RARS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This nuclear gene encodes a protein that localizes to the mitochondria, where it catalyzes the transfer of L-arginine to its cognate tRNA, an important step in translation of mitochondrially-encoded proteins. Defects in this gene are a cause of pontocerebellar hypoplasia type 6 (PCH6). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.24472207
2ribosomal small subunit assembly (GO:0000028)4.84584240
3proteasome assembly (GO:0043248)4.54914815
4nucleobase biosynthetic process (GO:0046112)4.51454966
5DNA strand elongation involved in DNA replication (GO:0006271)4.34589250
6telomere maintenance via semi-conservative replication (GO:0032201)4.31984000
7purine nucleobase biosynthetic process (GO:0009113)4.21304375
8DNA strand elongation (GO:0022616)4.20258302
9ribosomal large subunit biogenesis (GO:0042273)4.14638052
10formation of translation preinitiation complex (GO:0001731)4.08690546
11DNA double-strand break processing (GO:0000729)4.05930300
12telomere maintenance via recombination (GO:0000722)3.95648986
13deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.86993094
14protein neddylation (GO:0045116)3.85336368
15DNA replication initiation (GO:0006270)3.77315984
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.76540608
17IMP biosynthetic process (GO:0006188)3.73300099
18mitotic recombination (GO:0006312)3.70086186
19respiratory chain complex IV assembly (GO:0008535)3.69088524
20CENP-A containing nucleosome assembly (GO:0034080)3.67871493
21positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.62862346
22maturation of SSU-rRNA (GO:0030490)3.62516745
23chromatin remodeling at centromere (GO:0031055)3.60981952
24regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.60153605
25DNA replication checkpoint (GO:0000076)3.57443246
26rRNA modification (GO:0000154)3.54851731
27viral mRNA export from host cell nucleus (GO:0046784)3.54598693
28anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.53259280
29ribonucleoprotein complex biogenesis (GO:0022613)3.50258933
30telomere maintenance via telomere lengthening (GO:0010833)3.49298205
31DNA unwinding involved in DNA replication (GO:0006268)3.47616283
32establishment of integrated proviral latency (GO:0075713)3.46496851
33replication fork processing (GO:0031297)3.45347416
34ribosome biogenesis (GO:0042254)3.44918648
35regulation of cellular amino acid metabolic process (GO:0006521)3.43137332
36DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.42730804
37ribosome assembly (GO:0042255)3.41602315
38intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.40733478
39signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.40733478
40signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.39432969
41signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.39432969
42signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.39432969
43SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.38857887
44pseudouridine synthesis (GO:0001522)3.37702953
45negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.35731455
46negative regulation of ligase activity (GO:0051352)3.35731455
47cullin deneddylation (GO:0010388)3.34298855
48negative regulation of DNA-dependent DNA replication (GO:2000104)3.31618148
49signal transduction involved in DNA integrity checkpoint (GO:0072401)3.31359153
50signal transduction involved in DNA damage checkpoint (GO:0072422)3.31359153
51cotranslational protein targeting to membrane (GO:0006613)3.30199528
52viral transcription (GO:0019083)3.29274224
53protein deneddylation (GO:0000338)3.28630953
54protein-cofactor linkage (GO:0018065)3.28514042
55translational termination (GO:0006415)3.28468749
56maturation of 5.8S rRNA (GO:0000460)3.27871702
57signal transduction involved in cell cycle checkpoint (GO:0072395)3.26951849
58oxidative phosphorylation (GO:0006119)3.26936711
59protein targeting to ER (GO:0045047)3.25609884
60translational elongation (GO:0006414)3.22111120
61spliceosomal snRNP assembly (GO:0000387)3.22102482
62water-soluble vitamin biosynthetic process (GO:0042364)3.21889422
63transcription-coupled nucleotide-excision repair (GO:0006283)3.21084920
64nucleotide-excision repair, DNA gap filling (GO:0006297)3.20397420
65ribosomal small subunit biogenesis (GO:0042274)3.20294893
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.19817847
677-methylguanosine mRNA capping (GO:0006370)3.19038959
68protein localization to endoplasmic reticulum (GO:0070972)3.16485591
69DNA replication-independent nucleosome organization (GO:0034724)3.15926003
70DNA replication-independent nucleosome assembly (GO:0006336)3.15926003
71IMP metabolic process (GO:0046040)3.14057219
72regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.13911754
73regulation of mitotic spindle checkpoint (GO:1903504)3.13911754
74rRNA processing (GO:0006364)3.13033454
75mitotic metaphase plate congression (GO:0007080)3.12042238
76RNA capping (GO:0036260)3.11298745
777-methylguanosine RNA capping (GO:0009452)3.11298745
78establishment of protein localization to mitochondrial membrane (GO:0090151)3.11273406
79kinetochore organization (GO:0051383)3.10786925
80translation (GO:0006412)3.10676780
81resolution of meiotic recombination intermediates (GO:0000712)3.10672239
82DNA damage response, detection of DNA damage (GO:0042769)3.10088767
83rRNA methylation (GO:0031167)3.09994052
84protein localization to kinetochore (GO:0034501)3.07682904
85protein complex biogenesis (GO:0070271)3.07321562
86positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.06767040
87COPI coating of Golgi vesicle (GO:0048205)3.05135171
88Golgi transport vesicle coating (GO:0048200)3.05135171
89establishment of protein localization to endoplasmic reticulum (GO:0072599)3.04712607
90G1/S transition of mitotic cell cycle (GO:0000082)3.04678825
91cell cycle G1/S phase transition (GO:0044843)3.04678825
92cellular component biogenesis (GO:0044085)3.04141657
93translational initiation (GO:0006413)3.03782109
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03327637
95kinetochore assembly (GO:0051382)3.02732895
96mitochondrial respiratory chain complex assembly (GO:0033108)3.01904059
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00883314
98rRNA metabolic process (GO:0016072)3.00737219
99cytochrome complex assembly (GO:0017004)3.00481992
100regulation of DNA endoreduplication (GO:0032875)3.00137678
101termination of RNA polymerase I transcription (GO:0006363)2.99262243
102folic acid-containing compound biosynthetic process (GO:0009396)2.99030429
103metallo-sulfur cluster assembly (GO:0031163)2.98171284
104iron-sulfur cluster assembly (GO:0016226)2.98171284
105histone exchange (GO:0043486)2.97899104
106antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.95288828
107lactate metabolic process (GO:0006089)2.94978750
108intraciliary transport (GO:0042073)2.94302982
109pyrimidine nucleobase catabolic process (GO:0006208)2.94192161
110positive regulation of ligase activity (GO:0051351)2.92684471
111telomere organization (GO:0032200)2.90235696
112telomere maintenance (GO:0000723)2.89586934
113RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.89358085
114tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.89358085
115mitochondrial respiratory chain complex I assembly (GO:0032981)2.88257143
116NADH dehydrogenase complex assembly (GO:0010257)2.88257143
117mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.88257143
118transcription elongation from RNA polymerase I promoter (GO:0006362)2.87159514
119mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.86852535
120mitotic nuclear envelope disassembly (GO:0007077)2.86719995
121DNA replication-dependent nucleosome assembly (GO:0006335)2.86427496
122DNA replication-dependent nucleosome organization (GO:0034723)2.86427496
123regulation of helicase activity (GO:0051095)2.85615132
124somatic hypermutation of immunoglobulin genes (GO:0016446)2.84337817
125somatic diversification of immune receptors via somatic mutation (GO:0002566)2.84337817
126double-strand break repair via nonhomologous end joining (GO:0006303)2.83462899
127non-recombinational repair (GO:0000726)2.83462899
128tRNA methylation (GO:0030488)2.83357184
129pteridine-containing compound biosynthetic process (GO:0042559)2.83263558
130deoxyribose phosphate biosynthetic process (GO:0046385)2.83215195
131response to pheromone (GO:0019236)2.82712564
132L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81515912
133maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.71510998
134DNA ligation (GO:0006266)2.69929133
135DNA catabolic process, exonucleolytic (GO:0000738)2.67602473
136recombinational repair (GO:0000725)2.66213098
137branched-chain amino acid catabolic process (GO:0009083)2.65712265
138metaphase plate congression (GO:0051310)2.62766895
139double-strand break repair via homologous recombination (GO:0000724)2.62363191
140ATP synthesis coupled proton transport (GO:0015986)2.60524766
141energy coupled proton transport, down electrochemical gradient (GO:0015985)2.60524766
142positive regulation of mitochondrial fission (GO:0090141)2.58653639
143mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.56635262
144anterograde synaptic vesicle transport (GO:0048490)2.56061358
145negative regulation of DNA recombination (GO:0045910)2.55216920
146regulation of glucokinase activity (GO:0033131)2.54683276
147regulation of hexokinase activity (GO:1903299)2.54683276
148regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.54521412
149cholesterol biosynthetic process (GO:0006695)2.52883306
150histone mRNA metabolic process (GO:0008334)2.52579339
151histone H2A acetylation (GO:0043968)2.52305703
152RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.51509448
153spindle checkpoint (GO:0031577)2.51431791
154nucleobase catabolic process (GO:0046113)2.50390750
155regulation of nuclear cell cycle DNA replication (GO:0033262)2.45843394
156postreplication repair (GO:0006301)2.45221032
157presynaptic membrane assembly (GO:0097105)2.41891955
158mitotic spindle checkpoint (GO:0071174)2.41472995
159aldehyde catabolic process (GO:0046185)2.41436785
160mitochondrial RNA metabolic process (GO:0000959)2.41240107
161regulation of meiosis I (GO:0060631)2.40810629
162transcription elongation from RNA polymerase III promoter (GO:0006385)2.40494542
163termination of RNA polymerase III transcription (GO:0006386)2.40494542
164sterol biosynthetic process (GO:0016126)2.40310035
165cilium morphogenesis (GO:0060271)2.39630369
166organelle disassembly (GO:1903008)2.38896023
167somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.38384542
168somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.38384542
169isotype switching (GO:0045190)2.38384542
170regulation of acyl-CoA biosynthetic process (GO:0050812)2.37343431
171protein K11-linked ubiquitination (GO:0070979)2.36964704
172nonmotile primary cilium assembly (GO:0035058)2.35670487
173chaperone-mediated protein transport (GO:0072321)2.35320322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.97571100
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.53997993
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.29126649
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.75094746
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.67449388
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.66882881
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.60230533
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.27975098
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.20493534
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.19030615
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.12575199
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.10719662
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.06379547
14E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01285326
15SALL1_21062744_ChIP-ChIP_HESCs_Human3.00943001
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90050305
17ZNF274_21170338_ChIP-Seq_K562_Hela2.78311480
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77547162
19VDR_23849224_ChIP-Seq_CD4+_Human2.60427747
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.54217724
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.47255292
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45949757
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45252403
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.39348220
25FOXP3_21729870_ChIP-Seq_TREG_Human2.36900441
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36892817
27IGF1R_20145208_ChIP-Seq_DFB_Human2.34722844
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33520024
29EWS_26573619_Chip-Seq_HEK293_Human2.32638179
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.31854558
31FUS_26573619_Chip-Seq_HEK293_Human2.30551666
32* XRN2_22483619_ChIP-Seq_HELA_Human2.30543273
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27935448
34DCP1A_22483619_ChIP-Seq_HELA_Human2.21719562
35ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19099076
36FOXM1_23109430_ChIP-Seq_U2OS_Human2.15792754
37* GABP_19822575_ChIP-Seq_HepG2_Human2.15454827
38VDR_22108803_ChIP-Seq_LS180_Human2.11380733
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.10946364
40SRF_21415370_ChIP-Seq_HL-1_Mouse2.08699869
41FLI1_27457419_Chip-Seq_LIVER_Mouse2.07725261
42ELK1_19687146_ChIP-ChIP_HELA_Human2.07011931
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96794770
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94533019
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92714779
46* TTF2_22483619_ChIP-Seq_HELA_Human1.87290282
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85534346
48P300_19829295_ChIP-Seq_ESCs_Human1.83436265
49GBX2_23144817_ChIP-Seq_PC3_Human1.83342845
50CIITA_25753668_ChIP-Seq_RAJI_Human1.82714947
51* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80860217
52* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.80106893
53AR_21909140_ChIP-Seq_LNCAP_Human1.79921139
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79902736
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79590297
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79275441
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78392639
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76893789
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.75536418
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75264163
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.74924477
62TAF15_26573619_Chip-Seq_HEK293_Human1.72290674
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.70295025
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70005476
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67361676
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.63191900
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62709145
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59680204
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57387147
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54919800
71* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52172421
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50546761
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48031405
74* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46932618
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45316739
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44430503
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43795259
78KDM5A_27292631_Chip-Seq_BREAST_Human1.36742872
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35755750
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32897741
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32337108
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30864588
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30517707
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.30165143
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28580590
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28074086
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27958524
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26935922
89TFEB_21752829_ChIP-Seq_HELA_Human1.26709388
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23862486
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23277505
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.22223444
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21761571
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20120813
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19930614
96CBP_20019798_ChIP-Seq_JUKART_Human1.19930614
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17564269
98ER_23166858_ChIP-Seq_MCF-7_Human1.16758683
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.15759709
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15596590
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14982609
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.13403347
103NANOG_16153702_ChIP-ChIP_HESCs_Human1.13187994
104SMAD4_21799915_ChIP-Seq_A2780_Human1.12718356
105BCAT_22108803_ChIP-Seq_LS180_Human1.11871233
106* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11076721
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10969950
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09581980
109* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05842235
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04618119
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04569700
112GATA1_22025678_ChIP-Seq_K562_Human1.03673671
113CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03264959
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03155659
115POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02801156
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.02557158
117SOX2_19829295_ChIP-Seq_ESCs_Human1.01947742
118NANOG_19829295_ChIP-Seq_ESCs_Human1.01947742
119GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01782164
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.01018040
121MYC_18940864_ChIP-ChIP_HL60_Human1.00883795
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00883133
123TP53_22573176_ChIP-Seq_HFKS_Human1.00867542
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00605306
125NANOG_18555785_Chip-Seq_ESCs_Mouse1.00579865
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00281981
127ELK1_22589737_ChIP-Seq_MCF10A_Human0.99486240
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98797868
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98494874
130FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98075111
131SOX2_16153702_ChIP-ChIP_HESCs_Human0.97392856
132STAT3_23295773_ChIP-Seq_U87_Human0.94878332
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94466740
134TCF4_22108803_ChIP-Seq_LS180_Human0.93316952
135* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92958439
136DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92547344
137SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90899699
138MYC_22102868_ChIP-Seq_BL_Human0.90586104
139SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89891783
140CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89432661
141SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88701863
142HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88546744
143POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87480577
144KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86188246
145* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85370896
146* SPI1_23547873_ChIP-Seq_NB4_Human0.84102262
147CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83672417
148TP63_19390658_ChIP-ChIP_HaCaT_Human0.82018690
149CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81967486
150EGR1_19374776_ChIP-ChIP_THP-1_Human0.79830628
151KLF4_18555785_ChIP-Seq_MESCs_Mouse0.78418631
152IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.76837173
153SOX17_20123909_ChIP-Seq_XEN_Mouse0.75949320
154* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75810889
155TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75613904
156IRF8_22096565_ChIP-ChIP_GC-B_Human0.75042633
157IRF1_19129219_ChIP-ChIP_H3396_Human0.74727061
158* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73944684

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.03018628
2MP0010094_abnormal_chromosome_stability4.17746574
3MP0004957_abnormal_blastocyst_morpholog4.08580753
4MP0008058_abnormal_DNA_repair3.99281143
5MP0003111_abnormal_nucleus_morphology3.59828376
6MP0002102_abnormal_ear_morphology3.47713558
7MP0003077_abnormal_cell_cycle3.39793801
8MP0003123_paternal_imprinting3.09846607
9MP0003806_abnormal_nucleotide_metabolis3.01761854
10MP0008057_abnormal_DNA_replication2.97283386
11MP0008007_abnormal_cellular_replicative2.92001895
12MP0009697_abnormal_copulation2.57479919
13MP0008932_abnormal_embryonic_tissue2.44083034
14MP0001529_abnormal_vocalization2.35031188
15MP0003122_maternal_imprinting2.30828477
16MP0000372_irregular_coat_pigmentation2.21406433
17MP0003786_premature_aging2.21267984
18MP0001984_abnormal_olfaction2.14772536
19MP0008789_abnormal_olfactory_epithelium2.11119759
20MP0005075_abnormal_melanosome_morpholog2.09689015
21MP0003718_maternal_effect2.06043947
22MP0002396_abnormal_hematopoietic_system2.05093648
23MP0003763_abnormal_thymus_physiology1.93942142
24MP0001764_abnormal_homeostasis1.90438751
25MP0000490_abnormal_crypts_of1.89051815
26MP0003787_abnormal_imprinting1.85697084
27MP0006036_abnormal_mitochondrial_physio1.81049819
28MP0000516_abnormal_urinary_system1.74159185
29MP0005367_renal/urinary_system_phenotyp1.74159185
30MP0001730_embryonic_growth_arrest1.67871711
31MP0005499_abnormal_olfactory_system1.67614792
32MP0005394_taste/olfaction_phenotype1.67614792
33MP0001348_abnormal_lacrimal_gland1.66476472
34MP0005253_abnormal_eye_physiology1.65609078
35MP0003937_abnormal_limbs/digits/tail_de1.61562495
36MP0006292_abnormal_olfactory_placode1.61023441
37MP0003567_abnormal_fetal_cardiomyocyte1.59578224
38MP0002233_abnormal_nose_morphology1.58436201
39MP0005408_hypopigmentation1.58409083
40MP0000569_abnormal_digit_pigmentation1.57804587
41MP0004147_increased_porphyrin_level1.55473567
42MP0003186_abnormal_redox_activity1.53356375
43MP0002876_abnormal_thyroid_physiology1.52039520
44MP0003136_yellow_coat_color1.50223974
45MP0005551_abnormal_eye_electrophysiolog1.43534147
46MP0005084_abnormal_gallbladder_morpholo1.40582637
47MP0002736_abnormal_nociception_after1.39674837
48MP0003195_calcinosis1.39613566
49MP0002163_abnormal_gland_morphology1.39311048
50MP0000350_abnormal_cell_proliferation1.37914468
51MP0006276_abnormal_autonomic_nervous1.36668493
52MP0002877_abnormal_melanocyte_morpholog1.34531721
53MP0008877_abnormal_DNA_methylation1.32319879
54MP0000313_abnormal_cell_death1.27438131
55MP0003011_delayed_dark_adaptation1.25999219
56MP0002080_prenatal_lethality1.24998868
57MP0003941_abnormal_skin_development1.24820831
58MP0002090_abnormal_vision1.24450012
59MP0006054_spinal_hemorrhage1.23700955
60MP0001697_abnormal_embryo_size1.23434040
61MP0009333_abnormal_splenocyte_physiolog1.21805280
62MP0002938_white_spotting1.20399614
63MP0002638_abnormal_pupillary_reflex1.17448663
64MP0000049_abnormal_middle_ear1.17075828
65MP0002234_abnormal_pharynx_morphology1.16786982
66MP0002653_abnormal_ependyma_morphology1.15626521
67MP0002095_abnormal_skin_pigmentation1.15013187
68MP0002019_abnormal_tumor_incidence1.14298376
69MP0001286_abnormal_eye_development1.14227248
70MP0001293_anophthalmia1.13295434
71MP0002837_dystrophic_cardiac_calcinosis1.12589374
72MP0003755_abnormal_palate_morphology1.12429342
73MP0010030_abnormal_orbit_morphology1.10598280
74MP0004264_abnormal_extraembryonic_tissu1.09625880
75MP0003121_genomic_imprinting1.09349462
76MP0004215_abnormal_myocardial_fiber1.09167893
77MP0003315_abnormal_perineum_morphology1.07580657
78MP0006035_abnormal_mitochondrial_morpho1.05645668
79MP0001672_abnormal_embryogenesis/_devel1.05227629
80MP0005380_embryogenesis_phenotype1.05227629
81MP0003880_abnormal_central_pattern1.04695373
82MP0005220_abnormal_exocrine_pancreas1.04100825
83MP0003890_abnormal_embryonic-extraembry1.02940317
84MP0000647_abnormal_sebaceous_gland1.02782242
85MP0005389_reproductive_system_phenotype1.02107035
86MP0001986_abnormal_taste_sensitivity1.00644192
87MP0000631_abnormal_neuroendocrine_gland1.00603773
88MP0004142_abnormal_muscle_tone1.00158778
89MP0005391_vision/eye_phenotype0.99971795
90MP0002132_abnormal_respiratory_system0.99231741
91MP0005379_endocrine/exocrine_gland_phen0.99206206
92MP0005171_absent_coat_pigmentation0.98924577
93MP0001299_abnormal_eye_distance/0.98067710
94MP0001919_abnormal_reproductive_system0.97461750
95MP0000427_abnormal_hair_cycle0.96830802
96MP0004133_heterotaxia0.96767111
97MP0005187_abnormal_penis_morphology0.96265087
98MP0000778_abnormal_nervous_system0.95021909
99MP0001324_abnormal_eye_pigmentation0.94783462
100MP0008995_early_reproductive_senescence0.94681252
101MP0003984_embryonic_growth_retardation0.94679162
102MP0000358_abnormal_cell_content/0.94400797
103MP0003183_abnormal_peptide_metabolism0.93806746
104MP0002282_abnormal_trachea_morphology0.92262976
105MP0000678_abnormal_parathyroid_gland0.90733157
106MP0002210_abnormal_sex_determination0.90378030
107MP0002088_abnormal_embryonic_growth/wei0.89673237
108MP0000371_diluted_coat_color0.89428533
109MP0010352_gastrointestinal_tract_polyps0.89161238
110MP0002160_abnormal_reproductive_system0.88166288
111MP0001186_pigmentation_phenotype0.88143244
112MP0002085_abnormal_embryonic_tissue0.87907466
113MP0005266_abnormal_metabolism0.85999245
114MP0001177_atelectasis0.85001856
115MP0001485_abnormal_pinna_reflex0.84962298
116MP0001145_abnormal_male_reproductive0.83792167
117MP0003119_abnormal_digestive_system0.83572154
118MP0002751_abnormal_autonomic_nervous0.82938840
119MP0003646_muscle_fatigue0.81689397
120MP0000689_abnormal_spleen_morphology0.81572139
121MP0001119_abnormal_female_reproductive0.80719870
122MP0000703_abnormal_thymus_morphology0.80706082
123MP0000015_abnormal_ear_pigmentation0.80633015
124MP0000681_abnormal_thyroid_gland0.80564738
125MP0005195_abnormal_posterior_eye0.80481963
126MP0001873_stomach_inflammation0.80286821
127MP0003385_abnormal_body_wall0.77990731
128MP0002722_abnormal_immune_system0.76354462
129MP0000013_abnormal_adipose_tissue0.76313557
130MP0002075_abnormal_coat/hair_pigmentati0.75515018
131MP0001929_abnormal_gametogenesis0.75515018
132MP0002752_abnormal_somatic_nervous0.74643359
133MP0005645_abnormal_hypothalamus_physiol0.74050236
134MP0006072_abnormal_retinal_apoptosis0.72939173
135MP0002084_abnormal_developmental_patter0.71801533
136MP0003866_abnormal_defecation0.71609171
137MP0002557_abnormal_social/conspecific_i0.70718839
138MP0000653_abnormal_sex_gland0.70687710
139MP0004043_abnormal_pH_regulation0.70575181
140MP0003935_abnormal_craniofacial_develop0.70197267
141MP0001853_heart_inflammation0.69892446
142MP0002086_abnormal_extraembryonic_tissu0.69536809
143MP0004808_abnormal_hematopoietic_stem0.69105710
144MP0004782_abnormal_surfactant_physiolog0.68744123
145MP0002398_abnormal_bone_marrow0.68437921
146MP0001188_hyperpigmentation0.67507971
147MP0004197_abnormal_fetal_growth/weight/0.67311365
148MP0003943_abnormal_hepatobiliary_system0.66623331
149MP0003221_abnormal_cardiomyocyte_apopto0.66250031
150MP0005671_abnormal_response_to0.65504267
151MP0005397_hematopoietic_system_phenotyp0.63278559

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.00113851
2Birth length less than 3rd percentile (HP:0003561)3.98923778
3Selective tooth agenesis (HP:0001592)3.90007020
4Decreased activity of mitochondrial respiratory chain (HP:0008972)3.69628309
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.69628309
6Type I transferrin isoform profile (HP:0003642)3.51621324
7Abnormality of the labia minora (HP:0012880)3.45371304
8Abnormality of cells of the erythroid lineage (HP:0012130)3.39531161
9Reticulocytopenia (HP:0001896)3.28281567
10Microvesicular hepatic steatosis (HP:0001414)3.27661802
11Abnormal mitochondria in muscle tissue (HP:0008316)3.26817348
12Abnormal number of erythroid precursors (HP:0012131)3.24817696
13Hepatic necrosis (HP:0002605)3.21639612
14Generalized aminoaciduria (HP:0002909)3.14893154
15Acute necrotizing encephalopathy (HP:0006965)3.12421057
16Oral leukoplakia (HP:0002745)3.07330272
17Degeneration of anterior horn cells (HP:0002398)2.96324936
18Abnormality of the anterior horn cell (HP:0006802)2.96324936
19Rough bone trabeculation (HP:0100670)2.89019801
20Methylmalonic acidemia (HP:0002912)2.81127639
21Mitochondrial inheritance (HP:0001427)2.80904300
22* Increased serum lactate (HP:0002151)2.78789552
23Hepatocellular necrosis (HP:0001404)2.78213726
24Hyperglycinemia (HP:0002154)2.76002559
25Medial flaring of the eyebrow (HP:0010747)2.73385134
26* Increased CSF lactate (HP:0002490)2.71264302
2711 pairs of ribs (HP:0000878)2.67380779
28Acute encephalopathy (HP:0006846)2.65883737
29Microretrognathia (HP:0000308)2.63346357
30Hypoplastic pelvis (HP:0008839)2.61973911
31Carpal bone hypoplasia (HP:0001498)2.59374099
32Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.57828564
33Abnormal protein N-linked glycosylation (HP:0012347)2.57828564
34Abnormal protein glycosylation (HP:0012346)2.57828564
35Abnormal glycosylation (HP:0012345)2.57828564
36Molar tooth sign on MRI (HP:0002419)2.57134345
37Abnormality of midbrain morphology (HP:0002418)2.57134345
38Meckel diverticulum (HP:0002245)2.55056398
39Congenital primary aphakia (HP:0007707)2.53703378
40Gait imbalance (HP:0002141)2.45804827
41Abnormality of the ileum (HP:0001549)2.43359683
42Type 2 muscle fiber atrophy (HP:0003554)2.43118037
43Premature graying of hair (HP:0002216)2.41815166
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.41116005
45Lactic acidosis (HP:0003128)2.40128655
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.39952256
47Colon cancer (HP:0003003)2.38537016
48Genital tract atresia (HP:0001827)2.37929237
49Intestinal atresia (HP:0011100)2.37012308
50Nephrogenic diabetes insipidus (HP:0009806)2.36732610
51Macrocytic anemia (HP:0001972)2.35654323
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.34761843
53Irregular epiphyses (HP:0010582)2.34704738
54Hypoglycemic coma (HP:0001325)2.33921078
55Exercise intolerance (HP:0003546)2.33828255
56Lipid accumulation in hepatocytes (HP:0006561)2.33713737
57Neoplasm of the adrenal cortex (HP:0100641)2.31493818
58Breast hypoplasia (HP:0003187)2.30538676
59Renal cortical cysts (HP:0000803)2.30512783
60Bifid tongue (HP:0010297)2.29401354
61Vaginal atresia (HP:0000148)2.29147472
62Gonadotropin excess (HP:0000837)2.28763285
63Reduced antithrombin III activity (HP:0001976)2.27797325
64Progressive macrocephaly (HP:0004481)2.27469607
65Chromsome breakage (HP:0040012)2.25476313
66Increased serum pyruvate (HP:0003542)2.25343028
67Abnormality of glycolysis (HP:0004366)2.25343028
68Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24884226
69Nephronophthisis (HP:0000090)2.24580805
70Abnormality of methionine metabolism (HP:0010901)2.24015736
71Patellar aplasia (HP:0006443)2.21609452
72Pallor (HP:0000980)2.17972168
73Medulloblastoma (HP:0002885)2.17526682
74Abnormal trabecular bone morphology (HP:0100671)2.15739517
75Septo-optic dysplasia (HP:0100842)2.15431573
76Abnormal spermatogenesis (HP:0008669)2.15299217
77Increased hepatocellular lipid droplets (HP:0006565)2.15006697
78Renal Fanconi syndrome (HP:0001994)2.14694812
79Thrombocytosis (HP:0001894)2.14202491
80Neoplasm of the adrenal gland (HP:0100631)2.11812545
81Aplasia/Hypoplasia of the patella (HP:0006498)2.10666568
82Dicarboxylic aciduria (HP:0003215)2.09697535
83Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09697535
84Cellular immunodeficiency (HP:0005374)2.09066458
85Pancreatic fibrosis (HP:0100732)2.08639161
86Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08525142
87Muscle fiber atrophy (HP:0100295)2.07614571
88Abnormality of chromosome stability (HP:0003220)2.05735650
89IgM deficiency (HP:0002850)2.05729339
90Increased intramyocellular lipid droplets (HP:0012240)2.05111726
91Poikiloderma (HP:0001029)2.04490533
92Increased muscle lipid content (HP:0009058)2.03794085
93Short tibia (HP:0005736)2.03049544
94Nausea (HP:0002018)2.02669772
95Adrenal hypoplasia (HP:0000835)2.01954910
96Abnormal lung lobation (HP:0002101)2.01610227
97Methylmalonic aciduria (HP:0012120)2.01186672
98Abnormality of serum amino acid levels (HP:0003112)2.01049919
99Proximal tubulopathy (HP:0000114)2.00641056
100Facial cleft (HP:0002006)2.00372321
101Cerebral edema (HP:0002181)1.99611980
102Pancytopenia (HP:0001876)1.98433086
103Hypothermia (HP:0002045)1.97592102
104Ependymoma (HP:0002888)1.96533100
105Abnormality of the heme biosynthetic pathway (HP:0010472)1.95548173
106Abnormality of urine glucose concentration (HP:0011016)1.95491055
107Glycosuria (HP:0003076)1.95491055
108Abnormality of the renal cortex (HP:0011035)1.93903260
109Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92945691
110Aplasia/Hypoplasia of the tibia (HP:0005772)1.92641583
1113-Methylglutaconic aciduria (HP:0003535)1.92056977
112Pancreatic cysts (HP:0001737)1.91982046
113Aplasia/Hypoplasia of the tongue (HP:0010295)1.90279246
114Ragged-red muscle fibers (HP:0003200)1.89835313
115True hermaphroditism (HP:0010459)1.89194714
116Abnormal hair whorl (HP:0010721)1.88321069
117Optic nerve coloboma (HP:0000588)1.88122869
118Supernumerary spleens (HP:0009799)1.87080692
119Rhabdomyosarcoma (HP:0002859)1.85229591
120Lymphoma (HP:0002665)1.85198697
121Bone marrow hypocellularity (HP:0005528)1.84633240
122Poor coordination (HP:0002370)1.84457796
123Respiratory failure (HP:0002878)1.84318400
124Prominent metopic ridge (HP:0005487)1.84071870
125Abnormality of vitamin B metabolism (HP:0004340)1.83846417
126Glioma (HP:0009733)1.83421534
127Megaloblastic anemia (HP:0001889)1.83052710
128Abnormality of the metopic suture (HP:0005556)1.82429514
129Trismus (HP:0000211)1.82427845
130Nephroblastoma (Wilms tumor) (HP:0002667)1.81767780
131Cortical dysplasia (HP:0002539)1.80709734
132Optic disc pallor (HP:0000543)1.80351587
133Abolished electroretinogram (ERG) (HP:0000550)1.80170216
134Hepatoblastoma (HP:0002884)1.79961441
135Respiratory difficulties (HP:0002880)1.79703112
136Abnormality of the vitamin B12 metabolism (HP:0004341)1.79680181
137Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79550896
138Abnormality of alanine metabolism (HP:0010916)1.79550896
139Hyperalaninemia (HP:0003348)1.79550896
140Abnormality of the preputium (HP:0100587)1.79423348
141Pancreatic islet-cell hyperplasia (HP:0004510)1.78918993
142Hypoplasia of the radius (HP:0002984)1.78704424
143Astigmatism (HP:0000483)1.78637211
144Sloping forehead (HP:0000340)1.78401206
145Myelodysplasia (HP:0002863)1.78186522
146Bile duct proliferation (HP:0001408)1.77904172
147Abnormal biliary tract physiology (HP:0012439)1.77904172
148Abnormality of serine family amino acid metabolism (HP:0010894)1.77321498
149Abnormality of glycine metabolism (HP:0010895)1.77321498
150Abnormality of the renal medulla (HP:0100957)1.77226705
151Absent thumb (HP:0009777)1.76402880
152Optic nerve hypoplasia (HP:0000609)1.76205700
153Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.76106132
154Tubulointerstitial nephritis (HP:0001970)1.76006909
155Postaxial hand polydactyly (HP:0001162)1.75904745
156Sclerocornea (HP:0000647)1.71938768
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70825940
158Lethargy (HP:0001254)1.69520579
159Duodenal stenosis (HP:0100867)1.68592765
160Small intestinal stenosis (HP:0012848)1.68592765
161Stenosis of the external auditory canal (HP:0000402)1.67029547
162Volvulus (HP:0002580)1.65764144
163Dandy-Walker malformation (HP:0001305)1.65499785
164Abnormality of the duodenum (HP:0002246)1.64737132
165Decreased testicular size (HP:0008734)1.63948026
166Astrocytoma (HP:0009592)1.62228188
167Abnormality of the astrocytes (HP:0100707)1.62228188
168Postaxial foot polydactyly (HP:0001830)1.61200441

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.58042338
2WEE13.85946338
3BUB13.61671675
4EIF2AK33.54835582
5TRIM283.34010931
6STK163.16836585
7PASK2.86491877
8FRK2.78489811
9MAP4K22.77678167
10CDC72.76531484
11NEK12.69090353
12SRPK12.63289051
13BRSK22.61935359
14BCR2.40023049
15TSSK62.24662456
16NME22.17655481
17ACVR1B2.09847116
18FLT32.05719227
19MST41.98397028
20VRK11.88863675
21MKNK11.84556453
22BCKDK1.79284249
23BRSK11.77366071
24ZAK1.70515885
25PLK21.65780191
26NEK21.63268196
27PLK41.58858968
28MKNK21.53029507
29SCYL21.52297840
30MAP3K41.49567860
31TGFBR11.48563402
32ATR1.47476816
33TTK1.40396580
34CASK1.39070086
35PLK11.38869651
36CDK71.35275152
37PLK31.28879098
38AURKB1.27174341
39GRK11.26970662
40DYRK31.24735331
41RPS6KB21.24442181
42CSNK1G11.21517022
43MAPK131.17450107
44CSNK1G31.12093355
45CDK81.11376783
46EIF2AK21.10232610
47PAK31.08851985
48CSNK1G21.08342885
49MAPKAPK31.08234396
50RPS6KA41.07208529
51MAP3K121.01244235
52INSRR1.00049876
53AURKA0.98882188
54PDK30.97520103
55PDK40.97520103
56ERBB30.95693525
57CCNB10.94519695
58STK100.94397911
59PNCK0.91980813
60CSNK1A1L0.91111076
61EPHA20.90865729
62FGFR20.89318437
63ADRBK20.89314551
64VRK20.89223516
65AKT30.87066502
66STK390.84530085
67TIE10.82999516
68PINK10.82227687
69TLK10.82160691
70NUAK10.81621376
71STK30.81509410
72MAP3K30.81357121
73TAF10.80232535
74NME10.78886821
75PRKCE0.77620014
76MINK10.76498399
77MUSK0.73884865
78TEC0.73706889
79TAOK20.73661324
80MAP3K80.72688043
81CSNK2A10.72658501
82LATS10.72343818
83MARK10.71200255
84TNIK0.69651150
85CHEK20.68185256
86PAK40.67545448
87YES10.67517845
88PIM20.67235896
89MAP4K10.67166865
90PRKCG0.66775754
91BRAF0.66275964
92CHEK10.64519754
93IRAK40.60908985
94OXSR10.59997927
95CSNK2A20.59780666
96ATM0.58918753
97PIM10.58597302
98WNK40.58575921
99SIK30.58491913
100KDR0.57875654
101CDK40.56658273
102BTK0.56377616
103PRKCI0.55907026
104BMPR1B0.55311149
105TESK10.54948992
106CAMKK20.53999023
107KIT0.53546083
108WNK30.52519129
109CDK190.51364455
110TESK20.49371111
111TXK0.48531703
112DAPK10.47870823
113CDK20.47366220
114PBK0.47088819
115RPS6KB10.45151470
116ADRBK10.45136996
117PDK20.45098195
118OBSCN0.44350140
119STK38L0.43961665
120FGFR10.43428152
121DYRK1B0.42392733
122CSNK1E0.41844960
123IRAK30.41539363
124PIK3CA0.41459669
125MAP3K110.40953501
126MAP2K60.40102050
127MYLK0.39825900
128EPHB20.39361621
129MAP2K70.37919423
130EPHA40.37703249
131RPS6KA50.36805474
132RPS6KC10.35120581
133RPS6KL10.35120581
134CSNK1A10.34227262
135STK40.33187042
136MARK30.32876787
137DYRK20.32844345
138NEK60.32446791
139ERBB40.32318986
140CSF1R0.32222475
141RPS6KA60.32027042
142BRD40.31822864
143CSNK1D0.30632175
144FER0.29119311
145PRKDC0.28918298
146MAPKAPK50.28886746
147PRKACB0.28835843
148CDK10.28269287
149CDK30.27126884

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.52077296
2Proteasome_Homo sapiens_hsa030504.19614161
3Mismatch repair_Homo sapiens_hsa034303.86436136
4Ribosome_Homo sapiens_hsa030103.47055123
5RNA polymerase_Homo sapiens_hsa030203.10583586
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.05081276
7Spliceosome_Homo sapiens_hsa030402.98545765
8Homologous recombination_Homo sapiens_hsa034402.81241168
9Nucleotide excision repair_Homo sapiens_hsa034202.76481488
10* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.67724554
11Base excision repair_Homo sapiens_hsa034102.62631307
12Pyrimidine metabolism_Homo sapiens_hsa002402.56017222
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.55351370
14RNA transport_Homo sapiens_hsa030132.53100428
15Protein export_Homo sapiens_hsa030602.49102399
16Non-homologous end-joining_Homo sapiens_hsa034502.15189703
17Steroid biosynthesis_Homo sapiens_hsa001002.07575126
18Cell cycle_Homo sapiens_hsa041102.07013300
19Basal transcription factors_Homo sapiens_hsa030222.01777690
20One carbon pool by folate_Homo sapiens_hsa006702.00976286
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.98408979
22RNA degradation_Homo sapiens_hsa030181.81911517
23Fanconi anemia pathway_Homo sapiens_hsa034601.73521160
24Butanoate metabolism_Homo sapiens_hsa006501.69416255
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.61562801
26Purine metabolism_Homo sapiens_hsa002301.56119605
27Parkinsons disease_Homo sapiens_hsa050121.50669627
28Oxidative phosphorylation_Homo sapiens_hsa001901.41034509
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.34838639
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33193394
31Phototransduction_Homo sapiens_hsa047441.30158314
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.30049425
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22121541
34Selenocompound metabolism_Homo sapiens_hsa004501.20332619
35Huntingtons disease_Homo sapiens_hsa050161.16618798
36Folate biosynthesis_Homo sapiens_hsa007901.08954816
37p53 signaling pathway_Homo sapiens_hsa041151.07842807
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.03447960
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03062235
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02952353
41Carbon metabolism_Homo sapiens_hsa012000.99614521
42mRNA surveillance pathway_Homo sapiens_hsa030150.98439553
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95857221
44Fructose and mannose metabolism_Homo sapiens_hsa000510.95112235
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94572502
46Pentose phosphate pathway_Homo sapiens_hsa000300.92414314
47Epstein-Barr virus infection_Homo sapiens_hsa051690.91812075
48Biosynthesis of amino acids_Homo sapiens_hsa012300.91222387
49N-Glycan biosynthesis_Homo sapiens_hsa005100.90008643
50Vitamin B6 metabolism_Homo sapiens_hsa007500.89682840
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86718354
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85239982
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.84891411
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84530484
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83912661
56Fatty acid metabolism_Homo sapiens_hsa012120.80711915
57Retinol metabolism_Homo sapiens_hsa008300.80162520
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.80067570
59Galactose metabolism_Homo sapiens_hsa000520.79834663
60Antigen processing and presentation_Homo sapiens_hsa046120.77956510
61Caffeine metabolism_Homo sapiens_hsa002320.77890100
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77598431
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75336883
64Chemical carcinogenesis_Homo sapiens_hsa052040.74430578
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74303453
66Glutathione metabolism_Homo sapiens_hsa004800.73556560
67Pyruvate metabolism_Homo sapiens_hsa006200.72075566
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71848154
69Herpes simplex infection_Homo sapiens_hsa051680.70955598
70Sulfur relay system_Homo sapiens_hsa041220.69129995
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69067836
72TGF-beta signaling pathway_Homo sapiens_hsa043500.66883682
73Alzheimers disease_Homo sapiens_hsa050100.65959772
74Metabolic pathways_Homo sapiens_hsa011000.64592180
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63768113
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62902216
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61776122
78Regulation of autophagy_Homo sapiens_hsa041400.61694117
79Circadian rhythm_Homo sapiens_hsa047100.61476670
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61279672
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60931656
82Legionellosis_Homo sapiens_hsa051340.60631885
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.60313846
84Collecting duct acid secretion_Homo sapiens_hsa049660.59062900
85Systemic lupus erythematosus_Homo sapiens_hsa053220.58433353
86Nitrogen metabolism_Homo sapiens_hsa009100.56314976
87Fat digestion and absorption_Homo sapiens_hsa049750.56026878
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55877368
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55629514
90Hedgehog signaling pathway_Homo sapiens_hsa043400.54547814
91Thyroid cancer_Homo sapiens_hsa052160.51685262
92Hippo signaling pathway_Homo sapiens_hsa043900.46402309
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46328388
94Viral carcinogenesis_Homo sapiens_hsa052030.46072394
95Oocyte meiosis_Homo sapiens_hsa041140.45153688
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44247821
97Basal cell carcinoma_Homo sapiens_hsa052170.44142756
98Peroxisome_Homo sapiens_hsa041460.43134945
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42737348
100Propanoate metabolism_Homo sapiens_hsa006400.41025629
101Ether lipid metabolism_Homo sapiens_hsa005650.40993634
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40716592
103Other glycan degradation_Homo sapiens_hsa005110.40177271
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39100232
105Starch and sucrose metabolism_Homo sapiens_hsa005000.38677909
106Cardiac muscle contraction_Homo sapiens_hsa042600.37737479
107Arachidonic acid metabolism_Homo sapiens_hsa005900.36586876
108Primary immunodeficiency_Homo sapiens_hsa053400.36150672
109Linoleic acid metabolism_Homo sapiens_hsa005910.35051015
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34111740
111Olfactory transduction_Homo sapiens_hsa047400.33681438
112Wnt signaling pathway_Homo sapiens_hsa043100.32570220
113Fatty acid degradation_Homo sapiens_hsa000710.24905597
114Renin-angiotensin system_Homo sapiens_hsa046140.24870597
115Sulfur metabolism_Homo sapiens_hsa009200.24044943
116Arginine and proline metabolism_Homo sapiens_hsa003300.23186747
117Vitamin digestion and absorption_Homo sapiens_hsa049770.20824930
118Type I diabetes mellitus_Homo sapiens_hsa049400.20579623
119HTLV-I infection_Homo sapiens_hsa051660.19922553
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19873765
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19721779
122Alcoholism_Homo sapiens_hsa050340.19296574
123Vibrio cholerae infection_Homo sapiens_hsa051100.13843128
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13004233
125Fatty acid elongation_Homo sapiens_hsa000620.12050914
126Apoptosis_Homo sapiens_hsa042100.08938521
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.08697834
128Measles_Homo sapiens_hsa051620.07396439
129beta-Alanine metabolism_Homo sapiens_hsa004100.06099089
130HIF-1 signaling pathway_Homo sapiens_hsa040660.05601937
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.05425598
132Sphingolipid metabolism_Homo sapiens_hsa006000.04488203
133Tryptophan metabolism_Homo sapiens_hsa003800.04085935
134Tyrosine metabolism_Homo sapiens_hsa003500.02570844

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