0.91501870
119FOXM1_23109430_ChIP-Seq_U2OS_Human0.91328316
120FUS_26573619_Chip-Seq_HEK293_Human0.91283211
121FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90639631
122FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89828961
123PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89564860
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88897668
125SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88475970
126PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87090574
127SALL4_22934838_ChIP-ChIP_CD34+_Human0.86987000
128OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86873485
129EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85946967
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85753632
131GATA1_19941827_ChIP-Seq_MEL_Mouse0.85737295
132PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85233483
133ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85064670
134PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84691429
135* ER_23166858_ChIP-Seq_MCF-7_Human0.84104846
136HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83626451
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.82015111
138VDR_23849224_ChIP-Seq_CD4+_Human0.80987409
139RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80825172
140RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.78972481
141KDM2B_26808549_Chip-Seq_SUP-B15_Human0.78166520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.55369438
2MP0003436_decreased_susceptibility_to3.04491110
3MP0005671_abnormal_response_to2.84322742
4MP0003303_peritoneal_inflammation2.78278233
5MP0009785_altered_susceptibility_to2.74627702
6MP0005000_abnormal_immune_tolerance2.68342428
7MP0000685_abnormal_immune_system2.68240176
8MP0009697_abnormal_copulation2.57200457
9MP0003300_gastrointestinal_ulcer2.56334699
10MP0002148_abnormal_hypersensitivity_rea2.54433026
11MP0003724_increased_susceptibility_to2.50829432
12MP0005387_immune_system_phenotype2.49198506
13MP0001790_abnormal_immune_system2.49198506
14MP0001800_abnormal_humoral_immune2.41549929
15MP0005025_abnormal_response_to2.37295994
16MP0002419_abnormal_innate_immunity2.37251250
17MP0002452_abnormal_antigen_presenting2.36282033
18MP0006082_CNS_inflammation2.24769269
19MP0002723_abnormal_immune_serum2.24613916
20MP0002420_abnormal_adaptive_immunity2.18123565
21MP0001819_abnormal_immune_cell2.17427446
22MP0003763_abnormal_thymus_physiology2.15957508
23MP0002166_altered_tumor_susceptibility2.06564478
24MP0004510_myositis1.99454340
25MP0002405_respiratory_system_inflammati1.97988220
26* MP0005464_abnormal_platelet_physiology1.97024708
27MP0002877_abnormal_melanocyte_morpholog1.95875804
28MP0002398_abnormal_bone_marrow1.88245550
29MP0002006_tumorigenesis1.86539899
30MP0005058_abnormal_lysosome_morphology1.85087361
31MP0009333_abnormal_splenocyte_physiolog1.83427863
32MP0010155_abnormal_intestine_physiology1.81809955
33MP0005084_abnormal_gallbladder_morpholo1.81132562
34MP0004947_skin_inflammation1.80842545
35MP0003806_abnormal_nucleotide_metabolis1.79405761
36MP0001533_abnormal_skeleton_physiology1.78285041
37MP0008004_abnormal_stomach_pH1.76326038
38MP0000716_abnormal_immune_system1.74266112
39MP0001845_abnormal_inflammatory_respons1.72964535
40MP0001853_heart_inflammation1.69872877
41MP0006054_spinal_hemorrhage1.68023739
42MP0003448_altered_tumor_morphology1.66223750
43MP0010352_gastrointestinal_tract_polyps1.65871819
44MP0004808_abnormal_hematopoietic_stem1.63855369
45MP0000858_altered_metastatic_potential1.56073458
46MP0005397_hematopoietic_system_phenotyp1.56011537
47MP0001545_abnormal_hematopoietic_system1.56011537
48MP0000465_gastrointestinal_hemorrhage1.55999874
49MP0000689_abnormal_spleen_morphology1.55275569
50MP0000015_abnormal_ear_pigmentation1.54606440
51MP0002396_abnormal_hematopoietic_system1.52982409
52MP0003172_abnormal_lysosome_physiology1.52895953
53MP0002722_abnormal_immune_system1.49421577
54MP0009384_cardiac_valve_regurgitation1.49035313
55MP0002429_abnormal_blood_cell1.48385628
56MP0002933_joint_inflammation1.46780694
57MP0001873_stomach_inflammation1.43048881
58MP0002138_abnormal_hepatobiliary_system1.40731168
59MP0004084_abnormal_cardiac_muscle1.33875672
60MP0003566_abnormal_cell_adhesion1.32226277
61MP0005076_abnormal_cell_differentiation1.32218804
62MP0009278_abnormal_bone_marrow1.30066982
63MP0008469_abnormal_protein_level1.29623495
64MP0000013_abnormal_adipose_tissue1.28121412
65MP0005310_abnormal_salivary_gland1.27383668
66MP0000490_abnormal_crypts_of1.26692499
67MP0003183_abnormal_peptide_metabolism1.26335482
68MP0000343_altered_response_to1.26063293
69MP0002998_abnormal_bone_remodeling1.25785170
70MP0000703_abnormal_thymus_morphology1.21535653
71MP0003866_abnormal_defecation1.20484153
72MP0003656_abnormal_erythrocyte_physiolo1.17224128
73MP0010307_abnormal_tumor_latency1.14151633
74MP0003828_pulmonary_edema1.10426206
75MP0005075_abnormal_melanosome_morpholog1.00912020
76MP0005167_abnormal_blood-brain_barrier1.00567226
77MP0003279_aneurysm1.00002140
78MP0005023_abnormal_wound_healing0.99922750
79MP0005390_skeleton_phenotype0.97599363
80MP0009764_decreased_sensitivity_to0.96583213
81MP0003191_abnormal_cellular_cholesterol0.95882276
82MP0004484_altered_response_of0.94561042
83MP0001851_eye_inflammation0.93749653
84MP0003795_abnormal_bone_structure0.92999752
85MP0002132_abnormal_respiratory_system0.92307981
86MP0002693_abnormal_pancreas_physiology0.89610376
87MP0005174_abnormal_tail_pigmentation0.88066378
88MP0004782_abnormal_surfactant_physiolog0.87334062
89MP0008438_abnormal_cutaneous_collagen0.87207589
90MP0003453_abnormal_keratinocyte_physiol0.86491734
91MP0000230_abnormal_systemic_arterial0.86377830
92MP0005595_abnormal_vascular_smooth0.83127258
93MP0000249_abnormal_blood_vessel0.82444335
94MP0002019_abnormal_tumor_incidence0.81358154
95MP0003075_altered_response_to0.81329439
96MP0001879_abnormal_lymphatic_vessel0.80794150
97MP0000767_abnormal_smooth_muscle0.80215544
98MP0004883_abnormal_blood_vessel0.79330783
99MP0008007_abnormal_cellular_replicative0.78507394
100MP0005164_abnormal_response_to0.78489153
101MP0005165_increased_susceptibility_to0.77666301
102MP0003091_abnormal_cell_migration0.77085197
103MP0003705_abnormal_hypodermis_morpholog0.75783472
104MP0005166_decreased_susceptibility_to0.75331207
105MP0001663_abnormal_digestive_system0.73736566
106MP0009763_increased_sensitivity_to0.72252283
107MP0002136_abnormal_kidney_physiology0.70792841
108MP0001958_emphysema0.70513927
109MP0005379_endocrine/exocrine_gland_phen0.70485937
110MP0001727_abnormal_embryo_implantation0.68982985
111MP0001915_intracranial_hemorrhage0.68337749
112MP0003943_abnormal_hepatobiliary_system0.68183092
113MP0004036_abnormal_muscle_relaxation0.68057134
114MP0002928_abnormal_bile_duct0.66754423
115MP0002009_preneoplasia0.64562697
116MP0000569_abnormal_digit_pigmentation0.63073073
117MP0001881_abnormal_mammary_gland0.62417550
118MP0001188_hyperpigmentation0.61376150
119MP0001191_abnormal_skin_condition0.61284027
120MP0010234_abnormal_vibrissa_follicle0.59335963
121MP0010386_abnormal_urinary_bladder0.58779567
122MP0002095_abnormal_skin_pigmentation0.58201404
123MP0003045_fibrosis0.58063839
124MP0005535_abnormal_body_temperature0.57920636
125MP0000371_diluted_coat_color0.57747796
126MP0003195_calcinosis0.56396855
127MP0003252_abnormal_bile_duct0.54802462
128MP0009765_abnormal_xenobiotic_induced0.54649742
129MP0001348_abnormal_lacrimal_gland0.53745238

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.09056405
2Recurrent abscess formation (HP:0002722)5.04983782
3Recurrent bacterial skin infections (HP:0005406)4.47969058
4Myositis (HP:0100614)4.39365113
5Orchitis (HP:0100796)3.89623183
6Autoimmune hemolytic anemia (HP:0001890)3.84206619
7Elevated erythrocyte sedimentation rate (HP:0003565)3.75560432
8Retrobulbar optic neuritis (HP:0100654)3.64456855
9Optic neuritis (HP:0100653)3.64456855
10Recurrent fungal infections (HP:0002841)3.41707508
11Acanthocytosis (HP:0001927)3.38726353
12Aortic aneurysm (HP:0004942)3.36882616
13Abnormality of macrophages (HP:0004311)3.33253564
14Hematochezia (HP:0002573)3.32798924
15Recurrent gram-negative bacterial infections (HP:0005420)3.31948982
16Recurrent viral infections (HP:0004429)3.23291525
17Vacuolated lymphocytes (HP:0001922)3.19465932
18Interstitial pulmonary disease (HP:0006530)3.13356562
19Chronic otitis media (HP:0000389)3.10186243
20Mediastinal lymphadenopathy (HP:0100721)3.09481643
21Acute myeloid leukemia (HP:0004808)3.01248419
22Arterial thrombosis (HP:0004420)2.99219461
23IgM deficiency (HP:0002850)2.95948747
24Recurrent skin infections (HP:0001581)2.94899123
25Systemic lupus erythematosus (HP:0002725)2.93999803
26Abnormality of B cell number (HP:0010975)2.89011451
27Increased cerebral lipofuscin (HP:0011813)2.88666571
28Vasculitis (HP:0002633)2.86968193
29Spontaneous hematomas (HP:0007420)2.86634498
30Abnormal delayed hypersensitivity skin test (HP:0002963)2.85490255
31Autoimmune thrombocytopenia (HP:0001973)2.85170672
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.84338950
33Petechiae (HP:0000967)2.82827676
34Conjunctival telangiectasia (HP:0000524)2.82320108
35Pulmonary infiltrates (HP:0002113)2.79792665
36Obstructive lung disease (HP:0006536)2.78634223
37Chronic obstructive pulmonary disease (HP:0006510)2.78634223
38Increased neuronal autofluorescent lipopigment (HP:0002074)2.77647075
39Abnormality of T cell number (HP:0011839)2.77141049
40Pustule (HP:0200039)2.75645138
41Prolonged bleeding time (HP:0003010)2.75240755
42Dysostosis multiplex (HP:0000943)2.73999420
43Abnormality of the vasculature of the conjunctiva (HP:0008054)2.73209786
44Abnormality of T cell physiology (HP:0011840)2.72945101
45T lymphocytopenia (HP:0005403)2.72856407
46Abnormality of T cells (HP:0002843)2.69126922
47Periodontitis (HP:0000704)2.68046194
48Stomatitis (HP:0010280)2.66249974
49Meningitis (HP:0001287)2.64629166
50Gingivitis (HP:0000230)2.64067424
51Cellulitis (HP:0100658)2.63327687
52Thrombocytosis (HP:0001894)2.63066987
53Acute hepatic failure (HP:0006554)2.62069925
54Urinary glycosaminoglycan excretion (HP:0003541)2.55837943
55Mucopolysacchariduria (HP:0008155)2.55837943
56Recurrent bronchitis (HP:0002837)2.55155540
57Recurrent cutaneous fungal infections (HP:0011370)2.52605676
58Chronic mucocutaneous candidiasis (HP:0002728)2.52605676
59Epistaxis (HP:0000421)2.50654706
60Hemoptysis (HP:0002105)2.49466322
61Abnormality of eosinophils (HP:0001879)2.48682613
62Basal ganglia calcification (HP:0002135)2.48262609
63Inflammation of the large intestine (HP:0002037)2.44877425
64Gingival bleeding (HP:0000225)2.44306538
65Abnormal platelet volume (HP:0011876)2.44021037
66Poikilocytosis (HP:0004447)2.41713746
67Leukocytosis (HP:0001974)2.40109187
68Keratoconjunctivitis sicca (HP:0001097)2.39978987
69Gastrointestinal infarctions (HP:0005244)2.39679912
70Gastrointestinal inflammation (HP:0004386)2.36692655
71Abnormality of the nasal mucosa (HP:0000433)2.36489886
72Nasal polyposis (HP:0100582)2.34011178
73Osteolytic defects of the phalanges of the hand (HP:0009771)2.30570856
74Osteolytic defects of the hand bones (HP:0009699)2.30570856
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29351182
76Abnormality of polysaccharide metabolism (HP:0011012)2.29351182
77Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29351182
78Bruising susceptibility (HP:0000978)2.26606947
79Lymphoma (HP:0002665)2.25878909
80Abnormality of iron homeostasis (HP:0011031)2.24333095
81Dyschromatopsia (HP:0007641)2.21845164
82Eosinophilia (HP:0001880)2.18708410
83Submucous cleft hard palate (HP:0000176)2.17335780
84Menorrhagia (HP:0000132)2.17156979
85Abnormal platelet function (HP:0011869)2.16537124
86Impaired platelet aggregation (HP:0003540)2.16537124
87Increased mean platelet volume (HP:0011877)2.16156908
88Decreased central vision (HP:0007663)2.15469504
89Abnormality of transition element cation homeostasis (HP:0011030)2.15309912
90Keratoconjunctivitis (HP:0001096)2.14946967
91B lymphocytopenia (HP:0010976)2.14107062
92Purpura (HP:0000979)2.13818001
93Chest pain (HP:0100749)2.13386978
94Severe combined immunodeficiency (HP:0004430)2.13295796
95Increased IgM level (HP:0003496)2.13153093
96Disinhibition (HP:0000734)2.12100666
97Myocardial infarction (HP:0001658)2.09873190
98Encephalitis (HP:0002383)2.08630831
99Lymphopenia (HP:0001888)2.08473121
100Albinism (HP:0001022)2.08302194
101Abnormality of the prostate (HP:0008775)2.08019832
102Osteomyelitis (HP:0002754)2.07473749
103Abnormality of cells of the lymphoid lineage (HP:0012140)2.05443936
104Colitis (HP:0002583)2.03405027
105Spondylolisthesis (HP:0003302)2.02398333
106Hypergammaglobulinemia (HP:0010702)2.02086801
107IgA deficiency (HP:0002720)2.01961284
108Vertebral compression fractures (HP:0002953)2.01727764
109Abnormality of liposaccharide metabolism (HP:0010968)1.99521314
110Abnormality of glycosphingolipid metabolism (HP:0004343)1.99521314
111Abnormality of glycolipid metabolism (HP:0010969)1.99521314
112Panhypogammaglobulinemia (HP:0003139)1.98925077
113Thrombophlebitis (HP:0004418)1.98442102
114Renal cortical cysts (HP:0000803)1.97591653
115Increased IgE level (HP:0003212)1.96539864
116Granulocytopenia (HP:0001913)1.95843195
117Thyroiditis (HP:0100646)1.95048326
118Pulmonary embolism (HP:0002204)1.94642426
119Skin ulcer (HP:0200042)1.93892963
120Glomerulonephritis (HP:0000099)1.93830095
121Microcytic anemia (HP:0001935)1.93217331
122Episodic fever (HP:0001954)1.92018319
123Fatigue (HP:0012378)1.90884686
124Glomerulopathy (HP:0100820)1.89051857
125Hypoproteinemia (HP:0003075)1.88883049
126Joint swelling (HP:0001386)1.88826967
127Chronic diarrhea (HP:0002028)1.88669715
128IgG deficiency (HP:0004315)1.85425350
129Gangrene (HP:0100758)1.83738059
130Capillary hemangiomas (HP:0005306)1.80377355
131Polycythemia (HP:0001901)1.79815953
132Urticaria (HP:0001025)1.79370256
133Amaurosis fugax (HP:0100576)1.79153279
134Combined immunodeficiency (HP:0005387)1.78696451
135Aplastic anemia (HP:0001915)1.77727385
136Increased serum ferritin (HP:0003281)1.76946137
137Myelodysplasia (HP:0002863)1.75080940
138Amyloidosis (HP:0011034)1.74276798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.37314924
2MAP4K13.34957713
3MAP3K143.05091102
4JAK33.00028382
5TYK22.50503239
6TBK12.43431563
7TGFBR22.41666310
8ZAP702.33299528
9BLK2.32158676
10IRAK42.26309166
11IRAK32.09619885
12STK101.99006954
13IKBKE1.97531435
14ERN11.96478152
15BMPR21.89457742
16BTK1.74202082
17IKBKB1.72788792
18TEC1.72670404
19RPS6KA41.71836873
20TRIM281.69751519
21ITK1.67379600
22MST41.61291074
23JAK11.60751091
24EPHB11.57405368
25EPHA31.57136447
26TAOK31.55255603
27KIT1.52936976
28CSK1.52715939
29NME21.46328183
30FGFR31.45349113
31NLK1.43426593
32TRIB31.42161969
33PIM21.41764918
34CHUK1.41111137
35LRRK21.40121323
36MAP3K31.37870435
37PIK3CG1.34292994
38KDR1.32629910
39BMPR1B1.32568217
40NEK91.32135983
41PKN21.30633055
42MAP2K31.30315365
43PIM11.21860975
44LCK1.21696585
45FGFR41.21401962
46SYK1.17602036
47MKNK11.12058611
48HCK1.10472581
49TGFBR11.09704603
50PLK41.09505400
51FGR1.08246468
52PTK2B1.07398022
53PRKCQ1.07184090
54FLT31.06204975
55RIPK41.04992175
56CSF1R1.04313082
57PTK61.03540097
58JAK21.01996929
59MYLK1.01569563
60RIPK11.01408585
61ADRBK21.01360147
62ACVR1B1.00004216
63SCYL20.99539832
64MARK30.92144324
65LYN0.88156043
66PINK10.88018480
67PAK40.86799484
68MAP3K50.81795502
69BCR0.81756274
70MAP3K120.81412628
71EIF2AK10.81116799
72MAPK70.79659452
73MAP3K100.79390020
74PASK0.78588931
75HIPK20.77041116
76IRAK10.73693548
77NEK20.71184464
78TRPM70.70247257
79CDK60.68641206
80PLK20.68396772
81FRK0.66208237
82CLK10.65688496
83RAF10.64356104
84BRSK20.63430525
85TTN0.62747122
86GRK60.62066750
87EEF2K0.61494578
88MAPKAPK20.61405375
89CSNK1G30.60539635
90MAP3K130.60527530
91STK30.60242315
92STK240.60102963
93MAP3K20.58495209
94MAP3K60.58443835
95TESK10.56809879
96PRKG20.56042568
97MATK0.53485747
98CDK80.52469471
99PDGFRB0.51973844
100EIF2AK30.51246184
101SIK30.49337920
102MKNK20.48755666
103ERBB30.47516843
104ABL10.47418010
105CDK40.46564042
106MAP2K70.46196550
107CSNK1G20.45818952
108ADRBK10.44869940
109MAP3K80.44831022
110MAP3K10.44699583
111MAP4K20.44241305
112CDK90.44019699
113FES0.43111784
114STK390.42830232
115EGFR0.42535045
116FYN0.39976614
117TIE10.39898406
118CAMKK20.39492860
119YES10.39026469
120NUAK10.38243079
121IGF1R0.38191981
122MAPK150.37546299
123TESK20.37066268
124MAPK110.37051125
125WNK40.36347890
126BMX0.36178211
127EIF2AK20.35473979
128PRKCD0.34794128
129STK40.34365304
130GRK70.33239811
131PDGFRA0.32928574
132RPS6KA50.32700969
133RPS6KB20.32562722
134RPS6KA60.32458169
135KSR10.32273530
136GRK10.31663748

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.82478644
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.34104658
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.28277489
4Graft-versus-host disease_Homo sapiens_hsa053322.20844320
5Antigen processing and presentation_Homo sapiens_hsa046122.18377778
6Measles_Homo sapiens_hsa051622.13881766
7Osteoclast differentiation_Homo sapiens_hsa043802.13062693
8Allograft rejection_Homo sapiens_hsa053302.06197120
9Legionellosis_Homo sapiens_hsa051342.05624264
10Staphylococcus aureus infection_Homo sapiens_hsa051502.01389484
11Primary immunodeficiency_Homo sapiens_hsa053401.99850857
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94300258
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.90650064
14Hematopoietic cell lineage_Homo sapiens_hsa046401.85485884
15Pertussis_Homo sapiens_hsa051331.76302478
16B cell receptor signaling pathway_Homo sapiens_hsa046621.74710420
17Toxoplasmosis_Homo sapiens_hsa051451.73266135
18Malaria_Homo sapiens_hsa051441.72482001
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68914049
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.68304410
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68037256
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67510805
23Herpes simplex infection_Homo sapiens_hsa051681.56565746
24TNF signaling pathway_Homo sapiens_hsa046681.54797601
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.54002018
26Tuberculosis_Homo sapiens_hsa051521.53046627
27T cell receptor signaling pathway_Homo sapiens_hsa046601.49153492
28Shigellosis_Homo sapiens_hsa051311.48678188
29Other glycan degradation_Homo sapiens_hsa005111.46773786
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.46734361
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46124651
32Influenza A_Homo sapiens_hsa051641.44580083
33Asthma_Homo sapiens_hsa053101.40860731
34Lysosome_Homo sapiens_hsa041421.40416421
35Apoptosis_Homo sapiens_hsa042101.36703082
36Hepatitis B_Homo sapiens_hsa051611.33878769
37Type I diabetes mellitus_Homo sapiens_hsa049401.33210954
38Viral myocarditis_Homo sapiens_hsa054161.30474815
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25631750
40Dorso-ventral axis formation_Homo sapiens_hsa043201.24960565
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22530918
42Autoimmune thyroid disease_Homo sapiens_hsa053201.22524427
43Acute myeloid leukemia_Homo sapiens_hsa052211.21595991
44Chronic myeloid leukemia_Homo sapiens_hsa052201.21299865
45Salmonella infection_Homo sapiens_hsa051321.19512294
46* Leukocyte transendothelial migration_Homo sapiens_hsa046701.19028791
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18269199
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17294556
49* Chemokine signaling pathway_Homo sapiens_hsa040621.16603612
50Rheumatoid arthritis_Homo sapiens_hsa053231.13892020
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13508253
52Long-term depression_Homo sapiens_hsa047301.11651297
53Pancreatic cancer_Homo sapiens_hsa052121.10157561
54Renin secretion_Homo sapiens_hsa049241.09905389
55Protein export_Homo sapiens_hsa030601.09713939
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09207040
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04414166
58Vascular smooth muscle contraction_Homo sapiens_hsa042701.04138389
59Small cell lung cancer_Homo sapiens_hsa052221.01508258
60* Platelet activation_Homo sapiens_hsa046111.01381881
61Phagosome_Homo sapiens_hsa041450.99005780
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98739596
63Prolactin signaling pathway_Homo sapiens_hsa049170.91619944
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90757694
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89773541
66Viral carcinogenesis_Homo sapiens_hsa052030.88338995
67Hepatitis C_Homo sapiens_hsa051600.87086339
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86671942
69Serotonergic synapse_Homo sapiens_hsa047260.85639700
70HTLV-I infection_Homo sapiens_hsa051660.84551894
71Epstein-Barr virus infection_Homo sapiens_hsa051690.83473347
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82690639
73Amoebiasis_Homo sapiens_hsa051460.81249983
74p53 signaling pathway_Homo sapiens_hsa041150.79933395
75Arachidonic acid metabolism_Homo sapiens_hsa005900.77750140
76Gap junction_Homo sapiens_hsa045400.77313941
77Salivary secretion_Homo sapiens_hsa049700.70847714
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67635586
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.67241625
80N-Glycan biosynthesis_Homo sapiens_hsa005100.60505383
81* Neurotrophin signaling pathway_Homo sapiens_hsa047220.57803103
82Adherens junction_Homo sapiens_hsa045200.57268917
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56842788
84Prostate cancer_Homo sapiens_hsa052150.56030772
85Caffeine metabolism_Homo sapiens_hsa002320.55421473
86Proteoglycans in cancer_Homo sapiens_hsa052050.55407719
87African trypanosomiasis_Homo sapiens_hsa051430.54863376
88* Focal adhesion_Homo sapiens_hsa045100.54184607
89Colorectal cancer_Homo sapiens_hsa052100.52958864
90MicroRNAs in cancer_Homo sapiens_hsa052060.52717466
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52460950
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52323160
93VEGF signaling pathway_Homo sapiens_hsa043700.52314598
94DNA replication_Homo sapiens_hsa030300.51280009
95Thyroid cancer_Homo sapiens_hsa052160.50572830
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50073727
97FoxO signaling pathway_Homo sapiens_hsa040680.49337419
98ECM-receptor interaction_Homo sapiens_hsa045120.48021241
99Sulfur metabolism_Homo sapiens_hsa009200.47450197
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47025552
101Endocytosis_Homo sapiens_hsa041440.46604268
102Insulin resistance_Homo sapiens_hsa049310.44513916
103Olfactory transduction_Homo sapiens_hsa047400.44197649
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43614385
105HIF-1 signaling pathway_Homo sapiens_hsa040660.42666690
106Notch signaling pathway_Homo sapiens_hsa043300.42609202
107Taste transduction_Homo sapiens_hsa047420.42393049
108* Ras signaling pathway_Homo sapiens_hsa040140.41008279
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40727148
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40348864
111Non-small cell lung cancer_Homo sapiens_hsa052230.40021909
112* MAPK signaling pathway_Homo sapiens_hsa040100.39631358
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.39109831
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38593633
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.35977472
116Cell cycle_Homo sapiens_hsa041100.35796893
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35140564
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34514966
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.33758341
120Linoleic acid metabolism_Homo sapiens_hsa005910.33501926
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33244867
122Inositol phosphate metabolism_Homo sapiens_hsa005620.33221005
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33006556
124Prion diseases_Homo sapiens_hsa050200.32931503
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32413785
126Ovarian steroidogenesis_Homo sapiens_hsa049130.32098077
127Fatty acid elongation_Homo sapiens_hsa000620.29463483
128Ether lipid metabolism_Homo sapiens_hsa005650.28972561
129Oxytocin signaling pathway_Homo sapiens_hsa049210.28471626
130Pathways in cancer_Homo sapiens_hsa052000.27762705
131Melanoma_Homo sapiens_hsa052180.27155886

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