RAPGEF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)4.20028048
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.18576427
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.08589345
4locomotory exploration behavior (GO:0035641)4.06262468
5vocalization behavior (GO:0071625)4.03065449
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.01347609
7regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.96242875
8regulation of glutamate receptor signaling pathway (GO:1900449)3.86946244
9melanin metabolic process (GO:0006582)3.73265702
10ionotropic glutamate receptor signaling pathway (GO:0035235)3.68226660
11synaptic vesicle docking involved in exocytosis (GO:0016081)3.62135188
12regulation of fever generation (GO:0031620)3.59646851
13synaptic vesicle maturation (GO:0016188)3.54418135
14neurotransmitter-gated ion channel clustering (GO:0072578)3.48630885
15positive regulation of heat generation (GO:0031652)3.47110583
16regulation of synaptic vesicle exocytosis (GO:2000300)3.36402115
17synaptic vesicle exocytosis (GO:0016079)3.36233585
18glutamate secretion (GO:0014047)3.32014865
19secondary metabolite biosynthetic process (GO:0044550)3.31981849
20cellular response to ethanol (GO:0071361)3.28682047
21protein localization to synapse (GO:0035418)3.27849552
22glutamate receptor signaling pathway (GO:0007215)3.22382892
23neuron cell-cell adhesion (GO:0007158)3.21161520
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.20985601
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.18203131
26regulation of excitatory postsynaptic membrane potential (GO:0060079)3.11172922
27regulation of neuronal synaptic plasticity (GO:0048168)3.09311817
28regulation of heat generation (GO:0031650)3.08517044
29synaptic vesicle endocytosis (GO:0048488)3.06969715
30synaptic transmission, glutamatergic (GO:0035249)3.06383451
31regulation of synaptic vesicle transport (GO:1902803)3.02678049
32regulation of synapse structural plasticity (GO:0051823)3.02183270
33exploration behavior (GO:0035640)2.95518504
34neuron-neuron synaptic transmission (GO:0007270)2.91592764
35regulation of vitamin D biosynthetic process (GO:0060556)2.90155328
36regulation of postsynaptic membrane potential (GO:0060078)2.88254289
37long-term synaptic potentiation (GO:0060291)2.83516910
38presynaptic membrane assembly (GO:0097105)2.78180856
39positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.76814820
40regulation of dendritic spine morphogenesis (GO:0061001)2.75595856
41positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.74568488
42long-term memory (GO:0007616)2.74036574
43positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.72867914
44neuronal action potential propagation (GO:0019227)2.71864866
45germinal center formation (GO:0002467)2.71571357
46negative regulation of interleukin-12 production (GO:0032695)2.71300345
47negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70664645
48negative regulation of neurotransmitter secretion (GO:0046929)2.67790348
49positive regulation of cellular amide metabolic process (GO:0034250)2.67106816
50developmental pigmentation (GO:0048066)2.66308096
51cerebellar Purkinje cell differentiation (GO:0021702)2.66188268
52neurotransmitter secretion (GO:0007269)2.66155969
53regulation of synaptic transmission, glutamatergic (GO:0051966)2.66068552
54response to peptidoglycan (GO:0032494)2.65172462
55* regulation of synaptic plasticity (GO:0048167)2.64158228
56negative regulation of amino acid transport (GO:0051956)2.62995388
57response to methylmercury (GO:0051597)2.59567512
58negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.59076165
59lipopolysaccharide-mediated signaling pathway (GO:0031663)2.58873194
60postsynaptic membrane organization (GO:0001941)2.58541463
61positive regulation of membrane potential (GO:0045838)2.56123234
62* nerve growth factor signaling pathway (GO:0038180)2.55754189
63positive regulation of type 2 immune response (GO:0002830)2.55711078
64response to auditory stimulus (GO:0010996)2.54193138
65hemoglobin metabolic process (GO:0020027)2.53967169
66regulation of interferon-alpha production (GO:0032647)2.53909063
67gamma-aminobutyric acid transport (GO:0015812)2.51462047
68startle response (GO:0001964)2.50429137
69positive regulation by symbiont of host defense response (GO:0052509)2.49967065
70modulation by symbiont of host defense response (GO:0052031)2.49967065
71modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.49967065
72modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.49967065
73positive regulation by organism of defense response of other organism involved in symbiotic interact2.49967065
74modulation by symbiont of host immune response (GO:0052553)2.49967065
75proline transport (GO:0015824)2.48383577
76dendritic spine morphogenesis (GO:0060997)2.47976399
77regulation of NFAT protein import into nucleus (GO:0051532)2.46766967
78regulation of neurotransmitter secretion (GO:0046928)2.46527338
79positive regulation of nitric oxide biosynthetic process (GO:0045429)2.45812996
80regulation of voltage-gated calcium channel activity (GO:1901385)2.45406469
81regulation of cytokine secretion involved in immune response (GO:0002739)2.44394600
82gamma-aminobutyric acid signaling pathway (GO:0007214)2.43691102
83G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.43517583
84presynaptic membrane organization (GO:0097090)2.41964807
85membrane depolarization (GO:0051899)2.41827689
86negative regulation of neurotransmitter transport (GO:0051589)2.40963416
87regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.40779481
88G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.40216110
89signal complex assembly (GO:0007172)2.39010831
90interleukin-6-mediated signaling pathway (GO:0070102)2.38429531
91positive regulation of synaptic transmission, GABAergic (GO:0032230)2.38105172
92regulation of dendritic spine development (GO:0060998)2.37441969
93neuron recognition (GO:0008038)2.37201246
94long term synaptic depression (GO:0060292)2.36857227
95regulation of clathrin-mediated endocytosis (GO:2000369)2.36655132
96regulation of glutamate secretion (GO:0014048)2.36540697
97response to muramyl dipeptide (GO:0032495)2.35446529
98regulation of T-helper 2 cell differentiation (GO:0045628)2.33688905
99vesicle transport along microtubule (GO:0047496)2.32005492
100positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.31662525
101positive regulation of neurotransmitter secretion (GO:0001956)2.31550485
102cAMP catabolic process (GO:0006198)2.31528847
103Rac protein signal transduction (GO:0016601)2.31091301
104transmission of nerve impulse (GO:0019226)2.30727126
105positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.29568013
106regulation of interleukin-8 biosynthetic process (GO:0045414)2.28396421
107positive regulation of synaptic transmission (GO:0050806)2.26470611
108lipid translocation (GO:0034204)2.26040714
109phospholipid translocation (GO:0045332)2.26040714
110dendrite morphogenesis (GO:0048813)2.25969174
111positive regulation of neurotransmitter transport (GO:0051590)2.24828131
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.24529036
113learning (GO:0007612)2.24170790
114branching involved in labyrinthine layer morphogenesis (GO:0060670)2.24032484
115L-amino acid import (GO:0043092)2.23645787
116positive regulation of chemokine biosynthetic process (GO:0045080)2.23608796
117regulation of neurotransmitter transport (GO:0051588)2.23601632
118regulation of synaptic transmission, GABAergic (GO:0032228)2.23505983
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.23213043
120axonal fasciculation (GO:0007413)2.22675716
121detection of molecule of bacterial origin (GO:0032490)2.21223891
122positive regulation of p38MAPK cascade (GO:1900745)2.20610875
123regulation of neuron projection regeneration (GO:0070570)2.20548224
124regulation of axon regeneration (GO:0048679)2.20548224
125membrane assembly (GO:0071709)2.20406907
126regulation of vesicle fusion (GO:0031338)2.20181236
127neuromuscular process controlling balance (GO:0050885)2.19450867
128macrophage activation involved in immune response (GO:0002281)2.18566610
129response to manganese ion (GO:0010042)2.17429265
130cytoskeletal anchoring at plasma membrane (GO:0007016)2.17090767
131JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.16872722
132negative regulation of NF-kappaB import into nucleus (GO:0042347)2.15517978
133positive regulation of toll-like receptor signaling pathway (GO:0034123)2.14948485
134sarcoplasmic reticulum calcium ion transport (GO:0070296)2.14868867
135dendritic spine organization (GO:0097061)2.14730753
136regulation of T-helper cell differentiation (GO:0045622)2.14097196
137regulation of T-helper 1 cell differentiation (GO:0045625)2.13862865
138negative regulation of vascular permeability (GO:0043116)2.13847492
139neuron remodeling (GO:0016322)2.13578346
140regulation of nitric oxide biosynthetic process (GO:0045428)2.13444483
141response to host immune response (GO:0052572)2.13067637
142response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.13067637
143striatum development (GO:0021756)2.11608905
144T-helper 1 type immune response (GO:0042088)2.11410631
145positive regulation of macrophage cytokine production (GO:0060907)2.09911548
146central nervous system projection neuron axonogenesis (GO:0021952)2.09153833
147regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.08190706
148regulation of interferon-beta biosynthetic process (GO:0045357)2.07526529
149sodium ion export (GO:0071436)2.07493878
150positive regulation of interferon-alpha production (GO:0032727)2.06921931
151* negative regulation of dendrite morphogenesis (GO:0050774)2.06407590
152cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.06002600
153negative regulation of erythrocyte differentiation (GO:0045647)2.05271396
154* negative regulation of dendrite development (GO:2000171)2.03783519
155positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.02219669
156macrophage activation (GO:0042116)2.01861655
157regulation of vitamin metabolic process (GO:0030656)2.01573869
158regulation of chronic inflammatory response (GO:0002676)2.00208924
159negative regulation of lipid storage (GO:0010888)2.00128922
160positive regulation of T-helper cell differentiation (GO:0045624)1.99777146
161regulation of amino acid transport (GO:0051955)1.98686886
162regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)1.98025956
163ovulation (GO:0030728)1.96977490
164amino acid import (GO:0043090)1.95509696
165regulation of membrane protein ectodomain proteolysis (GO:0051043)1.94640601
166protein K11-linked deubiquitination (GO:0035871)1.93954635
167cellular response to epinephrine stimulus (GO:0071872)1.93633014
168platelet-derived growth factor receptor signaling pathway (GO:0048008)1.92803611
169regulation of nitric-oxide synthase biosynthetic process (GO:0051769)1.92453445
170endothelium development (GO:0003158)1.92122478
171positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.91823267

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.72453771
2EZH2_22144423_ChIP-Seq_EOC_Human3.35572970
3GATA1_22025678_ChIP-Seq_K562_Human2.84308769
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.77839907
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30053288
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20296777
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14529495
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07123974
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01620513
10EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87517034
11RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87517034
12* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86827851
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86643942
14* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85528870
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84876752
16DROSHA_22980978_ChIP-Seq_HELA_Human1.82822687
17* SMAD4_21799915_ChIP-Seq_A2780_Human1.82675031
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81422758
19MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77256287
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76072523
21AR_21572438_ChIP-Seq_LNCaP_Human1.73653494
22* P300_19829295_ChIP-Seq_ESCs_Human1.73106771
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73095216
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73049760
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.69292627
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69226638
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.68699874
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.67448592
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.63241883
30TAF15_26573619_Chip-Seq_HEK293_Human1.61017681
31* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60982732
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60104428
33* REST_21632747_ChIP-Seq_MESCs_Mouse1.59285698
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57527699
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54875900
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53728249
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51332883
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51272362
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.51021662
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50416015
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.49383388
42* RARB_27405468_Chip-Seq_BRAIN_Mouse1.48047427
43SCL_19346495_ChIP-Seq_HPC-7_Human1.47869170
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47856913
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.46337420
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.46100138
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.45489610
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.44972306
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44821881
50* VDR_24787735_ChIP-Seq_THP-1_Human1.44484655
51GATA1_19941826_ChIP-Seq_K562_Human1.43969389
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42720261
53* STAT3_23295773_ChIP-Seq_U87_Human1.42642812
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42180069
55STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42100078
56IGF1R_20145208_ChIP-Seq_DFB_Human1.41070148
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40005707
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39891816
59FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38283841
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37009634
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.37002601
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.35104337
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.34549835
64* GATA2_21666600_ChIP-Seq_HMVEC_Human1.33744523
65* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32610872
66SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32266670
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31901632
68* AR_25329375_ChIP-Seq_VCAP_Human1.30221780
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.29573518
70AHR_22903824_ChIP-Seq_MCF-7_Human1.29555084
71* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26980609
72* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26608725
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.26440159
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26401901
75TP53_16413492_ChIP-PET_HCT116_Human1.25575111
76* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25269159
77* TCF4_23295773_ChIP-Seq_U87_Human1.25197743
78* NANOG_18555785_Chip-Seq_ESCs_Mouse1.24713337
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.24679649
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24223642
81* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23195275
82KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.22897074
83IRF8_22096565_ChIP-ChIP_GC-B_Human1.21591484
84MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21475859
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21186124
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20876903
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.18851624
88* TP53_18474530_ChIP-ChIP_U2OS_Human1.17512950
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16459721
90* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16178393
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15500716
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15140329
93RXR_22108803_ChIP-Seq_LS180_Human1.14926839
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13881102
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13881102
96* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13603922
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12559271
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11219519
99* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10313959
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.10253232
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10101404
102* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09817985
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09424705
104PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09353313
105FLI1_27457419_Chip-Seq_LIVER_Mouse1.09229729
106PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08878243
107ER_23166858_ChIP-Seq_MCF-7_Human1.08417716
108* P53_22387025_ChIP-Seq_ESCs_Mouse1.08287159
109* GATA2_19941826_ChIP-Seq_K562_Human1.07528535
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07516313
111AR_19668381_ChIP-Seq_PC3_Human1.07298313
112P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07007950
113GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06412963
114NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06314202
115* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05571396
116* RUNX2_22187159_ChIP-Seq_PCA_Human1.05464801
117REST_18959480_ChIP-ChIP_MESCs_Mouse1.05075539
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04353166
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04353166
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03973178
121* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03187997
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02460742
123STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01778747
124PRDM14_20953172_ChIP-Seq_ESCs_Human1.01775699
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.00440098
126CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00376181
127FUS_26573619_Chip-Seq_HEK293_Human1.00331304
128SMAD3_21741376_ChIP-Seq_HESCs_Human0.99735380
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99063021
130JUN_21703547_ChIP-Seq_K562_Human0.98411808
131SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98255477
132* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97647495
133TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97492176
134SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97242484
135* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96405198

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.52420053
2MP0005171_absent_coat_pigmentation4.99466938
3MP0003880_abnormal_central_pattern4.02636797
4MP0000569_abnormal_digit_pigmentation4.02493183
5MP0003656_abnormal_erythrocyte_physiolo3.78970365
6MP0003635_abnormal_synaptic_transmissio3.20429966
7MP0000372_irregular_coat_pigmentation3.13665792
8MP0009046_muscle_twitch2.92386582
9MP0009745_abnormal_behavioral_response2.86611123
10MP0002063_abnormal_learning/memory/cond2.83166390
11MP0004147_increased_porphyrin_level2.63318258
12MP0002064_seizures2.52766553
13MP0004270_analgesia2.41578723
14MP0001501_abnormal_sleep_pattern2.33694674
15MP0003300_gastrointestinal_ulcer2.32273785
16MP0002572_abnormal_emotion/affect_behav2.22757967
17MP0002822_catalepsy2.15958113
18MP0004510_myositis2.14221595
19MP0000015_abnormal_ear_pigmentation2.12565994
20MP0001968_abnormal_touch/_nociception2.10618367
21MP0008004_abnormal_stomach_pH2.09446797
22MP0003787_abnormal_imprinting2.07870801
23MP0001486_abnormal_startle_reflex2.00672242
24MP0009780_abnormal_chondrocyte_physiolo1.95951062
25MP0009278_abnormal_bone_marrow1.85496620
26MP0002735_abnormal_chemical_nociception1.85489836
27MP0002734_abnormal_mechanical_nocicepti1.83093607
28MP0002272_abnormal_nervous_system1.82869321
29MP0009764_decreased_sensitivity_to1.78633278
30MP0002736_abnormal_nociception_after1.73912588
31MP0003136_yellow_coat_color1.70596818
32MP0005646_abnormal_pituitary_gland1.70570681
33MP0004858_abnormal_nervous_system1.70243040
34MP0006054_spinal_hemorrhage1.66738380
35MP0001440_abnormal_grooming_behavior1.66471217
36MP0010352_gastrointestinal_tract_polyps1.64082984
37MP0002138_abnormal_hepatobiliary_system1.60898399
38* MP0001545_abnormal_hematopoietic_system1.59830394
39* MP0005397_hematopoietic_system_phenotyp1.59830394
40MP0000371_diluted_coat_color1.59190781
41MP0005451_abnormal_body_composition1.52768054
42MP0003075_altered_response_to1.48887212
43MP0005386_behavior/neurological_phenoty1.48322060
44MP0004924_abnormal_behavior1.48322060
45MP0002067_abnormal_sensory_capabilities1.47404538
46MP0005167_abnormal_blood-brain_barrier1.47364098
47MP0005423_abnormal_somatic_nervous1.46578467
48MP0003045_fibrosis1.44350821
49MP0003436_decreased_susceptibility_to1.37102329
50MP0008057_abnormal_DNA_replication1.37031537
51MP0001984_abnormal_olfaction1.36525936
52MP0000778_abnormal_nervous_system1.36436083
53MP0005645_abnormal_hypothalamus_physiol1.35912699
54MP0001188_hyperpigmentation1.30468618
55MP0003303_peritoneal_inflammation1.28558250
56MP0003329_amyloid_beta_deposits1.26342570
57MP0000604_amyloidosis1.23535253
58MP0004130_abnormal_muscle_cell1.23037455
59MP0001970_abnormal_pain_threshold1.22519086
60MP0004811_abnormal_neuron_physiology1.21309906
61* MP0004808_abnormal_hematopoietic_stem1.20602168
62MP0008569_lethality_at_weaning1.17245163
63MP0002148_abnormal_hypersensitivity_rea1.16769900
64MP0005408_hypopigmentation1.14830790
65MP0002557_abnormal_social/conspecific_i1.12774554
66MP0010368_abnormal_lymphatic_system1.11683539
67MP0003633_abnormal_nervous_system1.09987863
68MP0002184_abnormal_innervation1.09234155
69MP0005595_abnormal_vascular_smooth1.08858057
70MP0002009_preneoplasia1.08505486
71MP0003634_abnormal_glial_cell1.06522882
72MP0005076_abnormal_cell_differentiation1.06278544
73MP0005174_abnormal_tail_pigmentation1.04411782
74MP0001177_atelectasis1.04360930
75MP0002733_abnormal_thermal_nociception1.04330616
76MP0003172_abnormal_lysosome_physiology1.03407110
77MP0003195_calcinosis1.03077547
78MP0001835_abnormal_antigen_presentation1.01966201
79MP0003631_nervous_system_phenotype1.01742178
80MP0009785_altered_susceptibility_to1.01175630
81MP0003690_abnormal_glial_cell0.96902113
82MP0003828_pulmonary_edema0.96264546
83MP0005623_abnormal_meninges_morphology0.95123784
84MP0001502_abnormal_circadian_rhythm0.94107190
85MP0003191_abnormal_cellular_cholesterol0.93042623
86MP0005409_darkened_coat_color0.92821579
87MP0005647_abnormal_sex_gland0.91895525
88MP0005187_abnormal_penis_morphology0.91804770
89MP0000955_abnormal_spinal_cord0.91706986
90MP0002095_abnormal_skin_pigmentation0.91646842
91MP0004484_altered_response_of0.91124155
92MP0001851_eye_inflammation0.90534516
93MP0001879_abnormal_lymphatic_vessel0.89623714
94MP0002066_abnormal_motor_capabilities/c0.88858671
95MP0004947_skin_inflammation0.87145300
96MP0002877_abnormal_melanocyte_morpholog0.86193888
97MP0002882_abnormal_neuron_morphology0.82996350
98MP0005025_abnormal_response_to0.82479307
99MP0002075_abnormal_coat/hair_pigmentati0.81963012
100MP0003646_muscle_fatigue0.81347867
101MP0003890_abnormal_embryonic-extraembry0.81238559
102MP0008874_decreased_physiological_sensi0.81111870
103MP0002139_abnormal_hepatobiliary_system0.80622272
104* MP0003091_abnormal_cell_migration0.80420155
105MP0003879_abnormal_hair_cell0.79827270
106MP0003950_abnormal_plasma_membrane0.78039848
107MP0003183_abnormal_peptide_metabolism0.77556189
108MP0003448_altered_tumor_morphology0.77244563
109MP0003221_abnormal_cardiomyocyte_apopto0.76716066
110MP0003632_abnormal_nervous_system0.76383503
111MP0001533_abnormal_skeleton_physiology0.76098907
112MP0010386_abnormal_urinary_bladder0.75951333
113MP0002419_abnormal_innate_immunity0.75679527
114MP0002332_abnormal_exercise_endurance0.75528668
115MP0003453_abnormal_keratinocyte_physiol0.75167894
116MP0005310_abnormal_salivary_gland0.73032356
117MP0005165_increased_susceptibility_to0.73005005
118MP0009765_abnormal_xenobiotic_induced0.71875044
119MP0001324_abnormal_eye_pigmentation0.70683145
120MP0003724_increased_susceptibility_to0.70168478
121MP0002998_abnormal_bone_remodeling0.69934736
122MP0004885_abnormal_endolymph0.69077249
123MP0002090_abnormal_vision0.68772172
124MP0004381_abnormal_hair_follicle0.68593640
125MP0004142_abnormal_muscle_tone0.68585894
126MP0000920_abnormal_myelination0.68285017
127MP0005535_abnormal_body_temperature0.68209604
128MP0001186_pigmentation_phenotype0.67751772
129MP0002638_abnormal_pupillary_reflex0.65063046
130MP0005166_decreased_susceptibility_to0.65005950
131MP0004215_abnormal_myocardial_fiber0.64324951
132MP0005164_abnormal_response_to0.64142656
133MP0002133_abnormal_respiratory_system0.64090971
134MP0005388_respiratory_system_phenotype0.64090971
135MP0004085_abnormal_heartbeat0.63660901
136MP0003122_maternal_imprinting0.63530571
137MP0001790_abnormal_immune_system0.62014834
138MP0005387_immune_system_phenotype0.62014834
139MP0006082_CNS_inflammation0.61890288
140MP0004742_abnormal_vestibular_system0.61519459
141MP0005000_abnormal_immune_tolerance0.58804432

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.58533301
2Febrile seizures (HP:0002373)4.69998108
3Blue irides (HP:0000635)4.52931738
4Myokymia (HP:0002411)4.36535529
5Focal seizures (HP:0007359)4.32900342
6Epileptic encephalopathy (HP:0200134)4.09277825
7Progressive cerebellar ataxia (HP:0002073)3.68072055
8Atonic seizures (HP:0010819)3.61097573
9Generalized hypopigmentation of hair (HP:0011358)3.11153010
10Abnormality of the nasal septum (HP:0000419)3.10412523
11Gaze-evoked nystagmus (HP:0000640)3.10135108
12Visual hallucinations (HP:0002367)3.09411124
13Ocular albinism (HP:0001107)3.07844460
14Disinhibition (HP:0000734)3.02505415
15Iris hypopigmentation (HP:0007730)2.98359584
16Hyperventilation (HP:0002883)2.95257596
17Absence seizures (HP:0002121)2.92451493
18Hematochezia (HP:0002573)2.91681887
19Generalized tonic-clonic seizures (HP:0002069)2.91618255
20Generalized hypopigmentation (HP:0007513)2.89306144
21Neurofibrillary tangles (HP:0002185)2.85445186
22Broad-based gait (HP:0002136)2.84181066
23Genetic anticipation (HP:0003743)2.83303638
24Aplasia/Hypoplasia of the macula (HP:0008059)2.80479319
25Urinary bladder sphincter dysfunction (HP:0002839)2.76191547
26Poikilocytosis (HP:0004447)2.71978006
27Dialeptic seizures (HP:0011146)2.70059123
28Abnormal hair whorl (HP:0010721)2.68497056
29Increased IgM level (HP:0003496)2.64051957
30Action tremor (HP:0002345)2.62845914
31Prostate neoplasm (HP:0100787)2.59740417
32Impaired vibration sensation in the lower limbs (HP:0002166)2.57447689
33Lower limb amyotrophy (HP:0007210)2.56798170
34Aplasia/Hypoplasia of the fovea (HP:0008060)2.56409894
35Hypoplasia of the fovea (HP:0007750)2.56409894
36Spastic gait (HP:0002064)2.56121781
37Drooling (HP:0002307)2.55939608
38Excessive salivation (HP:0003781)2.55939608
39Abnormality of the heme biosynthetic pathway (HP:0010472)2.54609678
40Heterochromia iridis (HP:0001100)2.52943644
41Optic neuritis (HP:0100653)2.45058915
42Retrobulbar optic neuritis (HP:0100654)2.45058915
43Aplasia/Hypoplasia affecting the retina (HP:0008061)2.44987398
44Macroorchidism (HP:0000053)2.41955162
45Cerebral inclusion bodies (HP:0100314)2.36951117
46Congenital sensorineural hearing impairment (HP:0008527)2.35502591
47White forelock (HP:0002211)2.29282075
48Dysmetria (HP:0001310)2.28465744
49Hemiplegia (HP:0002301)2.28336004
50Autoimmune thrombocytopenia (HP:0001973)2.28169074
51Keratoconjunctivitis (HP:0001096)2.27338942
52Hypochromic microcytic anemia (HP:0004840)2.26823207
53Absent speech (HP:0001344)2.24490723
54Thick nail (HP:0001805)2.23348687
55Abnormality of the fovea (HP:0000493)2.21775382
56Amblyopia (HP:0000646)2.20585719
57Abnormality of salivation (HP:0100755)2.20337091
58Protruding tongue (HP:0010808)2.16939056
59Poor eye contact (HP:0000817)2.15486062
60Abnormality of the fingertips (HP:0001211)2.15024130
61Abnormality of the periventricular white matter (HP:0002518)2.13866925
62Subacute progressive viral hepatitis (HP:0006572)2.13821212
63Fair hair (HP:0002286)2.10252155
64Dysdiadochokinesis (HP:0002075)2.08510951
65Absent frontal sinuses (HP:0002688)2.08298447
66Fetal akinesia sequence (HP:0001989)2.05504997
67Decreased motor nerve conduction velocity (HP:0003431)2.05490080
68Recurrent abscess formation (HP:0002722)2.05395550
69Distal lower limb amyotrophy (HP:0008944)2.04139817
70Mediastinal lymphadenopathy (HP:0100721)2.03463563
71Thyroid carcinoma (HP:0002890)2.01815827
72Abnormality of the vasculature of the conjunctiva (HP:0008054)2.01172957
73Apathy (HP:0000741)1.99282826
74Stomatitis (HP:0010280)1.98805929
75Postural instability (HP:0002172)1.98692884
76Myositis (HP:0100614)1.98349964
77Stomach cancer (HP:0012126)1.98046412
78Hip dysplasia (HP:0001385)1.95219464
79Lower limb muscle weakness (HP:0007340)1.94849458
80Truncal ataxia (HP:0002078)1.94095318
81Thickened helices (HP:0000391)1.93985365
82Widely spaced teeth (HP:0000687)1.92891547
83Eczematoid dermatitis (HP:0000976)1.92623266
84Incomplete penetrance (HP:0003829)1.91791545
85Abnormal social behavior (HP:0012433)1.90459169
86Impaired social interactions (HP:0000735)1.90459169
87Recurrent bacterial skin infections (HP:0005406)1.89677680
88Difficulty running (HP:0009046)1.89213721
89Hypoplasia of the iris (HP:0007676)1.88290555
90Spontaneous hematomas (HP:0007420)1.87823464
91Abnormality of incisor morphology (HP:0011063)1.87438713
92Transitional cell carcinoma of the bladder (HP:0006740)1.86336530
93Curly hair (HP:0002212)1.85606383
94Patchy hypopigmentation of hair (HP:0011365)1.84924834
95Amyotrophic lateral sclerosis (HP:0007354)1.84449992
96Tetraparesis (HP:0002273)1.84002307
97Epileptiform EEG discharges (HP:0011182)1.82857483
98Supranuclear gaze palsy (HP:0000605)1.80980700
99Agnosia (HP:0010524)1.80656254
100Orchitis (HP:0100796)1.80276669
101Deeply set eye (HP:0000490)1.80218270
102Impaired vibratory sensation (HP:0002495)1.80160625
103Papilledema (HP:0001085)1.79631402
104Bladder neoplasm (HP:0009725)1.79385463
105Bladder carcinoma (HP:0002862)1.79385463
106Microcytic anemia (HP:0001935)1.78661804
107Cubitus valgus (HP:0002967)1.77651223
108Stereotypic behavior (HP:0000733)1.77485067
109Pulmonic stenosis (HP:0001642)1.77253081
110Long nose (HP:0003189)1.77178035
111Impaired smooth pursuit (HP:0007772)1.74425969
112Urinary urgency (HP:0000012)1.74289144
113Progressive sensorineural hearing impairment (HP:0000408)1.71677617
114Palpebral edema (HP:0100540)1.71091548
115Diplopia (HP:0000651)1.70780794
116Abnormality of binocular vision (HP:0011514)1.70780794
117Neoplasm of the tracheobronchial system (HP:0100552)1.69470008
118Conjunctival telangiectasia (HP:0000524)1.69311330
119Anxiety (HP:0000739)1.68521334
120Overgrowth (HP:0001548)1.67586077
121Slow saccadic eye movements (HP:0000514)1.67390913
122Dysmetric saccades (HP:0000641)1.67262771
123Abnormal eating behavior (HP:0100738)1.66896674
124Neuronal loss in central nervous system (HP:0002529)1.66747262
125Obstructive sleep apnea (HP:0002870)1.66622027
126Diminished motivation (HP:0000745)1.65868507
127Onion bulb formation (HP:0003383)1.65526102
128Abnormality of the corticospinal tract (HP:0002492)1.65197204
129Scanning speech (HP:0002168)1.64686589
130Submucous cleft hard palate (HP:0000176)1.64023185
131Progressive inability to walk (HP:0002505)1.63855452
132Megalencephaly (HP:0001355)1.63449312
133EEG with generalized epileptiform discharges (HP:0011198)1.63203783
134Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.62844423
135Hemiparesis (HP:0001269)1.62667395
136Pheochromocytoma (HP:0002666)1.62247825
137Inappropriate behavior (HP:0000719)1.62235909
138Aqueductal stenosis (HP:0002410)1.62020402
139Abnormality of glycosphingolipid metabolism (HP:0004343)1.61569627
140Abnormality of glycolipid metabolism (HP:0010969)1.61569627
141Abnormality of liposaccharide metabolism (HP:0010968)1.61569627
142Depression (HP:0000716)1.58503651
143Heterotopia (HP:0002282)1.58446658
144Mutism (HP:0002300)1.57928810
145Keratoconjunctivitis sicca (HP:0001097)1.57829256
146Atrial fibrillation (HP:0005110)1.57161704
147Narrow nasal bridge (HP:0000446)1.56458312
148Papillary thyroid carcinoma (HP:0002895)1.56064311
149Ankle clonus (HP:0011448)1.55570110
150Bilateral sensorineural hearing impairment (HP:0008619)1.54986716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.78754216
2NTRK33.52686393
3RIPK43.37605128
4MAP3K142.70689012
5CASK2.61446460
6MAP3K92.57511426
7MAP3K132.39016354
8PRPF4B2.35012779
9MAP3K42.31201655
10DAPK22.30195387
11BMPR22.29362755
12PLK22.28815822
13MAP2K72.06262214
14MST1R2.05742723
15SGK21.81851712
16SIK31.75364714
17MINK11.68412782
18MAP3K121.66832676
19TAOK21.61786486
20LATS21.58213887
21DAPK11.55841588
22CAMK1D1.54504570
23IRAK11.52765879
24MATK1.49673459
25SGK31.47192366
26MARK11.46740721
27BRD41.36758961
28KSR11.34767939
29AKT31.33656103
30NTRK21.33446561
31ACVR1B1.28780570
32SGK2231.26195101
33SGK4941.26195101
34CAMKK11.24810673
35MAP2K31.24793989
36TAOK11.23978884
37MAP2K41.17829328
38DMPK1.12885254
39SIK21.12681787
40CLK11.12137482
41ERBB31.11685371
42SGK11.08839226
43JAK11.08571376
44PAK61.06708589
45CDK51.05994575
46BMX1.05289734
47TIE11.05228713
48MARK31.03789330
49PTK2B0.99814713
50TXK0.98849773
51MAPK130.98351191
52FGR0.97677409
53NEK60.95376032
54FES0.93339892
55IRAK20.93144057
56JAK20.92960650
57NTRK10.90724105
58PRKCE0.90024795
59KSR20.89806373
60PRKD30.89154123
61EPHA30.88199839
62RIPK10.85773637
63PDGFRB0.84030672
64INSRR0.83710569
65IKBKE0.83702038
66PRKCH0.82331687
67CAMK2A0.81963402
68GRK50.81688799
69BCR0.81052673
70ARAF0.80044175
71TGFBR20.79951802
72TNIK0.76587607
73PDGFRA0.76186585
74MAP3K10.73987221
75STK380.70432301
76MARK20.70296862
77FGFR30.70027632
78PKN10.69023547
79MAP3K60.68653426
80CSK0.66769363
81LATS10.65286963
82CAMKK20.65042941
83PRKCG0.65013540
84NLK0.64687297
85DYRK1A0.63680109
86MAP3K30.63329052
87UHMK10.63086591
88PDK10.62147129
89PIM10.60345724
90DDR20.59377859
91BLK0.58900415
92MKNK20.58256368
93MOS0.57861699
94STK390.56342583
95CAMK2B0.56003548
96IKBKB0.55999566
97TBK10.55922308
98MAP3K50.55272595
99FRK0.54545472
100CAMK40.54080144
101MKNK10.53581593
102PDPK10.53534351
103CHUK0.52026688
104FER0.51570963
105MET0.51447515
106MAP3K110.50322394
107GRK70.50161994
108PINK10.50139675
109CDK60.50128616
110STK240.50033534
111EGFR0.49927225
112TYRO30.49745691
113SYK0.49629367
114IRAK30.46194731
115RET0.45222270
116DYRK30.45088444
117RAF10.44648636
118PBK0.43367287
119TRPM70.42039495
120JAK30.41988024
121STK110.41653613
122MAP3K20.41606872
123RPS6KA30.41411122
124MAPK70.41204274
125YES10.40909191
126WNK10.39945000
127PRKCZ0.39136043
128TYK20.38845028
129FYN0.38267247
130TNK20.37707187
131NUAK10.37220433
132IRAK40.36026453
133CAMK10.35954301
134MAPK100.33728677
135PAK30.33406402
136CAMK1G0.31691771
137HCK0.31287989

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.57304193
2Olfactory transduction_Homo sapiens_hsa047402.33059034
3Synaptic vesicle cycle_Homo sapiens_hsa047212.13675572
4Circadian entrainment_Homo sapiens_hsa047132.02182212
5Morphine addiction_Homo sapiens_hsa050321.98587029
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.92611811
7Long-term potentiation_Homo sapiens_hsa047201.89222414
8Glutamatergic synapse_Homo sapiens_hsa047241.84341169
9GABAergic synapse_Homo sapiens_hsa047271.77297809
10Type I diabetes mellitus_Homo sapiens_hsa049401.63009760
11Amphetamine addiction_Homo sapiens_hsa050311.62928231
12Salivary secretion_Homo sapiens_hsa049701.58822770
13Allograft rejection_Homo sapiens_hsa053301.51570022
14African trypanosomiasis_Homo sapiens_hsa051431.47218211
15Cholinergic synapse_Homo sapiens_hsa047251.47070888
16Dopaminergic synapse_Homo sapiens_hsa047281.42588416
17Graft-versus-host disease_Homo sapiens_hsa053321.36147167
18Type II diabetes mellitus_Homo sapiens_hsa049301.32971319
19Calcium signaling pathway_Homo sapiens_hsa040201.30756940
20Rheumatoid arthritis_Homo sapiens_hsa053231.29693984
21Renin secretion_Homo sapiens_hsa049241.28936589
22Gastric acid secretion_Homo sapiens_hsa049711.28201195
23Collecting duct acid secretion_Homo sapiens_hsa049661.26357503
24Oxytocin signaling pathway_Homo sapiens_hsa049211.25467251
25Serotonergic synapse_Homo sapiens_hsa047261.24275572
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23931405
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23714392
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23601192
29Insulin secretion_Homo sapiens_hsa049111.22638223
30Long-term depression_Homo sapiens_hsa047301.20534147
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20464155
32Taste transduction_Homo sapiens_hsa047421.19314837
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13072726
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12128302
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11358767
36cAMP signaling pathway_Homo sapiens_hsa040241.08198647
37Chronic myeloid leukemia_Homo sapiens_hsa052201.08163056
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07653984
39GnRH signaling pathway_Homo sapiens_hsa049121.05329475
40B cell receptor signaling pathway_Homo sapiens_hsa046621.05166728
41TNF signaling pathway_Homo sapiens_hsa046681.04757492
42Chemokine signaling pathway_Homo sapiens_hsa040621.04016538
43Dorso-ventral axis formation_Homo sapiens_hsa043201.03797882
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.03521239
45ErbB signaling pathway_Homo sapiens_hsa040121.02411135
46Glioma_Homo sapiens_hsa052141.01124392
47Legionellosis_Homo sapiens_hsa051341.00933964
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00662716
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00002795
50Cocaine addiction_Homo sapiens_hsa050300.98971322
51Hepatitis C_Homo sapiens_hsa051600.98565693
52FoxO signaling pathway_Homo sapiens_hsa040680.96773689
53Melanogenesis_Homo sapiens_hsa049160.96717804
54Osteoclast differentiation_Homo sapiens_hsa043800.94923571
55Renal cell carcinoma_Homo sapiens_hsa052110.94658364
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94349281
57Leishmaniasis_Homo sapiens_hsa051400.94204855
58Hepatitis B_Homo sapiens_hsa051610.92179009
59Dilated cardiomyopathy_Homo sapiens_hsa054140.90704206
60Tuberculosis_Homo sapiens_hsa051520.90381319
61Autoimmune thyroid disease_Homo sapiens_hsa053200.89550059
62Axon guidance_Homo sapiens_hsa043600.87723197
63Platelet activation_Homo sapiens_hsa046110.87446538
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85372187
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84483776
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84196619
67Gap junction_Homo sapiens_hsa045400.83348168
68Pancreatic cancer_Homo sapiens_hsa052120.83246846
69Endometrial cancer_Homo sapiens_hsa052130.83080950
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.82339996
71Asthma_Homo sapiens_hsa053100.82027492
72Estrogen signaling pathway_Homo sapiens_hsa049150.81800589
73Acute myeloid leukemia_Homo sapiens_hsa052210.81583618
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80637238
75Staphylococcus aureus infection_Homo sapiens_hsa051500.79814319
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79219943
77Prion diseases_Homo sapiens_hsa050200.78761149
78Salmonella infection_Homo sapiens_hsa051320.78488681
79Influenza A_Homo sapiens_hsa051640.77980201
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77276943
81Pertussis_Homo sapiens_hsa051330.76491666
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.76188168
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75485784
84Malaria_Homo sapiens_hsa051440.75014252
85* MAPK signaling pathway_Homo sapiens_hsa040100.74853955
86Phagosome_Homo sapiens_hsa041450.72892420
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72734208
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.72722684
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72029674
90Non-small cell lung cancer_Homo sapiens_hsa052230.71336970
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.70064225
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69571022
93Ras signaling pathway_Homo sapiens_hsa040140.69552276
94Prolactin signaling pathway_Homo sapiens_hsa049170.66703571
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.65685878
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.65119256
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64387661
98Vibrio cholerae infection_Homo sapiens_hsa051100.63885278
99Measles_Homo sapiens_hsa051620.63843292
100Inositol phosphate metabolism_Homo sapiens_hsa005620.63175736
101Prostate cancer_Homo sapiens_hsa052150.62243126
102Insulin resistance_Homo sapiens_hsa049310.61832347
103Phototransduction_Homo sapiens_hsa047440.61461072
104MicroRNAs in cancer_Homo sapiens_hsa052060.61236497
105Adherens junction_Homo sapiens_hsa045200.60185172
106* Rap1 signaling pathway_Homo sapiens_hsa040150.60167208
107T cell receptor signaling pathway_Homo sapiens_hsa046600.60008353
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.58773902
109Choline metabolism in cancer_Homo sapiens_hsa052310.58286301
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58140656
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57061624
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56914862
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56520442
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55836857
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55290456
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55163033
117Toxoplasmosis_Homo sapiens_hsa051450.54675505
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54567079
119Lysosome_Homo sapiens_hsa041420.54432511
120VEGF signaling pathway_Homo sapiens_hsa043700.52925413
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52613317
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51880975
123Amoebiasis_Homo sapiens_hsa051460.50899818
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50063478
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48992534
126mTOR signaling pathway_Homo sapiens_hsa041500.47731217

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