RASA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)4.54428473
2hemidesmosome assembly (GO:0031581)4.12084069
3hypotonic response (GO:0006971)4.10395002
4estrogen biosynthetic process (GO:0006703)3.99262750
5protein localization to endosome (GO:0036010)3.80865749
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.78058692
7mesodermal cell differentiation (GO:0048333)3.43228564
8regulation of DNA endoreduplication (GO:0032875)3.37505185
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.30020975
10negative regulation of cell killing (GO:0031342)3.30020975
11cytoplasmic mRNA processing body assembly (GO:0033962)3.28882375
12nuclear pore complex assembly (GO:0051292)3.24479176
13pericardium development (GO:0060039)3.18958699
14skin morphogenesis (GO:0043589)3.17625797
15negative regulation of anoikis (GO:2000811)3.07290151
16negative regulation of neurotransmitter secretion (GO:0046929)3.04898474
17cell-substrate junction assembly (GO:0007044)3.02830634
18phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.02661789
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.01477550
20prostate gland growth (GO:0060736)3.01475982
21regulation of establishment of cell polarity (GO:2000114)3.00926774
22negative regulation of DNA-dependent DNA replication (GO:2000104)3.00889414
23positive regulation of dendritic spine morphogenesis (GO:0061003)3.00535163
24chondrocyte proliferation (GO:0035988)2.95659480
25sequestering of extracellular ligand from receptor (GO:0035581)2.94489874
26positive regulation of cardiac muscle cell differentiation (GO:2000727)2.90666430
27response to follicle-stimulating hormone (GO:0032354)2.81851891
28mRNA splice site selection (GO:0006376)2.79846575
29endodermal cell differentiation (GO:0035987)2.79477847
30nucleus localization (GO:0051647)2.76818771
31phospholipid translocation (GO:0045332)2.71521452
32lipid translocation (GO:0034204)2.71521452
33dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.71074411
34response to nerve growth factor (GO:1990089)2.69861328
35cellular response to nerve growth factor stimulus (GO:1990090)2.69861328
36myoblast fusion (GO:0007520)2.65583391
37retina vasculature morphogenesis in camera-type eye (GO:0061299)2.64536585
38sister chromatid cohesion (GO:0007062)2.62004860
39neuron projection extension involved in neuron projection guidance (GO:1902284)2.61396286
40axon extension involved in axon guidance (GO:0048846)2.61396286
41cytoskeletal anchoring at plasma membrane (GO:0007016)2.59222622
42regulation of gonadotropin secretion (GO:0032276)2.59099910
43sprouting angiogenesis (GO:0002040)2.59017665
44nuclear pore organization (GO:0006999)2.58698895
45definitive hemopoiesis (GO:0060216)2.58337070
46pore complex assembly (GO:0046931)2.57905221
47tyrosine phosphorylation of STAT protein (GO:0007260)2.55856608
48myelin assembly (GO:0032288)2.52568828
49platelet-derived growth factor receptor signaling pathway (GO:0048008)2.51728960
50axon extension (GO:0048675)2.50408679
51nerve growth factor signaling pathway (GO:0038180)2.50117393
52regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.49612185
53clathrin coat assembly (GO:0048268)2.48299566
54collagen fibril organization (GO:0030199)2.47588916
55regulation of protein polyubiquitination (GO:1902914)2.47546974
56regulation of NFAT protein import into nucleus (GO:0051532)2.47078298
57syncytium formation by plasma membrane fusion (GO:0000768)2.45143920
58lymphangiogenesis (GO:0001946)2.44659014
59peptidyl-threonine modification (GO:0018210)2.43045042
60COPII vesicle coating (GO:0048208)2.42391518
61protein targeting to Golgi (GO:0000042)2.42175608
62cerebral cortex radially oriented cell migration (GO:0021799)2.41852118
63retrograde transport, vesicle recycling within Golgi (GO:0000301)2.41594225
64substrate-dependent cell migration (GO:0006929)2.40570171
65female pregnancy (GO:0007565)2.40275351
66protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.39910097
67establishment of protein localization to Golgi (GO:0072600)2.37415967
68syncytium formation (GO:0006949)2.36245196
69positive regulation of muscle hypertrophy (GO:0014742)2.35368612
70positive regulation of cardiac muscle hypertrophy (GO:0010613)2.35368612
71regulation of anoikis (GO:2000209)2.35173271
72embryonic process involved in female pregnancy (GO:0060136)2.34911533
73negative regulation of DNA repair (GO:0045738)2.34666274
74regulation of RNA export from nucleus (GO:0046831)2.34498923
75regulation of establishment or maintenance of cell polarity (GO:0032878)2.34342710
76negative regulation of fibroblast apoptotic process (GO:2000270)2.32556156
77germ cell migration (GO:0008354)2.32174952
78insulin-like growth factor receptor signaling pathway (GO:0048009)2.32117984
79peptidyl-threonine phosphorylation (GO:0018107)2.30883448
80axonal fasciculation (GO:0007413)2.30724333
81regulation of growth hormone secretion (GO:0060123)2.30140125
82kinetochore organization (GO:0051383)2.30022252
83embryonic camera-type eye morphogenesis (GO:0048596)2.29470709
84inner ear receptor cell development (GO:0060119)2.28373084
85negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.27994258
86negative regulation of translation, ncRNA-mediated (GO:0040033)2.27994258
87regulation of translation, ncRNA-mediated (GO:0045974)2.27994258
88vascular endothelial growth factor signaling pathway (GO:0038084)2.27267021
89actin cytoskeleton reorganization (GO:0031532)2.25902652
90positive regulation of receptor recycling (GO:0001921)2.24896504
91ganglion development (GO:0061548)2.24285177
92regulation of Rac protein signal transduction (GO:0035020)2.24001257
93negative regulation of chondrocyte differentiation (GO:0032331)2.23909585
94regulation of fibroblast apoptotic process (GO:2000269)2.23765915
95negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.22942632
96central nervous system projection neuron axonogenesis (GO:0021952)2.22642715
97neural tube formation (GO:0001841)2.21789464
98negative regulation of osteoblast proliferation (GO:0033689)2.21239413
99lung lobe morphogenesis (GO:0060463)2.20691939
100synapsis (GO:0007129)2.18459845
101regulation of sister chromatid cohesion (GO:0007063)2.18003825
102regulation of meiosis I (GO:0060631)2.17404867
103positive regulation of mitotic sister chromatid separation (GO:1901970)2.16093403
104positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.16093403
105positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.16093403
106meiotic chromosome segregation (GO:0045132)2.15760827
107poly(A)+ mRNA export from nucleus (GO:0016973)2.15573799
108import into cell (GO:0098657)2.15492852
109DNA strand renaturation (GO:0000733)2.14967952
110mitotic cell cycle arrest (GO:0071850)2.14697222
111cell adhesion mediated by integrin (GO:0033627)2.14063436
112smooth muscle tissue development (GO:0048745)2.13748676
113SMAD protein complex assembly (GO:0007183)2.13067581
114pathway-restricted SMAD protein phosphorylation (GO:0060389)2.12978572
115Golgi to endosome transport (GO:0006895)2.12737519
116regulation of germinal center formation (GO:0002634)2.12381927
117neuron projection extension (GO:1990138)2.12032728
118regulation of chemokine-mediated signaling pathway (GO:0070099)2.11965377
119glycoprotein catabolic process (GO:0006516)2.11438605
120regulation of centriole replication (GO:0046599)2.11027511
121chondrocyte development (GO:0002063)2.10852114
122vesicle transport along microtubule (GO:0047496)2.10824851
123negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.10662146
124positive regulation of fibroblast migration (GO:0010763)2.09679279
125adherens junction assembly (GO:0034333)2.09555435
126resolution of meiotic recombination intermediates (GO:0000712)2.09237457
127hippo signaling (GO:0035329)2.08796307
128coronary vasculature morphogenesis (GO:0060977)2.08450818
129mitotic chromosome condensation (GO:0007076)2.08243633
130corticosteroid receptor signaling pathway (GO:0031958)2.07993226
131microtubule nucleation (GO:0007020)2.07211704
132B cell homeostasis (GO:0001782)2.07010521
133positive regulation of dendrite morphogenesis (GO:0050775)2.06387446
134monoubiquitinated protein deubiquitination (GO:0035520)2.05940207
135histone H3-K9 demethylation (GO:0033169)2.04198865
136regulation of dendritic spine morphogenesis (GO:0061001)2.04054691
137kidney morphogenesis (GO:0060993)2.03752800
138regulation of transforming growth factor beta2 production (GO:0032909)2.03653175
139NLS-bearing protein import into nucleus (GO:0006607)2.02606073
140positive regulation of mRNA catabolic process (GO:0061014)2.02528592
141histone H3-K9 methylation (GO:0051567)2.02237276
142regulation of nucleobase-containing compound transport (GO:0032239)2.02154446
143positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.01922098
144regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.01922098
145epithelial cell differentiation involved in kidney development (GO:0035850)2.01562740
146mitotic G2/M transition checkpoint (GO:0044818)2.00897569
147dendrite morphogenesis (GO:0048813)1.98606081
148mesenchymal-epithelial cell signaling (GO:0060638)1.97559750
149mitotic G2 DNA damage checkpoint (GO:0007095)1.97443089
150regulation of pigment cell differentiation (GO:0050932)1.97053726
151positive regulation of protein autophosphorylation (GO:0031954)1.96290679
152interkinetic nuclear migration (GO:0022027)1.95289395
153activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)1.95138397
154mesenchymal cell differentiation (GO:0048762)1.94272479
155regulation of telomere maintenance (GO:0032204)1.93941427
156glucocorticoid receptor signaling pathway (GO:0042921)1.93335627
157histone H3-K36 demethylation (GO:0070544)1.92542144
158anatomical structure arrangement (GO:0048532)1.92290309
159lens morphogenesis in camera-type eye (GO:0002089)1.92040783
160metanephric mesenchyme development (GO:0072075)1.91990748
161histone H3-K4 trimethylation (GO:0080182)1.91869074
162negative regulation of activin receptor signaling pathway (GO:0032926)1.90379911
163establishment of nucleus localization (GO:0040023)1.90112942
164neuron recognition (GO:0008038)1.89835853
165embryonic viscerocranium morphogenesis (GO:0048703)1.89382341
166central nervous system neuron axonogenesis (GO:0021955)1.89340778
167histone-serine phosphorylation (GO:0035404)1.88344323
168Rap protein signal transduction (GO:0032486)1.88206726
169microglial cell activation (GO:0001774)1.87676452

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.98484319
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.29603815
3* CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.17077878
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.58795213
5GBX2_23144817_ChIP-Seq_PC3_Human2.53037737
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.52593916
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.49385735
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40285312
9EZH2_22144423_ChIP-Seq_EOC_Human2.27841101
10* FUS_26573619_Chip-Seq_HEK293_Human2.14612410
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08157688
12EWS_26573619_Chip-Seq_HEK293_Human2.03488330
13TP53_16413492_ChIP-PET_HCT116_Human2.03270789
14* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.98417206
15TAF15_26573619_Chip-Seq_HEK293_Human1.91480599
16EGR1_19374776_ChIP-ChIP_THP-1_Human1.88571361
17* P300_19829295_ChIP-Seq_ESCs_Human1.85569059
18* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81615887
19WT1_19549856_ChIP-ChIP_CCG9911_Human1.80130620
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.78789941
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.74822642
22TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.70394005
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.69428695
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67948508
25E2F7_22180533_ChIP-Seq_HELA_Human1.66593917
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.66396524
27SMAD4_21799915_ChIP-Seq_A2780_Human1.64560723
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.64300693
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.64144158
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64126561
31* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63878635
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.62937808
33SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.62937808
34CTNNB1_20460455_ChIP-Seq_HCT116_Human1.62080178
35* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60939209
36IGF1R_20145208_ChIP-Seq_DFB_Human1.59386191
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57415592
38* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52420599
39TP53_18474530_ChIP-ChIP_U2OS_Human1.51898122
40BCAT_22108803_ChIP-Seq_LS180_Human1.51012808
41* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49404122
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48689828
43* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.48054229
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48023954
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.47101975
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45521167
47AR_21572438_ChIP-Seq_LNCaP_Human1.42831609
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.41976883
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.39784103
50AHR_22903824_ChIP-Seq_MCF-7_Human1.37513049
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37183465
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.36430638
53* STAT3_23295773_ChIP-Seq_U87_Human1.36208804
54BRD4_25478319_ChIP-Seq_HGPS_Human1.34893235
55* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34477296
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32644138
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32615581
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.31769772
59RNF2_27304074_Chip-Seq_NSC_Mouse1.30874325
60AR_25329375_ChIP-Seq_VCAP_Human1.29766680
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.29370450
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27688185
63GATA1_22025678_ChIP-Seq_K562_Human1.27342132
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26042026
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25508267
66PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.24616750
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.24447022
68* TP63_23658742_ChIP-Seq_EP156T_Human1.24413523
69* CJUN_26792858_Chip-Seq_BT549_Human1.23663925
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.23247837
71TCF4_18268006_ChIP-ChIP_LS174T_Human1.23125696
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22910077
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.22902428
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22817601
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22800423
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22475742
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22267547
78ZNF274_21170338_ChIP-Seq_K562_Hela1.22169214
79SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20095870
80SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19998768
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19814130
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19814130
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19733880
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19430261
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.19339116
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18839462
87ER_23166858_ChIP-Seq_MCF-7_Human1.18405888
88* TCF4_23295773_ChIP-Seq_U87_Human1.18134432
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17631989
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17518976
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16392903
92FOXM1_23109430_ChIP-Seq_U2OS_Human1.16085233
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15533756
94* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14338329
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.13699789
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12924717
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12652731
98DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12352574
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11230801
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11082013
101NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11082013
102YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10857480
103FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.10477546
104P53_22387025_ChIP-Seq_ESCs_Mouse1.10015939
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09709932
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09424379
107SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09294386
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.09155433
109CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08838204
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08529490
111SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07966616
112JUN_21703547_ChIP-Seq_K562_Human1.07831400
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07481402
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07361141
115SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07139461
116RUNX2_22187159_ChIP-Seq_PCA_Human1.06905310
117* RUNX_20019798_ChIP-Seq_JUKART_Human1.06582133
118VDR_24787735_ChIP-Seq_THP-1_Human1.06081395
119PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06016784
120RXR_22108803_ChIP-Seq_LS180_Human1.06007563
121CLOCK_20551151_ChIP-Seq_293T_Human1.05927835
122BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05667097
123FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05222196
124SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04461554
125NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04387886
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04328124
127* SOX2_21211035_ChIP-Seq_LN229_Gbm1.04082902
128BP1_19119308_ChIP-ChIP_Hs578T_Human1.02606458
129TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01850263
130RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01404683
131TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01109735
132* TCF4_22108803_ChIP-Seq_LS180_Human1.00916149
133* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00360721
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.99061024
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98956809
136KDM2B_26808549_Chip-Seq_REH_Human0.98621354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.57646897
2MP0009697_abnormal_copulation3.57295313
3MP0003787_abnormal_imprinting3.26163365
4MP0003950_abnormal_plasma_membrane3.18220117
5MP0003566_abnormal_cell_adhesion2.84647206
6MP0005171_absent_coat_pigmentation2.48339420
7MP0008438_abnormal_cutaneous_collagen2.37503542
8MP0002009_preneoplasia2.37474407
9MP0001958_emphysema2.32892866
10MP0005503_abnormal_tendon_morphology2.14911098
11MP0008877_abnormal_DNA_methylation2.13016632
12MP0001188_hyperpigmentation2.07858026
13MP0000383_abnormal_hair_follicle1.95472456
14MP0000013_abnormal_adipose_tissue1.92842223
15MP0003121_genomic_imprinting1.91347498
16MP0004808_abnormal_hematopoietic_stem1.84878806
17MP0001879_abnormal_lymphatic_vessel1.82782429
18MP0005409_darkened_coat_color1.76500461
19MP0010678_abnormal_skin_adnexa1.76431688
20MP0005623_abnormal_meninges_morphology1.70951122
21MP0005076_abnormal_cell_differentiation1.70268874
22MP0005023_abnormal_wound_healing1.68923494
23MP0003385_abnormal_body_wall1.66233545
24MP0003300_gastrointestinal_ulcer1.65035502
25MP0003828_pulmonary_edema1.60770048
26MP0000516_abnormal_urinary_system1.58855197
27MP0005367_renal/urinary_system_phenotyp1.58855197
28MP0008007_abnormal_cellular_replicative1.56421105
29MP0000015_abnormal_ear_pigmentation1.49369341
30MP0002396_abnormal_hematopoietic_system1.46685629
31MP0010368_abnormal_lymphatic_system1.46439089
32MP0010307_abnormal_tumor_latency1.45614889
33MP0000778_abnormal_nervous_system1.45174510
34MP0005275_abnormal_skin_tensile1.44775918
35MP0005248_abnormal_Harderian_gland1.40272776
36MP0001299_abnormal_eye_distance/1.40146933
37MP0003941_abnormal_skin_development1.38209369
38MP0010234_abnormal_vibrissa_follicle1.36194035
39MP0010352_gastrointestinal_tract_polyps1.32471030
40MP0004084_abnormal_cardiac_muscle1.30744717
41MP0008057_abnormal_DNA_replication1.27703372
42MP0004859_abnormal_synaptic_plasticity1.27217680
43MP0002177_abnormal_outer_ear1.27112428
44MP0002166_altered_tumor_susceptibility1.26020601
45MP0000733_abnormal_muscle_development1.22629942
46MP0002006_tumorigenesis1.21221460
47MP0003091_abnormal_cell_migration1.19630247
48MP0000537_abnormal_urethra_morphology1.19446892
49MP0003453_abnormal_keratinocyte_physiol1.17915372
50MP0000428_abnormal_craniofacial_morphol1.15912642
51MP0003890_abnormal_embryonic-extraembry1.14186398
52MP0005174_abnormal_tail_pigmentation1.12329587
53MP0000003_abnormal_adipose_tissue1.12273790
54MP0004134_abnormal_chest_morphology1.12269300
55MP0003937_abnormal_limbs/digits/tail_de1.10915109
56MP0004742_abnormal_vestibular_system1.10876603
57MP0000465_gastrointestinal_hemorrhage1.10442619
58MP0001177_atelectasis1.08187364
59MP0010386_abnormal_urinary_bladder1.07558952
60MP0003191_abnormal_cellular_cholesterol1.07160885
61MP0003755_abnormal_palate_morphology1.07089555
62MP0009780_abnormal_chondrocyte_physiolo1.04089824
63MP0004272_abnormal_basement_membrane1.03961116
64MP0003567_abnormal_fetal_cardiomyocyte1.02402876
65MP0000762_abnormal_tongue_morphology1.02380850
66MP0005621_abnormal_cell_physiology1.02193388
67MP0002998_abnormal_bone_remodeling1.02138463
68MP0001851_eye_inflammation1.01721520
69MP0003705_abnormal_hypodermis_morpholog1.01359024
70MP0005595_abnormal_vascular_smooth1.00534950
71MP0001243_abnormal_dermal_layer0.99859452
72MP0000767_abnormal_smooth_muscle0.99111927
73MP0000432_abnormal_head_morphology0.97412633
74MP0005164_abnormal_response_to0.96701363
75MP0003045_fibrosis0.96303197
76MP0003448_altered_tumor_morphology0.95317712
77MP0001915_intracranial_hemorrhage0.94754280
78MP0009250_abnormal_appendicular_skeleto0.94394818
79* MP0002086_abnormal_extraembryonic_tissu0.94332490
80* MP0002128_abnormal_blood_circulation0.94216695
81MP0003943_abnormal_hepatobiliary_system0.93559998
82MP0006054_spinal_hemorrhage0.93248770
83MP0003279_aneurysm0.91243971
84MP0008260_abnormal_autophagy0.89181111
85MP0004883_abnormal_blood_vessel0.88753424
86* MP0003935_abnormal_craniofacial_develop0.88479685
87MP0003303_peritoneal_inflammation0.87172613
88MP0009384_cardiac_valve_regurgitation0.87052279
89MP0002877_abnormal_melanocyte_morpholog0.84286714
90MP0003115_abnormal_respiratory_system0.84082050
91MP0005197_abnormal_uvea_morphology0.83995009
92MP0002133_abnormal_respiratory_system0.83935138
93MP0005388_respiratory_system_phenotype0.83935138
94MP0010094_abnormal_chromosome_stability0.83817692
95* MP0002925_abnormal_cardiovascular_devel0.83804473
96MP0000534_abnormal_ureter_morphology0.83626687
97MP0001542_abnormal_bone_strength0.83365729
98MP0004484_altered_response_of0.83174483
99MP0002116_abnormal_craniofacial_bone0.82723263
100MP0002295_abnormal_pulmonary_circulatio0.82155008
101MP0002095_abnormal_skin_pigmentation0.79989356
102MP0004185_abnormal_adipocyte_glucose0.79858627
103* MP0001614_abnormal_blood_vessel0.79854115
104MP0009379_abnormal_foot_pigmentation0.78627053
105MP0002108_abnormal_muscle_morphology0.77824873
106MP0003122_maternal_imprinting0.77666584
107MP0005257_abnormal_intraocular_pressure0.76282309
108MP0003942_abnormal_urinary_system0.75742848
109MP0002896_abnormal_bone_mineralization0.75690826
110MP0002088_abnormal_embryonic_growth/wei0.75649125
111MP0003763_abnormal_thymus_physiology0.75100548
112MP0002184_abnormal_innervation0.75043369
113MP0006138_congestive_heart_failure0.74633600
114MP0005508_abnormal_skeleton_morphology0.74631358
115MP0009703_decreased_birth_body0.73581402
116MP0003861_abnormal_nervous_system0.73529293
117MP0002109_abnormal_limb_morphology0.73262190
118MP0003984_embryonic_growth_retardation0.72959466
119MP0002735_abnormal_chemical_nociception0.72614506
120MP0002081_perinatal_lethality0.72471992
121MP0003077_abnormal_cell_cycle0.72182735
122MP0001216_abnormal_epidermal_layer0.72095060
123MP0000462_abnormal_digestive_system0.71822922
124MP0000427_abnormal_hair_cycle0.71760632
125MP0002092_abnormal_eye_morphology0.71630310
126* MP0002084_abnormal_developmental_patter0.71179629
127MP0002089_abnormal_postnatal_growth/wei0.70548475
128MP0003123_paternal_imprinting0.70268774
129MP0000647_abnormal_sebaceous_gland0.70208299
130MP0001191_abnormal_skin_condition0.70203193
131MP0000751_myopathy0.69692181
132MP0002113_abnormal_skeleton_development0.68843848
133MP0006292_abnormal_olfactory_placode0.68617281
134MP0002102_abnormal_ear_morphology0.67578429
135MP0002060_abnormal_skin_morphology0.66926527
136MP0001784_abnormal_fluid_regulation0.65991312
137MP0005384_cellular_phenotype0.64717398
138MP0002277_abnormal_respiratory_mucosa0.64001420
139MP0000703_abnormal_thymus_morphology0.63447200
140MP0002115_abnormal_skeleton_extremities0.63122038
141MP0002168_other_aberrant_phenotype0.62804720

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.86089941
2Subacute progressive viral hepatitis (HP:0006572)3.26118525
3Syringomyelia (HP:0003396)3.12404588
4Spinal cord lesions (HP:0100561)3.12404588
5Vertebral arch anomaly (HP:0008438)2.81989569
6Inappropriate behavior (HP:0000719)2.68348852
7Absent frontal sinuses (HP:0002688)2.68164973
8Prostate neoplasm (HP:0100787)2.62126045
9Exotropia (HP:0000577)2.59647623
10Hematochezia (HP:0002573)2.52359008
11Heterotopia (HP:0002282)2.43077497
12Follicular hyperkeratosis (HP:0007502)2.43019353
13Disinhibition (HP:0000734)2.42409118
14Papillary thyroid carcinoma (HP:0002895)2.37720110
15Asymmetry of the thorax (HP:0001555)2.35017957
16Shallow orbits (HP:0000586)2.33666308
17Arterial tortuosity (HP:0005116)2.29564764
18Premature rupture of membranes (HP:0001788)2.29464811
19Abnormality of the nasal septum (HP:0000419)2.29310770
20Abnormality of the fingertips (HP:0001211)2.27700971
21Cerebral aneurysm (HP:0004944)2.26796614
22Ankle contracture (HP:0006466)2.25329649
23Vascular tortuosity (HP:0004948)2.21323771
24Aortic aneurysm (HP:0004942)2.18108200
25Aortic dissection (HP:0002647)2.16998355
26Drooling (HP:0002307)2.15541066
27Excessive salivation (HP:0003781)2.15541066
28Short 4th metacarpal (HP:0010044)2.14117403
29Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14117403
30Milia (HP:0001056)2.14044119
31Aortic regurgitation (HP:0001659)2.12224946
32Aplasia cutis congenita (HP:0001057)2.11221663
33Aqueductal stenosis (HP:0002410)2.08847003
34Pulmonic stenosis (HP:0001642)2.07779522
35Abnormality of the lower motor neuron (HP:0002366)2.05830873
36Fragile skin (HP:0001030)2.02982909
37Stomach cancer (HP:0012126)1.98274015
38Neoplasm of the tracheobronchial system (HP:0100552)1.95972224
39Distal upper limb amyotrophy (HP:0007149)1.95845256
40Upper limb amyotrophy (HP:0009129)1.95845256
41Amyotrophic lateral sclerosis (HP:0007354)1.94922967
42Limb-girdle muscle weakness (HP:0003325)1.94726518
43Urethral obstruction (HP:0000796)1.94283967
44Wrist flexion contracture (HP:0001239)1.94018431
45Thick eyebrow (HP:0000574)1.93829603
46Transitional cell carcinoma of the bladder (HP:0006740)1.92706767
47Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.91463411
48Neonatal short-limb short stature (HP:0008921)1.91379942
49Mitral stenosis (HP:0001718)1.90739199
50Lower limb amyotrophy (HP:0007210)1.90522798
51Short nail (HP:0001799)1.89859724
52Absent speech (HP:0001344)1.89489987
53Macroorchidism (HP:0000053)1.88453134
54Abnormality of the right ventricle (HP:0001707)1.88250507
55Hand muscle atrophy (HP:0009130)1.88158252
56Ankyloglossia (HP:0010296)1.87418176
57Aneurysm (HP:0002617)1.85460048
58Broad face (HP:0000283)1.85337185
59Viral hepatitis (HP:0006562)1.85230388
60Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.84698937
61Bladder diverticulum (HP:0000015)1.84496111
62Protrusio acetabuli (HP:0003179)1.84431418
63Increased density of long bones (HP:0006392)1.84333370
64Cubitus valgus (HP:0002967)1.84276178
65Mitral valve prolapse (HP:0001634)1.83228320
66Relative macrocephaly (HP:0004482)1.82956972
67Joint laxity (HP:0001388)1.82872995
68Protruding tongue (HP:0010808)1.81272110
69Abnormality of the frontal sinuses (HP:0002687)1.80768561
70Acute myeloid leukemia (HP:0004808)1.80315008
71Deep philtrum (HP:0002002)1.80205255
72Overgrowth (HP:0001548)1.80167535
73Widely spaced teeth (HP:0000687)1.79591976
74Mild short stature (HP:0003502)1.78804681
75Fair hair (HP:0002286)1.78753198
76Spinal rigidity (HP:0003306)1.77993325
77Large earlobe (HP:0009748)1.77502195
78Curly hair (HP:0002212)1.77058613
79Bladder neoplasm (HP:0009725)1.76337546
80Bladder carcinoma (HP:0002862)1.76337546
81Palpebral edema (HP:0100540)1.75890242
82Mesomelia (HP:0003027)1.75597508
83Narrow palate (HP:0000189)1.75458534
84Midline defect of the nose (HP:0004122)1.75194328
85Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.74870578
86Thyroid carcinoma (HP:0002890)1.74512512
87Microglossia (HP:0000171)1.72954000
88Facial hemangioma (HP:0000329)1.71607987
89Morphological abnormality of the middle ear (HP:0008609)1.69995267
90Skull defect (HP:0001362)1.69991655
91Broad metatarsal (HP:0001783)1.69526650
92Truncal obesity (HP:0001956)1.67530419
93Soft skin (HP:0000977)1.67309071
94Distal lower limb amyotrophy (HP:0008944)1.67093671
95Insidious onset (HP:0003587)1.66133716
96Termporal pattern (HP:0011008)1.66133716
97Mitral regurgitation (HP:0001653)1.65194822
98Dislocated radial head (HP:0003083)1.64500494
99Pelvic girdle muscle weakness (HP:0003749)1.64448150
100Hypoplasia of the iris (HP:0007676)1.64443667
101Heterochromia iridis (HP:0001100)1.63683722
102Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.63299328
103Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.63223471
104Hypoplasia of the maxilla (HP:0000327)1.62312220
105Lower limb muscle weakness (HP:0007340)1.61729580
106Cervical subluxation (HP:0003308)1.61445423
107Enlarged penis (HP:0000040)1.61228320
108Spondylolisthesis (HP:0003302)1.60325074
109Spinal muscular atrophy (HP:0007269)1.60294574
110Arnold-Chiari malformation (HP:0002308)1.59095080
111Genu recurvatum (HP:0002816)1.58647791
112High pitched voice (HP:0001620)1.58462995
113Abnormality of the musculature of the pelvis (HP:0001469)1.57945738
114Abnormality of the hip-girdle musculature (HP:0001445)1.57945738
115Atrophic scars (HP:0001075)1.57894642
116Abnormality of the radial head (HP:0003995)1.57658935
117Cutaneous finger syndactyly (HP:0010554)1.57650819
118Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.57218487
119Cystic hygroma (HP:0000476)1.56626371
120Hoarse voice (HP:0001609)1.56510410
121Alveolar cell carcinoma (HP:0006519)1.56458279
122Increased number of teeth (HP:0011069)1.56172925
123Bowel diverticulosis (HP:0005222)1.56133858
124Thyroiditis (HP:0100646)1.56097203
125Abnormality of chromosome stability (HP:0003220)1.55730545
126Rectal prolapse (HP:0002035)1.55613274
127Absent eyebrow (HP:0002223)1.55502571
128Long eyelashes (HP:0000527)1.55496255
129Hyperextensible skin (HP:0000974)1.55189771
130Decreased skull ossification (HP:0004331)1.54956025
131Supernumerary ribs (HP:0005815)1.54900728
132Broad ribs (HP:0000885)1.54854154
133Dilatation of the ascending aorta (HP:0005111)1.54441643
134Wormian bones (HP:0002645)1.54233557
135Abnormality of salivation (HP:0100755)1.53040303
136Abnormality of the corticospinal tract (HP:0002492)1.52744723
137Shoulder girdle muscle weakness (HP:0003547)1.52564525
138Deviation of the thumb (HP:0009603)1.52138660
139Nephronophthisis (HP:0000090)1.51513254
140Generalized hypopigmentation of hair (HP:0011358)1.50584200
141Osteolytic defects of the hand bones (HP:0009699)1.50241568
142Osteolytic defects of the phalanges of the hand (HP:0009771)1.50241568
143Conjunctival telangiectasia (HP:0000524)1.49747383
144Tibial bowing (HP:0002982)1.49611886
145Limited hip movement (HP:0008800)1.49549815
146Blue sclerae (HP:0000592)1.49381737
147Submucous cleft hard palate (HP:0000176)1.49331694
148Abnormality of dentin (HP:0010299)1.49181617
149Buphthalmos (HP:0000557)1.48826955
150Cardiovascular calcification (HP:0011915)1.48462772
151Abnormal auditory evoked potentials (HP:0006958)1.47769921
152Abnormality of oral frenula (HP:0000190)1.47604127
153Disproportionate tall stature (HP:0001519)1.47208319
154Proximal placement of thumb (HP:0009623)1.46552726
155Uterine leiomyosarcoma (HP:0002891)1.46093795
156Leiomyosarcoma (HP:0100243)1.46093795
157Malignant gastrointestinal tract tumors (HP:0006749)1.45369300
158Gastrointestinal carcinoma (HP:0002672)1.45369300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.89832806
2ERBB33.14668641
3AKT33.11429807
4NUAK13.10437741
5MET3.02557350
6MST1R2.53998015
7CDC72.41436503
8EPHA32.30929444
9MARK12.29340521
10* PDGFRA2.19140413
11LMTK22.18112340
12PLK22.16960138
13FRK2.16625964
14BCR2.15523480
15WNK12.05202452
16CDK82.03408032
17BMPR1B2.00631337
18PTK21.87215446
19NTRK11.69671793
20CAMK1G1.64329645
21TGFBR21.62882079
22STK381.59765690
23BRD41.57400755
24GRK71.56646576
25MAP3K61.53187002
26MKNK11.44800260
27STK31.44708959
28NTRK31.43778983
29TRPM71.41437563
30TXK1.41262244
31SIK21.39505793
32FER1.38637675
33TGFBR11.38397331
34KSR11.37178836
35FGFR31.35530432
36CASK1.32643668
37NEK91.30917213
38CDK61.26525958
39PNCK1.24539923
40BRSK21.22928274
41ERBB41.21116132
42MAPK131.20939642
43CDK121.20110481
44MKNK21.17073695
45PRPF4B1.16678192
46CAMK1D1.15632698
47CAMKK21.12504772
48CDK91.12371655
49YES11.12198790
50EIF2AK21.09317723
51CSNK1A1L1.09119955
52BMPR21.06601138
53RIPK41.05839421
54IRAK41.04897234
55SGK21.04536136
56MOS1.02621647
57MINK11.00301904
58MAP3K40.97958293
59MAP3K140.97609950
60MELK0.96312861
61LATS20.94008049
62CSNK1G20.91938012
63KSR20.90450282
64ATM0.90395798
65TYK20.88955764
66ROCK20.88639078
67MAP3K100.87710576
68MAP3K20.87459113
69RIPK10.87132088
70ACVR1B0.85617930
71EIF2AK30.84693962
72CHUK0.84624632
73DMPK0.84608039
74PIK3CA0.82893329
75SCYL20.82721901
76PLK30.82540166
77ICK0.80764472
78RAF10.80534832
79PTK2B0.80516038
80FES0.80473943
81PAK20.78590609
82CDC42BPA0.78396004
83PIK3CG0.77649249
84PLK40.76736798
85JAK30.76050641
86DDR20.72507588
87CDK30.71883544
88EPHA20.70451758
89ROCK10.70272995
90MAPK70.69785080
91SRPK10.68924242
92CSNK1G10.66338873
93NEK60.65936380
94MTOR0.65909843
95EPHA40.65392087
96ZAK0.63520054
97JAK10.63109502
98MAP3K50.62555717
99PKN20.61998346
100HCK0.60263764
101MAP3K130.59962995
102PRKD20.59509597
103BMX0.59034736
104NEK10.58661064
105EPHB20.58650993
106ATR0.57784075
107MYLK0.57715204
108PAK40.55939465
109DAPK20.54045069
110SGK30.54038354
111CAMKK10.53515032
112FGFR10.53131532
113TTN0.53115658
114* PDGFRB0.52483082
115ABL10.51985224
116CCNB10.51050031
117MAP2K70.50940613
118MAPK100.50176699
119PRKG10.49938155
120STK240.49932123
121DYRK1A0.49852240
122PRKG20.49827750
123PRKCQ0.49525773
124TEC0.48355227
125CSNK1G30.48160630
126RET0.47260698
127INSR0.47098827
128* EGFR0.46896679
129FLT30.46017641
130PRKCH0.45726049
131NLK0.45256145
132TRIM280.45136862
133CHEK20.44374584
134TTK0.43381693
135PAK30.42761146
136IGF1R0.42690336
137SGK10.42289722
138STK390.42271165
139STK100.41702323
140MAP3K90.41385944
141NTRK20.41342739
142RPS6KA20.41157401
143CHEK10.40108690
144NEK20.39976736
145MAP2K40.39232920
146MAPK80.38350163
147MAP2K10.38297715
148MAP3K70.37925043
149CSNK1D0.37527077
150STK38L0.37401435
151PAK60.37138243
152PRKDC0.36996773
153FGFR20.35844210
154KDR0.35786431

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.70597208
2MicroRNAs in cancer_Homo sapiens_hsa052061.49075172
3Long-term potentiation_Homo sapiens_hsa047201.45080238
4Adherens junction_Homo sapiens_hsa045201.42865356
5Pancreatic cancer_Homo sapiens_hsa052121.36010155
6Dorso-ventral axis formation_Homo sapiens_hsa043201.30419166
7Colorectal cancer_Homo sapiens_hsa052101.29764801
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24183529
9Glioma_Homo sapiens_hsa052141.23678140
10Endometrial cancer_Homo sapiens_hsa052131.22070615
11* Axon guidance_Homo sapiens_hsa043601.21075744
12Amoebiasis_Homo sapiens_hsa051461.19777425
13Focal adhesion_Homo sapiens_hsa045101.19774864
14Inositol phosphate metabolism_Homo sapiens_hsa005621.19353637
15Chronic myeloid leukemia_Homo sapiens_hsa052201.18975110
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17805888
17Prostate cancer_Homo sapiens_hsa052151.15146432
18B cell receptor signaling pathway_Homo sapiens_hsa046621.14633850
19Gap junction_Homo sapiens_hsa045401.11212327
20T cell receptor signaling pathway_Homo sapiens_hsa046601.10420334
21Viral myocarditis_Homo sapiens_hsa054161.09562741
22Cell cycle_Homo sapiens_hsa041101.09496023
23Osteoclast differentiation_Homo sapiens_hsa043801.09271192
24TGF-beta signaling pathway_Homo sapiens_hsa043501.08514014
25Renin secretion_Homo sapiens_hsa049241.07752512
26Ovarian steroidogenesis_Homo sapiens_hsa049131.07152588
27ECM-receptor interaction_Homo sapiens_hsa045121.06950942
28Long-term depression_Homo sapiens_hsa047301.06441454
29Proteoglycans in cancer_Homo sapiens_hsa052051.06087158
30Toxoplasmosis_Homo sapiens_hsa051451.04336591
31Circadian rhythm_Homo sapiens_hsa047101.04248102
32Platelet activation_Homo sapiens_hsa046111.04160704
33ErbB signaling pathway_Homo sapiens_hsa040121.04143700
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02670003
35Glutamatergic synapse_Homo sapiens_hsa047241.02108747
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00990507
37mTOR signaling pathway_Homo sapiens_hsa041501.00730468
38Phospholipase D signaling pathway_Homo sapiens_hsa040720.99384421
39Sphingolipid signaling pathway_Homo sapiens_hsa040710.98890379
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98160011
41Wnt signaling pathway_Homo sapiens_hsa043100.97861232
42mRNA surveillance pathway_Homo sapiens_hsa030150.97461671
43Measles_Homo sapiens_hsa051620.97130462
44Small cell lung cancer_Homo sapiens_hsa052220.96425798
45Hepatitis B_Homo sapiens_hsa051610.96182502
46Serotonergic synapse_Homo sapiens_hsa047260.95244571
47Shigellosis_Homo sapiens_hsa051310.94899578
48Renal cell carcinoma_Homo sapiens_hsa052110.94853225
49Oocyte meiosis_Homo sapiens_hsa041140.94211484
50Nicotine addiction_Homo sapiens_hsa050330.94103906
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93479131
52Acute myeloid leukemia_Homo sapiens_hsa052210.93379120
53Choline metabolism in cancer_Homo sapiens_hsa052310.93258113
54Amphetamine addiction_Homo sapiens_hsa050310.92388589
55Leishmaniasis_Homo sapiens_hsa051400.90108507
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90073617
57FoxO signaling pathway_Homo sapiens_hsa040680.89939893
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89860049
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.89681258
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89287690
61HTLV-I infection_Homo sapiens_hsa051660.89171516
62Oxytocin signaling pathway_Homo sapiens_hsa049210.89033115
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88545818
64Non-small cell lung cancer_Homo sapiens_hsa052230.88281430
65GnRH signaling pathway_Homo sapiens_hsa049120.88096569
66Dopaminergic synapse_Homo sapiens_hsa047280.88095956
67Chemokine signaling pathway_Homo sapiens_hsa040620.87972325
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87504994
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87251415
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.87091261
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.86758843
72Olfactory transduction_Homo sapiens_hsa047400.86353369
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84979887
74Non-homologous end-joining_Homo sapiens_hsa034500.84929213
75Circadian entrainment_Homo sapiens_hsa047130.83633649
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83323264
77* MAPK signaling pathway_Homo sapiens_hsa040100.83148147
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83147339
79Melanoma_Homo sapiens_hsa052180.82986792
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82796737
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82728989
82Prolactin signaling pathway_Homo sapiens_hsa049170.82135119
83VEGF signaling pathway_Homo sapiens_hsa043700.82030272
84Rap1 signaling pathway_Homo sapiens_hsa040150.81634966
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79966505
86p53 signaling pathway_Homo sapiens_hsa041150.79822535
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79753595
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79487132
89Hippo signaling pathway_Homo sapiens_hsa043900.79312873
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.78968836
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78858439
92Bladder cancer_Homo sapiens_hsa052190.78857758
93Melanogenesis_Homo sapiens_hsa049160.77080558
94Pathways in cancer_Homo sapiens_hsa052000.76813305
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76610044
96Morphine addiction_Homo sapiens_hsa050320.76451051
97Tight junction_Homo sapiens_hsa045300.75498705
98Thyroid cancer_Homo sapiens_hsa052160.73839030
99TNF signaling pathway_Homo sapiens_hsa046680.73826851
100* Ras signaling pathway_Homo sapiens_hsa040140.73739437
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73450013
102Salmonella infection_Homo sapiens_hsa051320.73103636
103Estrogen signaling pathway_Homo sapiens_hsa049150.72903066
104Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72641976
105Fanconi anemia pathway_Homo sapiens_hsa034600.72441100
106Herpes simplex infection_Homo sapiens_hsa051680.72421213
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72271353
108Cholinergic synapse_Homo sapiens_hsa047250.71705050
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70912449
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.70659272
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69842239
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69602642
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69186108
114Dilated cardiomyopathy_Homo sapiens_hsa054140.67538933
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66654509
116cAMP signaling pathway_Homo sapiens_hsa040240.66611110
117Tuberculosis_Homo sapiens_hsa051520.66358096
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66249988
119Taste transduction_Homo sapiens_hsa047420.65871298
120Endocytosis_Homo sapiens_hsa041440.65849304
121Salivary secretion_Homo sapiens_hsa049700.63058911
122Thyroid hormone synthesis_Homo sapiens_hsa049180.62314450
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.60554491
124Type II diabetes mellitus_Homo sapiens_hsa049300.58927087
125Insulin signaling pathway_Homo sapiens_hsa049100.57080438
126HIF-1 signaling pathway_Homo sapiens_hsa040660.54907792

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