RASA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)5.79801422
2regulation of gamma-delta T cell differentiation (GO:0045586)5.24870987
3regulation of gamma-delta T cell activation (GO:0046643)5.04363109
4positive T cell selection (GO:0043368)4.97324012
5positive thymic T cell selection (GO:0045059)4.57489731
6activated T cell proliferation (GO:0050798)4.52484598
7negative regulation of T cell mediated immunity (GO:0002710)4.45107416
8NIK/NF-kappaB signaling (GO:0038061)4.23498419
9negative regulation of lymphocyte mediated immunity (GO:0002707)4.11611764
10tolerance induction (GO:0002507)4.06891791
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.96930413
12cellular extravasation (GO:0045123)3.94726891
13B cell receptor signaling pathway (GO:0050853)3.91593560
14regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.78291999
15regulation of B cell differentiation (GO:0045577)3.67733031
16mitotic sister chromatid cohesion (GO:0007064)3.58631276
17regulation of RIG-I signaling pathway (GO:0039535)3.57212421
18negative regulation of leukocyte mediated immunity (GO:0002704)3.49022370
19tyrosine phosphorylation of STAT protein (GO:0007260)3.47825126
20regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.45740230
21regulation of isotype switching to IgG isotypes (GO:0048302)3.43636594
22positive regulation of B cell differentiation (GO:0045579)3.42848445
23positive regulation by symbiont of host defense response (GO:0052509)3.41690751
24modulation by symbiont of host defense response (GO:0052031)3.41690751
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.41690751
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.41690751
27positive regulation by organism of defense response of other organism involved in symbiotic interact3.41690751
28modulation by symbiont of host immune response (GO:0052553)3.41690751
29negative regulation of interleukin-12 production (GO:0032695)3.41644948
30positive regulation of tolerance induction (GO:0002645)3.41638712
31negative T cell selection (GO:0043383)3.40992866
32mast cell activation (GO:0045576)3.40727571
33negative thymic T cell selection (GO:0045060)3.39893804
34CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.37347648
35T-helper cell differentiation (GO:0042093)3.37347648
36negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.36854063
37negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.36697939
38myoblast migration (GO:0051451)3.31889738
39negative regulation of T-helper cell differentiation (GO:0045623)3.31120467
40negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.31120467
41phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.30049131
42regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.29919798
43antigen receptor-mediated signaling pathway (GO:0050851)3.26576908
44detection of other organism (GO:0098543)3.25971000
45T cell receptor signaling pathway (GO:0050852)3.25883408
46regulation of tolerance induction (GO:0002643)3.25587022
47negative regulation of adaptive immune response (GO:0002820)3.22542926
48regulation of interleukin-12 biosynthetic process (GO:0045075)3.21286938
49response to muramyl dipeptide (GO:0032495)3.14582476
50regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.14203591
51regulation of natural killer cell mediated immunity (GO:0002715)3.14203591
52positive regulation of T cell differentiation in thymus (GO:0033089)3.11951345
53regulation of memory T cell differentiation (GO:0043380)3.09773458
54cellular response to interleukin-15 (GO:0071350)3.08796628
55regulation of T cell mediated cytotoxicity (GO:0001914)3.08362308
56neutrophil mediated immunity (GO:0002446)3.08264501
57detection of molecule of bacterial origin (GO:0032490)3.07308930
58macrophage activation involved in immune response (GO:0002281)3.05154128
59neutrophil activation involved in immune response (GO:0002283)3.04998995
60myeloid dendritic cell differentiation (GO:0043011)3.02225745
61myeloid leukocyte mediated immunity (GO:0002444)3.00211757
62positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.00143507
63T cell proliferation (GO:0042098)2.97197938
64detection of bacterium (GO:0016045)2.96642694
65positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.95798914
66T cell differentiation involved in immune response (GO:0002292)2.95711642
67alpha-beta T cell differentiation involved in immune response (GO:0002293)2.95711642
68alpha-beta T cell activation involved in immune response (GO:0002287)2.95711642
69myeloid dendritic cell activation (GO:0001773)2.95672968
70regulation of interferon-beta biosynthetic process (GO:0045357)2.93480685
71microglial cell activation (GO:0001774)2.93443216
72regulation of activation of Janus kinase activity (GO:0010533)2.92926971
73positive regulation of T cell mediated cytotoxicity (GO:0001916)2.91782431
74regulation of leukocyte mediated cytotoxicity (GO:0001910)2.91627477
75myeloid cell activation involved in immune response (GO:0002275)2.91081076
76regulation of alpha-beta T cell proliferation (GO:0046640)2.90951285
77B cell homeostasis (GO:0001782)2.89920485
78interferon-gamma secretion (GO:0072643)2.88815893
79type I interferon signaling pathway (GO:0060337)2.88732234
80cellular response to type I interferon (GO:0071357)2.88732234
81detection of external biotic stimulus (GO:0098581)2.87921766
82positive regulation of alpha-beta T cell proliferation (GO:0046641)2.87197574
83regulation of T-helper 1 cell differentiation (GO:0045625)2.87178089
84T cell differentiation (GO:0030217)2.87092722
85interferon-gamma production (GO:0032609)2.86958132
86response to type I interferon (GO:0034340)2.85339291
87natural killer cell differentiation (GO:0001779)2.84216024
88Peyers patch development (GO:0048541)2.81504506
89mucosal-associated lymphoid tissue development (GO:0048537)2.81504506
90negative regulation of cell killing (GO:0031342)2.81118840
91negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81118840
92sister chromatid cohesion (GO:0007062)2.80838619
93dendritic cell migration (GO:0036336)2.80558886
94hepatocyte apoptotic process (GO:0097284)2.80494017
95antigen processing and presentation via MHC class Ib (GO:0002475)2.79923518
96regulation of interleukin-2 biosynthetic process (GO:0045076)2.79729978
97T cell migration (GO:0072678)2.76082096
98kinetochore assembly (GO:0051382)2.72058711
99regulation of germinal center formation (GO:0002634)2.71610877
100DNA strand renaturation (GO:0000733)2.70939642
101meiotic chromosome segregation (GO:0045132)2.69187717
102response to interleukin-15 (GO:0070672)2.67176420
103natural killer cell mediated cytotoxicity (GO:0042267)2.66028830
104natural killer cell mediated immunity (GO:0002228)2.66028830
105positive regulation of heat generation (GO:0031652)2.62603333
106DNA damage induced protein phosphorylation (GO:0006975)2.60788153
107regulation of establishment of cell polarity (GO:2000114)2.59800803
108positive regulation of interleukin-12 production (GO:0032735)2.58110069
109growth hormone receptor signaling pathway (GO:0060396)2.56892842
110histone H3-K4 trimethylation (GO:0080182)2.55379840
111regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.53809701
112CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.53376451
113positive regulation of granulocyte differentiation (GO:0030854)2.53165775
114monoubiquitinated protein deubiquitination (GO:0035520)2.52957703
115kinetochore organization (GO:0051383)2.52783694
116regulation of histone H3-K27 methylation (GO:0061085)2.52474214
117regulation of fibroblast apoptotic process (GO:2000269)2.52011156
118histone H3-K36 demethylation (GO:0070544)2.50390371
119cytoplasmic mRNA processing body assembly (GO:0033962)2.48820840
120positive regulation of interleukin-2 production (GO:0032743)2.48092875
121positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.47204573
122positive regulation of gamma-delta T cell activation (GO:0046645)2.46858688
123female gamete generation (GO:0007292)2.46601082
124positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.46245908
125regulation of T cell tolerance induction (GO:0002664)2.46177983
126T cell selection (GO:0045058)2.45382399
127leukocyte aggregation (GO:0070486)2.45185007
128positive regulation of T-helper cell differentiation (GO:0045624)2.43428709
129positive regulation of cellular amide metabolic process (GO:0034250)2.43166776
130negative regulation of hormone biosynthetic process (GO:0032353)2.42897079
131negative regulation of hormone metabolic process (GO:0032351)2.42897079
132interferon-gamma-mediated signaling pathway (GO:0060333)2.42562107
133neutrophil activation (GO:0042119)2.41511296
134antigen processing and presentation of endogenous antigen (GO:0019883)2.41397216
135positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.39035912
136CD4-positive, alpha-beta T cell activation (GO:0035710)2.38878383
137T cell lineage commitment (GO:0002360)2.38091318
138positive regulation of interleukin-17 production (GO:0032740)2.37307501
139thymic T cell selection (GO:0045061)2.36752414
140germinal center formation (GO:0002467)2.36419276
141negative regulation of homotypic cell-cell adhesion (GO:0034111)2.35981044
142positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.33233248
143presynaptic membrane assembly (GO:0097105)2.32573285
144alpha-beta T cell activation (GO:0046631)2.31074282
145negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.29985235
146piRNA metabolic process (GO:0034587)2.29788997
147mesenchymal cell differentiation involved in renal system development (GO:2001012)2.28779232
148mesenchymal cell differentiation involved in kidney development (GO:0072161)2.28779232
149regulation of T-helper cell differentiation (GO:0045622)2.28494103
150histone lysine demethylation (GO:0070076)2.28225033
151replication fork processing (GO:0031297)2.27339985
152regulation of T cell receptor signaling pathway (GO:0050856)2.27290119
153regulation of meiosis I (GO:0060631)2.26274734
154T cell activation involved in immune response (GO:0002286)2.26083631
155regulation of fever generation (GO:0031620)2.25639031
156alpha-beta T cell differentiation (GO:0046632)2.24700024
157regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.24121142
158antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.23330046
159antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.23330046
160positive regulation of T-helper 1 type immune response (GO:0002827)2.23273520
161natural killer cell activation (GO:0030101)2.21861203
162granulocyte activation (GO:0036230)2.20940486
163regulation of regulatory T cell differentiation (GO:0045589)2.19623536
164maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.19286858
165negative regulation of alcohol biosynthetic process (GO:1902931)2.19220023
166regulation of hypersensitivity (GO:0002883)2.17987113
167regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.16357247
168cellular response to growth hormone stimulus (GO:0071378)2.15937672

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* SMAD_19615063_ChIP-ChIP_OVARY_Human4.68115950
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.96967241
3* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.26363341
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.98180927
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.57924817
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.54121556
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.52984750
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.51565348
9* MYB_26560356_Chip-Seq_TH1_Human2.38281309
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30312147
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26996134
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26863018
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.16989553
14* GATA3_27048872_Chip-Seq_THYMUS_Human2.15959319
15* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.15282051
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.09474560
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.06780050
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.02849574
19SPI1_23547873_ChIP-Seq_NB4_Human1.96740259
20IRF8_21731497_ChIP-ChIP_J774_Mouse1.92917862
21RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.91246300
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90075114
23IGF1R_20145208_ChIP-Seq_DFB_Human1.87618416
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84319978
25* MAF_26560356_Chip-Seq_TH1_Human1.83816656
26NANOG_18555785_Chip-Seq_ESCs_Mouse1.83790657
27* SCL_19346495_ChIP-Seq_HPC-7_Human1.82120415
28GATA3_26560356_Chip-Seq_TH2_Human1.78787248
29TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.78058869
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71475828
31RUNX_20019798_ChIP-Seq_JUKART_Human1.70324053
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.69755288
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.69267605
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69267605
35FUS_26573619_Chip-Seq_HEK293_Human1.69224188
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66769977
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.66532730
38P300_19829295_ChIP-Seq_ESCs_Human1.63622686
39E2F7_22180533_ChIP-Seq_HELA_Human1.62107139
40EWS_26573619_Chip-Seq_HEK293_Human1.61783108
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59076774
42E2F1_18555785_Chip-Seq_ESCs_Mouse1.58677445
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.58596835
44UTX_26944678_Chip-Seq_JUKART_Human1.56060650
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.54442952
46AR_21572438_ChIP-Seq_LNCaP_Human1.54301466
47TP53_16413492_ChIP-PET_HCT116_Human1.51913921
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49255014
49GBX2_23144817_ChIP-Seq_PC3_Human1.48419948
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47457700
51P53_22387025_ChIP-Seq_ESCs_Mouse1.46342142
52SUZ12_18555785_Chip-Seq_ESCs_Mouse1.45998372
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45597843
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.45338347
55VDR_24787735_ChIP-Seq_THP-1_Human1.44205416
56SMAD4_21799915_ChIP-Seq_A2780_Human1.44147823
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43550391
58CMYC_18555785_Chip-Seq_ESCs_Mouse1.43096906
59SPI1_23127762_ChIP-Seq_K562_Human1.42573397
60* RUNX1_22412390_ChIP-Seq_EML_Mouse1.42023753
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.41199263
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.40387555
63STAT3_18555785_Chip-Seq_ESCs_Mouse1.39553347
64PU_27001747_Chip-Seq_BMDM_Mouse1.39452956
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38173312
66NMYC_18555785_Chip-Seq_ESCs_Mouse1.37886127
67* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37724281
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.37682333
69* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36516029
70VDR_24763502_ChIP-Seq_THP-1_Human1.36094729
71TP53_18474530_ChIP-ChIP_U2OS_Human1.34352972
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34246899
73* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33724785
74IRF8_27001747_Chip-Seq_BMDM_Mouse1.33638756
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32640086
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32442469
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31597766
78BP1_19119308_ChIP-ChIP_Hs578T_Human1.31225568
79EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.30833813
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28477382
81* STAT3_23295773_ChIP-Seq_U87_Human1.28003287
82TAF15_26573619_Chip-Seq_HEK293_Human1.27917626
83* MYB_26560356_Chip-Seq_TH2_Human1.27222473
84SOX2_18555785_Chip-Seq_ESCs_Mouse1.27198865
85GATA1_22025678_ChIP-Seq_K562_Human1.26760042
86AR_25329375_ChIP-Seq_VCAP_Human1.25760295
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25615991
88ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24354658
89SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23082837
90MAF_26560356_Chip-Seq_TH2_Human1.23081980
91RXR_22108803_ChIP-Seq_LS180_Human1.23046531
92OCT4_18555785_Chip-Seq_ESCs_Mouse1.23005391
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.22790238
94RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21452504
95RNF2_27304074_Chip-Seq_NSC_Mouse1.20268131
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.20137017
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19431422
98EGR1_19374776_ChIP-ChIP_THP-1_Human1.18296822
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17900550
100TP63_19390658_ChIP-ChIP_HaCaT_Human1.17303850
101P300_18555785_Chip-Seq_ESCs_Mouse1.15930581
102MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14852133
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14473132
104ZFX_18555785_Chip-Seq_ESCs_Mouse1.13875885
105CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10837503
106PU1_27457419_Chip-Seq_LIVER_Mouse1.10632021
107CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09525694
108STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09054054
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08035269
110* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07793833
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07013548
112KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06728610
113CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06604135
114SMRT_27268052_Chip-Seq_Bcells_Human1.05837862
115MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05343356
116* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02142590
117KLF4_18555785_Chip-Seq_ESCs_Mouse1.01506715
118* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00922744
119* TCF4_23295773_ChIP-Seq_U87_Human1.00651195
120ESRRB_18555785_Chip-Seq_ESCs_Mouse1.00386344
121ER_23166858_ChIP-Seq_MCF-7_Human1.00338607
122MYC_22102868_ChIP-Seq_BL_Human0.99442624
123BCAT_22108803_ChIP-Seq_LS180_Human0.99202279
124OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98566681
125TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98491252
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98403701
127CDX2_22108803_ChIP-Seq_LS180_Human0.98331543
128RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98022692
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97466836
130LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96825681
131CTCF_18555785_Chip-Seq_ESCs_Mouse0.96557994
132GATA2_21666600_ChIP-Seq_HMVEC_Human0.94516045
133PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94496368
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94317583
135TCF7_22412390_ChIP-Seq_EML_Mouse0.93383185
136LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92391989
137* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92341303
138GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88727449
139SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87293285
140CRX_20693478_ChIP-Seq_RETINA_Mouse0.87282459
141FOXO3_23340844_ChIP-Seq_DLD1_Human0.85969386
142* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85659563
143LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84274834
144VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79432052
145FLI1_21867929_ChIP-Seq_TH2_Mouse0.78426718
146RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77175365
147GATA3_26560356_Chip-Seq_TH1_Human0.76396319
148SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.75459661
149TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.74123748
150CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73590693
151STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.70722669
152CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.69481494

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation2.94590169
2MP0002009_preneoplasia2.69674576
3MP0002006_tumorigenesis2.68128021
4MP0001986_abnormal_taste_sensitivity2.50476205
5MP0005387_immune_system_phenotype2.46876314
6MP0001790_abnormal_immune_system2.46876314
7MP0005671_abnormal_response_to2.45093081
8MP0003763_abnormal_thymus_physiology2.43372056
9MP0002163_abnormal_gland_morphology2.35364680
10MP0002166_altered_tumor_susceptibility2.15536815
11MP0005310_abnormal_salivary_gland2.12475360
12MP0000685_abnormal_immune_system2.11582403
13MP0004510_myositis2.07822776
14MP0006082_CNS_inflammation2.02324293
15MP0003787_abnormal_imprinting2.00282626
16MP0005000_abnormal_immune_tolerance1.94203644
17MP0001800_abnormal_humoral_immune1.94122308
18MP0002148_abnormal_hypersensitivity_rea1.92846136
19MP0000465_gastrointestinal_hemorrhage1.86799690
20MP0005423_abnormal_somatic_nervous1.86490393
21MP0002452_abnormal_antigen_presenting1.81604618
22MP0008057_abnormal_DNA_replication1.80314008
23MP0001346_abnormal_lacrimal_gland1.80067011
24MP0002254_reproductive_system_inflammat1.79390854
25MP0005379_endocrine/exocrine_gland_phen1.78687909
26MP0002420_abnormal_adaptive_immunity1.77013130
27MP0001819_abnormal_immune_cell1.76173623
28MP0009785_altered_susceptibility_to1.72893878
29MP0001533_abnormal_skeleton_physiology1.71409447
30MP0008877_abnormal_DNA_methylation1.70861882
31MP0002723_abnormal_immune_serum1.69321281
32MP0002877_abnormal_melanocyte_morpholog1.68674768
33MP0003828_pulmonary_edema1.64317477
34MP0002277_abnormal_respiratory_mucosa1.63605492
35MP0002138_abnormal_hepatobiliary_system1.62614559
36MP0005464_abnormal_platelet_physiology1.59435931
37MP0006292_abnormal_olfactory_placode1.54220438
38MP0000569_abnormal_digit_pigmentation1.54008697
39MP0004381_abnormal_hair_follicle1.50477624
40MP0002398_abnormal_bone_marrow1.46944004
41MP0005075_abnormal_melanosome_morpholog1.46635215
42MP0010234_abnormal_vibrissa_follicle1.46295428
43MP0002419_abnormal_innate_immunity1.45794990
44MP0004883_abnormal_blood_vessel1.45678381
45MP0005646_abnormal_pituitary_gland1.44219102
46MP0002405_respiratory_system_inflammati1.41764905
47MP0003436_decreased_susceptibility_to1.39968919
48MP0001853_heart_inflammation1.36134069
49MP0000716_abnormal_immune_system1.35066210
50MP0004808_abnormal_hematopoietic_stem1.28498470
51MP0008260_abnormal_autophagy1.27891049
52MP0005076_abnormal_cell_differentiation1.27812180
53MP0002102_abnormal_ear_morphology1.24567254
54MP0003656_abnormal_erythrocyte_physiolo1.24122541
55MP0008007_abnormal_cellular_replicative1.20002637
56MP0002396_abnormal_hematopoietic_system1.19774862
57MP0001873_stomach_inflammation1.17731922
58MP0005025_abnormal_response_to1.15208464
59MP0003303_peritoneal_inflammation1.15049842
60MP0000627_abnormal_mammary_gland1.13138138
61MP0003183_abnormal_peptide_metabolism1.12532620
62MP0005164_abnormal_response_to1.11667954
63MP0000703_abnormal_thymus_morphology1.11411955
64MP0003191_abnormal_cellular_cholesterol1.10160644
65MP0001984_abnormal_olfaction1.09930198
66MP0003693_abnormal_embryo_hatching1.04085592
67MP0008469_abnormal_protein_level1.04037552
68MP0003091_abnormal_cell_migration1.02809273
69MP0001119_abnormal_female_reproductive1.01618521
70MP0001188_hyperpigmentation1.01227120
71MP0001348_abnormal_lacrimal_gland1.00087332
72MP0010155_abnormal_intestine_physiology0.98138015
73MP0005451_abnormal_body_composition0.97715195
74MP0005397_hematopoietic_system_phenotyp0.97165269
75MP0001545_abnormal_hematopoietic_system0.97165269
76MP0009333_abnormal_splenocyte_physiolog0.97029693
77MP0001881_abnormal_mammary_gland0.97016607
78MP0002876_abnormal_thyroid_physiology0.96053688
79MP0003724_increased_susceptibility_to0.95326432
80MP0003221_abnormal_cardiomyocyte_apopto0.95132913
81MP0002722_abnormal_immune_system0.94205589
82MP0000689_abnormal_spleen_morphology0.94028664
83MP0002429_abnormal_blood_cell0.93118812
84MP0001502_abnormal_circadian_rhythm0.92365309
85MP0004782_abnormal_surfactant_physiolog0.91711315
86MP0002638_abnormal_pupillary_reflex0.91306654
87MP0001501_abnormal_sleep_pattern0.90829586
88MP0000490_abnormal_crypts_of0.90662960
89MP0009278_abnormal_bone_marrow0.90285080
90MP0003941_abnormal_skin_development0.90028366
91MP0008004_abnormal_stomach_pH0.90005050
92MP0003448_altered_tumor_morphology0.86638778
93MP0003045_fibrosis0.85892531
94MP0006054_spinal_hemorrhage0.84555686
95MP0010094_abnormal_chromosome_stability0.84501376
96MP0004947_skin_inflammation0.81841642
97MP0001845_abnormal_inflammatory_respons0.81545209
98MP0009763_increased_sensitivity_to0.78988809
99MP0003300_gastrointestinal_ulcer0.77304588
100MP0005171_absent_coat_pigmentation0.76572908
101MP0003136_yellow_coat_color0.75272282
102MP0010307_abnormal_tumor_latency0.74811739
103MP0002933_joint_inflammation0.74807016
104MP0005390_skeleton_phenotype0.74504677
105MP0002019_abnormal_tumor_incidence0.74435072
106MP0000858_altered_metastatic_potential0.72581511
107MP0003690_abnormal_glial_cell0.71990819
108MP0005174_abnormal_tail_pigmentation0.71879824
109MP0002998_abnormal_bone_remodeling0.70088604
110MP0004484_altered_response_of0.69999774
111MP0009765_abnormal_xenobiotic_induced0.69938464
112MP0003121_genomic_imprinting0.68958051
113MP0003718_maternal_effect0.68709218
114MP0000015_abnormal_ear_pigmentation0.68657446
115MP0003077_abnormal_cell_cycle0.67831066
116MP0001919_abnormal_reproductive_system0.67335902
117MP0003795_abnormal_bone_structure0.66977515
118MP0000249_abnormal_blood_vessel0.66502710
119MP0003172_abnormal_lysosome_physiology0.66444203
120MP0003453_abnormal_keratinocyte_physiol0.65987948
121MP0003936_abnormal_reproductive_system0.65501638
122MP0002332_abnormal_exercise_endurance0.64874932
123MP0001663_abnormal_digestive_system0.64467527
124MP0009764_decreased_sensitivity_to0.63742928
125MP0002132_abnormal_respiratory_system0.63095387
126MP0005621_abnormal_cell_physiology0.62267946
127MP0001851_eye_inflammation0.62056175
128MP0002095_abnormal_skin_pigmentation0.60364356
129MP0003937_abnormal_limbs/digits/tail_de0.59332453
130MP0009250_abnormal_appendicular_skeleto0.58509046
131MP0003786_premature_aging0.58192973
132MP0003866_abnormal_defecation0.58036942
133MP0005388_respiratory_system_phenotype0.56368869
134MP0002133_abnormal_respiratory_system0.56368869
135MP0008995_early_reproductive_senescence0.55934236
136MP0003252_abnormal_bile_duct0.55387375
137MP0005166_decreased_susceptibility_to0.52819784
138MP0001542_abnormal_bone_strength0.52722529
139MP0004130_abnormal_muscle_cell0.51715520

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.54320192
2Fibular aplasia (HP:0002990)4.45002637
3Retrobulbar optic neuritis (HP:0100654)3.92309025
4Optic neuritis (HP:0100653)3.92309025
5Pustule (HP:0200039)3.69108553
6Combined immunodeficiency (HP:0005387)3.49860724
7Spontaneous hematomas (HP:0007420)3.46110033
8Abnormality of the fingertips (HP:0001211)3.38175478
9Aplasia involving bones of the upper limbs (HP:0009823)3.37284138
10Aplasia of the phalanges of the hand (HP:0009802)3.37284138
11Aplasia involving bones of the extremities (HP:0009825)3.37284138
12Recurrent skin infections (HP:0001581)3.29162691
13Abnormality of macrophages (HP:0004311)3.08902118
14Orchitis (HP:0100796)3.07418319
15Myositis (HP:0100614)3.06162904
16Lip pit (HP:0100267)3.01598206
17Autoimmune thrombocytopenia (HP:0001973)2.95927806
18Hemoptysis (HP:0002105)2.93721964
19Abnormality of T cell physiology (HP:0011840)2.80225304
20Acute myeloid leukemia (HP:0004808)2.78573321
21Chromsome breakage (HP:0040012)2.77740656
22Chest pain (HP:0100749)2.70399645
23Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.69384729
24Asymmetry of the thorax (HP:0001555)2.65371568
25Abnormal respiratory motile cilium physiology (HP:0012261)2.61113520
26Papilledema (HP:0001085)2.59276760
27Mediastinal lymphadenopathy (HP:0100721)2.59092794
28Increased IgM level (HP:0003496)2.58404810
29Increased IgE level (HP:0003212)2.56306758
30Pulmonary embolism (HP:0002204)2.55651997
31Inflammation of the large intestine (HP:0002037)2.55022905
32Pulmonary infiltrates (HP:0002113)2.54515105
33Gingivitis (HP:0000230)2.53067628
34Pancreatic fibrosis (HP:0100732)2.52480606
35Abnormality of the phalanges of the hallux (HP:0010057)2.52246283
36Papillary thyroid carcinoma (HP:0002895)2.50579923
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.50178552
38Abnormal ciliary motility (HP:0012262)2.46950696
39Eczematoid dermatitis (HP:0000976)2.46755595
40Recurrent gram-negative bacterial infections (HP:0005420)2.45861995
41Eosinophilia (HP:0001880)2.43865932
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.43238509
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.41670377
44Arterial thrombosis (HP:0004420)2.39095329
45Neoplasm of the tracheobronchial system (HP:0100552)2.38632094
46Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.37970349
47Gastrointestinal inflammation (HP:0004386)2.35799747
48Aplasia/Hypoplasia of the fibula (HP:0006492)2.34400421
49Gangrene (HP:0100758)2.34098309
50Prostate neoplasm (HP:0100787)2.33519458
51Rhinitis (HP:0012384)2.33080200
52Recurrent abscess formation (HP:0002722)2.31449422
53Hypoplasia of the thymus (HP:0000778)2.31192168
54Lymphopenia (HP:0001888)2.28717239
55Abnormality of cells of the lymphoid lineage (HP:0012140)2.28038748
56Recurrent fungal infections (HP:0002841)2.26536770
57Thyroiditis (HP:0100646)2.26288899
58Abnormality of T cell number (HP:0011839)2.26133224
59Slow saccadic eye movements (HP:0000514)2.23859513
60Urticaria (HP:0001025)2.23841992
61Alveolar cell carcinoma (HP:0006519)2.21046613
62Recurrent bacterial skin infections (HP:0005406)2.19207512
63Basal cell carcinoma (HP:0002671)2.18508041
64Abnormality of the pleura (HP:0002103)2.18093911
65Prolonged bleeding time (HP:0003010)2.17931008
66Anorexia (HP:0002039)2.17844749
67Premature loss of primary teeth (HP:0006323)2.15955823
68Gingival bleeding (HP:0000225)2.15597216
69True hermaphroditism (HP:0010459)2.15013312
70Hematochezia (HP:0002573)2.14685825
71Subacute progressive viral hepatitis (HP:0006572)2.14518881
72Peritonitis (HP:0002586)2.14023288
73B lymphocytopenia (HP:0010976)2.13382759
74Abnormality of B cell number (HP:0010975)2.13382759
75Bronchiectasis (HP:0002110)2.13101302
76Vasculitis (HP:0002633)2.12695469
77Keratoconjunctivitis sicca (HP:0001097)2.12120694
78Autoimmune hemolytic anemia (HP:0001890)2.11676992
79Natal tooth (HP:0000695)2.11406210
80Abnormality of eosinophils (HP:0001879)2.11332868
81Epistaxis (HP:0000421)2.09607515
82Keratitis (HP:0000491)2.08611810
83Sepsis (HP:0100806)2.07031053
84Papilloma (HP:0012740)2.06774408
85Verrucae (HP:0200043)2.06774408
86Periodontitis (HP:0000704)2.06708219
87Obstructive lung disease (HP:0006536)2.05241961
88Chronic obstructive pulmonary disease (HP:0006510)2.05241961
89Pancreatic cysts (HP:0001737)2.03772841
90Colitis (HP:0002583)2.03534568
91Viral hepatitis (HP:0006562)2.01939933
92Glomerulopathy (HP:0100820)2.01579922
93Capillary hemangiomas (HP:0005306)2.00198173
94Lymphoma (HP:0002665)1.99779274
95Gastrointestinal infarctions (HP:0005244)1.98907232
96IgG deficiency (HP:0004315)1.97028871
97Osteomyelitis (HP:0002754)1.96153204
98Joint swelling (HP:0001386)1.95384102
99Thoracic kyphosis (HP:0002942)1.95184635
100Recurrent viral infections (HP:0004429)1.93572106
101Panhypogammaglobulinemia (HP:0003139)1.93474854
102Granulocytopenia (HP:0001913)1.93292842
103Cellulitis (HP:0100658)1.92271314
104Flat capital femoral epiphysis (HP:0003370)1.91282790
105Keratoconjunctivitis (HP:0001096)1.90002831
106Abnormality of incisor morphology (HP:0011063)1.89159909
107Hypergammaglobulinemia (HP:0010702)1.88870509
108Amyotrophic lateral sclerosis (HP:0007354)1.88398145
109Leukocytosis (HP:0001974)1.87869496
110Tetraparesis (HP:0002273)1.86350297
111T lymphocytopenia (HP:0005403)1.86232228
112Thyroid-stimulating hormone excess (HP:0002925)1.85396127
113Chronic sinusitis (HP:0011109)1.84715959
114Abnormality of T cells (HP:0002843)1.84601427
115Abnormality of the peritoneum (HP:0002585)1.84235230
116Encephalitis (HP:0002383)1.83478141
117Aplasia/Hypoplasia of the tibia (HP:0005772)1.82309299
118Stomatitis (HP:0010280)1.81649902
119Persistence of primary teeth (HP:0006335)1.80976149
120Abnormal hair whorl (HP:0010721)1.79310163
121Chronic otitis media (HP:0000389)1.79172447
122Spondylolisthesis (HP:0003302)1.79016970
123Episodic fever (HP:0001954)1.78481854
124Meningitis (HP:0001287)1.78163964
125Abnormality of the columella (HP:0009929)1.77985854
126Ectopic kidney (HP:0000086)1.75688206
127Short tibia (HP:0005736)1.74468677
128Abnormality of the nasal septum (HP:0000419)1.72746656
129Severe combined immunodeficiency (HP:0004430)1.72072692
130Abnormality of the distal phalanx of the thumb (HP:0009617)1.70175053
131Chronic diarrhea (HP:0002028)1.69110354
132Agammaglobulinemia (HP:0004432)1.68663303
133Fibular hypoplasia (HP:0003038)1.66082111
134Recurrent cutaneous fungal infections (HP:0011370)1.65734052
135Chronic mucocutaneous candidiasis (HP:0002728)1.65734052
136Absent frontal sinuses (HP:0002688)1.65302691
137Thrombocytosis (HP:0001894)1.65078299
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.65016477
139Abnormality of the proximal phalanges of the hand (HP:0009834)1.64832606
140Abnormality of the prostate (HP:0008775)1.63390571
141Stomach cancer (HP:0012126)1.61444113
142Preaxial hand polydactyly (HP:0001177)1.60423596
143Anhidrosis (HP:0000970)1.59116989
144Recurrent bronchitis (HP:0002837)1.58530231
145Microglossia (HP:0000171)1.56930247
146Abnormality of the thoracic spine (HP:0100711)1.55280872
147Febrile seizures (HP:0002373)1.53725427
148Metaphyseal dysplasia (HP:0100255)1.53468273
149IgM deficiency (HP:0002850)1.53403920
150IgA deficiency (HP:0002720)1.52636463

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.14660279
2LATS13.00200188
3JAK32.71778394
4TXK2.70767965
5MAP3K132.67611802
6FES2.63537094
7GRK62.46497271
8CSK2.32118746
9ZAP702.11884763
10RIPK42.10411530
11NUAK12.01732163
12BLK1.96346323
13BTK1.90561949
14SGK21.88659684
15BMPR21.86896852
16FRK1.86527367
17MAP3K101.83418795
18PRPF4B1.83356757
19TAOK31.82417339
20CAMK1D1.81714721
21CHUK1.80370452
22IKBKB1.79645492
23PLK41.70892031
24EPHA31.67472047
25CCNB11.66407148
26MUSK1.62962537
27STK38L1.59499822
28STK31.59486731
29IRAK31.54062495
30IRAK41.53143029
31IKBKE1.50692839
32CDC71.45349310
33MAP2K31.44958981
34JAK11.44604617
35SIK31.43574057
36CDK31.40332675
37MAP3K61.39847188
38TEC1.36292403
39FGFR31.34750983
40SRPK11.32140477
41MAPK131.30112652
42MST41.30061561
43STK241.28082905
44TGFBR21.27847186
45RAF11.27775578
46NLK1.27069282
47FGR1.23758820
48TYK21.23355978
49ACVR1B1.19031861
50PIK3CG1.17917550
51CSF1R1.17570600
52ERBB41.16677682
53NTRK21.15693583
54NEK91.14223653
55MARK31.12867677
56SGK31.12438389
57BMPR1B1.02545271
58SIK21.02229435
59MAPK71.02035040
60MAP4K10.99953776
61CDK90.99415714
62KSR10.98000738
63PIM10.96021988
64PRKAA20.94149450
65TRPM70.92957799
66GRK70.91366025
67TNK20.91098825
68IRAK10.88966107
69CAMK1G0.88666482
70DYRK1A0.88440954
71TBK10.87211501
72KSR20.86979384
73LATS20.85569566
74CDK120.83057307
75DMPK0.82452446
76CHEK20.76887406
77CAMKK10.76678164
78LCK0.76445967
79CDK60.75766040
80MELK0.75674543
81MKNK20.75438380
82AKT30.73822964
83TAOK20.73091810
84MAP3K50.72979443
85STK100.72246873
86MATK0.69773476
87CDK40.68091306
88CAMKK20.67320410
89KIT0.65946611
90EPHB10.65658381
91MAP3K20.65437815
92SGK2230.64584544
93SGK4940.64584544
94PASK0.63396772
95SGK10.63152953
96PTK2B0.62965909
97RPS6KA40.62946943
98CASK0.61678563
99PRKCQ0.60916214
100BCR0.60037552
101EIF2AK20.59711190
102MAP3K10.59451294
103MOS0.59031336
104MARK20.58904530
105ERBB30.58630325
106LMTK20.57738552
107ABL10.57418311
108HCK0.57412294
109BRAF0.57016487
110PLK20.56633974
111FYN0.55997822
112NEK60.55753711
113MAP3K30.54648878
114SYK0.54168992
115YES10.52320308
116MAP3K70.51723362
117PDGFRB0.50604396
118BRD40.50046530
119PDK10.49265250
120ZAK0.49163041
121JAK20.47883101
122MAPK120.47581844
123LYN0.46797544
124HIPK20.46780481
125STK380.46658851
126MAP2K70.46032940
127EGFR0.45595634
128ATM0.45156647
129STK40.44840929
130STK110.43839483
131AKT10.43780623
132CHEK10.43718850
133TAOK10.43394434
134ITK0.43369618
135CDK80.41729359
136RET0.41489452
137IRAK20.41371651
138CAMK40.39104925
139IGF1R0.38677740
140TNIK0.38636522
141ERN10.38434383
142GRK50.37762101
143MAP3K120.37481946
144RPS6KB10.37460513
145CDC42BPA0.37034619
146FGFR40.36695298

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053302.35410745
2Graft-versus-host disease_Homo sapiens_hsa053322.34288430
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.17139774
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84169011
5Primary immunodeficiency_Homo sapiens_hsa053401.84102760
6Intestinal immune network for IgA production_Homo sapiens_hsa046721.80759361
7NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69887382
8Circadian rhythm_Homo sapiens_hsa047101.69783915
9Autoimmune thyroid disease_Homo sapiens_hsa053201.67473679
10Leishmaniasis_Homo sapiens_hsa051401.67392547
11Measles_Homo sapiens_hsa051621.64750652
12Type I diabetes mellitus_Homo sapiens_hsa049401.62615538
13TNF signaling pathway_Homo sapiens_hsa046681.56304785
14Osteoclast differentiation_Homo sapiens_hsa043801.49300042
15T cell receptor signaling pathway_Homo sapiens_hsa046601.43961638
16Non-small cell lung cancer_Homo sapiens_hsa052231.42813093
17Staphylococcus aureus infection_Homo sapiens_hsa051501.42530935
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.38031527
19Herpes simplex infection_Homo sapiens_hsa051681.31367235
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27881420
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26441098
22B cell receptor signaling pathway_Homo sapiens_hsa046621.26334270
23Chemokine signaling pathway_Homo sapiens_hsa040621.23451766
24Toxoplasmosis_Homo sapiens_hsa051451.23279214
25Prolactin signaling pathway_Homo sapiens_hsa049171.22825182
26Pancreatic cancer_Homo sapiens_hsa052121.20280052
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19994496
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17967284
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16168482
30RNA degradation_Homo sapiens_hsa030181.15581969
31Hematopoietic cell lineage_Homo sapiens_hsa046401.15464585
32Influenza A_Homo sapiens_hsa051641.13937230
33p53 signaling pathway_Homo sapiens_hsa041151.12541603
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06511207
35Fanconi anemia pathway_Homo sapiens_hsa034601.06214744
36Cell cycle_Homo sapiens_hsa041101.05472017
37Hepatitis B_Homo sapiens_hsa051611.02780917
38Apoptosis_Homo sapiens_hsa042100.98440636
39Shigellosis_Homo sapiens_hsa051310.97307680
40Homologous recombination_Homo sapiens_hsa034400.97104158
41Rheumatoid arthritis_Homo sapiens_hsa053230.92884659
42Acute myeloid leukemia_Homo sapiens_hsa052210.90983629
43MicroRNAs in cancer_Homo sapiens_hsa052060.90874667
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89319644
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88792589
46African trypanosomiasis_Homo sapiens_hsa051430.87785655
47Malaria_Homo sapiens_hsa051440.87326148
48Tuberculosis_Homo sapiens_hsa051520.86753190
49Dorso-ventral axis formation_Homo sapiens_hsa043200.86601358
50Viral myocarditis_Homo sapiens_hsa054160.86254204
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85592026
52Small cell lung cancer_Homo sapiens_hsa052220.84840343
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84454534
54Basal transcription factors_Homo sapiens_hsa030220.84363562
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83793168
56TGF-beta signaling pathway_Homo sapiens_hsa043500.80756988
57FoxO signaling pathway_Homo sapiens_hsa040680.79030485
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79023724
59Inositol phosphate metabolism_Homo sapiens_hsa005620.77679245
60HTLV-I infection_Homo sapiens_hsa051660.76862416
61Pertussis_Homo sapiens_hsa051330.76692424
62Nicotine addiction_Homo sapiens_hsa050330.76222141
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75572897
64Chronic myeloid leukemia_Homo sapiens_hsa052200.75435428
65Asthma_Homo sapiens_hsa053100.75415912
66Adherens junction_Homo sapiens_hsa045200.75386266
67Antigen processing and presentation_Homo sapiens_hsa046120.75017319
68* Viral carcinogenesis_Homo sapiens_hsa052030.73397224
69Prostate cancer_Homo sapiens_hsa052150.72218224
70Sphingolipid metabolism_Homo sapiens_hsa006000.71738867
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70357819
72Epstein-Barr virus infection_Homo sapiens_hsa051690.69731108
73* MAPK signaling pathway_Homo sapiens_hsa040100.69506186
74Colorectal cancer_Homo sapiens_hsa052100.68376037
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68370027
76ErbB signaling pathway_Homo sapiens_hsa040120.66436277
77Choline metabolism in cancer_Homo sapiens_hsa052310.65060631
78mTOR signaling pathway_Homo sapiens_hsa041500.64733260
79Salmonella infection_Homo sapiens_hsa051320.62772255
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62666684
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62536958
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61467189
83Platelet activation_Homo sapiens_hsa046110.60975845
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.60038338
85GnRH signaling pathway_Homo sapiens_hsa049120.59159914
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.58806622
87Endometrial cancer_Homo sapiens_hsa052130.58592081
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.58308905
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.57588251
90Phagosome_Homo sapiens_hsa041450.57521267
91Fatty acid biosynthesis_Homo sapiens_hsa000610.57395212
92Non-homologous end-joining_Homo sapiens_hsa034500.57243253
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55701263
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55425917
95Endocytosis_Homo sapiens_hsa041440.54913906
96Hepatitis C_Homo sapiens_hsa051600.54301460
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54167192
98Legionellosis_Homo sapiens_hsa051340.53700868
99Ovarian steroidogenesis_Homo sapiens_hsa049130.53602359
100* Ras signaling pathway_Homo sapiens_hsa040140.52896158
101Glutamatergic synapse_Homo sapiens_hsa047240.50937032
102cAMP signaling pathway_Homo sapiens_hsa040240.50868582
103Long-term depression_Homo sapiens_hsa047300.50611107
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50391191
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50300118
106Renal cell carcinoma_Homo sapiens_hsa052110.50281687
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50162811
108Long-term potentiation_Homo sapiens_hsa047200.49124263
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49110234
110VEGF signaling pathway_Homo sapiens_hsa043700.48636972
111Serotonergic synapse_Homo sapiens_hsa047260.48526488
112Thyroid cancer_Homo sapiens_hsa052160.47928191
113Glioma_Homo sapiens_hsa052140.46125693
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46082709
115Rap1 signaling pathway_Homo sapiens_hsa040150.44494575
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42950976
117HIF-1 signaling pathway_Homo sapiens_hsa040660.42926741
118Amoebiasis_Homo sapiens_hsa051460.42202146
119Regulation of autophagy_Homo sapiens_hsa041400.41959394
120Type II diabetes mellitus_Homo sapiens_hsa049300.40185880
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38061388
122Pathways in cancer_Homo sapiens_hsa052000.37595495
123Insulin resistance_Homo sapiens_hsa049310.37300099
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37091591
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.34998285

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