RARSP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.06366089
2G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.54771114
3tryptophan metabolic process (GO:0006568)4.42601251
4glycoprotein catabolic process (GO:0006516)4.38316385
5replication fork processing (GO:0031297)4.37342834
6behavioral response to ethanol (GO:0048149)4.18455571
7oxidative demethylation (GO:0070989)3.82064247
8regulation of centriole replication (GO:0046599)3.79506385
9protein localization to cilium (GO:0061512)3.76998514
10indole-containing compound catabolic process (GO:0042436)3.74170219
11indolalkylamine catabolic process (GO:0046218)3.74170219
12tryptophan catabolic process (GO:0006569)3.74170219
13lysine catabolic process (GO:0006554)3.73219438
14lysine metabolic process (GO:0006553)3.73219438
15proteasome assembly (GO:0043248)3.72403657
16negative regulation of mast cell activation (GO:0033004)3.67927250
17response to pheromone (GO:0019236)3.60253889
18synapsis (GO:0007129)3.58368093
19indolalkylamine metabolic process (GO:0006586)3.57669105
20phosphatidylserine acyl-chain remodeling (GO:0036150)3.52153711
21negative regulation of T-helper cell differentiation (GO:0045623)3.43133360
22negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.43133360
23DNA replication-dependent nucleosome assembly (GO:0006335)3.42405046
24DNA replication-dependent nucleosome organization (GO:0034723)3.42405046
25ADP metabolic process (GO:0046031)3.39744260
26kynurenine metabolic process (GO:0070189)3.26567582
27auditory receptor cell stereocilium organization (GO:0060088)3.26255949
28DNA demethylation (GO:0080111)3.24164297
29aspartate family amino acid catabolic process (GO:0009068)3.20874202
30heparin biosynthetic process (GO:0030210)3.20083251
31heparin metabolic process (GO:0030202)3.20083251
32protein complex biogenesis (GO:0070271)3.16747007
33DNA deamination (GO:0045006)3.14017451
34negative regulation of acute inflammatory response (GO:0002674)3.12677010
35positive regulation of granulocyte differentiation (GO:0030854)3.11036942
36retinal rod cell development (GO:0046548)3.10982956
37secondary metabolite biosynthetic process (GO:0044550)3.10611142
38cytochrome complex assembly (GO:0017004)3.10353220
39serotonin receptor signaling pathway (GO:0007210)3.05499433
40respiratory chain complex IV assembly (GO:0008535)3.01672465
41protein polyglutamylation (GO:0018095)3.00783778
42centriole replication (GO:0007099)3.00145637
43response to gravity (GO:0009629)2.97937871
44behavioral response to nicotine (GO:0035095)2.93898165
45rRNA catabolic process (GO:0016075)2.92752665
46detection of light stimulus involved in sensory perception (GO:0050962)2.91443410
47detection of light stimulus involved in visual perception (GO:0050908)2.91443410
48maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89380828
49mitochondrial respiratory chain complex assembly (GO:0033108)2.89206507
50negative regulation of cytosolic calcium ion concentration (GO:0051481)2.88761317
51photoreceptor cell differentiation (GO:0046530)2.87480389
52eye photoreceptor cell differentiation (GO:0001754)2.87480389
53prenylation (GO:0097354)2.80185433
54protein prenylation (GO:0018342)2.80185433
55purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.79511649
56DNA dealkylation (GO:0035510)2.79260016
57AMP metabolic process (GO:0046033)2.76742643
58indole-containing compound metabolic process (GO:0042430)2.76043001
59opioid receptor signaling pathway (GO:0038003)2.75460984
60regulation of non-canonical Wnt signaling pathway (GO:2000050)2.73468519
61protein targeting to lysosome (GO:0006622)2.71984526
62establishment of protein localization to vacuole (GO:0072666)2.71984526
63protein targeting to vacuole (GO:0006623)2.71984526
64phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.71966341
65transmission of nerve impulse (GO:0019226)2.71615351
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66988997
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66988997
68regulation of isotype switching to IgG isotypes (GO:0048302)2.65514106
69L-fucose catabolic process (GO:0042355)2.64894408
70fucose catabolic process (GO:0019317)2.64894408
71L-fucose metabolic process (GO:0042354)2.64894408
72negative regulation of axon guidance (GO:1902668)2.64381421
73negative regulation of neurological system process (GO:0031645)2.63959391
74establishment of protein localization to mitochondrial membrane (GO:0090151)2.63909160
75mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.63907054
76mitochondrial respiratory chain complex I assembly (GO:0032981)2.63907054
77NADH dehydrogenase complex assembly (GO:0010257)2.63907054
78reciprocal DNA recombination (GO:0035825)2.62425346
79reciprocal meiotic recombination (GO:0007131)2.62425346
80detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61414755
81activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.61180640
82retinal cone cell development (GO:0046549)2.61038450
83negative regulation of nitric oxide biosynthetic process (GO:0045019)2.59454952
84regulation of clathrin-mediated endocytosis (GO:2000369)2.59335116
85multicellular organism reproduction (GO:0032504)2.59129110
86regulation of collateral sprouting (GO:0048670)2.58866255
87neuronal action potential (GO:0019228)2.58183266
88cGMP metabolic process (GO:0046068)2.56555920
89branched-chain amino acid catabolic process (GO:0009083)2.56047038
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.54477957
91purine deoxyribonucleotide metabolic process (GO:0009151)2.54469240
92sequestering of actin monomers (GO:0042989)2.53649345
93inner ear receptor stereocilium organization (GO:0060122)2.53576394
94regulation of translation in response to stress (GO:0043555)2.52576569
95T-helper cell differentiation (GO:0042093)2.52399177
96CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.52399177
97cytokine biosynthetic process (GO:0042089)2.52118563
98L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.49945805
99cell wall macromolecule catabolic process (GO:0016998)13.9494123
100cell wall macromolecule metabolic process (GO:0044036)11.5590512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.46718014
2VDR_22108803_ChIP-Seq_LS180_Human3.30732486
3ZNF274_21170338_ChIP-Seq_K562_Hela3.21770410
4FUS_26573619_Chip-Seq_HEK293_Human3.01110737
5GBX2_23144817_ChIP-Seq_PC3_Human2.88176282
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.85887441
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83703298
8TAF15_26573619_Chip-Seq_HEK293_Human2.65468389
9IGF1R_20145208_ChIP-Seq_DFB_Human2.61114733
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.51202052
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.47327874
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46579783
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40847756
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22097736
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.18475877
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15218216
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14458864
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11179323
19TP53_16413492_ChIP-PET_HCT116_Human2.02442604
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90825478
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90762189
22P300_19829295_ChIP-Seq_ESCs_Human1.87952339
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85655882
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.82666630
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81934485
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81116686
27EWS_26573619_Chip-Seq_HEK293_Human1.80586317
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76844548
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73010737
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.64763390
31POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.63541852
32TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63541852
33SMAD4_21799915_ChIP-Seq_A2780_Human1.62587192
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.58500226
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.56443848
36TCF4_23295773_ChIP-Seq_U87_Human1.56266043
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55486779
38CBP_20019798_ChIP-Seq_JUKART_Human1.54959040
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54959040
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53834996
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53711519
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53180325
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52301397
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48372671
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47439838
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46964521
47ER_23166858_ChIP-Seq_MCF-7_Human1.44644455
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.43644857
49TCF4_22108803_ChIP-Seq_LS180_Human1.41879407
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.41378321
51BCAT_22108803_ChIP-Seq_LS180_Human1.39110007
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.38959926
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36727277
54TP53_22573176_ChIP-Seq_HFKS_Human1.36104029
55STAT3_23295773_ChIP-Seq_U87_Human1.34639392
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34033399
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33803807
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30544221
59AR_20517297_ChIP-Seq_VCAP_Human1.29659885
60NANOG_19829295_ChIP-Seq_ESCs_Human1.28801702
61SOX2_19829295_ChIP-Seq_ESCs_Human1.28801702
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28524444
63MYC_18940864_ChIP-ChIP_HL60_Human1.26848052
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.25958998
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25890202
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23609019
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22279417
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21828770
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21759022
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.18916833
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.18158772
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16617987
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15180888
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.14706622
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13520754
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11604187
77AR_25329375_ChIP-Seq_VCAP_Human1.10682725
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10430488
79CDX2_22108803_ChIP-Seq_LS180_Human1.09422055
80FOXA1_25329375_ChIP-Seq_VCAP_Human1.09026651
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09026651
82RUNX2_22187159_ChIP-Seq_PCA_Human1.05488500
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.04896639
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04675957
85ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03851370
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.02860180
87SMAD3_21741376_ChIP-Seq_HESCs_Human0.97021616
88VDR_23849224_ChIP-Seq_CD4+_Human0.96409739
89E2F1_18555785_Chip-Seq_ESCs_Mouse0.94528431
90OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94242818
91SMAD4_21741376_ChIP-Seq_EPCs_Human0.93393919
92NFYB_21822215_ChIP-Seq_K562_Human0.93313318
93ELK1_19687146_ChIP-ChIP_HELA_Human0.91714697
94HOXB7_26014856_ChIP-Seq_BT474_Human0.91470207
95ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91325787
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90397055
97NCOR_22424771_ChIP-Seq_293T_Human0.90348837
98CMYC_18555785_Chip-Seq_ESCs_Mouse0.90286653
99SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89775586
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89172530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting6.50886329
2MP0000372_irregular_coat_pigmentation5.00059678
3MP0003172_abnormal_lysosome_physiology4.06639443
4MP0008875_abnormal_xenobiotic_pharmacok4.03905444
5MP0003718_maternal_effect2.96483576
6MP0000569_abnormal_digit_pigmentation2.91001790
7MP0001968_abnormal_touch/_nociception2.80176486
8MP0005646_abnormal_pituitary_gland2.71205061
9MP0008872_abnormal_physiological_respon2.54591907
10MP0005075_abnormal_melanosome_morpholog2.49031519
11MP0005171_absent_coat_pigmentation2.45006727
12MP0005360_urolithiasis2.37527446
13MP0004270_analgesia2.20802161
14MP0002736_abnormal_nociception_after2.19007403
15MP0008877_abnormal_DNA_methylation2.15806140
16MP0003191_abnormal_cellular_cholesterol2.15759460
17MP0003121_genomic_imprinting2.13007360
18MP0002653_abnormal_ependyma_morphology2.07974916
19MP0000015_abnormal_ear_pigmentation1.98784130
20MP0005551_abnormal_eye_electrophysiolog1.92006270
21MP0003806_abnormal_nucleotide_metabolis1.90298391
22MP0005408_hypopigmentation1.90124511
23MP0003880_abnormal_central_pattern1.84679075
24MP0000681_abnormal_thyroid_gland1.82513416
25MP0002938_white_spotting1.80254461
26MP0005174_abnormal_tail_pigmentation1.66622642
27MP0004142_abnormal_muscle_tone1.48120294
28MP0001348_abnormal_lacrimal_gland1.46525173
29MP0001984_abnormal_olfaction1.46402720
30MP0002234_abnormal_pharynx_morphology1.45974189
31MP0009745_abnormal_behavioral_response1.44093466
32MP0002095_abnormal_skin_pigmentation1.43503149
33MP0004147_increased_porphyrin_level1.43439916
34MP0001529_abnormal_vocalization1.40644883
35MP0001764_abnormal_homeostasis1.37383280
36MP0005395_other_phenotype1.26532138
37MP0003950_abnormal_plasma_membrane1.23115865
38MP0002734_abnormal_mechanical_nocicepti1.22567099
39MP0002733_abnormal_thermal_nociception1.21358898
40MP0009046_muscle_twitch1.21140215
41MP0001324_abnormal_eye_pigmentation1.19516005
42MP0000371_diluted_coat_color1.17868705
43MP0003195_calcinosis1.17273540
44MP0001835_abnormal_antigen_presentation1.15249896
45MP0004484_altered_response_of1.10957471
46MP0001486_abnormal_startle_reflex1.10631628
47MP0003011_delayed_dark_adaptation1.09749433
48MP0001986_abnormal_taste_sensitivity1.05905361
49MP0001501_abnormal_sleep_pattern1.05714759
50MP0001873_stomach_inflammation1.05517870
51MP0004924_abnormal_behavior1.04608727
52MP0005386_behavior/neurological_phenoty1.04608727
53MP0005379_endocrine/exocrine_gland_phen1.03912225
54MP0005367_renal/urinary_system_phenotyp1.00842366
55MP0000516_abnormal_urinary_system1.00842366
56MP0003646_muscle_fatigue0.97630695
57MP0006276_abnormal_autonomic_nervous0.97616305
58MP0000955_abnormal_spinal_cord0.96054130
59MP0008775_abnormal_heart_ventricle0.95594194
60MP0002735_abnormal_chemical_nociception0.95153911
61MP0005253_abnormal_eye_physiology0.94673259
62MP0005084_abnormal_gallbladder_morpholo0.93462605
63MP0002837_dystrophic_cardiac_calcinosis0.91990223
64MP0002928_abnormal_bile_duct0.91577283
65MP0004084_abnormal_cardiac_muscle0.90817521
66MP0008058_abnormal_DNA_repair0.90652312
67MP0002272_abnormal_nervous_system0.87157633
68MP0003186_abnormal_redox_activity0.86265837
69MP0006292_abnormal_olfactory_placode0.86076984
70MP0000631_abnormal_neuroendocrine_gland0.85470081
71MP0004043_abnormal_pH_regulation0.83827228
72MP0002163_abnormal_gland_morphology0.82942240
73MP0002876_abnormal_thyroid_physiology0.81336141
74MP0002138_abnormal_hepatobiliary_system0.80788269
75MP0004145_abnormal_muscle_electrophysio0.80234346
76MP0002067_abnormal_sensory_capabilities0.77796323
77MP0001970_abnormal_pain_threshold0.77740586
78MP0005645_abnormal_hypothalamus_physiol0.75221634
79MP0005377_hearing/vestibular/ear_phenot0.74968794
80MP0003878_abnormal_ear_physiology0.74968794
81MP0003635_abnormal_synaptic_transmissio0.74789425
82MP0002693_abnormal_pancreas_physiology0.74118322
83MP0006036_abnormal_mitochondrial_physio0.73470652
84MP0001485_abnormal_pinna_reflex0.72910047
85MP0001293_anophthalmia0.71067092
86MP0009780_abnormal_chondrocyte_physiolo0.69286308
87MP0002160_abnormal_reproductive_system0.68869408
88MP0002064_seizures0.68290981
89MP0005636_abnormal_mineral_homeostasis0.68181963
90MP0002090_abnormal_vision0.67171483
91MP0004215_abnormal_myocardial_fiber0.63208710
92MP0002075_abnormal_coat/hair_pigmentati0.62589837
93MP0004036_abnormal_muscle_relaxation0.62540086
94MP0002572_abnormal_emotion/affect_behav0.61999015
95MP0002063_abnormal_learning/memory/cond0.61649124
96MP0009697_abnormal_copulation0.61630498
97MP0010094_abnormal_chromosome_stability0.61592982
98MP0000427_abnormal_hair_cycle0.60634659
99MP0004742_abnormal_vestibular_system0.58379814
100MP0000383_abnormal_hair_follicle0.58251598

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)4.97500817
2True hermaphroditism (HP:0010459)4.86057550
3Pancreatic cysts (HP:0001737)4.59579989
4Oligodactyly (hands) (HP:0001180)4.37918793
5Cystic liver disease (HP:0006706)3.86734378
6Chronic hepatic failure (HP:0100626)3.76267528
7Congenital stationary night blindness (HP:0007642)3.51196681
8Focal motor seizures (HP:0011153)3.30148006
9Abnormality of the vasculature of the conjunctiva (HP:0008054)3.29670278
10Aplasia/Hypoplasia of the tongue (HP:0010295)3.26924848
11Stenosis of the external auditory canal (HP:0000402)3.19344538
12Oligodactyly (HP:0012165)3.14742643
13Furrowed tongue (HP:0000221)3.06994631
14Diastasis recti (HP:0001540)2.98378328
15Anencephaly (HP:0002323)2.90668677
16Cutaneous melanoma (HP:0012056)2.87797116
17Abnormality of midbrain morphology (HP:0002418)2.86354975
18Molar tooth sign on MRI (HP:0002419)2.86354975
19Occipital encephalocele (HP:0002085)2.84574529
20Anophthalmia (HP:0000528)2.80832785
21Hypoproteinemia (HP:0003075)2.77207994
22Congenital hepatic fibrosis (HP:0002612)2.74313132
23Thyroid-stimulating hormone excess (HP:0002925)2.69236100
24Sclerocornea (HP:0000647)2.68611537
25Insulin-resistant diabetes mellitus (HP:0000831)2.62713858
26Type 2 muscle fiber atrophy (HP:0003554)2.62678461
27Gaze-evoked nystagmus (HP:0000640)2.60005967
28Abnormal biliary tract physiology (HP:0012439)2.57582193
29Bile duct proliferation (HP:0001408)2.57582193
30Hypothermia (HP:0002045)2.53607898
31Postaxial foot polydactyly (HP:0001830)2.52541283
32Hypoplastic pelvis (HP:0008839)2.52328367
33Colon cancer (HP:0003003)2.51317979
34Attenuation of retinal blood vessels (HP:0007843)2.43133241
35Abnormality of macular pigmentation (HP:0008002)2.38060919
36Type II lissencephaly (HP:0007260)2.37208308
37Inability to walk (HP:0002540)2.35636602
38Disproportionate short-trunk short stature (HP:0003521)2.32168301
39Aplasia/Hypoplasia of the spleen (HP:0010451)2.31206804
40Decreased central vision (HP:0007663)2.26112308
41Generalized hypopigmentation (HP:0007513)2.24598270
42Medial flaring of the eyebrow (HP:0010747)2.18075863
43Poor head control (HP:0002421)2.14826523
44Nephronophthisis (HP:0000090)2.12819360
45Progressive macrocephaly (HP:0004481)2.10124224
46Abnormality of the fovea (HP:0000493)2.09470438
47Albinism (HP:0001022)2.09267516
48Bony spicule pigmentary retinopathy (HP:0007737)2.09035429
49Asplenia (HP:0001746)2.06764954
50Muscle fiber atrophy (HP:0100295)2.06689192
51Optic nerve hypoplasia (HP:0000609)2.06678461
52Focal seizures (HP:0007359)2.06259474
53Acute hepatic failure (HP:0006554)2.06149796
54Male pseudohermaphroditism (HP:0000037)2.05500886
55Abnormal pancreas size (HP:0012094)2.05447472
56Ependymoma (HP:0002888)2.05275515
57Mesomelia (HP:0003027)2.04926849
58Hypoplasia of the fovea (HP:0007750)2.03125876
59Aplasia/Hypoplasia of the fovea (HP:0008060)2.03125876
60Choroideremia (HP:0001139)2.02562561
61Hyperglycinuria (HP:0003108)2.02360124
62Septo-optic dysplasia (HP:0100842)1.99507271
63Popliteal pterygium (HP:0009756)1.96718182
64Abnormal rod and cone electroretinograms (HP:0008323)1.95975508
65Pendular nystagmus (HP:0012043)1.95187884
66Hypoalbuminemia (HP:0003073)1.94072498
67Abnormal albumin level (HP:0012116)1.94072498
68Thyroiditis (HP:0100646)1.93278821
69Acute necrotizing encephalopathy (HP:0006965)1.91058879
70Chromsome breakage (HP:0040012)1.90470027
71Hypokalemic alkalosis (HP:0001949)1.88448853
72Hamartoma of the eye (HP:0010568)1.87755366
73Absent speech (HP:0001344)1.87710408
74Generalized hypopigmentation of hair (HP:0011358)1.86655025
75Abnormal tarsal ossification (HP:0008369)1.86562515
76Generalized tonic-clonic seizures (HP:0002069)1.86302453
77Increased CSF lactate (HP:0002490)1.86282559
78Spinal muscular atrophy (HP:0007269)1.84081291
79Oculomotor apraxia (HP:0000657)1.83969487
80Neonatal respiratory distress (HP:0002643)1.83899054
81Panhypogammaglobulinemia (HP:0003139)1.81594425
82Carpal bone hypoplasia (HP:0001498)1.81181675
83Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81156795
84Acute encephalopathy (HP:0006846)1.80095675
85Unsteady gait (HP:0002317)1.77148624
86Brittle hair (HP:0002299)1.74525748
87Abnormality of the renal medulla (HP:0100957)1.72910382
88Aqueductal stenosis (HP:0002410)1.71411237
89Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.71385644
90Preaxial hand polydactyly (HP:0001177)1.70711947
91Supernumerary spleens (HP:0009799)1.70221558
92Neoplasm of the adrenal cortex (HP:0100641)1.69930699
93Vaginal atresia (HP:0000148)1.69608135
94Postaxial hand polydactyly (HP:0001162)1.69473426
95Genital tract atresia (HP:0001827)1.69402136
96Hematochezia (HP:0002573)1.68827456
97Split foot (HP:0001839)1.68647227
98Gait imbalance (HP:0002141)1.68615837
99Poor speech (HP:0002465)1.67556522
100Abnormality of the anterior horn cell (HP:0006802)1.66496747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.13513834
2EIF2AK34.28892871
3TNIK3.76066255
4WNK33.19454445
5BMPR1B2.59480743
6MST42.56067344
7EPHA42.12668268
8NUAK12.11213082
9MAPK132.09121017
10ADRBK22.05220279
11VRK22.01572632
12FGFR21.86366713
13BRD41.55290966
14CCNB11.54564732
15MKNK21.51823665
16TAOK31.50049814
17STK38L1.43468524
18IRAK11.42442253
19MARK11.41094063
20ERBB31.40126063
21TGFBR11.39195913
22PLK21.37794318
23OXSR11.37744743
24PBK1.32858489
25STK391.24640953
26CASK1.24571727
27GRK11.21445204
28CLK11.21173325
29TXK1.17234695
30FER1.13376587
31TGFBR21.10110455
32GRK71.10101615
33PNCK1.09913876
34PHKG11.01657156
35PHKG21.01657156
36TIE11.00495120
37PLK30.97894458
38MKNK10.96896410
39MAP4K20.92906441
40ACVR1B0.90760541
41IKBKB0.89238178
42NTRK30.87121628
43PRKCE0.86956721
44DYRK20.84925328
45GRK50.81595697
46NTRK20.80364729
47CSF1R0.78280001
48VRK10.77324110
49TNK20.76391264
50ADRBK10.75518357
51PRKCG0.73796099
52TRPM70.72352191
53BRSK20.72286818
54TSSK60.71760161
55WNK40.69820459
56MAP3K30.67572072
57CSNK1G20.67200187
58CDK30.66596706
59INSRR0.66375399
60STK160.64277995
61CSNK1G30.63107928
62MINK10.62025473
63BCKDK0.61302900
64PRKCI0.56779064
65MUSK0.55565890
66ITK0.55127624
67SIK20.54230432
68TAF10.53338027
69ABL10.52688658
70CSNK1A1L0.50799807
71DAPK20.50769196
72CSNK1G10.49855370
73TEC0.49218169
74CDK80.48092318
75CAMK2A0.43809143
76CDK190.43337558
77PTK2B0.42690094
78LYN0.41608831
79PIK3CG0.40597876
80MARK30.39477647
81PAK30.38151834
82CAMK40.37040369
83ATR0.35877535
84CAMK1G0.35552053
85MAPK70.35551676
86ATM0.34882347
87MAPKAPK30.34729632
88CDK180.34596294
89STK110.34289957
90FES0.33636635
91EIF2AK10.33583800
92CSNK1A10.33051165
93CDK11A0.32974314
94CDK150.32843950
95PAK60.32460282
96CDK140.29982909
97DYRK1A0.29366760
98NME10.29272363
99MAP3K40.28712117
100PRKCA0.28666204

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.61715562
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.95642824
3Non-homologous end-joining_Homo sapiens_hsa034502.90937170
4Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.75774035
5Homologous recombination_Homo sapiens_hsa034402.73942127
6Allograft rejection_Homo sapiens_hsa053302.67374816
7Autoimmune thyroid disease_Homo sapiens_hsa053202.59648566
8Phototransduction_Homo sapiens_hsa047442.57319087
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.49376928
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.28497975
11Tryptophan metabolism_Homo sapiens_hsa003802.15354077
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.14736234
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13126378
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.94811670
15Fanconi anemia pathway_Homo sapiens_hsa034601.88256507
16Protein export_Homo sapiens_hsa030601.87122911
17Butanoate metabolism_Homo sapiens_hsa006501.81021676
18Linoleic acid metabolism_Homo sapiens_hsa005911.80538087
19RNA polymerase_Homo sapiens_hsa030201.69076556
20Propanoate metabolism_Homo sapiens_hsa006401.62259340
21Vitamin B6 metabolism_Homo sapiens_hsa007501.58434407
22Taste transduction_Homo sapiens_hsa047421.51730408
23Ether lipid metabolism_Homo sapiens_hsa005651.50553940
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47576675
25Nicotine addiction_Homo sapiens_hsa050331.43848713
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42566310
27Oxidative phosphorylation_Homo sapiens_hsa001901.35245932
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34341131
29Nitrogen metabolism_Homo sapiens_hsa009101.24882294
30Glycerolipid metabolism_Homo sapiens_hsa005611.23303850
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22833557
32beta-Alanine metabolism_Homo sapiens_hsa004101.22485259
33Other glycan degradation_Homo sapiens_hsa005111.21959383
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.20961631
35Antigen processing and presentation_Homo sapiens_hsa046121.19630695
36Caffeine metabolism_Homo sapiens_hsa002321.19325687
37Parkinsons disease_Homo sapiens_hsa050121.17970787
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17539065
39Graft-versus-host disease_Homo sapiens_hsa053321.16073621
40One carbon pool by folate_Homo sapiens_hsa006701.15468448
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12390531
42Fatty acid degradation_Homo sapiens_hsa000711.11878925
43Purine metabolism_Homo sapiens_hsa002301.10996967
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.10597804
45Collecting duct acid secretion_Homo sapiens_hsa049661.09230184
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09121025
47Type I diabetes mellitus_Homo sapiens_hsa049400.99571483
48Olfactory transduction_Homo sapiens_hsa047400.98938845
49Mineral absorption_Homo sapiens_hsa049780.96443832
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89276869
51Basal transcription factors_Homo sapiens_hsa030220.89065792
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.88875407
53Proteasome_Homo sapiens_hsa030500.85860246
54Pyrimidine metabolism_Homo sapiens_hsa002400.85047645
55GABAergic synapse_Homo sapiens_hsa047270.80256641
56Huntingtons disease_Homo sapiens_hsa050160.77417611
57Sulfur metabolism_Homo sapiens_hsa009200.76651820
58RNA transport_Homo sapiens_hsa030130.75718746
59Arachidonic acid metabolism_Homo sapiens_hsa005900.73260920
60Selenocompound metabolism_Homo sapiens_hsa004500.69488892
61Salivary secretion_Homo sapiens_hsa049700.67568682
62Morphine addiction_Homo sapiens_hsa050320.65362115
63Fatty acid biosynthesis_Homo sapiens_hsa000610.63461516
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63459937
65RNA degradation_Homo sapiens_hsa030180.63216229
66Circadian entrainment_Homo sapiens_hsa047130.62752531
67Sphingolipid metabolism_Homo sapiens_hsa006000.60419676
68Serotonergic synapse_Homo sapiens_hsa047260.60179302
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.60098110
70Rheumatoid arthritis_Homo sapiens_hsa053230.59876937
71Peroxisome_Homo sapiens_hsa041460.59374661
72Pyruvate metabolism_Homo sapiens_hsa006200.59300757
73Glutathione metabolism_Homo sapiens_hsa004800.59286070
74Alzheimers disease_Homo sapiens_hsa050100.56800870
75Metabolic pathways_Homo sapiens_hsa011000.52211916
76Chemical carcinogenesis_Homo sapiens_hsa052040.51973012
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51693987
78Lysine degradation_Homo sapiens_hsa003100.51002974
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48771066
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46947029
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45780694
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44492003
83Biosynthesis of amino acids_Homo sapiens_hsa012300.44206150
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43975592
85Arginine and proline metabolism_Homo sapiens_hsa003300.43688864
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43439931
87Glutamatergic synapse_Homo sapiens_hsa047240.42808352
88Cardiac muscle contraction_Homo sapiens_hsa042600.42423597
89Retinol metabolism_Homo sapiens_hsa008300.42133157
90Carbon metabolism_Homo sapiens_hsa012000.41606652
91Insulin secretion_Homo sapiens_hsa049110.40772452
92Base excision repair_Homo sapiens_hsa034100.40313802
93Primary immunodeficiency_Homo sapiens_hsa053400.40132107
94Ovarian steroidogenesis_Homo sapiens_hsa049130.38935047
95Fatty acid metabolism_Homo sapiens_hsa012120.38684255
96Nucleotide excision repair_Homo sapiens_hsa034200.37342472
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36587672
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36502595
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34958427
100Mismatch repair_Homo sapiens_hsa034300.33089213

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