ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	6.30617274
2	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	5.96040703
3	pyrimidine nucleotide catabolic process (GO:0006244)	5.33518088
4	negative regulation of B cell apoptotic process (GO:0002903)	5.24945862
5	positive regulation of B cell differentiation (GO:0045579)	4.79680585
6	deoxyribonucleotide catabolic process (GO:0009264)	4.75602737
7	fucose catabolic process (GO:0019317)	4.72115265
8	L-fucose metabolic process (GO:0042354)	4.72115265
9	L-fucose catabolic process (GO:0042355)	4.72115265
10	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	4.71309037
11	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	4.67009602
12	cellular response to exogenous dsRNA (GO:0071360)	4.65115483
13	deoxyribose phosphate catabolic process (GO:0046386)	4.41871582
14	centriole replication (GO:0007099)	4.39960180
15	protein complex biogenesis (GO:0070271)	4.33113311
16	purine nucleotide salvage (GO:0032261)	4.31666250
17	mast cell activation involved in immune response (GO:0002279)	4.30983661
18	mast cell degranulation (GO:0043303)	4.30983661
19	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	4.25109406
20	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	4.25109406
21	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.23589037
22	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.23589037
23	rRNA catabolic process (GO:0016075)	4.22655233
24	cellular response to interferon-beta (GO:0035458)	4.19136176
25	positive regulation of viral genome replication (GO:0045070)	4.17582580
26	short-chain fatty acid metabolic process (GO:0046459)	4.13388719
27	dosage compensation (GO:0007549)	4.05380594
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.05309864
29	NADH dehydrogenase complex assembly (GO:0010257)	4.05309864
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.05309864
31	nucleotide salvage (GO:0043173)	4.05225907
32	mitochondrial respiratory chain complex assembly (GO:0033108)	4.01741355
33	centriole assembly (GO:0098534)	4.00188784
34	purine deoxyribonucleotide catabolic process (GO:0009155)	3.90683657
35	UV protection (GO:0009650)	3.88617468
36	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.86560255
37	positive regulation of prostaglandin secretion (GO:0032308)	3.82150914
38	natural killer cell activation involved in immune response (GO:0002323)	3.80574160
39	2-deoxyribonucleotide metabolic process (GO:0009394)	3.80507848
40	cellular response to dsRNA (GO:0071359)	3.78138836
41	arginine catabolic process (GO:0006527)	3.77492139
42	phosphatidylglycerol biosynthetic process (GO:0006655)	3.74470290
43	regulation of B cell apoptotic process (GO:0002902)	3.72546009
44	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.68041060
45	Peyers patch development (GO:0048541)	3.62688712
46	mucosal-associated lymphoid tissue development (GO:0048537)	3.62688712
47	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	3.61551384
48	regulation of translation in response to stress (GO:0043555)	3.51483753
49	deoxyribose phosphate metabolic process (GO:0019692)	3.50619244
50	cardiolipin metabolic process (GO:0032048)	3.49449938
51	definitive hemopoiesis (GO:0060216)	3.48586482
52	negative regulation of cell cycle arrest (GO:0071157)	3.41877786
53	aggressive behavior (GO:0002118)	3.40734245
54	preassembly of GPI anchor in ER membrane (GO:0016254)	3.38926521
55	base-excision repair, AP site formation (GO:0006285)	3.30157161
56	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.27244861
57	regulation of mitochondrial translation (GO:0070129)	3.26707032
58	regulation of penile erection (GO:0060405)	3.24573527
59	deoxyribonucleotide metabolic process (GO:0009262)	3.24147601
60	endothelium development (GO:0003158)	3.19123097
61	regulation of MHC class I biosynthetic process (GO:0045343)	3.18231093
62	heme biosynthetic process (GO:0006783)	3.15412340
63	seminiferous tubule development (GO:0072520)	3.14704231
64	pseudouridine synthesis (GO:0001522)	3.13684869
65	regulation of icosanoid secretion (GO:0032303)	3.13110419
66	regulation of B cell differentiation (GO:0045577)	3.11533209
67	translesion synthesis (GO:0019985)	3.08091557
68	doxorubicin metabolic process (GO:0044598)	3.07101024
69	daunorubicin metabolic process (GO:0044597)	3.07101024
70	polyketide metabolic process (GO:0030638)	3.07101024
71	regulation of prostaglandin secretion (GO:0032306)	3.06762681
72	purine deoxyribonucleotide metabolic process (GO:0009151)	3.06731883
73	ribosomal small subunit assembly (GO:0000028)	3.06524208
74	response to interferon-beta (GO:0035456)	3.03035630
75	lysosome localization (GO:0032418)	3.02345075
76	tRNA methylation (GO:0030488)	3.01263152
77	histamine secretion (GO:0001821)	3.01085863
78	mature B cell differentiation involved in immune response (GO:0002313)	3.00815058
79	positive regulation of icosanoid secretion (GO:0032305)	2.99915054
80	cytochrome complex assembly (GO:0017004)	2.99711727
81	pentose-phosphate shunt (GO:0006098)	2.96952869
82	actin nucleation (GO:0045010)	2.96741744
83	valine metabolic process (GO:0006573)	2.85911826
84	positive regulation of fatty acid transport (GO:2000193)	2.82132455
85	mast cell activation (GO:0045576)	2.82124422
86	hexose catabolic process (GO:0019320)	2.82112459
87	DNA deamination (GO:0045006)	2.81074879
88	pentose metabolic process (GO:0019321)	2.77032061
89	peptidyl-arginine omega-N-methylation (GO:0035247)	2.75943053
90	purine-containing compound salvage (GO:0043101)	2.74155346
91	aminoglycoside antibiotic metabolic process (GO:0030647)	2.73760317
92	negative regulation of multicellular organism growth (GO:0040015)	2.73233600
93	regulation of translational fidelity (GO:0006450)	2.72327003
94	leukocyte tethering or rolling (GO:0050901)	2.70950558
95	T cell migration (GO:0072678)	2.69324287
96	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.68512770
97	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.67836163
98	deoxyribose phosphate biosynthetic process (GO:0046385)	2.67836163
99	tRNA processing (GO:0008033)	2.66319669
100	rRNA transcription (GO:0009303)	2.63508974

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.64396472
2	E2F7_22180533_ChIP-Seq_HELA_Human	4.25345921
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.40886541
4	SCL_19346495_ChIP-Seq_HPC-7_Human	3.32803748
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.30369448
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.18719792
7	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.15816075
8	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.83236415
9	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.79647680
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.75895787
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.58802204
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.43519457
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.40541128
14	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.37564521
15	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	2.32066954
16	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.21902466
17	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	2.20908298
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.12354065
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.06347983
20	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.05190920
21	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.00372380
22	CIITA_25753668_ChIP-Seq_RAJI_Human	1.98660000
23	ZNF263_19887448_ChIP-Seq_K562_Human	1.96122731
24	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.95006328
25	GATA1_22025678_ChIP-Seq_K562_Human	1.94194126
26	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.94018092
27	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.93587681
28	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.91171556
29	VDR_21846776_ChIP-Seq_THP-1_Human	1.88491006
30	VDR_23849224_ChIP-Seq_CD4+_Human	1.83310622
31	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.81622554
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.79956061
33	SPI1_23547873_ChIP-Seq_NB4_Human	1.73251578
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.72156005
35	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.69202805
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.68822922
37	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.67143506
38	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.65337512
39	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.65034765
40	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.63006371
41	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.61363968
42	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.58415159
43	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.57823126
44	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.56753215
45	XRN2_22483619_ChIP-Seq_HELA_Human	1.54447935
46	BCL6_27268052_Chip-Seq_Bcells_Human	1.53479186
47	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.53351701
48	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.46543159
49	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.43757166
50	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.43405656
51	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.42787664
52	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.41978983
53	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.40945343
54	KDM5A_27292631_Chip-Seq_BREAST_Human	1.40589769
55	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.39584096
56	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.39347985
57	TTF2_22483619_ChIP-Seq_HELA_Human	1.38382204
58	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.36749841
59	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.35790260
60	UTX_26944678_Chip-Seq_JUKART_Human	1.34454757
61	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.33631378
62	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.30049274
63	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.28323319
64	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.27756553
65	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.24480860
66	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.23868187
67	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.20166063
68	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.19575071
69	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.15666036
70	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.15453282
71	P300_27268052_Chip-Seq_Bcells_Human	1.15217082
72	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.14178221
73	VDR_24763502_ChIP-Seq_THP-1_Human	1.14164749
74	GATA1_19941826_ChIP-Seq_K562_Human	1.12054422
75	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.11677881
76	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.11248570
77	STAT1_20625510_ChIP-Seq_HELA_Human	1.10396102
78	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.09543058
79	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.09121738
80	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.08526366
81	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.08463260
82	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.07729049
83	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.05315440
84	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.04836149
85	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.02068487
86	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.01806184
87	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.00752110
88	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.00247069
89	TP53_22573176_ChIP-Seq_HFKS_Human	0.99447414
90	RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99070446
91	MYB_26560356_Chip-Seq_TH2_Human	0.96991982
92	P68_20966046_ChIP-Seq_HELA_Human	0.96326464
93	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.94951803
94	MYC_18940864_ChIP-ChIP_HL60_Human	0.94443871
95	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.93355978
96	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.93222230
97	PHF8_20622854_ChIP-Seq_HELA_Human	0.92586031
98	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.92446038
99	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.92445785
100	ZNF274_21170338_ChIP-Seq_K562_Hela	0.91934340

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	5.41177709
2	MP0002396_abnormal_hematopoietic_system	4.93234158
3	MP0001545_abnormal_hematopoietic_system	4.01691580
4	MP0005397_hematopoietic_system_phenotyp	4.01691580
5	MP0009697_abnormal_copulation	3.61834756
6	MP0009278_abnormal_bone_marrow	3.37812682
7	MP0000465_gastrointestinal_hemorrhage	3.31860950
8	MP0004147_increased_porphyrin_level	3.09675268
9	MP0008058_abnormal_DNA_repair	2.92063717
10	MP0001835_abnormal_antigen_presentation	2.64023044
11	MP0003656_abnormal_erythrocyte_physiolo	2.61952073
12	MP0009379_abnormal_foot_pigmentation	2.58725751
13	MP0002132_abnormal_respiratory_system	2.23478328
14	MP0003186_abnormal_redox_activity	1.90080037
15	MP0005464_abnormal_platelet_physiology	1.81818014
16	MP0006036_abnormal_mitochondrial_physio	1.74241232
17	MP0005645_abnormal_hypothalamus_physiol	1.73290696
18	MP0008789_abnormal_olfactory_epithelium	1.62725996
19	MP0005646_abnormal_pituitary_gland	1.61127753
20	MP0002148_abnormal_hypersensitivity_rea	1.58328293
21	MP0003718_maternal_effect	1.53673414
22	MP0002419_abnormal_innate_immunity	1.52033682
23	MP0003252_abnormal_bile_duct	1.45582680
24	MP0010094_abnormal_chromosome_stability	1.44548290
25	MP0003786_premature_aging	1.42864346
26	MP0006292_abnormal_olfactory_placode	1.40031760
27	MP0002876_abnormal_thyroid_physiology	1.38113689
28	MP0002398_abnormal_bone_marrow	1.37240688
29	MP0005084_abnormal_gallbladder_morpholo	1.31500608
30	MP0003880_abnormal_central_pattern	1.31039352
31	MP0002420_abnormal_adaptive_immunity	1.29255014
32	MP0001819_abnormal_immune_cell	1.27683505
33	MP0005075_abnormal_melanosome_morpholog	1.26864146
34	MP0005025_abnormal_response_to	1.25836304
35	MP0004043_abnormal_pH_regulation	1.21122423
36	MP0005394_taste/olfaction_phenotype	1.20734988
37	MP0005499_abnormal_olfactory_system	1.20734988
38	MP0006276_abnormal_autonomic_nervous	1.18622368
39	MP0001853_heart_inflammation	1.18445923
40	MP0002722_abnormal_immune_system	1.17210510
41	MP0005165_increased_susceptibility_to	1.16273263
42	MP0005174_abnormal_tail_pigmentation	1.15732896
43	MP0000689_abnormal_spleen_morphology	1.15574189
44	MP0002019_abnormal_tumor_incidence	1.15406238
45	MP0002452_abnormal_antigen_presenting	1.15182889
46	MP0009764_decreased_sensitivity_to	1.13111416
47	MP0001764_abnormal_homeostasis	1.12696504
48	MP0000681_abnormal_thyroid_gland	1.12647883
49	MP0005000_abnormal_immune_tolerance	1.10963282
50	MP0006035_abnormal_mitochondrial_morpho	1.10572255
51	MP0000716_abnormal_immune_system	1.09592453
52	MP0002234_abnormal_pharynx_morphology	1.09119223
53	MP0002723_abnormal_immune_serum	1.07183312
54	MP0002429_abnormal_blood_cell	1.06445392
55	MP0009765_abnormal_xenobiotic_induced	1.06292754
56	MP0003693_abnormal_embryo_hatching	1.04426875
57	MP0002735_abnormal_chemical_nociception	1.02617141
58	MP0003806_abnormal_nucleotide_metabolis	1.02584364
59	MP0001529_abnormal_vocalization	1.01791327
60	MP0001188_hyperpigmentation	1.00493715
61	MP0006072_abnormal_retinal_apoptosis	0.99060008
62	MP0003763_abnormal_thymus_physiology	0.98776776
63	MP0008932_abnormal_embryonic_tissue	0.98670077
64	MP0001663_abnormal_digestive_system	0.97399143
65	MP0003303_peritoneal_inflammation	0.97346901
66	MP0005330_cardiomyopathy	0.96004511
67	MP0002405_respiratory_system_inflammati	0.95788322
68	MP0001905_abnormal_dopamine_level	0.95596584
69	MP0004782_abnormal_surfactant_physiolog	0.95352337
70	MP0008469_abnormal_protein_level	0.95183447
71	MP0003866_abnormal_defecation	0.93556928
72	MP0005636_abnormal_mineral_homeostasis	0.93100989
73	MP0005670_abnormal_white_adipose	0.92390154
74	MP0000490_abnormal_crypts_of	0.90882213
75	MP0009763_increased_sensitivity_to	0.90663488
76	MP0002095_abnormal_skin_pigmentation	0.90658876
77	MP0008872_abnormal_physiological_respon	0.89317980
78	MP0004808_abnormal_hematopoietic_stem	0.87563289
79	MP0008007_abnormal_cellular_replicative	0.85988001
80	MP0006082_CNS_inflammation	0.85813644
81	MP0005410_abnormal_fertilization	0.85406034
82	MP0002653_abnormal_ependyma_morphology	0.84495003
83	MP0003436_decreased_susceptibility_to	0.82729727
84	MP0008873_increased_physiological_sensi	0.82343687
85	MP0005220_abnormal_exocrine_pancreas	0.78376131
86	MP0010386_abnormal_urinary_bladder	0.76373334
87	MP0005319_abnormal_enzyme/_coenzyme	0.74228470
88	MP0001800_abnormal_humoral_immune	0.73060228
89	MP0009643_abnormal_urine_homeostasis	0.71355913
90	MP0000467_abnormal_esophagus_morphology	0.70638008
91	MP0001501_abnormal_sleep_pattern	0.69688320
92	MP0003077_abnormal_cell_cycle	0.68568177
93	MP0005167_abnormal_blood-brain_barrier	0.67973941
94	MP0003172_abnormal_lysosome_physiology	0.66824078
95	MP0001881_abnormal_mammary_gland	0.66544625
96	MP0001664_abnormal_digestion	0.63864446
97	MP0008057_abnormal_DNA_replication	0.61195749
98	MP0004484_altered_response_of	0.59844629
99	MP0001984_abnormal_olfaction	0.57624043
100	MP0005381_digestive/alimentary_phenotyp	0.56842960

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Microvesicular hepatic steatosis (HP:0001414)	5.33545663
2	Abnormality of the heme biosynthetic pathway (HP:0010472)	5.28685745
3	Acute lymphatic leukemia (HP:0006721)	4.04761518
4	Increased serum ferritin (HP:0003281)	3.82213407
5	Impulsivity (HP:0100710)	3.71289642
6	Abnormality of iron homeostasis (HP:0011031)	3.63886108
7	Aplastic anemia (HP:0001915)	3.63156899
8	Elevated erythrocyte sedimentation rate (HP:0003565)	3.61499605
9	Tubulointerstitial nephritis (HP:0001970)	3.51337429
10	Hepatocellular necrosis (HP:0001404)	3.48336696
11	Abnormality of transition element cation homeostasis (HP:0011030)	3.37357431
12	Fatigue (HP:0012378)	3.29660036
13	Hepatic necrosis (HP:0002605)	3.25995373
14	Stomatitis (HP:0010280)	3.23738092
15	Ragged-red muscle fibers (HP:0003200)	3.20890963
16	Dry hair (HP:0011359)	3.15137564
17	Panhypogammaglobulinemia (HP:0003139)	3.09702619
18	Dicarboxylic aciduria (HP:0003215)	3.08577890
19	Abnormality of dicarboxylic acid metabolism (HP:0010995)	3.08577890
20	Cerebral hypomyelination (HP:0006808)	3.06356617
21	Short middle phalanx of the 5th finger (HP:0004220)	3.05440012
22	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	3.04962684
23	Agammaglobulinemia (HP:0004432)	2.99755797
24	Petechiae (HP:0000967)	2.94310856
25	Spastic paraparesis (HP:0002313)	2.91741356
26	Abnormality of B cell number (HP:0010975)	2.89115034
27	B lymphocytopenia (HP:0010976)	2.86712545
28	Premature ovarian failure (HP:0008209)	2.86132181
29	Rhabdomyolysis (HP:0003201)	2.82962967
30	Cupped ribs (HP:0000887)	2.72712106
31	Chromsome breakage (HP:0040012)	2.72164914
32	Granulocytopenia (HP:0001913)	2.68853159
33	Severe combined immunodeficiency (HP:0004430)	2.63518028
34	Mitochondrial inheritance (HP:0001427)	2.62692078
35	Increased IgE level (HP:0003212)	2.56043552
36	Emotional lability (HP:0000712)	2.53740605
37	Neurodegeneration (HP:0002180)	2.52154003
38	Increased muscle lipid content (HP:0009058)	2.46749007
39	3-Methylglutaconic aciduria (HP:0003535)	2.45811475
40	Opisthotonus (HP:0002179)	2.45171574
41	Abnormality of the prostate (HP:0008775)	2.45150860
42	Hypoplasia of the pons (HP:0012110)	2.41294957
43	Lipid accumulation in hepatocytes (HP:0006561)	2.40681096
44	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.38284482
45	Metaphyseal dysplasia (HP:0100255)	2.37216047
46	Abnormal number of erythroid precursors (HP:0012131)	2.36733689
47	Delusions (HP:0000746)	2.36137857
48	CNS demyelination (HP:0007305)	2.34322781
49	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.34021026
50	Prolonged bleeding time (HP:0003010)	2.27761500
51	Combined immunodeficiency (HP:0005387)	2.20499680
52	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.20163245
53	Cerebral palsy (HP:0100021)	2.19406352
54	Autoimmune thrombocytopenia (HP:0001973)	2.18900512
55	Type I transferrin isoform profile (HP:0003642)	2.18637806
56	Recurrent viral infections (HP:0004429)	2.18303062
57	Type II lissencephaly (HP:0007260)	2.18298631
58	Increased CSF lactate (HP:0002490)	2.17782534
59	Abnormality of the pons (HP:0007361)	2.16341697
60	Unsteady gait (HP:0002317)	2.15411741
61	Myositis (HP:0100614)	2.14571657
62	Thrombocytosis (HP:0001894)	2.10466509
63	Abnormal hair laboratory examination (HP:0003328)	2.07283511
64	Medulloblastoma (HP:0002885)	2.03997870
65	Hypertensive crisis (HP:0100735)	2.02603800
66	Abnormality of dental color (HP:0011073)	2.01559156
67	Abnormality of cells of the erythroid lineage (HP:0012130)	2.01152695
68	Neonatal respiratory distress (HP:0002643)	2.01022770
69	Renal Fanconi syndrome (HP:0001994)	1.99833658
70	Exercise intolerance (HP:0003546)	1.99056721
71	Pendular nystagmus (HP:0012043)	1.98556250
72	Chronic otitis media (HP:0000389)	1.96496836
73	Autoimmune hemolytic anemia (HP:0001890)	1.94482355
74	Abnormality of T cell physiology (HP:0011840)	1.94371444
75	Aplasia/Hypoplasia of the scapulae (HP:0006713)	1.94324492
76	Hypoplastic scapulae (HP:0000882)	1.94324492
77	Reticulocytosis (HP:0001923)	1.93986776
78	Abnormality of the anterior horn cell (HP:0006802)	1.92183565
79	Degeneration of anterior horn cells (HP:0002398)	1.92183565
80	Abnormal mitochondria in muscle tissue (HP:0008316)	1.90395575
81	Acute hepatic failure (HP:0006554)	1.89761495
82	Congenital stationary night blindness (HP:0007642)	1.88754038
83	Disproportionate short-trunk short stature (HP:0003521)	1.87846610
84	Thoracic kyphosis (HP:0002942)	1.87291978
85	Abnormality of fatty-acid metabolism (HP:0004359)	1.86993800
86	Renal cortical cysts (HP:0000803)	1.86595764
87	Abnormal pupillary function (HP:0007686)	1.86371509
88	Esophageal neoplasm (HP:0100751)	1.85983018
89	Neoplasm of head and neck (HP:0012288)	1.85983018
90	Short 5th finger (HP:0009237)	1.85090364
91	Brushfield spots (HP:0001088)	1.84380323
92	Ileus (HP:0002595)	1.82824871
93	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	1.81697588
94	Increased serum lactate (HP:0002151)	1.80569948
95	Pili torti (HP:0003777)	1.79570947
96	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.79355801
97	Abnormal protein N-linked glycosylation (HP:0012347)	1.79355801
98	Abnormal protein glycosylation (HP:0012346)	1.79355801
99	Abnormal glycosylation (HP:0012345)	1.79355801
100	Increased intramyocellular lipid droplets (HP:0012240)	1.78987911

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.19715835
2	TESK2	4.07639951
3	TAOK3	4.00268230
4	PIM2	3.93273114
5	SCYL2	3.88695063
6	BCKDK	3.42167518
7	SRPK1	3.30866188
8	KIT	3.25874454
9	FLT3	3.15788012
10	CCNB1	2.57484227
11	NME2	2.55407518
12	KDR	2.21370278
13	MAP4K1	2.14718215
14	TEC	1.76294446
15	MAP3K11	1.63641401
16	PLK4	1.63058029
17	ERN1	1.61232092
18	BTK	1.58518014
19	DYRK3	1.53850694
20	MAP3K6	1.48981254
21	GRK6	1.48665313
22	CSF1R	1.42147031
23	VRK2	1.35709862
24	NUAK1	1.33928381
25	NEK1	1.30947955
26	MAP2K3	1.09610564
27	RPS6KA4	1.09053974
28	TYK2	1.08256099
29	TBK1	1.07364220
30	MAP3K12	1.04323325
31	TNK2	1.02615160
32	MATK	0.99991765
33	ABL2	0.99882802
34	IKBKB	0.95830862
35	MAP2K4	0.92312066
36	MAPKAPK5	0.92048267
37	PBK	0.90501314
38	SYK	0.88465170
39	ITK	0.86745933
40	GRK5	0.86166004
41	RAF1	0.86125657
42	CDC7	0.83410636
43	BMPR1B	0.82334324
44	CDK9	0.81180952
45	CSNK1G3	0.80698333
46	NEK2	0.78920850
47	RPS6KA5	0.77523503
48	ATR	0.75176731
49	TESK1	0.74311238
50	STK16	0.65938203
51	TAOK2	0.63883661
52	MINK1	0.63746541
53	PKN1	0.62805208
54	MAP2K6	0.62486844
55	DAPK1	0.59084905
56	MAP3K5	0.58658271
57	CDK19	0.57051025
58	MKNK1	0.56578064
59	LCK	0.56257611
60	CSNK1A1L	0.56100464
61	MAP3K1	0.55101262
62	ERBB3	0.53765820
63	CSNK1G2	0.53134255
64	DYRK2	0.52639645
65	IRAK2	0.51298135
66	TXK	0.51034692
67	GRK7	0.50262897
68	ARAF	0.48965307
69	DYRK1B	0.48708324
70	RPS6KL1	0.46160158
71	RPS6KC1	0.46160158
72	ADRBK1	0.46036217
73	ZAP70	0.45767789
74	PIM1	0.45473318
75	MAPK11	0.44598622
76	RPS6KA6	0.43757058
77	EIF2AK1	0.43020622
78	AURKA	0.42554888
79	LYN	0.41781136
80	MAPK13	0.41617761
81	CSNK2A2	0.40134432
82	MAPK4	0.38839843
83	FES	0.38740481
84	ATM	0.36803851
85	MAP2K7	0.36567027
86	PRKD1	0.35888123
87	PRKG2	0.35239480
88	CSNK1G1	0.35216614
89	BLK	0.34292751
90	IKBKE	0.34128419
91	CDK8	0.34024424
92	MAPKAPK3	0.31832310
93	CDK4	0.31078596
94	LIMK1	0.30994806
95	CSNK2A1	0.28749887
96	RPS6KB2	0.28287632
97	CDK7	0.27315836
98	SIK2	0.27281010
99	MAPKAPK2	0.26903317
100	DAPK3	0.26817686

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Base excision repair_Homo sapiens_hsa03410	4.07155718
2	DNA replication_Homo sapiens_hsa03030	3.21276406
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.91406904
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.87134908
5	Homologous recombination_Homo sapiens_hsa03440	2.76959868
6	Ribosome_Homo sapiens_hsa03010	2.64215762
7	Butanoate metabolism_Homo sapiens_hsa00650	2.36434390
8	Sulfur relay system_Homo sapiens_hsa04122	2.26302025
9	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.20967126
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.12145332
11	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.04656827
12	Mismatch repair_Homo sapiens_hsa03430	2.02431634
13	Pyrimidine metabolism_Homo sapiens_hsa00240	2.01133037
14	Nucleotide excision repair_Homo sapiens_hsa03420	1.98655578
15	Fanconi anemia pathway_Homo sapiens_hsa03460	1.96724957
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.93556105
17	Primary immunodeficiency_Homo sapiens_hsa05340	1.87038289
18	Peroxisome_Homo sapiens_hsa04146	1.84446965
19	Non-homologous end-joining_Homo sapiens_hsa03450	1.82340086
20	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.77981547
21	Fatty acid degradation_Homo sapiens_hsa00071	1.74084559
22	Pentose phosphate pathway_Homo sapiens_hsa00030	1.73601513
23	Parkinsons disease_Homo sapiens_hsa05012	1.62426514
24	Fatty acid metabolism_Homo sapiens_hsa01212	1.61996394
25	RNA polymerase_Homo sapiens_hsa03020	1.61333302
26	Carbon metabolism_Homo sapiens_hsa01200	1.59913852
27	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.57285020
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.57065352
29	Oxidative phosphorylation_Homo sapiens_hsa00190	1.56897865
30	Propanoate metabolism_Homo sapiens_hsa00640	1.41613541
31	Asthma_Homo sapiens_hsa05310	1.32300703
32	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.31524718
33	Purine metabolism_Homo sapiens_hsa00230	1.28254611
34	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.25493757
35	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.22896299
36	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.22194206
37	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.20897309
38	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.17672308
39	One carbon pool by folate_Homo sapiens_hsa00670	1.16322374
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.14894920
41	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.13578325
42	Lysine degradation_Homo sapiens_hsa00310	1.13383260
43	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.08703009
44	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.03590966
45	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.01423190
46	Spliceosome_Homo sapiens_hsa03040	1.00437313
47	Huntingtons disease_Homo sapiens_hsa05016	1.00428266
48	Proteasome_Homo sapiens_hsa03050	0.96316755
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.89705175
50	Alzheimers disease_Homo sapiens_hsa05010	0.86409981
51	Fatty acid elongation_Homo sapiens_hsa00062	0.86169007
52	Leishmaniasis_Homo sapiens_hsa05140	0.85231124
53	Herpes simplex infection_Homo sapiens_hsa05168	0.84307087
54	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.84285625
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.83644113
56	Metabolic pathways_Homo sapiens_hsa01100	0.80088208
57	RNA degradation_Homo sapiens_hsa03018	0.78474087
58	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.76501685
59	RNA transport_Homo sapiens_hsa03013	0.75959059
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72206610
61	Pyruvate metabolism_Homo sapiens_hsa00620	0.70816619
62	Allograft rejection_Homo sapiens_hsa05330	0.70225216
63	Glutathione metabolism_Homo sapiens_hsa00480	0.67984265
64	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.67045322
65	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.65952342
66	Platelet activation_Homo sapiens_hsa04611	0.63532496
67	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.63087358
68	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.62508838
69	Pertussis_Homo sapiens_hsa05133	0.62187558
70	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.60690136
71	Graft-versus-host disease_Homo sapiens_hsa05332	0.60008676
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59292247
73	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.58594156
74	Tyrosine metabolism_Homo sapiens_hsa00350	0.57030794
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56970515
76	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.56068072
77	Antigen processing and presentation_Homo sapiens_hsa04612	0.54300457
78	Histidine metabolism_Homo sapiens_hsa00340	0.52698602
79	Cell cycle_Homo sapiens_hsa04110	0.45614724
80	Basal transcription factors_Homo sapiens_hsa03022	0.44059827
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43504520
82	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.42342520
83	Type I diabetes mellitus_Homo sapiens_hsa04940	0.41738935
84	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.40929146
85	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.39079650
86	Folate biosynthesis_Homo sapiens_hsa00790	0.38990813
87	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.38670545
88	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38313271
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.37354740
90	Olfactory transduction_Homo sapiens_hsa04740	0.37188899
91	Sulfur metabolism_Homo sapiens_hsa00920	0.33191820
92	Nitrogen metabolism_Homo sapiens_hsa00910	0.32757816
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.32699103
94	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.30435812
95	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.30028927
96	Chemical carcinogenesis_Homo sapiens_hsa05204	0.27249714
97	Salivary secretion_Homo sapiens_hsa04970	0.23864027
98	Circadian rhythm_Homo sapiens_hsa04710	0.22940570
99	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.21242755
100	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.20105424

RARRES2P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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