RAPH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the Mig10/Rap1-interacting adaptor molecule/Lamellipodin family of adapter proteins, which function in cell migration. Members of this family contain pleckstrin-homology domains, Ras-association domains, and proline-rich C-termini. The protein encoded by this gene regulates actin dynamics through interaction with Ena/Vasodilator proteins as well as direct binding to filamentous actin to regulate actin network assembly. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dicarboxylic acid biosynthetic process (GO:0043650)4.43244303
2bundle of His cell to Purkinje myocyte communication (GO:0086069)3.79409008
3skin morphogenesis (GO:0043589)3.62368754
4regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.61284015
5cell adhesion mediated by integrin (GO:0033627)3.56961470
6urea cycle (GO:0000050)3.55927533
7urea metabolic process (GO:0019627)3.55927533
8regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.48495918
9regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.41768045
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.41561960
11regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.28706666
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.28408619
13complement activation, alternative pathway (GO:0006957)3.27265752
14phospholipid homeostasis (GO:0055091)3.24681768
15cardiac myofibril assembly (GO:0055003)3.24109436
16kynurenine metabolic process (GO:0070189)3.19998435
17lymphangiogenesis (GO:0001946)3.19553098
18regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.16929926
19tryptophan catabolic process (GO:0006569)3.16291125
20indole-containing compound catabolic process (GO:0042436)3.16291125
21indolalkylamine catabolic process (GO:0046218)3.16291125
22regulation of protein activation cascade (GO:2000257)3.15147892
23regulation of fibrinolysis (GO:0051917)3.13020273
24nitrogen cycle metabolic process (GO:0071941)3.11316663
25carnitine shuttle (GO:0006853)3.02114783
26tryptophan metabolic process (GO:0006568)3.00688057
27desmosome organization (GO:0002934)2.98467621
28fatty acid transmembrane transport (GO:1902001)2.98001373
29nucleobase catabolic process (GO:0046113)2.94962532
30collagen fibril organization (GO:0030199)2.94714105
31retina vasculature morphogenesis in camera-type eye (GO:0061299)2.94674087
32regulation of complement activation (GO:0030449)2.93629539
33regulation of plasminogen activation (GO:0010755)2.92223488
34positive regulation of cardiac muscle cell differentiation (GO:2000727)2.91899954
35cell communication involved in cardiac conduction (GO:0086065)2.90768749
36aromatic amino acid family catabolic process (GO:0009074)2.85965891
37cardiac muscle hypertrophy (GO:0003300)2.85069979
38regulation of axon extension involved in axon guidance (GO:0048841)2.84712760
39chondrocyte proliferation (GO:0035988)2.84489676
40negative regulation of fibrinolysis (GO:0051918)2.84454794
41myofibril assembly (GO:0030239)2.83768985
42plasma membrane repair (GO:0001778)2.77700270
43regulation of sarcomere organization (GO:0060297)2.76002404
44positive regulation of cardiac muscle hypertrophy (GO:0010613)2.72497175
45positive regulation of muscle hypertrophy (GO:0014742)2.72497175
46cell migration involved in sprouting angiogenesis (GO:0002042)2.72214384
47ventricular cardiac muscle cell action potential (GO:0086005)2.71712545
48regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.71702120
49protein carboxylation (GO:0018214)2.71497695
50peptidyl-glutamic acid carboxylation (GO:0017187)2.71497695
51embryonic retina morphogenesis in camera-type eye (GO:0060059)2.70898533
52high-density lipoprotein particle remodeling (GO:0034375)2.69101323
53regulation of cell communication by electrical coupling (GO:0010649)2.68468543
54COPII vesicle coating (GO:0048208)2.68283530
55metanephric mesenchyme development (GO:0072075)2.66680232
56triglyceride homeostasis (GO:0070328)2.65136694
57acylglycerol homeostasis (GO:0055090)2.65136694
58striated muscle hypertrophy (GO:0014897)2.64478588
59regulation of triglyceride catabolic process (GO:0010896)2.63506704
60phospholipid efflux (GO:0033700)2.62993857
61negative regulation of protein activation cascade (GO:2000258)2.62447829
62erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.60399238
63L-phenylalanine catabolic process (GO:0006559)2.60399238
64negative regulation of keratinocyte proliferation (GO:0010839)2.59346496
65negative regulation of lipase activity (GO:0060192)2.59087088
66epoxygenase P450 pathway (GO:0019373)2.57009243
67pyrimidine nucleobase catabolic process (GO:0006208)2.56888400
68regulation of sequestering of triglyceride (GO:0010889)2.56113371
69cholesterol efflux (GO:0033344)2.54928639
70reverse cholesterol transport (GO:0043691)2.54109060
71kidney mesenchyme development (GO:0072074)2.53954459
72epithelial cell differentiation involved in kidney development (GO:0035850)2.53700919
73hemidesmosome assembly (GO:0031581)2.53099030
74regulation of axon guidance (GO:1902667)2.52898040
75cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.52113648
76cardiac conduction (GO:0061337)2.51546480
77omega-hydroxylase P450 pathway (GO:0097267)2.51092110
78substrate-dependent cell migration (GO:0006929)2.50606517
79adult heart development (GO:0007512)2.49074446
80forebrain neuron development (GO:0021884)2.47757296
81regulation of cardiac muscle cell differentiation (GO:2000725)2.47047419
82exogenous drug catabolic process (GO:0042738)2.46366100
83bile acid and bile salt transport (GO:0015721)2.44923971
84lymph vessel development (GO:0001945)2.44836646
85regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.44013945
86cellular biogenic amine catabolic process (GO:0042402)2.43558551
87amine catabolic process (GO:0009310)2.43558551
88regulation of relaxation of muscle (GO:1901077)2.43087506
89negative regulation of fatty acid transport (GO:2000192)2.42785314
90vocalization behavior (GO:0071625)2.41491373
91regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.40796481
92smooth muscle tissue development (GO:0048745)2.40623103
93negative regulation of axon extension involved in axon guidance (GO:0048843)2.40445994
94endodermal cell differentiation (GO:0035987)2.39886027
95regulation of bile acid biosynthetic process (GO:0070857)2.39632364
96muscle hypertrophy (GO:0014896)2.39111646
97response to pheromone (GO:0019236)2.38247437
98glutamate metabolic process (GO:0006536)2.37710485
99positive regulation of fatty acid oxidation (GO:0046321)2.36962603
100vascular endothelial growth factor signaling pathway (GO:0038084)2.35204944
101cerebellar Purkinje cell differentiation (GO:0021702)2.35058786
102regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.34864493
103bile acid biosynthetic process (GO:0006699)2.34751440
104erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.34687966
105L-phenylalanine metabolic process (GO:0006558)2.34687966
106positive regulation of protein autophosphorylation (GO:0031954)2.34644582
107homocysteine metabolic process (GO:0050667)2.34433817
108regulation of transforming growth factor beta2 production (GO:0032909)2.34206548
109regulation of cardiac muscle contraction (GO:0055117)2.33314115
110amino-acid betaine metabolic process (GO:0006577)2.32950784
111macroautophagy (GO:0016236)2.32594705
112indolalkylamine metabolic process (GO:0006586)2.32271909
113drug catabolic process (GO:0042737)2.32042051
114regulation of type B pancreatic cell apoptotic process (GO:2000674)2.31400348
115positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.30854225
116glomerulus development (GO:0032835)2.29824195
117tyrosine metabolic process (GO:0006570)2.29262710
118adrenergic receptor signaling pathway (GO:0071875)2.29043259
119dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.28877410
120sarcomere organization (GO:0045214)2.28079941
121gonadal mesoderm development (GO:0007506)2.28033653
122regulation of integrin-mediated signaling pathway (GO:2001044)2.27584973
123neuron remodeling (GO:0016322)2.27215579
124positive regulation of heart rate (GO:0010460)2.26854351
125protein heterotrimerization (GO:0070208)2.26650813
126hippo signaling (GO:0035329)2.26440526
127sequestering of extracellular ligand from receptor (GO:0035581)2.26260191
128myoblast fusion (GO:0007520)2.25671535
129neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.25404024
130fibrinolysis (GO:0042730)2.25389409
131protein-lipid complex remodeling (GO:0034368)2.25373150
132macromolecular complex remodeling (GO:0034367)2.25373150
133plasma lipoprotein particle remodeling (GO:0034369)2.25373150
134cardiac chamber formation (GO:0003207)2.25277531
135ionotropic glutamate receptor signaling pathway (GO:0035235)2.25152250
136plasma lipoprotein particle assembly (GO:0034377)2.24907031
137cellular glucuronidation (GO:0052695)2.24882348
138cell communication by electrical coupling (GO:0010644)2.24722206
139neuron recognition (GO:0008038)2.24527327
140paraxial mesoderm development (GO:0048339)2.23158006
141regulation of synapse assembly (GO:0051963)2.22670086
142positive regulation of glycogen metabolic process (GO:0070875)2.22433635
143neuron projection extension involved in neuron projection guidance (GO:1902284)2.20662330
144axon extension involved in axon guidance (GO:0048846)2.20662330
145wound healing, spreading of epidermal cells (GO:0035313)2.20015256
146negative regulation of wound healing (GO:0061045)2.19805898
147venous blood vessel morphogenesis (GO:0048845)2.17463968
148artery development (GO:0060840)2.15393780
149ganglion development (GO:0061548)2.14547391
150negative regulation of chondrocyte differentiation (GO:0032331)2.10687335
151sprouting angiogenesis (GO:0002040)2.09249484
152apical protein localization (GO:0045176)2.08359688
153negative chemotaxis (GO:0050919)2.08182858
154endothelial cell morphogenesis (GO:0001886)2.07367514
155fibroblast migration (GO:0010761)2.07103327
156regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.05998143
157substrate adhesion-dependent cell spreading (GO:0034446)2.04456024
158insulin-like growth factor receptor signaling pathway (GO:0048009)2.03659911
159cytoskeletal anchoring at plasma membrane (GO:0007016)2.03134943
160embryonic foregut morphogenesis (GO:0048617)2.02017732
161glomerular visceral epithelial cell development (GO:0072015)1.99528081
162negative regulation of axon guidance (GO:1902668)1.99326293
163syncytium formation by plasma membrane fusion (GO:0000768)1.99009661
164cellular response to vitamin D (GO:0071305)1.98445314
165positive regulation of cell junction assembly (GO:1901890)1.98234952
166positive regulation of focal adhesion assembly (GO:0051894)1.98234952
167positive regulation of adherens junction organization (GO:1903393)1.96735334
168gap junction assembly (GO:0016264)1.96270180
169chondrocyte development (GO:0002063)1.95645097
170cellular response to hepatocyte growth factor stimulus (GO:0035729)1.95538770
171response to hepatocyte growth factor (GO:0035728)1.95538770
172cellular response to vitamin (GO:0071295)1.94447271
173* axon extension (GO:0048675)1.94407450
174negative regulation of hemostasis (GO:1900047)1.94349011
175negative regulation of blood coagulation (GO:0030195)1.94349011
176negative regulation of coagulation (GO:0050819)1.92895811
177epithelial cell-cell adhesion (GO:0090136)1.92759511
178basement membrane organization (GO:0071711)1.92602216
179coronary vasculature morphogenesis (GO:0060977)1.89485870
180collagen metabolic process (GO:0032963)1.89131688
181cell-substrate junction assembly (GO:0007044)1.87938561
182semaphorin-plexin signaling pathway (GO:0071526)1.87292266
183positive regulation of glycolytic process (GO:0045821)1.86581854
184multicellular organismal macromolecule metabolic process (GO:0044259)1.85072561
185endothelial cell chemotaxis (GO:0035767)1.84013766

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.54837470
2EZH2_22144423_ChIP-Seq_EOC_Human3.03250319
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31841223
4TAF15_26573619_Chip-Seq_HEK293_Human2.30298323
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.13289428
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.12160246
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09216404
8SMAD_19615063_ChIP-ChIP_OVARY_Human1.90531779
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88695734
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86348653
11PIAS1_25552417_ChIP-Seq_VCAP_Human1.85493703
12ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84516853
13* RXR_22158963_ChIP-Seq_LIVER_Mouse1.82635889
14* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.81202155
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80679508
16PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79986086
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76404114
18LXR_22158963_ChIP-Seq_LIVER_Mouse1.75078925
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.74053800
20* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.73882271
21SMAD4_21799915_ChIP-Seq_A2780_Human1.71055947
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69051763
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69025717
24* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.68568469
25* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67573988
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67513766
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67513766
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66657260
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.65817741
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.65805463
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63806138
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.63369049
33* BRD4_25478319_ChIP-Seq_HGPS_Human1.63042908
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62192859
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61354705
36P300_19829295_ChIP-Seq_ESCs_Human1.57027803
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56450649
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.56052821
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55557912
40* EP300_21415370_ChIP-Seq_HL-1_Mouse1.55177337
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54744277
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.53248870
43AHR_22903824_ChIP-Seq_MCF-7_Human1.47051280
44AR_21572438_ChIP-Seq_LNCaP_Human1.44834694
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.44144056
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43165322
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40803274
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40302180
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38477684
50DROSHA_22980978_ChIP-Seq_HELA_Human1.38389426
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37636484
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.36897594
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.35685474
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.33307583
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.33147267
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31574041
57PPARA_22158963_ChIP-Seq_LIVER_Mouse1.31493436
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31486480
59TP53_18474530_ChIP-ChIP_U2OS_Human1.31451340
60SALL4_18804426_ChIP-ChIP_XEN_Mouse1.30769246
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30257393
62* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29963759
63* FLI1_27457419_Chip-Seq_LIVER_Mouse1.26149449
64* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.25506489
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25397118
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24381845
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24381845
68VDR_22108803_ChIP-Seq_LS180_Human1.24121670
69* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23751922
70* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23692454
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23485400
72BCAT_22108803_ChIP-Seq_LS180_Human1.23378571
73ESR1_21235772_ChIP-Seq_MCF-7_Human1.22873900
74* TCF4_18268006_ChIP-ChIP_LS174T_Human1.22853426
75TP53_16413492_ChIP-PET_HCT116_Human1.22655672
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22607492
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21646399
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.21047313
79* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20971373
80* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20839083
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20764298
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.20663313
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.20078185
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19694587
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.19666320
86SMAD3_21741376_ChIP-Seq_HESCs_Human1.19500256
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19212753
88* E2F1_18555785_Chip-Seq_ESCs_Mouse1.18848174
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18332356
90* STAT3_23295773_ChIP-Seq_U87_Human1.17946507
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17483465
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16884634
93FOXA2_19822575_ChIP-Seq_HepG2_Human1.16717582
94* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16007355
95* NANOG_18555785_Chip-Seq_ESCs_Mouse1.14610191
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14138511
97NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14108597
98* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13792410
99* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13792410
100WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13647048
101* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12897066
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12816489
103* TCF4_23295773_ChIP-Seq_U87_Human1.12567087
104CLOCK_20551151_ChIP-Seq_293T_Human1.12530445
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12509500
106* NFE2_27457419_Chip-Seq_LIVER_Mouse1.12428480
107FUS_26573619_Chip-Seq_HEK293_Human1.12392964
108IGF1R_20145208_ChIP-Seq_DFB_Human1.12247079
109AR_25329375_ChIP-Seq_VCAP_Human1.11876675
110* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11606207
111* EZH2_27294783_Chip-Seq_NPCs_Mouse1.11598223
112* P53_22387025_ChIP-Seq_ESCs_Mouse1.10877476
113FOXO3_23340844_ChIP-Seq_DLD1_Human1.10639895
114* TP63_23658742_ChIP-Seq_EP156T_Human1.10332368
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09626996
116CBX2_27304074_Chip-Seq_ESCs_Mouse1.09613304
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09147393
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09043777
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08757933
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08458885
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07950943
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07928384
123NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07915839
124OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05040298
125HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04917211
126* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04508285
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03531893
128SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03430099
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02602688
130CJUN_26792858_Chip-Seq_BT549_Human1.02408518
131RUNX2_22187159_ChIP-Seq_PCA_Human1.01961098
132ESR1_20079471_ChIP-ChIP_T-47D_Human1.01384228
133* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01255842
134* CDX2_20551321_ChIP-Seq_CACO-2_Human1.01104641
135ISL1_27105846_Chip-Seq_CPCs_Mouse1.00417735
136CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99237296
137RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99204496
138SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99194364
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98559425
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.97863396
141Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97321452
142ER_23166858_ChIP-Seq_MCF-7_Human0.96684380
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96655243
144CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96402097
145TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96126677

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.20594053
2MP0002139_abnormal_hepatobiliary_system4.16238555
3MP0005085_abnormal_gallbladder_physiolo3.66800150
4MP0002837_dystrophic_cardiac_calcinosis3.21263583
5MP0000569_abnormal_digit_pigmentation3.08924528
6MP0005365_abnormal_bile_salt2.82745036
7MP0003252_abnormal_bile_duct2.64304034
8MP0003950_abnormal_plasma_membrane2.59696090
9MP0000751_myopathy2.48954586
10MP0010368_abnormal_lymphatic_system2.38897366
11MP0004215_abnormal_myocardial_fiber2.35937739
12MP0008875_abnormal_xenobiotic_pharmacok2.32830628
13MP0003566_abnormal_cell_adhesion2.31246945
14MP0005257_abnormal_intraocular_pressure2.25679442
15MP0010352_gastrointestinal_tract_polyps2.21999146
16MP0000516_abnormal_urinary_system2.12118436
17MP0005367_renal/urinary_system_phenotyp2.12118436
18MP0005670_abnormal_white_adipose2.07394304
19MP0000749_muscle_degeneration2.02999250
20MP0001958_emphysema2.02257045
21MP0003880_abnormal_central_pattern1.99027657
22MP0009379_abnormal_foot_pigmentation1.97558155
23MP0003279_aneurysm1.93349246
24MP0002735_abnormal_chemical_nociception1.92477968
25MP0006054_spinal_hemorrhage1.85568971
26MP0010329_abnormal_lipoprotein_level1.81045626
27MP0009697_abnormal_copulation1.77616212
28MP0004084_abnormal_cardiac_muscle1.77515972
29MP0006276_abnormal_autonomic_nervous1.75252474
30MP0003646_muscle_fatigue1.71983220
31MP0010234_abnormal_vibrissa_follicle1.70622330
32MP0005409_darkened_coat_color1.70050083
33MP0004085_abnormal_heartbeat1.68286055
34MP0002896_abnormal_bone_mineralization1.64865130
35MP0004484_altered_response_of1.61948563
36MP0001299_abnormal_eye_distance/1.60700383
37MP0000013_abnormal_adipose_tissue1.59857582
38MP0001188_hyperpigmentation1.59196840
39MP0003137_abnormal_impulse_conducting1.56096551
40MP0004130_abnormal_muscle_cell1.55984484
41MP0004510_myositis1.55722952
42MP0004859_abnormal_synaptic_plasticity1.53585331
43MP0005083_abnormal_biliary_tract1.53010018
44MP0005330_cardiomyopathy1.52196258
45MP0005503_abnormal_tendon_morphology1.51870608
46MP0003283_abnormal_digestive_organ1.51153198
47MP0002972_abnormal_cardiac_muscle1.48962936
48MP0000538_abnormal_urinary_bladder1.47633102
49MP0005023_abnormal_wound_healing1.47431832
50MP0001879_abnormal_lymphatic_vessel1.43011149
51MP0002877_abnormal_melanocyte_morpholog1.41307837
52MP0006138_congestive_heart_failure1.40189756
53MP0005248_abnormal_Harderian_gland1.38765938
54MP0008438_abnormal_cutaneous_collagen1.38103211
55MP0003868_abnormal_feces_composition1.38027189
56MP0002060_abnormal_skin_morphology1.37425988
57MP0004272_abnormal_basement_membrane1.36549535
58MP0003941_abnormal_skin_development1.35702869
59MP0000534_abnormal_ureter_morphology1.35097269
60MP0005275_abnormal_skin_tensile1.33689107
61MP0002295_abnormal_pulmonary_circulatio1.31751912
62MP0002168_other_aberrant_phenotype1.26967014
63MP0001968_abnormal_touch/_nociception1.26448500
64MP0008775_abnormal_heart_ventricle1.26006022
65MP0001542_abnormal_bone_strength1.22643425
66MP0010678_abnormal_skin_adnexa1.22044233
67MP0002254_reproductive_system_inflammat1.19598681
68MP0000767_abnormal_smooth_muscle1.19340491
69MP0005385_cardiovascular_system_phenoty1.19103257
70MP0001544_abnormal_cardiovascular_syste1.19103257
71MP0005620_abnormal_muscle_contractility1.18373654
72MP0009053_abnormal_anal_canal1.15357776
73MP0003828_pulmonary_edema1.15335549
74MP0002736_abnormal_nociception_after1.14684600
75MP0000003_abnormal_adipose_tissue1.14615269
76MP0004145_abnormal_muscle_electrophysio1.13822752
77MP0002127_abnormal_cardiovascular_syste1.11654968
78MP0010630_abnormal_cardiac_muscle1.11324479
79MP0004087_abnormal_muscle_fiber1.10473062
80MP0000462_abnormal_digestive_system1.09964895
81MP0005595_abnormal_vascular_smooth1.06639200
82MP0000733_abnormal_muscle_development1.06431594
83MP0005171_absent_coat_pigmentation1.03659819
84MP0000566_synostosis1.01991348
85MP0001440_abnormal_grooming_behavior1.00568088
86MP0005508_abnormal_skeleton_morphology1.00544217
87MP0000383_abnormal_hair_follicle0.99756235
88MP0000579_abnormal_nail_morphology0.99275788
89MP0004036_abnormal_muscle_relaxation0.98693021
90MP0002067_abnormal_sensory_capabilities0.95445399
91MP0000778_abnormal_nervous_system0.95349282
92MP0003385_abnormal_body_wall0.94809118
93MP0005084_abnormal_gallbladder_morpholo0.94649492
94MP0003942_abnormal_urinary_system0.91491866
95MP0002876_abnormal_thyroid_physiology0.91284349
96MP0003705_abnormal_hypodermis_morpholog0.91108776
97MP0000762_abnormal_tongue_morphology0.90698251
98MP0001501_abnormal_sleep_pattern0.90404714
99MP0002909_abnormal_adrenal_gland0.90045100
100MP0002108_abnormal_muscle_morphology0.89734316
101MP0001666_abnormal_nutrient_absorption0.89392800
102MP0009250_abnormal_appendicular_skeleto0.88268877
103MP0001915_intracranial_hemorrhage0.86755484
104MP0009384_cardiac_valve_regurgitation0.86715001
105MP0003755_abnormal_palate_morphology0.86096034
106MP0002118_abnormal_lipid_homeostasis0.85919398
107MP0002332_abnormal_exercise_endurance0.85786539
108MP0005076_abnormal_cell_differentiation0.84804548
109MP0002572_abnormal_emotion/affect_behav0.84396650
110MP0002063_abnormal_learning/memory/cond0.84192596
111MP0005448_abnormal_energy_balance0.83815788
112MP0003045_fibrosis0.82646972
113MP0004233_abnormal_muscle_weight0.82135581
114MP0003635_abnormal_synaptic_transmissio0.81155971
115MP0009780_abnormal_chondrocyte_physiolo0.79969423
116MP0004134_abnormal_chest_morphology0.79228208
117MP0003935_abnormal_craniofacial_develop0.78610983
118MP0002971_abnormal_brown_adipose0.78450810
119MP0000537_abnormal_urethra_morphology0.77737941
120MP0000432_abnormal_head_morphology0.77373886
121MP0005197_abnormal_uvea_morphology0.77145109
122MP0001486_abnormal_startle_reflex0.76545573
123MP0004782_abnormal_surfactant_physiolog0.76009961
124MP0003122_maternal_imprinting0.75928648
125MP0002128_abnormal_blood_circulation0.75093140
126MP0002234_abnormal_pharynx_morphology0.74637296
127MP0002106_abnormal_muscle_physiology0.73635550
128MP0000467_abnormal_esophagus_morphology0.73499663
129MP0009046_muscle_twitch0.73289621
130MP0004381_abnormal_hair_follicle0.73235164
131MP0005369_muscle_phenotype0.72773765
132MP0002282_abnormal_trachea_morphology0.72709275
133MP0000759_abnormal_skeletal_muscle0.72534576
134MP0009745_abnormal_behavioral_response0.72076948
135MP0005623_abnormal_meninges_morphology0.71903776
136MP0000163_abnormal_cartilage_morphology0.71837790
137MP0000428_abnormal_craniofacial_morphol0.71550821
138MP0005395_other_phenotype0.70906125
139MP0005334_abnormal_fat_pad0.70065592
140MP0004270_analgesia0.69934915
141MP0002184_abnormal_innervation0.69628625
142MP0005386_behavior/neurological_phenoty0.69386134
143MP0004924_abnormal_behavior0.69386134
144MP0003195_calcinosis0.69338634
145MP0002269_muscular_atrophy0.68635756
146MP0001614_abnormal_blood_vessel0.68457978
147MP0002925_abnormal_cardiovascular_devel0.68434093
148MP0004019_abnormal_vitamin_homeostasis0.68130485
149MP0003091_abnormal_cell_migration0.68080195
150MP0003115_abnormal_respiratory_system0.67672490
151MP0004858_abnormal_nervous_system0.67362147
152MP0005187_abnormal_penis_morphology0.67252151
153MP0000427_abnormal_hair_cycle0.66991142
154MP0001243_abnormal_dermal_layer0.65514651
155MP0002557_abnormal_social/conspecific_i0.65457744
156MP0001177_atelectasis0.64579869
157MP0009840_abnormal_foam_cell0.63676260
158MP0003191_abnormal_cellular_cholesterol0.62983687
159MP0003937_abnormal_limbs/digits/tail_de0.62732243
160MP0002233_abnormal_nose_morphology0.62628258

Predicted human phenotypes

RankGene SetZ-score
1Calf muscle hypertrophy (HP:0008981)4.64414122
2Premature rupture of membranes (HP:0001788)4.54118120
3Sudden death (HP:0001699)4.52943250
4Protrusio acetabuli (HP:0003179)4.34498495
5Muscle hypertrophy of the lower extremities (HP:0008968)4.13999304
6Right ventricular cardiomyopathy (HP:0011663)4.04344225
7Vascular tortuosity (HP:0004948)3.80655026
8Arterial tortuosity (HP:0005116)3.72016476
9Febrile seizures (HP:0002373)3.67253518
10Deep venous thrombosis (HP:0002625)3.65701437
11Abnormality of the calf musculature (HP:0001430)3.63902808
12Prolonged partial thromboplastin time (HP:0003645)3.59284619
13Aortic dissection (HP:0002647)3.58587920
14Syncope (HP:0001279)3.58093011
15Atrial fibrillation (HP:0005110)3.51912221
16Hypoalphalipoproteinemia (HP:0003233)3.40982795
17Ventricular tachycardia (HP:0004756)3.33072789
18Primary atrial arrhythmia (HP:0001692)3.32193692
19Complement deficiency (HP:0004431)3.31293475
20Epidermoid cyst (HP:0200040)3.16524661
21Atrophic scars (HP:0001075)3.14654537
22Aortic aneurysm (HP:0004942)3.08358054
23Supraventricular tachycardia (HP:0004755)3.03084273
24Fair hair (HP:0002286)3.01574775
25Hyperventilation (HP:0002883)3.00263469
26Neonatal short-limb short stature (HP:0008921)2.99780499
27Supraventricular arrhythmia (HP:0005115)2.99061011
28Intrahepatic cholestasis (HP:0001406)2.97943311
29Hypolipoproteinemia (HP:0010981)2.91486106
30Cardiovascular calcification (HP:0011915)2.83685742
31Overgrowth (HP:0001548)2.81447632
32Soft skin (HP:0000977)2.80773647
33Joint hemorrhage (HP:0005261)2.79337572
34Hypobetalipoproteinemia (HP:0003563)2.66482573
35Xanthomatosis (HP:0000991)2.66082116
36Distal lower limb muscle weakness (HP:0009053)2.65987653
37Shallow orbits (HP:0000586)2.64497991
38Hypoventilation (HP:0002791)2.60328515
39Abnormality of dentin (HP:0010299)2.58918689
40Conjugated hyperbilirubinemia (HP:0002908)2.58238602
41Abnormality of monocarboxylic acid metabolism (HP:0010996)2.54504172
42Skin nodule (HP:0200036)2.53031802
43Hypoplastic ischia (HP:0003175)2.52536432
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.52488980
45Prolonged QT interval (HP:0001657)2.52363615
46Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.50910871
47Popliteal pterygium (HP:0009756)2.50265597
48Abnormality of the ischium (HP:0003174)2.49788147
49Distal lower limb amyotrophy (HP:0008944)2.45463709
50Cervical subluxation (HP:0003308)2.44178051
51Mitral valve prolapse (HP:0001634)2.42249032
52EMG: myopathic abnormalities (HP:0003458)2.37968165
53Abnormality of complement system (HP:0005339)2.37936018
54Focal motor seizures (HP:0011153)2.36450768
55Lipoatrophy (HP:0100578)2.36148697
56Wormian bones (HP:0002645)2.34429292
57Vascular calcification (HP:0004934)2.33454283
58Hyporeflexia of lower limbs (HP:0002600)2.33319700
59Abnormality of the left ventricular outflow tract (HP:0011103)2.25499318
60Subaortic stenosis (HP:0001682)2.25499318
61Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.24963628
62Glomerulonephritis (HP:0000099)2.24954190
63Absent speech (HP:0001344)2.24812574
64Short nail (HP:0001799)2.24399350
65Dilated cardiomyopathy (HP:0001644)2.23895252
66Wrist flexion contracture (HP:0001239)2.22213589
67Abnormality of the common coagulation pathway (HP:0010990)2.21991300
68Cerebral aneurysm (HP:0004944)2.21088522
69Lower limb amyotrophy (HP:0007210)2.20481820
70Broad metatarsal (HP:0001783)2.19989814
71Fragile skin (HP:0001030)2.19132313
72Generalized hypopigmentation of hair (HP:0011358)2.14932769
73Ankle contracture (HP:0006466)2.13203147
74Hyperlipoproteinemia (HP:0010980)2.12484803
75Abnormality of the nasal septum (HP:0000419)2.11734464
76Bradycardia (HP:0001662)2.10242693
77Increased connective tissue (HP:0009025)2.09857427
78Myocardial infarction (HP:0001658)2.09323502
79Abnormality of pyrimidine metabolism (HP:0004353)2.07791116
80Genu recurvatum (HP:0002816)2.07789643
81Bundle branch block (HP:0011710)2.07471557
82Osteolytic defects of the hand bones (HP:0009699)2.07144556
83Osteolytic defects of the phalanges of the hand (HP:0009771)2.07144556
84Hyperextensible skin (HP:0000974)2.07042783
85Bladder diverticulum (HP:0000015)2.06967383
86Ventricular arrhythmia (HP:0004308)2.06381703
87Striae distensae (HP:0001065)2.05843117
88Exotropia (HP:0000577)2.05505306
89Abnormal atrioventricular conduction (HP:0005150)2.04464332
90Heart block (HP:0012722)2.03561410
91Excessive salivation (HP:0003781)2.02572055
92Drooling (HP:0002307)2.02572055
93Aortic regurgitation (HP:0001659)2.01759139
94Hypercholesterolemia (HP:0003124)2.00514930
95Tibial bowing (HP:0002982)2.00514883
96Spinal rigidity (HP:0003306)1.97881600
97Blue irides (HP:0000635)1.97054504
98Abnormality of incisor morphology (HP:0011063)1.95941183
99Vertebral arch anomaly (HP:0008438)1.94896757
100Type 1 muscle fiber predominance (HP:0003803)1.93256169
101Abnormal EKG (HP:0003115)1.91872098
102Submucous cleft hard palate (HP:0000176)1.91708561
103Obstructive sleep apnea (HP:0002870)1.91188954
104Aneurysm (HP:0002617)1.90082291
105Nephritis (HP:0000123)1.89252432
106Hypoplasia of the iris (HP:0007676)1.88462209
107Vitreoretinal degeneration (HP:0000655)1.88027497
108Atrioventricular block (HP:0001678)1.87727928
109Limited hip movement (HP:0008800)1.87377195
110Natal tooth (HP:0000695)1.86323842
111Spondylolisthesis (HP:0003302)1.85900124
112Spontaneous abortion (HP:0005268)1.83684784
113Abnormality of aromatic amino acid family metabolism (HP:0004338)1.83011115
114Abnormality of the intrinsic pathway (HP:0010989)1.82352056
115Difficulty climbing stairs (HP:0003551)1.82302611
116Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80385227
117Abnormal delivery (HP:0001787)1.78676252
118Osteoarthritis (HP:0002758)1.78069541
119Abnormality of methionine metabolism (HP:0010901)1.78021083
120Absent frontal sinuses (HP:0002688)1.77739869
121Focal seizures (HP:0007359)1.77504931
122Progressive cerebellar ataxia (HP:0002073)1.77343172
123Broad-based gait (HP:0002136)1.75952350
124Mild short stature (HP:0003502)1.75742602
125Impaired social interactions (HP:0000735)1.75062048
126Abnormal social behavior (HP:0012433)1.75062048
127Hyperammonemia (HP:0001987)1.74799501
128Muscle fiber splitting (HP:0003555)1.73818352
129Coronal craniosynostosis (HP:0004440)1.73779530
130Pulmonary artery stenosis (HP:0004415)1.73550901
131Muscular dystrophy (HP:0003560)1.73349706
132Follicular hyperkeratosis (HP:0007502)1.73096931
133Alopecia of scalp (HP:0002293)1.73075279
134Hypochromic microcytic anemia (HP:0004840)1.73002374
135Hypophosphatemic rickets (HP:0004912)1.72472161
136Epileptic encephalopathy (HP:0200134)1.71698428
137Joint laxity (HP:0001388)1.71578259
138Mitral stenosis (HP:0001718)1.71356642
139Sleep apnea (HP:0010535)1.70762045
140Abnormality of the right ventricle (HP:0001707)1.70466514
141Papillary thyroid carcinoma (HP:0002895)1.69579229
142Wide anterior fontanel (HP:0000260)1.69430806
143Genetic anticipation (HP:0003743)1.69322052
144Mildly elevated creatine phosphokinase (HP:0008180)1.69173924
145Pulmonic stenosis (HP:0001642)1.68607289
146Lymphangioma (HP:0100764)1.68225155
147Hyperglycemia (HP:0003074)1.67574087
148Round ear (HP:0100830)1.67044831
149Aortic valve stenosis (HP:0001650)1.66981870
150Ketosis (HP:0001946)1.66297510
151Abnormality of the Achilles tendon (HP:0005109)1.66214585
152Hip contracture (HP:0003273)1.66090280
153Advanced eruption of teeth (HP:0006288)1.62722012
154Pterygium (HP:0001059)1.62624890
155Bowel diverticulosis (HP:0005222)1.59677954
156Buphthalmos (HP:0000557)1.59405554
157Asymmetry of the thorax (HP:0001555)1.58844067
158Morphological abnormality of the middle ear (HP:0008609)1.58767327
159Cubitus valgus (HP:0002967)1.57694010
160Blue sclerae (HP:0000592)1.56505053
161Ovoid vertebral bodies (HP:0003300)1.53475925
162Infantile muscular hypotonia (HP:0008947)1.53338572
163Spinal cord compression (HP:0002176)1.53190523
164Knee flexion contracture (HP:0006380)1.51278178
165Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.51026728
166Congenital glaucoma (HP:0001087)1.50971411
167Abnormality of the acetabulum (HP:0003170)1.49352018
168Peritonitis (HP:0002586)1.48669320
169Mitral regurgitation (HP:0001653)1.48577097
170Ulnar bowing (HP:0003031)1.47762682
171Arthropathy (HP:0003040)1.45281947
172Dilatation of the ascending aorta (HP:0005111)1.44519573
173Hydroxyprolinuria (HP:0003080)1.42024735
174Abnormality of proline metabolism (HP:0010907)1.42024735
175Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.40849019
176Vertebral compression fractures (HP:0002953)1.39685413
177Delayed gross motor development (HP:0002194)1.39282514

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.67005544
2INSRR2.40659219
3NTRK12.36137201
4MET2.28600816
5CAMK1D2.16098213
6LATS12.13698320
7OBSCN2.12605180
8CAMK1G2.11583617
9SIK21.93556206
10PIK3CA1.88046537
11AKT31.85478209
12MUSK1.76684584
13ZAK1.74126614
14MAP3K41.68990419
15SGK21.64914469
16TNIK1.64571948
17SIK11.61821970
18NTRK31.61422312
19EPHB21.60175511
20DAPK21.59098631
21PNCK1.57626112
22MAP2K71.57288844
23MAP2K41.53949730
24TTN1.53468109
25MOS1.52129976
26PLK21.50965925
27LATS21.44349991
28EPHA21.43495870
29EPHA41.40972895
30CAMK41.38464698
31BCR1.38318565
32TIE11.38050331
33PHKG11.36733821
34PHKG21.36733821
35GRK71.32283185
36DMPK1.27976342
37ERBB41.27412591
38YES11.26106039
39ICK1.25272671
40LIMK11.24742147
41SIK31.24421871
42FRK1.23230743
43SGK31.22892003
44MARK11.20033177
45FER1.19728665
46STK38L1.15364694
47STK381.15336424
48MYLK1.14062409
49PAK21.11823471
50PDGFRA1.08175225
51LMTK21.06326981
52CAMK2A1.05119905
53MAP3K71.04653145
54GRK51.03326843
55PKN11.03185186
56STK31.01983931
57STK241.00745724
58MAPK131.00379390
59PRKAA20.99643452
60MAPK120.99473813
61CAMK10.98567076
62WNK10.96287667
63PRKCE0.96255346
64MKNK20.95771663
65SGK10.94222998
66ERBB20.94199575
67ROCK20.92976594
68MAP3K120.92104997
69STK390.90402769
70CAMK2D0.89985719
71ERBB30.88867237
72DDR20.85832320
73PTK2B0.85378687
74MTOR0.85005213
75MST1R0.83278774
76RIPK10.82045395
77EIF2AK20.79453741
78TRPM70.75798453
79PAK30.74207521
80NUAK10.73938982
81RIPK40.73388561
82MELK0.73094630
83GSK3A0.71468987
84PAK60.70502579
85SGK4940.69735967
86SGK2230.69735967
87MAP3K60.68239352
88MAP3K140.65454831
89PDGFRB0.64968188
90TGFBR20.64898023
91TAOK30.64881075
92PRKAA10.63794052
93TESK10.63672287
94PKN20.62889879
95BMPR1B0.61808472
96BRD40.61479927
97PAK40.61300279
98PRKG10.61256448
99EPHA30.60939123
100MAP3K90.60617189
101MAP3K20.59257065
102PRKD30.59078110
103ROCK10.56243045
104CAMK2B0.56153486
105KSR10.55796504
106RPS6KA20.55669234
107MAP3K30.55611385
108STK160.55578460
109ABL20.55322596
110PTK20.54939598
111FGFR30.54125626
112CAMKK20.54063515
113MAP3K50.51626590
114MAPK70.51420767
115PRPF4B0.51382343
116FGFR20.51281949
117STK110.49323835
118CDC42BPA0.49259546
119PINK10.48709551
120FGFR10.46407974
121PBK0.46156391
122NEK90.45643534
123PRKCZ0.44997218
124RET0.43952841
125AKT20.43139206
126JAK10.42796401
127CSNK1A1L0.42595877
128EPHB10.42469218
129PRKG20.42413403
130PRKCG0.41658745
131MINK10.40802785
132PRKACG0.40790748
133EIF2AK30.40555511
134CDK120.40287853
135PRKACA0.39560451
136PRKD20.39525131
137CDK50.38753682
138TRIM280.38525590
139CAMK2G0.36749986
140CSNK1G20.36363587
141MAP2K10.36341860

Predicted pathways (KEGG)

RankGene SetZ-score
1Arginine biosynthesis_Homo sapiens_hsa002203.34676666
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.73110761
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.65293233
4Complement and coagulation cascades_Homo sapiens_hsa046102.37634176
5Tryptophan metabolism_Homo sapiens_hsa003802.12459730
6Fatty acid degradation_Homo sapiens_hsa000711.96144833
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.94157568
8Nicotine addiction_Homo sapiens_hsa050331.88078984
9Lysine degradation_Homo sapiens_hsa003101.77652652
10Dilated cardiomyopathy_Homo sapiens_hsa054141.73236839
11Circadian rhythm_Homo sapiens_hsa047101.67855953
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.67163545
13PPAR signaling pathway_Homo sapiens_hsa033201.66107689
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.63782016
15Caffeine metabolism_Homo sapiens_hsa002321.60839773
16Starch and sucrose metabolism_Homo sapiens_hsa005001.55110305
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53894156
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52794857
19Nitrogen metabolism_Homo sapiens_hsa009101.52575984
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49208969
21Staphylococcus aureus infection_Homo sapiens_hsa051501.47652383
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.44761177
23Fatty acid metabolism_Homo sapiens_hsa012121.40001227
24Bile secretion_Homo sapiens_hsa049761.36834106
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.32968119
26Butanoate metabolism_Homo sapiens_hsa006501.31561006
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29081884
28Protein digestion and absorption_Homo sapiens_hsa049741.27728195
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25358133
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23313199
31Propanoate metabolism_Homo sapiens_hsa006401.20840510
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18876923
33beta-Alanine metabolism_Homo sapiens_hsa004101.15693441
34Proteoglycans in cancer_Homo sapiens_hsa052051.14944117
35Tight junction_Homo sapiens_hsa045301.12739879
36Vitamin B6 metabolism_Homo sapiens_hsa007501.12217361
37Phenylalanine metabolism_Homo sapiens_hsa003601.09805784
38Hippo signaling pathway_Homo sapiens_hsa043901.08968530
39Histidine metabolism_Homo sapiens_hsa003401.08278231
40TGF-beta signaling pathway_Homo sapiens_hsa043501.07971694
41Retinol metabolism_Homo sapiens_hsa008301.07647583
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07460331
43Fat digestion and absorption_Homo sapiens_hsa049751.06452047
44Peroxisome_Homo sapiens_hsa041461.06366952
45Prion diseases_Homo sapiens_hsa050201.05577961
46Vitamin digestion and absorption_Homo sapiens_hsa049771.04347355
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02100480
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01290893
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01171855
50Glutamatergic synapse_Homo sapiens_hsa047240.98517916
51Tyrosine metabolism_Homo sapiens_hsa003500.97992503
52Thyroid hormone synthesis_Homo sapiens_hsa049180.96678212
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95039808
54Circadian entrainment_Homo sapiens_hsa047130.94014852
55ECM-receptor interaction_Homo sapiens_hsa045120.93789497
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.92447493
57Axon guidance_Homo sapiens_hsa043600.91909088
58ABC transporters_Homo sapiens_hsa020100.91169072
59Chemical carcinogenesis_Homo sapiens_hsa052040.90547127
60Taste transduction_Homo sapiens_hsa047420.89381369
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86548654
62Adherens junction_Homo sapiens_hsa045200.86474543
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86177739
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84923099
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84655966
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81458032
67Type II diabetes mellitus_Homo sapiens_hsa049300.81354046
68Calcium signaling pathway_Homo sapiens_hsa040200.79826036
69Cardiac muscle contraction_Homo sapiens_hsa042600.79793072
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77636948
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77129750
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76788127
73PI3K-Akt signaling pathway_Homo sapiens_hsa041510.75471818
74Sphingolipid metabolism_Homo sapiens_hsa006000.74444183
75AMPK signaling pathway_Homo sapiens_hsa041520.73888367
76Mineral absorption_Homo sapiens_hsa049780.73172898
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72755887
78Long-term potentiation_Homo sapiens_hsa047200.72709236
79GABAergic synapse_Homo sapiens_hsa047270.71313357
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70576901
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70373883
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.69984079
83Amphetamine addiction_Homo sapiens_hsa050310.69976717
84Gap junction_Homo sapiens_hsa045400.69504059
85Hedgehog signaling pathway_Homo sapiens_hsa043400.68929626
86Renin secretion_Homo sapiens_hsa049240.68778785
87Fatty acid elongation_Homo sapiens_hsa000620.68046941
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67159322
89Glucagon signaling pathway_Homo sapiens_hsa049220.67070207
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64729168
91Morphine addiction_Homo sapiens_hsa050320.64723505
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64673070
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64299055
94mTOR signaling pathway_Homo sapiens_hsa041500.62159073
95Vibrio cholerae infection_Homo sapiens_hsa051100.61564704
96Estrogen signaling pathway_Homo sapiens_hsa049150.61252848
97Fatty acid biosynthesis_Homo sapiens_hsa000610.60634860
98Melanoma_Homo sapiens_hsa052180.60443240
99Insulin secretion_Homo sapiens_hsa049110.60426725
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59692624
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59643476
102Ovarian steroidogenesis_Homo sapiens_hsa049130.59284485
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.59234785
104Dorso-ventral axis formation_Homo sapiens_hsa043200.58867344
105Small cell lung cancer_Homo sapiens_hsa052220.58022740
106Cocaine addiction_Homo sapiens_hsa050300.57405033
107Sulfur metabolism_Homo sapiens_hsa009200.57061997
108Prostate cancer_Homo sapiens_hsa052150.56140194
109Rap1 signaling pathway_Homo sapiens_hsa040150.54510904
110Endometrial cancer_Homo sapiens_hsa052130.54504427
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54476335
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54045265
113Pyruvate metabolism_Homo sapiens_hsa006200.53551737
114Renal cell carcinoma_Homo sapiens_hsa052110.52959700
115Wnt signaling pathway_Homo sapiens_hsa043100.52791955
116cAMP signaling pathway_Homo sapiens_hsa040240.51973287
117Salivary secretion_Homo sapiens_hsa049700.51827291
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51326514
119Focal adhesion_Homo sapiens_hsa045100.51181975
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50651741
121Insulin resistance_Homo sapiens_hsa049310.48762138
122Long-term depression_Homo sapiens_hsa047300.48521005
123Cholinergic synapse_Homo sapiens_hsa047250.47483411
124Oxytocin signaling pathway_Homo sapiens_hsa049210.47375700
125Insulin signaling pathway_Homo sapiens_hsa049100.46422819
126MicroRNAs in cancer_Homo sapiens_hsa052060.44213840
127Synaptic vesicle cycle_Homo sapiens_hsa047210.43942671
128Melanogenesis_Homo sapiens_hsa049160.43938546
129Dopaminergic synapse_Homo sapiens_hsa047280.43358101
130GnRH signaling pathway_Homo sapiens_hsa049120.43199383
131Serotonergic synapse_Homo sapiens_hsa047260.42970304
132ErbB signaling pathway_Homo sapiens_hsa040120.42492836
133Glycerolipid metabolism_Homo sapiens_hsa005610.41357398
134African trypanosomiasis_Homo sapiens_hsa051430.41058088
135Amoebiasis_Homo sapiens_hsa051460.40248422
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37685651
137Olfactory transduction_Homo sapiens_hsa047400.37579768
138Cyanoamino acid metabolism_Homo sapiens_hsa004600.37256401
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35562536
140Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35018364
141Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34315352
142Viral myocarditis_Homo sapiens_hsa054160.32889767

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