ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	desmosome organization (GO:0002934)	7.67574392
2	establishment of skin barrier (GO:0061436)	7.06876652
3	regulation of water loss via skin (GO:0033561)	6.58467161
4	regulation of short-term neuronal synaptic plasticity (GO:0048172)	6.51023326
5	synaptic vesicle maturation (GO:0016188)	6.33430700
6	locomotory exploration behavior (GO:0035641)	6.27914308
7	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	6.17426837
8	keratinization (GO:0031424)	5.99748375
9	synaptic vesicle docking involved in exocytosis (GO:0016081)	5.87731735
10	vocalization behavior (GO:0071625)	5.84494005
11	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	5.69519529
12	glutamate secretion (GO:0014047)	5.59984076
13	synaptic vesicle exocytosis (GO:0016079)	5.49961014
14	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	5.36778803
15	regulation of glutamate receptor signaling pathway (GO:1900449)	5.34239968
16	multicellular organismal water homeostasis (GO:0050891)	5.31644306
17	regulation of synaptic vesicle exocytosis (GO:2000300)	5.08217682
18	ionotropic glutamate receptor signaling pathway (GO:0035235)	4.97298299
19	protein localization to synapse (GO:0035418)	4.85456269
20	regulation of neuronal synaptic plasticity (GO:0048168)	4.84447760
21	exploration behavior (GO:0035640)	4.83206717
22	regulation of long-term neuronal synaptic plasticity (GO:0048169)	4.69145299
23	regulation of synaptic vesicle transport (GO:1902803)	4.56802974
24	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.53307656
25	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	4.52996840
26	neuronal action potential propagation (GO:0019227)	4.47277849
27	synaptic transmission, glutamatergic (GO:0035249)	4.45565221
28	dendritic spine morphogenesis (GO:0060997)	4.44811443
29	neurotransmitter-gated ion channel clustering (GO:0072578)	4.37118400
30	water homeostasis (GO:0030104)	4.33994820
31	glutamate receptor signaling pathway (GO:0007215)	4.33146092
32	neurotransmitter secretion (GO:0007269)	4.30254504
33	cytoskeletal anchoring at plasma membrane (GO:0007016)	4.22356762
34	regulation of synapse structural plasticity (GO:0051823)	4.19593970
35	long-term memory (GO:0007616)	4.18191222
36	neuron cell-cell adhesion (GO:0007158)	4.11317966
37	positive regulation of membrane potential (GO:0045838)	4.05771611
38	layer formation in cerebral cortex (GO:0021819)	4.04266102
39	regulation of excitatory postsynaptic membrane potential (GO:0060079)	4.01556383
40	neuron-neuron synaptic transmission (GO:0007270)	3.96476061
41	positive regulation of synapse maturation (GO:0090129)	3.93033948
42	regulation of synaptic plasticity (GO:0048167)	3.92045510
43	proline transport (GO:0015824)	3.89838606
44	regulation of dendritic spine morphogenesis (GO:0061001)	3.85514118
45	cellular potassium ion homeostasis (GO:0030007)	3.84905813
46	regulation of postsynaptic membrane potential (GO:0060078)	3.77355715
47	cell communication involved in cardiac conduction (GO:0086065)	3.74901683
48	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.71189930
49	dendritic spine organization (GO:0097061)	3.67213457
50	intermediate filament organization (GO:0045109)	3.65411906
51	keratinocyte differentiation (GO:0030216)	3.65313239
52	keratinocyte proliferation (GO:0043616)	3.62217249
53	long-term synaptic potentiation (GO:0060291)	3.60301102
54	sodium ion export (GO:0071436)	3.60222171
55	synaptic vesicle endocytosis (GO:0048488)	3.55728226
56	regulation of neurotransmitter secretion (GO:0046928)	3.49992716
57	positive regulation of neurotransmitter secretion (GO:0001956)	3.49336091
58	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	3.47616412
59	postsynaptic membrane organization (GO:0001941)	3.44095764
60	gamma-aminobutyric acid transport (GO:0015812)	3.43177913
61	chemosensory behavior (GO:0007635)	3.42706414
62	regulation of vesicle fusion (GO:0031338)	3.41463551
63	peptidyl-tyrosine autophosphorylation (GO:0038083)	3.39795170
64	neurotransmitter transport (GO:0006836)	3.39076883
65	negative regulation of keratinocyte proliferation (GO:0010839)	3.38852789
66	neuromuscular process controlling balance (GO:0050885)	3.35641249
67	activation of protein kinase A activity (GO:0034199)	3.35147952
68	amino acid import (GO:0043090)	3.34856966
69	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	3.33759123
70	regulation of dendritic spine development (GO:0060998)	3.32835272
71	neuron recognition (GO:0008038)	3.29961267
72	axon ensheathment in central nervous system (GO:0032291)	3.29723649
73	central nervous system myelination (GO:0022010)	3.29723649
74	regulation of synaptic transmission, glutamatergic (GO:0051966)	3.28946829
75	cerebellar Purkinje cell differentiation (GO:0021702)	3.26934710
76	L-amino acid import (GO:0043092)	3.25468421
77	innervation (GO:0060384)	3.24680015
78	cerebellar granule cell differentiation (GO:0021707)	3.21543923
79	positive regulation of neurotransmitter transport (GO:0051590)	3.20789324
80	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.18857204
81	regulation of neurotransmitter transport (GO:0051588)	3.18120862
82	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.17776903
83	axonal fasciculation (GO:0007413)	3.17451559
84	positive regulation of synaptic transmission, GABAergic (GO:0032230)	3.17365418
85	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.13734914
86	epidermal cell differentiation (GO:0009913)	3.13598744
87	regulation of neurotransmitter levels (GO:0001505)	3.13321830
88	hemidesmosome assembly (GO:0031581)	3.13059474
89	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.12592643
90	membrane depolarization (GO:0051899)	3.12280471
91	behavioral fear response (GO:0001662)	3.12109029
92	behavioral defense response (GO:0002209)	3.12109029
93	dendrite morphogenesis (GO:0048813)	3.12079139
94	positive regulation of dendritic spine development (GO:0060999)	3.11955464
95	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.10538224
96	transmission of nerve impulse (GO:0019226)	3.10133647
97	cardiac conduction (GO:0061337)	3.09706997
98	auditory behavior (GO:0031223)	3.09599439
99	regulation of synaptic transmission (GO:0050804)	3.08752920
100	potassium ion homeostasis (GO:0055075)	3.07523734
101	positive regulation of synaptic transmission (GO:0050806)	3.06828627
102	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.06505647
103	sodium ion homeostasis (GO:0055078)	3.05674387
104	regulation of ARF protein signal transduction (GO:0032012)	3.05287171
105	learning (GO:0007612)	3.04899528
106	regulation of heart rate by cardiac conduction (GO:0086091)	3.04698662
107	presynaptic membrane assembly (GO:0097105)	3.02492982
108	cell communication by electrical coupling (GO:0010644)	3.02339490
109	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.01889796
110	long term synaptic depression (GO:0060292)	3.01726929
111	positive regulation of vesicle fusion (GO:0031340)	3.00160287
112	social behavior (GO:0035176)	3.00016366
113	intraspecies interaction between organisms (GO:0051703)	3.00016366
114	negative regulation of dendrite morphogenesis (GO:0050774)	2.99720649
115	regulation of synapse maturation (GO:0090128)	2.99445900
116	response to auditory stimulus (GO:0010996)	2.98805754
117	vesicle transport along microtubule (GO:0047496)	2.97953791
118	neuronal ion channel clustering (GO:0045161)	2.96915206
119	glycine transport (GO:0015816)	2.96358773
120	response to histamine (GO:0034776)	2.91050388
121	membrane depolarization during action potential (GO:0086010)	2.90972562
122	regulation of cholesterol homeostasis (GO:2000188)	2.90624866
123	regulation of clathrin-mediated endocytosis (GO:2000369)	2.90620324
124	cellular sodium ion homeostasis (GO:0006883)	2.90564802
125	synaptic transmission (GO:0007268)	2.89272500
126	fear response (GO:0042596)	2.89268653
127	neuromuscular process controlling posture (GO:0050884)	2.88503612
128	regulation of guanylate cyclase activity (GO:0031282)	2.87755144
129	peptide cross-linking (GO:0018149)	2.84968824
130	ventricular cardiac muscle cell action potential (GO:0086005)	2.81766849
131	epidermis development (GO:0008544)	2.79171927
132	maintenance of gastrointestinal epithelium (GO:0030277)	2.76922085
133	hair cycle (GO:0042633)	2.75752562
134	molting cycle (GO:0042303)	2.75752562
135	epithelial cell differentiation involved in prostate gland development (GO:0060742)	2.72363799
136	regulation of female receptivity (GO:0045924)	2.70139434
137	cell-cell junction maintenance (GO:0045217)	2.69935105
138	dopamine receptor signaling pathway (GO:0007212)	2.69755100
139	long-chain fatty acid biosynthetic process (GO:0042759)	2.67940945
140	potassium ion import (GO:0010107)	2.65092210
141	renal system process involved in regulation of blood volume (GO:0001977)	2.61977166
142	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.61430647
143	apical protein localization (GO:0045176)	2.53878328
144	cochlea development (GO:0090102)	2.52702633
145	positive regulation of keratinocyte differentiation (GO:0045618)	2.50539851
146	positive regulation of epidermal cell differentiation (GO:0045606)	2.50025031
147	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.47173596
148	activation of Rac GTPase activity (GO:0032863)	2.45997079
149	NADH metabolic process (GO:0006734)	2.45730125
150	regulation of voltage-gated calcium channel activity (GO:1901385)	2.45274058
151	myelin maintenance (GO:0043217)	2.41213757
152	cell migration in hindbrain (GO:0021535)	2.35949035
153	angiotensin maturation (GO:0002003)	2.35245603
154	regulation of keratinocyte differentiation (GO:0045616)	2.32569522
155	mating behavior (GO:0007617)	2.30747420
156	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	2.30312664

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	5.92821178
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.82496849
3	* ESR2_21235772_ChIP-Seq_MCF-7_Human	3.13484993
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.13241836
5	JARID2_20064375_ChIP-Seq_MESCs_Mouse	3.07533068
6	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	3.03416775
7	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.95197630
8	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.77430400
9	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.74590679
10	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.74590679
11	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.69041679
12	DROSHA_22980978_ChIP-Seq_HELA_Human	2.63565654
13	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.60525015
14	* ESR1_21235772_ChIP-Seq_MCF-7_Human	2.56861154
15	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.53248244
16	RARB_27405468_Chip-Seq_BRAIN_Mouse	2.52837425
17	REST_21632747_ChIP-Seq_MESCs_Mouse	2.52390147
18	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.50642906
19	* SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.48162089
20	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.47437703
21	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.38724166
22	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.33703293
23	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.30606547
24	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.29179462
25	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.28967809
26	* EZH2_27294783_Chip-Seq_ESCs_Mouse	2.26315584
27	LXR_22292898_ChIP-Seq_THP-1_Human	2.22579282
28	* RACK7_27058665_Chip-Seq_MCF-7_Human	2.11356443
29	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.08539801
30	* ESR1_20079471_ChIP-ChIP_T-47D_Human	2.07166930
31	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.03214980
32	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.00732622
33	AR_21572438_ChIP-Seq_LNCaP_Human	1.94360294
34	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.94341180
35	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.88923413
36	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.85881704
37	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.78257402
38	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.72009138
39	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.70149018
40	ZNF263_19887448_ChIP-Seq_K562_Human	1.70104907
41	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.60759080
42	SMC4_20622854_ChIP-Seq_HELA_Human	1.57558431
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.56061628
44	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.56004373
45	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.55587633
46	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.55251030
47	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.55052202
48	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.50957932
49	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49896261
50	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.49653316
51	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.48051792
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.45404129
53	* CREB1_26743006_Chip-Seq_LNCaP_Human	1.44827394
54	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.43317194
55	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.41444992
56	TP63_22573176_ChIP-Seq_HFKS_Human	1.41398902
57	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.40691946
58	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.39452171
59	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.38740560
60	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.33310806
61	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.32363095
62	P68_20966046_ChIP-Seq_HELA_Human	1.32085616
63	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.30767095
64	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.30384142
65	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.30320939
66	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.29657298
67	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.28684238
68	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.27577445
69	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.27170181
70	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.25812479
71	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.24489830
72	KLF5_25053715_ChIP-Seq_YYC3_Human	1.24217595
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23641457
74	AR_25329375_ChIP-Seq_VCAP_Human	1.23618355
75	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.23270001
76	* SA1_27219007_Chip-Seq_ERYTHROID_Human	1.23061667
77	* RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.21673639
78	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.21478329
79	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20925363
80	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.20800346
81	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.20481507
82	* KDM2B_26808549_Chip-Seq_K562_Human	1.17013592
83	RXR_22108803_ChIP-Seq_LS180_Human	1.16728182
84	P300_19829295_ChIP-Seq_ESCs_Human	1.16634238
85	AR_19668381_ChIP-Seq_PC3_Human	1.16588881
86	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.16399134
87	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.16028283
88	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.15850461
89	KDM2B_26808549_Chip-Seq_DND41_Human	1.15782785
90	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.15343322
91	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.14881366
92	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.13569017
93	SA1_27219007_Chip-Seq_Bcells_Human	1.13467722
94	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.13305738
95	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12942737
96	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.12812029
97	* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.12752824
98	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.12313544
99	TAF15_26573619_Chip-Seq_HEK293_Human	1.11598433
100	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.11115677
101	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.11023753
102	SOX2_20726797_ChIP-Seq_SW620_Human	1.10236663
103	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.10173446
104	TCF7_22412390_ChIP-Seq_EML_Mouse	1.09831876
105	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.09829894
106	AHR_22903824_ChIP-Seq_MCF-7_Human	1.09181927
107	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.08984164
108	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.08411277
109	STAT3_23295773_ChIP-Seq_U87_Human	1.08330132
110	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.07920734
111	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.07270733
112	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.05548829
113	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.05060128
114	TP53_16413492_ChIP-PET_HCT116_Human	1.04940295
115	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04748183
116	* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.04151537
117	ZNF274_21170338_ChIP-Seq_K562_Hela	1.03486268
118	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.02853385
119	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01917961
120	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.01892660
121	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.01749270
122	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.00692294
123	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.00200200
124	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.99850997
125	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.99706869
126	* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.99587328
127	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.97959224
128	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.97797315
129	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.97586935
130	* GATA6_25053715_ChIP-Seq_YYC3_Human	0.96709394
131	* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.96147373
132	* FOXO3_23340844_ChIP-Seq_DLD1_Human	0.95963028
133	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.95731579
134	TCF4_23295773_ChIP-Seq_U87_Human	0.95305578
135	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.94453404
136	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.93934458
137	BCOR_27268052_Chip-Seq_Bcells_Human	0.93662733
138	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.93228180
139	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.93209575
140	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.92946396
141	CTCF_27219007_Chip-Seq_Bcells_Human	0.92877646
142	RNF2_27304074_Chip-Seq_NSC_Mouse	0.92288391
143	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.92130139
144	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.91976504
145	TP53_18474530_ChIP-ChIP_U2OS_Human	0.91427327
146	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.91343726
147	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.90186977
148	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.89762301
149	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.87748814
150	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.83871158
151	RUNX2_22187159_ChIP-Seq_PCA_Human	0.83842594
152	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.83481404
153	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.83443474
154	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.83258558
155	BCAT_22108803_ChIP-Seq_LS180_Human	0.83226690
156	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.83074899
157	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.82986641
158	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.82986641
159	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.82941448

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	7.81407233
2	MP0003880_abnormal_central_pattern	4.82821635
3	MP0003635_abnormal_synaptic_transmissio	4.34849072
4	MP0004270_analgesia	3.89091739
5	MP0000566_synostosis	3.64821116
6	MP0002063_abnormal_learning/memory/cond	3.48397147
7	MP0009745_abnormal_behavioral_response	3.43398887
8	MP0004264_abnormal_extraembryonic_tissu	3.34654554
9	MP0009379_abnormal_foot_pigmentation	3.18654676
10	MP0002064_seizures	3.16201946
11	MP0009046_muscle_twitch	2.87615652
12	MP0002572_abnormal_emotion/affect_behav	2.81535266
13	MP0001968_abnormal_touch/_nociception	2.79852831
14	MP0001486_abnormal_startle_reflex	2.55840463
15	MP0005423_abnormal_somatic_nervous	2.55402583
16	MP0002734_abnormal_mechanical_nocicepti	2.50436773
17	MP0002272_abnormal_nervous_system	2.43206176
18	MP0002822_catalepsy	2.39100852
19	MP0002098_abnormal_vibrissa_morphology	2.37101359
20	MP0003705_abnormal_hypodermis_morpholog	2.36771733
21	MP0001501_abnormal_sleep_pattern	2.33744752
22	MP0009780_abnormal_chondrocyte_physiolo	2.24649663
23	MP0002736_abnormal_nociception_after	2.09527807
24	MP0001440_abnormal_grooming_behavior	2.03248181
25	MP0002735_abnormal_chemical_nociception	2.03153493
26	MP0008569_lethality_at_weaning	2.00379144
27	MP0003183_abnormal_peptide_metabolism	1.99633644
28	MP0003453_abnormal_keratinocyte_physiol	1.97585017
29	MP0003879_abnormal_hair_cell	1.94145015
30	MP0004858_abnormal_nervous_system	1.83049204
31	MP0010234_abnormal_vibrissa_follicle	1.77923573
32	MP0004043_abnormal_pH_regulation	1.75538015
33	MP0001970_abnormal_pain_threshold	1.74365298
34	MP0002067_abnormal_sensory_capabilities	1.73778058
35	MP0004811_abnormal_neuron_physiology	1.73412282
36	MP0001216_abnormal_epidermal_layer	1.70234171
37	MP0002733_abnormal_thermal_nociception	1.69431941
38	MP0000778_abnormal_nervous_system	1.69038455
39	MP0002557_abnormal_social/conspecific_i	1.68197886
40	MP0003787_abnormal_imprinting	1.68101841
41	MP0002184_abnormal_innervation	1.63963110
42	MP0000678_abnormal_parathyroid_gland	1.63766936
43	MP0003191_abnormal_cellular_cholesterol	1.63661974
44	MP0005646_abnormal_pituitary_gland	1.60817178
45	MP0003329_amyloid_beta_deposits	1.59353551
46	MP0004885_abnormal_endolymph	1.59125872
47	MP0000383_abnormal_hair_follicle	1.57542150
48	MP0000377_abnormal_hair_follicle	1.52282613
49	MP0002796_impaired_skin_barrier	1.51835811
50	MP0004782_abnormal_surfactant_physiolog	1.51054931
51	MP0002249_abnormal_larynx_morphology	1.50923371
52	MP0002909_abnormal_adrenal_gland	1.46171250
53	MP0000955_abnormal_spinal_cord	1.42367569
54	MP0005386_behavior/neurological_phenoty	1.40412856
55	MP0004924_abnormal_behavior	1.40412856
56	MP0003941_abnormal_skin_development	1.34106121
57	MP0002882_abnormal_neuron_morphology	1.31372252
58	MP0001984_abnormal_olfaction	1.31199355
59	MP0002066_abnormal_motor_capabilities/c	1.29599654
60	MP0003633_abnormal_nervous_system	1.27179424
61	MP0004381_abnormal_hair_follicle	1.25094872
62	MP0001666_abnormal_nutrient_absorption	1.23547801
63	MP0005645_abnormal_hypothalamus_physiol	1.23378583
64	MP0004019_abnormal_vitamin_homeostasis	1.22355202
65	MP0004947_skin_inflammation	1.20422604
66	MP0001188_hyperpigmentation	1.19927139
67	MP0000579_abnormal_nail_morphology	1.19382877
68	MP0001502_abnormal_circadian_rhythm	1.16691853
69	MP0001765_abnormal_ion_homeostasis	1.16234319
70	MP0003075_altered_response_to	1.14019973
71	MP0005360_urolithiasis	1.12902601
72	MP0002060_abnormal_skin_morphology	1.08529154
73	MP0003631_nervous_system_phenotype	1.05299654
74	MP0000762_abnormal_tongue_morphology	1.01548899
75	MP0008961_abnormal_basal_metabolism	1.01223150
76	MP0003878_abnormal_ear_physiology	1.00721654
77	MP0005377_hearing/vestibular/ear_phenot	1.00721654
78	MP0001177_atelectasis	1.00048027
79	MP0000569_abnormal_digit_pigmentation	0.99853912
80	MP0002152_abnormal_brain_morphology	0.99063486
81	MP0000751_myopathy	0.96008457
82	MP0006276_abnormal_autonomic_nervous	0.94499281
83	MP0010352_gastrointestinal_tract_polyps	0.93220466
84	MP0002069_abnormal_eating/drinking_beha	0.92995600
85	MP0008874_decreased_physiological_sensi	0.92432063
86	MP0002234_abnormal_pharynx_morphology	0.88517280
87	MP0004742_abnormal_vestibular_system	0.87776005
88	MP0009931_abnormal_skin_appearance	0.87437098
89	MP0008872_abnormal_physiological_respon	0.86683229
90	MP0005409_darkened_coat_color	0.86486695
91	MP0005248_abnormal_Harderian_gland	0.86086691
92	MP0003123_paternal_imprinting	0.85116738
93	MP0004142_abnormal_muscle_tone	0.84823265
94	MP0005394_taste/olfaction_phenotype	0.84384057
95	MP0005499_abnormal_olfactory_system	0.84384057
96	MP0001905_abnormal_dopamine_level	0.84002878
97	MP0002089_abnormal_postnatal_growth/wei	0.83548347
98	MP0001849_ear_inflammation	0.82552447
99	MP0003866_abnormal_defecation	0.81792965
100	MP0002876_abnormal_thyroid_physiology	0.81195246
101	MP0005365_abnormal_bile_salt	0.79235400
102	MP0003638_abnormal_response/metabolism_	0.78070385
103	MP0010386_abnormal_urinary_bladder	0.76818529
104	MP0000462_abnormal_digestive_system	0.76746911
105	MP0000367_abnormal_coat/_hair	0.76629719
106	MP0010771_integument_phenotype	0.74939344
107	MP0000647_abnormal_sebaceous_gland	0.74747127
108	MP0004484_altered_response_of	0.73544561
109	MP0001963_abnormal_hearing_physiology	0.72605979
110	MP0010155_abnormal_intestine_physiology	0.72558544
111	MP0000627_abnormal_mammary_gland	0.72429264
112	MP0000681_abnormal_thyroid_gland	0.71659314
113	MP0004147_increased_porphyrin_level	0.71619105
114	MP0001664_abnormal_digestion	0.71617575
115	MP0010678_abnormal_skin_adnexa	0.70413285
116	MP0005275_abnormal_skin_tensile	0.70359936
117	MP0004510_myositis	0.70013453
118	MP0004085_abnormal_heartbeat	0.68896377
119	MP0004145_abnormal_muscle_electrophysio	0.68295902
120	MP0000477_abnormal_intestine_morphology	0.67925918
121	MP0003632_abnormal_nervous_system	0.66848898
122	MP0005501_abnormal_skin_physiology	0.66303721
123	MP0003283_abnormal_digestive_organ	0.64034859
124	MP0002229_neurodegeneration	0.63908905
125	MP0001346_abnormal_lacrimal_gland	0.63684289
126	MP0003122_maternal_imprinting	0.62682770
127	MP0005085_abnormal_gallbladder_physiolo	0.61466574
128	MP0009053_abnormal_anal_canal	0.60352270
129	MP0003566_abnormal_cell_adhesion	0.60109331
130	MP0000537_abnormal_urethra_morphology	0.59921885
131	MP0001529_abnormal_vocalization	0.59642167
132	MP0000631_abnormal_neuroendocrine_gland	0.59263085
133	MP0005551_abnormal_eye_electrophysiolog	0.58141779
134	MP0005535_abnormal_body_temperature	0.57718211
135	MP0000427_abnormal_hair_cycle	0.57023631
136	MP0002090_abnormal_vision	0.56238285
137	MP0005166_decreased_susceptibility_to	0.56220123
138	MP0005167_abnormal_blood-brain_barrier	0.55161103
139	MP0001485_abnormal_pinna_reflex	0.54912076
140	MP0000604_amyloidosis	0.54615786
141	MP0003690_abnormal_glial_cell	0.54441930
142	MP0002752_abnormal_somatic_nervous	0.54343926
143	MP0000467_abnormal_esophagus_morphology	0.54165439
144	MP0003634_abnormal_glial_cell	0.53441725
145	MP0004215_abnormal_myocardial_fiber	0.52117007
146	MP0002254_reproductive_system_inflammat	0.51513477
147	MP0010769_abnormal_survival	0.51428987
148	MP0000920_abnormal_myelination	0.51182187
149	MP0000013_abnormal_adipose_tissue	0.50032773

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	8.22977550
2	Myokymia (HP:0002411)	7.39223744
3	Abnormality of nail color (HP:0100643)	5.99248574
4	Focal seizures (HP:0007359)	5.86560116
5	Right ventricular cardiomyopathy (HP:0011663)	5.25450727
6	Visual hallucinations (HP:0002367)	5.13512050
7	Epileptic encephalopathy (HP:0200134)	5.04616112
8	Febrile seizures (HP:0002373)	4.64333037
9	Pili torti (HP:0003777)	4.59515733
10	Progressive cerebellar ataxia (HP:0002073)	4.52042037
11	Atonic seizures (HP:0010819)	4.45205033
12	Congenital ichthyosiform erythroderma (HP:0007431)	4.01412528
13	Absence seizures (HP:0002121)	3.99181524
14	Increased IgE level (HP:0003212)	3.89966711
15	Alopecia of scalp (HP:0002293)	3.87335705
16	Abnormality of the salivary glands (HP:0010286)	3.85294801
17	Hyperactive renin-angiotensin system (HP:0000841)	3.81686785
18	Generalized tonic-clonic seizures (HP:0002069)	3.77786248
19	Action tremor (HP:0002345)	3.70923650
20	Dialeptic seizures (HP:0011146)	3.69749026
21	Abnormal hair laboratory examination (HP:0003328)	3.65567268
22	Broad-based gait (HP:0002136)	3.58072905
23	Woolly hair (HP:0002224)	3.49984768
24	Impaired vibration sensation in the lower limbs (HP:0002166)	3.48363171
25	Lip pit (HP:0100267)	3.37000551
26	Gaze-evoked nystagmus (HP:0000640)	3.34639590
27	Ankle clonus (HP:0011448)	3.33117566
28	Poor eye contact (HP:0000817)	3.13385465
29	Supranuclear gaze palsy (HP:0000605)	3.13359997
30	Onycholysis (HP:0001806)	3.13188020
31	Ventricular fibrillation (HP:0001663)	3.11854118
32	Depression (HP:0000716)	3.09812708
33	Amblyopia (HP:0000646)	3.07857681
34	Dysmetria (HP:0001310)	3.04776162
35	Erythroderma (HP:0001019)	3.04660603
36	Hyperventilation (HP:0002883)	3.04523911
37	Genetic anticipation (HP:0003743)	3.04379036
38	Dysdiadochokinesis (HP:0002075)	3.03010094
39	Thick nail (HP:0001805)	3.02899544
40	Urinary bladder sphincter dysfunction (HP:0002839)	2.98761454
41	Flat acetabular roof (HP:0003180)	2.98219764
42	Abnormality of the lower motor neuron (HP:0002366)	2.93408336
43	Postural instability (HP:0002172)	2.90754971
44	Malnutrition (HP:0004395)	2.89052982
45	Mutism (HP:0002300)	2.86875936
46	Corneal erosion (HP:0200020)	2.85875649
47	Impaired social interactions (HP:0000735)	2.84309527
48	Abnormal social behavior (HP:0012433)	2.84309527
49	Papilledema (HP:0001085)	2.78834971
50	Obstructive sleep apnea (HP:0002870)	2.76334475
51	Abnormal eating behavior (HP:0100738)	2.76286007
52	Bronchomalacia (HP:0002780)	2.73304969
53	Erythema (HP:0010783)	2.73091267
54	Decreased circulating renin level (HP:0003351)	2.71224739
55	Impaired smooth pursuit (HP:0007772)	2.66861581
56	Akinesia (HP:0002304)	2.66263849
57	Stereotypic behavior (HP:0000733)	2.65709744
58	Abnormality of secondary sexual hair (HP:0009888)	2.65206490
59	Abnormality of the axillary hair (HP:0100134)	2.65206490
60	Torticollis (HP:0000473)	2.65139437
61	Abnormal blistering of the skin (HP:0008066)	2.64894458
62	Truncal ataxia (HP:0002078)	2.63835396
63	Anxiety (HP:0000739)	2.62532313
64	Megalencephaly (HP:0001355)	2.60461508
65	Abnormality of renin-angiotensin system (HP:0000847)	2.59672718
66	Intention tremor (HP:0002080)	2.57287669
67	Focal dystonia (HP:0004373)	2.53792766
68	Excessive salivation (HP:0003781)	2.49829725
69	Drooling (HP:0002307)	2.49829725
70	Impaired vibratory sensation (HP:0002495)	2.39464318
71	Nail dystrophy (HP:0008404)	2.38745473
72	Fetal akinesia sequence (HP:0001989)	2.38344305
73	Hyperparathyroidism (HP:0000843)	2.38183146
74	Dysmetric saccades (HP:0000641)	2.36952285
75	Urinary urgency (HP:0000012)	2.36731816
76	Annular pancreas (HP:0001734)	2.33898821
77	Neonatal short-limb short stature (HP:0008921)	2.32399696
78	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.31845860
79	Abnormality of the dental root (HP:0006486)	2.31552183
80	Taurodontia (HP:0000679)	2.31552183
81	Abnormality of permanent molar morphology (HP:0011071)	2.31552183
82	Ankyloglossia (HP:0010296)	2.28187387
83	Hemiplegia (HP:0002301)	2.27136197
84	Diplopia (HP:0000651)	2.26966584
85	Abnormality of binocular vision (HP:0011514)	2.26966584
86	Bundle branch block (HP:0011710)	2.26882378
87	Abnormality of ocular smooth pursuit (HP:0000617)	2.26498224
88	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.21407760
89	Metabolic alkalosis (HP:0200114)	2.20237463
90	Hemiparesis (HP:0001269)	2.16679017
91	Absent speech (HP:0001344)	2.16237915
92	Palmoplantar keratoderma (HP:0000982)	2.15812414
93	Aplasia involving bones of the extremities (HP:0009825)	2.14557685
94	Aplasia involving bones of the upper limbs (HP:0009823)	2.14557685
95	Aplasia of the phalanges of the hand (HP:0009802)	2.14557685
96	Bradykinesia (HP:0002067)	2.13736309
97	Epileptiform EEG discharges (HP:0011182)	2.12802227
98	Hyperaldosteronism (HP:0000859)	2.12386329
99	Scanning speech (HP:0002168)	2.12055365
100	Pointed chin (HP:0000307)	2.11757874
101	Hypoplasia of dental enamel (HP:0006297)	2.11747643
102	Abnormality of molar (HP:0011077)	2.07703574
103	Abnormality of molar morphology (HP:0011070)	2.07703574
104	Spastic gait (HP:0002064)	2.06792388
105	Partial duplication of thumb phalanx (HP:0009944)	2.05994456
106	Craniofacial dystonia (HP:0012179)	2.04893268
107	Split foot (HP:0001839)	2.03413694
108	Hypohidrosis (HP:0000966)	2.02889988
109	Abnormality of chloride homeostasis (HP:0011422)	2.02336281
110	Progressive inability to walk (HP:0002505)	2.01996082
111	Neuronal loss in central nervous system (HP:0002529)	2.01823705
112	Lower limb amyotrophy (HP:0007210)	2.00973265
113	Abnormality of the dental pulp (HP:0006479)	2.00273085
114	Plantar hyperkeratosis (HP:0007556)	1.99836032
115	Hyperkalemia (HP:0002153)	1.99203259
116	Neonatal death (HP:0003811)	1.99178451
117	Generalized myoclonic seizures (HP:0002123)	1.98681253
118	Status epilepticus (HP:0002133)	1.96133895
119	EEG with generalized epileptiform discharges (HP:0011198)	1.95041729
120	Cerebral inclusion bodies (HP:0100314)	1.94129012
121	Acanthosis nigricans (HP:0000956)	1.93374166
122	Incomplete penetrance (HP:0003829)	1.92492061
123	Dehydration (HP:0001944)	1.91370527
124	Neurofibrillary tangles (HP:0002185)	1.90674514
125	Germ cell neoplasia (HP:0100728)	1.90407042
126	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.90225682
127	Sparse eyelashes (HP:0000653)	1.88764825
128	Hypotrichosis (HP:0001006)	1.87426908
129	Palmoplantar hyperkeratosis (HP:0000972)	1.87198355
130	Curly hair (HP:0002212)	1.85784425
131	Abnormality of hair growth rate (HP:0011363)	1.85468799
132	Slow-growing hair (HP:0002217)	1.85468799
133	Lower limb muscle weakness (HP:0007340)	1.85176649
134	Hypsarrhythmia (HP:0002521)	1.84190125
135	Milia (HP:0001056)	1.84090417
136	Parakeratosis (HP:0001036)	1.84023243
137	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.82582477
138	Sleep apnea (HP:0010535)	1.82578558
139	Spinal cord compression (HP:0002176)	1.81709171
140	Inability to walk (HP:0002540)	1.80418946
141	Gait ataxia (HP:0002066)	1.79927086
142	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.78782167
143	Ridged nail (HP:0001807)	1.78326288
144	Absent eyelashes (HP:0000561)	1.78227742
145	Abnormal EKG (HP:0003115)	1.77731401
146	Abnormality of salivation (HP:0100755)	1.77511158
147	Advanced eruption of teeth (HP:0006288)	1.77273570
148	Fragile nails (HP:0001808)	1.77082934
149	Distal upper limb amyotrophy (HP:0007149)	1.76252410
150	Upper limb amyotrophy (HP:0009129)	1.76252410
151	Conjunctival hamartoma (HP:0100780)	1.74725715
152	Amelogenesis imperfecta (HP:0000705)	1.74486577
153	Abnormality of sodium homeostasis (HP:0010931)	1.74260070
154	Insomnia (HP:0100785)	1.73443935
155	Abnormality of saccadic eye movements (HP:0000570)	1.72017256
156	Visceral angiomatosis (HP:0100761)	1.71630076
157	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.71450028
158	Polyphagia (HP:0002591)	1.71051951
159	Syncope (HP:0001279)	1.69568594
160	Inappropriate behavior (HP:0000719)	1.69320244
161	Intellectual disability, profound (HP:0002187)	1.69153595
162	Palmar hyperkeratosis (HP:0010765)	1.69099916
163	Axonal loss (HP:0003447)	1.68637616
164	Thickened helices (HP:0000391)	1.67989638
165	Thin bony cortex (HP:0002753)	1.66757834
166	Insidious onset (HP:0003587)	1.66629607
167	Termporal pattern (HP:0011008)	1.66629607
168	Lower limb asymmetry (HP:0100559)	1.66392021
169	Rapidly progressive (HP:0003678)	1.66079174

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA4	4.82218672
2	NTRK3	4.70560898
3	MAP3K9	3.90151662
4	CDK12	3.72418966
5	MST1R	3.22892182
6	EPHA2	3.10140645
7	DAPK2	2.84861534
8	MAP3K4	2.68101448
9	MARK1	2.55519535
10	MINK1	2.53122304
11	PRKD3	2.50244444
12	PAK6	2.32541021
13	TRIB3	2.27458115
14	KSR2	2.25177371
15	MAP2K7	2.23425147
16	NTRK2	1.98713157
17	MAP3K12	1.95808264
18	MATK	1.93210769
19	CAMKK1	1.91244206
20	RIPK4	1.89340748
21	MAP2K4	1.85553567
22	PRPF4B	1.84584010
23	CASK	1.78943249
24	DAPK1	1.78935549
25	PIK3CA	1.75076751
26	KSR1	1.71274804
27	SIK1	1.58950157
28	MAPKAPK3	1.54808081
29	CDK5	1.54723460
30	MET	1.53596691
31	STK38	1.52246982
32	CDK19	1.51674562
33	MAP3K2	1.50827503
34	SIK2	1.48445669
35	TAOK1	1.48261980
36	ERBB2	1.47309925
37	ERN1	1.47285974
38	NTRK1	1.43491295
39	PLK2	1.41174246
40	TNIK	1.40701922
41	EEF2K	1.32579398
42	MAP3K13	1.31342980
43	PRKG2	1.30998893
44	MAPK13	1.29257150
45	SMG1	1.24760873
46	PRKCG	1.21784386
47	CAMK1	1.21235001
48	GRK5	1.19055550
49	TYRO3	1.18501807
50	ICK	1.17898625
51	FES	1.10274479
52	LATS2	1.10174330
53	PTK2	1.02129895
54	STK11	0.99483626
55	ARAF	0.96391593
56	CAMK2A	0.92525227
57	SGK2	0.92045537
58	SGK494	0.91547504
59	SGK223	0.91547504
60	FER	0.90334756
61	RAF1	0.87366812
62	PRKCH	0.84620040
63	TESK1	0.84470868
64	MAP3K7	0.84372248
65	SGK3	0.83774562
66	CDK18	0.83525800
67	PTK2B	0.82444335
68	NME1	0.81701897
69	CDK15	0.81688711
70	MARK2	0.81032826
71	MUSK	0.78952553
72	UHMK1	0.78555653
73	ALK	0.77556785
74	FGFR4	0.76612758
75	PDK1	0.75483443
76	FGFR3	0.75450220
77	SGK1	0.74701788
78	CDK14	0.73895279
79	PTK6	0.73609136
80	CAMK2B	0.73500946
81	DMPK	0.73344270
82	BMPR2	0.71741126
83	SIK3	0.71715506
84	CDK11A	0.71092736
85	PHKG2	0.71014707
86	PHKG1	0.71014707
87	MAP3K1	0.70754979
88	RET	0.70437167
89	DYRK1A	0.69435960
90	PAK3	0.68728387
91	CAMKK2	0.68579535
92	PINK1	0.68353802
93	PDPK1	0.64567590
94	STK24	0.63493364
95	CAMK1D	0.62574505
96	CAMK4	0.61636864
97	PNCK	0.60373520
98	GRK6	0.59375413
99	LMTK2	0.59254926
100	OXSR1	0.57576673
101	EPHB2	0.57478161
102	TNK2	0.56951375
103	FGFR1	0.54976197
104	MAP2K1	0.54023914
105	MAP3K6	0.52421980
106	MAP2K2	0.50807853
107	RPS6KB2	0.50742418
108	CCNB1	0.49150789
109	NEK6	0.48453836
110	PDGFRA	0.48445333
111	WNK1	0.47515018
112	RPS6KA3	0.47155355
113	MAPK15	0.47011999
114	CDC42BPA	0.46957480
115	RIPK1	0.46828024
116	CDK7	0.45983191
117	RPS6KA2	0.45895842
118	ACVR1B	0.44556577
119	PRKCZ	0.43589461
120	BMX	0.43526188
121	FYN	0.42851403
122	BRSK1	0.42187604
123	PKN2	0.42172896
124	DAPK3	0.42108845
125	RPS6KB1	0.41244727
126	MAP3K11	0.40954178
127	CSNK1G2	0.40026779
128	PRKCE	0.39871285
129	MAPK12	0.39185523
130	DDR2	0.39154495
131	AKT3	0.38550083
132	MAPK10	0.38338418
133	FGR	0.37998917
134	CAMK1G	0.33965947
135	CAMK2G	0.32302096
136	MAP2K6	0.30526386
137	FGFR2	0.28397543
138	PRKD2	0.28184843

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.41216811
2	Synaptic vesicle cycle_Homo sapiens_hsa04721	3.06329493
3	Long-term potentiation_Homo sapiens_hsa04720	2.79535352
4	Olfactory transduction_Homo sapiens_hsa04740	2.76510946
5	Circadian entrainment_Homo sapiens_hsa04713	2.73592698
6	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.72076915
7	Glutamatergic synapse_Homo sapiens_hsa04724	2.57736276
8	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.52884102
9	Amphetamine addiction_Homo sapiens_hsa05031	2.44113638
10	GABAergic synapse_Homo sapiens_hsa04727	2.37090256
11	Morphine addiction_Homo sapiens_hsa05032	2.28335292
12	Salivary secretion_Homo sapiens_hsa04970	2.27568433
13	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.08023124
14	Gastric acid secretion_Homo sapiens_hsa04971	2.05795659
15	Insulin secretion_Homo sapiens_hsa04911	2.01071464
16	Dopaminergic synapse_Homo sapiens_hsa04728	2.00845960
17	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.97309626
18	Cholinergic synapse_Homo sapiens_hsa04725	1.88960567
19	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.73963587
20	Long-term depression_Homo sapiens_hsa04730	1.70336219
21	Histidine metabolism_Homo sapiens_hsa00340	1.68602701
22	Calcium signaling pathway_Homo sapiens_hsa04020	1.67755125
23	GnRH signaling pathway_Homo sapiens_hsa04912	1.65164371
24	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.64241821
25	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.62710870
26	Renin secretion_Homo sapiens_hsa04924	1.61511873
27	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.54586598
28	Taste transduction_Homo sapiens_hsa04742	1.53942797
29	Serotonergic synapse_Homo sapiens_hsa04726	1.50351694
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.47865362
31	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.41290223
32	Arginine biosynthesis_Homo sapiens_hsa00220	1.41226167
33	Glioma_Homo sapiens_hsa05214	1.37651190
34	Cocaine addiction_Homo sapiens_hsa05030	1.36605580
35	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.30269284
36	cAMP signaling pathway_Homo sapiens_hsa04024	1.30121917
37	Fat digestion and absorption_Homo sapiens_hsa04975	1.24073741
38	Type II diabetes mellitus_Homo sapiens_hsa04930	1.24056588
39	Gap junction_Homo sapiens_hsa04540	1.23720737
40	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.21614722
41	Melanogenesis_Homo sapiens_hsa04916	1.21107836
42	ErbB signaling pathway_Homo sapiens_hsa04012	1.21064367
43	Axon guidance_Homo sapiens_hsa04360	1.20133169
44	Estrogen signaling pathway_Homo sapiens_hsa04915	1.19359998
45	Collecting duct acid secretion_Homo sapiens_hsa04966	1.16119899
46	Linoleic acid metabolism_Homo sapiens_hsa00591	1.11055257
47	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.08237283
48	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.07453112
49	Nitrogen metabolism_Homo sapiens_hsa00910	1.05458599
50	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.02007164
51	Pancreatic secretion_Homo sapiens_hsa04972	1.01918311
52	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.00356587
53	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.97538476
54	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.96272389
55	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.92221922
56	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.90793152
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.88320665
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.88058108
59	VEGF signaling pathway_Homo sapiens_hsa04370	0.87625468
60	Choline metabolism in cancer_Homo sapiens_hsa05231	0.85687056
61	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.85458807
62	Notch signaling pathway_Homo sapiens_hsa04330	0.83718501
63	Oocyte meiosis_Homo sapiens_hsa04114	0.83487055
64	Protein digestion and absorption_Homo sapiens_hsa04974	0.82466448
65	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.81613078
66	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.81038763
67	Ether lipid metabolism_Homo sapiens_hsa00565	0.78743420
68	Sphingolipid metabolism_Homo sapiens_hsa00600	0.77669551
69	Phenylalanine metabolism_Homo sapiens_hsa00360	0.75450192
70	MAPK signaling pathway_Homo sapiens_hsa04010	0.75439822
71	Arginine and proline metabolism_Homo sapiens_hsa00330	0.74906117
72	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.74828517
73	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.74744084
74	PPAR signaling pathway_Homo sapiens_hsa03320	0.72435813
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71544929
76	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.70990433
77	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.70961444
78	Ras signaling pathway_Homo sapiens_hsa04014	0.70317551
79	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.69975681
80	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.68336938
81	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.67208291
82	Vibrio cholerae infection_Homo sapiens_hsa05110	0.66544639
83	Rap1 signaling pathway_Homo sapiens_hsa04015	0.66063855
84	Phototransduction_Homo sapiens_hsa04744	0.65879892
85	Renin-angiotensin system_Homo sapiens_hsa04614	0.65863472
86	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.64960002
87	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.62516124
88	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.60724432
89	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.59791588
90	Circadian rhythm_Homo sapiens_hsa04710	0.59442896
91	mTOR signaling pathway_Homo sapiens_hsa04150	0.59330654
92	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.58721051
93	Non-small cell lung cancer_Homo sapiens_hsa05223	0.58571694
94	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.58498209
95	Cardiac muscle contraction_Homo sapiens_hsa04260	0.57525603
96	Endometrial cancer_Homo sapiens_hsa05213	0.57386951
97	Glucagon signaling pathway_Homo sapiens_hsa04922	0.57173553
98	Wnt signaling pathway_Homo sapiens_hsa04310	0.57146420
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.57094562
100	Endocytosis_Homo sapiens_hsa04144	0.55214654
101	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.55144470
102	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.53863744
103	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.50842589
104	Adherens junction_Homo sapiens_hsa04520	0.50536553
105	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.47252476
106	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.47194283
107	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.47192460
108	ABC transporters_Homo sapiens_hsa02010	0.46047347
109	Thyroid cancer_Homo sapiens_hsa05216	0.45688325
110	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.45639543
111	AMPK signaling pathway_Homo sapiens_hsa04152	0.45075327
112	African trypanosomiasis_Homo sapiens_hsa05143	0.43903367
113	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.43870241
114	Renal cell carcinoma_Homo sapiens_hsa05211	0.43599249
115	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.43514488
116	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.42321458
117	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42159074
118	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.42146645
119	Bile secretion_Homo sapiens_hsa04976	0.40795795
120	Chemokine signaling pathway_Homo sapiens_hsa04062	0.39734760
121	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.39476622
122	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.39416457
123	Insulin signaling pathway_Homo sapiens_hsa04910	0.38100906
124	Alcoholism_Homo sapiens_hsa05034	0.36404731
125	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.35853040
126	Type I diabetes mellitus_Homo sapiens_hsa04940	0.32098449
127	Tight junction_Homo sapiens_hsa04530	0.32096900
128	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.31917651
129	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.31644050
130	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.30791503
131	Mineral absorption_Homo sapiens_hsa04978	0.30631098
132	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.30524018

RAPGEFL1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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