RAPGEF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)9.79346178
2regulation of response to osmotic stress (GO:0047484)5.10645315
3maintenance of protein location in nucleus (GO:0051457)4.70904526
4synaptic vesicle docking involved in exocytosis (GO:0016081)4.70010996
5response to dietary excess (GO:0002021)4.53270519
6glomerular visceral epithelial cell development (GO:0072015)4.08193103
7cellular modified amino acid catabolic process (GO:0042219)4.06511024
8hormone catabolic process (GO:0042447)4.05356167
9neuronal ion channel clustering (GO:0045161)4.04620100
10proline transport (GO:0015824)4.01802077
11somite rostral/caudal axis specification (GO:0032525)4.01651657
12negative regulation of telomerase activity (GO:0051974)4.00723382
13regulation of apoptotic process involved in morphogenesis (GO:1902337)3.96826954
14positive regulation of histone deacetylation (GO:0031065)3.89429953
15glomerular basement membrane development (GO:0032836)3.72619743
16regulation of mammary gland epithelial cell proliferation (GO:0033599)3.71311664
17phagocytosis, recognition (GO:0006910)3.70630087
18glomerular epithelial cell development (GO:0072310)3.69167247
19negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.68036566
20negative regulation of epidermis development (GO:0045683)3.66742764
21biotin metabolic process (GO:0006768)3.60479316
22coenzyme catabolic process (GO:0009109)3.54997990
23phenol-containing compound catabolic process (GO:0019336)3.50626303
24cytidine metabolic process (GO:0046087)3.47618303
25cytidine catabolic process (GO:0006216)3.47618303
26cytidine deamination (GO:0009972)3.47618303
27cardiovascular system development (GO:0072358)3.47373813
28central nervous system myelination (GO:0022010)3.46801745
29axon ensheathment in central nervous system (GO:0032291)3.46801745
30histone H4-K8 acetylation (GO:0043982)3.41505190
31histone H4-K5 acetylation (GO:0043981)3.41505190
32activation of protein kinase A activity (GO:0034199)3.38883788
33glutamate secretion (GO:0014047)3.36291158
34positive regulation of protein deacetylation (GO:0090312)3.35761134
35cytoskeletal anchoring at plasma membrane (GO:0007016)3.33753501
36synaptic vesicle exocytosis (GO:0016079)3.32985438
37cellular potassium ion homeostasis (GO:0030007)3.29356154
38calcium-mediated signaling using intracellular calcium source (GO:0035584)3.27198073
39vascular endothelial growth factor signaling pathway (GO:0038084)3.24720153
40mitochondrion distribution (GO:0048311)3.24053427
41L-amino acid import (GO:0043092)3.19210657
42positive regulation of digestive system process (GO:0060456)3.18669650
43cGMP-mediated signaling (GO:0019934)3.17490875
44muscle organ morphogenesis (GO:0048644)3.15733313
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.14681746
46cell volume homeostasis (GO:0006884)3.12256046
47barbed-end actin filament capping (GO:0051016)3.12029664
48regulation of synapse maturation (GO:0090128)3.09720245
49pyrimidine ribonucleoside catabolic process (GO:0046133)3.09717976
50negative regulation of potassium ion transmembrane transport (GO:1901380)3.08619513
51notochord development (GO:0030903)3.05122319
52positive regulation of macrophage cytokine production (GO:0060907)3.00797015
53cellular response to cholesterol (GO:0071397)2.99833966
54branching involved in mammary gland duct morphogenesis (GO:0060444)2.99098551
55negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.97592793
56quinone metabolic process (GO:1901661)2.97496014
57regulation of MHC class I biosynthetic process (GO:0045343)2.96041514
58triglyceride catabolic process (GO:0019433)2.95894405
59negative regulation of smoothened signaling pathway (GO:0045879)2.92818901
60regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.92815134
61cellular response to epinephrine stimulus (GO:0071872)2.91040043
62negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.89998389
63positive regulation of synapse maturation (GO:0090129)2.89581118
64transepithelial transport (GO:0070633)2.88637608
65ovulation cycle (GO:0042698)2.85542585
66regulation of vascular permeability (GO:0043114)2.85521088
67tachykinin receptor signaling pathway (GO:0007217)2.84691237
68amino acid import (GO:0043090)2.82816995
69blood vessel maturation (GO:0001955)2.82382785
70cAMP biosynthetic process (GO:0006171)2.80866429
71regulation of ARF protein signal transduction (GO:0032012)2.80804825
72peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.80786168
73nucleoside transmembrane transport (GO:1901642)2.80681972
74regulation of synaptic vesicle exocytosis (GO:2000300)2.78005351
75acylglycerol catabolic process (GO:0046464)2.76675270
76neutral lipid catabolic process (GO:0046461)2.76675270
77hypotonic response (GO:0006971)2.76200557
78synaptic vesicle maturation (GO:0016188)2.74786756
79regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.73265940
80renal filtration (GO:0097205)2.73088281
81histone H4-K12 acetylation (GO:0043983)2.72852843
82glomerular filtration (GO:0003094)2.70600525
83organic cation transport (GO:0015695)2.70417428
84histone H4-K16 acetylation (GO:0043984)2.69819327
85surfactant homeostasis (GO:0043129)2.66867808
86positive regulation of DNA-dependent DNA replication (GO:2000105)2.66138358
87chondroitin sulfate catabolic process (GO:0030207)2.65826848
88regulation of telomere maintenance via telomerase (GO:0032210)2.65072743
89cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.64701541
90low-density lipoprotein particle clearance (GO:0034383)2.62502105
91alanine transport (GO:0032328)2.61945549
92negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.61154043
93positive regulation of receptor recycling (GO:0001921)2.60699734
94negative regulation of epidermal cell differentiation (GO:0045605)2.59773388
95interferon-gamma production (GO:0032609)2.59413217
96metanephric tubule development (GO:0072170)2.59230268
97metanephric nephron tubule development (GO:0072234)2.59230268
98cerebellar granule cell differentiation (GO:0021707)2.59151359
99negative regulation of cell cycle G2/M phase transition (GO:1902750)2.58154909
100peptidyl-tyrosine autophosphorylation (GO:0038083)2.58127819
101endothelial cell chemotaxis (GO:0035767)2.55212650
102positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.55074537
103cellular response to catecholamine stimulus (GO:0071870)2.54752081
104cellular response to monoamine stimulus (GO:0071868)2.54752081
105regulation of short-term neuronal synaptic plasticity (GO:0048172)2.54690028
106cell-substrate junction assembly (GO:0007044)2.54032653
107adherens junction assembly (GO:0034333)2.52958978
108valine metabolic process (GO:0006573)2.52917663
109cell fate commitment involved in formation of primary germ layer (GO:0060795)2.52276898
110regulation of synapse structural plasticity (GO:0051823)2.51946007
111negative regulation of amino acid transport (GO:0051956)2.51655542
112semaphorin-plexin signaling pathway (GO:0071526)2.51513097
113metanephric nephron epithelium development (GO:0072243)2.49274943
114protein targeting to plasma membrane (GO:0072661)2.49066994
115apoptotic cell clearance (GO:0043277)2.48675758
116regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.48309297
117sulfur amino acid catabolic process (GO:0000098)2.48262499
118primitive streak formation (GO:0090009)2.47933352
119negative regulation of DNA biosynthetic process (GO:2000279)2.47417080
120vitamin A metabolic process (GO:0006776)2.47333220
121cell proliferation involved in metanephros development (GO:0072203)2.47253703
122positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.46655309
123detection of calcium ion (GO:0005513)2.46476668
124metanephric epithelium development (GO:0072207)2.45810621
125epoxygenase P450 pathway (GO:0019373)2.45611667
126locomotory exploration behavior (GO:0035641)2.44739531
127potassium ion import (GO:0010107)2.44439974
128positive regulation of glucose import (GO:0046326)2.44289559
129cell-substrate adherens junction assembly (GO:0007045)2.43917530
130focal adhesion assembly (GO:0048041)2.43917530
131quaternary ammonium group transport (GO:0015697)2.42179385
132regulation of ARF GTPase activity (GO:0032312)2.41917018
133neutral amino acid transport (GO:0015804)2.41773054
134retinoic acid receptor signaling pathway (GO:0048384)2.41755755
135endothelium development (GO:0003158)2.41516629
136cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.41503727
137regulation of cilium movement (GO:0003352)2.40967526
138regulation of sequestering of triglyceride (GO:0010889)2.40615700
139NADH metabolic process (GO:0006734)2.40268657
140cellular response to sterol (GO:0036315)2.39965697
141L-serine transport (GO:0015825)2.39933835
142cell communication by electrical coupling (GO:0010644)2.38743056
143myelin maintenance (GO:0043217)2.38477874
144cell communication involved in cardiac conduction (GO:0086065)2.38443356
145nucleoside transport (GO:0015858)2.37936786
146regulation of synaptic vesicle transport (GO:1902803)2.37164054
147positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.35992150
148neuromuscular process controlling balance (GO:0050885)2.34954565
149vocalization behavior (GO:0071625)2.34803048
150sulfur compound transport (GO:0072348)2.34220800
151extracellular matrix assembly (GO:0085029)2.34177971
152regulation of neuronal synaptic plasticity (GO:0048168)2.32969360
153cellular response to osmotic stress (GO:0071470)2.32761049
154sodium ion export (GO:0071436)2.32616454
155mannose metabolic process (GO:0006013)2.32265392
156response to epinephrine (GO:0071871)2.31749760
157neurotransmitter secretion (GO:0007269)2.30917395
158maintenance of protein localization in organelle (GO:0072595)2.30337898
159positive regulation of glucose transport (GO:0010828)2.29667839
160hemidesmosome assembly (GO:0031581)2.29432829
161potassium ion homeostasis (GO:0055075)2.29289709
162peripheral nervous system axon ensheathment (GO:0032292)2.29097309
163myelination in peripheral nervous system (GO:0022011)2.29097309
164positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.28921134
165regulation of p38MAPK cascade (GO:1900744)2.27687964
166negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.26938128
167actin filament capping (GO:0051693)2.26302258
168transcytosis (GO:0045056)2.25650850
169negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.24107637
170glycerolipid catabolic process (GO:0046503)2.23425839
171cellular response to reactive nitrogen species (GO:1902170)2.22905324
172cardiac muscle contraction (GO:0060048)2.22467556
173regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.22091406
174positive regulation of protein dephosphorylation (GO:0035307)2.20594717
175insulin-like growth factor receptor signaling pathway (GO:0048009)2.19915192
176regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.19147714
177endocrine hormone secretion (GO:0060986)2.18083962
178dopamine receptor signaling pathway (GO:0007212)2.18054936
179positive regulation of dendritic spine development (GO:0060999)2.17955940
180vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.17525888
181adenosine receptor signaling pathway (GO:0001973)2.17339285
182daunorubicin metabolic process (GO:0044597)11.3295576
183polyketide metabolic process (GO:0030638)11.3295576
184doxorubicin metabolic process (GO:0044598)11.3295576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.46987285
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.19751552
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.19751552
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.19751552
5* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.96232857
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.72898434
7SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.41089833
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35562991
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.16929676
10EZH2_22144423_ChIP-Seq_EOC_Human2.05426909
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.04287105
12TP63_17297297_ChIP-ChIP_HaCaT_Human1.94002946
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89508944
14CDX2_20551321_ChIP-Seq_CACO-2_Human1.89506452
15TCF3_18692474_ChIP-Seq_MESCs_Mouse1.85910380
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79232489
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78782568
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78782568
19HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78131255
20* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76654333
21TCF3_18692474_ChIP-Seq_MEFs_Mouse1.74062262
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73112010
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.71623614
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71056560
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.71048261
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.70105254
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69749131
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.67233730
29ZFP281_27345836_Chip-Seq_ESCs_Mouse1.64116686
30* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63605832
31* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.63094377
32* KDM2B_26808549_Chip-Seq_DND41_Human1.61680308
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60320615
34* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58408363
35CLOCK_20551151_ChIP-Seq_293T_Human1.58137515
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.56634148
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56336207
38CTCF_27219007_Chip-Seq_Bcells_Human1.52281611
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51726392
40KDM2B_26808549_Chip-Seq_K562_Human1.50189080
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48111677
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45457083
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45337462
44NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.45216662
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.44573181
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42429032
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41322968
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39396391
49FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.38745728
50PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.38652315
51POU5F1_16518401_ChIP-PET_MESCs_Mouse1.37633924
52* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.35519722
53* TCF7_22412390_ChIP-Seq_EML_Mouse1.33217786
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32966978
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30631695
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30627206
57LXR_22292898_ChIP-Seq_THP-1_Human1.30176102
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28137973
59* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28073301
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27035151
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.26414362
62NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.26408280
63P68_20966046_ChIP-Seq_HELA_Human1.25190827
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24844465
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24673499
66* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22684803
67* TET1_21490601_ChIP-Seq_MESCs_Mouse1.22091565
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.22066693
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21890174
70TP53_20018659_ChIP-ChIP_R1E_Mouse1.21304194
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.21122000
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21008082
73E2F1_17053090_ChIP-ChIP_MCF-7_Human1.20412825
74NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19551421
75SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19398934
76* RING1B_27294783_Chip-Seq_NPCs_Mouse1.19389418
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.18801782
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18071726
79* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16912349
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16182966
81* CREB1_26743006_Chip-Seq_LNCaP_Human1.15181903
82NANOG_18692474_ChIP-Seq_MESCs_Mouse1.14719534
83SMC4_20622854_ChIP-Seq_HELA_Human1.14712398
84SCL_19346495_ChIP-Seq_HPC-7_Human1.14594142
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.12916142
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12547449
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11657374
88TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11242789
89SMAD3_21741376_ChIP-Seq_HESCs_Human1.10840185
90* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10236292
91IRF1_19129219_ChIP-ChIP_H3396_Human1.10183105
92TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10122547
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.09568428
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.09308470
95PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08285638
96NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08112987
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08072501
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06891087
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06381456
100TP53_22127205_ChIP-Seq_IMR90_Human1.05409561
101TP53_23651856_ChIP-Seq_MEFs_Mouse1.05095513
102RACK7_27058665_Chip-Seq_MCF-7_Human1.04790547
103SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04552358
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03896366
105JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03501139
106* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02144360
107RUNX1_27514584_Chip-Seq_MCF-7_Human1.01965328
108SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01727078
109SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01485307
110P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00700639
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00520311
112* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00486219
113EED_16625203_ChIP-ChIP_MESCs_Mouse0.99527434
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98669600
115RARB_27405468_Chip-Seq_BRAIN_Mouse0.97569931
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97020654
117CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96975366
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96365297
119WT1_19549856_ChIP-ChIP_CCG9911_Human0.96029277
120TBX20_22328084_ChIP-Seq_HEART_Mouse0.95813005
121TBX20_22080862_ChIP-Seq_HEART_Mouse0.95813005
122TET1_21451524_ChIP-Seq_MESCs_Mouse0.95764785
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95342176
124EP300_21415370_ChIP-Seq_HL-1_Mouse0.94815668
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.94364266
126TP63_22573176_ChIP-Seq_HFKS_Human0.93761113
127* GATA1_19941827_ChIP-Seq_MEL_Mouse0.92923908
128KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92532791
129* ELK3_25401928_ChIP-Seq_HUVEC_Human0.91663659
130OCT4_19829295_ChIP-Seq_ESCs_Human0.91401160
131DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91356632
132AHR_22903824_ChIP-Seq_MCF-7_Human0.90701553
133EZH2_27294783_Chip-Seq_ESCs_Mouse0.90387832
134P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89890988
135RXR_22108803_ChIP-Seq_LS180_Human0.87852754
136SUZ12_27294783_Chip-Seq_ESCs_Mouse0.87686859
137EZH2_27304074_Chip-Seq_ESCs_Mouse0.87673176
138POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86622652
139NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85901668
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85085888
141RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84988042
142STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84882781
143TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.83778949
144DROSHA_22980978_ChIP-Seq_HELA_Human0.82514972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.75938218
2MP0004858_abnormal_nervous_system3.62358361
3MP0004859_abnormal_synaptic_plasticity3.25206972
4MP0004043_abnormal_pH_regulation3.16069671
5MP0005167_abnormal_blood-brain_barrier3.10234384
6MP0003011_delayed_dark_adaptation2.85613836
7MP0005377_hearing/vestibular/ear_phenot2.79170136
8MP0003878_abnormal_ear_physiology2.79170136
9MP0004264_abnormal_extraembryonic_tissu2.70983354
10MP0010368_abnormal_lymphatic_system2.69364138
11MP0006292_abnormal_olfactory_placode2.65188707
12MP0002332_abnormal_exercise_endurance2.63090896
13MP0008961_abnormal_basal_metabolism2.61350078
14MP0004084_abnormal_cardiac_muscle2.49419880
15MP0004272_abnormal_basement_membrane2.36044127
16MP0003879_abnormal_hair_cell2.30990594
17MP0009780_abnormal_chondrocyte_physiolo2.28147835
18MP0005670_abnormal_white_adipose2.15734097
19MP0005623_abnormal_meninges_morphology2.14409538
20MP0002127_abnormal_cardiovascular_syste2.12241634
21MP0004215_abnormal_myocardial_fiber2.04947247
22MP0004270_analgesia2.02269920
23MP0001501_abnormal_sleep_pattern2.01983193
24MP0003137_abnormal_impulse_conducting2.01409754
25MP0005075_abnormal_melanosome_morpholog1.99890276
26MP0004885_abnormal_endolymph1.94514013
27MP0000003_abnormal_adipose_tissue1.84692446
28MP0000678_abnormal_parathyroid_gland1.81878224
29MP0002971_abnormal_brown_adipose1.78543609
30MP0003705_abnormal_hypodermis_morpholog1.78097025
31MP0003122_maternal_imprinting1.75468092
32MP0003635_abnormal_synaptic_transmissio1.68448067
33MP0003329_amyloid_beta_deposits1.65597133
34MP0000013_abnormal_adipose_tissue1.63745900
35MP0008569_lethality_at_weaning1.62157182
36MP0005275_abnormal_skin_tensile1.60206517
37MP0001486_abnormal_startle_reflex1.60089809
38MP0005499_abnormal_olfactory_system1.59040665
39MP0005394_taste/olfaction_phenotype1.59040665
40MP0000749_muscle_degeneration1.58190559
41MP0005257_abnormal_intraocular_pressure1.57549609
42MP0001879_abnormal_lymphatic_vessel1.54407763
43MP0001502_abnormal_circadian_rhythm1.53451289
44MP0005666_abnormal_adipose_tissue1.52862155
45MP0005409_darkened_coat_color1.51362454
46MP0002064_seizures1.50695514
47MP0008775_abnormal_heart_ventricle1.50689148
48MP0003183_abnormal_peptide_metabolism1.49471253
49MP0005503_abnormal_tendon_morphology1.43453362
50MP0003690_abnormal_glial_cell1.42169070
51MP0006138_congestive_heart_failure1.40892499
52MP0000750_abnormal_muscle_regeneration1.40237812
53MP0004036_abnormal_muscle_relaxation1.40049574
54MP0000747_muscle_weakness1.39645162
55MP0003938_abnormal_ear_development1.37107497
56MP0004510_myositis1.36585260
57MP0000681_abnormal_thyroid_gland1.34471606
58MP0002063_abnormal_learning/memory/cond1.34101697
59MP0003279_aneurysm1.32737200
60MP0005423_abnormal_somatic_nervous1.30903998
61MP0005595_abnormal_vascular_smooth1.29230125
62MP0004085_abnormal_heartbeat1.29068835
63MP0005535_abnormal_body_temperature1.28848819
64MP0003890_abnormal_embryonic-extraembry1.28326600
65MP0001849_ear_inflammation1.28309507
66MP0003880_abnormal_central_pattern1.28147999
67MP0003303_peritoneal_inflammation1.26859047
68MP0000759_abnormal_skeletal_muscle1.24741303
69MP0002933_joint_inflammation1.20952607
70MP0002653_abnormal_ependyma_morphology1.19826601
71MP0002108_abnormal_muscle_morphology1.19429010
72MP0005330_cardiomyopathy1.18973722
73MP0003283_abnormal_digestive_organ1.17575051
74MP0003191_abnormal_cellular_cholesterol1.17569881
75MP0003091_abnormal_cell_migration1.16279670
76MP0006035_abnormal_mitochondrial_morpho1.15880578
77MP0005058_abnormal_lysosome_morphology1.15215265
78MP0003828_pulmonary_edema1.14846465
79MP0002972_abnormal_cardiac_muscle1.14026332
80MP0002295_abnormal_pulmonary_circulatio1.12827680
81MP0002876_abnormal_thyroid_physiology1.12536603
82MP0002249_abnormal_larynx_morphology1.11221145
83MP0002272_abnormal_nervous_system1.11170047
84MP0005165_increased_susceptibility_to1.10111606
85MP0010030_abnormal_orbit_morphology1.08966889
86MP0001293_anophthalmia1.07602410
87MP0000343_altered_response_to1.07289855
88MP0000762_abnormal_tongue_morphology1.06490241
89MP0000767_abnormal_smooth_muscle1.02056413
90MP0009745_abnormal_behavioral_response1.01964002
91MP0002092_abnormal_eye_morphology1.01887707
92MP0000049_abnormal_middle_ear1.00864020
93MP0002932_abnormal_joint_morphology1.00513488
94MP0005332_abnormal_amino_acid0.99659895
95MP0003950_abnormal_plasma_membrane0.98388277
96MP0002925_abnormal_cardiovascular_devel0.98291834
97MP0002269_muscular_atrophy0.96346220
98MP0001958_emphysema0.95948849
99MP0009046_muscle_twitch0.95557888
100MP0008438_abnormal_cutaneous_collagen0.94775340
101MP0008874_decreased_physiological_sensi0.94360123
102MP0005620_abnormal_muscle_contractility0.93702787
103MP0002572_abnormal_emotion/affect_behav0.93559127
104MP0004133_heterotaxia0.93166457
105MP0000751_myopathy0.93009621
106MP0004087_abnormal_muscle_fiber0.92345700
107MP0001765_abnormal_ion_homeostasis0.92176488
108MP0003172_abnormal_lysosome_physiology0.91315107
109MP0010630_abnormal_cardiac_muscle0.90366579
110MP0000249_abnormal_blood_vessel0.89698978
111MP0002133_abnormal_respiratory_system0.89624033
112MP0005388_respiratory_system_phenotype0.89624033
113MP0004381_abnormal_hair_follicle0.89310117
114MP0003453_abnormal_keratinocyte_physiol0.89273148
115MP0002970_abnormal_white_adipose0.88624599
116MP0008260_abnormal_autophagy0.88004745
117MP0005166_decreased_susceptibility_to0.86942853
118MP0004484_altered_response_of0.86801025
119MP0009115_abnormal_fat_cell0.86416735
120MP0002734_abnormal_mechanical_nocicepti0.85213376
121MP0004145_abnormal_muscle_electrophysio0.85173219
122MP0000579_abnormal_nail_morphology0.84314674
123MP0005375_adipose_tissue_phenotype0.84175534
124MP0004185_abnormal_adipocyte_glucose0.82860935
125MP0001177_atelectasis0.82676963
126MP0005334_abnormal_fat_pad0.82398203
127MP0005023_abnormal_wound_healing0.82351109
128MP0003634_abnormal_glial_cell0.81918554
129MP0003935_abnormal_craniofacial_develop0.81724549
130MP0000733_abnormal_muscle_development0.81676745
131MP0003631_nervous_system_phenotype0.81210822
132MP0003724_increased_susceptibility_to0.81059139
133MP0003959_abnormal_lean_body0.79203109
134MP0005369_muscle_phenotype0.78601831
135MP0003075_altered_response_to0.78133203
136MP0009643_abnormal_urine_homeostasis0.78076409
137MP0003566_abnormal_cell_adhesion0.77808669
138MP0002733_abnormal_thermal_nociception0.77616804
139MP0000920_abnormal_myelination0.75391321
140MP0003136_yellow_coat_color0.73705418
141MP0003984_embryonic_growth_retardation0.72910795
142MP0002233_abnormal_nose_morphology0.72879895
143MP0005171_absent_coat_pigmentation0.72763620
144MP0002088_abnormal_embryonic_growth/wei0.72395115
145MP0002136_abnormal_kidney_physiology0.72355173
146MP0005385_cardiovascular_system_phenoty0.71867042
147MP0001544_abnormal_cardiovascular_syste0.71867042
148MP0008770_decreased_survivor_rate0.71800206
149MP0000428_abnormal_craniofacial_morphol0.71353325
150MP0002114_abnormal_axial_skeleton0.71302860
151MP0002909_abnormal_adrenal_gland0.70888534
152MP0001614_abnormal_blood_vessel0.70303758
153MP0001270_distended_abdomen0.69730185
154MP0003121_genomic_imprinting0.69615861
155MP0003633_abnormal_nervous_system0.68415350
156MP0003045_fibrosis0.68316467
157MP0004130_abnormal_muscle_cell0.67982414
158MP0002128_abnormal_blood_circulation0.67355096

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.80256035
2Hepatoblastoma (HP:0002884)4.58942414
3Hypochromic microcytic anemia (HP:0004840)4.11661055
4Obstructive sleep apnea (HP:0002870)4.11329691
5Increased circulating renin level (HP:0000848)4.10203164
6Difficulty running (HP:0009046)3.91296176
7Muscle fiber splitting (HP:0003555)3.90419335
8Abnormality of the lower motor neuron (HP:0002366)3.72095127
9Multiple enchondromatosis (HP:0005701)3.66936703
10Hypokalemic alkalosis (HP:0001949)3.56737215
11Hyporeflexia of lower limbs (HP:0002600)3.51693080
12Neurofibrillary tangles (HP:0002185)3.51362114
13Hyperactive renin-angiotensin system (HP:0000841)3.50152194
14Metabolic alkalosis (HP:0200114)3.48077393
15Lymphangioma (HP:0100764)3.32150483
16Partial duplication of thumb phalanx (HP:0009944)3.26250339
17Hyperaldosteronism (HP:0000859)3.22595595
18Testicular atrophy (HP:0000029)3.18492510
19Hyperventilation (HP:0002883)3.17354290
20Supranuclear gaze palsy (HP:0000605)3.15461938
21Abnormality of skeletal muscle fiber size (HP:0012084)3.12040889
22Abnormality of the salivary glands (HP:0010286)3.10058954
23Ependymoma (HP:0002888)3.08518382
24Gout (HP:0001997)3.08069642
25Increased connective tissue (HP:0009025)3.07175295
26Ankle clonus (HP:0011448)3.03608709
27Exercise-induced myalgia (HP:0003738)3.02493829
28Hyperinsulinemic hypoglycemia (HP:0000825)2.96109479
29Neoplasm of striated muscle (HP:0009728)2.95844199
30Pseudobulbar signs (HP:0002200)2.95369624
31Distal lower limb amyotrophy (HP:0008944)2.93927282
32Distal lower limb muscle weakness (HP:0009053)2.93185467
33Polyuria (HP:0000103)2.91669051
34Myokymia (HP:0002411)2.89468590
35Mesangial abnormality (HP:0001966)2.87832465
36Cerebral inclusion bodies (HP:0100314)2.87720954
37Rib fusion (HP:0000902)2.85786927
38Hypomagnesemia (HP:0002917)2.84140044
39Acanthosis nigricans (HP:0000956)2.83039516
40Bundle branch block (HP:0011710)2.80412347
41Cerebral aneurysm (HP:0004944)2.80405524
42Hyperglycinuria (HP:0003108)2.78582969
43Abnormal urine output (HP:0012590)2.77207672
44Generalized hypotonia (HP:0001290)2.76140712
45Ragged-red muscle fibers (HP:0003200)2.75972090
46Lower limb amyotrophy (HP:0007210)2.72828226
47Axonal loss (HP:0003447)2.72475794
48Neoplasm of the heart (HP:0100544)2.71822115
49Partial duplication of the phalanx of hand (HP:0009999)2.71355489
50Renal salt wasting (HP:0000127)2.71331370
51Type 1 muscle fiber predominance (HP:0003803)2.70163329
52Stridor (HP:0010307)2.68870269
53Abnormality of renin-angiotensin system (HP:0000847)2.64303008
54Centrally nucleated skeletal muscle fibers (HP:0003687)2.64134131
55Abnormal drinking behavior (HP:0030082)2.63626973
56Polydipsia (HP:0001959)2.63626973
57Abnormality of renal excretion (HP:0011036)2.60833283
58Protrusio acetabuli (HP:0003179)2.60191454
59Foot dorsiflexor weakness (HP:0009027)2.60009304
60Bronchomalacia (HP:0002780)2.59988997
61Visceral angiomatosis (HP:0100761)2.59492205
62Anomalous pulmonary venous return (HP:0010772)2.55946895
63Aplasia/Hypoplasia of the fovea (HP:0008060)2.55396083
64Hypoplasia of the fovea (HP:0007750)2.55396083
65Shallow orbits (HP:0000586)2.54136833
66Hemiparesis (HP:0001269)2.52093792
67Abnormal atrioventricular conduction (HP:0005150)2.52061846
68Oligomenorrhea (HP:0000876)2.51118991
69Abnormality of binocular vision (HP:0011514)2.51021121
70Diplopia (HP:0000651)2.51021121
71Shawl scrotum (HP:0000049)2.49470657
72Nasolacrimal duct obstruction (HP:0000579)2.48055007
73Abnormality of chloride homeostasis (HP:0011422)2.46342740
74Aortic aneurysm (HP:0004942)2.44865858
75Abnormality of the foot musculature (HP:0001436)2.43985100
76Nephroblastoma (Wilms tumor) (HP:0002667)2.43876723
77Hemangiomatosis (HP:0007461)2.43775793
78Spinal rigidity (HP:0003306)2.43289931
79Heart block (HP:0012722)2.40905155
80Abnormality of the astrocytes (HP:0100707)2.36747882
81Astrocytoma (HP:0009592)2.36747882
82Action tremor (HP:0002345)2.35823816
83Ventricular tachycardia (HP:0004756)2.34216156
84Resting tremor (HP:0002322)2.32848653
85Asymmetric septal hypertrophy (HP:0001670)2.32763352
86Nuclear cataract (HP:0100018)2.30633149
87Abnormality of the pulmonary veins (HP:0011718)2.30443263
88Sudden death (HP:0001699)2.29664752
89Atrioventricular block (HP:0001678)2.28745798
90Abnormality of chromosome segregation (HP:0002916)2.27294252
91Aplasia involving bones of the extremities (HP:0009825)2.26683953
92Aplasia involving bones of the upper limbs (HP:0009823)2.26683953
93Aplasia of the phalanges of the hand (HP:0009802)2.26683953
94Embryonal renal neoplasm (HP:0011794)2.25227551
95Exercise-induced muscle cramps (HP:0003710)2.24083655
96Difficulty climbing stairs (HP:0003551)2.23658297
97Neck muscle weakness (HP:0000467)2.22893990
98EMG: myopathic abnormalities (HP:0003458)2.21510507
99Rhabdomyosarcoma (HP:0002859)2.21314307
100Hypopigmentation of the fundus (HP:0007894)2.20878751
101Abnormal eating behavior (HP:0100738)2.15581230
102Hypertriglyceridemia (HP:0002155)2.13330269
103Polar cataract (HP:0010696)2.12278123
104Papilledema (HP:0001085)2.11248640
105Tetany (HP:0001281)2.10321312
106Abnormality of the fovea (HP:0000493)2.09433307
107Hypercortisolism (HP:0001578)2.08609924
108Abnormality of magnesium homeostasis (HP:0004921)2.07942468
109Atrial fibrillation (HP:0005110)2.06860313
110EMG: neuropathic changes (HP:0003445)2.06174974
111Ketoacidosis (HP:0001993)2.04387865
112Abnormal cartilage morphology (HP:0002763)2.04012057
113Myotonia (HP:0002486)2.03138042
114Broad face (HP:0000283)2.02260290
115Abnormality of the pubic bones (HP:0003172)2.00591167
116Annular pancreas (HP:0001734)2.00575720
117Upper limb amyotrophy (HP:0009129)2.00277416
118Distal upper limb amyotrophy (HP:0007149)2.00277416
119Bulbar palsy (HP:0001283)1.99074544
120Horizontal nystagmus (HP:0000666)1.98552293
121Prolonged QT interval (HP:0001657)1.98011915
122Sensory axonal neuropathy (HP:0003390)1.97999422
123Abnormality of glycine metabolism (HP:0010895)1.96582640
124Abnormality of serine family amino acid metabolism (HP:0010894)1.96582640
125Muscle fiber inclusion bodies (HP:0100299)1.96122514
126Focal motor seizures (HP:0011153)1.95954235
127Abnormality of the periventricular white matter (HP:0002518)1.94755399
128Primary atrial arrhythmia (HP:0001692)1.92911282
129Postural instability (HP:0002172)1.92899883
130Rectovaginal fistula (HP:0000143)1.91593103
131Rectal fistula (HP:0100590)1.91593103
132Increased variability in muscle fiber diameter (HP:0003557)1.91483138
133Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.91029239
134Mildly elevated creatine phosphokinase (HP:0008180)1.90452233
135Syncope (HP:0001279)1.90097731
136Vaginal fistula (HP:0004320)1.89984563
137Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.89931813
138Truncal ataxia (HP:0002078)1.89642734
139Focal seizures (HP:0007359)1.89376937
140Bifid tongue (HP:0010297)1.89224817
141Supraventricular arrhythmia (HP:0005115)1.87322591
142Aplasia/Hypoplasia of the macula (HP:0008059)1.86601560
143Onion bulb formation (HP:0003383)1.86553960
144Aplasia/Hypoplasia affecting the retina (HP:0008061)1.85982413
145Hemorrhage of the eye (HP:0011885)1.85837462
146Broad metatarsal (HP:0001783)1.85645534
147Bradycardia (HP:0001662)1.85433199
148Frequent falls (HP:0002359)1.84661862
149Abnormality of the nasal mucosa (HP:0000433)1.83782986
150Hypoplasia of the iris (HP:0007676)1.83725158
151Hypoalbuminemia (HP:0003073)1.83722802
152Abnormal albumin level (HP:0012116)1.83722802
153Supraventricular tachycardia (HP:0004755)1.83590248
154Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.83447126
155Large earlobe (HP:0009748)1.82882522
156Colitis (HP:0002583)1.82669513
157Dysmetria (HP:0001310)1.82617550
158Turricephaly (HP:0000262)1.81965315
159Round ear (HP:0100830)1.81163575
160Periauricular skin pits (HP:0100277)1.81010904
161Preauricular pit (HP:0004467)1.81010904
162Polygenic inheritance (HP:0010982)1.80655178
163Abnormality of the musculature of the hand (HP:0001421)1.80538310
164Supernumerary nipples (HP:0002558)1.79983203
165Intestinal fistula (HP:0100819)1.79958750
166Rapidly progressive (HP:0003678)1.79793224
167Short humerus (HP:0005792)1.79233667
168Ventricular arrhythmia (HP:0004308)1.79073744
169Right ventricular cardiomyopathy (HP:0011663)1.79047611
170Nemaline bodies (HP:0003798)1.78832876
171Aneurysm (HP:0002617)1.76236937
172Neuronal loss in central nervous system (HP:0002529)1.75422236
173Preauricular skin tag (HP:0000384)1.74912336
174Abnormality of the lacrimal duct (HP:0011481)1.74871340
175Focal segmental glomerulosclerosis (HP:0000097)1.74732278
176Cervical subluxation (HP:0003308)1.74250933
177Back pain (HP:0003418)1.73687883
178Muscle stiffness (HP:0003552)1.73636396
179Ventricular fibrillation (HP:0001663)1.72412056
180Hyperacusis (HP:0010780)1.70938588
181Rigidity (HP:0002063)1.70781831
182Sleep apnea (HP:0010535)1.70299464
183Spastic gait (HP:0002064)1.69025031
184Growth hormone excess (HP:0000845)1.67984543
185Lower limb muscle weakness (HP:0007340)1.67710286

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.31010357
2GRK53.93090726
3ERN13.64996858
4GRK13.13725656
5GRK63.10113672
6TGFBR23.07069278
7TIE12.76032418
8WNK42.64782280
9TYRO32.49890231
10WNK12.44867010
11OXSR12.40592015
12MAPK72.18868587
13ADRBK22.03302547
14SIK11.94538836
15MARK21.91400730
16DAPK21.89974409
17NTRK11.85653049
18MAP3K131.79819131
19CSF1R1.78597114
20GRK71.76008992
21STK391.72840453
22KDR1.64208470
23MATK1.59557809
24MAP3K71.53705973
25CAMK41.52030311
26UHMK11.49194905
27PAK41.47857027
28RIPK11.45675745
29TRIB31.45149386
30PHKG21.43289395
31PHKG11.43289395
32PRKG21.42348947
33WNK31.41751724
34LATS21.41631130
35RIPK41.39069640
36LMTK21.37842534
37MARK11.31075217
38ARAF1.27808968
39MAPK121.27580798
40MAP3K91.27448388
41STK101.26766988
42MAP3K61.24597627
43MOS1.23052364
44CAMKK11.22864943
45KSR21.15562222
46EPHA41.15345079
47FGFR31.15123391
48SIK21.12049511
49CDC42BPA1.10792858
50TESK11.07491489
51EEF2K1.06362934
52MUSK1.02768789
53ADRBK11.01953722
54CAMK2B0.99202884
55EPHB10.97725577
56PDGFRA0.94833129
57PRKD30.94172834
58OBSCN0.94048642
59HIPK20.93878538
60TTK0.87289025
61EPHB20.85172700
62MAP3K10.82553203
63RPS6KA20.82027995
64MAPKAPK30.81433600
65TNIK0.80797982
66STK380.79460719
67MAP3K110.77685102
68CAMK2G0.76253822
69EPHA20.75638769
70BMX0.75171421
71AKT20.74916307
72SGK20.74687482
73CDK50.73610856
74FES0.71602847
75MAP2K40.70881026
76NTRK20.68517958
77RET0.67477121
78PRPF4B0.67273258
79CSK0.64134070
80PRKD20.63752403
81MAPK100.63529369
82DDR20.62725618
83TBK10.62651761
84TTN0.61255555
85PRKD10.59906886
86ROCK10.59508870
87PDGFRB0.58970337
88CDK70.58314640
89CAMK10.57507015
90TRPM70.56132153
91PTK20.54411728
92PRKAA20.54219128
93PTK60.54191782
94PAK60.54024401
95PAK30.53884418
96MINK10.52766520
97MAPK150.52298273
98PRKCH0.51231141
99ROCK20.50949018
100PINK10.50309258
101STK110.49710613
102MST1R0.49372749
103FGFR40.49339213
104CAMK1D0.48873357
105FER0.48823318
106IGF1R0.48751056
107RPS6KL10.48184069
108RPS6KC10.48184069
109AKT30.47595792
110ZAP700.46953387
111PRKAA10.46125449
112MET0.45688442
113RPS6KA30.45353713
114JAK10.43610842
115GSK3A0.41509057
116MYLK0.40701488
117SGK2230.40666843
118SGK4940.40666843
119BCKDK0.40652620
120ALK0.40638173
121DMPK0.40411990
122PDK20.37460519
123MAP2K60.36701903
124MTOR0.36388350
125PDK30.36093569
126PDK40.36093569
127NTRK30.36071732
128SIK30.35141272
129PDK10.34735360
130SRC0.34630907
131ICK0.34310193
132SGK30.33617256
133PTK2B0.32234104
134INSR0.31964489
135TNK20.31728033
136PDPK10.29973434
137PRKACG0.29713896
138CAMK1G0.28980303
139MAPK40.28734258
140PKN10.28595227
141PRKACB0.28373351
142PRKACA0.28203045
143MARK30.26088537

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.45406713
2Vitamin B6 metabolism_Homo sapiens_hsa007503.23209780
3Fructose and mannose metabolism_Homo sapiens_hsa000512.61288152
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.34122881
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03614735
6Nitrogen metabolism_Homo sapiens_hsa009101.93563102
7Fatty acid biosynthesis_Homo sapiens_hsa000611.92132780
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85485427
9Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80568270
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.66095118
11* Long-term potentiation_Homo sapiens_hsa047201.61135244
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.58423425
13Circadian entrainment_Homo sapiens_hsa047131.57294783
14Galactose metabolism_Homo sapiens_hsa000521.55590207
15Synaptic vesicle cycle_Homo sapiens_hsa047211.54894759
16Dilated cardiomyopathy_Homo sapiens_hsa054141.50752400
17Histidine metabolism_Homo sapiens_hsa003401.47776965
18Insulin secretion_Homo sapiens_hsa049111.45032723
19GnRH signaling pathway_Homo sapiens_hsa049121.44554486
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43876708
21Propanoate metabolism_Homo sapiens_hsa006401.42009695
22PPAR signaling pathway_Homo sapiens_hsa033201.38146298
23Fatty acid metabolism_Homo sapiens_hsa012121.34728573
24Amphetamine addiction_Homo sapiens_hsa050311.31438503
25Morphine addiction_Homo sapiens_hsa050321.30920048
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28738158
27Bile secretion_Homo sapiens_hsa049761.27790140
28Arachidonic acid metabolism_Homo sapiens_hsa005901.27632168
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25426357
30Estrogen signaling pathway_Homo sapiens_hsa049151.23792724
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23640631
32* Phospholipase D signaling pathway_Homo sapiens_hsa040721.21716344
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21383485
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19329023
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18003789
36Fatty acid degradation_Homo sapiens_hsa000711.17693149
37Protein digestion and absorption_Homo sapiens_hsa049741.17476229
38Thyroid hormone synthesis_Homo sapiens_hsa049181.14818214
39Ovarian steroidogenesis_Homo sapiens_hsa049131.14201159
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13924614
41ECM-receptor interaction_Homo sapiens_hsa045121.12885462
42Phenylalanine metabolism_Homo sapiens_hsa003601.10104997
43Gastric acid secretion_Homo sapiens_hsa049711.09539086
44Cocaine addiction_Homo sapiens_hsa050301.05681791
45* Rap1 signaling pathway_Homo sapiens_hsa040151.05460009
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.05266413
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04994399
48Insulin signaling pathway_Homo sapiens_hsa049101.02745652
49GABAergic synapse_Homo sapiens_hsa047271.02289121
50Focal adhesion_Homo sapiens_hsa045101.02275087
51Calcium signaling pathway_Homo sapiens_hsa040201.02107252
52Glioma_Homo sapiens_hsa052141.01116829
53Glutamatergic synapse_Homo sapiens_hsa047241.01017615
54Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01004687
55Cholinergic synapse_Homo sapiens_hsa047251.00978883
56Salivary secretion_Homo sapiens_hsa049701.00196878
57Choline metabolism in cancer_Homo sapiens_hsa052310.98292730
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97890627
59Dopaminergic synapse_Homo sapiens_hsa047280.97674510
60Dorso-ventral axis formation_Homo sapiens_hsa043200.96576860
61Nicotine addiction_Homo sapiens_hsa050330.96256830
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95620070
63Glycerolipid metabolism_Homo sapiens_hsa005610.95049253
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93318268
65Circadian rhythm_Homo sapiens_hsa047100.92481709
66Other glycan degradation_Homo sapiens_hsa005110.91654360
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90277304
68Melanogenesis_Homo sapiens_hsa049160.89880516
69Inositol phosphate metabolism_Homo sapiens_hsa005620.89467802
70Arginine biosynthesis_Homo sapiens_hsa002200.88717266
71Carbon metabolism_Homo sapiens_hsa012000.88587500
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87246555
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86694217
74Lysine degradation_Homo sapiens_hsa003100.86347472
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.85566832
76Cardiac muscle contraction_Homo sapiens_hsa042600.85020616
77Butanoate metabolism_Homo sapiens_hsa006500.84403063
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84324433
79Prion diseases_Homo sapiens_hsa050200.82399530
80Axon guidance_Homo sapiens_hsa043600.82207724
81* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82189587
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.81482497
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.80788984
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80656669
85Glucagon signaling pathway_Homo sapiens_hsa049220.80384226
86beta-Alanine metabolism_Homo sapiens_hsa004100.79005108
87ErbB signaling pathway_Homo sapiens_hsa040120.78566043
88Mineral absorption_Homo sapiens_hsa049780.78438765
89Basal cell carcinoma_Homo sapiens_hsa052170.78084358
90Hedgehog signaling pathway_Homo sapiens_hsa043400.77444652
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.76977899
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76974837
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76968951
94Taste transduction_Homo sapiens_hsa047420.76137543
95Amoebiasis_Homo sapiens_hsa051460.74305753
96MAPK signaling pathway_Homo sapiens_hsa040100.71659685
97Notch signaling pathway_Homo sapiens_hsa043300.71290943
98Pancreatic secretion_Homo sapiens_hsa049720.70790051
99Ras signaling pathway_Homo sapiens_hsa040140.70168623
100mTOR signaling pathway_Homo sapiens_hsa041500.69502415
101Long-term depression_Homo sapiens_hsa047300.68746081
102* cAMP signaling pathway_Homo sapiens_hsa040240.68217572
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68141519
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67458790
105Tryptophan metabolism_Homo sapiens_hsa003800.67414896
106Renin secretion_Homo sapiens_hsa049240.65719876
107Arginine and proline metabolism_Homo sapiens_hsa003300.65182387
108Pathways in cancer_Homo sapiens_hsa052000.64729387
109Tight junction_Homo sapiens_hsa045300.64632885
110Endocytosis_Homo sapiens_hsa041440.64453297
111AMPK signaling pathway_Homo sapiens_hsa041520.63106066
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62439926
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61542450
114Proteoglycans in cancer_Homo sapiens_hsa052050.60468605
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59841017
116Renal cell carcinoma_Homo sapiens_hsa052110.56533988
117Pentose phosphate pathway_Homo sapiens_hsa000300.56281938
118Platelet activation_Homo sapiens_hsa046110.56221446
119Adherens junction_Homo sapiens_hsa045200.55157015
120Acute myeloid leukemia_Homo sapiens_hsa052210.54561077
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53660178
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53467760
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53125344
124Chronic myeloid leukemia_Homo sapiens_hsa052200.51609785
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51403060
126Linoleic acid metabolism_Homo sapiens_hsa005910.51281740
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50759526
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50639937
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.50554799
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50322906
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.50091370
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49705857
133Insulin resistance_Homo sapiens_hsa049310.49441031
134Oxytocin signaling pathway_Homo sapiens_hsa049210.49169542
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.48586993
136* Leukocyte transendothelial migration_Homo sapiens_hsa046700.48437975
137Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48419936
138ABC transporters_Homo sapiens_hsa020100.47922011
139Small cell lung cancer_Homo sapiens_hsa052220.47386036
140African trypanosomiasis_Homo sapiens_hsa051430.45537078
141Gap junction_Homo sapiens_hsa045400.45082829
142Sulfur relay system_Homo sapiens_hsa041220.44729686
143Renin-angiotensin system_Homo sapiens_hsa046140.44652734
144Type II diabetes mellitus_Homo sapiens_hsa049300.44327406
145Bladder cancer_Homo sapiens_hsa052190.43632032
146VEGF signaling pathway_Homo sapiens_hsa043700.41829652

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