RAPGEF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)5.11383512
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.18046919
3positive regulation by organism of defense response of other organism involved in symbiotic interact4.18046919
4modulation by symbiont of host immune response (GO:0052553)4.18046919
5positive regulation by symbiont of host defense response (GO:0052509)4.18046919
6modulation by symbiont of host defense response (GO:0052031)4.18046919
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.18046919
8positive regulation of histone deacetylation (GO:0031065)4.10095422
9positive thymic T cell selection (GO:0045059)4.06113343
10negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.99542498
11response to peptidoglycan (GO:0032494)3.96896795
12sarcomere organization (GO:0045214)3.93680223
13negative regulation of interleukin-12 production (GO:0032695)3.82668562
14macrophage activation involved in immune response (GO:0002281)3.81688912
15cardiac myofibril assembly (GO:0055003)3.78576178
16regulation of gamma-delta T cell differentiation (GO:0045586)3.75083661
17negative regulation of cell size (GO:0045792)3.74579651
18germinal center formation (GO:0002467)3.72475310
19response to muramyl dipeptide (GO:0032495)3.63793516
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.61409994
21positive regulation of gamma-delta T cell activation (GO:0046645)3.58334223
22negative regulation of potassium ion transmembrane transport (GO:1901380)3.48985406
23protein localization to endosome (GO:0036010)3.45204502
24detection of other organism (GO:0098543)3.44978171
25NIK/NF-kappaB signaling (GO:0038061)3.42347519
26regulation of B cell receptor signaling pathway (GO:0050855)3.41455147
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.38936943
28cellular extravasation (GO:0045123)3.36785928
29adherens junction assembly (GO:0034333)3.36108494
30B cell receptor signaling pathway (GO:0050853)3.32337766
31cytoskeletal anchoring at plasma membrane (GO:0007016)3.29085017
32positive T cell selection (GO:0043368)3.28909019
33detection of bacterium (GO:0016045)3.28860410
34actin-myosin filament sliding (GO:0033275)3.28711251
35muscle filament sliding (GO:0030049)3.28711251
36myofibril assembly (GO:0030239)3.28558306
37thymic T cell selection (GO:0045061)3.26679814
38cytoplasmic mRNA processing body assembly (GO:0033962)3.25892221
39regulation of gamma-delta T cell activation (GO:0046643)3.25718457
40morphogenesis of an endothelium (GO:0003159)3.24782633
41endothelial tube morphogenesis (GO:0061154)3.24782633
42pre-miRNA processing (GO:0031054)3.24591036
43focal adhesion assembly (GO:0048041)3.22902787
44cell-substrate adherens junction assembly (GO:0007045)3.22902787
45mannose metabolic process (GO:0006013)3.20249652
46NLS-bearing protein import into nucleus (GO:0006607)3.17050068
47lipopolysaccharide-mediated signaling pathway (GO:0031663)3.16858635
48neutrophil activation involved in immune response (GO:0002283)3.13244205
49regulation of dendritic cell antigen processing and presentation (GO:0002604)3.12546214
50regulation of interleukin-12 biosynthetic process (GO:0045075)3.12089975
51peptidyl-lysine dimethylation (GO:0018027)3.08840666
52positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.06244791
53regulation of interferon-beta biosynthetic process (GO:0045357)3.04976981
54immunoglobulin mediated immune response (GO:0016064)3.03213288
55positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.99235462
56detection of molecule of bacterial origin (GO:0032490)2.97835524
57detection of external biotic stimulus (GO:0098581)2.97780715
58regulation of p38MAPK cascade (GO:1900744)2.96741125
59response to laminar fluid shear stress (GO:0034616)2.95797055
60negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.94207545
61negative regulation of cell killing (GO:0031342)2.94207545
62regulation of leukocyte degranulation (GO:0043300)2.93292199
63myeloid dendritic cell differentiation (GO:0043011)2.90874376
64stress fiber assembly (GO:0043149)2.90776060
65cardiac muscle contraction (GO:0060048)2.89687951
66regulation of T-helper 2 cell differentiation (GO:0045628)2.88731264
67leukocyte aggregation (GO:0070486)2.88168301
68negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.88155760
69regulation of mast cell degranulation (GO:0043304)2.88063570
70cell-substrate junction assembly (GO:0007044)2.87520773
71regulation of ARF GTPase activity (GO:0032312)2.86912432
72positive regulation of myotube differentiation (GO:0010831)2.86658831
73carnitine shuttle (GO:0006853)2.86507335
74antigen processing and presentation of endogenous antigen (GO:0019883)2.86054642
75T cell selection (GO:0045058)2.85613360
76regulation of NFAT protein import into nucleus (GO:0051532)2.85132949
77antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.84999734
78antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.84999734
79T cell migration (GO:0072678)2.82978689
80negative regulation of toll-like receptor signaling pathway (GO:0034122)2.82229915
81regulation of T cell tolerance induction (GO:0002664)2.80529378
82insulin-like growth factor receptor signaling pathway (GO:0048009)2.80228170
83negative regulation of cardiac muscle tissue growth (GO:0055022)2.79291558
84negative regulation of heart growth (GO:0061117)2.79291558
85positive regulation of cellular amide metabolic process (GO:0034250)2.77155504
86regulation of fatty acid beta-oxidation (GO:0031998)2.77011939
87interferon-gamma-mediated signaling pathway (GO:0060333)2.76701259
88tolerance induction (GO:0002507)2.75567444
89negative regulation of erythrocyte differentiation (GO:0045647)2.75394814
90positive regulation of protein deacetylation (GO:0090312)2.71583253
91regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.71536037
92actomyosin structure organization (GO:0031032)2.70574188
93regulation of myeloid leukocyte mediated immunity (GO:0002886)2.70372691
94T-helper 1 type immune response (GO:0042088)2.68865432
95response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.66457036
96response to host immune response (GO:0052572)2.66457036
97detection of biotic stimulus (GO:0009595)2.66376368
98regulation of interleukin-2 biosynthetic process (GO:0045076)2.66194483
99type I interferon signaling pathway (GO:0060337)2.65844053
100cellular response to type I interferon (GO:0071357)2.65844053
101positive regulation of B cell differentiation (GO:0045579)2.65100349
102response to type I interferon (GO:0034340)2.65007692
103defense response to protozoan (GO:0042832)2.64818283
104positive regulation of glycogen biosynthetic process (GO:0045725)2.64798745
105response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.64701657
106response to host (GO:0075136)2.64701657
107response to host defenses (GO:0052200)2.64701657
108regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.64213809
109negative regulation of fatty acid transport (GO:2000192)2.63656810
110myeloid dendritic cell activation (GO:0001773)2.63598754
111regulation of type I interferon-mediated signaling pathway (GO:0060338)2.63579585
112fatty acid transmembrane transport (GO:1902001)2.62012432
113negative regulation of nucleotide catabolic process (GO:0030812)2.61757928
114positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.61468898
115B cell homeostasis (GO:0001782)2.61018244
116cellular response to thyroid hormone stimulus (GO:0097067)2.60279141
117regulation of tolerance induction (GO:0002643)2.59880214
118modulation by symbiont of host cellular process (GO:0044068)2.59477691
119cortical actin cytoskeleton organization (GO:0030866)2.58915250
120macrophage activation (GO:0042116)2.58745429
121actin filament-based movement (GO:0030048)2.58567647
122negative regulation of T cell mediated immunity (GO:0002710)2.57633419
123negative thymic T cell selection (GO:0045060)2.57493926
124regulation of antigen processing and presentation (GO:0002577)2.57430961
125regulation of mast cell activation involved in immune response (GO:0033006)2.55341618
126pinocytosis (GO:0006907)2.55099816
127negative regulation of leukocyte mediated immunity (GO:0002704)2.54906949
128regulation of ARF protein signal transduction (GO:0032012)2.54509502
129positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.54234819
130response to protozoan (GO:0001562)2.53423999
131negative T cell selection (GO:0043383)2.53421607
132myeloid cell activation involved in immune response (GO:0002275)2.52532028
133cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.51932768
134negative regulation of cytokine production involved in immune response (GO:0002719)2.51736069
135positive regulation of mast cell activation (GO:0033005)2.51660944
136maternal placenta development (GO:0001893)2.51363564
137positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.50869229
138negative regulation of lymphocyte mediated immunity (GO:0002707)2.50568984
139positive regulation of type 2 immune response (GO:0002830)2.50474490
140vascular endothelial growth factor signaling pathway (GO:0038084)2.50420505
141regulation of tight junction assembly (GO:2000810)2.48942118
142regulation of translational fidelity (GO:0006450)2.48904003
143striated muscle contraction (GO:0006941)2.48881496
144cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.48569743
145histone H3-K36 demethylation (GO:0070544)2.47370702
146barbed-end actin filament capping (GO:0051016)2.46829700
147layer formation in cerebral cortex (GO:0021819)2.46476671
148actin-mediated cell contraction (GO:0070252)2.46267686
149activation of JUN kinase activity (GO:0007257)2.45090563
150negative regulation of granulocyte differentiation (GO:0030853)2.44915176
151positive regulation of antigen processing and presentation (GO:0002579)2.44266310
152regulation of necroptotic process (GO:0060544)2.44227077
153positive regulation of fatty acid beta-oxidation (GO:0032000)2.44167608
154regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.43905108
155apoptotic process involved in morphogenesis (GO:0060561)2.42661968
156heart trabecula formation (GO:0060347)2.42538631
157glycosphingolipid catabolic process (GO:0046479)2.41640229
158cardiac muscle cell development (GO:0055013)2.40064267
159regulation of fatty acid oxidation (GO:0046320)2.39373386
160creatine metabolic process (GO:0006600)2.38403412
161positive regulation of RNA splicing (GO:0033120)2.37405240
162mRNA stabilization (GO:0048255)2.35981347
163RNA stabilization (GO:0043489)2.35981347
164negative regulation of catenin import into nucleus (GO:0035414)2.34603338
165cell migration involved in sprouting angiogenesis (GO:0002042)2.33229459
166intracellular estrogen receptor signaling pathway (GO:0030520)2.32702529
167growth hormone receptor signaling pathway (GO:0060396)2.31996046
168cell communication by electrical coupling (GO:0010644)2.31800478
169positive regulation of blood vessel endothelial cell migration (GO:0043536)2.31139359
170cardiac cell development (GO:0055006)2.30076650
171negative regulation of histone methylation (GO:0031061)2.29791283
172sarcoplasmic reticulum calcium ion transport (GO:0070296)2.27689881
173regulation of skeletal muscle contraction (GO:0014819)2.27082604
174negative regulation of purine nucleotide catabolic process (GO:0033122)2.25946831
175peptidyl-threonine phosphorylation (GO:0018107)2.25389000
1762-oxoglutarate metabolic process (GO:0006103)2.24995701
177semaphorin-plexin signaling pathway (GO:0071526)2.24756469
178positive regulation of glycogen metabolic process (GO:0070875)2.22767199
179JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.21283215
180regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.20110887
181natural killer cell differentiation (GO:0001779)2.19446225
182oxaloacetate metabolic process (GO:0006107)2.19349882
183peptidyl-threonine modification (GO:0018210)2.19333901

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.92454791
2MYC_22102868_ChIP-Seq_BL_Human3.85849460
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.37311057
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.31943489
5KDM2B_26808549_Chip-Seq_SUP-B15_Human3.11645155
6KDM2B_26808549_Chip-Seq_DND41_Human3.08654324
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.93255551
8* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.76182300
9TCF7_22412390_ChIP-Seq_EML_Mouse2.74490756
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67525395
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.64654890
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.59323684
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.54720377
14VDR_21846776_ChIP-Seq_THP-1_Human2.53211256
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43389432
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.38816576
17* IRF8_27001747_Chip-Seq_BMDM_Mouse2.37912929
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.34326734
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.27715351
20ZNF263_19887448_ChIP-Seq_K562_Human2.26321153
21* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.22169506
22LXR_22292898_ChIP-Seq_THP-1_Human2.16671461
23KDM2B_26808549_Chip-Seq_JURKAT_Human2.15265381
24* KDM2B_26808549_Chip-Seq_K562_Human2.05275269
25MAF_26560356_Chip-Seq_TH1_Human2.00562650
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.98519304
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.97706300
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.95251250
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95165115
30UTX_26944678_Chip-Seq_JUKART_Human1.90168889
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89127951
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87036033
33ZFP281_27345836_Chip-Seq_ESCs_Mouse1.84505694
34P300_27058665_Chip-Seq_ZR-75-30cells_Human1.79539641
35* RUNX1_22412390_ChIP-Seq_EML_Mouse1.78394781
36CLOCK_20551151_ChIP-Seq_293T_Human1.75442751
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75387617
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.75119373
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73959601
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72867158
41DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.72658639
42* TBX20_22080862_ChIP-Seq_HEART_Mouse1.71445884
43* TBX20_22328084_ChIP-Seq_HEART_Mouse1.71445884
44* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71042036
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.71023969
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69903642
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67091892
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66805173
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.65866407
50RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.64320057
51RACK7_27058665_Chip-Seq_MCF-7_Human1.63809795
52* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.63140940
53* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60976608
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.59845970
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57923222
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57221158
57SPI1_23127762_ChIP-Seq_K562_Human1.52398856
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50632529
59SPI1_23547873_ChIP-Seq_NB4_Human1.50466584
60* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44546896
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42109534
62VDR_24763502_ChIP-Seq_THP-1_Human1.41823371
63RUNX_20019798_ChIP-Seq_JUKART_Human1.36900968
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36866549
65CREB1_26743006_Chip-Seq_LNCaP_Human1.35995851
66VDR_24787735_ChIP-Seq_THP-1_Human1.35261537
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33722029
68MAF_26560356_Chip-Seq_TH2_Human1.33198291
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33070264
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32512686
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.32176705
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32116143
73NCOR1_26117541_ChIP-Seq_K562_Human1.31665924
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31307016
75* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30930001
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30247152
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30235087
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30115050
79ATF3_27146783_Chip-Seq_COLON_Human1.29227602
80DROSHA_22980978_ChIP-Seq_HELA_Human1.28831148
81FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.27692861
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25628425
83* RUNX1_27514584_Chip-Seq_MCF-7_Human1.25315835
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24935827
85GATA1_19941826_ChIP-Seq_K562_Human1.24738588
86* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24224712
87* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22969770
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21816534
89PU_27001747_Chip-Seq_BMDM_Mouse1.20275607
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19934292
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18255144
92TP53_22127205_ChIP-Seq_IMR90_Human1.17198398
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15327969
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15021902
95FOXO3_23340844_ChIP-Seq_DLD1_Human1.14975789
96* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14596757
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14548086
98RARB_27405468_Chip-Seq_BRAIN_Mouse1.13377368
99MYB_26560356_Chip-Seq_TH1_Human1.13316277
100CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13107658
101P68_20966046_ChIP-Seq_HELA_Human1.13098036
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12173721
103TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.11790129
104NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09626237
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09481073
106HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09424337
107MYB_26560356_Chip-Seq_TH2_Human1.08575859
108* GATA1_19941827_ChIP-Seq_MEL_Mouse1.08176986
109* SMC4_20622854_ChIP-Seq_HELA_Human1.08114664
110GATA1_22025678_ChIP-Seq_K562_Human1.07344927
111ELF1_20517297_ChIP-Seq_JURKAT_Human1.07264763
112NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06987751
113ESR1_20079471_ChIP-ChIP_T-47D_Human1.06546354
114SCL_19346495_ChIP-Seq_HPC-7_Human1.05996386
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04970174
116PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04940200
117* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01399858
118CTCF_21964334_ChIP-Seq_BJAB-B_Human1.00988439
119LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00791028
120NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97491323
121CTCF_21964334_Chip-Seq_Bcells_Human0.96551423
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.96011379
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95943313
124SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95361708
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93649570
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93128266
127EP300_21415370_ChIP-Seq_HL-1_Mouse0.92624981
128* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92277752
129CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91255654
130TP63_22573176_ChIP-Seq_HFKS_Human0.90697166
131SA1_27219007_Chip-Seq_ERYTHROID_Human0.90016932
132TP63_17297297_ChIP-ChIP_HaCaT_Human0.89594822
133STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88269799
134* FOXA2_19822575_ChIP-Seq_HepG2_Human0.87971663
135GATA2_19941826_ChIP-Seq_K562_Human0.87891640

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.81097303
2MP0000751_myopathy3.55434837
3MP0003436_decreased_susceptibility_to3.46661762
4MP0003303_peritoneal_inflammation3.12922661
5MP0002837_dystrophic_cardiac_calcinosis3.11994845
6MP0001835_abnormal_antigen_presentation2.86040674
7MP0005058_abnormal_lysosome_morphology2.83589611
8MP0004084_abnormal_cardiac_muscle2.79540218
9MP0003646_muscle_fatigue2.73614580
10MP0005451_abnormal_body_composition2.70870910
11MP0004130_abnormal_muscle_cell2.70716210
12MP0004087_abnormal_muscle_fiber2.66974441
13MP0004510_myositis2.59262246
14MP0005000_abnormal_immune_tolerance2.50940289
15MP0005076_abnormal_cell_differentiation2.47878819
16MP0002419_abnormal_innate_immunity2.46544166
17MP0003724_increased_susceptibility_to2.46503232
18MP0003300_gastrointestinal_ulcer2.46185465
19MP0003172_abnormal_lysosome_physiology2.45625057
20MP0005671_abnormal_response_to2.43710147
21MP0004185_abnormal_adipocyte_glucose2.38540381
22MP0010352_gastrointestinal_tract_polyps2.35474015
23MP0000749_muscle_degeneration2.32188774
24MP0008961_abnormal_basal_metabolism2.25221296
25MP0000733_abnormal_muscle_development2.24358967
26MP0009840_abnormal_foam_cell2.23813694
27MP0006082_CNS_inflammation2.23543570
28MP0005025_abnormal_response_to2.23432566
29MP0002452_abnormal_antigen_presenting2.18127894
30MP0010630_abnormal_cardiac_muscle2.14917666
31MP0000750_abnormal_muscle_regeneration2.10953622
32MP0002148_abnormal_hypersensitivity_rea2.08923592
33MP0002723_abnormal_immune_serum2.07324448
34MP0004036_abnormal_muscle_relaxation2.07324216
35MP0005666_abnormal_adipose_tissue2.02095536
36MP0009785_altered_susceptibility_to2.02068983
37MP0005330_cardiomyopathy2.01913724
38MP0002420_abnormal_adaptive_immunity1.99029275
39MP0000747_muscle_weakness1.98912120
40MP0001819_abnormal_immune_cell1.96782743
41MP0003191_abnormal_cellular_cholesterol1.96767808
42MP0002106_abnormal_muscle_physiology1.93896238
43MP0000759_abnormal_skeletal_muscle1.91352875
44MP0009278_abnormal_bone_marrow1.88962047
45MP0005623_abnormal_meninges_morphology1.85973330
46MP0005375_adipose_tissue_phenotype1.84223980
47MP0002269_muscular_atrophy1.82303700
48MP0002998_abnormal_bone_remodeling1.79857446
49MP0004145_abnormal_muscle_electrophysio1.77340914
50MP0001533_abnormal_skeleton_physiology1.75498966
51MP0004233_abnormal_muscle_weight1.74393889
52MP0004215_abnormal_myocardial_fiber1.73820749
53MP0008260_abnormal_autophagy1.71782545
54MP0002405_respiratory_system_inflammati1.68569941
55MP0005464_abnormal_platelet_physiology1.67113966
56MP0009333_abnormal_splenocyte_physiolog1.63879409
57MP0000003_abnormal_adipose_tissue1.63107650
58MP0000604_amyloidosis1.60809896
59MP0005670_abnormal_white_adipose1.58928764
60MP0010155_abnormal_intestine_physiology1.57643876
61MP0002877_abnormal_melanocyte_morpholog1.56104546
62MP0000716_abnormal_immune_system1.54120374
63MP0003075_altered_response_to1.50531952
64MP0000858_altered_metastatic_potential1.48615244
65* MP0003566_abnormal_cell_adhesion1.47380628
66MP0005369_muscle_phenotype1.47318507
67MP0003279_aneurysm1.46679052
68MP0001544_abnormal_cardiovascular_syste1.44754033
69MP0005385_cardiovascular_system_phenoty1.44754033
70MP0001845_abnormal_inflammatory_respons1.44382501
71MP0005620_abnormal_muscle_contractility1.40661752
72MP0008775_abnormal_heart_ventricle1.39033645
73MP0001853_heart_inflammation1.38168984
74MP0005310_abnormal_salivary_gland1.33601370
75MP0002972_abnormal_cardiac_muscle1.33000636
76MP0003690_abnormal_glial_cell1.32876153
77MP0003828_pulmonary_edema1.32770937
78MP0003453_abnormal_keratinocyte_physiol1.29716232
79MP0000343_altered_response_to1.28763167
80MP0003045_fibrosis1.28326394
81MP0003763_abnormal_thymus_physiology1.27083117
82MP0000685_abnormal_immune_system1.27040146
83MP0010368_abnormal_lymphatic_system1.26356002
84MP0000569_abnormal_digit_pigmentation1.26183841
85* MP0003091_abnormal_cell_migration1.25164189
86MP0002429_abnormal_blood_cell1.21899150
87MP0004808_abnormal_hematopoietic_stem1.21487576
88MP0000689_abnormal_spleen_morphology1.20206354
89MP0000266_abnormal_heart_morphology1.17993989
90MP0002722_abnormal_immune_system1.17988499
91MP0003448_altered_tumor_morphology1.17230828
92MP0008438_abnormal_cutaneous_collagen1.16497749
93MP0008469_abnormal_protein_level1.15721087
94MP0005166_decreased_susceptibility_to1.15593301
95MP0001545_abnormal_hematopoietic_system1.13884858
96MP0001348_abnormal_lacrimal_gland1.12714503
97MP0003329_amyloid_beta_deposits1.11954562
98MP0004859_abnormal_synaptic_plasticity1.10714251
99MP0009764_decreased_sensitivity_to1.08399197
100MP0002925_abnormal_cardiovascular_devel1.08393960
101MP0003221_abnormal_cardiomyocyte_apopto1.07490779
102MP0001849_ear_inflammation1.06649838
103MP0006138_congestive_heart_failure1.04421952
104MP0000013_abnormal_adipose_tissue1.04010632
105MP0003137_abnormal_impulse_conducting1.01932392
106MP0001873_stomach_inflammation1.01519813
107MP0004484_altered_response_of1.00294103
108* MP0002128_abnormal_blood_circulation0.99772053
109MP0002933_joint_inflammation0.99536367
110MP0002166_altered_tumor_susceptibility0.98352417
111MP0003183_abnormal_peptide_metabolism0.97279015
112MP0001851_eye_inflammation0.97113478
113MP0009780_abnormal_chondrocyte_physiolo0.96752237
114MP0005023_abnormal_wound_healing0.96349173
115MP0000703_abnormal_thymus_morphology0.95306070
116MP0002909_abnormal_adrenal_gland0.94786782
117MP0001800_abnormal_humoral_immune0.94040543
118MP0004197_abnormal_fetal_growth/weight/0.93607256
119MP0002089_abnormal_postnatal_growth/wei0.93242506
120MP0002088_abnormal_embryonic_growth/wei0.93191407
121MP0002138_abnormal_hepatobiliary_system0.93076976
122MP0003984_embryonic_growth_retardation0.92994129
123MP0000465_gastrointestinal_hemorrhage0.91891131
124MP0003567_abnormal_fetal_cardiomyocyte0.91334992
125MP0004858_abnormal_nervous_system0.91128363
126MP0005387_immune_system_phenotype0.90013225
127MP0001790_abnormal_immune_system0.90013225
128MP0005409_darkened_coat_color0.89620003
129MP0002332_abnormal_exercise_endurance0.88766258
130MP0010234_abnormal_vibrissa_follicle0.88746348
131MP0005187_abnormal_penis_morphology0.87966112
132MP0002254_reproductive_system_inflammat0.87960407
133MP0001879_abnormal_lymphatic_vessel0.87065104
134MP0004381_abnormal_hair_follicle0.86989391
135MP0008770_decreased_survivor_rate0.86645914
136MP0000249_abnormal_blood_vessel0.85253470
137MP0002234_abnormal_pharynx_morphology0.85057717
138MP0005167_abnormal_blood-brain_barrier0.84122200
139MP0003866_abnormal_defecation0.83882697
140MP0004883_abnormal_blood_vessel0.83415523
141MP0008874_decreased_physiological_sensi0.82269529
142MP0002398_abnormal_bone_marrow0.81929844
143MP0002971_abnormal_brown_adipose0.80781364
144MP0002086_abnormal_extraembryonic_tissu0.80558963
145MP0002396_abnormal_hematopoietic_system0.79495111
146MP0002127_abnormal_cardiovascular_syste0.77708077
147MP0004085_abnormal_heartbeat0.77691189
148MP0001915_intracranial_hemorrhage0.77659916
149* MP0000767_abnormal_smooth_muscle0.77460968
150MP0005390_skeleton_phenotype0.76391111
151MP0001730_embryonic_growth_arrest0.75582624
152MP0000920_abnormal_myelination0.74499807
153MP0001672_abnormal_embryogenesis/_devel0.72507913
154MP0005380_embryogenesis_phenotype0.72507913
155MP0004947_skin_inflammation0.72276654
156MP0008004_abnormal_stomach_pH0.72159499
157* MP0001784_abnormal_fluid_regulation0.71404168
158MP0001958_emphysema0.71143985
159MP0001663_abnormal_digestive_system0.70938053
160MP0003795_abnormal_bone_structure0.70840079
161MP0009672_abnormal_birth_weight0.70263376
162MP0002108_abnormal_muscle_morphology0.68363257
163MP0009115_abnormal_fat_cell0.67258456
164MP0005397_hematopoietic_system_phenotyp0.66677094

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.63650957
2Difficulty running (HP:0009046)4.04727211
3Abnormality of macrophages (HP:0004311)3.95149189
4Hyporeflexia of lower limbs (HP:0002600)3.93639564
5Increased connective tissue (HP:0009025)3.91456361
6Sudden death (HP:0001699)3.76274918
7Recurrent bacterial skin infections (HP:0005406)3.73354329
8Abnormality of glycolipid metabolism (HP:0010969)3.72216550
9Abnormality of liposaccharide metabolism (HP:0010968)3.72216550
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.72216550
11Exercise-induced myalgia (HP:0003738)3.68109973
12Recurrent abscess formation (HP:0002722)3.63392273
13Cerebral aneurysm (HP:0004944)3.49951897
14Muscle fiber splitting (HP:0003555)3.49527565
15Exercise-induced muscle cramps (HP:0003710)3.43448529
16Type 1 muscle fiber predominance (HP:0003803)3.21691286
17Mediastinal lymphadenopathy (HP:0100721)3.12417749
18Difficulty climbing stairs (HP:0003551)3.11246811
19Increased cerebral lipofuscin (HP:0011813)3.08577382
20Hyperacusis (HP:0010780)3.03966262
21Dysostosis multiplex (HP:0000943)3.00238191
22Cellulitis (HP:0100658)2.97945841
23Recurrent gram-negative bacterial infections (HP:0005420)2.97352438
24Spontaneous hematomas (HP:0007420)2.95690096
25Abnormality of the left ventricular outflow tract (HP:0011103)2.88426559
26Subaortic stenosis (HP:0001682)2.88426559
27Muscle fiber inclusion bodies (HP:0100299)2.83909510
28Ventricular tachycardia (HP:0004756)2.80534783
29Myositis (HP:0100614)2.76213080
30Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.75963491
31Myoglobinuria (HP:0002913)2.73333970
32Gastrointestinal stroma tumor (HP:0100723)2.73232999
33EMG: myopathic abnormalities (HP:0003458)2.72993306
34Dysmetric saccades (HP:0000641)2.72521492
35Increased variability in muscle fiber diameter (HP:0003557)2.72374383
36Protrusio acetabuli (HP:0003179)2.72019075
37Meningitis (HP:0001287)2.70281810
38Abnormality of skeletal muscle fiber size (HP:0012084)2.69371319
39Orchitis (HP:0100796)2.69151685
40Calf muscle hypertrophy (HP:0008981)2.68141151
41Bundle branch block (HP:0011710)2.66054108
42Recurrent fungal infections (HP:0002841)2.62173522
43Increased density of long bones (HP:0006392)2.61999339
44Recurrent viral infections (HP:0004429)2.61879610
45Achilles tendon contracture (HP:0001771)2.61282070
46Lower limb amyotrophy (HP:0007210)2.56244168
47Shallow orbits (HP:0000586)2.56219324
48Frequent falls (HP:0002359)2.55737634
49Abnormality of the calf musculature (HP:0001430)2.55474473
50Distal lower limb amyotrophy (HP:0008944)2.54532510
51Muscle hypertrophy of the lower extremities (HP:0008968)2.54293565
52Asymmetric septal hypertrophy (HP:0001670)2.52702977
53Systemic lupus erythematosus (HP:0002725)2.51490606
54Loss of speech (HP:0002371)2.49226084
55Retrobulbar optic neuritis (HP:0100654)2.48547693
56Optic neuritis (HP:0100653)2.48547693
57Gingivitis (HP:0000230)2.47441809
58Increased IgE level (HP:0003212)2.46769782
59Scapular winging (HP:0003691)2.44610570
60Obstructive lung disease (HP:0006536)2.44130751
61Chronic obstructive pulmonary disease (HP:0006510)2.44130751
62Vasculitis (HP:0002633)2.42431634
63Rectal prolapse (HP:0002035)2.41012647
64Abnormality of the Achilles tendon (HP:0005109)2.40817465
65Vacuolated lymphocytes (HP:0001922)2.40452498
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.40098325
67Round ear (HP:0100830)2.39926840
68Recurrent skin infections (HP:0001581)2.36717008
69Limb-girdle muscle atrophy (HP:0003797)2.35580839
70Myocardial infarction (HP:0001658)2.33147616
71Autoimmune thrombocytopenia (HP:0001973)2.32028722
72Gastrointestinal infarctions (HP:0005244)2.31648887
73Mitral valve prolapse (HP:0001634)2.30577223
74Mucopolysacchariduria (HP:0008155)2.30245770
75Urinary glycosaminoglycan excretion (HP:0003541)2.30245770
76Gastrointestinal inflammation (HP:0004386)2.29296905
77Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29070106
78Abnormality of polysaccharide metabolism (HP:0011012)2.29070106
79Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29070106
80Right ventricular cardiomyopathy (HP:0011663)2.27377741
81Neurofibrillary tangles (HP:0002185)2.26926197
82Distal upper limb amyotrophy (HP:0007149)2.26196806
83Upper limb amyotrophy (HP:0009129)2.26196806
84Inflammation of the large intestine (HP:0002037)2.24628294
85Lymphangioma (HP:0100764)2.23949465
86Restrictive lung disease (HP:0002091)2.19870796
87Emphysema (HP:0002097)2.18935417
88Agammaglobulinemia (HP:0004432)2.17904017
89Obstructive sleep apnea (HP:0002870)2.17629701
90Recurrent cutaneous fungal infections (HP:0011370)2.17175559
91Chronic mucocutaneous candidiasis (HP:0002728)2.17175559
92Macroorchidism (HP:0000053)2.15040080
93Lipoatrophy (HP:0100578)2.14751435
94Aneurysm (HP:0002617)2.14334099
95Broad metatarsal (HP:0001783)2.13621273
96Atrial fibrillation (HP:0005110)2.13252368
97Ulnar deviation of the wrist (HP:0003049)2.12593751
98Neuronal loss in central nervous system (HP:0002529)2.12123523
99Primary atrial arrhythmia (HP:0001692)2.11314770
100Elfin facies (HP:0004428)2.10632839
101Myotonia (HP:0002486)2.10362714
102Mildly elevated creatine phosphokinase (HP:0008180)2.09596105
103Chest pain (HP:0100749)2.08326855
104EMG: neuropathic changes (HP:0003445)2.07542949
105Atrioventricular block (HP:0001678)2.05989374
106Segmental peripheral demyelination/remyelination (HP:0003481)2.05568527
107Nemaline bodies (HP:0003798)2.05442250
108Pulmonary infiltrates (HP:0002113)2.04819052
109T lymphocytopenia (HP:0005403)2.04327598
110Supraventricular arrhythmia (HP:0005115)2.03531453
111Verrucae (HP:0200043)2.03126061
112Papilloma (HP:0012740)2.03126061
113Abnormality of the nasal mucosa (HP:0000433)2.02772467
114Distal lower limb muscle weakness (HP:0009053)2.01424982
115Cerebral inclusion bodies (HP:0100314)2.01305938
116Abnormal delayed hypersensitivity skin test (HP:0002963)2.00633663
117Supraventricular tachycardia (HP:0004755)1.99227714
118Slow saccadic eye movements (HP:0000514)1.98730117
119Osteomyelitis (HP:0002754)1.98629135
120Thoracic kyphosis (HP:0002942)1.97962717
121Subacute progressive viral hepatitis (HP:0006572)1.96462757
122Thin bony cortex (HP:0002753)1.95996285
123Nasal polyposis (HP:0100582)1.93566522
124Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93501609
125Aortic aneurysm (HP:0004942)1.93021642
126Stomatitis (HP:0010280)1.92662314
127Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.92548485
128Short 4th metacarpal (HP:0010044)1.92548485
129Pointed chin (HP:0000307)1.92082431
130Amyloidosis (HP:0011034)1.91878108
131Hemoptysis (HP:0002105)1.91041666
132Fatigue (HP:0012378)1.90421340
133Abnormal atrioventricular conduction (HP:0005150)1.89953823
134Abnormality of the lower motor neuron (HP:0002366)1.89393027
135Abnormality of the fingertips (HP:0001211)1.88647532
136Myopathic facies (HP:0002058)1.88581549
137Heart block (HP:0012722)1.88434043
138Insomnia (HP:0100785)1.86485561
139Distal arthrogryposis (HP:0005684)1.86338120
140Abnormality of the 4th metacarpal (HP:0010012)1.85768692
141Urticaria (HP:0001025)1.85718116
142Purpura (HP:0000979)1.85637055
143Renovascular hypertension (HP:0100817)1.85179503
144Dilatation of the ascending aorta (HP:0005111)1.84688789
145Colitis (HP:0002583)1.84517832
146Centrally nucleated skeletal muscle fibers (HP:0003687)1.83860827
147Interstitial pulmonary disease (HP:0006530)1.81802759
148Elevated erythrocyte sedimentation rate (HP:0003565)1.81570996
149Disinhibition (HP:0000734)1.81430497
150Pelvic girdle muscle weakness (HP:0003749)1.79091655
151Apathy (HP:0000741)1.79008521
152Genu recurvatum (HP:0002816)1.78585275
153Vertebral arch anomaly (HP:0008438)1.77962756
154Bowel diverticulosis (HP:0005222)1.77923697
155Viral hepatitis (HP:0006562)1.77871736
156Broad face (HP:0000283)1.77747432
157Lymphopenia (HP:0001888)1.77433136
158Bladder diverticulum (HP:0000015)1.76081227
159Keratoconjunctivitis sicca (HP:0001097)1.75839368
160Persistence of primary teeth (HP:0006335)1.75565908
161Hematochezia (HP:0002573)1.74690396
162Supranuclear gaze palsy (HP:0000605)1.74631008
163Abnormality of T cell number (HP:0011839)1.74388170
164Pustule (HP:0200039)1.74320815
165Limb-girdle muscle weakness (HP:0003325)1.74301106
166Arterial thrombosis (HP:0004420)1.73493569
167Epistaxis (HP:0000421)1.73147832
168Panhypogammaglobulinemia (HP:0003139)1.71810981
169Axonal loss (HP:0003447)1.71482870
170Encephalitis (HP:0002383)1.71090772
171Diminished motivation (HP:0000745)1.70577203
172Rhabdomyolysis (HP:0003201)1.70468488
173Polygenic inheritance (HP:0010982)1.69862433
174Abnormality of the thoracic spine (HP:0100711)1.69810492
175Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.69794446
176Hand muscle atrophy (HP:0009130)1.68902954
177Enlarged penis (HP:0000040)1.68746074
178Proximal amyotrophy (HP:0007126)1.67031631
179Striae distensae (HP:0001065)1.66584327
180Fibroma (HP:0010614)1.65532917
181Facial diplegia (HP:0001349)1.65269218
182Ulnar bowing (HP:0003031)1.64576838
183Fibrous tissue neoplasm (HP:0012316)1.64336625
184Ankle contracture (HP:0006466)1.64264965
185Abnormality of the musculature of the pelvis (HP:0001469)1.63624501
186Abnormality of the hip-girdle musculature (HP:0001445)1.63624501
187Hypercortisolism (HP:0001578)1.63076098

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.97541488
2PRPF4B4.08557933
3PKN23.95636056
4TTN3.69699253
5EEF2K3.25271438
6RIPK43.05692271
7MAP3K102.91177955
8RIPK12.83441997
9IRAK32.41809859
10BLK2.26576035
11MAP4K12.26177333
12MAP3K132.25272359
13MAP3K142.22852992
14ICK2.16768058
15DMPK2.11113064
16CDK122.02409335
17SMG11.83199779
18SIK21.78334102
19SIK11.74195162
20PDGFRA1.64250519
21TAOK11.62987876
22IRAK41.62242129
23PTK61.61940442
24PHKG11.60085650
25PHKG21.60085650
26ERN11.56262044
27ALK1.51817224
28TYRO31.43100448
29PRKD31.43098781
30MAP3K71.41545285
31FGFR41.35365532
32FGFR31.35102590
33CAMK1G1.23666424
34TAOK21.23372599
35OBSCN1.22651864
36PRKCH1.18129500
37LRRK21.16318776
38FGR1.15519466
39MAP2K31.13570001
40MAP3K11.12024281
41BMX1.11924585
42IKBKE1.11017030
43MTOR1.07374461
44CAMK1D1.05259621
45EPHB11.01216494
46SIK30.94238316
47TNK20.91719184
48NEK90.90794940
49MOS0.90163419
50JAK10.89745274
51RET0.88118828
52MATK0.87890589
53STK100.87757138
54GRK60.87016171
55PRKD10.84701560
56JAK30.82332032
57MARK20.81221139
58CSK0.80788808
59PDGFRB0.79712493
60TGFBR20.79700282
61RPS6KL10.77289629
62RPS6KC10.77289629
63MAPK70.77172429
64IKBKB0.76264629
65IRAK20.75511336
66PAK60.73441294
67LYN0.73115525
68STK240.72537440
69STK380.71766621
70LCK0.71538689
71NEK10.71246960
72PDK10.71207286
73CDK60.71124166
74PRKD20.70405617
75STK110.69432640
76CAMKK10.69313630
77LMTK20.68931639
78CDC42BPA0.67842576
79MAPK120.67720871
80DDR20.65657955
81PAK20.65292756
82NME20.64707388
83KSR20.62659471
84MAP3K90.61202412
85ARAF0.60292484
86PDK30.60224858
87PDK40.60224858
88CHUK0.59742349
89* HCK0.59280172
90RPS6KA20.59217427
91DYRK1B0.59157240
92MARK30.58341058
93TYK20.58052580
94RPS6KA60.57016777
95JAK20.56745721
96ILK0.56591779
97CSF1R0.56101420
98ZAP700.55971828
99RPS6KA10.55820836
100ITK0.55788840
101KIT0.55630572
102PTK2B0.55134305
103LATS20.55056994
104FGFR10.54699513
105PDPK10.54648419
106FES0.53880784
107HIPK20.53072012
108TXK0.52772070
109CDK40.52746889
110GRK70.51429498
111SGK30.50173841
112PAK40.49890001
113MAPK40.47656218
114SCYL20.46949061
115TBK10.46736299
116MAP3K80.46237906
117MAP3K20.45206194
118TRPM70.44766885
119PTK20.43414901
120MAP3K110.43260507
121LATS10.43007410
122PRKAA10.42932584
123BMPR20.42741909
124AKT20.42464216
125IRAK10.41286676
126FYN0.40939952
127TIE10.40937086
128NEK20.39877111
129BRD40.39790164
130MAP3K30.38907490
131PAK30.36914547
132CAMK40.36893154
133BTK0.36074895
134FGFR20.35504154
135SYK0.35187668
136RPS6KA40.35132725
137MARK10.34009343
138MAPK110.33606452

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.35317324
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.16382408
3Staphylococcus aureus infection_Homo sapiens_hsa051501.96063254
4Toll-like receptor signaling pathway_Homo sapiens_hsa046201.95961744
5Dilated cardiomyopathy_Homo sapiens_hsa054141.92457655
6Viral myocarditis_Homo sapiens_hsa054161.90368340
7Allograft rejection_Homo sapiens_hsa053301.88305872
8Chronic myeloid leukemia_Homo sapiens_hsa052201.83577130
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.81716432
10B cell receptor signaling pathway_Homo sapiens_hsa046621.78185666
11Tuberculosis_Homo sapiens_hsa051521.75496082
12Graft-versus-host disease_Homo sapiens_hsa053321.75085022
13Autoimmune thyroid disease_Homo sapiens_hsa053201.69416852
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.68187456
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57286320
16mTOR signaling pathway_Homo sapiens_hsa041501.56696874
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56449051
18Insulin resistance_Homo sapiens_hsa049311.48047846
19Lysosome_Homo sapiens_hsa041421.45865949
20VEGF signaling pathway_Homo sapiens_hsa043701.44931608
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43644424
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.42215853
23Influenza A_Homo sapiens_hsa051641.39549278
24Acute myeloid leukemia_Homo sapiens_hsa052211.37788796
25Nitrogen metabolism_Homo sapiens_hsa009101.35204021
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34076643
27Lysine degradation_Homo sapiens_hsa003101.33471861
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33347305
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.31488979
30Thyroid hormone signaling pathway_Homo sapiens_hsa049191.30421306
31Non-small cell lung cancer_Homo sapiens_hsa052231.30190854
32* Focal adhesion_Homo sapiens_hsa045101.29297742
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28287038
34Malaria_Homo sapiens_hsa051441.28266728
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.28076323
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27486079
37Asthma_Homo sapiens_hsa053101.26864880
38T cell receptor signaling pathway_Homo sapiens_hsa046601.26765139
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26659538
40Glioma_Homo sapiens_hsa052141.24848894
41Type I diabetes mellitus_Homo sapiens_hsa049401.24777146
42Proteoglycans in cancer_Homo sapiens_hsa052051.24228535
43Endometrial cancer_Homo sapiens_hsa052131.22564143
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21317265
45Antigen processing and presentation_Homo sapiens_hsa046121.19612040
46* Neurotrophin signaling pathway_Homo sapiens_hsa047221.18775433
47Type II diabetes mellitus_Homo sapiens_hsa049301.18770368
48Osteoclast differentiation_Homo sapiens_hsa043801.17719921
49Rheumatoid arthritis_Homo sapiens_hsa053231.17140516
50Primary immunodeficiency_Homo sapiens_hsa053401.16906931
51Central carbon metabolism in cancer_Homo sapiens_hsa052301.16725590
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.16689560
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16556348
54Glucagon signaling pathway_Homo sapiens_hsa049221.15485575
55Pertussis_Homo sapiens_hsa051331.15121387
56* Insulin signaling pathway_Homo sapiens_hsa049101.14998401
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13686747
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13119267
59Dorso-ventral axis formation_Homo sapiens_hsa043201.12088980
60AMPK signaling pathway_Homo sapiens_hsa041521.11733231
61Adherens junction_Homo sapiens_hsa045201.11593818
62Glycosaminoglycan degradation_Homo sapiens_hsa005311.09875773
63Platelet activation_Homo sapiens_hsa046111.09747761
64Estrogen signaling pathway_Homo sapiens_hsa049151.09543203
65Pancreatic cancer_Homo sapiens_hsa052121.09066877
66Hematopoietic cell lineage_Homo sapiens_hsa046401.08643205
67Hepatitis C_Homo sapiens_hsa051601.08572462
68Phagosome_Homo sapiens_hsa041451.07680637
69Herpes simplex infection_Homo sapiens_hsa051681.07156817
70cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07015551
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06658211
72Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06581894
73Oxytocin signaling pathway_Homo sapiens_hsa049211.00747230
74Colorectal cancer_Homo sapiens_hsa052100.99531425
75Small cell lung cancer_Homo sapiens_hsa052220.98882702
76Salmonella infection_Homo sapiens_hsa051320.98201672
77Toxoplasmosis_Homo sapiens_hsa051450.97789556
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96775979
79MicroRNAs in cancer_Homo sapiens_hsa052060.96470512
80Notch signaling pathway_Homo sapiens_hsa043300.96418254
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96171872
82Prion diseases_Homo sapiens_hsa050200.94328784
83Legionellosis_Homo sapiens_hsa051340.92041631
84* Renal cell carcinoma_Homo sapiens_hsa052110.91672226
85GnRH signaling pathway_Homo sapiens_hsa049120.90006489
86HIF-1 signaling pathway_Homo sapiens_hsa040660.89710243
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.86023980
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.85481537
89Amoebiasis_Homo sapiens_hsa051460.85182262
90Long-term potentiation_Homo sapiens_hsa047200.84410683
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83144224
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83135120
93HTLV-I infection_Homo sapiens_hsa051660.81982310
94Prolactin signaling pathway_Homo sapiens_hsa049170.81827702
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80671576
96MAPK signaling pathway_Homo sapiens_hsa040100.80542963
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80225756
98Gastric acid secretion_Homo sapiens_hsa049710.78057479
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77154703
100ErbB signaling pathway_Homo sapiens_hsa040120.76481775
101Chemokine signaling pathway_Homo sapiens_hsa040620.75976352
102Renin secretion_Homo sapiens_hsa049240.75208331
103Cholinergic synapse_Homo sapiens_hsa047250.73908349
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71832056
105Gap junction_Homo sapiens_hsa045400.70544052
106Hepatitis B_Homo sapiens_hsa051610.70059479
107African trypanosomiasis_Homo sapiens_hsa051430.69365205
108Arginine biosynthesis_Homo sapiens_hsa002200.68399927
109FoxO signaling pathway_Homo sapiens_hsa040680.67849532
110* Rap1 signaling pathway_Homo sapiens_hsa040150.67719023
111Epstein-Barr virus infection_Homo sapiens_hsa051690.65883698
112Tight junction_Homo sapiens_hsa045300.65209671
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64245159
114Prostate cancer_Homo sapiens_hsa052150.63970868
115Olfactory transduction_Homo sapiens_hsa047400.62663916
116Endocytosis_Homo sapiens_hsa041440.62202985
117Apoptosis_Homo sapiens_hsa042100.61987305
118ECM-receptor interaction_Homo sapiens_hsa045120.61837222
119Inositol phosphate metabolism_Homo sapiens_hsa005620.58766995
120Leishmaniasis_Homo sapiens_hsa051400.57531578
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56153443
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.55992060
123Bladder cancer_Homo sapiens_hsa052190.55227243
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55054630
125Circadian entrainment_Homo sapiens_hsa047130.54537224
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54247446
127TNF signaling pathway_Homo sapiens_hsa046680.53865069
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.53792540
129Shigellosis_Homo sapiens_hsa051310.53694209
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.53592877
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53549260
132Melanogenesis_Homo sapiens_hsa049160.53503189
133Viral carcinogenesis_Homo sapiens_hsa052030.53375586
134PPAR signaling pathway_Homo sapiens_hsa033200.53125482
135Choline metabolism in cancer_Homo sapiens_hsa052310.52595742
136Fatty acid biosynthesis_Homo sapiens_hsa000610.52553176
137Measles_Homo sapiens_hsa051620.52324821

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