ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	6.57111419
2	thrombin receptor signaling pathway (GO:0070493)	5.96411805
3	neutrophil activation involved in immune response (GO:0002283)	5.49175655
4	platelet dense granule organization (GO:0060155)	5.06448352
5	blood coagulation, intrinsic pathway (GO:0007597)	4.54991307
6	negative regulation of heart rate (GO:0010459)	4.43965976
7	angiogenesis involved in wound healing (GO:0060055)	4.37415814
8	positive regulation of mast cell activation (GO:0033005)	4.21157243
9	positive regulation of endothelial cell differentiation (GO:0045603)	4.19111891
10	negative regulation of response to food (GO:0032096)	4.13409544
11	negative regulation of appetite (GO:0032099)	4.13409544
12	adenosine receptor signaling pathway (GO:0001973)	4.09635900
13	heme transport (GO:0015886)	4.05120149
14	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.94385142
15	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.93634675
16	regulation of platelet aggregation (GO:0090330)	3.93558924
17	aggressive behavior (GO:0002118)	3.73189808
18	regulation of female receptivity (GO:0045924)	3.69676464
19	platelet aggregation (GO:0070527)	3.69338518
20	fucose catabolic process (GO:0019317)	3.61858358
21	L-fucose metabolic process (GO:0042354)	3.61858358
22	L-fucose catabolic process (GO:0042355)	3.61858358
23	fusion of sperm to egg plasma membrane (GO:0007342)	3.60240463
24	regulation of platelet activation (GO:0010543)	3.58034382
25	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	3.51368775
26	relaxation of smooth muscle (GO:0044557)	3.49807172
27	autophagic vacuole fusion (GO:0000046)	3.45368004
28	negative regulation of thymocyte apoptotic process (GO:0070244)	3.38253486
29	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.37726960
30	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	3.36640347
31	purinergic receptor signaling pathway (GO:0035587)	3.36524186
32	regulation of integrin-mediated signaling pathway (GO:2001044)	3.32257492
33	low-density lipoprotein particle remodeling (GO:0034374)	3.25471632
34	positive regulation of mast cell activation involved in immune response (GO:0033008)	3.24380961
35	positive regulation of mast cell degranulation (GO:0043306)	3.24380961
36	regulation of Golgi to plasma membrane protein transport (GO:0042996)	3.20465800
37	sequestering of actin monomers (GO:0042989)	3.17438423
38	beta-amyloid metabolic process (GO:0050435)	3.14148566
39	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)	3.10166632
40	regulation of glutamate secretion (GO:0014048)	3.06901344
41	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.06579902
42	leukocyte migration involved in inflammatory response (GO:0002523)	3.04823146
43	fibroblast migration (GO:0010761)	3.04702824
44	female mating behavior (GO:0060180)	3.04211094
45	regulation of T-helper 1 cell differentiation (GO:0045625)	3.03361527
46	positive regulation of B cell differentiation (GO:0045579)	3.00803822
47	maternal behavior (GO:0042711)	2.98818407
48	mitochondrial calcium ion transport (GO:0006851)	2.98788392
49	long-chain fatty acid biosynthetic process (GO:0042759)	2.96544046
50	multicellular organism reproduction (GO:0032504)	2.95027553
51	dopamine transport (GO:0015872)	2.92267547
52	negative regulation of norepinephrine secretion (GO:0010700)	2.91761342
53	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.89722596
54	base-excision repair, AP site formation (GO:0006285)	2.88464832
55	cellular biogenic amine biosynthetic process (GO:0042401)	2.87874215
56	monoamine transport (GO:0015844)	2.86700086
57	neutrophil activation (GO:0042119)	2.86473160
58	regulation of cilium movement (GO:0003352)	2.84287689
59	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.83642378
60	polyamine biosynthetic process (GO:0006596)	2.83556435
61	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	2.80420163
62	regulation of penile erection (GO:0060405)	2.79554110
63	regulation of endothelial cell differentiation (GO:0045601)	2.79393584
64	iron coordination entity transport (GO:1901678)	2.78079527
65	membrane invagination (GO:0010324)	2.76854523
66	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.76332903
67	sialylation (GO:0097503)	2.73666190
68	positive regulation of amino acid transport (GO:0051957)	2.73068056
69	amine biosynthetic process (GO:0009309)	2.72720837
70	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.72474384
71	positive regulation of systemic arterial blood pressure (GO:0003084)	2.71192581
72	iron-sulfur cluster assembly (GO:0016226)	2.68250028
73	metallo-sulfur cluster assembly (GO:0031163)	2.68250028
74	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	2.66834235
75	negative regulation of heart contraction (GO:0045822)	2.66397196
76	plasma membrane fusion (GO:0045026)	2.66030990
77	homotypic cell-cell adhesion (GO:0034109)	2.65214117
78	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.64352944
79	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.64054127
80	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.64054127
81	mitochondrial calcium ion homeostasis (GO:0051560)	2.63714195
82	positive regulation of Rho protein signal transduction (GO:0035025)	2.63440948
83	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.61730188
84	negative regulation of platelet activation (GO:0010544)	2.61050040
85	polyamine metabolic process (GO:0006595)	2.59352074
86	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.55421998
87	deoxyribonucleotide catabolic process (GO:0009264)	2.54445333
88	organelle membrane fusion (GO:0090174)	2.53235579
89	cellular biogenic amine catabolic process (GO:0042402)	2.52955688
90	amine catabolic process (GO:0009310)	2.52955688
91	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	2.52062758
92	negative regulation of calcium ion transmembrane transport (GO:1903170)	2.52062758
93	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.51244946
94	melanosome transport (GO:0032402)	2.50951914
95	xenobiotic catabolic process (GO:0042178)	2.50643008
96	endosome to melanosome transport (GO:0035646)	2.49176814
97	endosome to pigment granule transport (GO:0043485)	2.49176814
98	negative regulation of protein localization to cell surface (GO:2000009)	2.48976546
99	negative regulation of muscle contraction (GO:0045932)	2.48497582
100	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.48357307

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	6.13556518
2	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	4.12267769
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.33418524
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.16742725
5	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	3.07697740
6	GBX2_23144817_ChIP-Seq_PC3_Human	3.01625660
7	SCL_19346495_ChIP-Seq_HPC-7_Human	2.91695013
8	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.89696055
9	IRF1_19129219_ChIP-ChIP_H3396_Human	2.76245993
10	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	2.49433203
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.27780045
12	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	2.25235316
13	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.15479169
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.11543906
15	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.06609637
16	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.04815281
17	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.88560477
18	ZNF274_21170338_ChIP-Seq_K562_Hela	1.86630446
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.85895866
20	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.84450041
21	VDR_22108803_ChIP-Seq_LS180_Human	1.84422588
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.83854367
23	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.82017765
24	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.81568163
25	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.73182967
26	GATA1_19941826_ChIP-Seq_K562_Human	1.65726662
27	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.61941684
28	P300_19829295_ChIP-Seq_ESCs_Human	1.60423733
29	EWS_26573619_Chip-Seq_HEK293_Human	1.57668932
30	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.51039614
31	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.42068542
32	AR_20517297_ChIP-Seq_VCAP_Human	1.41349855
33	SOX2_19829295_ChIP-Seq_ESCs_Human	1.41207833
34	NANOG_19829295_ChIP-Seq_ESCs_Human	1.41207833
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40458914
36	FUS_26573619_Chip-Seq_HEK293_Human	1.39542994
37	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.38039358
38	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.34984193
39	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.33937576
40	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.33848877
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.31678668
42	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.29678063
43	HTT_18923047_ChIP-ChIP_STHdh_Human	1.24249467
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23857295
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23857295
46	GATA2_19941826_ChIP-Seq_K562_Human	1.23372465
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.23285145
48	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.22803974
49	NANOG_20526341_ChIP-Seq_ESCs_Human	1.16808467
50	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.16702515
51	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.16107349
52	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.16000991
53	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15105051
54	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.14837451
55	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.13470860
56	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12954418
57	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12663375
58	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.12424022
59	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.10954790
60	SPI1_20517297_ChIP-Seq_HL60_Human	1.09994834
61	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.09313257
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.05798546
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.05798546
64	GATA1_22025678_ChIP-Seq_K562_Human	1.05546552
65	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.05454755
66	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.04460293
67	ERG_20517297_ChIP-Seq_VCAP_Human	1.03665555
68	AR_25329375_ChIP-Seq_VCAP_Human	1.03497773
69	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.03462383
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03271891
71	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.03248501
72	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.03127042
73	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.02367784
74	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.02088221
75	SMAD4_21799915_ChIP-Seq_A2780_Human	1.00680097
76	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.00328387
77	GATA3_26560356_Chip-Seq_TH1_Human	1.00055943
78	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99089330
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98952055
80	SPI1_23127762_ChIP-Seq_K562_Human	0.98897192
81	BCL6_27268052_Chip-Seq_Bcells_Human	0.98464205
82	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95780965
83	MYC_18940864_ChIP-ChIP_HL60_Human	0.95764106
84	GATA3_26560356_Chip-Seq_TH2_Human	0.92680493
85	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.91993671
86	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.91872581
87	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90725869
88	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.89132650
89	HOXB7_26014856_ChIP-Seq_BT474_Human	0.88957133
90	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.88840683
91	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.88421430
92	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.87916983
93	MYC_19829295_ChIP-Seq_ESCs_Human	0.86919603
94	STAT3_23295773_ChIP-Seq_U87_Human	0.86437456
95	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.86383424
96	P53_21459846_ChIP-Seq_SAOS-2_Human	0.85494000
97	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.84852954
98	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.84791308
99	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.84401907
100	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.83785269

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005464_abnormal_platelet_physiology	6.73993326
2	MP0002736_abnormal_nociception_after	3.05141261
3	MP0002102_abnormal_ear_morphology	2.90853475
4	MP0000465_gastrointestinal_hemorrhage	2.69305858
5	MP0008004_abnormal_stomach_pH	2.67673212
6	MP0003646_muscle_fatigue	2.62650726
7	MP0005171_absent_coat_pigmentation	2.40203511
8	MP0001968_abnormal_touch/_nociception	2.39340166
9	MP0000372_irregular_coat_pigmentation	2.36009787
10	MP0003136_yellow_coat_color	2.28503001
11	MP0009697_abnormal_copulation	2.24125226
12	MP0003045_fibrosis	2.21685272
13	MP0009046_muscle_twitch	2.13683998
14	MP0005084_abnormal_gallbladder_morpholo	2.09062741
15	MP0003724_increased_susceptibility_to	2.08050061
16	MP0000343_altered_response_to	2.03718273
17	MP0001529_abnormal_vocalization	2.02673438
18	MP0000230_abnormal_systemic_arterial	1.93693395
19	MP0004147_increased_porphyrin_level	1.93617154
20	MP0002653_abnormal_ependyma_morphology	1.90180786
21	MP0005083_abnormal_biliary_tract	1.90090885
22	MP0001984_abnormal_olfaction	1.87628693
23	MP0008775_abnormal_heart_ventricle	1.82390156
24	MP0008872_abnormal_physiological_respon	1.80591372
25	MP0003638_abnormal_response/metabolism_	1.77155511
26	MP0005397_hematopoietic_system_phenotyp	1.70755342
27	MP0001545_abnormal_hematopoietic_system	1.70755342
28	MP0005410_abnormal_fertilization	1.69805297
29	MP0006276_abnormal_autonomic_nervous	1.69796810
30	MP0004142_abnormal_muscle_tone	1.69753843
31	MP0005253_abnormal_eye_physiology	1.64749100
32	MP0005646_abnormal_pituitary_gland	1.62804432
33	MP0003122_maternal_imprinting	1.61697697
34	MP0000015_abnormal_ear_pigmentation	1.56425891
35	MP0005174_abnormal_tail_pigmentation	1.50607391
36	MP0002733_abnormal_thermal_nociception	1.45330825
37	MP0001905_abnormal_dopamine_level	1.33168146
38	MP0002148_abnormal_hypersensitivity_rea	1.32666964
39	MP0005645_abnormal_hypothalamus_physiol	1.30284139
40	MP0002132_abnormal_respiratory_system	1.26990416
41	MP0005551_abnormal_eye_electrophysiolog	1.17524946
42	MP0006036_abnormal_mitochondrial_physio	1.16059314
43	MP0008875_abnormal_xenobiotic_pharmacok	1.15573762
44	MP0004484_altered_response_of	1.12428548
45	MP0004510_myositis	1.10127649
46	MP0002735_abnormal_chemical_nociception	1.07247620
47	MP0001664_abnormal_digestion	1.04457190
48	MP0001835_abnormal_antigen_presentation	1.04098839
49	MP0002837_dystrophic_cardiac_calcinosis	1.03274555
50	MP0002095_abnormal_skin_pigmentation	1.01999546
51	MP0005167_abnormal_blood-brain_barrier	1.00626166
52	MP0001970_abnormal_pain_threshold	1.00546761
53	MP0002332_abnormal_exercise_endurance	0.99670920
54	MP0003303_peritoneal_inflammation	0.98274258
55	MP0004085_abnormal_heartbeat	0.98226469
56	MP0006054_spinal_hemorrhage	0.97337081
57	MP0003656_abnormal_erythrocyte_physiolo	0.97194492
58	MP0001963_abnormal_hearing_physiology	0.95586984
59	MP0008789_abnormal_olfactory_epithelium	0.95255228
60	MP0010329_abnormal_lipoprotein_level	0.93524542
61	MP0005584_abnormal_enzyme/coenzyme_acti	0.91576866
62	MP0005394_taste/olfaction_phenotype	0.91285624
63	MP0005499_abnormal_olfactory_system	0.91285624
64	MP0006292_abnormal_olfactory_placode	0.90598938
65	MP0002572_abnormal_emotion/affect_behav	0.89800833
66	MP0009764_decreased_sensitivity_to	0.85661993
67	MP0000383_abnormal_hair_follicle	0.85087197
68	MP0001764_abnormal_homeostasis	0.84723085
69	MP0001663_abnormal_digestive_system	0.84224655
70	MP0003137_abnormal_impulse_conducting	0.83970468
71	MP0005058_abnormal_lysosome_morphology	0.83744193
72	MP0004215_abnormal_myocardial_fiber	0.83686648
73	MP0002067_abnormal_sensory_capabilities	0.82844573
74	MP0008569_lethality_at_weaning	0.81929272
75	MP0003828_pulmonary_edema	0.79924657
76	MP0000427_abnormal_hair_cycle	0.79219395
77	MP0001986_abnormal_taste_sensitivity	0.76845362
78	MP0003567_abnormal_fetal_cardiomyocyte	0.75630382
79	MP0004130_abnormal_muscle_cell	0.74909205
80	MP0002557_abnormal_social/conspecific_i	0.74654803
81	MP0005075_abnormal_melanosome_morpholog	0.74547473
82	MP0006072_abnormal_retinal_apoptosis	0.73496529
83	MP0002272_abnormal_nervous_system	0.72952664
84	MP0009763_increased_sensitivity_to	0.72411344
85	MP0002090_abnormal_vision	0.71720947
86	MP0004084_abnormal_cardiac_muscle	0.70863582
87	MP0009745_abnormal_behavioral_response	0.69988762
88	MP0003329_amyloid_beta_deposits	0.69864853
89	MP0005367_renal/urinary_system_phenotyp	0.69728127
90	MP0000516_abnormal_urinary_system	0.69728127
91	MP0009642_abnormal_blood_homeostasis	0.69540320
92	MP0003718_maternal_effect	0.69036847
93	MP0005385_cardiovascular_system_phenoty	0.67980856
94	MP0001544_abnormal_cardiovascular_syste	0.67980856
95	MP0005535_abnormal_body_temperature	0.67804412
96	MP0005670_abnormal_white_adipose	0.67783562
97	MP0002972_abnormal_cardiac_muscle	0.65883071
98	MP0000026_abnormal_inner_ear	0.65083528
99	MP0000689_abnormal_spleen_morphology	0.64946293
100	MP0005636_abnormal_mineral_homeostasis	0.64254558

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged bleeding time (HP:0003010)	7.52397876
2	Petechiae (HP:0000967)	7.48642791
3	Increased mean platelet volume (HP:0011877)	6.92699654
4	Menorrhagia (HP:0000132)	6.78956426
5	Abnormal platelet volume (HP:0011876)	6.39199742
6	Purpura (HP:0000979)	5.78714855
7	Epistaxis (HP:0000421)	4.99695755
8	Cutaneous melanoma (HP:0012056)	4.82949589
9	Gingival bleeding (HP:0000225)	4.68078270
10	Hypochromic microcytic anemia (HP:0004840)	4.54759243
11	Hyperlipoproteinemia (HP:0010980)	4.33263304
12	Abnormal pupillary function (HP:0007686)	3.56799643
13	Abnormal platelet function (HP:0011869)	3.49092980
14	Impaired platelet aggregation (HP:0003540)	3.49092980
15	Congenital stationary night blindness (HP:0007642)	3.33187494
16	Hemiparesis (HP:0001269)	3.12126397
17	Poikilocytosis (HP:0004447)	3.01768997
18	Decreased central vision (HP:0007663)	3.01766846
19	Abnormality of lateral ventricle (HP:0030047)	2.97898904
20	Male infertility (HP:0003251)	2.91542709
21	Abnormal auditory evoked potentials (HP:0006958)	2.88111865
22	Dyschromatopsia (HP:0007641)	2.82958051
23	Failure to thrive in infancy (HP:0001531)	2.68743150
24	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.65352549
25	Disproportionate short-trunk short stature (HP:0003521)	2.62599530
26	Acanthocytosis (HP:0001927)	2.58484422
27	Abolished electroretinogram (ERG) (HP:0000550)	2.48749782
28	Vacuolated lymphocytes (HP:0001922)	2.46477866
29	Thyroid-stimulating hormone excess (HP:0002925)	2.36709216
30	Polyphagia (HP:0002591)	2.35580981
31	Febrile seizures (HP:0002373)	2.31561572
32	Tongue fasciculations (HP:0001308)	2.30111156
33	Stomatitis (HP:0010280)	2.29817764
34	Abnormality of midbrain morphology (HP:0002418)	2.29335608
35	Molar tooth sign on MRI (HP:0002419)	2.29335608
36	Albinism (HP:0001022)	2.25777879
37	Paralysis (HP:0003470)	2.21503242
38	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.18292712
39	Abnormality of alanine metabolism (HP:0010916)	2.16145032
40	Hyperalaninemia (HP:0003348)	2.16145032
41	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.16145032
42	Exercise-induced muscle cramps (HP:0003710)	2.14464425
43	Episodic fever (HP:0001954)	2.13143400
44	Bruising susceptibility (HP:0000978)	2.12455097
45	Retinal dysplasia (HP:0007973)	2.12269160
46	Dysdiadochokinesis (HP:0002075)	2.05750325
47	Bifid tongue (HP:0010297)	2.05180551
48	Medial flaring of the eyebrow (HP:0010747)	1.93823498
49	Nephronophthisis (HP:0000090)	1.89973772
50	Abnormality of the common coagulation pathway (HP:0010990)	1.88928588
51	Muscle fibrillation (HP:0010546)	1.88752218
52	Generalized aminoaciduria (HP:0002909)	1.88693824
53	Arthropathy (HP:0003040)	1.86781932
54	Attenuation of retinal blood vessels (HP:0007843)	1.86650860
55	Progressive inability to walk (HP:0002505)	1.85493428
56	Abnormal biliary tract physiology (HP:0012439)	1.85452391
57	Bile duct proliferation (HP:0001408)	1.85452391
58	Acute necrotizing encephalopathy (HP:0006965)	1.84840814
59	Dysautonomia (HP:0002459)	1.84058847
60	Heterochromia iridis (HP:0001100)	1.83826100
61	Hepatosplenomegaly (HP:0001433)	1.82925675
62	Pancreatic islet-cell hyperplasia (HP:0004510)	1.81430139
63	Absent epiphyses (HP:0010577)	1.79517030
64	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.79517030
65	Generalized hypopigmentation (HP:0007513)	1.78509959
66	Spontaneous hematomas (HP:0007420)	1.78404662
67	Diplopia (HP:0000651)	1.77483617
68	Abnormality of binocular vision (HP:0011514)	1.77483617
69	Abnormal mitochondria in muscle tissue (HP:0008316)	1.75425067
70	Upper limb muscle weakness (HP:0003484)	1.74430221
71	Congenital primary aphakia (HP:0007707)	1.73270129
72	Opisthotonus (HP:0002179)	1.72414895
73	Progressive macrocephaly (HP:0004481)	1.71589019
74	Renal cortical cysts (HP:0000803)	1.71184937
75	Abnormal ciliary motility (HP:0012262)	1.69206370
76	Encephalitis (HP:0002383)	1.68233856
77	Ketosis (HP:0001946)	1.67609556
78	Spontaneous abortion (HP:0005268)	1.66732578
79	Dysostosis multiplex (HP:0000943)	1.66685887
80	Gait imbalance (HP:0002141)	1.66577682
81	Hypoplasia of the iris (HP:0007676)	1.65897262
82	True hermaphroditism (HP:0010459)	1.63987393
83	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.63398318
84	Hypoplasia of the brainstem (HP:0002365)	1.63398318
85	Dyskinesia (HP:0100660)	1.63174582
86	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.62709578
87	Hypoplasia of the fovea (HP:0007750)	1.62709578
88	Progressive microcephaly (HP:0000253)	1.61425582
89	Abnormal respiratory motile cilium morphology (HP:0005938)	1.61337924
90	Abnormal respiratory epithelium morphology (HP:0012253)	1.61337924
91	Intention tremor (HP:0002080)	1.60991050
92	Pachygyria (HP:0001302)	1.57673274
93	Congenital, generalized hypertrichosis (HP:0004540)	1.57273333
94	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.56892742
95	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.54802885
96	Abnormality of the anterior horn cell (HP:0006802)	1.54479469
97	Degeneration of anterior horn cells (HP:0002398)	1.54479469
98	Hyperthyroidism (HP:0000836)	1.54329150
99	Pancreatic cysts (HP:0001737)	1.52343578
100	Optic disc pallor (HP:0000543)	1.51918711

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	4.28121867
2	TRIM28	4.00320839
3	EIF2AK1	2.75283305
4	ADRBK2	2.65165315
5	TAOK3	2.57450556
6	BMPR1B	2.49470234
7	NUAK1	2.47537649
8	GRK1	2.29921283
9	MAP4K2	2.16564835
10	TESK2	2.14887995
11	PTK2B	2.10045612
12	SIK3	2.04573174
13	GRK5	1.97965430
14	MST4	1.97190231
15	FRK	1.92928795
16	BCR	1.87391364
17	BMX	1.87316076
18	ACVR1B	1.85769983
19	MAP2K7	1.78804020
20	BCKDK	1.74840119
21	GRK7	1.66456626
22	GRK6	1.65506378
23	MAP3K4	1.64352076
24	MAPK13	1.55515938
25	CSNK1G3	1.54504502
26	PIK3CG	1.48460345
27	RIPK4	1.44885842
28	TEC	1.39157844
29	ADRBK1	1.37355381
30	CSNK1G2	1.36782047
31	BTK	1.36109184
32	SCYL2	1.32377068
33	MYLK	1.30699776
34	CSNK1A1L	1.25517563
35	SYK	1.25450933
36	PIM2	1.24602112
37	EPHA3	1.24204375
38	OXSR1	1.16742612
39	PLK2	1.13751287
40	ZAK	1.12027938
41	LATS1	1.10370881
42	FGR	1.08563355
43	DYRK1A	1.08177165
44	CSNK1G1	1.04540533
45	FGFR3	1.03174442
46	STK3	1.01848125
47	MATK	0.99104664
48	IKBKB	0.90366571
49	LMTK2	0.87351877
50	CSF1R	0.85361889
51	PINK1	0.82935813
52	LIMK1	0.78648472
53	TNK2	0.70950754
54	STK16	0.68090438
55	WNK3	0.66311367
56	MAPK15	0.65096998
57	VRK1	0.64818025
58	BMPR2	0.64799369
59	FER	0.64465639
60	RPS6KA4	0.64363540
61	PAK1	0.62995500
62	KDR	0.60961341
63	RPS6KA5	0.59925506
64	LYN	0.58283358
65	CAMKK2	0.57859558
66	TESK1	0.57550414
67	ERBB3	0.56987014
68	HCK	0.56075945
69	DYRK1B	0.55869536
70	DAPK2	0.55473700
71	CAMK2A	0.53438093
72	PRKD1	0.53058022
73	MAP3K6	0.52715711
74	DYRK2	0.52682714
75	DYRK3	0.51791845
76	CSNK1D	0.47837027
77	PRKACG	0.47313498
78	CDK14	0.46307389
79	PRKCE	0.43433106
80	FGFR2	0.43401689
81	RET	0.42922213
82	AURKA	0.42026256
83	ZAP70	0.41863402
84	PKN1	0.41724592
85	PRKACA	0.40468275
86	ITK	0.40202287
87	EPHB2	0.39976775
88	PLK3	0.36737297
89	MAP3K5	0.36015367
90	LCK	0.34855002
91	TNIK	0.33308305
92	CSNK1A1	0.33305001
93	PRKG1	0.32744928
94	PRKACB	0.32462228
95	PDK2	0.32306652
96	MINK1	0.31720057
97	CAMK2G	0.31678813
98	NTRK2	0.29003042
99	MARK3	0.28814347
100	DAPK3	0.27508441

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Platelet activation_Homo sapiens_hsa04611	3.97911331
2	Collecting duct acid secretion_Homo sapiens_hsa04966	3.51329331
3	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.74300121
4	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.74279369
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.59933811
6	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.40991904
7	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.40189240
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.18951920
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.15655774
10	Fatty acid elongation_Homo sapiens_hsa00062	2.14725374
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.94259519
12	Morphine addiction_Homo sapiens_hsa05032	1.93541859
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.92761149
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.89816402
15	Phototransduction_Homo sapiens_hsa04744	1.78457183
16	GABAergic synapse_Homo sapiens_hsa04727	1.73195938
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.72994283
18	Olfactory transduction_Homo sapiens_hsa04740	1.71672913
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.64947691
20	Sulfur metabolism_Homo sapiens_hsa00920	1.59279086
21	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.55539156
22	Alcoholism_Homo sapiens_hsa05034	1.54445250
23	Pentose phosphate pathway_Homo sapiens_hsa00030	1.52254933
24	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.52136182
25	Serotonergic synapse_Homo sapiens_hsa04726	1.50931964
26	Glycerolipid metabolism_Homo sapiens_hsa00561	1.48077687
27	Butanoate metabolism_Homo sapiens_hsa00650	1.41813531
28	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.39882190
29	Glutathione metabolism_Homo sapiens_hsa00480	1.37844201
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.36870237
31	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.31409402
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.28470127
33	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.28346815
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.25150812
35	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.22304281
36	Nicotine addiction_Homo sapiens_hsa05033	1.21359054
37	Taste transduction_Homo sapiens_hsa04742	1.19488858
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.17033519
39	Peroxisome_Homo sapiens_hsa04146	1.16855139
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.13454170
41	Parkinsons disease_Homo sapiens_hsa05012	1.10534893
42	Regulation of autophagy_Homo sapiens_hsa04140	1.07086752
43	Oxidative phosphorylation_Homo sapiens_hsa00190	1.06829299
44	Sphingolipid metabolism_Homo sapiens_hsa00600	1.03780568
45	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.03587976
46	Shigellosis_Homo sapiens_hsa05131	1.02137188
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.98975169
48	ECM-receptor interaction_Homo sapiens_hsa04512	0.98129414
49	Circadian entrainment_Homo sapiens_hsa04713	0.97330928
50	Gap junction_Homo sapiens_hsa04540	0.97227686
51	ABC transporters_Homo sapiens_hsa02010	0.96621877
52	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.91865600
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.91286750
54	Vibrio cholerae infection_Homo sapiens_hsa05110	0.87973837
55	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.87834502
56	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.83424756
57	Base excision repair_Homo sapiens_hsa03410	0.82898759
58	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.82460224
59	Phagosome_Homo sapiens_hsa04145	0.80922802
60	Purine metabolism_Homo sapiens_hsa00230	0.79666887
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.78070501
62	Other glycan degradation_Homo sapiens_hsa00511	0.77632832
63	Calcium signaling pathway_Homo sapiens_hsa04020	0.76357825
64	Tryptophan metabolism_Homo sapiens_hsa00380	0.74288587
65	Sulfur relay system_Homo sapiens_hsa04122	0.72046111
66	Caffeine metabolism_Homo sapiens_hsa00232	0.69924676
67	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.68696373
68	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67000789
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65691364
70	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.65603615
71	Retinol metabolism_Homo sapiens_hsa00830	0.64879533
72	Endocytosis_Homo sapiens_hsa04144	0.63514688
73	Renin-angiotensin system_Homo sapiens_hsa04614	0.63476052
74	Fanconi anemia pathway_Homo sapiens_hsa03460	0.61704584
75	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.61003575
76	Protein export_Homo sapiens_hsa03060	0.59623290
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59541892
78	Lysosome_Homo sapiens_hsa04142	0.57817931
79	Metabolic pathways_Homo sapiens_hsa01100	0.57726321
80	Rheumatoid arthritis_Homo sapiens_hsa05323	0.57401410
81	Basal transcription factors_Homo sapiens_hsa03022	0.57348551
82	Long-term depression_Homo sapiens_hsa04730	0.53988932
83	Ether lipid metabolism_Homo sapiens_hsa00565	0.53625685
84	Glutamatergic synapse_Homo sapiens_hsa04724	0.52709801
85	Chemokine signaling pathway_Homo sapiens_hsa04062	0.49224990
86	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.48872588
87	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.47439262
88	Tyrosine metabolism_Homo sapiens_hsa00350	0.46551674
89	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.38164844
90	Pyrimidine metabolism_Homo sapiens_hsa00240	0.36502677
91	Ras signaling pathway_Homo sapiens_hsa04014	0.34558062
92	Huntingtons disease_Homo sapiens_hsa05016	0.34006792
93	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.33649188
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33623064
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.29717800
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.28703971
97	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.27750303
98	Galactose metabolism_Homo sapiens_hsa00052	0.23847980
99	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.23716202
100	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.23134237

RARRES2P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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