ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	base-excision repair, AP site formation (GO:0006285)	5.98099949
2	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	5.81200678
3	sequestering of actin monomers (GO:0042989)	5.20094233
4	ribosomal small subunit assembly (GO:0000028)	5.18138756
5	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	5.13500145
6	endothelium development (GO:0003158)	4.94646890
7	protein neddylation (GO:0045116)	4.88090155
8	pyrimidine nucleotide catabolic process (GO:0006244)	4.83125309
9	thrombin receptor signaling pathway (GO:0070493)	4.74468833
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.72912714
11	deoxyribonucleotide catabolic process (GO:0009264)	4.35798435
12	seminiferous tubule development (GO:0072520)	4.14716555
13	ATP synthesis coupled proton transport (GO:0015986)	4.12684437
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.12684437
15	regulation of transmission of nerve impulse (GO:0051969)	4.12482219
16	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	4.11399911
17	deoxyribose phosphate catabolic process (GO:0046386)	4.10099776
18	aggressive behavior (GO:0002118)	3.90959052
19	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.87846668
20	viral transcription (GO:0019083)	3.78393548
21	polyketide metabolic process (GO:0030638)	3.69103521
22	doxorubicin metabolic process (GO:0044598)	3.69103521
23	daunorubicin metabolic process (GO:0044597)	3.69103521
24	protein complex biogenesis (GO:0070271)	3.68821307
25	translational termination (GO:0006415)	3.66316104
26	GPI anchor biosynthetic process (GO:0006506)	3.65588742
27	positive regulation of B cell differentiation (GO:0045579)	3.63060174
28	platelet dense granule organization (GO:0060155)	3.51640073
29	definitive hemopoiesis (GO:0060216)	3.45605819
30	mannosylation (GO:0097502)	3.45320652
31	negative regulation of B cell apoptotic process (GO:0002903)	3.44978836
32	purine deoxyribonucleotide catabolic process (GO:0009155)	3.41407173
33	mitochondrial respiratory chain complex assembly (GO:0033108)	3.35269628
34	epithelial cell differentiation involved in kidney development (GO:0035850)	3.34206865
35	aminoglycoside antibiotic metabolic process (GO:0030647)	3.32115378
36	2-deoxyribonucleotide metabolic process (GO:0009394)	3.30694552
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.23616765
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.23616765
39	NADH dehydrogenase complex assembly (GO:0010257)	3.23616765
40	GPI anchor metabolic process (GO:0006505)	3.21678339
41	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.19692751
42	galactose catabolic process (GO:0019388)	3.18698212
43	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.17928712
44	C-terminal protein lipidation (GO:0006501)	3.15229144
45	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.13917792
46	low-density lipoprotein particle remodeling (GO:0034374)	3.12626767
47	deoxyribose phosphate metabolic process (GO:0019692)	3.11605412
48	cell differentiation involved in metanephros development (GO:0072202)	3.10336847
49	translational elongation (GO:0006414)	3.10042780
50	cotranslational protein targeting to membrane (GO:0006613)	3.09621822
51	relaxation of smooth muscle (GO:0044557)	3.08263580
52	preassembly of GPI anchor in ER membrane (GO:0016254)	3.05270602
53	protein targeting to ER (GO:0045047)	3.04655858
54	protein localization to endoplasmic reticulum (GO:0070972)	2.99765402
55	purine-containing compound salvage (GO:0043101)	2.99548852
56	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.99040708
57	defense response to protozoan (GO:0042832)	2.97157703
58	activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)	2.97074448
59	L-ascorbic acid metabolic process (GO:0019852)	2.96963815
60	high-density lipoprotein particle remodeling (GO:0034375)	2.95354698
61	negative regulation of nitric oxide biosynthetic process (GO:0045019)	2.94780853
62	respiratory electron transport chain (GO:0022904)	2.94670705
63	electron transport chain (GO:0022900)	2.93479672
64	inner mitochondrial membrane organization (GO:0007007)	2.92919829
65	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.89890530
66	urinary tract smooth muscle contraction (GO:0014848)	2.88673178
67	purine nucleotide salvage (GO:0032261)	2.88060396
68	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.87153252
69	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.86991240
70	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.85319916
71	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.85319916
72	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.82710103
73	positive regulation of vasculogenesis (GO:2001214)	2.82482164
74	oxidative phosphorylation (GO:0006119)	2.82436366
75	cellular response to interferon-beta (GO:0035458)	2.81063323
76	viral life cycle (GO:0019058)	2.80293395
77	monoamine transport (GO:0015844)	2.78980510
78	angiogenesis involved in wound healing (GO:0060055)	2.77886498
79	artery smooth muscle contraction (GO:0014824)	2.77167419
80	blood vessel maturation (GO:0001955)	2.76087974
81	adult feeding behavior (GO:0008343)	2.76039396
82	cellular protein complex disassembly (GO:0043624)	2.74672491
83	response to protozoan (GO:0001562)	2.74617235
84	axoneme assembly (GO:0035082)	2.73774711
85	regulation of cholesterol esterification (GO:0010872)	2.73727830
86	response to interferon-beta (GO:0035456)	2.72055428
87	GMP metabolic process (GO:0046037)	2.71554879
88	valine metabolic process (GO:0006573)	2.71191503
89	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.70208454
90	L-phenylalanine catabolic process (GO:0006559)	2.70208454
91	regulation of dopamine metabolic process (GO:0042053)	2.66961371
92	regulation of catecholamine metabolic process (GO:0042069)	2.66961371
93	negative regulation of response to food (GO:0032096)	2.65599453
94	negative regulation of appetite (GO:0032099)	2.65599453
95	purine deoxyribonucleotide metabolic process (GO:0009151)	2.65121448
96	regulation of mast cell degranulation (GO:0043304)	2.64120565
97	reverse cholesterol transport (GO:0043691)	2.62893801
98	behavioral response to cocaine (GO:0048148)	2.61994030
99	deoxyribonucleotide metabolic process (GO:0009262)	2.61731814
100	neutrophil activation involved in immune response (GO:0002283)	2.60679193

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	6.01383553
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.15027695
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.78170455
4	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	3.51418611
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.89755292
6	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	2.79869987
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.79813245
8	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.73548815
9	SCL_19346495_ChIP-Seq_HPC-7_Human	2.70027112
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.48954731
11	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.41338455
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.38766481
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.29365858
14	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	2.19866061
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.14413573
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.12585488
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.06392279
18	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.00188766
19	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.99105963
20	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.95568870
21	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.95515218
22	EZH2_22144423_ChIP-Seq_EOC_Human	1.94671537
23	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.93753821
24	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.92421083
25	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.91299006
26	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.86272173
27	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.85186136
28	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.76111928
29	VDR_23849224_ChIP-Seq_CD4+_Human	1.72019745
30	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.70526520
31	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.70388865
32	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.68703142
33	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.66682205
34	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.65244127
35	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.62245398
36	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.61105201
37	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.54314241
38	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.54230309
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.50238702
40	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.49127600
41	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.47447255
42	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.47033945
43	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.46982328
44	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.44581577
45	BCL6_27268052_Chip-Seq_Bcells_Human	1.40820386
46	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.40732487
47	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.38831369
48	HTT_18923047_ChIP-ChIP_STHdh_Human	1.35168827
49	P300_27268052_Chip-Seq_Bcells_Human	1.33206699
50	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.29718589
51	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.29038483
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.27553223
53	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.27077570
54	GATA1_19941826_ChIP-Seq_K562_Human	1.27066615
55	SPI1_20517297_ChIP-Seq_HL60_Human	1.26940552
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.26876964
57	AR_20517297_ChIP-Seq_VCAP_Human	1.25371501
58	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.23560173
59	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.21862253
60	SPI1_23547873_ChIP-Seq_NB4_Human	1.20664047
61	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.19695310
62	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.17214950
63	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.14755852
64	E2F1_20622854_ChIP-Seq_HELA_Human	1.12325280
65	STAT1_20625510_ChIP-Seq_HELA_Human	1.12161668
66	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11366196
67	PHF8_20622854_ChIP-Seq_HELA_Human	1.08678482
68	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.07865980
69	XRN2_22483619_ChIP-Seq_HELA_Human	1.07704719
70	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.07497468
71	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.06081281
72	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.05403869
73	GATA1_22025678_ChIP-Seq_K562_Human	1.02091200
74	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02008110
75	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.01971668
76	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.01107593
77	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00441850
78	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99801491
79	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.99185264
80	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.97980545
81	TTF2_22483619_ChIP-Seq_HELA_Human	0.97268361
82	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95981072
83	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.94502606
84	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.92849005
85	GABP_19822575_ChIP-Seq_HepG2_Human	0.91486487
86	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.90187892
87	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.88925265
88	NANOG_19829295_ChIP-Seq_ESCs_Human	0.88639802
89	SOX2_19829295_ChIP-Seq_ESCs_Human	0.88639802
90	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.88503931
91	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.86987494
92	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.86987494
93	ERG_20517297_ChIP-Seq_VCAP_Human	0.86583284
94	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.86490733
95	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.86369747
96	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.86363893
97	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.86005390
98	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.85183177
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.83701151
100	ELK1_19687146_ChIP-ChIP_HELA_Human	0.83212431

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005464_abnormal_platelet_physiology	3.99524958
2	MP0001545_abnormal_hematopoietic_system	3.71608261
3	MP0005397_hematopoietic_system_phenotyp	3.71608261
4	MP0000465_gastrointestinal_hemorrhage	3.39179912
5	MP0009697_abnormal_copulation	3.03543066
6	MP0005646_abnormal_pituitary_gland	2.95578152
7	MP0009278_abnormal_bone_marrow	2.91623805
8	MP0009379_abnormal_foot_pigmentation	2.49379525
9	MP0001968_abnormal_touch/_nociception	2.43990929
10	MP0005084_abnormal_gallbladder_morpholo	2.41376642
11	MP0008872_abnormal_physiological_respon	2.38189935
12	MP0002653_abnormal_ependyma_morphology	2.34274207
13	MP0003880_abnormal_central_pattern	2.24653297
14	MP0005645_abnormal_hypothalamus_physiol	2.16352510
15	MP0006292_abnormal_olfactory_placode	2.10400251
16	MP0002102_abnormal_ear_morphology	2.09635045
17	MP0002148_abnormal_hypersensitivity_rea	2.01155066
18	MP0002822_catalepsy	1.98315952
19	MP0006276_abnormal_autonomic_nervous	1.92159226
20	MP0008058_abnormal_DNA_repair	1.87046524
21	MP0006036_abnormal_mitochondrial_physio	1.83425990
22	MP0000566_synostosis	1.77792665
23	MP0001986_abnormal_taste_sensitivity	1.68370039
24	MP0002132_abnormal_respiratory_system	1.66135656
25	MP0003186_abnormal_redox_activity	1.61102464
26	MP0008004_abnormal_stomach_pH	1.59997675
27	MP0002736_abnormal_nociception_after	1.59050408
28	MP0005410_abnormal_fertilization	1.58250461
29	MP0003315_abnormal_perineum_morphology	1.57149206
30	MP0001835_abnormal_antigen_presentation	1.54688136
31	MP0009765_abnormal_xenobiotic_induced	1.48126078
32	MP0003191_abnormal_cellular_cholesterol	1.46677952
33	MP0003638_abnormal_response/metabolism_	1.39698233
34	MP0001879_abnormal_lymphatic_vessel	1.38016276
35	MP0002638_abnormal_pupillary_reflex	1.37341255
36	MP0005394_taste/olfaction_phenotype	1.35980145
37	MP0005499_abnormal_olfactory_system	1.35980145
38	MP0008789_abnormal_olfactory_epithelium	1.34813497
39	MP0003724_increased_susceptibility_to	1.34354656
40	MP0003806_abnormal_nucleotide_metabolis	1.33703336
41	MP0000372_irregular_coat_pigmentation	1.30199253
42	MP0001905_abnormal_dopamine_level	1.29659272
43	MP0006072_abnormal_retinal_apoptosis	1.27515707
44	MP0002733_abnormal_thermal_nociception	1.20306104
45	MP0010030_abnormal_orbit_morphology	1.19425655
46	MP0000230_abnormal_systemic_arterial	1.18705726
47	MP0010386_abnormal_urinary_bladder	1.17335964
48	MP0001764_abnormal_homeostasis	1.13535063
49	MP0005165_increased_susceptibility_to	1.13173579
50	MP0001529_abnormal_vocalization	1.12933833
51	MP0005075_abnormal_melanosome_morpholog	1.11844335
52	MP0003718_maternal_effect	1.07915821
53	MP0000383_abnormal_hair_follicle	1.06006040
54	MP0003122_maternal_imprinting	1.03271414
55	MP0009333_abnormal_splenocyte_physiolog	1.01363679
56	MP0008873_increased_physiological_sensi	0.98576594
57	MP0002735_abnormal_chemical_nociception	0.98156917
58	MP0002282_abnormal_trachea_morphology	0.97646605
59	MP0005670_abnormal_white_adipose	0.97290421
60	MP0004885_abnormal_endolymph	0.97117303
61	MP0005551_abnormal_eye_electrophysiolog	0.96203179
62	MP0005535_abnormal_body_temperature	0.93315018
63	MP0004808_abnormal_hematopoietic_stem	0.90320995
64	MP0005167_abnormal_blood-brain_barrier	0.89418821
65	MP0009763_increased_sensitivity_to	0.89216340
66	MP0009840_abnormal_foam_cell	0.85533133
67	MP0008569_lethality_at_weaning	0.85530355
68	MP0008874_decreased_physiological_sensi	0.85485056
69	MP0010368_abnormal_lymphatic_system	0.84234018
70	MP0001756_abnormal_urination	0.84057563
71	MP0002019_abnormal_tumor_incidence	0.83735588
72	MP0004142_abnormal_muscle_tone	0.83004678
73	MP0004147_increased_porphyrin_level	0.82070284
74	MP0009643_abnormal_urine_homeostasis	0.81604996
75	MP0009046_muscle_twitch	0.79744107
76	MP0005000_abnormal_immune_tolerance	0.78858581
77	MP0008995_early_reproductive_senescence	0.78041394
78	MP0004133_heterotaxia	0.77816168
79	MP0005174_abnormal_tail_pigmentation	0.77796576
80	MP0002160_abnormal_reproductive_system	0.77661462
81	MP0008775_abnormal_heart_ventricle	0.76443153
82	MP0000631_abnormal_neuroendocrine_gland	0.75912118
83	MP0002938_white_spotting	0.74034132
84	MP0000516_abnormal_urinary_system	0.73164207
85	MP0005367_renal/urinary_system_phenotyp	0.73164207
86	MP0001970_abnormal_pain_threshold	0.72815804
87	MP0002557_abnormal_social/conspecific_i	0.72301749
88	MP0006035_abnormal_mitochondrial_morpho	0.70812206
89	MP0002067_abnormal_sensory_capabilities	0.68558746
90	MP0002272_abnormal_nervous_system	0.68003444
91	MP0009764_decreased_sensitivity_to	0.67684997
92	MP0005025_abnormal_response_to	0.67058018
93	MP0005085_abnormal_gallbladder_physiolo	0.65653487
94	MP0002398_abnormal_bone_marrow	0.65333770
95	MP0003075_altered_response_to	0.63352600
96	MP0001664_abnormal_digestion	0.61654724
97	MP0005220_abnormal_exocrine_pancreas	0.61236284
98	MP0002069_abnormal_eating/drinking_beha	0.60940455
99	MP0002572_abnormal_emotion/affect_behav	0.60669799
100	MP0000343_altered_response_to	0.60358286

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.98695325
2	Hepatocellular necrosis (HP:0001404)	4.62060033
3	Renal Fanconi syndrome (HP:0001994)	4.48818104
4	Hepatic necrosis (HP:0002605)	4.06946377
5	Increased intramyocellular lipid droplets (HP:0012240)	3.90783472
6	Petechiae (HP:0000967)	3.77523163
7	Increased hepatocellular lipid droplets (HP:0006565)	3.70577145
8	Mitochondrial inheritance (HP:0001427)	3.63545704
9	Abnormal pupillary function (HP:0007686)	3.49532999
10	Lipid accumulation in hepatocytes (HP:0006561)	3.44216515
11	Abnormality of lateral ventricle (HP:0030047)	3.40957721
12	Increased muscle lipid content (HP:0009058)	3.39524587
13	Prolonged bleeding time (HP:0003010)	3.34747637
14	Abnormal number of erythroid precursors (HP:0012131)	3.29430591
15	Reduced antithrombin III activity (HP:0001976)	3.18708459
16	3-Methylglutaconic aciduria (HP:0003535)	3.15334672
17	Thrombocytosis (HP:0001894)	3.09107766
18	Myokymia (HP:0002411)	3.08311125
19	Emotional lability (HP:0000712)	3.07901897
20	Type I transferrin isoform profile (HP:0003642)	3.06525567
21	Exertional dyspnea (HP:0002875)	3.04384440
22	Increased CSF lactate (HP:0002490)	2.99443287
23	Dicarboxylic aciduria (HP:0003215)	2.95300487
24	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.95300487
25	Abnormality of cells of the erythroid lineage (HP:0012130)	2.90990385
26	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.89628829
27	Opisthotonus (HP:0002179)	2.86997689
28	Epistaxis (HP:0000421)	2.86624737
29	Pancreatic fibrosis (HP:0100732)	2.77063964
30	Abnormal mitochondria in muscle tissue (HP:0008316)	2.75976252
31	Abnormality of renal resorption (HP:0011038)	2.71917412
32	Elevated erythrocyte sedimentation rate (HP:0003565)	2.70878729
33	Abnormal protein glycosylation (HP:0012346)	2.69768030
34	Abnormal glycosylation (HP:0012345)	2.69768030
35	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.69768030
36	Abnormal protein N-linked glycosylation (HP:0012347)	2.69768030
37	Dyschromatopsia (HP:0007641)	2.60741018
38	Macrocytic anemia (HP:0001972)	2.59148136
39	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.58717729
40	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.58717729
41	Stenosis of the external auditory canal (HP:0000402)	2.58605268
42	Agammaglobulinemia (HP:0004432)	2.54758310
43	Hepatosplenomegaly (HP:0001433)	2.53796182
44	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.53005811
45	Pancreatic cysts (HP:0001737)	2.52275418
46	Decreased central vision (HP:0007663)	2.52182370
47	True hermaphroditism (HP:0010459)	2.46038992
48	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.44855977
49	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.43594408
50	Abnormality of midbrain morphology (HP:0002418)	2.41936297
51	Molar tooth sign on MRI (HP:0002419)	2.41936297
52	Microvesicular hepatic steatosis (HP:0001414)	2.39132840
53	Nephronophthisis (HP:0000090)	2.34179668
54	Optic disc pallor (HP:0000543)	2.33508037
55	Severe visual impairment (HP:0001141)	2.33227527
56	Rimmed vacuoles (HP:0003805)	2.31523117
57	Absent thumb (HP:0009777)	2.27713059
58	Central scotoma (HP:0000603)	2.27264562
59	Acute necrotizing encephalopathy (HP:0006965)	2.26849791
60	Abnormality of the prostate (HP:0008775)	2.26398570
61	Gingival bleeding (HP:0000225)	2.25864752
62	Stomatitis (HP:0010280)	2.20127273
63	Rhabdomyolysis (HP:0003201)	2.18777173
64	Exercise intolerance (HP:0003546)	2.17242605
65	Hyperlipoproteinemia (HP:0010980)	2.16387544
66	Hypothermia (HP:0002045)	2.15433830
67	Spontaneous abortion (HP:0005268)	2.14337409
68	Tubulointerstitial nephritis (HP:0001970)	2.14103152
69	Cystic liver disease (HP:0006706)	2.13886899
70	Hyperphosphaturia (HP:0003109)	2.10194561
71	Abnormality of DNA repair (HP:0003254)	2.09266543
72	Menorrhagia (HP:0000132)	2.08283819
73	Bile duct proliferation (HP:0001408)	2.01328524
74	Abnormal biliary tract physiology (HP:0012439)	2.01328524
75	Acute encephalopathy (HP:0006846)	1.99667947
76	Abnormality of pyrimidine metabolism (HP:0004353)	1.97197670
77	Colon cancer (HP:0003003)	1.95414600
78	Fatigue (HP:0012378)	1.94630012
79	Occipital encephalocele (HP:0002085)	1.91719783
80	Increased serum lactate (HP:0002151)	1.89993442
81	Paralysis (HP:0003470)	1.89942701
82	Flattened epiphyses (HP:0003071)	1.88107449
83	Cerebellar dysplasia (HP:0007033)	1.82620410
84	Abnormality of reticulocytes (HP:0004312)	1.82315719
85	Progressive macrocephaly (HP:0004481)	1.80901318
86	Focal motor seizures (HP:0011153)	1.78795817
87	Lactic acidosis (HP:0003128)	1.77853456
88	Abnormality of macular pigmentation (HP:0008002)	1.73710748
89	Generalized aminoaciduria (HP:0002909)	1.73510700
90	Triphalangeal thumb (HP:0001199)	1.72246884
91	Fasciculations (HP:0002380)	1.71855749
92	Pallor (HP:0000980)	1.71682312
93	Sclerocornea (HP:0000647)	1.71499791
94	Gliosis (HP:0002171)	1.71286693
95	Abolished electroretinogram (ERG) (HP:0000550)	1.69446408
96	CNS demyelination (HP:0007305)	1.69377869
97	Abnormality of the renal medulla (HP:0100957)	1.68095083
98	Short nail (HP:0001799)	1.67869647
99	Pulmonary fibrosis (HP:0002206)	1.67292825
100	Granulocytopenia (HP:0001913)	1.67202263

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	5.11684624
2	BCKDK	4.43122507
3	MAP3K12	3.65381242
4	VRK2	3.59721308
5	TAOK3	3.37911538
6	MAP2K3	3.32466966
7	MAP3K11	2.51965253
8	ERN1	2.45374279
9	PBK	2.08821787
10	MAP2K4	2.00207654
11	NUAK1	1.93512981
12	KIT	1.90633426
13	CCNB1	1.84661889
14	MAP3K13	1.77455946
15	MAP4K1	1.57327130
16	MAP2K6	1.53923258
17	STK16	1.50600158
18	KDR	1.46043940
19	MAPK13	1.44630235
20	GRK6	1.42387593
21	FES	1.42177177
22	NME2	1.38469127
23	ARAF	1.37665602
24	EPHA3	1.36639910
25	MYLK	1.22937697
26	MAP3K6	1.19352748
27	TESK2	1.17581921
28	MATK	1.17275328
29	PIM2	1.15813136
30	BMX	1.09802437
31	GRK5	1.08190223
32	CSF1R	1.08130330
33	MST4	1.08065575
34	FLT3	1.07521886
35	CDK8	1.06631882
36	VRK1	1.06332759
37	DAPK1	1.05413862
38	TEC	1.05205835
39	SYK	1.03702333
40	SRPK1	1.00578964
41	MAP3K5	0.97115830
42	BTK	0.96712111
43	LRRK2	0.95480154
44	TRIM28	0.91506550
45	PIK3CG	0.89677409
46	BMPR1B	0.89174377
47	ZAK	0.88940974
48	TAF1	0.88870324
49	SCYL2	0.87493256
50	DYRK2	0.87380644
51	TIE1	0.83058507
52	TBK1	0.77152008
53	TLK1	0.76200745
54	CDK19	0.75452483
55	DYRK1B	0.75139582
56	PRKCQ	0.75049025
57	IKBKB	0.74302168
58	ATR	0.74256629
59	GRK7	0.72575600
60	TESK1	0.71481532
61	CSNK1G3	0.69961018
62	ADRBK1	0.69030486
63	ADRBK2	0.66573591
64	INSRR	0.64277073
65	DAPK3	0.62650186
66	RPS6KA5	0.56876573
67	TNK2	0.56384222
68	CSNK1G1	0.52936388
69	ITK	0.52322307
70	PKN1	0.52105177
71	DAPK2	0.50801785
72	JAK3	0.46909860
73	LMTK2	0.45999754
74	BMPR2	0.45266914
75	FER	0.44622691
76	WNK3	0.44547295
77	AURKA	0.41645225
78	PINK1	0.41618285
79	CAMK1	0.41370085
80	PASK	0.41023586
81	LCK	0.40250182
82	PDK2	0.40001508
83	TGFBR1	0.38879673
84	PRKCA	0.38693999
85	MAP3K1	0.38683095
86	LIMK1	0.37798555
87	MOS	0.36916903
88	LYN	0.34316584
89	TXK	0.33937593
90	ILK	0.33526924
91	MKNK1	0.31308652
92	CSNK1G2	0.30881177
93	MAP2K7	0.30039130
94	MAP3K7	0.29720016
95	MAPK12	0.29489306
96	CAMK2G	0.28233246
97	IGF1R	0.27881763
98	AKT2	0.26781097
99	CSNK1A1L	0.26765721
100	GRK1	0.25912512

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.94611438
2	Ribosome_Homo sapiens_hsa03010	3.79005061
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.60074129
4	Parkinsons disease_Homo sapiens_hsa05012	3.28283721
5	Base excision repair_Homo sapiens_hsa03410	2.83732869
6	RNA polymerase_Homo sapiens_hsa03020	2.04206310
7	Alzheimers disease_Homo sapiens_hsa05010	2.02185090
8	Huntingtons disease_Homo sapiens_hsa05016	1.93401482
9	Proteasome_Homo sapiens_hsa03050	1.90823591
10	Asthma_Homo sapiens_hsa05310	1.81716522
11	Peroxisome_Homo sapiens_hsa04146	1.79592624
12	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.76748047
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.69009844
14	Butanoate metabolism_Homo sapiens_hsa00650	1.61945481
15	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.60696753
16	Allograft rejection_Homo sapiens_hsa05330	1.59517880
17	Phototransduction_Homo sapiens_hsa04744	1.57832101
18	Folate biosynthesis_Homo sapiens_hsa00790	1.55482933
19	Platelet activation_Homo sapiens_hsa04611	1.55205033
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.49664862
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.49264403
22	Glutathione metabolism_Homo sapiens_hsa00480	1.49015992
23	Fatty acid elongation_Homo sapiens_hsa00062	1.48768891
24	Pentose phosphate pathway_Homo sapiens_hsa00030	1.46116587
25	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.44301422
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.42986898
27	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.41356972
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.41319723
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.37089579
30	Purine metabolism_Homo sapiens_hsa00230	1.36697725
31	Type I diabetes mellitus_Homo sapiens_hsa04940	1.35145724
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.29346223
33	Primary immunodeficiency_Homo sapiens_hsa05340	1.24502818
34	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.22524652
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.16183590
36	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.12856231
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.10146558
38	Cardiac muscle contraction_Homo sapiens_hsa04260	1.06498757
39	Protein export_Homo sapiens_hsa03060	1.04466312
40	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.02079463
41	Fatty acid degradation_Homo sapiens_hsa00071	1.00165161
42	Fatty acid metabolism_Homo sapiens_hsa01212	0.99957513
43	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.98974396
44	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.97786447
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.97425023
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.95985115
47	Olfactory transduction_Homo sapiens_hsa04740	0.94176777
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93244584
49	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.90330376
50	Rheumatoid arthritis_Homo sapiens_hsa05323	0.89933673
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.86527793
52	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.86173073
53	Graft-versus-host disease_Homo sapiens_hsa05332	0.85190099
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.84714832
55	Mismatch repair_Homo sapiens_hsa03430	0.83954365
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83713227
57	Metabolic pathways_Homo sapiens_hsa01100	0.83577668
58	Propanoate metabolism_Homo sapiens_hsa00640	0.80767356
59	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.80519188
60	Regulation of autophagy_Homo sapiens_hsa04140	0.77905884
61	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.76857934
62	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.75080616
63	DNA replication_Homo sapiens_hsa03030	0.73890090
64	Homologous recombination_Homo sapiens_hsa03440	0.73184045
65	Calcium signaling pathway_Homo sapiens_hsa04020	0.70340619
66	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.70172260
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.69901783
68	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.68826277
69	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.68546226
70	Taste transduction_Homo sapiens_hsa04742	0.66386128
71	Linoleic acid metabolism_Homo sapiens_hsa00591	0.65142607
72	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.62976398
73	Serotonergic synapse_Homo sapiens_hsa04726	0.60770501
74	Fanconi anemia pathway_Homo sapiens_hsa03460	0.60579037
75	Carbon metabolism_Homo sapiens_hsa01200	0.59984479
76	Sulfur relay system_Homo sapiens_hsa04122	0.59340510
77	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.58959018
78	Sulfur metabolism_Homo sapiens_hsa00920	0.56594668
79	Circadian entrainment_Homo sapiens_hsa04713	0.53224703
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51519716
81	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.49064131
82	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.47512052
83	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.47441247
84	One carbon pool by folate_Homo sapiens_hsa00670	0.46664497
85	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.46198458
86	RNA degradation_Homo sapiens_hsa03018	0.43923305
87	Nicotine addiction_Homo sapiens_hsa05033	0.43696021
88	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.43691282
89	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.43612918
90	Pertussis_Homo sapiens_hsa05133	0.42123306
91	Salivary secretion_Homo sapiens_hsa04970	0.41669787
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.39470852
93	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.38228124
94	Tyrosine metabolism_Homo sapiens_hsa00350	0.37138193
95	Cocaine addiction_Homo sapiens_hsa05030	0.36430150
96	Galactose metabolism_Homo sapiens_hsa00052	0.36276821
97	Renin secretion_Homo sapiens_hsa04924	0.34223220
98	African trypanosomiasis_Homo sapiens_hsa05143	0.31564524
99	Lysosome_Homo sapiens_hsa04142	0.30302959
100	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.30253136

RARRES2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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