RARRES3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.60132536
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.42007321
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.07001209
4antigen processing and presentation of endogenous antigen (GO:0019883)6.06284669
5negative regulation of cell killing (GO:0031342)5.76365971
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.76365971
7positive regulation of gamma-delta T cell activation (GO:0046645)4.91787163
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.37164085
9negative T cell selection (GO:0043383)4.33062363
10positive thymic T cell selection (GO:0045059)4.24181375
11cytidine metabolic process (GO:0046087)4.18559970
12cytidine catabolic process (GO:0006216)4.18559970
13cytidine deamination (GO:0009972)4.18559970
14negative thymic T cell selection (GO:0045060)4.12607223
15type I interferon signaling pathway (GO:0060337)4.02396251
16cellular response to type I interferon (GO:0071357)4.02396251
17positive regulation of T cell mediated cytotoxicity (GO:0001916)4.00892181
18regulation of regulatory T cell differentiation (GO:0045589)4.00663458
19regulation of T cell mediated cytotoxicity (GO:0001914)4.00583291
20response to type I interferon (GO:0034340)3.99239234
21regulation of B cell receptor signaling pathway (GO:0050855)3.97636753
22positive T cell selection (GO:0043368)3.93516979
23regulation of gamma-delta T cell differentiation (GO:0045586)3.91386685
24immunoglobulin mediated immune response (GO:0016064)3.89345410
25leukocyte aggregation (GO:0070486)3.83801105
26response to interferon-beta (GO:0035456)3.80929792
27T cell migration (GO:0072678)3.79975719
28regulation of gamma-delta T cell activation (GO:0046643)3.74789072
29pyrimidine ribonucleoside catabolic process (GO:0046133)3.74590941
30regulation of T cell tolerance induction (GO:0002664)3.73421823
31cellular response to interleukin-15 (GO:0071350)3.73371710
32positive regulation of tolerance induction (GO:0002645)3.71830407
33regulation of tolerance induction (GO:0002643)3.67429850
34regulation of natural killer cell mediated immunity (GO:0002715)3.64681423
35regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.64681423
36thymic T cell selection (GO:0045061)3.63933147
37positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.62858460
38detection of bacterium (GO:0016045)3.61746930
39regulation of leukocyte mediated cytotoxicity (GO:0001910)3.60360724
40response to interleukin-15 (GO:0070672)3.56570324
41T cell selection (GO:0045058)3.54111038
42negative regulation of lymphocyte mediated immunity (GO:0002707)3.53156971
43interferon-gamma-mediated signaling pathway (GO:0060333)3.47858015
44detection of other organism (GO:0098543)3.46894441
45regulation of alpha-beta T cell proliferation (GO:0046640)3.43451160
46tolerance induction (GO:0002507)3.39878563
47antigen processing and presentation via MHC class Ib (GO:0002475)3.37788427
48regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.30187683
49Arp2/3 complex-mediated actin nucleation (GO:0034314)3.29388021
50regulation of cellular extravasation (GO:0002691)3.29203746
51negative regulation of leukocyte mediated immunity (GO:0002704)3.28673374
52regulation of cell killing (GO:0031341)3.26253218
53positive regulation of cell killing (GO:0031343)3.24878084
54positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.17017029
55neutrophil activation involved in immune response (GO:0002283)3.16845303
56NIK/NF-kappaB signaling (GO:0038061)3.14552989
57B cell mediated immunity (GO:0019724)3.14400777
58regulation of antigen processing and presentation (GO:0002577)3.12092024
59regulation of dendritic cell antigen processing and presentation (GO:0002604)3.10448013
60T cell receptor signaling pathway (GO:0050852)3.09078565
61positive regulation of antigen processing and presentation (GO:0002579)3.08013015
62positive regulation of natural killer cell mediated immunity (GO:0002717)3.05835608
63T cell costimulation (GO:0031295)3.05038942
64regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.04879915
65lymphocyte costimulation (GO:0031294)3.02603448
66negative regulation of viral genome replication (GO:0045071)3.01172865
67dendritic cell chemotaxis (GO:0002407)2.99227378
68positive regulation of B cell differentiation (GO:0045579)2.98284438
69lymphocyte chemotaxis (GO:0048247)2.93348771
70antigen receptor-mediated signaling pathway (GO:0050851)2.91958682
71actin nucleation (GO:0045010)2.88945684
72positive regulation of alpha-beta T cell proliferation (GO:0046641)2.87483033
73negative regulation of innate immune response (GO:0045824)2.86787935
74negative regulation of T cell mediated immunity (GO:0002710)2.85815102
75positive regulation of T cell mediated immunity (GO:0002711)2.83813803
76regulation of T cell mediated immunity (GO:0002709)2.83375702
77regulation of B cell differentiation (GO:0045577)2.81272135
78cellular response to interferon-beta (GO:0035458)2.81005733
79lymphocyte migration (GO:0072676)2.80521769
80regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.77179341
81cellular response to interferon-gamma (GO:0071346)2.76360561
82DNA deamination (GO:0045006)2.76264297
83positive regulation of calcium-mediated signaling (GO:0050850)2.75846120
84neutrophil activation (GO:0042119)2.75036554
85activated T cell proliferation (GO:0050798)2.70737041
86dendritic cell migration (GO:0036336)2.67867833
87positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.67528153
88regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.66642092
89cellular defense response (GO:0006968)2.66069127
90response to interferon-gamma (GO:0034341)2.65213799
91detection of external biotic stimulus (GO:0098581)2.64000914
92negative regulation of T cell apoptotic process (GO:0070233)2.62112205
93positive regulation of defense response to virus by host (GO:0002230)2.61779702
94mast cell activation (GO:0045576)2.61446266
95macrophage activation involved in immune response (GO:0002281)2.59062598
96positive regulation of lymphocyte mediated immunity (GO:0002708)2.58480318
97chemokine-mediated signaling pathway (GO:0070098)2.58212865
98negative regulation of interleukin-12 production (GO:0032695)2.58162583
99B cell receptor signaling pathway (GO:0050853)2.57826014
100regulation of isotype switching to IgG isotypes (GO:0048302)2.57703481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.66832969
2* IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.20353512
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.30137818
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.26841589
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.74908188
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.62639638
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.17183194
8RUNX_20019798_ChIP-Seq_JUKART_Human2.85458895
9MYB_26560356_Chip-Seq_TH2_Human2.63267237
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.55833063
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52364533
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50978952
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.46425597
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.46270169
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.35067197
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.20787016
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.20572251
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13081281
19MAF_26560356_Chip-Seq_TH1_Human2.09087860
20MYB_26560356_Chip-Seq_TH1_Human2.01992185
21* UTX_26944678_Chip-Seq_JUKART_Human2.00662737
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97283119
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90861163
24SPI1_23547873_ChIP-Seq_NB4_Human1.84950349
25GATA3_27048872_Chip-Seq_THYMUS_Human1.84624470
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.84059480
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82924240
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.72880915
29SPI1_23127762_ChIP-Seq_K562_Human1.71197109
30VDR_24763502_ChIP-Seq_THP-1_Human1.68028930
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.67431553
32LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63289666
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60365925
34SCL_19346495_ChIP-Seq_HPC-7_Human1.59312663
35GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.59167018
36* GATA3_26560356_Chip-Seq_TH2_Human1.58240082
37MAF_26560356_Chip-Seq_TH2_Human1.51270174
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50253663
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49807671
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48742830
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47270981
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.46649472
43BCL6_27268052_Chip-Seq_Bcells_Human1.43315952
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35464222
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33928385
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31095535
47CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29521451
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25834503
49VDR_21846776_ChIP-Seq_THP-1_Human1.24313707
50BCOR_27268052_Chip-Seq_Bcells_Human1.22583315
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18801629
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16262140
53STAT1_20625510_ChIP-Seq_HELA_Human1.15778104
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.15380257
55LXR_22292898_ChIP-Seq_THP-1_Human1.14759581
56ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14278059
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.12949189
58GATA1_19941826_ChIP-Seq_K562_Human1.12810604
59RXR_22158963_ChIP-Seq_LIVER_Mouse1.12695803
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12410178
61VDR_24787735_ChIP-Seq_THP-1_Human1.12141463
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11191888
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09992111
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05768182
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.04519734
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03792423
67PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02765215
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02479406
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01738195
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00724774
71* P300_27268052_Chip-Seq_Bcells_Human0.99937010
72P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99912686
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99713452
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99003635
75SA1_27219007_Chip-Seq_Bcells_Human0.97605337
76GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93721721
77ELK3_25401928_ChIP-Seq_HUVEC_Human0.92622277
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92519641
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92211813
80TCF7_22412390_ChIP-Seq_EML_Mouse0.91437417
81PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89719457
82PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89579446
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88815358
84GATA2_19941826_ChIP-Seq_K562_Human0.87656368
85YY1_22570637_ChIP-Seq_MALME-3M_Human0.85690797
86RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83806195
87RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.83673872
88* SOX2_20726797_ChIP-Seq_SW620_Human0.83275783
89KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82560708
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81600310
91SPI1_20517297_ChIP-Seq_HL60_Human0.80956305
92TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80938956
93BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.80514249
94SA1_27219007_Chip-Seq_ERYTHROID_Human0.80469653
95CTCF_20526341_ChIP-Seq_ESCs_Human0.80380819
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79876272
97E2F1_20622854_ChIP-Seq_HELA_Human0.79526346
98NANOG_20526341_ChIP-Seq_ESCs_Human0.79263873
99* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79003259
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78919763

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.26637514
2MP0001835_abnormal_antigen_presentation3.86528284
3MP0003724_increased_susceptibility_to3.63952621
4MP0003436_decreased_susceptibility_to3.42088674
5MP0009785_altered_susceptibility_to3.14366437
6MP0006082_CNS_inflammation3.14143919
7MP0003763_abnormal_thymus_physiology3.05865034
8MP0005025_abnormal_response_to2.94108815
9MP0005000_abnormal_immune_tolerance2.90403760
10MP0001790_abnormal_immune_system2.84097076
11MP0005387_immune_system_phenotype2.84097076
12MP0001800_abnormal_humoral_immune2.81401738
13MP0000685_abnormal_immune_system2.76303852
14MP0010155_abnormal_intestine_physiology2.68613149
15MP0002148_abnormal_hypersensitivity_rea2.55473872
16MP0002723_abnormal_immune_serum2.52804200
17MP0002419_abnormal_innate_immunity2.45897077
18MP0002420_abnormal_adaptive_immunity2.44336747
19MP0001819_abnormal_immune_cell2.42288926
20MP0002452_abnormal_antigen_presenting2.39457937
21MP0009333_abnormal_splenocyte_physiolog2.33483680
22MP0003866_abnormal_defecation2.24703882
23MP0002166_altered_tumor_susceptibility2.12561033
24MP0005360_urolithiasis2.11222088
25MP0001845_abnormal_inflammatory_respons1.98629442
26MP0005464_abnormal_platelet_physiology1.98024760
27MP0004947_skin_inflammation1.96736131
28MP0001533_abnormal_skeleton_physiology1.88972741
29MP0003303_peritoneal_inflammation1.84563550
30MP0001873_stomach_inflammation1.82845516
31MP0000716_abnormal_immune_system1.82451525
32MP0002405_respiratory_system_inflammati1.78131425
33MP0002398_abnormal_bone_marrow1.73855286
34MP0008469_abnormal_protein_level1.64373845
35MP0003300_gastrointestinal_ulcer1.58441008
36MP0005166_decreased_susceptibility_to1.56478669
37MP0000465_gastrointestinal_hemorrhage1.55360187
38MP0002132_abnormal_respiratory_system1.49679552
39MP0002006_tumorigenesis1.48635558
40MP0003806_abnormal_nucleotide_metabolis1.48470020
41MP0000689_abnormal_spleen_morphology1.43992608
42MP0000858_altered_metastatic_potential1.43328428
43MP0002722_abnormal_immune_system1.43282271
44MP0009764_decreased_sensitivity_to1.42725680
45MP0003191_abnormal_cellular_cholesterol1.41581531
46MP0002429_abnormal_blood_cell1.39890229
47MP0002933_joint_inflammation1.36538221
48MP0003183_abnormal_peptide_metabolism1.35613100
49MP0000703_abnormal_thymus_morphology1.34858390
50MP0009840_abnormal_foam_cell1.32172323
51MP0002277_abnormal_respiratory_mucosa1.27958192
52MP0008875_abnormal_xenobiotic_pharmacok1.26420726
53MP0003075_altered_response_to1.26081388
54MP0005085_abnormal_gallbladder_physiolo1.25787585
55MP0002139_abnormal_hepatobiliary_system1.24079928
56MP0005310_abnormal_salivary_gland1.23628364
57MP0003045_fibrosis1.20213635
58MP0003448_altered_tumor_morphology1.18773982
59MP0009763_increased_sensitivity_to1.10759071
60MP0002138_abnormal_hepatobiliary_system1.07471106
61MP0001851_eye_inflammation1.06964924
62MP0005365_abnormal_bile_salt1.05343062
63MP0002998_abnormal_bone_remodeling1.04713824
64MP0001853_heart_inflammation0.99632850
65MP0009643_abnormal_urine_homeostasis0.98150525
66MP0001765_abnormal_ion_homeostasis0.96183754
67MP0001663_abnormal_digestive_system0.95374659
68MP0005164_abnormal_response_to0.93883500
69MP0001666_abnormal_nutrient_absorption0.91724524
70MP0005083_abnormal_biliary_tract0.88398517
71MP0004019_abnormal_vitamin_homeostasis0.87893686
72MP0008260_abnormal_autophagy0.87025248
73MP0004883_abnormal_blood_vessel0.86944674
74MP0000604_amyloidosis0.85697512
75MP0002136_abnormal_kidney_physiology0.85427361
76MP0001986_abnormal_taste_sensitivity0.84067432
77MP0000490_abnormal_crypts_of0.82653998
78MP0000249_abnormal_blood_vessel0.82462135
79MP0005165_increased_susceptibility_to0.81442519
80MP0005390_skeleton_phenotype0.81279718
81MP0002876_abnormal_thyroid_physiology0.80173433
82MP0002396_abnormal_hematopoietic_system0.75838220
83MP0003252_abnormal_bile_duct0.75774372
84MP0000343_altered_response_to0.74350016
85MP0004510_myositis0.72191323
86MP0004264_abnormal_extraembryonic_tissu0.70363982
87MP0009765_abnormal_xenobiotic_induced0.68609847
88MP0010329_abnormal_lipoprotein_level0.68186187
89MP0005584_abnormal_enzyme/coenzyme_acti0.67535331
90MP0005058_abnormal_lysosome_morphology0.66044929
91MP0005319_abnormal_enzyme/_coenzyme0.65980230
92MP0003690_abnormal_glial_cell0.65133253
93MP0005075_abnormal_melanosome_morpholog0.64644744
94MP0005636_abnormal_mineral_homeostasis0.64528391
95MP0004381_abnormal_hair_follicle0.63870099
96MP0008004_abnormal_stomach_pH0.62514442
97MP0008874_decreased_physiological_sensi0.62278518
98MP0003795_abnormal_bone_structure0.61582563
99MP0002693_abnormal_pancreas_physiology0.61071878
100MP0003172_abnormal_lysosome_physiology0.60976838

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.44444841
2Eczematoid dermatitis (HP:0000976)4.64213174
3Myositis (HP:0100614)4.32280633
4Abnormality of T cell number (HP:0011839)4.30341947
5T lymphocytopenia (HP:0005403)4.14796748
6Abnormal delayed hypersensitivity skin test (HP:0002963)4.03327232
7Abnormality of macrophages (HP:0004311)3.91121979
8Recurrent abscess formation (HP:0002722)3.88867544
9Autoimmune hemolytic anemia (HP:0001890)3.83037899
10Increased IgM level (HP:0003496)3.81149939
11Recurrent bacterial skin infections (HP:0005406)3.71157147
12Nasal polyposis (HP:0100582)3.60740921
13Orchitis (HP:0100796)3.60530166
14Encephalitis (HP:0002383)3.49716035
15Abnormality of T cells (HP:0002843)3.48739351
16Recurrent bronchitis (HP:0002837)3.44027612
17Stomatitis (HP:0010280)3.40578519
18Systemic lupus erythematosus (HP:0002725)3.39949636
19Retrobulbar optic neuritis (HP:0100654)3.37901247
20Optic neuritis (HP:0100653)3.37901247
21Meningitis (HP:0001287)3.32164982
22Recurrent fungal infections (HP:0002841)3.27075235
23Chronic diarrhea (HP:0002028)3.26627012
24Abnormality of the nasal mucosa (HP:0000433)3.22696039
25Vasculitis (HP:0002633)3.22043066
26Pustule (HP:0200039)3.19549646
27Recurrent gram-negative bacterial infections (HP:0005420)3.18362532
28Gastrointestinal infarctions (HP:0005244)3.18160072
29IgG deficiency (HP:0004315)3.13963145
30Hypergammaglobulinemia (HP:0010702)2.95796104
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.95166461
32Chronic otitis media (HP:0000389)2.93185549
33Eosinophilia (HP:0001880)2.92724235
34Obstructive lung disease (HP:0006536)2.91861711
35Chronic obstructive pulmonary disease (HP:0006510)2.91861711
36Granulocytopenia (HP:0001913)2.91218510
37Recurrent cutaneous fungal infections (HP:0011370)2.91030417
38Chronic mucocutaneous candidiasis (HP:0002728)2.91030417
39Spontaneous hematomas (HP:0007420)2.89409613
40Leukocytosis (HP:0001974)2.89011787
41Pulmonary infiltrates (HP:0002113)2.88702515
42Abnormality of T cell physiology (HP:0011840)2.85847892
43Recurrent skin infections (HP:0001581)2.85711765
44Autoimmune thrombocytopenia (HP:0001973)2.85205945
45Mediastinal lymphadenopathy (HP:0100721)2.84164997
46Bronchiectasis (HP:0002110)2.83915834
47Bronchitis (HP:0012387)2.82243277
48Abnormality of eosinophils (HP:0001879)2.79773596
49Panhypogammaglobulinemia (HP:0003139)2.74737172
50Severe combined immunodeficiency (HP:0004430)2.73689269
51Agammaglobulinemia (HP:0004432)2.72669457
52Increased IgE level (HP:0003212)2.70053246
53Abnormal respiratory motile cilium morphology (HP:0005938)2.69456781
54Abnormal respiratory epithelium morphology (HP:0012253)2.69456781
55Purpura (HP:0000979)2.68257974
56Dynein arm defect of respiratory motile cilia (HP:0012255)2.67589571
57Absent/shortened dynein arms (HP:0200106)2.67589571
58Recurrent sinusitis (HP:0011108)2.66130577
59Malnutrition (HP:0004395)2.60735598
60Chronic sinusitis (HP:0011109)2.60571095
61Recurrent viral infections (HP:0004429)2.59425508
62Petechiae (HP:0000967)2.57361233
63Abnormal respiratory motile cilium physiology (HP:0012261)2.56768429
64Inflammation of the large intestine (HP:0002037)2.55878991
65Hemoptysis (HP:0002105)2.51716479
66Abnormal ciliary motility (HP:0012262)2.50523353
67Urticaria (HP:0001025)2.48537177
68Keratoconjunctivitis sicca (HP:0001097)2.47312102
69Joint swelling (HP:0001386)2.40589711
70Chest pain (HP:0100749)2.40038555
71Gastrointestinal inflammation (HP:0004386)2.39701267
72IgM deficiency (HP:0002850)2.38657251
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.37791575
74Pulmonary embolism (HP:0002204)2.37134791
75Keratoconjunctivitis (HP:0001096)2.35604893
76Gingivitis (HP:0000230)2.35597532
77Lymphopenia (HP:0001888)2.32203002
78Epistaxis (HP:0000421)2.29398363
79Rhinitis (HP:0012384)2.26722871
80Gingival bleeding (HP:0000225)2.25243550
81Prolonged bleeding time (HP:0003010)2.24502676
82Colitis (HP:0002583)2.24484974
83Recurrent otitis media (HP:0000403)2.22337513
84Abnormality of B cell number (HP:0010975)2.22101175
85Abnormality of glutamine family amino acid metabolism (HP:0010902)2.21398229
86Hypoproteinemia (HP:0003075)2.19914344
87Anorexia (HP:0002039)2.17134764
88Skin rash (HP:0000988)2.09488475
89Combined immunodeficiency (HP:0005387)2.09253127
90Gangrene (HP:0100758)2.08176879
91Alveolar cell carcinoma (HP:0006519)2.07685572
92Hypochromic anemia (HP:0001931)2.06854961
93Arterial thrombosis (HP:0004420)2.01240233
94Abnormality of the pleura (HP:0002103)1.99227905
95Thyroiditis (HP:0100646)1.98053385
96Increased serum ferritin (HP:0003281)1.97230968
97Chronic bronchitis (HP:0004469)1.92375154
98Abnormality of the prostate (HP:0008775)1.92059124
99Acute hepatic failure (HP:0006554)1.90045369
100Complement deficiency (HP:0004431)1.89463419

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.13836434
2TXK3.99158313
3TESK22.97584858
4RIPK42.69658026
5ERN12.69598040
6TYK22.59975850
7GRK62.56522627
8TAOK32.53801949
9KDR2.51931786
10ZAP702.50820800
11FES2.37848634
12CSK2.20726569
13IKBKE2.15719249
14TBK12.10307570
15TNK22.01518761
16JAK31.91373519
17ITK1.85362888
18BTK1.84789037
19JAK11.82118366
20IRAK41.78205835
21SYK1.71816381
22EPHB11.71696691
23BLK1.69769746
24MAP3K31.63469172
25MAP3K111.57853740
26KIT1.53013158
27LCK1.49098074
28TLK11.45979916
29MST41.44244946
30TESK11.43323469
31STK101.38212259
32MAP3K141.33079985
33MAP2K31.32910868
34IKBKB1.31040244
35LYN1.26802835
36CSF1R1.26067120
37MARK31.25265729
38TEC1.24984078
39HCK1.22166813
40FGFR41.17603939
41MST1R1.12381614
42PRKCQ1.11583502
43BMPR21.10697854
44EPHA21.06815456
45EPHA31.03758810
46GRK71.00247273
47MAPK150.95869156
48JAK20.86461661
49MAP3K120.85417843
50NLK0.79425824
51MAP2K60.79003119
52PIM10.78794821
53MAP3K130.78035897
54PRPF4B0.77431282
55LRRK20.75318721
56HIPK20.75015287
57FGFR30.74219401
58ACVR1B0.73926343
59MAP3K10.73374857
60SIK30.72736389
61FGR0.68338918
62ADRBK20.68327517
63CAMKK20.64297095
64PTK2B0.64254395
65FYN0.63164621
66MATK0.61179608
67MAP2K20.59482768
68TGFBR20.58055859
69PIK3CG0.57316635
70PTK60.56123622
71MAP3K20.55963451
72PDK10.54373571
73PIK3CA0.52471633
74PRKG20.52346658
75IRAK10.52158844
76MYLK0.51899882
77TAOK10.49227331
78BCKDK0.48907915
79MAPK110.48720486
80TAOK20.45152305
81MAPKAPK30.44346902
82RIPK10.43047265
83PRKCD0.42668453
84GRK50.42127337
85MAPKAPK20.41974558
86IGF1R0.39328557
87CDK190.37651703
88MAPK70.35864602
89CAMKK10.35818961
90CDC42BPA0.35040264
91ABL10.32984997
92SCYL20.32963730
93PDPK10.32078544
94DAPK10.30566760
95TRPM70.29881368
96LIMK10.27809774
97SRC0.27249989
98MAP3K50.26720128
99INSR0.25309392
100LMTK20.24634878

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.03222342
2Allograft rejection_Homo sapiens_hsa053303.83860622
3Primary immunodeficiency_Homo sapiens_hsa053403.71838854
4Autoimmune thyroid disease_Homo sapiens_hsa053203.66693187
5Antigen processing and presentation_Homo sapiens_hsa046123.00855505
6Type I diabetes mellitus_Homo sapiens_hsa049402.90992271
7Staphylococcus aureus infection_Homo sapiens_hsa051502.67554924
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.67249088
9Asthma_Homo sapiens_hsa053102.61956263
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.37220843
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.32269667
12Leishmaniasis_Homo sapiens_hsa051402.30738699
13Hematopoietic cell lineage_Homo sapiens_hsa046402.10767417
14Viral myocarditis_Homo sapiens_hsa054161.96373547
15T cell receptor signaling pathway_Homo sapiens_hsa046601.73534833
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.65634728
17Measles_Homo sapiens_hsa051621.60724311
18Osteoclast differentiation_Homo sapiens_hsa043801.59991623
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56399355
20Caffeine metabolism_Homo sapiens_hsa002321.49505217
21Rheumatoid arthritis_Homo sapiens_hsa053231.42634339
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37902948
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32943172
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.31952055
25Toxoplasmosis_Homo sapiens_hsa051451.27293825
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.26544538
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26308263
28Tuberculosis_Homo sapiens_hsa051521.26308078
29Herpes simplex infection_Homo sapiens_hsa051681.23843567
30Pertussis_Homo sapiens_hsa051331.21481789
31Malaria_Homo sapiens_hsa051441.20207081
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15465238
33Influenza A_Homo sapiens_hsa051641.13737396
34Chemokine signaling pathway_Homo sapiens_hsa040621.13174783
35Chemical carcinogenesis_Homo sapiens_hsa052041.12008914
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11978082
37B cell receptor signaling pathway_Homo sapiens_hsa046621.10179594
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08379440
39Linoleic acid metabolism_Homo sapiens_hsa005911.08254481
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07957525
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04157886
42TNF signaling pathway_Homo sapiens_hsa046681.03574369
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02604867
44Histidine metabolism_Homo sapiens_hsa003400.99264614
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.95298694
46African trypanosomiasis_Homo sapiens_hsa051430.93441386
47Arachidonic acid metabolism_Homo sapiens_hsa005900.92284759
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86334985
49Fat digestion and absorption_Homo sapiens_hsa049750.86274364
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.83231517
51Retinol metabolism_Homo sapiens_hsa008300.82320825
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.82284413
53Shigellosis_Homo sapiens_hsa051310.80816341
54Hepatitis C_Homo sapiens_hsa051600.80434504
55Phagosome_Homo sapiens_hsa041450.79680176
56Other glycan degradation_Homo sapiens_hsa005110.78948490
57Legionellosis_Homo sapiens_hsa051340.78425353
58Salmonella infection_Homo sapiens_hsa051320.71311060
59Complement and coagulation cascades_Homo sapiens_hsa046100.69955499
60Apoptosis_Homo sapiens_hsa042100.64257565
61Sulfur metabolism_Homo sapiens_hsa009200.61939696
62Renin-angiotensin system_Homo sapiens_hsa046140.61769002
63Vitamin digestion and absorption_Homo sapiens_hsa049770.58791413
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57790043
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.57779146
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56657281
67Mineral absorption_Homo sapiens_hsa049780.55824606
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55639743
69Platelet activation_Homo sapiens_hsa046110.54018688
70Phenylalanine metabolism_Homo sapiens_hsa003600.49244431
71Acute myeloid leukemia_Homo sapiens_hsa052210.48086968
72Lysosome_Homo sapiens_hsa041420.47939962
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44960779
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43416579
75Starch and sucrose metabolism_Homo sapiens_hsa005000.42495791
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39390384
77Proteasome_Homo sapiens_hsa030500.39242758
78Epstein-Barr virus infection_Homo sapiens_hsa051690.37381013
79Endocytosis_Homo sapiens_hsa041440.36534510
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36320825
81Glycerolipid metabolism_Homo sapiens_hsa005610.36189001
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36124768
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35730341
84Systemic lupus erythematosus_Homo sapiens_hsa053220.35663669
85Peroxisome_Homo sapiens_hsa041460.34376158
86Hepatitis B_Homo sapiens_hsa051610.33111513
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32207736
88Regulation of autophagy_Homo sapiens_hsa041400.32128185
89PPAR signaling pathway_Homo sapiens_hsa033200.31794780
90ABC transporters_Homo sapiens_hsa020100.31295933
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.30506570
92Fructose and mannose metabolism_Homo sapiens_hsa000510.29680230
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.29574725
94Tyrosine metabolism_Homo sapiens_hsa003500.28651323
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.28276405
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.26981891
97Galactose metabolism_Homo sapiens_hsa000520.24165765
98HTLV-I infection_Homo sapiens_hsa051660.24089193
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23709013
100Glutathione metabolism_Homo sapiens_hsa004800.23065899

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