RARRES2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.90368463
2L-phenylalanine catabolic process (GO:0006559)6.90368463
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.58682319
4L-phenylalanine metabolic process (GO:0006558)6.58682319
5aromatic amino acid family catabolic process (GO:0009074)6.16445935
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.11180815
7epoxygenase P450 pathway (GO:0019373)5.53277469
8indole-containing compound catabolic process (GO:0042436)5.49369257
9indolalkylamine catabolic process (GO:0046218)5.49369257
10tryptophan catabolic process (GO:0006569)5.49369257
11bile acid biosynthetic process (GO:0006699)5.46682984
12regulation of protein activation cascade (GO:2000257)5.38470244
13alpha-linolenic acid metabolic process (GO:0036109)5.34870858
14kynurenine metabolic process (GO:0070189)5.33659173
15glyoxylate metabolic process (GO:0046487)5.31464006
16high-density lipoprotein particle remodeling (GO:0034375)5.28102147
17negative regulation of fibrinolysis (GO:0051918)5.23596570
18complement activation, alternative pathway (GO:0006957)5.23353869
19tryptophan metabolic process (GO:0006568)5.16170986
20cysteine metabolic process (GO:0006534)5.15267897
21regulation of complement activation (GO:0030449)5.12043182
22regulation of apoptotic cell clearance (GO:2000425)5.11570747
23exogenous drug catabolic process (GO:0042738)5.09895565
24regulation of fibrinolysis (GO:0051917)5.07979101
25protein carboxylation (GO:0018214)5.07243766
26peptidyl-glutamic acid carboxylation (GO:0017187)5.07243766
27sulfur amino acid catabolic process (GO:0000098)5.06910340
28urea metabolic process (GO:0019627)5.05825140
29urea cycle (GO:0000050)5.05825140
30regulation of triglyceride catabolic process (GO:0010896)4.89395395
31omega-hydroxylase P450 pathway (GO:0097267)4.88690644
32ethanol metabolic process (GO:0006067)4.80543680
33regulation of cholesterol esterification (GO:0010872)4.77228184
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.72394155
35reverse cholesterol transport (GO:0043691)4.71767241
36serine family amino acid catabolic process (GO:0009071)4.68583253
37nitrogen cycle metabolic process (GO:0071941)4.68016486
38bile acid metabolic process (GO:0008206)4.67201897
39plasma lipoprotein particle remodeling (GO:0034369)4.64537533
40protein-lipid complex remodeling (GO:0034368)4.64537533
41macromolecular complex remodeling (GO:0034367)4.64537533
42triglyceride homeostasis (GO:0070328)4.50618839
43acylglycerol homeostasis (GO:0055090)4.50618839
44amino-acid betaine metabolic process (GO:0006577)4.49586597
45drug metabolic process (GO:0017144)4.46271486
46plasma lipoprotein particle clearance (GO:0034381)4.45011649
47homocysteine metabolic process (GO:0050667)4.44611391
48aromatic amino acid family metabolic process (GO:0009072)4.43045940
49phospholipid efflux (GO:0033700)4.38229929
50tyrosine metabolic process (GO:0006570)4.37959726
51alpha-amino acid catabolic process (GO:1901606)4.29093593
52lysine metabolic process (GO:0006553)4.23432979
53lysine catabolic process (GO:0006554)4.23432979
54negative regulation of protein activation cascade (GO:2000258)4.21842431
55negative regulation of blood coagulation (GO:0030195)4.21581196
56negative regulation of hemostasis (GO:1900047)4.21581196
57cellular ketone body metabolic process (GO:0046950)4.19279752
58negative regulation of cholesterol transport (GO:0032375)4.17707025
59negative regulation of sterol transport (GO:0032372)4.17707025
60imidazole-containing compound metabolic process (GO:0052803)4.09162613
61fibrinolysis (GO:0042730)4.07281665
62phenylpropanoid metabolic process (GO:0009698)4.07005779
63regulation of humoral immune response (GO:0002920)4.05103262
64cellular glucuronidation (GO:0052695)4.04159243
65glucocorticoid biosynthetic process (GO:0006704)4.01737099
66acute-phase response (GO:0006953)3.99299152
67bile acid and bile salt transport (GO:0015721)3.98037855
68cellular amino acid catabolic process (GO:0009063)3.97054120
69low-density lipoprotein particle remodeling (GO:0034374)3.95358587
70coenzyme catabolic process (GO:0009109)3.94739264
71cholesterol efflux (GO:0033344)3.93462719
72negative regulation of coagulation (GO:0050819)3.91989891
73opsonization (GO:0008228)3.91008023
74indolalkylamine metabolic process (GO:0006586)3.85193867
75glutamate metabolic process (GO:0006536)3.84773970
76negative regulation of wound healing (GO:0061045)3.84678825
77ethanol oxidation (GO:0006069)3.84389841
78blood coagulation, intrinsic pathway (GO:0007597)3.82857628
79amine catabolic process (GO:0009310)3.82025438
80cellular biogenic amine catabolic process (GO:0042402)3.82025438
81benzene-containing compound metabolic process (GO:0042537)3.80322566
82positive regulation of lipid catabolic process (GO:0050996)3.79513181
83plasma lipoprotein particle assembly (GO:0034377)3.79224203
84negative regulation of lipase activity (GO:0060192)3.76870261
85complement activation (GO:0006956)3.72948690
86positive regulation of fatty acid beta-oxidation (GO:0032000)3.72864358
87glycine metabolic process (GO:0006544)3.72018770
88serine family amino acid metabolic process (GO:0009069)3.71109342
89cellular modified amino acid catabolic process (GO:0042219)3.71027157
90complement activation, classical pathway (GO:0006958)3.70026662
91protein activation cascade (GO:0072376)3.68628611
92positive regulation of fatty acid biosynthetic process (GO:0045723)3.67628400
93phospholipid homeostasis (GO:0055091)3.63433446
94positive regulation of triglyceride lipase activity (GO:0061365)3.63411378
95positive regulation of lipoprotein lipase activity (GO:0051006)3.63411378
96short-chain fatty acid metabolic process (GO:0046459)3.62754194
97arginine metabolic process (GO:0006525)3.62431121
98ketone body metabolic process (GO:1902224)3.62208602
99glucuronate metabolic process (GO:0019585)3.61786519
100uronic acid metabolic process (GO:0006063)3.61786519
101drug catabolic process (GO:0042737)3.60169993
102regulation of lipoprotein particle clearance (GO:0010984)3.59784316
103aldehyde catabolic process (GO:0046185)3.59263591
104NADH metabolic process (GO:0006734)3.57896430
105organic acid catabolic process (GO:0016054)3.57836537
106carboxylic acid catabolic process (GO:0046395)3.57836537
107negative regulation of complement activation (GO:0045916)3.57796509
108primary alcohol catabolic process (GO:0034310)3.54973952
109plasma lipoprotein particle organization (GO:0071827)3.54175692
110oxidative demethylation (GO:0070989)3.53018886
111cholesterol homeostasis (GO:0042632)3.52301423
112fatty acid oxidation (GO:0019395)3.51663379
113dicarboxylic acid biosynthetic process (GO:0043650)3.51189786
114fatty acid beta-oxidation (GO:0006635)3.51038719
115very-low-density lipoprotein particle assembly (GO:0034379)3.49394925
116positive regulation of blood coagulation (GO:0030194)3.49123869
117positive regulation of hemostasis (GO:1900048)3.49123869
118carnitine metabolic process (GO:0009437)3.48949153
119triglyceride catabolic process (GO:0019433)3.48501834
120lipid oxidation (GO:0034440)3.47877893
121regulation of plasminogen activation (GO:0010755)3.47449872
122acetyl-CoA metabolic process (GO:0006084)3.46998313
123L-serine metabolic process (GO:0006563)3.43154667
124acylglycerol catabolic process (GO:0046464)3.40353857
125neutral lipid catabolic process (GO:0046461)3.40353857
126daunorubicin metabolic process (GO:0044597)3.37373401
127polyketide metabolic process (GO:0030638)3.37373401
128doxorubicin metabolic process (GO:0044598)3.37373401
129serine family amino acid biosynthetic process (GO:0009070)3.34737138
130regulation of bile acid biosynthetic process (GO:0070857)3.33523516
131protein-lipid complex subunit organization (GO:0071825)3.24768999
132primary alcohol metabolic process (GO:0034308)3.24169211
133acute inflammatory response (GO:0002526)3.23591506
134hormone catabolic process (GO:0042447)3.22496365
135positive regulation of coagulation (GO:0050820)3.19564792
136arginine catabolic process (GO:0006527)3.10773183
137negative regulation of lipid transport (GO:0032369)3.09901273
138regulation of sterol transport (GO:0032371)3.07037534

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.43477209
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.32816485
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.16903925
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.95654427
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.59643259
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.62392769
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.27146041
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.62773346
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.28359028
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18094664
11CLOCK_20551151_ChIP-Seq_293T_Human2.11771189
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5119181
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.83109486
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74510504
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.69378497
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.65849600
17GATA1_22025678_ChIP-Seq_K562_Human1.61790131
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56760907
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.53326495
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.53326495
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.53326495
22FOXA2_19822575_ChIP-Seq_HepG2_Human1.49285796
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42496348
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38622169
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37598924
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33986894
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.29762982
28HTT_18923047_ChIP-ChIP_STHdh_Human1.29319417
29SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28433286
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.20034767
31HNF4A_19822575_ChIP-Seq_HepG2_Human1.19583041
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17789936
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16843415
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15795372
35TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15704285
36CTCF_27219007_Chip-Seq_Bcells_Human1.14639173
37NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13980206
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13497054
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13155366
40NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13132212
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12173656
42RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08139237
43OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07745590
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04957579
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.04821338
46SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04432843
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04329394
48RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99008242
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98181396
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98080098
51NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97550168
52SA1_27219007_Chip-Seq_Bcells_Human0.97380651
53SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96923276
54AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96846651
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96547610
56NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96547610
57SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95146299
58SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94441609
59DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94402026
60RACK7_27058665_Chip-Seq_MCF-7_Human0.92925212
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90025987
62TET1_21451524_ChIP-Seq_MESCs_Mouse0.89302616
63GATA4_25053715_ChIP-Seq_YYC3_Human0.87756895
64ESR2_21235772_ChIP-Seq_MCF-7_Human0.87664300
65BCAT_22108803_ChIP-Seq_LS180_Human0.85828809
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85748022
67SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85598640
68SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84795668
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84207742
70POU5F1_16518401_ChIP-PET_MESCs_Mouse0.81676084
71SA1_22415368_ChIP-Seq_MEFs_Mouse0.81083394
72ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80804725
73STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.80635191
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80014522
75ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79360399
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79343004
77KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78848714
78SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.78308313
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78307887
80SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77958131
81PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77697008
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77635406
83SA1_27219007_Chip-Seq_ERYTHROID_Human0.76600149
84AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76127200
85CDX2_19796622_ChIP-Seq_MESCs_Mouse0.75621294
86SMC4_20622854_ChIP-Seq_HELA_Human0.74580105
87RAD21_21589869_ChIP-Seq_MESCs_Mouse0.74357639
88SMC1_22415368_ChIP-Seq_MEFs_Mouse0.73872877
89PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73355195
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.72927900
91ESR1_21235772_ChIP-Seq_MCF-7_Human0.71274071
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70248226
93SOX2_21211035_ChIP-Seq_LN229_Human0.70112636
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.67514294
95STAT3_1855785_ChIP-Seq_MESCs_Mouse0.67460758
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.66918322
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.66471580
98* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65993743
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.64210186
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.64164479
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.63903212
102JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.63719416
103BP1_19119308_ChIP-ChIP_Hs578T_Human0.63377221
104TCF3_18692474_ChIP-Seq_MESCs_Mouse0.63255022
105FOXO3_23340844_ChIP-Seq_DLD1_Human0.61389839
106PIAS1_25552417_ChIP-Seq_VCAP_Human0.61383325
107SOX2_20726797_ChIP-Seq_SW620_Human0.61135126
108PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.60955541
109CEBPB_22108803_ChIP-Seq_LS180_Human0.60525777
110FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60010694
111ESR1_20079471_ChIP-ChIP_T-47D_Human0.59447078
112FOXA1_25552417_ChIP-Seq_VCAP_Human0.58494628
113PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.57921058
114ERG_21242973_ChIP-ChIP_JURKAT_Human0.57796502
115RARA_24833708_ChIP-Seq_LIVER_Mouse0.57501911
116BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57416011
117AR_20517297_ChIP-Seq_VCAP_Human0.57272371
118PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.55965315
119CBP_21632823_ChIP-Seq_H3396_Human0.55883803
120RARB_24833708_ChIP-Seq_LIVER_Mouse0.54654948
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.54516718
122P53_21459846_ChIP-Seq_SAOS-2_Human0.53989642
123STAT1_17558387_ChIP-Seq_HELA_Human0.53562382
124* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.52953550
125FOXH1_21741376_ChIP-Seq_EPCs_Human0.52516367
126GATA1_19941826_ChIP-Seq_K562_Human0.52283355
127CJUN_26792858_Chip-Seq_BT549_Human0.52088341
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.51193442
129TBX20_22080862_ChIP-Seq_HEART_Mouse0.51123570
130TBX20_22328084_ChIP-Seq_HEART_Mouse0.51123570
131IRF8_22096565_ChIP-ChIP_GC-B_Human0.50095980
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.49904925
133EGR1_19032775_ChIP-ChIP_M12_Human0.49438301
134TAF2_19829295_ChIP-Seq_ESCs_Human0.47568806
135GATA2_19941826_ChIP-Seq_K562_Human0.47138962
136MYC_19915707_ChIP-ChIP_AK7_Human0.47132481
137AR_21572438_ChIP-Seq_LNCaP_Human0.45936221
138ZNF263_19887448_ChIP-Seq_K562_Human0.45843546
139MYC_27129775_Chip-Seq_CORNEA_Mouse0.45841201
140PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45817076
141LXR_22292898_ChIP-Seq_THP-1_Human0.45637426
142GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.45294441
143SMAD4_21741376_ChIP-Seq_EPCs_Human0.45215659
144BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.45064172
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.44973980
146TAF15_26573619_Chip-Seq_HEK293_Human0.44711001
147SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.44652577
148CSB_26484114_Chip-Seq_FIBROBLAST_Human0.44468656
149SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.42700281

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.81310869
2MP0005360_urolithiasis7.11021155
3MP0005085_abnormal_gallbladder_physiolo5.96748447
4MP0005365_abnormal_bile_salt5.84982305
5MP0008875_abnormal_xenobiotic_pharmacok4.87885874
6MP0010329_abnormal_lipoprotein_level3.72610960
7MP0003806_abnormal_nucleotide_metabolis3.71538569
8MP0003252_abnormal_bile_duct3.64175536
9MP0009840_abnormal_foam_cell3.13895337
10MP0005332_abnormal_amino_acid2.72002163
11MP0005083_abnormal_biliary_tract2.70628324
12MP0003191_abnormal_cellular_cholesterol2.52227293
13MP0003195_calcinosis2.47072523
14MP0001666_abnormal_nutrient_absorption2.35127310
15MP0000678_abnormal_parathyroid_gland2.19931802
16MP0002118_abnormal_lipid_homeostasis2.17330497
17MP0005503_abnormal_tendon_morphology2.16433258
18MP0000609_abnormal_liver_physiology2.08943903
19MP0004019_abnormal_vitamin_homeostasis2.04634469
20MP0005319_abnormal_enzyme/_coenzyme1.78380061
21MP0005670_abnormal_white_adipose1.68987880
22MP0002138_abnormal_hepatobiliary_system1.64033667
23MP0001764_abnormal_homeostasis1.60518351
24MP0003868_abnormal_feces_composition1.57825052
25MP0003011_delayed_dark_adaptation1.56020477
26MP0002909_abnormal_adrenal_gland1.52324522
27MP0005584_abnormal_enzyme/coenzyme_acti1.50335376
28MP0009697_abnormal_copulation1.44648689
29MP0003941_abnormal_skin_development1.42547417
30MP0003186_abnormal_redox_activity1.38334464
31MP0002254_reproductive_system_inflammat1.31813883
32MP0009643_abnormal_urine_homeostasis1.27908633
33MP0003705_abnormal_hypodermis_morpholog1.26751746
34MP0000604_amyloidosis1.23993127
35MP0005647_abnormal_sex_gland1.16697500
36MP0003279_aneurysm1.16358145
37MP0004130_abnormal_muscle_cell1.16183570
38MP0002837_dystrophic_cardiac_calcinosis1.15866265
39MP0008438_abnormal_cutaneous_collagen1.14028850
40MP0005451_abnormal_body_composition1.13565330
41MP0010368_abnormal_lymphatic_system1.11546711
42MP0002876_abnormal_thyroid_physiology1.08902561
43MP0002108_abnormal_muscle_morphology1.08479323
44MP0002971_abnormal_brown_adipose1.08425987
45MP0003690_abnormal_glial_cell1.07669651
46MP0001958_emphysema1.06415998
47MP0009764_decreased_sensitivity_to1.06066107
48MP0003656_abnormal_erythrocyte_physiolo1.06028577
49MP0005257_abnormal_intraocular_pressure1.04238375
50MP0001661_extended_life_span1.04061126
51MP0000598_abnormal_liver_morphology1.03271529
52MP0005023_abnormal_wound_healing0.97950624
53MP0009763_increased_sensitivity_to0.97375886
54MP0005636_abnormal_mineral_homeostasis0.93959670
55MP0001915_intracranial_hemorrhage0.92941539
56MP0005508_abnormal_skeleton_morphology0.91661497
57MP0003879_abnormal_hair_cell0.89538500
58MP0005666_abnormal_adipose_tissue0.88610271
59MP0003566_abnormal_cell_adhesion0.88491307
60MP0000003_abnormal_adipose_tissue0.87023513
61MP0005377_hearing/vestibular/ear_phenot0.85913752
62MP0003878_abnormal_ear_physiology0.85913752
63MP0003724_increased_susceptibility_to0.85787427
64MP0005376_homeostasis/metabolism_phenot0.85486680
65MP0005334_abnormal_fat_pad0.84133008
66MP0009642_abnormal_blood_homeostasis0.83362645
67MP0000751_myopathy0.82690382
68MP0008469_abnormal_protein_level0.82327964
69MP0002078_abnormal_glucose_homeostasis0.78776977
70MP0005058_abnormal_lysosome_morphology0.77194983
71MP0003959_abnormal_lean_body0.75663385
72MP0005535_abnormal_body_temperature0.74904812
73MP0001756_abnormal_urination0.73529858
74MP0002933_joint_inflammation0.72918691
75MP0006036_abnormal_mitochondrial_physio0.69688236
76MP0001849_ear_inflammation0.68001145
77MP0005275_abnormal_skin_tensile0.67337561
78MP0005084_abnormal_gallbladder_morpholo0.67296360
79MP0009115_abnormal_fat_cell0.66998282
80MP0009765_abnormal_xenobiotic_induced0.66926403
81MP0003329_amyloid_beta_deposits0.65345010
82MP0010030_abnormal_orbit_morphology0.65298097
83MP0009384_cardiac_valve_regurgitation0.63249168
84MP0005408_hypopigmentation0.62556745
85MP0000639_abnormal_adrenal_gland0.62367553
86MP0006138_congestive_heart_failure0.61715434
87MP0005164_abnormal_response_to0.61566737
88MP0009672_abnormal_birth_weight0.60378920
89MP0005448_abnormal_energy_balance0.59873605
90MP0008004_abnormal_stomach_pH0.59468314
91MP0002896_abnormal_bone_mineralization0.59194270
92MP0005266_abnormal_metabolism0.58758631
93MP0004381_abnormal_hair_follicle0.57173001
94MP0004185_abnormal_adipocyte_glucose0.54564627
95MP0004883_abnormal_blood_vessel0.54223016
96MP0003075_altered_response_to0.53179113
97MP0000013_abnormal_adipose_tissue0.51572555
98MP0002136_abnormal_kidney_physiology0.51526327
99MP0002998_abnormal_bone_remodeling0.51467762
100MP0002168_other_aberrant_phenotype0.51093033
101MP0005220_abnormal_exocrine_pancreas0.50643874
102MP0009053_abnormal_anal_canal0.50526908
103MP0000343_altered_response_to0.50497911
104MP0000767_abnormal_smooth_muscle0.50213413
105MP0002796_impaired_skin_barrier0.50169619
106MP0000566_synostosis0.49985572
107MP0005390_skeleton_phenotype0.49655147
108MP0003638_abnormal_response/metabolism_0.49537594
109MP0005395_other_phenotype0.49377499
110MP0000249_abnormal_blood_vessel0.49167616
111MP0000230_abnormal_systemic_arterial0.45489709
112MP0008874_decreased_physiological_sensi0.45346028
113MP0002060_abnormal_skin_morphology0.45117371
114MP0002970_abnormal_white_adipose0.45084905
115MP0005595_abnormal_vascular_smooth0.44953741
116MP0005167_abnormal_blood-brain_barrier0.44226491
117MP0003953_abnormal_hormone_level0.43443110
118MP0001542_abnormal_bone_strength0.43155688
119MP0004782_abnormal_surfactant_physiolog0.43046455
120MP0002928_abnormal_bile_duct0.42725028
121MP0004272_abnormal_basement_membrane0.42220285
122MP0005375_adipose_tissue_phenotype0.41325234
123MP0001853_heart_inflammation0.40195455
124MP0005166_decreased_susceptibility_to0.39916686
125MP0002295_abnormal_pulmonary_circulatio0.39576637
126MP0002090_abnormal_vision0.38124077
127MP0001243_abnormal_dermal_layer0.37896793
128MP0001881_abnormal_mammary_gland0.36227536
129MP0001879_abnormal_lymphatic_vessel0.35780547
130MP0005464_abnormal_platelet_physiology0.35312779
131MP0002249_abnormal_larynx_morphology0.33784073
132MP0006035_abnormal_mitochondrial_morpho0.33184244

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.13190955
2Intrahepatic cholestasis (HP:0001406)6.83787763
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.73123171
4Prolonged partial thromboplastin time (HP:0003645)6.12874134
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.10413018
6Xanthomatosis (HP:0000991)6.09805206
7Hypobetalipoproteinemia (HP:0003563)5.84845329
8Hyperlipoproteinemia (HP:0010980)5.56841244
9Complement deficiency (HP:0004431)5.43385774
10Hypolipoproteinemia (HP:0010981)4.73415966
11Joint hemorrhage (HP:0005261)4.48976366
12Hypoalphalipoproteinemia (HP:0003233)4.46977619
13Hyperammonemia (HP:0001987)4.42404905
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.36200782
15Hyperglycinemia (HP:0002154)4.25195250
16Ketosis (HP:0001946)4.24878771
17Hyperglycinuria (HP:0003108)4.23453472
18Abnormality of the common coagulation pathway (HP:0010990)4.22477079
19Epidermoid cyst (HP:0200040)4.21316682
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.14559912
21Abnormality of glycine metabolism (HP:0010895)4.10443678
22Abnormality of serine family amino acid metabolism (HP:0010894)4.10443678
23Abnormality of complement system (HP:0005339)3.90046818
24Hypoglycemic coma (HP:0001325)3.85555454
25Fat malabsorption (HP:0002630)3.78628254
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.74974157
27Abnormality of methionine metabolism (HP:0010901)3.67482307
28Abnormality of aspartate family amino acid metabolism (HP:0010899)3.63976502
29Abnormality of the intrinsic pathway (HP:0010989)3.47216177
30Protrusio acetabuli (HP:0003179)3.42694492
31Hypercholesterolemia (HP:0003124)3.40325838
32Abnormality of fatty-acid metabolism (HP:0004359)3.35047851
33Conjugated hyperbilirubinemia (HP:0002908)3.33554764
34Systemic lupus erythematosus (HP:0002725)3.29685000
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.14882672
36Ketoacidosis (HP:0001993)3.13931915
37Abnormality of pyrimidine metabolism (HP:0004353)3.03141128
38Myocardial infarction (HP:0001658)3.02697225
39Hyperbilirubinemia (HP:0002904)2.97666290
40Spontaneous abortion (HP:0005268)2.89610736
41Steatorrhea (HP:0002570)2.80443500
42Delayed CNS myelination (HP:0002188)2.79947412
43Abnormality of nucleobase metabolism (HP:0010932)2.79089158
44Abnormality of serum amino acid levels (HP:0003112)2.74625706
45Hepatocellular carcinoma (HP:0001402)2.71343766
46Skin nodule (HP:0200036)2.70066744
47Abnormality of purine metabolism (HP:0004352)2.67063173
48Dicarboxylic aciduria (HP:0003215)2.66528792
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.66528792
50Metabolic acidosis (HP:0001942)2.59988153
51Amyloidosis (HP:0011034)2.55281608
52Lethargy (HP:0001254)2.51734932
53Hyperphosphatemia (HP:0002905)2.49518354
54Abnormal respiratory motile cilium physiology (HP:0012261)2.48702164
55Mitral stenosis (HP:0001718)2.46240075
56Vascular calcification (HP:0004934)2.42655255
57Hydroxyprolinuria (HP:0003080)2.42435717
58Abnormality of proline metabolism (HP:0010907)2.42435717
59Cerebral edema (HP:0002181)2.41045431
60Rickets (HP:0002748)2.39386932
61Glomerulonephritis (HP:0000099)2.39210121
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.38660737
63Abnormal ciliary motility (HP:0012262)2.35648457
64Hypoglycemic seizures (HP:0002173)2.34970565
65Vertebral compression fractures (HP:0002953)2.32102070
66Broad metatarsal (HP:0001783)2.30984567
67Spastic diplegia (HP:0001264)2.29263114
68Enlarged kidneys (HP:0000105)2.28068872
69Hypochromic microcytic anemia (HP:0004840)2.27542330
70Esophageal varix (HP:0002040)2.23635099
71Cardiovascular calcification (HP:0011915)2.23339455
72Pancreatitis (HP:0001733)2.21517140
73Neonatal onset (HP:0003623)2.20978533
74Abnormal gallbladder morphology (HP:0012437)2.19413344
75Recurrent gram-negative bacterial infections (HP:0005420)2.18140342
76Cholecystitis (HP:0001082)2.17338260
77Abnormal gallbladder physiology (HP:0012438)2.17338260
78Sensorimotor neuropathy (HP:0007141)2.16513787
79Cholelithiasis (HP:0001081)2.15611727
80Gout (HP:0001997)2.14856900
81Purpura (HP:0000979)2.14598206
82Gingival bleeding (HP:0000225)2.12571254
83Vomiting (HP:0002013)2.10862610
84Oligomenorrhea (HP:0000876)2.10668634
85Atrioventricular block (HP:0001678)2.10107345
86Lymphangioma (HP:0100764)2.09682999
87Rhinitis (HP:0012384)2.09325753
88Malnutrition (HP:0004395)2.08732727
89Generalized aminoaciduria (HP:0002909)2.08548635
90Irritability (HP:0000737)2.07017541
91Back pain (HP:0003418)2.04506826
92Reduced antithrombin III activity (HP:0001976)2.04360632
93Menorrhagia (HP:0000132)2.03359872
94Bile duct proliferation (HP:0001408)1.99171401
95Abnormal biliary tract physiology (HP:0012439)1.99171401
96Acanthocytosis (HP:0001927)1.98844132
97Hemorrhage of the eye (HP:0011885)1.97616213
98Abnormality of the Achilles tendon (HP:0005109)1.96404857
99Hypertriglyceridemia (HP:0002155)1.96009668
100Premature rupture of membranes (HP:0001788)1.95881253
101Brushfield spots (HP:0001088)1.94144388
102Abnormal cartilage morphology (HP:0002763)1.93693148
103Choanal stenosis (HP:0000452)1.93582670
104Aortic aneurysm (HP:0004942)1.93556244
105Nephritis (HP:0000123)1.92318291
106Late onset (HP:0003584)1.91981279
107Thrombophlebitis (HP:0004418)1.89712668
108Tetany (HP:0001281)1.87266568
109Biconcave vertebral bodies (HP:0004586)1.84699943
110Hyperinsulinemic hypoglycemia (HP:0000825)1.84613421
111Renal cortical cysts (HP:0000803)1.84423795
112J-shaped sella turcica (HP:0002680)1.83870277
113Wrist flexion contracture (HP:0001239)1.83011702
114Hyperphosphaturia (HP:0003109)1.81408197
115Respiratory distress (HP:0002098)1.79286618
116Hyperuricemia (HP:0002149)1.77197317
117Increased purine levels (HP:0004368)1.77197317
118Abnormality of the gallbladder (HP:0005264)1.76285562
119Opisthotonus (HP:0002179)1.76253724
120Decreased circulating renin level (HP:0003351)1.73958152
121Elevated alkaline phosphatase (HP:0003155)1.73178812
122Blue sclerae (HP:0000592)1.72995293
123Abnormal enzyme/coenzyme activity (HP:0012379)1.72562473
124Acanthosis nigricans (HP:0000956)1.70920542
125Abnormality of vitamin metabolism (HP:0100508)1.70680146
126Osteomalacia (HP:0002749)1.70380173
127Abnormality of alkaline phosphatase activity (HP:0004379)1.69350892
128Nonimmune hydrops fetalis (HP:0001790)1.67408233
129Cerebral palsy (HP:0100021)1.67161348
130Cervical subluxation (HP:0003308)1.66092335
131Ectopia lentis (HP:0001083)1.65740454
132Potter facies (HP:0002009)1.65074721
133Facial shape deformation (HP:0011334)1.65074721
134Pulmonary embolism (HP:0002204)1.64804356
135Hypophosphatemia (HP:0002148)1.64700976
136Shallow orbits (HP:0000586)1.61784008
137Abnormal delivery (HP:0001787)1.61019348
138Abnormality of carpal bone ossification (HP:0006257)1.60249719
139Alkalosis (HP:0001948)1.58581903
140Ankle contracture (HP:0006466)1.56785869
141Turricephaly (HP:0000262)1.56613045
142Polycythemia (HP:0001901)1.56418616
143Vascular tortuosity (HP:0004948)1.54692171

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.47205107
2SIK14.78797575
3ERN14.21357056
4FGFR43.78271082
5MAPK153.51096764
6DDR23.12397528
7INSRR2.58780766
8TRIB32.45010261
9MST1R2.18069119
10ERBB42.15838312
11TAOK32.07686608
12MAP2K41.69920101
13PKN21.66930120
14PIK3CG1.63774354
15DAPK21.56617370
16TIE11.54268755
17LATS11.47115245
18MAPK111.43328054
19FGFR21.43064278
20ABL21.42082862
21MYLK1.39347997
22PTK61.39213149
23SMG11.39072535
24PRKAA21.32030295
25KDR1.30954454
26PAK41.30518502
27NEK91.29949465
28TYK21.26614110
29CDC42BPA1.24455307
30FLT31.23037602
31GRK11.19790874
32AKT31.18943606
33TGFBR21.18747633
34CAMK1D1.14563772
35MAPK121.13576455
36NTRK11.12827230
37FRK1.12508161
38TESK11.11436721
39PINK11.10754734
40ARAF1.07345278
41GSK3A1.04017383
42MAPKAPK31.02200177
43JAK21.01053781
44JAK11.00914715
45MAP2K21.00910168
46MAP3K70.98928864
47PRKG20.98125406
48EPHB10.94158101
49MAPK40.91534379
50DMPK0.88121421
51PRPF4B0.86229958
52MET0.84566325
53TTK0.84465480
54PDGFRA0.84343126
55KIT0.84055824
56GRK50.83091680
57EPHB20.82887671
58EPHA30.81352459
59TNIK0.80976685
60PRKACG0.80104966
61CSK0.79940458
62EPHA20.79553854
63DAPK30.75738886
64PRKCZ0.75487866
65MAP2K10.75286977
66TBK10.74475139
67IRAK30.74255590
68MAP3K30.74154879
69TTN0.73832427
70MAPK70.73356236
71CAMK2G0.72131123
72MAP2K30.72026257
73MTOR0.68260793
74ERBB20.66510090
75PTK20.66383570
76CAMK1G0.65792466
77PDPK10.64625328
78GRK60.63749680
79STK38L0.62814089
80IGF1R0.62344175
81ILK0.62312761
82STK160.61888988
83PDGFRB0.61675643
84VRK20.61602201
85FGFR30.61165906
86PAK20.59885626
87CDK60.58272655
88CDC70.57280559
89DYRK20.55786587
90PRKAA10.55597588
91PKN10.55290154
92PRKG10.52948209
93SGK30.52324043
94IRAK10.52051393
95CSNK1G10.51885324
96MAP3K140.51873922
97RIPK10.50765674
98PRKCQ0.50347341
99ROCK10.47725767
100STK380.46925604
101BMX0.45735194
102PAK30.45626243
103AKT20.45196126
104FER0.44316293
105PDK40.44120652
106PDK30.44120652
107MUSK0.44084418
108PRKCG0.42561622
109STK240.42499004
110PDK20.42494636
111SGK4940.42241279
112SGK2230.42241279
113SRC0.41415510
114ITK0.40817001
115EEF2K0.40761669
116LMTK20.40591015
117SGK20.39544852
118PTK2B0.38020335
119PRKD10.37956324
120NLK0.37928498
121IRAK20.36914331
122ICK0.36672542
123MAPK30.35863569
124LATS20.35180243
125NME10.34090626
126FGFR10.33939345
127PRKCH0.33937179
128CDK90.33044068
129EGFR0.32637835
130LRRK20.32574932
131MAP3K60.32171763
132PRKACA0.32056296
133ADRBK10.32013788
134IKBKE0.31407502
135CAMK10.31239481
136ABL10.30879246
137RPS6KA20.30221153
138OBSCN0.30149640
139PIK3CA0.29958618
140PDK10.29782398

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.32940156
2Nitrogen metabolism_Homo sapiens_hsa009103.50018333
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15473275
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.03384336
5Arginine biosynthesis_Homo sapiens_hsa002202.87439389
6Complement and coagulation cascades_Homo sapiens_hsa046102.84867111
7Tryptophan metabolism_Homo sapiens_hsa003802.72213124
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71045190
9Fatty acid degradation_Homo sapiens_hsa000712.54643495
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.52131710
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51109199
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.41206250
13PPAR signaling pathway_Homo sapiens_hsa033202.23100893
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.21226626
15Butanoate metabolism_Homo sapiens_hsa006502.18651869
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18388307
17Propanoate metabolism_Homo sapiens_hsa006402.14255988
18Peroxisome_Homo sapiens_hsa041462.10028052
19Histidine metabolism_Homo sapiens_hsa003402.08569809
20Chemical carcinogenesis_Homo sapiens_hsa052041.98380935
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.98236043
22Fatty acid metabolism_Homo sapiens_hsa012121.91194975
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.91172300
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85877400
25Caffeine metabolism_Homo sapiens_hsa002321.82038280
26Staphylococcus aureus infection_Homo sapiens_hsa051501.81075654
27beta-Alanine metabolism_Homo sapiens_hsa004101.72410342
28Retinol metabolism_Homo sapiens_hsa008301.70906232
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62961382
30Phenylalanine metabolism_Homo sapiens_hsa003601.57387446
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.56326181
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54576533
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46306027
34Bile secretion_Homo sapiens_hsa049761.45550398
35Fatty acid elongation_Homo sapiens_hsa000621.45341436
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45188471
37Tyrosine metabolism_Homo sapiens_hsa003501.45158739
38Pyruvate metabolism_Homo sapiens_hsa006201.41162234
39Selenocompound metabolism_Homo sapiens_hsa004501.30345398
40Starch and sucrose metabolism_Homo sapiens_hsa005001.29998522
41Sulfur metabolism_Homo sapiens_hsa009201.28162547
42Fat digestion and absorption_Homo sapiens_hsa049751.25041710
43ABC transporters_Homo sapiens_hsa020101.13456317
44Carbon metabolism_Homo sapiens_hsa012001.11046716
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.09175910
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08661948
47Biosynthesis of amino acids_Homo sapiens_hsa012301.03928657
48Arginine and proline metabolism_Homo sapiens_hsa003301.02167521
49Vitamin B6 metabolism_Homo sapiens_hsa007500.99116853
50Steroid biosynthesis_Homo sapiens_hsa001000.98274069
51Folate biosynthesis_Homo sapiens_hsa007900.96198088
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90213351
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85095255
54Vitamin digestion and absorption_Homo sapiens_hsa049770.84381148
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84205620
56Glycerolipid metabolism_Homo sapiens_hsa005610.82134600
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.81499455
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.81479543
59Sulfur relay system_Homo sapiens_hsa041220.81062899
60Glutathione metabolism_Homo sapiens_hsa004800.79468897
61Fatty acid biosynthesis_Homo sapiens_hsa000610.77987067
62Lysine degradation_Homo sapiens_hsa003100.71922098
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64582889
64Pentose phosphate pathway_Homo sapiens_hsa000300.58994943
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56648354
66Metabolic pathways_Homo sapiens_hsa011000.47192200
67Prion diseases_Homo sapiens_hsa050200.45945781
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42084316
69One carbon pool by folate_Homo sapiens_hsa006700.37622965
70Linoleic acid metabolism_Homo sapiens_hsa005910.37427191
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35727062
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.35567622
73Other glycan degradation_Homo sapiens_hsa005110.34998804
74Galactose metabolism_Homo sapiens_hsa000520.31407253
75Insulin resistance_Homo sapiens_hsa049310.29035980
76Mineral absorption_Homo sapiens_hsa049780.26859902
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.21937497
78Fructose and mannose metabolism_Homo sapiens_hsa000510.21725254
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13588592
80Glucagon signaling pathway_Homo sapiens_hsa049220.10734596
81AMPK signaling pathway_Homo sapiens_hsa041520.10645504
82Ovarian steroidogenesis_Homo sapiens_hsa049130.08010911
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.03973103
84Arachidonic acid metabolism_Homo sapiens_hsa005900.03845556
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.02637726
86Systemic lupus erythematosus_Homo sapiens_hsa053220.01669427
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.01276646
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2170907
89Regulation of autophagy_Homo sapiens_hsa04140-0.2125966
90Pertussis_Homo sapiens_hsa05133-0.1935955
91ECM-receptor interaction_Homo sapiens_hsa04512-0.1755510
92Protein digestion and absorption_Homo sapiens_hsa04974-0.1721453
93Lysosome_Homo sapiens_hsa04142-0.1702137
94Renin-angiotensin system_Homo sapiens_hsa04614-0.1676369
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1535618
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1487179
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1440160
98Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1436006
99African trypanosomiasis_Homo sapiens_hsa05143-0.1387055
100TGF-beta signaling pathway_Homo sapiens_hsa04350-0.1231489
101Amoebiasis_Homo sapiens_hsa05146-0.1186458
102Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0872758
103Ether lipid metabolism_Homo sapiens_hsa00565-0.0858044
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0774872
105Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0766151
106Insulin signaling pathway_Homo sapiens_hsa04910-0.0694373
107Pancreatic secretion_Homo sapiens_hsa04972-0.0327050
108Focal adhesion_Homo sapiens_hsa04510-0.0074993
109Tight junction_Homo sapiens_hsa04530-0.0069442

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