RAP1GAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.50578429
2negative regulation of cell killing (GO:0031342)5.50578429
3synaptic vesicle maturation (GO:0016188)5.22475918
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.21809856
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.19808508
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.83659142
7locomotory exploration behavior (GO:0035641)4.48910989
8regulation of synaptic vesicle exocytosis (GO:2000300)4.44943806
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.35046029
10glutamate secretion (GO:0014047)4.33999784
11COPI coating of Golgi vesicle (GO:0048205)4.31321123
12Golgi transport vesicle coating (GO:0048200)4.31321123
13synaptic vesicle exocytosis (GO:0016079)4.23702696
14positive regulation by symbiont of host defense response (GO:0052509)4.06292139
15modulation by symbiont of host defense response (GO:0052031)4.06292139
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.06292139
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.06292139
18positive regulation by organism of defense response of other organism involved in symbiotic interact4.06292139
19modulation by symbiont of host immune response (GO:0052553)4.06292139
20detection of calcium ion (GO:0005513)4.03247661
21negative regulation of erythrocyte differentiation (GO:0045647)4.01893049
22positive regulation of gamma-delta T cell activation (GO:0046645)3.95033985
23activation of protein kinase A activity (GO:0034199)3.93465749
24regulation of synaptic vesicle transport (GO:1902803)3.92349492
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.89119177
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.87167161
27antigen processing and presentation of endogenous antigen (GO:0019883)3.80660103
28macrophage activation involved in immune response (GO:0002281)3.79345784
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.78059240
30regulation of B cell receptor signaling pathway (GO:0050855)3.66954626
31membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.66647709
32neutrophil activation involved in immune response (GO:0002283)3.64943809
33leukocyte aggregation (GO:0070486)3.59234191
34regulation of regulated secretory pathway (GO:1903305)3.56988720
35signal complex assembly (GO:0007172)3.56878891
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.56463776
37insulin secretion (GO:0030073)3.53202679
38chemosensory behavior (GO:0007635)3.51889639
39neurotransmitter secretion (GO:0007269)3.48978506
40detection of other organism (GO:0098543)3.48611469
41vocalization behavior (GO:0071625)3.47244139
42cell communication by electrical coupling (GO:0010644)3.46089277
43antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.40512228
44cerebellar Purkinje cell layer development (GO:0021680)3.39956295
45proline transport (GO:0015824)3.34985574
46negative regulation of lymphocyte mediated immunity (GO:0002707)3.34680756
47regulation of leukocyte degranulation (GO:0043300)3.33138596
48detection of bacterium (GO:0016045)3.32884788
49regulation of ARF protein signal transduction (GO:0032012)3.32762455
50membrane repolarization during action potential (GO:0086011)3.27987955
51regulation of glutamate receptor signaling pathway (GO:1900449)3.25861278
52regulation of amyloid precursor protein catabolic process (GO:1902991)3.25842905
53regulation of beta-amyloid formation (GO:1902003)3.25730811
54neuronal action potential propagation (GO:0019227)3.25471824
55regulation of neuronal synaptic plasticity (GO:0048168)3.25439427
56regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.24460024
57regulation of myeloid leukocyte mediated immunity (GO:0002886)3.22857551
58layer formation in cerebral cortex (GO:0021819)3.20876251
59retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.20271689
60negative regulation of leukocyte mediated immunity (GO:0002704)3.19943183
61negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.18589381
62exploration behavior (GO:0035640)3.15420271
63sodium ion export (GO:0071436)3.13304651
64response to peptidoglycan (GO:0032494)3.12433779
65cellular potassium ion homeostasis (GO:0030007)3.12282892
66regulation of synapse structural plasticity (GO:0051823)3.10899788
67regulation of calcium ion-dependent exocytosis (GO:0017158)3.09227346
68protein targeting to Golgi (GO:0000042)3.07006385
69vesicle transport along microtubule (GO:0047496)3.06153804
70regulation of gamma-delta T cell activation (GO:0046643)3.03745756
71* positive regulation of Rap GTPase activity (GO:0032854)3.03687874
72relaxation of cardiac muscle (GO:0055119)3.03513896
73regulation of ARF GTPase activity (GO:0032312)3.02724316
74cellular extravasation (GO:0045123)3.02278040
75response to interleukin-15 (GO:0070672)3.02159813
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.01710408
77L-amino acid import (GO:0043092)3.01485511
78regulation of long-term neuronal synaptic plasticity (GO:0048169)3.00565886
79potassium ion import (GO:0010107)3.00067718
80membrane repolarization (GO:0086009)2.99345710
81cerebellar granule cell differentiation (GO:0021707)2.99178779
82positive regulation of regulated secretory pathway (GO:1903307)2.98809272
83maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.97906092
84activated T cell proliferation (GO:0050798)2.96951030
85dendritic spine morphogenesis (GO:0060997)2.96700491
86regulation of mast cell degranulation (GO:0043304)2.96052774
87G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.94711633
88positive regulation of synaptic transmission, GABAergic (GO:0032230)2.93655571
89macrophage activation (GO:0042116)2.93004999
90regulation of cellular amide metabolic process (GO:0034248)2.92733552
91glycine transport (GO:0015816)2.91859016
92membrane depolarization during action potential (GO:0086010)2.90799862
93regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.90756417
94leukocyte migration involved in inflammatory response (GO:0002523)2.89694730
95positive regulation of synapse maturation (GO:0090129)2.89455719
96cell communication involved in cardiac conduction (GO:0086065)2.88271890
97positive regulation of cellular amide metabolic process (GO:0034250)2.88178225
98response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.86297607
99response to host immune response (GO:0052572)2.86297607
100establishment of protein localization to Golgi (GO:0072600)2.84898114
101suckling behavior (GO:0001967)2.84835433
102respiratory burst (GO:0045730)2.84336344
103neutrophil activation (GO:0042119)2.84070551
104positive regulation of potassium ion transport (GO:0043268)2.83235494
105negative regulation of T cell mediated immunity (GO:0002710)2.82581565
106positive regulation of exocytosis (GO:0045921)2.81721762
107antigen processing and presentation via MHC class Ib (GO:0002475)2.79854950
108innervation (GO:0060384)2.79564503
109protein localization to synapse (GO:0035418)2.79134346
110regulation of gamma-delta T cell differentiation (GO:0045586)2.78933509
111regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.78527698
112long-term memory (GO:0007616)2.78298524
113regulation of insulin secretion (GO:0050796)2.78024295
114neuron cell-cell adhesion (GO:0007158)2.77895027
115synaptic transmission, glutamatergic (GO:0035249)2.77691339
116detection of external biotic stimulus (GO:0098581)2.77619305
117cellular response to glucagon stimulus (GO:0071377)2.77584029
118protein maturation by protein folding (GO:0022417)2.76387431
119myeloid cell activation involved in immune response (GO:0002275)2.76277142
120positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.75894535
121regulation of vesicle fusion (GO:0031338)2.75222384
122protein retention in ER lumen (GO:0006621)2.74695507
123cytoskeletal anchoring at plasma membrane (GO:0007016)2.74146926
124microglial cell activation (GO:0001774)2.73921250
125peptide hormone secretion (GO:0030072)2.73774651
126activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.73509044
127endocrine pancreas development (GO:0031018)2.72531911
128neurotransmitter transport (GO:0006836)2.72050076
129cerebellar Purkinje cell differentiation (GO:0021702)2.72018305
130regulation of neurotransmitter secretion (GO:0046928)2.71826246
131regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.71564589
132positive regulation of membrane potential (GO:0045838)2.71433794
133regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.69834894
134ionotropic glutamate receptor signaling pathway (GO:0035235)2.69061075
135regulation of membrane repolarization (GO:0060306)2.68395202
136regulation of exocytosis (GO:0017157)2.68024305
137positive regulation of neurotransmitter transport (GO:0051590)2.67760705
138negative regulation of type 2 immune response (GO:0002829)2.67717142
139response to ischemia (GO:0002931)2.67714817
140peptide hormone processing (GO:0016486)2.67498291
141signal release (GO:0023061)2.67471655
142response to host (GO:0075136)2.67378403
143response to host defenses (GO:0052200)2.67378403
144response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.67378403
145peptide secretion (GO:0002790)2.66817751
146positive regulation of vesicle fusion (GO:0031340)2.65163285
147regulation of mast cell activation involved in immune response (GO:0033006)2.63969686
148neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.63497328
149positive thymic T cell selection (GO:0045059)2.63323216
150retrograde transport, vesicle recycling within Golgi (GO:0000301)2.62005043
151nerve growth factor signaling pathway (GO:0038180)2.61868459
152negative regulation of glycoprotein biosynthetic process (GO:0010561)2.60578358
153positive regulation of potassium ion transmembrane transport (GO:1901381)2.60067655
154neuromuscular process controlling posture (GO:0050884)2.59379592
155response to muramyl dipeptide (GO:0032495)2.59279626
156cellular response to interleukin-15 (GO:0071350)2.59013786
157positive regulation of neurotransmitter secretion (GO:0001956)2.58399807
158gamma-aminobutyric acid transport (GO:0015812)2.58335643
159regulation of synaptic plasticity (GO:0048167)2.58238301
160organelle transport along microtubule (GO:0072384)2.57719201
161calcium ion-dependent exocytosis (GO:0017156)2.57670869
162growth hormone secretion (GO:0030252)2.57009403
163negative regulation of hormone biosynthetic process (GO:0032353)2.56240217
164negative regulation of hormone metabolic process (GO:0032351)2.56240217
165detection of molecule of bacterial origin (GO:0032490)2.55923226
166regulation of T-helper 2 cell differentiation (GO:0045628)2.55868417
167plasma membrane repair (GO:0001778)2.55756112
168positive regulation of insulin secretion (GO:0032024)2.55574608
169negative regulation of phagocytosis (GO:0050765)2.55480519
170granulocyte activation (GO:0036230)2.55135880
171actin filament polymerization (GO:0030041)2.49545918
172production of molecular mediator involved in inflammatory response (GO:0002532)2.48852153
173* regulation of Rap GTPase activity (GO:0032317)2.48494297
174negative thymic T cell selection (GO:0045060)2.47076829
175B cell receptor signaling pathway (GO:0050853)2.46370692
176positive regulation of mast cell activation (GO:0033005)2.45315912
177negative regulation of toll-like receptor signaling pathway (GO:0034122)2.43957765
178negative regulation of dendrite morphogenesis (GO:0050774)2.43724530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.26307315
2* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.87111576
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.86728320
4DROSHA_22980978_ChIP-Seq_HELA_Human2.70664214
5REST_21632747_ChIP-Seq_MESCs_Mouse2.66128088
6* TCF7_22412390_ChIP-Seq_EML_Mouse2.58925620
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.57740696
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55864101
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55333153
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.53681868
11* KDM2B_26808549_Chip-Seq_DND41_Human2.49072112
12MYC_22102868_ChIP-Seq_BL_Human2.45107813
13GBX2_23144817_ChIP-Seq_PC3_Human2.43663239
14VDR_21846776_ChIP-Seq_THP-1_Human2.42891832
15* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.38046026
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36411466
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.34385773
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.31819533
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.25568930
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25496248
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.24213630
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.22270307
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20204701
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18388341
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18388341
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16140134
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15774267
28IRF8_22096565_ChIP-ChIP_GC-B_Human2.06767783
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04386439
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01936814
31* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00317169
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96962028
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94556073
34* SPI1_23127762_ChIP-Seq_K562_Human1.94456537
35* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.93725848
36VDR_24763502_ChIP-Seq_THP-1_Human1.93487800
37* EZH2_27294783_Chip-Seq_ESCs_Mouse1.93320385
38* EZH2_27304074_Chip-Seq_ESCs_Mouse1.89011840
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88600483
40* RNF2_27304074_Chip-Seq_ESCs_Mouse1.84534196
41SCL_19346495_ChIP-Seq_HPC-7_Human1.83235017
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.82425334
43* KDM2B_26808549_Chip-Seq_JURKAT_Human1.81305498
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.80856548
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78176817
46MAF_26560356_Chip-Seq_TH1_Human1.74262726
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.72886516
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69491342
49* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68847576
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68789640
51* UTX_26944678_Chip-Seq_JUKART_Human1.67213928
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.64313345
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.63951494
54RUNX_20019798_ChIP-Seq_JUKART_Human1.62808979
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62564432
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59222622
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.58991991
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58988172
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56516975
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55371494
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55183736
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53329238
63* RACK7_27058665_Chip-Seq_MCF-7_Human1.52151508
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.45119334
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.44887906
66* SMAD4_21799915_ChIP-Seq_A2780_Human1.44568062
67ZNF274_21170338_ChIP-Seq_K562_Hela1.44396450
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44386464
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43451105
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.41639629
71FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41267578
72* SMC4_20622854_ChIP-Seq_HELA_Human1.41201711
73KDM2B_26808549_Chip-Seq_K562_Human1.40722009
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38678159
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37548906
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.36677258
77GATA1_22025678_ChIP-Seq_K562_Human1.36536411
78MAF_26560356_Chip-Seq_TH2_Human1.35113007
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34767967
80WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34288085
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.33362431
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32999153
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32303898
84AR_19668381_ChIP-Seq_PC3_Human1.31606236
85P68_20966046_ChIP-Seq_HELA_Human1.30986438
86EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26544518
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26386597
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26277121
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25989989
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25321910
91STAT3_23295773_ChIP-Seq_U87_Human1.24699101
92* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24608990
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24223330
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23212645
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20219540
96SPI1_23547873_ChIP-Seq_NB4_Human1.19253498
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16498134
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15947760
99ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15421625
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15366948
101* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14933673
102YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13008925
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12590483
104PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11879218
105MYB_26560356_Chip-Seq_TH2_Human1.11843098
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10587651
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.10369880
108EP300_21415370_ChIP-Seq_HL-1_Mouse1.09991179
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09902537
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09479335
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08866316
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.08676955
113* OCT4_19829295_ChIP-Seq_ESCs_Human1.08676461
114CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08584261
115* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08362467
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08115070
117AHR_22903824_ChIP-Seq_MCF-7_Human1.08055753
118MYB_26560356_Chip-Seq_TH1_Human1.07873954
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07048045
120* SA1_27219007_Chip-Seq_ERYTHROID_Human1.06510339
121BCOR_27268052_Chip-Seq_Bcells_Human1.05441434
122CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04355727
123OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04238097
124GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03508671
125ARNT_22903824_ChIP-Seq_MCF-7_Human1.03426819
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02847657
127SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02766143
128IGF1R_20145208_ChIP-Seq_DFB_Human1.02316162
129TCF4_23295773_ChIP-Seq_U87_Human1.01684892
130ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01517309
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01175160
132CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00984718
133SMAD3_21741376_ChIP-Seq_ESCs_Human0.98635698
134FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97915190
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.97599390
136* TET1_21490601_ChIP-Seq_MESCs_Mouse0.96978076
137TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96778161
138RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96491891
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.96242327
140* GATA3_27048872_Chip-Seq_THYMUS_Human0.95378982
141CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95369300
142P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94552743
143PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94047447
144SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93830566
145SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93313685
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93091152
147CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93067744
148* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92674245
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92652720
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92110414
151CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91882803
152* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91849123
153SMAD_19615063_ChIP-ChIP_OVARY_Human0.90883784
154* AR_25329375_ChIP-Seq_VCAP_Human0.90518295
155* CTCF_27219007_Chip-Seq_Bcells_Human0.90040625
156ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87821256
157ESR2_21235772_ChIP-Seq_MCF-7_Human0.87656418
158BCAT_22108803_ChIP-Seq_LS180_Human0.85957465
159RING1B_27294783_Chip-Seq_NPCs_Mouse0.85252002
160SMAD3_21741376_ChIP-Seq_HESCs_Human0.85185824
161AR_21572438_ChIP-Seq_LNCaP_Human0.84346902
162CREB1_26743006_Chip-Seq_LNCaP_Human0.83773762
163NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83711453
164LXR_22292898_ChIP-Seq_THP-1_Human0.81759013
165GATA1_19941826_ChIP-Seq_K562_Human0.80773152
166LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80295761
167MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80151301
168RXR_22108803_ChIP-Seq_LS180_Human0.80090130
169P300_19829295_ChIP-Seq_ESCs_Human0.79721085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.83495102
2MP0004270_analgesia3.72565254
3MP0002909_abnormal_adrenal_gland3.67730283
4MP0009780_abnormal_chondrocyte_physiolo3.44084276
5MP0003283_abnormal_digestive_organ3.24912640
6MP0003635_abnormal_synaptic_transmissio3.16307224
7MP0002837_dystrophic_cardiac_calcinosis2.90367250
8MP0000013_abnormal_adipose_tissue2.84530913
9MP0003724_increased_susceptibility_to2.70482557
10MP0003436_decreased_susceptibility_to2.70001100
11MP0003880_abnormal_central_pattern2.42450302
12MP0003690_abnormal_glial_cell2.41400517
13MP0002063_abnormal_learning/memory/cond2.40382816
14MP0002877_abnormal_melanocyte_morpholog2.27088584
15MP0002734_abnormal_mechanical_nocicepti2.26590339
16MP0003303_peritoneal_inflammation2.26536404
17MP0009745_abnormal_behavioral_response2.25773194
18MP0004043_abnormal_pH_regulation2.23573165
19MP0002693_abnormal_pancreas_physiology2.21888630
20MP0003123_paternal_imprinting2.18757028
21MP0002064_seizures2.17715439
22MP0002572_abnormal_emotion/affect_behav1.99129617
23MP0001944_abnormal_pancreas_morphology1.94565857
24MP0008961_abnormal_basal_metabolism1.93417664
25MP0008260_abnormal_autophagy1.92382813
26MP0010386_abnormal_urinary_bladder1.90163183
27MP0002272_abnormal_nervous_system1.89946941
28MP0001968_abnormal_touch/_nociception1.89385169
29MP0009046_muscle_twitch1.86804417
30MP0002733_abnormal_thermal_nociception1.81193611
31MP0003763_abnormal_thymus_physiology1.79398571
32MP0004858_abnormal_nervous_system1.77660530
33MP0005409_darkened_coat_color1.77081302
34MP0002822_catalepsy1.76056093
35MP0002419_abnormal_innate_immunity1.75381483
36MP0005645_abnormal_hypothalamus_physiol1.74452544
37MP0005423_abnormal_somatic_nervous1.70498097
38MP0006082_CNS_inflammation1.68905278
39MP0001970_abnormal_pain_threshold1.68081137
40MP0001835_abnormal_antigen_presentation1.68022866
41MP0002396_abnormal_hematopoietic_system1.60093907
42MP0001486_abnormal_startle_reflex1.59183757
43MP0000003_abnormal_adipose_tissue1.57918341
44MP0001501_abnormal_sleep_pattern1.55515029
45MP0003075_altered_response_to1.55147735
46MP0003122_maternal_imprinting1.54884061
47MP0004145_abnormal_muscle_electrophysio1.52991319
48MP0003879_abnormal_hair_cell1.52830279
49MP0003866_abnormal_defecation1.52327884
50MP0008569_lethality_at_weaning1.51350069
51MP0005025_abnormal_response_to1.51307834
52MP0003183_abnormal_peptide_metabolism1.50855956
53MP0003787_abnormal_imprinting1.50775753
54MP0005646_abnormal_pituitary_gland1.50456078
55MP0005000_abnormal_immune_tolerance1.49276193
56MP0004811_abnormal_neuron_physiology1.47825164
57MP0004215_abnormal_myocardial_fiber1.47329357
58MP0003329_amyloid_beta_deposits1.45784573
59MP0003195_calcinosis1.45269711
60MP0002735_abnormal_chemical_nociception1.44134613
61MP0005464_abnormal_platelet_physiology1.43313828
62MP0002420_abnormal_adaptive_immunity1.42607656
63MP0001819_abnormal_immune_cell1.40676751
64MP0000678_abnormal_parathyroid_gland1.40426390
65MP0005386_behavior/neurological_phenoty1.39239817
66MP0004924_abnormal_behavior1.39239817
67MP0002078_abnormal_glucose_homeostasis1.38501282
68MP0009278_abnormal_bone_marrow1.37439399
69MP0001800_abnormal_humoral_immune1.36959339
70MP0002234_abnormal_pharynx_morphology1.35950725
71MP0002557_abnormal_social/conspecific_i1.35648571
72MP0003191_abnormal_cellular_cholesterol1.34516008
73MP0002067_abnormal_sensory_capabilities1.34175763
74MP0000751_myopathy1.34047121
75MP0003172_abnormal_lysosome_physiology1.32943312
76MP0001440_abnormal_grooming_behavior1.31990030
77MP0005451_abnormal_body_composition1.31622395
78MP0002723_abnormal_immune_serum1.30046409
79MP0000920_abnormal_myelination1.29110753
80MP0000955_abnormal_spinal_cord1.29104444
81MP0003633_abnormal_nervous_system1.26798747
82MP0002009_preneoplasia1.24192209
83MP0002184_abnormal_innervation1.23787095
84MP0002736_abnormal_nociception_after1.23227539
85MP0004085_abnormal_heartbeat1.20804896
86MP0005379_endocrine/exocrine_gland_phen1.20108340
87MP0005535_abnormal_body_temperature1.20007007
88MP0004947_skin_inflammation1.19691024
89MP0002398_abnormal_bone_marrow1.19328746
90MP0004036_abnormal_muscle_relaxation1.18670874
91MP0001851_eye_inflammation1.16192511
92MP0005671_abnormal_response_to1.14797605
93MP0000703_abnormal_thymus_morphology1.13888214
94MP0004084_abnormal_cardiac_muscle1.13447076
95MP0003045_fibrosis1.13433967
96MP0002452_abnormal_antigen_presenting1.13098301
97MP0010234_abnormal_vibrissa_follicle1.11080306
98MP0001765_abnormal_ion_homeostasis1.10816462
99MP0001790_abnormal_immune_system1.09117757
100MP0005387_immune_system_phenotype1.09117757
101MP0001502_abnormal_circadian_rhythm1.08671306
102MP0008874_decreased_physiological_sensi1.08558232
103MP0001533_abnormal_skeleton_physiology1.08366749
104MP0002066_abnormal_motor_capabilities/c1.07103412
105MP0000685_abnormal_immune_system1.06510394
106MP0008004_abnormal_stomach_pH1.05463746
107MP0004381_abnormal_hair_follicle1.05394803
108MP0000716_abnormal_immune_system1.05238829
109MP0006072_abnormal_retinal_apoptosis1.03886050
110MP0000604_amyloidosis1.03236557
111MP0002882_abnormal_neuron_morphology1.02591864
112MP0002405_respiratory_system_inflammati0.98832100
113MP0001984_abnormal_olfaction0.96125911
114MP0002896_abnormal_bone_mineralization0.95582335
115MP0005058_abnormal_lysosome_morphology0.95533839
116MP0002069_abnormal_eating/drinking_beha0.95260509
117MP0004510_myositis0.94898309
118MP0004130_abnormal_muscle_cell0.94271861
119MP0005187_abnormal_penis_morphology0.93993877
120MP0003953_abnormal_hormone_level0.93856486
121MP0006276_abnormal_autonomic_nervous0.92934999
122MP0005220_abnormal_exocrine_pancreas0.92190600
123MP0005166_decreased_susceptibility_to0.91952564
124MP0004885_abnormal_endolymph0.90066382
125MP0008877_abnormal_DNA_methylation0.89942822
126MP0001348_abnormal_lacrimal_gland0.89184836
127MP0001299_abnormal_eye_distance/0.88688821
128MP0002722_abnormal_immune_system0.88534996
129MP0000778_abnormal_nervous_system0.87402196
130MP0002166_altered_tumor_susceptibility0.85642030
131MP0003868_abnormal_feces_composition0.85436001
132MP0000569_abnormal_digit_pigmentation0.84673651
133MP0003631_nervous_system_phenotype0.84408164
134MP0002638_abnormal_pupillary_reflex0.84226637
135MP0005448_abnormal_energy_balance0.82112062
136MP0003137_abnormal_impulse_conducting0.82043330
137MP0002229_neurodegeneration0.81901467
138MP0001664_abnormal_digestion0.80953888
139MP0001986_abnormal_taste_sensitivity0.80869301
140MP0002429_abnormal_blood_cell0.80845227
141MP0003828_pulmonary_edema0.80378693
142MP0000689_abnormal_spleen_morphology0.80231796
143MP0005310_abnormal_salivary_gland0.79862765
144MP0000631_abnormal_neuroendocrine_gland0.79293467
145MP0004264_abnormal_extraembryonic_tissu0.78570579
146MP0010155_abnormal_intestine_physiology0.78538133
147MP0003300_gastrointestinal_ulcer0.78321503
148MP0001845_abnormal_inflammatory_respons0.76462880
149MP0002132_abnormal_respiratory_system0.76331209
150MP0000747_muscle_weakness0.76235438
151MP0002972_abnormal_cardiac_muscle0.76161971
152MP0003634_abnormal_glial_cell0.75732209
153MP0005375_adipose_tissue_phenotype0.75518523
154MP0004233_abnormal_muscle_weight0.74186826
155MP0002928_abnormal_bile_duct0.73147842
156MP0002152_abnormal_brain_morphology0.72728477

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.35152312
2Eczematoid dermatitis (HP:0000976)4.82801949
3Hyperinsulinemic hypoglycemia (HP:0000825)4.63580064
4Visual hallucinations (HP:0002367)4.62545582
5Focal motor seizures (HP:0011153)4.27101722
6Papilledema (HP:0001085)4.01496601
7Recurrent bacterial skin infections (HP:0005406)3.85066616
8Myokymia (HP:0002411)3.80295525
9Recurrent abscess formation (HP:0002722)3.76233284
10Obstructive sleep apnea (HP:0002870)3.59629125
11Focal seizures (HP:0007359)3.54532933
12Hypoglycemic seizures (HP:0002173)3.50356045
13Myositis (HP:0100614)3.41210994
14Abnormality of macrophages (HP:0004311)3.40355781
15Epileptic encephalopathy (HP:0200134)3.34874766
16Insulin-resistant diabetes mellitus (HP:0000831)3.30961356
17Large for gestational age (HP:0001520)3.30387331
18Pancreatic islet-cell hyperplasia (HP:0004510)3.28759860
19Ventricular fibrillation (HP:0001663)3.28372595
20Abnormality of calcium-phosphate metabolism (HP:0100530)3.21299708
21Bundle branch block (HP:0011710)3.20549430
22Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.19366559
23Abnormality of the pancreatic islet cells (HP:0006476)3.18225519
24Abnormality of endocrine pancreas physiology (HP:0012093)3.18225519
25Ketoacidosis (HP:0001993)3.16186202
26Orchitis (HP:0100796)3.14075327
27EEG with generalized epileptiform discharges (HP:0011198)3.11476180
28Atonic seizures (HP:0010819)3.10574137
29Episodic fever (HP:0001954)3.08545165
30Agitation (HP:0000713)3.07861437
31Hypsarrhythmia (HP:0002521)3.07095308
32Epileptiform EEG discharges (HP:0011182)3.06315927
33Symptomatic seizures (HP:0011145)3.04038879
34Slow saccadic eye movements (HP:0000514)3.01227218
35Hyperglycemia (HP:0003074)3.00748960
36Abnormality of binocular vision (HP:0011514)2.96303519
37Diplopia (HP:0000651)2.96303519
38Action tremor (HP:0002345)2.95437889
39Retrobulbar optic neuritis (HP:0100654)2.88336307
40Optic neuritis (HP:0100653)2.88336307
41Depression (HP:0000716)2.87823837
42Pheochromocytoma (HP:0002666)2.86640215
43Stomatitis (HP:0010280)2.85761725
44Decreased circulating renin level (HP:0003351)2.83584536
45Absence seizures (HP:0002121)2.81498103
46Recurrent gram-negative bacterial infections (HP:0005420)2.75370696
47Prolonged bleeding time (HP:0003010)2.70519095
48Hypoglycemic coma (HP:0001325)2.69013002
49Poor eye contact (HP:0000817)2.68870487
50Increased IgE level (HP:0003212)2.65855681
51Generalized tonic-clonic seizures (HP:0002069)2.64971008
52Supranuclear gaze palsy (HP:0000605)2.61781185
53Gingivitis (HP:0000230)2.59645698
54Neuronal loss in central nervous system (HP:0002529)2.59300062
55Prolonged QT interval (HP:0001657)2.56415687
56Tetraplegia (HP:0002445)2.55577544
57Hypercortisolism (HP:0001578)2.53996044
58Ankle clonus (HP:0011448)2.50689660
59Progressive cerebellar ataxia (HP:0002073)2.50347153
60Anxiety (HP:0000739)2.48747921
61Recurrent fungal infections (HP:0002841)2.47602160
62Abnormal social behavior (HP:0012433)2.46879490
63Impaired social interactions (HP:0000735)2.46879490
64Febrile seizures (HP:0002373)2.46521560
65Annular pancreas (HP:0001734)2.46432769
66Late onset (HP:0003584)2.45554719
67Dialeptic seizures (HP:0011146)2.45431258
68Gastrointestinal infarctions (HP:0005244)2.44308782
69Truncal ataxia (HP:0002078)2.38572918
70Recurrent skin infections (HP:0001581)2.38136148
71Sudden death (HP:0001699)2.38070802
72Syncope (HP:0001279)2.38039504
73Impaired smooth pursuit (HP:0007772)2.36765074
74Elevated erythrocyte sedimentation rate (HP:0003565)2.35299153
75Chronic obstructive pulmonary disease (HP:0006510)2.31409356
76Obstructive lung disease (HP:0006536)2.31409356
77Cellulitis (HP:0100658)2.29934933
78Neuroendocrine neoplasm (HP:0100634)2.29778427
79Macroorchidism (HP:0000053)2.27341447
80Hypokalemia (HP:0002900)2.24262265
81Gastrointestinal inflammation (HP:0004386)2.24253440
82Failure to thrive in infancy (HP:0001531)2.22887319
83Neurofibrillary tangles (HP:0002185)2.20956920
84Abnormal EKG (HP:0003115)2.20156980
85Increased circulating renin level (HP:0000848)2.19599439
86Inflammation of the large intestine (HP:0002037)2.16405742
87Hyperparathyroidism (HP:0000843)2.14503022
88Menstrual irregularities (HP:0000858)2.13834361
89Intention tremor (HP:0002080)2.13295188
90Urinary glycosaminoglycan excretion (HP:0003541)2.13220290
91Mucopolysacchariduria (HP:0008155)2.13220290
92Meningitis (HP:0001287)2.11484393
93Abnormality of renin-angiotensin system (HP:0000847)2.10432894
94Amyloidosis (HP:0011034)2.09610381
95Abnormality of saccadic eye movements (HP:0000570)2.09359731
96Impaired vibration sensation in the lower limbs (HP:0002166)2.08792645
97Postural instability (HP:0002172)2.07526193
98Resting tremor (HP:0002322)2.06971989
99Unilateral renal agenesis (HP:0000122)2.06297350
100Gingival bleeding (HP:0000225)2.04705057
101Increased CSF protein (HP:0002922)2.03927837
102Abnormal pancreas size (HP:0012094)2.02920245
103Hypochromic microcytic anemia (HP:0004840)2.02811046
104Neonatal hypoglycemia (HP:0001998)2.01961916
105Neoplasm of the heart (HP:0100544)2.01246578
106Dysmetric saccades (HP:0000641)2.00650773
107Spontaneous hematomas (HP:0007420)2.00327786
108Retinal atrophy (HP:0001105)1.99956839
109Insomnia (HP:0100785)1.99236219
110Postural tremor (HP:0002174)1.98502811
111Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97366723
112Abnormality of polysaccharide metabolism (HP:0011012)1.97366723
113Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97366723
114Urinary bladder sphincter dysfunction (HP:0002839)1.96289696
115Mediastinal lymphadenopathy (HP:0100721)1.96140346
116Chest pain (HP:0100749)1.95894299
117Pustule (HP:0200039)1.95527630
118Rigidity (HP:0002063)1.95204466
119Dysostosis multiplex (HP:0000943)1.93096987
120Testicular neoplasm (HP:0010788)1.91984904
121Difficulty running (HP:0009046)1.91699744
122Megalencephaly (HP:0001355)1.91544516
123Keratoconjunctivitis sicca (HP:0001097)1.91516501
124Dysdiadochokinesis (HP:0002075)1.91447317
125Subacute progressive viral hepatitis (HP:0006572)1.90612311
126Abnormality of potassium homeostasis (HP:0011042)1.90159919
127Dysmetria (HP:0001310)1.89381777
128Amblyopia (HP:0000646)1.88682259
129Encephalitis (HP:0002383)1.87662398
130Cerebral inclusion bodies (HP:0100314)1.87164113
131Urticaria (HP:0001025)1.86982523
132Genetic anticipation (HP:0003743)1.86913496
133Abnormal delayed hypersensitivity skin test (HP:0002963)1.86648367
134Abnormality of ocular smooth pursuit (HP:0000617)1.83378744
135Apathy (HP:0000741)1.83317834
136Gaze-evoked nystagmus (HP:0000640)1.82781792
137Epistaxis (HP:0000421)1.81258054
138Broad face (HP:0000283)1.81239938
139Adrenal overactivity (HP:0002717)1.79263255
140Recurrent cutaneous fungal infections (HP:0011370)1.78753823
141Chronic mucocutaneous candidiasis (HP:0002728)1.78753823
142Growth hormone excess (HP:0000845)1.78340925
143Hypochromic anemia (HP:0001931)1.77919080
144Clonus (HP:0002169)1.77323679
145Excessive salivation (HP:0003781)1.76855838
146Drooling (HP:0002307)1.76855838
147Lower limb asymmetry (HP:0100559)1.75763368
148Hemiplegia (HP:0002301)1.75758292
149Keratoconjunctivitis (HP:0001096)1.75694176
150Polygenic inheritance (HP:0010982)1.75016243
151Mildly elevated creatine phosphokinase (HP:0008180)1.74569045
152Rapidly progressive (HP:0003678)1.74454720
153Ankyloglossia (HP:0010296)1.74360737
154Abnormal eating behavior (HP:0100738)1.74263512
155Arterial thrombosis (HP:0004420)1.73825906
156Congenital glaucoma (HP:0001087)1.72854600
157Spastic gait (HP:0002064)1.71048577
158Heart block (HP:0012722)1.70543164
159Abnormality of the lower motor neuron (HP:0002366)1.70438912
160Athetosis (HP:0002305)1.68971517
161Spinal canal stenosis (HP:0003416)1.67539286
162Exercise-induced myalgia (HP:0003738)1.66997415
163Bradykinesia (HP:0002067)1.66556158
164Prominent metopic ridge (HP:0005487)1.65435136

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.83868433
2INSRR3.35620138
3PRKD33.26752315
4MAP3K93.17488700
5MAP3K22.64754148
6DAPK22.41435694
7NTRK12.33664766
8MAP3K42.32406026
9EPHA42.28365975
10MARK12.17944611
11TNK22.15756039
12KSR22.15119932
13MAP4K12.12803989
14CAMKK12.12232825
15MAP2K31.99848361
16EPHB11.97429220
17PAK61.91338427
18TAOK31.85445676
19CAMKK21.85167512
20MAP3K131.84313469
21MINK11.82654761
22UHMK11.82623645
23TRIB31.71191985
24IRAK41.69528731
25HIPK21.67464938
26MAP2K71.61278888
27FRK1.58904279
28MAP3K11.58296398
29PRKCH1.57083915
30BLK1.56488786
31GRK61.55339939
32PASK1.52703294
33ERN11.51921485
34NTRK21.49529518
35ZAP701.45309495
36CSK1.41881666
37RIPK11.39689777
38MAP2K41.39144674
39SCYL21.37395884
40RET1.34380449
41CDK121.33168533
42CDK51.32835162
43MAP3K111.30454802
44WNK41.29396295
45IRAK21.28356087
46STK381.28176607
47MAPK151.27851564
48CDC42BPA1.26314116
49TYK21.22922467
50PAK31.22390408
51LMTK21.19651472
52PDGFRA1.16206878
53RIPK41.14135735
54WNK31.14061509
55GRK51.13275101
56FGR1.12973655
57PHKG11.12783246
58PHKG21.12783246
59SMG11.11347623
60DAPK11.09588038
61TAOK11.05117917
62CDK191.03540086
63HCK0.99316083
64MAP3K30.98848519
65MAPK120.97162010
66WNK10.95405760
67ALK0.95231399
68STK110.90562148
69BTK0.90267968
70KSR10.89650731
71FGFR30.88194426
72YES10.87635904
73SYK0.86262774
74SGK2230.86175081
75SGK4940.86175081
76ICK0.85356040
77SGK30.85223797
78SIK30.83371668
79PDPK10.81231695
80MAP2K60.79907022
81PDK10.77493537
82PRKCG0.75014081
83PRKD20.74809303
84FGFR40.74625728
85PINK10.74110034
86SGK20.73984228
87FER0.73684728
88CAMK1G0.71436869
89MARK20.71118739
90CAMK2D0.70967749
91PKN20.69249979
92SIK10.69042155
93CAMK10.68959136
94CAMK2A0.68953973
95DMPK0.68728740
96PTK20.67334438
97ITK0.66639929
98ARAF0.65940694
99CAMK1D0.64811967
100JAK30.63072081
101MAPK130.63042800
102RPS6KA20.61819233
103CAMK2B0.61271206
104SGK10.60465982
105NEK60.59183866
106PTK2B0.58851847
107LCK0.58443150
108FES0.58074418
109MAP2K10.58059378
110FGFR20.57770854
111SIK20.57649082
112TYRO30.57160879
113PNCK0.57027963
114EEF2K0.57025076
115PRKD10.54358805
116PRKCE0.53148038
117PRKG20.52629957
118PRKAA10.52479290
119RPS6KA30.52175063
120TAOK20.51608184
121PLK20.51067030
122JAK20.49826797
123PTK60.49739704
124BRSK10.49323035
125BMX0.46216195
126TTN0.45876056
127CAMK40.45497975
128PRKCZ0.44903257
129RAF10.43358945
130LYN0.42383760
131JAK10.42068241
132CSF1R0.41954029
133PRPF4B0.40424625
134DAPK30.40124973
135CDK140.39733895
136MAP3K70.39587222
137DYRK1A0.38073691
138MAPK100.37979763
139CDK150.37372040
140CDK180.36242215
141PDGFRB0.34935320
142PRKACG0.34396091
143MAP3K120.34009019
144BMPR20.33499447
145FYN0.33333541
146TNIK0.31924343

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.35367381
2Insulin secretion_Homo sapiens_hsa049113.05800732
3Synaptic vesicle cycle_Homo sapiens_hsa047212.47220285
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29428727
5Type II diabetes mellitus_Homo sapiens_hsa049302.28963407
6Circadian entrainment_Homo sapiens_hsa047132.21036638
7Long-term potentiation_Homo sapiens_hsa047202.18457008
8Amphetamine addiction_Homo sapiens_hsa050312.14286364
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.09283586
10GABAergic synapse_Homo sapiens_hsa047272.04418574
11Olfactory transduction_Homo sapiens_hsa047402.03631332
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.91607336
13Dopaminergic synapse_Homo sapiens_hsa047281.88560464
14Morphine addiction_Homo sapiens_hsa050321.87572060
15Glutamatergic synapse_Homo sapiens_hsa047241.86853941
16Nicotine addiction_Homo sapiens_hsa050331.82808191
17Cholinergic synapse_Homo sapiens_hsa047251.82774306
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81463746
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.77686375
20Pancreatic secretion_Homo sapiens_hsa049721.73261613
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.72944942
22Cocaine addiction_Homo sapiens_hsa050301.69988110
23Osteoclast differentiation_Homo sapiens_hsa043801.69500806
24Gastric acid secretion_Homo sapiens_hsa049711.66385146
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64597352
26Taste transduction_Homo sapiens_hsa047421.61532620
27Salivary secretion_Homo sapiens_hsa049701.59868966
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.59408772
29B cell receptor signaling pathway_Homo sapiens_hsa046621.58567299
30Renin secretion_Homo sapiens_hsa049241.48453606
31Carbohydrate digestion and absorption_Homo sapiens_hsa049731.48417828
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42987519
33Estrogen signaling pathway_Homo sapiens_hsa049151.37943246
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37030334
35Oxytocin signaling pathway_Homo sapiens_hsa049211.32815449
36T cell receptor signaling pathway_Homo sapiens_hsa046601.32226225
37Type I diabetes mellitus_Homo sapiens_hsa049401.31560934
38Serotonergic synapse_Homo sapiens_hsa047261.30974803
39GnRH signaling pathway_Homo sapiens_hsa049121.30910770
40Long-term depression_Homo sapiens_hsa047301.27654402
41Acute myeloid leukemia_Homo sapiens_hsa052211.25332333
42Leishmaniasis_Homo sapiens_hsa051401.24920925
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.20737063
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16416006
45Vibrio cholerae infection_Homo sapiens_hsa051101.16365177
46Calcium signaling pathway_Homo sapiens_hsa040201.14857351
47cAMP signaling pathway_Homo sapiens_hsa040241.13498227
48Tuberculosis_Homo sapiens_hsa051521.12660107
49Gap junction_Homo sapiens_hsa045401.12231828
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.11851870
51Thyroid hormone synthesis_Homo sapiens_hsa049181.06254431
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.05407130
53Glucagon signaling pathway_Homo sapiens_hsa049221.04598591
54Dorso-ventral axis formation_Homo sapiens_hsa043201.03638831
55Dilated cardiomyopathy_Homo sapiens_hsa054141.03233114
56Glioma_Homo sapiens_hsa052141.02255336
57Platelet activation_Homo sapiens_hsa046111.01968770
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00836570
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.98980460
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98933705
61Chronic myeloid leukemia_Homo sapiens_hsa052200.97024055
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96934233
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96639982
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94699190
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91148420
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91086468
67Melanogenesis_Homo sapiens_hsa049160.91059036
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90867709
69Collecting duct acid secretion_Homo sapiens_hsa049660.90629887
70Other glycan degradation_Homo sapiens_hsa005110.89912046
71mTOR signaling pathway_Homo sapiens_hsa041500.87890757
72Nitrogen metabolism_Homo sapiens_hsa009100.82848855
73Cardiac muscle contraction_Homo sapiens_hsa042600.82042377
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.80736686
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79034790
76Insulin signaling pathway_Homo sapiens_hsa049100.78709274
77Pancreatic cancer_Homo sapiens_hsa052120.77179606
78ErbB signaling pathway_Homo sapiens_hsa040120.76225080
79Regulation of autophagy_Homo sapiens_hsa041400.75408877
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75117159
81FoxO signaling pathway_Homo sapiens_hsa040680.74431987
82Circadian rhythm_Homo sapiens_hsa047100.73818940
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71814732
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70806513
85Insulin resistance_Homo sapiens_hsa049310.70713687
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69992529
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.67935510
88Prolactin signaling pathway_Homo sapiens_hsa049170.65563617
89Inositol phosphate metabolism_Homo sapiens_hsa005620.64655201
90Notch signaling pathway_Homo sapiens_hsa043300.63994411
91VEGF signaling pathway_Homo sapiens_hsa043700.63128795
92Hepatitis C_Homo sapiens_hsa051600.62686675
93Endometrial cancer_Homo sapiens_hsa052130.61868813
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61258863
95Prion diseases_Homo sapiens_hsa050200.61114687
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60917949
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.60197447
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.59933769
99African trypanosomiasis_Homo sapiens_hsa051430.58284214
100Protein export_Homo sapiens_hsa030600.57650519
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.56763516
102MAPK signaling pathway_Homo sapiens_hsa040100.56558932
103Measles_Homo sapiens_hsa051620.56185987
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56044193
105Legionellosis_Homo sapiens_hsa051340.55908417
106Colorectal cancer_Homo sapiens_hsa052100.55832042
107Toxoplasmosis_Homo sapiens_hsa051450.55650774
108Lysosome_Homo sapiens_hsa041420.51563587
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50651061
110Choline metabolism in cancer_Homo sapiens_hsa052310.50180325
111Sulfur metabolism_Homo sapiens_hsa009200.50003102
112Renal cell carcinoma_Homo sapiens_hsa052110.49704048
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48875590
114Alcoholism_Homo sapiens_hsa050340.48871376
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47437209
116Endocytosis_Homo sapiens_hsa041440.47046970
117Oocyte meiosis_Homo sapiens_hsa041140.46317328
118Protein digestion and absorption_Homo sapiens_hsa049740.45721446
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44399576
120Non-small cell lung cancer_Homo sapiens_hsa052230.43640039
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43134743
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.41063387
123Ras signaling pathway_Homo sapiens_hsa040140.40986619
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40948076
125Bile secretion_Homo sapiens_hsa049760.40819828
126Axon guidance_Homo sapiens_hsa043600.39944277
127Rap1 signaling pathway_Homo sapiens_hsa040150.38886418
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.38023608
129AMPK signaling pathway_Homo sapiens_hsa041520.36557791
130Ovarian steroidogenesis_Homo sapiens_hsa049130.34539743
131N-Glycan biosynthesis_Homo sapiens_hsa005100.33449166
132Chemokine signaling pathway_Homo sapiens_hsa040620.32334109

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