RAPSN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins that are receptor associated proteins of the synapse. The encoded protein contains a conserved cAMP-dependent protein kinase phosphorylation site, and plays a critical role in clustering and anchoring nicotinic acetylcholine receptors at synaptic sites by linking the receptors to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. Mutations in this gene may play a role in postsynaptic congenital myasthenic syndromes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)8.61605376
2actin-myosin filament sliding (GO:0033275)8.61605376
3sarcomere organization (GO:0045214)7.02827222
4actin-mediated cell contraction (GO:0070252)6.90657496
5regulation of skeletal muscle contraction (GO:0014819)6.39918946
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.26037269
7skeletal muscle contraction (GO:0003009)6.21815711
8plasma membrane repair (GO:0001778)6.06769441
9myofibril assembly (GO:0030239)5.66712612
10sarcoplasmic reticulum calcium ion transport (GO:0070296)5.54882328
11positive regulation of myoblast differentiation (GO:0045663)5.34508810
12cardiac myofibril assembly (GO:0055003)5.32136045
13muscle structure development (GO:0061061)5.22542133
14actin filament-based movement (GO:0030048)5.10458420
15negative regulation of potassium ion transmembrane transport (GO:1901380)5.10273128
16negative regulation of protein localization to cell surface (GO:2000009)4.88111102
17skeletal muscle fiber development (GO:0048741)4.84646626
18striated muscle contraction (GO:0006941)4.82403410
19cardiac muscle cell development (GO:0055013)4.70815683
20positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.68935373
21negative regulation of nitric-oxide synthase activity (GO:0051001)4.63408660
22multicellular organismal movement (GO:0050879)4.55962185
23musculoskeletal movement (GO:0050881)4.55962185
24striated muscle tissue development (GO:0014706)4.54731734
25skeletal muscle tissue regeneration (GO:0043403)4.49251157
26cardiac cell development (GO:0055006)4.42217811
27positive regulation of myotube differentiation (GO:0010831)4.34600316
28actomyosin structure organization (GO:0031032)4.32484533
29cardiac muscle contraction (GO:0060048)4.25405983
30neuromuscular synaptic transmission (GO:0007274)4.24851218
31myotube differentiation (GO:0014902)4.22828575
32heart process (GO:0003015)4.20728897
33heart contraction (GO:0060047)4.20728897
34muscle cell fate commitment (GO:0042693)4.17225054
35response to gravity (GO:0009629)4.07674971
36muscle tissue development (GO:0060537)4.03721031
37DNA deamination (GO:0045006)4.02743307
38myotube cell development (GO:0014904)4.02738572
39regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.01897566
40regulation of relaxation of muscle (GO:1901077)4.01730633
41tricarboxylic acid cycle (GO:0006099)4.01037753
42muscle adaptation (GO:0043500)3.99119708
43regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.95506061
44sequestering of actin monomers (GO:0042989)3.93613501
45membrane raft organization (GO:0031579)3.91881759
46striated muscle cell development (GO:0055002)3.87487245
47regulation of myoblast differentiation (GO:0045661)3.85605873
48response to activity (GO:0014823)3.85546316
49regulation of sarcomere organization (GO:0060297)3.81915494
50muscle fiber development (GO:0048747)3.75006994
51response to muscle activity (GO:0014850)3.74109722
52response to inactivity (GO:0014854)3.72826797
53muscle contraction (GO:0006936)3.71804329
54positive regulation of skeletal muscle tissue development (GO:0048643)3.68870259
55regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.68183574
56response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.68057858
57skeletal muscle adaptation (GO:0043501)3.66782731
58regulation of membrane repolarization (GO:0060306)3.66219047
59regulation of cell communication by electrical coupling (GO:0010649)3.56724912
60regulation of myotube differentiation (GO:0010830)3.56449230
61regulation of actin filament-based movement (GO:1903115)3.49736763
62cardiac muscle tissue morphogenesis (GO:0055008)3.47174558
63regulation of skeletal muscle cell differentiation (GO:2001014)3.46477608
64oxidative phosphorylation (GO:0006119)3.45711754
65glycogen biosynthetic process (GO:0005978)3.45187871
66glucan biosynthetic process (GO:0009250)3.45187871
67striated muscle atrophy (GO:0014891)3.44600286
68muscle tissue morphogenesis (GO:0060415)3.44481390
69regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.44243467
70regulation of muscle system process (GO:0090257)3.39560704
71muscle cell development (GO:0055001)3.39426494
72positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.37135053
73positive regulation of striated muscle cell differentiation (GO:0051155)3.33433921
74muscle system process (GO:0003012)3.32997193
75negative regulation of skeletal muscle tissue development (GO:0048642)3.27394089
76cytidine metabolic process (GO:0046087)3.25605998
77cytidine catabolic process (GO:0006216)3.25605998
78cytidine deamination (GO:0009972)3.25605998
79muscle cell cellular homeostasis (GO:0046716)3.25503074
80skeletal muscle cell differentiation (GO:0035914)3.25149438
81carnitine shuttle (GO:0006853)3.24891805
82negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.23972101
83regulation of muscle contraction (GO:0006937)3.23307741
84IMP metabolic process (GO:0046040)3.20691703
85regulation of striated muscle contraction (GO:0006942)3.20635096
86regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.19953196
87negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.17924447
88cellular response to zinc ion (GO:0071294)3.16431169
89negative regulation of potassium ion transport (GO:0043267)3.14317512
90neuromuscular junction development (GO:0007528)3.14116554
91regulation of skeletal muscle fiber development (GO:0048742)3.09875476
92positive regulation of muscle cell differentiation (GO:0051149)3.08653889
93ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.08177265
94regulation of acyl-CoA biosynthetic process (GO:0050812)3.00166157
95regulation of calcium ion transmembrane transporter activity (GO:1901019)2.96864818
96regulation of calcium ion transmembrane transport (GO:1903169)2.96864818
97regulation of coenzyme metabolic process (GO:0051196)2.96384199
98regulation of cofactor metabolic process (GO:0051193)2.96384199
99regulation of ATP catabolic process (GO:1903289)2.92770152
100regulation of ATPase activity (GO:0043462)2.92770152
101pyrimidine ribonucleoside catabolic process (GO:0046133)2.89707562
102creatine metabolic process (GO:0006600)2.88254658
103mitochondrial fusion (GO:0008053)2.85207175
104cellular response to dexamethasone stimulus (GO:0071549)2.84476644
105negative regulation of monooxygenase activity (GO:0032769)2.78279534
106adult heart development (GO:0007512)2.78136619
107regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.77761126
108IMP biosynthetic process (GO:0006188)2.77409512
109muscle organ morphogenesis (GO:0048644)2.77292941
110mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.74966117
111striated muscle adaptation (GO:0014888)2.74388889
112cardiac muscle hypertrophy (GO:0003300)2.73816411
113negative regulation of cell size (GO:0045792)2.71671598
114telomere maintenance via semi-conservative replication (GO:0032201)2.71669237
115myoblast fusion (GO:0007520)2.70979296
116glycogen catabolic process (GO:0005980)2.70270330
117heart trabecula formation (GO:0060347)2.70181030
118transcription from mitochondrial promoter (GO:0006390)2.69239215
119muscle atrophy (GO:0014889)2.68343818
120striated muscle hypertrophy (GO:0014897)2.66151762
121skeletal muscle tissue development (GO:0007519)2.57450954
122apoptotic process involved in morphogenesis (GO:0060561)2.56824331
123ventricular cardiac muscle cell development (GO:0055015)2.55887980
124energy coupled proton transport, down electrochemical gradient (GO:0015985)2.53943513
125ATP synthesis coupled proton transport (GO:0015986)2.53943513
126membrane tubulation (GO:0097320)2.53467737
127epithelial cell-cell adhesion (GO:0090136)2.51438603
128syncytium formation by plasma membrane fusion (GO:0000768)2.50454990
129syncytium formation (GO:0006949)2.48844969
130muscle hypertrophy (GO:0014896)2.48718169
131muscle organ development (GO:0007517)2.47189074
132fatty acid transmembrane transport (GO:1902001)2.46823486
133DNA strand elongation involved in DNA replication (GO:0006271)2.45939036
134glucan catabolic process (GO:0009251)2.44453027
135neutrophil activation involved in immune response (GO:0002283)2.44035854
136cellular polysaccharide catabolic process (GO:0044247)2.43948061
137negative regulation of muscle hypertrophy (GO:0014741)2.43441087
138regulation of protein heterodimerization activity (GO:0043497)2.41770421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.87487164
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.86729152
3E2F7_22180533_ChIP-Seq_HELA_Human4.12991985
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.30623301
5GATA1_22025678_ChIP-Seq_K562_Human3.11885660
6ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.99579553
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.84172429
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.45818391
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.42962018
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.38635059
11PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse2.33898035
12VDR_21846776_ChIP-Seq_THP-1_Human2.32825869
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25405673
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.05153274
15MYC_22102868_ChIP-Seq_BL_Human1.94312817
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91125474
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91088061
18STAT3_1855785_ChIP-Seq_MESCs_Mouse1.88109552
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.85067500
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.84795652
21NFIB_24661679_ChIP-Seq_LUNG_Mouse1.83765995
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83645106
23CRX_20693478_ChIP-Seq_RETINA_Mouse1.81919287
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.75611730
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74494819
26ZNF263_19887448_ChIP-Seq_K562_Human1.73347833
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72030923
28CJUN_26792858_Chip-Seq_BT549_Human1.71187111
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70971376
30SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.70571789
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.69548417
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68346687
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65158725
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63549300
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.63406220
36BRD4_25478319_ChIP-Seq_HGPS_Human1.63013638
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62629435
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.61536972
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61328357
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60575117
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.60490344
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.59959062
43TBX20_22080862_ChIP-Seq_HEART_Mouse1.57708844
44TBX20_22328084_ChIP-Seq_HEART_Mouse1.57708844
45SMC3_22415368_ChIP-Seq_MEFs_Mouse1.56318492
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.55961673
47MAF_26560356_Chip-Seq_TH1_Human1.55504760
48TCF7_22412390_ChIP-Seq_EML_Mouse1.54060714
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53043008
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.49634993
51LXR_22292898_ChIP-Seq_THP-1_Human1.48467368
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48338731
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46889912
54* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46325155
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.46157452
56UTX_26944678_Chip-Seq_JUKART_Human1.45194445
57CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.44952838
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.44933222
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44885321
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44884545
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.43700704
62BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.43531466
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.42412768
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41438556
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38324054
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37608184
67NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35858757
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35208254
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34470155
70JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33710204
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33616054
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33423761
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32651602
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32327033
75EZH2_22144423_ChIP-Seq_EOC_Human1.31802806
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31730127
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29468336
78GATA4_21415370_ChIP-Seq_HL-1_Mouse1.28997691
79E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28793197
80SPI1_23127762_ChIP-Seq_K562_Human1.27398413
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26842799
82RUNX1_22412390_ChIP-Seq_EML_Mouse1.26199570
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26193896
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26193896
85SPI1_23547873_ChIP-Seq_NB4_Human1.26059880
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25848878
87SCL_19346495_ChIP-Seq_HPC-7_Human1.25713906
88KDM2B_26808549_Chip-Seq_DND41_Human1.25465943
89OCT4_21477851_ChIP-Seq_ESCs_Mouse1.25139285
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24637545
91E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23832990
92VDR_24763502_ChIP-Seq_THP-1_Human1.23579170
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23246984
94ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.23235959
95NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22473042
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21821902
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19555253
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19301137
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17297021
100* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.17070764
101SMC1_22415368_ChIP-Seq_MEFs_Mouse1.16232520
102SPI1_20517297_ChIP-Seq_HL60_Human1.16226264
103CTCF_21964334_Chip-Seq_Bcells_Human1.16016042
104FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15948599
105XRN2_22483619_ChIP-Seq_HELA_Human1.15102481
106BCL6_27268052_Chip-Seq_Bcells_Human1.13844618
107KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13328154
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13076926
109* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12865060
110SRF_21415370_ChIP-Seq_HL-1_Mouse1.11417816
111MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11284174
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11270507
113ATF3_27146783_Chip-Seq_COLON_Human1.11072889
114EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11050414
115CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10885554
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10350614
117MAF_26560356_Chip-Seq_TH2_Human1.10034740
118NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09231260
119TP53_23651856_ChIP-Seq_MEFs_Mouse1.08980296
120CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08950227
121NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08913694
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08846378
123YY1_22570637_ChIP-Seq_MALME-3M_Human1.08398465
124EST1_17652178_ChIP-ChIP_JURKAT_Human1.06952687
125PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06503946
126HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06351033
127TP53_18474530_ChIP-ChIP_U2OS_Human1.06068761
128* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05586505
129RACK7_27058665_Chip-Seq_MCF-7_Human1.04290037
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03610189
131JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03394318
132MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.02999190
133GATA2_21666600_ChIP-Seq_HMVEC_Human1.02992151
134STAT3_18555785_Chip-Seq_ESCs_Mouse1.02339827
135PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01728486
136* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01634457
137* CTCF_27219007_Chip-Seq_Bcells_Human1.00195623
138SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00159007
139TET1_21451524_ChIP-Seq_MESCs_Mouse1.00099161
140AR_21909140_ChIP-Seq_LNCAP_Human0.99848151
141ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99751833
142CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99418998
143STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98754843
144* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98524828
145ESR1_20079471_ChIP-ChIP_T-47D_Human0.98279562
146EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98102023
147PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98094778
148BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97836177
149* ZFX_18555785_Chip-Seq_ESCs_Mouse0.97571517
150GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97244024
151* P53_22387025_ChIP-Seq_ESCs_Mouse0.96812416
152IRF8_21731497_ChIP-ChIP_J774_Mouse0.96588767
153TFEB_21752829_ChIP-Seq_HELA_Human0.96481871
154THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95915867
155CSB_26484114_Chip-Seq_FIBROBLAST_Human0.94442722
156ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93545962
157NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93506447
158PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93397126
159CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92792735
160KDM2B_26808549_Chip-Seq_REH_Human0.92567376
161NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92118383
162NFI_21473784_ChIP-Seq_ESCs_Mouse0.91941425
163IGF1R_20145208_ChIP-Seq_DFB_Human0.91006142
164SMAD1_18555785_Chip-Seq_ESCs_Mouse0.89209083
165SOX2_18555785_Chip-Seq_ESCs_Mouse0.87135243
166IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86906659
167CBP_20019798_ChIP-Seq_JUKART_Human0.86906659
168KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86699281
169* PU1_27457419_Chip-Seq_LIVER_Mouse0.86057032
170MTF2_20144788_ChIP-Seq_MESCs_Mouse0.85802745
171ESR2_21235772_ChIP-Seq_MCF-7_Human0.85312220
172CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84506619
173SA1_22415368_ChIP-Seq_MEFs_Mouse0.84461271
174EZH2_27294783_Chip-Seq_ESCs_Mouse0.83972788
175EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82786065
176CLOCK_20551151_ChIP-Seq_293T_Human0.82414430
177HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81317123
178PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81182751
179ZNF274_21170338_ChIP-Seq_K562_Hela0.80725290
180P53_22127205_ChIP-Seq_FIBROBLAST_Human0.80115912
181LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79989152
182PIAS1_25552417_ChIP-Seq_VCAP_Human0.76576537

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy5.10443527
2MP0000749_muscle_degeneration5.09230114
3MP0003646_muscle_fatigue4.75747795
4MP0002837_dystrophic_cardiac_calcinosis4.36910724
5MP0004084_abnormal_cardiac_muscle3.86752906
6MP0004145_abnormal_muscle_electrophysio3.76507707
7MP0000750_abnormal_muscle_regeneration3.72274544
8MP0004036_abnormal_muscle_relaxation3.34969238
9MP0002106_abnormal_muscle_physiology3.22734981
10MP0004087_abnormal_muscle_fiber3.13853705
11MP0002269_muscular_atrophy3.05117401
12MP0005330_cardiomyopathy3.00189677
13MP0000747_muscle_weakness2.97959960
14MP0000759_abnormal_skeletal_muscle2.74588650
15MP0005369_muscle_phenotype2.57874930
16MP0004215_abnormal_myocardial_fiber2.56674421
17MP0004270_analgesia2.56492423
18MP0000733_abnormal_muscle_development2.19732711
19MP0004233_abnormal_muscle_weight2.14696724
20MP0005620_abnormal_muscle_contractility2.14664235
21MP0003828_pulmonary_edema2.01424952
22MP0010630_abnormal_cardiac_muscle1.99459022
23MP0002972_abnormal_cardiac_muscle1.96777759
24MP0003950_abnormal_plasma_membrane1.77243077
25MP0009780_abnormal_chondrocyte_physiolo1.76672376
26MP0004130_abnormal_muscle_cell1.76100132
27MP0003137_abnormal_impulse_conducting1.66937792
28MP0002332_abnormal_exercise_endurance1.64582232
29MP0001544_abnormal_cardiovascular_syste1.64206627
30MP0005385_cardiovascular_system_phenoty1.64206627
31MP0001542_abnormal_bone_strength1.63761987
32MP0002877_abnormal_melanocyte_morpholog1.55391719
33MP0000343_altered_response_to1.52829161
34MP0003566_abnormal_cell_adhesion1.51641653
35MP0008775_abnormal_heart_ventricle1.51534536
36MP0000013_abnormal_adipose_tissue1.44751901
37MP0006036_abnormal_mitochondrial_physio1.43984783
38MP0003221_abnormal_cardiomyocyte_apopto1.43003841
39MP0000372_irregular_coat_pigmentation1.40262861
40MP0001299_abnormal_eye_distance/1.33404642
41MP0002108_abnormal_muscle_morphology1.25699718
42MP0004484_altered_response_of1.20722851
43MP0003279_aneurysm1.18576192
44MP0003045_fibrosis1.17553014
45MP0006138_congestive_heart_failure1.16228609
46MP0010030_abnormal_orbit_morphology1.11777873
47MP0003567_abnormal_fetal_cardiomyocyte1.10812677
48MP0008438_abnormal_cutaneous_collagen1.10447694
49MP0002127_abnormal_cardiovascular_syste1.04068289
50MP0001661_extended_life_span1.01731028
51MP0005266_abnormal_metabolism1.01440751
52MP0003705_abnormal_hypodermis_morpholog1.01321474
53MP0004510_myositis0.99819685
54MP0005171_absent_coat_pigmentation0.98232811
55MP0005058_abnormal_lysosome_morphology0.98005015
56MP0001853_heart_inflammation0.91701410
57MP0010094_abnormal_chromosome_stability0.91005064
58MP0004957_abnormal_blastocyst_morpholog0.86858106
59MP0005360_urolithiasis0.86792068
60MP0000266_abnormal_heart_morphology0.85693812
61MP0000371_diluted_coat_color0.83936064
62MP0003959_abnormal_lean_body0.83000306
63MP0001346_abnormal_lacrimal_gland0.82721599
64MP0008057_abnormal_DNA_replication0.80657105
65MP0004808_abnormal_hematopoietic_stem0.80438572
66MP0002396_abnormal_hematopoietic_system0.78794510
67MP0003077_abnormal_cell_cycle0.78105418
68MP0004185_abnormal_adipocyte_glucose0.76853374
69MP0005666_abnormal_adipose_tissue0.76295249
70MP0004272_abnormal_basement_membrane0.75892155
71MP0008007_abnormal_cellular_replicative0.75694940
72MP0009278_abnormal_bone_marrow0.75462288
73MP0004858_abnormal_nervous_system0.74779727
74MP0000767_abnormal_smooth_muscle0.74339297
75MP0002148_abnormal_hypersensitivity_rea0.74295654
76MP0010352_gastrointestinal_tract_polyps0.74225126
77MP0002234_abnormal_pharynx_morphology0.72474651
78MP0005023_abnormal_wound_healing0.72430075
79MP0000762_abnormal_tongue_morphology0.72093133
80MP0005464_abnormal_platelet_physiology0.71762627
81MP0003436_decreased_susceptibility_to0.71749086
82MP0001958_emphysema0.71639966
83MP0004085_abnormal_heartbeat0.71516272
84MP0006082_CNS_inflammation0.70985465
85MP0001545_abnormal_hematopoietic_system0.68187094
86MP0005397_hematopoietic_system_phenotyp0.68187094
87MP0002405_respiratory_system_inflammati0.68134050
88MP0003763_abnormal_thymus_physiology0.67563942
89MP0000003_abnormal_adipose_tissue0.67323129
90MP0000858_altered_metastatic_potential0.66062378
91MP0002896_abnormal_bone_mineralization0.66023764
92MP0002128_abnormal_blood_circulation0.64496627
93MP0003111_abnormal_nucleus_morphology0.64005660
94MP0000015_abnormal_ear_pigmentation0.63893688
95MP0005165_increased_susceptibility_to0.63489654
96MP0005671_abnormal_response_to0.62709771
97MP0002114_abnormal_axial_skeleton0.62532531
98MP0004883_abnormal_blood_vessel0.62015124
99MP0002734_abnormal_mechanical_nocicepti0.61107594
100MP0006035_abnormal_mitochondrial_morpho0.61058121
101MP0001835_abnormal_antigen_presentation0.58313090
102MP0005075_abnormal_melanosome_morpholog0.57082660
103MP0003191_abnormal_cellular_cholesterol0.55285622
104MP0003172_abnormal_lysosome_physiology0.55264877
105MP0005623_abnormal_meninges_morphology0.53541482
106MP0002019_abnormal_tumor_incidence0.52636811
107MP0002722_abnormal_immune_system0.52136101
108MP0003656_abnormal_erythrocyte_physiolo0.52062360
109MP0002933_joint_inflammation0.52016506
110MP0008770_decreased_survivor_rate0.51865932
111MP0003806_abnormal_nucleotide_metabolis0.51713728
112MP0005174_abnormal_tail_pigmentation0.51431691
113MP0002971_abnormal_brown_adipose0.51123491
114MP0005595_abnormal_vascular_smooth0.51007158
115MP0002168_other_aberrant_phenotype0.50935905
116MP0000689_abnormal_spleen_morphology0.50620045
117MP0000313_abnormal_cell_death0.50360007
118MP0002075_abnormal_coat/hair_pigmentati0.49333026
119MP0009785_altered_susceptibility_to0.49274191
120MP0009250_abnormal_appendicular_skeleto0.49232376
121MP0005000_abnormal_immune_tolerance0.49150648
122MP0002398_abnormal_bone_marrow0.49054670
123MP0003693_abnormal_embryo_hatching0.48840638
124MP0005451_abnormal_body_composition0.48387222
125MP0005275_abnormal_skin_tensile0.47037927
126MP0002089_abnormal_postnatal_growth/wei0.40424064
127MP0002249_abnormal_larynx_morphology0.39577581
128MP0002822_catalepsy0.39434155
129MP0004134_abnormal_chest_morphology0.39316772
130MP0005452_abnormal_adipose_tissue0.36663881
131MP0009384_cardiac_valve_regurgitation0.35666472
132MP0003091_abnormal_cell_migration0.35527852
133MP0002184_abnormal_innervation0.35504314
134MP0004142_abnormal_muscle_tone0.33640423
135MP0000230_abnormal_systemic_arterial0.32672034
136MP0001986_abnormal_taste_sensitivity0.32610444
137MP0005375_adipose_tissue_phenotype0.31270260
138MP0008789_abnormal_olfactory_epithelium0.31181362
139MP0005376_homeostasis/metabolism_phenot0.30940502
140* MP0001943_abnormal_respiration0.28497801
141MP0005319_abnormal_enzyme/_coenzyme0.27939399
142MP0003879_abnormal_hair_cell0.26626271
143MP0002932_abnormal_joint_morphology0.23903541
144MP0006054_spinal_hemorrhage0.21617027
145MP0002113_abnormal_skeleton_development0.21494225
146MP0003385_abnormal_body_wall0.21058078

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.95925646
2Muscle fiber inclusion bodies (HP:0100299)6.92069558
3Nemaline bodies (HP:0003798)6.17603128
4Exercise-induced muscle cramps (HP:0003710)5.94884060
5Exercise-induced myalgia (HP:0003738)5.83409315
6Muscle fiber splitting (HP:0003555)5.62453719
7Type 1 muscle fiber predominance (HP:0003803)5.40537262
8Calf muscle hypertrophy (HP:0008981)5.27308895
9Muscle hypertrophy of the lower extremities (HP:0008968)5.16716301
10Difficulty running (HP:0009046)5.00537621
11Abnormality of the calf musculature (HP:0001430)4.76261258
12Hyporeflexia of lower limbs (HP:0002600)4.75683160
13Increased connective tissue (HP:0009025)4.58225882
14Sudden death (HP:0001699)4.53411653
15EMG: myopathic abnormalities (HP:0003458)4.51370709
16Distal arthrogryposis (HP:0005684)4.51071630
17Difficulty climbing stairs (HP:0003551)4.48930466
18* Type 2 muscle fiber atrophy (HP:0003554)4.11805543
19Ulnar deviation of the wrist (HP:0003049)4.09624790
20Ventricular tachycardia (HP:0004756)3.99249805
21Myopathic facies (HP:0002058)3.97305153
22Fetal akinesia sequence (HP:0001989)3.97039278
23Abnormality of the left ventricular outflow tract (HP:0011103)3.92955231
24Subaortic stenosis (HP:0001682)3.92955231
25* Muscle fiber atrophy (HP:0100295)3.88139397
26* Fatigable weakness (HP:0003473)3.85722829
27* Abnormality of the neuromuscular junction (HP:0003398)3.85722829
28Myoglobinuria (HP:0002913)3.83182527
29Myotonia (HP:0002486)3.78669862
30* Malignant hyperthermia (HP:0002047)3.77721633
31Round ear (HP:0100830)3.74105020
32Neck muscle weakness (HP:0000467)3.71489775
33Asymmetric septal hypertrophy (HP:0001670)3.71412283
34Rhabdomyolysis (HP:0003201)3.37000325
35* Weak cry (HP:0001612)3.36382139
36Bulbar palsy (HP:0001283)3.31615943
37Lipoatrophy (HP:0100578)3.31010678
38Abnormality of skeletal muscle fiber size (HP:0012084)3.28177053
39* Gowers sign (HP:0003391)3.24084460
40Aplasia of the musculature (HP:0100854)3.17962620
41Calcaneovalgus deformity (HP:0001848)3.13128849
42Muscle stiffness (HP:0003552)3.07072324
43* Pterygium (HP:0001059)3.06827588
44Mildly elevated creatine phosphokinase (HP:0008180)3.04008727
45* Popliteal pterygium (HP:0009756)2.95034504
46* Easy fatigability (HP:0003388)2.94543411
47Generalized muscle weakness (HP:0003324)2.94378975
48Atrial fibrillation (HP:0005110)2.93652794
49Distal lower limb muscle weakness (HP:0009053)2.90406312
50Increased variability in muscle fiber diameter (HP:0003557)2.89824876
51Distal lower limb amyotrophy (HP:0008944)2.88577426
52EMG: neuropathic changes (HP:0003445)2.85287281
53* Amniotic constriction ring (HP:0009775)2.79925887
54* Abnormality of placental membranes (HP:0011409)2.79925887
55Deformed tarsal bones (HP:0008119)2.77879778
56Rimmed vacuoles (HP:0003805)2.74685566
57Primary atrial arrhythmia (HP:0001692)2.74207067
58Supraventricular tachycardia (HP:0004755)2.70906874
59Dilated cardiomyopathy (HP:0001644)2.69653836
60Areflexia of lower limbs (HP:0002522)2.64783387
61Supraventricular arrhythmia (HP:0005115)2.63687214
62Limb-girdle muscle atrophy (HP:0003797)2.62761511
63Right ventricular cardiomyopathy (HP:0011663)2.59370960
64Long clavicles (HP:0000890)2.54712605
65Absent phalangeal crease (HP:0006109)2.53973026
66Palpitations (HP:0001962)2.48136098
67Progressive muscle weakness (HP:0003323)2.46747774
68Centrally nucleated skeletal muscle fibers (HP:0003687)2.40458464
69Scapular winging (HP:0003691)2.37046541
70Frequent falls (HP:0002359)2.29779605
71Testicular atrophy (HP:0000029)2.22006187
72Akinesia (HP:0002304)2.15536431
73* Respiratory insufficiency due to muscle weakness (HP:0002747)2.10882400
74Muscular dystrophy (HP:0003560)2.10602845
75Metatarsus adductus (HP:0001840)2.09529845
76Facial diplegia (HP:0001349)2.08909428
77Ventricular arrhythmia (HP:0004308)2.05234853
78Hip contracture (HP:0003273)2.04897497
79* Cystic hygroma (HP:0000476)2.03308958
80Aplasia/Hypoplasia involving the musculature (HP:0001460)2.00850013
81Abnormality of the calcaneus (HP:0008364)2.00102166
82Abnormal finger flexion creases (HP:0006143)1.97750944
83Waddling gait (HP:0002515)1.97649425
84Spinal rigidity (HP:0003306)1.97129372
85Hypoplastic heart (HP:0001961)1.93328422
86Proximal amyotrophy (HP:0007126)1.92116116
87* Thin ribs (HP:0000883)1.91436552
88Limited hip movement (HP:0008800)1.90987148
89Bundle branch block (HP:0011710)1.89315559
90Lower limb amyotrophy (HP:0007210)1.87778320
91Abnormal atrioventricular conduction (HP:0005150)1.85185656
92* Generalized amyotrophy (HP:0003700)1.84095764
93Slender build (HP:0001533)1.82005333
94Poor suck (HP:0002033)1.81558421
95* Nonprogressive disorder (HP:0003680)1.81150995
96Abnormality of the hip-girdle musculature (HP:0001445)1.79188068
97Abnormality of the musculature of the pelvis (HP:0001469)1.79188068
98Limb-girdle muscle weakness (HP:0003325)1.76983104
99Abnormality of the shoulder girdle musculature (HP:0001435)1.76392641
100Trismus (HP:0000211)1.75873512
101Breech presentation (HP:0001623)1.74064503
102Abnormality of the foot musculature (HP:0001436)1.73793549
103Heart block (HP:0012722)1.72655129
104Pelvic girdle muscle weakness (HP:0003749)1.72121160
105Diminished movement (HP:0002374)1.71972302
106Atrioventricular block (HP:0001678)1.71723017
107* Arthrogryposis multiplex congenita (HP:0002804)1.70615636
108Foot dorsiflexor weakness (HP:0009027)1.70105909
109Multiple enchondromatosis (HP:0005701)1.67951392
110Aortic aneurysm (HP:0004942)1.67728260
111Delayed gross motor development (HP:0002194)1.67563284
112Hypoplastic ischia (HP:0003175)1.65679579
113* Abnormalities of placenta or umbilical cord (HP:0001194)1.64262926
114Increased density of long bones (HP:0006392)1.61000105
115* Webbed neck (HP:0000465)1.59476340
116Left ventricular hypertrophy (HP:0001712)1.54186244
117Protrusio acetabuli (HP:0003179)1.49370529
118Infantile muscular hypotonia (HP:0008947)1.40685653

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.19492119
2OBSCN4.66444994
3MUSK4.46522235
4TRIB32.95666972
5PHKG22.87451478
6PHKG12.87451478
7MOS2.54139589
8NEK12.25397522
9PDK32.16993180
10PDK42.16993180
11PKN22.12713015
12CCNB12.08183457
13PIM22.02470596
14PIK3CG2.00350444
15KDR1.89457213
16NME21.89009412
17MAPKAPK31.84102355
18MYLK1.50032386
19MAP4K11.48096677
20MAP3K111.43387108
21PDK21.40785346
22ILK1.39434902
23TRPM71.34361970
24TGFBR21.32305499
25DMPK1.32050941
26MAP2K31.32008499
27PINK11.30002713
28ICK1.25986860
29NEK91.22873800
30NME11.18754895
31STK241.17196119
32MATK1.13743023
33MAP3K121.13374387
34PAK41.08056976
35TESK21.06136239
36CDK81.02824302
37MAP2K11.01205838
38GRK71.00257220
39LMTK20.98547922
40KIT0.96904274
41TAOK20.96744636
42MAPK120.95499179
43BCKDK0.93071897
44MAPK110.87077072
45BMX0.85052442
46BLK0.84460479
47LRRK20.83175417
48BUB10.81550057
49STK100.80338122
50RPS6KB20.78344234
51ERN10.78301391
52EEF2K0.73430588
53CAMK2G0.72441892
54LIMK10.71755122
55RIPK10.70581293
56MAP3K100.68771155
57MAPK70.67538965
58STK160.66282023
59CDK120.66126637
60WEE10.65259778
61CDK70.64792857
62AKT20.64296176
63RPS6KL10.62921870
64RPS6KC10.62921870
65CAMK2D0.62837353
66PAK60.61844467
67TBK10.60060045
68MAP3K70.59574256
69MST1R0.59444742
70DDR20.59119097
71PDGFRA0.56843563
72MELK0.56729932
73ZAP700.54495868
74RPS6KA60.53595297
75ROCK10.53435694
76PIM10.53388731
77TESK10.53155710
78CDC70.51738287
79DAPK30.50190143
80DAPK20.49841383
81PRKD10.48948665
82DYRK1B0.48929902
83PRKG20.48885029
84MAP3K60.47921600
85PRKAA10.47591656
86CDK60.46696537
87CSK0.46597474
88AURKB0.45327217
89VRK20.44579496
90MAP3K50.42960120
91MARK10.41048932
92STK40.39929142
93ARAF0.39702873
94CDK40.39104509
95SCYL20.38562564
96MAPKAPK20.38225847
97BTK0.38220545
98TTK0.37988634
99TXK0.37910221
100PRKACB0.37850236
101PRKG10.37591617
102ERBB30.37185710
103CAMK2A0.36749347
104MAP3K30.36589712
105EIF2AK30.36450530
106MTOR0.36301181
107SIK10.35622029
108PTK2B0.34391004
109RPS6KA10.33845162
110PRKAA20.33736457
111BRSK20.32129027
112ROCK20.30959870
113MAP3K130.30644930
114CAMK2B0.30284277
115CSF1R0.30211167
116FLT30.28636730
117MAPK40.27684189
118MAP3K80.26304122
119TGFBR10.25295065
120PRKD20.25259494
121CDK190.24772420
122PAK20.24600705
123ITK0.24408883
124PLK10.24130035
125PIK3CA0.23884636
126AURKA0.23157173
127FGFR40.22423927
128MAP2K40.22349316
129CDK11A0.21801134
130MAPKAPK50.21443887
131ABL10.20684613
132PBK0.19395006
133PLK20.18912790
134CDK150.18311723
135PAK30.17751436
136MAPK130.17738608
137MAP2K60.17028259
138PRKACA0.16392339
139RPS6KA30.15303004
140FER0.14483555
141CDK180.13962297
142CDK140.13378077
143ABL20.13134674
144MAPK100.13059429
145PTK20.12309646
146TNK20.11976415
147EIF2AK10.11544465
148LATS20.11514991
149PAK10.11447785
150SGK30.10952571
151RPS6KB10.10867508
152CDC42BPA0.10811948
153DAPK10.10788144
154MARK20.09344692
155CDK90.08755948

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.07159860
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.60269417
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.27193548
4Cardiac muscle contraction_Homo sapiens_hsa042603.22172215
5Dilated cardiomyopathy_Homo sapiens_hsa054143.21980077
6DNA replication_Homo sapiens_hsa030302.78184130
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.42433874
8Parkinsons disease_Homo sapiens_hsa050122.31866913
9Viral myocarditis_Homo sapiens_hsa054162.23177819
10Circadian rhythm_Homo sapiens_hsa047102.20658473
11Mismatch repair_Homo sapiens_hsa034302.14932593
12Oxidative phosphorylation_Homo sapiens_hsa001902.01440300
13Base excision repair_Homo sapiens_hsa034101.90274237
14Carbon metabolism_Homo sapiens_hsa012001.89501438
15Ribosome_Homo sapiens_hsa030101.83251753
16Oxytocin signaling pathway_Homo sapiens_hsa049211.77541124
17Proteasome_Homo sapiens_hsa030501.69663822
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.65329858
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.63899220
20Alzheimers disease_Homo sapiens_hsa050101.53976820
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.52583453
22Calcium signaling pathway_Homo sapiens_hsa040201.52235378
23Nucleotide excision repair_Homo sapiens_hsa034201.51940131
24Biosynthesis of amino acids_Homo sapiens_hsa012301.45329712
25Huntingtons disease_Homo sapiens_hsa050161.43958890
26Tight junction_Homo sapiens_hsa045301.43227242
27Other glycan degradation_Homo sapiens_hsa005111.40369195
28Galactose metabolism_Homo sapiens_hsa000521.33799193
29Fructose and mannose metabolism_Homo sapiens_hsa000511.30720531
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24787843
31Homologous recombination_Homo sapiens_hsa034401.21271709
32Propanoate metabolism_Homo sapiens_hsa006401.19688608
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15886966
34Arginine biosynthesis_Homo sapiens_hsa002201.15514111
35HIF-1 signaling pathway_Homo sapiens_hsa040661.09179570
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.08685689
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02156027
38RNA transport_Homo sapiens_hsa030131.01473803
39RNA polymerase_Homo sapiens_hsa030201.00221403
40Vascular smooth muscle contraction_Homo sapiens_hsa042700.99886093
41Focal adhesion_Homo sapiens_hsa045100.98378760
42Glycosaminoglycan degradation_Homo sapiens_hsa005310.98267609
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97984858
44Starch and sucrose metabolism_Homo sapiens_hsa005000.94735903
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94655546
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91386857
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88969080
48Cell cycle_Homo sapiens_hsa041100.88781153
49Pyruvate metabolism_Homo sapiens_hsa006200.87894592
50Insulin signaling pathway_Homo sapiens_hsa049100.86241988
51Leishmaniasis_Homo sapiens_hsa051400.85745002
52Renin secretion_Homo sapiens_hsa049240.85710784
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85553668
54Fatty acid degradation_Homo sapiens_hsa000710.83772064
55Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82748674
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82130719
57Platelet activation_Homo sapiens_hsa046110.78819508
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77476514
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77100714
60Legionellosis_Homo sapiens_hsa051340.76747337
61Fatty acid metabolism_Homo sapiens_hsa012120.75569075
62Asthma_Homo sapiens_hsa053100.75018118
63Hematopoietic cell lineage_Homo sapiens_hsa046400.74498457
64Glucagon signaling pathway_Homo sapiens_hsa049220.73348322
65Antigen processing and presentation_Homo sapiens_hsa046120.72772012
66Primary immunodeficiency_Homo sapiens_hsa053400.72547750
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72039546
68Salmonella infection_Homo sapiens_hsa051320.71587917
69Spliceosome_Homo sapiens_hsa030400.71077946
70Apoptosis_Homo sapiens_hsa042100.70597301
71Lysosome_Homo sapiens_hsa041420.70258871
72mTOR signaling pathway_Homo sapiens_hsa041500.68709262
73p53 signaling pathway_Homo sapiens_hsa041150.68309908
74Pentose phosphate pathway_Homo sapiens_hsa000300.68255824
75FoxO signaling pathway_Homo sapiens_hsa040680.66872595
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.63017453
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.61323309
78Insulin resistance_Homo sapiens_hsa049310.60959854
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60284367
80VEGF signaling pathway_Homo sapiens_hsa043700.58918398
81MAPK signaling pathway_Homo sapiens_hsa040100.58213328
82Pyrimidine metabolism_Homo sapiens_hsa002400.58109544
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57579101
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56936874
85Adherens junction_Homo sapiens_hsa045200.56778376
86HTLV-I infection_Homo sapiens_hsa051660.56499743
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54487232
88ECM-receptor interaction_Homo sapiens_hsa045120.54304392
89Small cell lung cancer_Homo sapiens_hsa052220.53057458
90Acute myeloid leukemia_Homo sapiens_hsa052210.53013412
91RNA degradation_Homo sapiens_hsa030180.52263374
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50866076
93Notch signaling pathway_Homo sapiens_hsa043300.50839584
94Fatty acid elongation_Homo sapiens_hsa000620.50146479
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48826245
96Amoebiasis_Homo sapiens_hsa051460.47622829
97Epstein-Barr virus infection_Homo sapiens_hsa051690.47242592
98B cell receptor signaling pathway_Homo sapiens_hsa046620.46491036
99Shigellosis_Homo sapiens_hsa051310.46108515
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45940879
101Malaria_Homo sapiens_hsa051440.45819142
102Thyroid cancer_Homo sapiens_hsa052160.44667989
103Measles_Homo sapiens_hsa051620.44356232
104Salivary secretion_Homo sapiens_hsa049700.43916040
105Osteoclast differentiation_Homo sapiens_hsa043800.43796254
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42958591
107Proteoglycans in cancer_Homo sapiens_hsa052050.42826278
108Fatty acid biosynthesis_Homo sapiens_hsa000610.42455327
109AMPK signaling pathway_Homo sapiens_hsa041520.41632476
110Bladder cancer_Homo sapiens_hsa052190.41606660
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41539918
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40951306
113Viral carcinogenesis_Homo sapiens_hsa052030.40880776
114Gastric acid secretion_Homo sapiens_hsa049710.40409564
115Chronic myeloid leukemia_Homo sapiens_hsa052200.40331508
116Arginine and proline metabolism_Homo sapiens_hsa003300.39767135
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.39135258
118Tuberculosis_Homo sapiens_hsa051520.38167656
119Renin-angiotensin system_Homo sapiens_hsa046140.36912410
120Nitrogen metabolism_Homo sapiens_hsa009100.36666063
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35711336
122Sulfur relay system_Homo sapiens_hsa041220.35394469
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.35379428
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35338238
125Toxoplasmosis_Homo sapiens_hsa051450.35140972
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35069122
127Gap junction_Homo sapiens_hsa045400.34518217
128Lysine degradation_Homo sapiens_hsa003100.33750637
129Melanoma_Homo sapiens_hsa052180.32807204
130GnRH signaling pathway_Homo sapiens_hsa049120.32537133
131Sulfur metabolism_Homo sapiens_hsa009200.30680172
132Protein digestion and absorption_Homo sapiens_hsa049740.30104237
133beta-Alanine metabolism_Homo sapiens_hsa004100.29483146
134Long-term potentiation_Homo sapiens_hsa047200.29128270
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23722345
136TGF-beta signaling pathway_Homo sapiens_hsa043500.23344179
137Peroxisome_Homo sapiens_hsa041460.23325530
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23064427
139Butanoate metabolism_Homo sapiens_hsa006500.23011230
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20588246
141Aldosterone synthesis and secretion_Homo sapiens_hsa049250.18876959
142Tryptophan metabolism_Homo sapiens_hsa003800.18237415
143Glioma_Homo sapiens_hsa052140.17201968
144Circadian entrainment_Homo sapiens_hsa047130.14975810
145Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.13856164
146Purine metabolism_Homo sapiens_hsa002300.13538125
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13504876
148Hippo signaling pathway_Homo sapiens_hsa043900.13484913
149Folate biosynthesis_Homo sapiens_hsa007900.11747598
150Glutathione metabolism_Homo sapiens_hsa004800.11728232
151Histidine metabolism_Homo sapiens_hsa003400.11362624
152Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.08520475
153Endocytosis_Homo sapiens_hsa041440.08212968

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »