RASA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.71116304
2positive regulation by organism of defense response of other organism involved in symbiotic interact5.71116304
3modulation by symbiont of host immune response (GO:0052553)5.71116304
4positive regulation by symbiont of host defense response (GO:0052509)5.71116304
5modulation by symbiont of host defense response (GO:0052031)5.71116304
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.71116304
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.42405742
8positive regulation of interferon-alpha production (GO:0032727)4.95928124
9neutrophil activation involved in immune response (GO:0002283)4.77598518
10immunoglobulin mediated immune response (GO:0016064)4.68654053
11regulation of interferon-alpha production (GO:0032647)4.65660295
12positive regulation of gamma-delta T cell activation (GO:0046645)4.52002884
13response to peptidoglycan (GO:0032494)4.51719939
14regulation of interferon-beta biosynthetic process (GO:0045357)4.50869250
15NIK/NF-kappaB signaling (GO:0038061)4.47574777
16macrophage activation involved in immune response (GO:0002281)4.46326436
17response to muramyl dipeptide (GO:0032495)4.45904644
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.41507376
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.41507376
20cellular response to type I interferon (GO:0071357)4.28115122
21type I interferon signaling pathway (GO:0060337)4.28115122
22positive regulation of antigen processing and presentation (GO:0002579)4.26952074
23response to type I interferon (GO:0034340)4.24035399
24antigen processing and presentation of endogenous antigen (GO:0019883)4.22256854
25sarcoplasmic reticulum calcium ion transport (GO:0070296)4.07681328
26response to host immune response (GO:0052572)3.98480024
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.98480024
28response to interferon-alpha (GO:0035455)3.91221187
29regulation of skeletal muscle contraction (GO:0014819)3.84656474
30regulation of dendritic cell antigen processing and presentation (GO:0002604)3.81335345
31positive regulation of interferon-beta production (GO:0032728)3.75854820
32regulation of RIG-I signaling pathway (GO:0039535)3.74473512
33regulation of antigen processing and presentation (GO:0002577)3.73255704
34interferon-gamma-mediated signaling pathway (GO:0060333)3.70684365
35natural killer cell mediated immunity (GO:0002228)3.67737543
36natural killer cell mediated cytotoxicity (GO:0042267)3.67737543
37positive regulation of B cell differentiation (GO:0045579)3.67354703
38response to host (GO:0075136)3.67191651
39response to host defenses (GO:0052200)3.67191651
40response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.67191651
41cellular response to interferon-beta (GO:0035458)3.66109555
42regulation of interleukin-12 biosynthetic process (GO:0045075)3.62733607
43regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.61944206
44granulocyte activation (GO:0036230)3.59226775
45neutrophil activation (GO:0042119)3.58738496
46microglial cell activation (GO:0001774)3.51511489
47defense response to protozoan (GO:0042832)3.51447872
48respiratory burst (GO:0045730)3.50520532
49myeloid cell activation involved in immune response (GO:0002275)3.47894091
50negative regulation of viral genome replication (GO:0045071)3.46097223
51B cell mediated immunity (GO:0019724)3.45466378
52regulation of B cell receptor signaling pathway (GO:0050855)3.36009461
53response to interferon-beta (GO:0035456)3.34608782
54skeletal muscle contraction (GO:0003009)3.33234917
55myeloid dendritic cell activation (GO:0001773)3.31643521
56muscle filament sliding (GO:0030049)3.31159740
57actin-myosin filament sliding (GO:0033275)3.31159740
58lipopolysaccharide-mediated signaling pathway (GO:0031663)3.29647306
59myeloid dendritic cell differentiation (GO:0043011)3.27198246
60negative regulation of cell killing (GO:0031342)3.26456703
61negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.26456703
62cellular response to virus (GO:0098586)3.21794564
63positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.20551276
64regulation of T-helper 1 cell differentiation (GO:0045625)3.17051892
65positive regulation of interleukin-12 production (GO:0032735)3.16443997
66regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.13567029
67regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.12458601
68cellular response to exogenous dsRNA (GO:0071360)3.12116754
69positive regulation of natural killer cell differentiation (GO:0032825)3.11341561
70negative regulation of granulocyte differentiation (GO:0030853)3.10710591
71response to protozoan (GO:0001562)3.06807447
72macrophage activation (GO:0042116)3.05950837
73regulation of B cell differentiation (GO:0045577)3.04755261
74detection of molecule of bacterial origin (GO:0032490)3.04654929
75dendritic cell differentiation (GO:0097028)3.03636986
76positive regulation of cellular amide metabolic process (GO:0034250)3.03269452
77positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.98374231
78germinal center formation (GO:0002467)2.98259672
79membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.98259659
80antigen processing and presentation via MHC class Ib (GO:0002475)2.95890701
81negative regulation of erythrocyte differentiation (GO:0045647)2.95359048
82I-kappaB phosphorylation (GO:0007252)2.93933847
83negative regulation of interleukin-12 production (GO:0032695)2.93187850
84positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.92098329
85positive regulation of interleukin-1 beta secretion (GO:0050718)2.91748887
86neuronal action potential propagation (GO:0019227)2.90182591
87creatine metabolic process (GO:0006600)2.88768160
88negative regulation of interleukin-17 production (GO:0032700)2.88704789
89regulation of gamma-delta T cell activation (GO:0046643)2.86648471
90myeloid leukocyte activation (GO:0002274)2.84916772
91mature B cell differentiation (GO:0002335)2.83025110
92positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.83007886
93regulation of interferon-beta production (GO:0032648)2.82381811
94T cell migration (GO:0072678)2.81884533
95positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.81824977
96regulation of necroptotic process (GO:0060544)2.80869243
97regulation of mast cell degranulation (GO:0043304)2.80346966
98regulation of interleukin-12 production (GO:0032655)2.79339624
99neutrophil mediated immunity (GO:0002446)2.78738615
100leukocyte mediated cytotoxicity (GO:0001909)2.77308204
101regulation of interleukin-8 biosynthetic process (GO:0045414)2.76983264
102regulation of interleukin-1 beta secretion (GO:0050706)2.76364404
103regulation of type I interferon-mediated signaling pathway (GO:0060338)2.74663415
104cellular response to interferon-gamma (GO:0071346)2.74632430
105positive regulation of response to biotic stimulus (GO:0002833)2.74222566
106positive regulation of heat generation (GO:0031652)2.74109202
107defense response to virus (GO:0051607)2.74016913
108activated T cell proliferation (GO:0050798)2.73706043
109superoxide anion generation (GO:0042554)2.70800649
110lymphocyte mediated immunity (GO:0002449)2.69325741
111positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.68044322
112cellular response to zinc ion (GO:0071294)2.66543719
113positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.64195517
114postsynaptic membrane organization (GO:0001941)2.60850485
115membrane depolarization during action potential (GO:0086010)2.59693648
116response to inactivity (GO:0014854)2.59656271
117skeletal muscle adaptation (GO:0043501)2.56695443
118positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.54627559
119actin-mediated cell contraction (GO:0070252)2.54565410
120regulation of relaxation of muscle (GO:1901077)2.51796780
121neuromuscular synaptic transmission (GO:0007274)2.49873560
122regulation of gamma-delta T cell differentiation (GO:0045586)2.47894742
123striated muscle contraction (GO:0006941)2.42248072
124negative regulation of protein oligomerization (GO:0032460)2.40175355
125behavioral response to nicotine (GO:0035095)2.40144086
126regulation of synapse structural plasticity (GO:0051823)2.39987917
127regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.39081589
128dendritic spine morphogenesis (GO:0060997)2.37184967
129myofibril assembly (GO:0030239)2.36511942
130positive regulation of Rap GTPase activity (GO:0032854)2.32615595
131skeletal muscle fiber development (GO:0048741)2.20709644
132pyrimidine nucleobase catabolic process (GO:0006208)2.20383419
133synaptic transmission, cholinergic (GO:0007271)2.19730340
134positive regulation of CREB transcription factor activity (GO:0032793)2.18854374
135regulation of synapse maturation (GO:0090128)2.14359986
136positive thymic T cell selection (GO:0045059)2.13514126
137regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.12327617
138mannose metabolic process (GO:0006013)2.12273311
139positive regulation of synapse maturation (GO:0090129)2.10199594
140positive regulation of mast cell activation (GO:0033005)2.09946678
141actin filament-based movement (GO:0030048)2.09101483
142ionotropic glutamate receptor signaling pathway (GO:0035235)2.07263034
143synaptic vesicle maturation (GO:0016188)2.04026696
144macroautophagy (GO:0016236)2.03524407
145striated muscle atrophy (GO:0014891)2.03232537
146positive regulation of calcium-mediated signaling (GO:0050850)2.03060723
147negative regulation of cytosolic calcium ion concentration (GO:0051481)2.02776406
148negative regulation of T cell mediated immunity (GO:0002710)2.02709329
149regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.02189286
150regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.00694618
151response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.00648264
152regulation of Rap GTPase activity (GO:0032317)1.99956149
153regulation of respiratory gaseous exchange by neurological system process (GO:0002087)1.99310615
154positive T cell selection (GO:0043368)1.97744495
155interferon-gamma production (GO:0032609)1.96657072
156positive regulation of mast cell activation involved in immune response (GO:0033008)1.95975809
157positive regulation of mast cell degranulation (GO:0043306)1.95975809
158negative thymic T cell selection (GO:0045060)1.95170145
159myotube cell development (GO:0014904)1.94809082
160negative regulation of lymphocyte mediated immunity (GO:0002707)1.93627273
161regulation of ARF protein signal transduction (GO:0032012)1.93505216
162negative regulation of amyloid precursor protein catabolic process (GO:1902992)1.93420980
163positive regulation of interleukin-2 biosynthetic process (GO:0045086)1.92832707
164auditory behavior (GO:0031223)1.90704085
165nitric oxide mediated signal transduction (GO:0007263)1.89987531
166synaptic transmission, glutamatergic (GO:0035249)1.87011584
167cerebellar Purkinje cell differentiation (GO:0021702)1.86815405
168nucleobase catabolic process (GO:0046113)1.86136356
169muscle contraction (GO:0006936)1.84812994
170regulation of short-term neuronal synaptic plasticity (GO:0048172)1.84631307
171negative T cell selection (GO:0043383)1.84211812
172striated muscle adaptation (GO:0014888)1.84108072
173neurotransmitter-gated ion channel clustering (GO:0072578)1.83623941
174regulation of mast cell activation (GO:0033003)1.82245120
175synaptic vesicle exocytosis (GO:0016079)1.82056856
176positive regulation of excitatory postsynaptic membrane potential (GO:2000463)1.81871380
177calcium ion import (GO:0070509)1.81158087
178vocalization behavior (GO:0071625)1.81144380

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.82244484
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.50873490
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.44016328
4EZH2_22144423_ChIP-Seq_EOC_Human5.13672481
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.60402417
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.39497209
7IRF8_27001747_Chip-Seq_BMDM_Mouse4.08812214
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.86591280
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.59235786
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.53849624
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.43710821
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.11545223
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.99462478
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.90782947
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.88218048
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.74906289
17DROSHA_22980978_ChIP-Seq_HELA_Human2.70330971
18SCL_19346495_ChIP-Seq_HPC-7_Human2.64980490
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.50864471
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50857403
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.49694567
22SPI1_23547873_ChIP-Seq_NB4_Human2.40741356
23E2F7_22180533_ChIP-Seq_HELA_Human2.35849323
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.11682527
25* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.09861165
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08752391
27VDR_21846776_ChIP-Seq_THP-1_Human2.03258109
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00981657
29VDR_24763502_ChIP-Seq_THP-1_Human2.00878331
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96931213
31SPI1_23127762_ChIP-Seq_K562_Human1.96024162
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93040654
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89914556
34PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.87493925
35MYB_26560356_Chip-Seq_TH2_Human1.85561929
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84268881
37* MAF_26560356_Chip-Seq_TH1_Human1.79360104
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76042027
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76037783
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74587239
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.73078846
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.72598352
43REST_21632747_ChIP-Seq_MESCs_Mouse1.70468189
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70132624
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.67698226
46* PU_27001747_Chip-Seq_BMDM_Mouse1.67559438
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66586469
48MYB_26560356_Chip-Seq_TH1_Human1.64752376
49GATA1_22025678_ChIP-Seq_K562_Human1.64421789
50RUNX_20019798_ChIP-Seq_JUKART_Human1.62943012
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62881926
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61504239
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.60663462
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59660612
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.55520347
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48287517
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.46620792
58PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45584783
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.45209708
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.43999154
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41069996
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40632297
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39108219
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38641849
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38384939
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38357458
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37433964
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.37406210
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36706170
70UTX_26944678_Chip-Seq_JUKART_Human1.35602883
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35305713
72VDR_24787735_ChIP-Seq_THP-1_Human1.34933272
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34184581
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33559991
75MYC_22102868_ChIP-Seq_BL_Human1.31113263
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30313509
77* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29341027
78* TCF7_22412390_ChIP-Seq_EML_Mouse1.28639143
79LXR_22292898_ChIP-Seq_THP-1_Human1.28444732
80GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27932094
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26949688
82GBX2_23144817_ChIP-Seq_PC3_Human1.23846365
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23780391
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.22135611
85EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21469586
86RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21469586
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19311802
88RARB_27405468_Chip-Seq_BRAIN_Mouse1.17848383
89CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17158566
90CTCF_27219007_Chip-Seq_Bcells_Human1.15914674
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15516006
92CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15506398
93* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15291757
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15122117
95GATA3_27048872_Chip-Seq_THYMUS_Human1.14041592
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13996288
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12799657
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11639819
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.11115056
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.10170080
101GATA3_26560356_Chip-Seq_TH2_Human1.08849044
102EED_16625203_ChIP-ChIP_MESCs_Mouse1.08132925
103TFEB_21752829_ChIP-Seq_HELA_Human1.07379507
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06587380
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06308662
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06255609
107MAF_26560356_Chip-Seq_TH2_Human1.03234369
108CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02550214
109GATA1_19941827_ChIP-Seq_MEL_Mouse1.00682247
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00677653
111NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00522944
112RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99847576
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98349850
114KDM2B_26808549_Chip-Seq_K562_Human0.98145529
115OCT4_19829295_ChIP-Seq_ESCs_Human0.96883499
116ERG_21242973_ChIP-ChIP_JURKAT_Human0.96701561
117* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96289110
118KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96233672
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95916331
120RING1B_27294783_Chip-Seq_ESCs_Mouse0.95303728
121BCL6_27268052_Chip-Seq_Bcells_Human0.93395954
122TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92040714
123AR_21572438_ChIP-Seq_LNCaP_Human0.91416430
124CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89254051
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89178555
126KDM2B_26808549_Chip-Seq_JURKAT_Human0.88093036
127CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87710034
128EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86909085
129WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86160804
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85746404
131* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85428406
132P68_20966046_ChIP-Seq_HELA_Human0.84900609
133SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84735400
134* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84477735
135KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84182560
136CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83799841
137RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.81481000
138BCOR_27268052_Chip-Seq_Bcells_Human0.81300344
139PU.1_20513432_ChIP-Seq_Bcells_Mouse0.78345142
140TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78291920
141SMC4_20622854_ChIP-Seq_HELA_Human0.77769074
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77722037
143TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.77365955
144SA1_27219007_Chip-Seq_Bcells_Human0.77082581
145KLF4_19829295_ChIP-Seq_ESCs_Human0.76922391
146TP53_20018659_ChIP-ChIP_R1E_Mouse0.76250627
147HOXB4_20404135_ChIP-ChIP_EML_Mouse0.76040393
148CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.74883174
149KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.74583507
150SA1_27219007_Chip-Seq_ERYTHROID_Human0.74262831
151STAT1_20625510_ChIP-Seq_HELA_Human0.73637796
152GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.72932417
153OCT4_20526341_ChIP-Seq_ESCs_Human0.72846466
154KDM2B_26808549_Chip-Seq_DND41_Human0.72200495
155* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.71814163
156GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68255551
157RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.68143906
158ELF1_17652178_ChIP-ChIP_JURKAT_Human0.63669647
159FOXM1_23109430_ChIP-Seq_U2OS_Human0.63412404
160TP63_17297297_ChIP-ChIP_HaCaT_Human0.59149838
161CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.58868886
162SPI1_20517297_ChIP-Seq_HL60_Human0.58705657
163FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.57957903
164* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.57070196
165* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.57070196
166* CTCF_26484167_Chip-Seq_Bcells_Mouse0.57040927
167BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.56112658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.66192670
2MP0004145_abnormal_muscle_electrophysio3.42076702
3MP0009785_altered_susceptibility_to3.40351900
4MP0003436_decreased_susceptibility_to3.17746637
5MP0000685_abnormal_immune_system3.09473282
6MP0002148_abnormal_hypersensitivity_rea3.01268080
7MP0004510_myositis2.98017615
8* MP0002419_abnormal_innate_immunity2.92040236
9MP0005000_abnormal_immune_tolerance2.80769054
10MP0001790_abnormal_immune_system2.78564091
11MP0005387_immune_system_phenotype2.78564091
12MP0000569_abnormal_digit_pigmentation2.78431756
13* MP0005025_abnormal_response_to2.76196947
14MP0005058_abnormal_lysosome_morphology2.72349430
15* MP0002452_abnormal_antigen_presenting2.66886678
16MP0001800_abnormal_humoral_immune2.62757518
17MP0005671_abnormal_response_to2.57451549
18MP0002723_abnormal_immune_serum2.51777926
19MP0003303_peritoneal_inflammation2.45117543
20MP0006082_CNS_inflammation2.40304670
21MP0004130_abnormal_muscle_cell2.35866888
22MP0003172_abnormal_lysosome_physiology2.31083086
23* MP0001819_abnormal_immune_cell2.28810155
24MP0003724_increased_susceptibility_to2.27950280
25MP0004859_abnormal_synaptic_plasticity2.27797068
26* MP0002420_abnormal_adaptive_immunity2.24843142
27MP0004270_analgesia2.19065672
28MP0005464_abnormal_platelet_physiology2.14239580
29MP0000751_myopathy2.09261418
30MP0001853_heart_inflammation2.00185228
31MP0002396_abnormal_hematopoietic_system1.96914827
32MP0005174_abnormal_tail_pigmentation1.95937369
33MP0002405_respiratory_system_inflammati1.91904872
34MP0009278_abnormal_bone_marrow1.90615062
35MP0002822_catalepsy1.89666347
36MP0002166_altered_tumor_susceptibility1.86896838
37MP0002006_tumorigenesis1.86715368
38MP0005423_abnormal_somatic_nervous1.85273398
39MP0001533_abnormal_skeleton_physiology1.81832272
40MP0002398_abnormal_bone_marrow1.80972285
41MP0000716_abnormal_immune_system1.76573354
42MP0000749_muscle_degeneration1.76551682
43MP0010155_abnormal_intestine_physiology1.75289012
44MP0001545_abnormal_hematopoietic_system1.73095359
45MP0005397_hematopoietic_system_phenotyp1.73095359
46MP0003635_abnormal_synaptic_transmissio1.72822340
47MP0000015_abnormal_ear_pigmentation1.71836595
48MP0004947_skin_inflammation1.70375655
49MP0001845_abnormal_inflammatory_respons1.66630103
50MP0002064_seizures1.66413623
51MP0002332_abnormal_exercise_endurance1.65706782
52MP0009333_abnormal_splenocyte_physiolog1.63916584
53MP0002106_abnormal_muscle_physiology1.60293254
54MP0000689_abnormal_spleen_morphology1.59178212
55MP0003879_abnormal_hair_cell1.58430163
56MP0001501_abnormal_sleep_pattern1.58057736
57MP0003448_altered_tumor_morphology1.55702935
58MP0004036_abnormal_muscle_relaxation1.55227535
59MP0009764_decreased_sensitivity_to1.54155220
60MP0000343_altered_response_to1.53312422
61MP0004808_abnormal_hematopoietic_stem1.52204083
62MP0002063_abnormal_learning/memory/cond1.49769188
63MP0009745_abnormal_behavioral_response1.47718939
64MP0008469_abnormal_protein_level1.47645858
65MP0002429_abnormal_blood_cell1.47435300
66MP0005645_abnormal_hypothalamus_physiol1.46791107
67MP0002837_dystrophic_cardiac_calcinosis1.43548702
68MP0001970_abnormal_pain_threshold1.41589301
69MP0002722_abnormal_immune_system1.40491501
70MP0002735_abnormal_chemical_nociception1.40035560
71MP0005310_abnormal_salivary_gland1.36783148
72MP0002733_abnormal_thermal_nociception1.36602866
73MP0002272_abnormal_nervous_system1.36489013
74MP0003690_abnormal_glial_cell1.35388729
75MP0003787_abnormal_imprinting1.34518153
76MP0000490_abnormal_crypts_of1.34035215
77MP0000858_altered_metastatic_potential1.34034527
78MP0002638_abnormal_pupillary_reflex1.32956442
79MP0002734_abnormal_mechanical_nocicepti1.32282417
80MP0000759_abnormal_skeletal_muscle1.32050248
81MP0002572_abnormal_emotion/affect_behav1.31912954
82MP0010307_abnormal_tumor_latency1.31862884
83MP0002998_abnormal_bone_remodeling1.30958818
84MP0000747_muscle_weakness1.30681606
85MP0005369_muscle_phenotype1.29774340
86MP0001873_stomach_inflammation1.29163644
87MP0005257_abnormal_intraocular_pressure1.25257293
88MP0003763_abnormal_thymus_physiology1.24199751
89MP0001986_abnormal_taste_sensitivity1.21758572
90MP0003329_amyloid_beta_deposits1.19087318
91MP0001502_abnormal_circadian_rhythm1.18600357
92MP0001486_abnormal_startle_reflex1.18065143
93MP0009046_muscle_twitch1.17166132
94MP0004142_abnormal_muscle_tone1.16632420
95MP0005620_abnormal_muscle_contractility1.16339364
96MP0003183_abnormal_peptide_metabolism1.16162027
97MP0005535_abnormal_body_temperature1.15582454
98MP0006276_abnormal_autonomic_nervous1.13746284
99MP0003880_abnormal_central_pattern1.13197225
100MP0005451_abnormal_body_composition1.12396028
101MP0008569_lethality_at_weaning1.10872672
102MP0003633_abnormal_nervous_system1.09506270
103MP0001851_eye_inflammation1.08629393
104MP0003191_abnormal_cellular_cholesterol1.07356187
105MP0002933_joint_inflammation1.07318215
106MP0000371_diluted_coat_color1.06958992
107MP0003045_fibrosis1.06652061
108MP0001968_abnormal_touch/_nociception1.06044841
109MP0002971_abnormal_brown_adipose1.05580940
110MP0002067_abnormal_sensory_capabilities1.03973189
111MP0000750_abnormal_muscle_regeneration1.03804111
112MP0004043_abnormal_pH_regulation1.02642616
113MP0003075_altered_response_to1.01433205
114MP0001440_abnormal_grooming_behavior1.00938517
115MP0002254_reproductive_system_inflammat0.99975609
116MP0004087_abnormal_muscle_fiber0.98935128
117MP0005390_skeleton_phenotype0.97464772
118MP0003566_abnormal_cell_adhesion0.96668485
119MP0002653_abnormal_ependyma_morphology0.96016562
120MP0008260_abnormal_autophagy0.95484126
121MP0009840_abnormal_foam_cell0.94986663
122MP0000703_abnormal_thymus_morphology0.93937330
123MP0008438_abnormal_cutaneous_collagen0.93854225
124MP0001984_abnormal_olfaction0.93807350
125MP0002909_abnormal_adrenal_gland0.93669590
126MP0003646_muscle_fatigue0.92511749
127MP0000767_abnormal_smooth_muscle0.90549408
128MP0003300_gastrointestinal_ulcer0.90389793
129MP0003091_abnormal_cell_migration0.89981997
130MP0005075_abnormal_melanosome_morpholog0.89732447
131MP0004924_abnormal_behavior0.88434804
132MP0005386_behavior/neurological_phenoty0.88434804
133MP0000013_abnormal_adipose_tissue0.88019561
134MP0002557_abnormal_social/conspecific_i0.87411586
135MP0000465_gastrointestinal_hemorrhage0.87318585
136MP0004885_abnormal_endolymph0.86679322
137MP0002693_abnormal_pancreas_physiology0.86577118
138MP0001348_abnormal_lacrimal_gland0.85926240
139MP0005646_abnormal_pituitary_gland0.85066543
140MP0002078_abnormal_glucose_homeostasis0.84697617
141MP0004782_abnormal_surfactant_physiolog0.84253517
142MP0001958_emphysema0.83781184
143MP0009763_increased_sensitivity_to0.82220557
144MP0008007_abnormal_cellular_replicative0.81779421
145MP0000230_abnormal_systemic_arterial0.80905724
146MP0008874_decreased_physiological_sensi0.80620649
147MP0005448_abnormal_energy_balance0.80114703
148MP0001905_abnormal_dopamine_level0.78402055
149MP0005076_abnormal_cell_differentiation0.77868499
150MP0003828_pulmonary_edema0.77672660
151MP0005166_decreased_susceptibility_to0.75432980
152MP0000249_abnormal_blood_vessel0.74045866
153MP0002019_abnormal_tumor_incidence0.71119854
154MP0003795_abnormal_bone_structure0.69241031
155MP0002095_abnormal_skin_pigmentation0.68754246
156MP0005023_abnormal_wound_healing0.68176958
157MP0002277_abnormal_respiratory_mucosa0.67946670
158MP0003866_abnormal_defecation0.67573632
159MP0005164_abnormal_response_to0.64850620
160MP0005621_abnormal_cell_physiology0.60010059
161MP0000604_amyloidosis0.58875760
162MP0002138_abnormal_hepatobiliary_system0.56172602
163MP0001915_intracranial_hemorrhage0.55925128
164MP0003453_abnormal_keratinocyte_physiol0.54457124
165MP0010352_gastrointestinal_tract_polyps0.54006775
166MP0003279_aneurysm0.53061278
167MP0005167_abnormal_blood-brain_barrier0.52644408

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.48528515
2Muscle fiber inclusion bodies (HP:0100299)6.04959496
3Recurrent bacterial skin infections (HP:0005406)6.04703930
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.73187115
5Nemaline bodies (HP:0003798)5.70930139
6Exercise-induced myalgia (HP:0003738)5.52492344
7Eczematoid dermatitis (HP:0000976)5.07447728
8Elevated erythrocyte sedimentation rate (HP:0003565)4.98588829
9Myositis (HP:0100614)4.94892189
10Type 1 muscle fiber predominance (HP:0003803)4.75351789
11Mediastinal lymphadenopathy (HP:0100721)4.40957987
12Orchitis (HP:0100796)4.33519343
13Abnormality of macrophages (HP:0004311)4.27344998
14Optic neuritis (HP:0100653)4.14191260
15Retrobulbar optic neuritis (HP:0100654)4.14191260
16Recurrent skin infections (HP:0001581)3.93148297
17Muscle hypertrophy of the lower extremities (HP:0008968)3.91231289
18Recurrent fungal infections (HP:0002841)3.85765659
19Myopathic facies (HP:0002058)3.82469501
20Increased cerebral lipofuscin (HP:0011813)3.80507751
21Recurrent gram-negative bacterial infections (HP:0005420)3.79790026
22Recurrent viral infections (HP:0004429)3.77741987
23Autoimmune thrombocytopenia (HP:0001973)3.77693280
24Exercise-induced muscle cramps (HP:0003710)3.73107868
25Chronic otitis media (HP:0000389)3.64502890
26Vacuolated lymphocytes (HP:0001922)3.54787016
27Increased neuronal autofluorescent lipopigment (HP:0002074)3.47221295
28Muscle fiber splitting (HP:0003555)3.30986075
29Difficulty running (HP:0009046)3.27520477
30Calf muscle hypertrophy (HP:0008981)3.27080588
31Distal arthrogryposis (HP:0005684)3.26991094
32Vasculitis (HP:0002633)3.25786646
33Gingivitis (HP:0000230)3.25208242
34Chronic mucocutaneous candidiasis (HP:0002728)3.23893873
35Recurrent cutaneous fungal infections (HP:0011370)3.23893873
36Abnormality of glycolipid metabolism (HP:0010969)3.11479712
37Abnormality of liposaccharide metabolism (HP:0010968)3.11479712
38Abnormality of glycosphingolipid metabolism (HP:0004343)3.11479712
39Prostate neoplasm (HP:0100787)3.05139859
40Basal ganglia calcification (HP:0002135)3.04292962
41Centrally nucleated skeletal muscle fibers (HP:0003687)3.01638050
42Systemic lupus erythematosus (HP:0002725)3.00911277
43EMG: myopathic abnormalities (HP:0003458)3.00391449
44Pulmonary infiltrates (HP:0002113)2.99519005
45Genetic anticipation (HP:0003743)2.99191330
46Obstructive lung disease (HP:0006536)2.99103874
47Chronic obstructive pulmonary disease (HP:0006510)2.99103874
48Frequent falls (HP:0002359)2.94860547
49Asymmetric septal hypertrophy (HP:0001670)2.94824508
50Ulnar deviation of the wrist (HP:0003049)2.92818895
51Periodontitis (HP:0000704)2.86265804
52Round ear (HP:0100830)2.84105861
53Diplopia (HP:0000651)2.83737408
54Abnormality of binocular vision (HP:0011514)2.83737408
55Cellulitis (HP:0100658)2.83409523
56Myoglobinuria (HP:0002913)2.82886408
57Meningitis (HP:0001287)2.77835491
58Stomatitis (HP:0010280)2.77720122
59Arterial thrombosis (HP:0004420)2.74955418
60Thrombocytosis (HP:0001894)2.70033613
61Abnormality of skeletal muscle fiber size (HP:0012084)2.61573732
62Rhabdomyolysis (HP:0003201)2.61153721
63Vertebral compression fractures (HP:0002953)2.59651995
64Hyporeflexia of lower limbs (HP:0002600)2.56899496
65Colitis (HP:0002583)2.56089881
66Leukocytosis (HP:0001974)2.54977346
67Osteomyelitis (HP:0002754)2.52606614
68Abnormality of the left ventricular outflow tract (HP:0011103)2.50812684
69Subaortic stenosis (HP:0001682)2.50812684
70Axonal loss (HP:0003447)2.50067444
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.47901571
72Progressive cerebellar ataxia (HP:0002073)2.47624159
73Myotonia (HP:0002486)2.46568774
74Hematochezia (HP:0002573)2.46537877
75Hemoptysis (HP:0002105)2.42076362
76Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.41575307
77Abnormality of the prostate (HP:0008775)2.40374754
78Hypergammaglobulinemia (HP:0010702)2.39820779
79Panhypogammaglobulinemia (HP:0003139)2.38605028
80Obstructive sleep apnea (HP:0002870)2.38411116
81Ankle clonus (HP:0011448)2.38264458
82Keratoconjunctivitis sicca (HP:0001097)2.37415152
83Abnormality of the calf musculature (HP:0001430)2.37279028
84Increased variability in muscle fiber diameter (HP:0003557)2.37158220
85Albinism (HP:0001022)2.36711616
86Agitation (HP:0000713)2.34361580
87Hemiplegia (HP:0002301)2.34182794
88Disinhibition (HP:0000734)2.34150605
89Inflammation of the large intestine (HP:0002037)2.32105325
90Mutism (HP:0002300)2.32001005
91Loss of speech (HP:0002371)2.31549900
92Recurrent pneumonia (HP:0006532)2.30674649
93Increased IgM level (HP:0003496)2.28119117
94Premature loss of primary teeth (HP:0006323)2.27926779
95Agnosia (HP:0010524)2.27065255
96Nasal polyposis (HP:0100582)2.25909603
97Pustule (HP:0200039)2.25131336
98Rimmed vacuoles (HP:0003805)2.22161415
99Hyperventilation (HP:0002883)2.21945712
100Agammaglobulinemia (HP:0004432)2.21869961
101Gastrointestinal inflammation (HP:0004386)2.21790832
102Recurrent lower respiratory tract infections (HP:0002783)2.21254793
103Muscle stiffness (HP:0003552)2.21154103
104Febrile seizures (HP:0002373)2.20033823
105Petechiae (HP:0000967)2.19723675
106Recurrent bronchitis (HP:0002837)2.19196164
107Interstitial pulmonary disease (HP:0006530)2.18526019
108Emphysema (HP:0002097)2.15826731
109Abnormality of the nasal mucosa (HP:0000433)2.15765013
110Gingival bleeding (HP:0000225)2.15175973
111Keratoconjunctivitis (HP:0001096)2.14265581
112Dysostosis multiplex (HP:0000943)2.13701933
113Pulmonary artery stenosis (HP:0004415)2.13512853
114EMG: neuropathic changes (HP:0003445)2.13028643
115Bundle branch block (HP:0011710)2.12359397
116Polyphagia (HP:0002591)2.11509392
117Glomerulonephritis (HP:0000099)2.08798825
118Gastrointestinal infarctions (HP:0005244)2.07819163
119Tetraparesis (HP:0002273)2.07377045
120Eosinophilia (HP:0001880)2.07364102
121Peritonitis (HP:0002586)2.07044155
122Epistaxis (HP:0000421)2.06583804
123Focal seizures (HP:0007359)2.04433720
124Abnormal eating behavior (HP:0100738)2.03138725
125Fetal akinesia sequence (HP:0001989)2.02941939
126Bone pain (HP:0002653)2.02424860
127Pathologic fracture (HP:0002756)2.01582308
128Abnormality of the fingertips (HP:0001211)2.00031011
129Abnormality of T cell physiology (HP:0011840)2.00014570
130Porencephaly (HP:0002132)1.99814024
131Ventricular fibrillation (HP:0001663)1.97914789
132Encephalitis (HP:0002383)1.97607463
133Chest pain (HP:0100749)1.97326141
134Hemiparesis (HP:0001269)1.96859021
135Focal motor seizures (HP:0011153)1.96827837
136Abnormality of polysaccharide metabolism (HP:0011012)1.96481281
137Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96481281
138Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96481281
139Neck muscle weakness (HP:0000467)1.96374365
140Abnormality of the pleura (HP:0002103)1.92033336
141Bruising susceptibility (HP:0000978)1.91078855
142Spontaneous hematomas (HP:0007420)1.90900355
143Absent frontal sinuses (HP:0002688)1.89974405
144Increased IgE level (HP:0003212)1.89494410
145Thyroiditis (HP:0100646)1.87893868
146Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86629206
147Visual hallucinations (HP:0002367)1.86401911
148Prolonged bleeding time (HP:0003010)1.86338675
149Hyperkalemia (HP:0002153)1.86272930
150Clumsiness (HP:0002312)1.85905971
151Poor head control (HP:0002421)1.85448071
152Abnormal EKG (HP:0003115)1.85225432
153Prolonged QT interval (HP:0001657)1.85204958
154Urinary bladder sphincter dysfunction (HP:0002839)1.84969536
155Spondylolisthesis (HP:0003302)1.84859843
156Granulocytopenia (HP:0001913)1.84446287
157Postural instability (HP:0002172)1.81206798
158Oligomenorrhea (HP:0000876)1.80558607
159Bulbar palsy (HP:0001283)1.79957155
160Absence seizures (HP:0002121)1.75231196
161Broad-based gait (HP:0002136)1.70043989
162Increased connective tissue (HP:0009025)1.69534624
163Absent phalangeal crease (HP:0006109)1.68906120
164Malignant hyperthermia (HP:0002047)1.68415859
165Congenital sensorineural hearing impairment (HP:0008527)1.66573631
166Rapidly progressive (HP:0003678)1.65958987
167Ketoacidosis (HP:0001993)1.65081687
168Papilledema (HP:0001085)1.64707542
169Slender build (HP:0001533)1.64405474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT3.85490371
2MAP3K143.82331177
3TYK23.66494858
4OBSCN3.61127046
5TBK13.55509521
6IRAK43.48697479
7IRAK33.36177634
8IKBKE3.14397605
9PHKG22.87963537
10PHKG12.87963537
11RIPK42.87815654
12JAK32.69608103
13MAP3K132.56944967
14IKBKB2.56120036
15MAP4K12.55569119
16BLK2.16599628
17PINK12.13443718
18MARK12.07578913
19PIM22.07201976
20JAK12.05182126
21TAOK32.03533448
22FRK2.03016347
23CSF1R1.98822321
24TNK21.98019120
25ERN11.85481460
26DAPK21.81926351
27CHUK1.70601767
28MAPK121.69926532
29FLT31.69757035
30TEC1.62016627
31TXK1.58147122
32RPS6KA41.57245152
33MAP3K71.57215455
34BTK1.38707054
35CAMKK11.37643325
36PRPF4B1.36494892
37MARK21.35267834
38SYK1.35219559
39TGFBR21.31573985
40ZAP701.31370268
41PIM11.30386097
42MAP2K31.29573416
43NEK91.28018974
44NTRK31.27666260
45NTRK21.26876265
46CASK1.26537660
47MAPK131.25616454
48NME21.24994428
49FES1.21771129
50HCK1.19750108
51MAP2K41.09924179
52MAP2K61.08380455
53LCK1.06906706
54CDC42BPA1.06558438
55CSK1.03472766
56TTN1.01777257
57LYN0.99192841
58DYRK1B0.97692001
59MAPK70.96098109
60CAMKK20.96010971
61INSRR0.95845908
62MAP4K20.95344533
63PKN10.95092250
64MATK0.91311891
65PRKD20.88323211
66SGK20.87950616
67CAMK40.86837496
68MAP3K10.82537520
69CDK190.82187285
70BMPR20.82072754
71TRPM70.82063966
72SGK2230.81543341
73SGK4940.81543341
74CAMK10.81489891
75CLK10.81143763
76MOS0.79147297
77RIPK10.78607890
78MAP3K60.77114458
79JAK20.76450174
80TYRO30.76399965
81SIK20.74656003
82YES10.74111852
83EIF2AK20.72825039
84PRKCH0.72391771
85MAP3K40.70695069
86SIK10.67964920
87PDK10.66908927
88STK110.66837177
89MAP3K50.66739968
90ARAF0.66069988
91SIK30.65853397
92BCKDK0.64559016
93SGK30.64538605
94MARK30.64199277
95STK40.63892300
96STK100.63558752
97EPHB10.61916885
98ABL10.61335522
99RPS6KA60.60163488
100CAMK1D0.59846362
101PAK60.59763074
102MAPK150.59636638
103PRKAA10.58726254
104TAOK20.57538692
105PRKCQ0.56801457
106MAP3K110.56749986
107CDK50.56145729
108UHMK10.56040223
109PRKAA20.55171443
110FGR0.55116304
111ABL20.54878718
112PIK3CG0.54834812
113NLK0.54782423
114MAPK40.53488198
115BMX0.53123127
116PRKCZ0.52872243
117PDPK10.52215057
118GRK70.50709703
119FGFR20.50109126
120STK30.49785441
121EPHA30.49458901
122PTK60.47392147
123EEF2K0.46816518
124PBK0.45223677
125MUSK0.44247899
126NUAK10.44104185
127TAOK10.43904799
128TRIB30.40081329
129MAP3K100.39866961
130MAPKAPK20.39674688
131EGFR0.39059071
132ITK0.38735497
133FGFR40.38326152
134IRAK10.37323993
135MAP3K30.36804967
136CDK120.36725084
137ATR0.36584804
138PAK40.36163810
139RPS6KC10.35820397
140RPS6KL10.35820397
141PRKCD0.35740212
142FGFR30.34311181
143MAPKAPK30.34276995
144TGFBR10.34021921
145PKN20.33781041
146PLK40.33337198
147NEK20.33323510
148HIPK20.30170005
149PRKG20.30033356
150ADRBK20.29619156
151IRAK20.29591246
152RPS6KA20.29011836
153CDK60.27870881
154LRRK20.27565498

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.07277116
2Toll-like receptor signaling pathway_Homo sapiens_hsa046202.75408539
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.68111511
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.67114073
5RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.43946309
6Measles_Homo sapiens_hsa051622.36724256
7Osteoclast differentiation_Homo sapiens_hsa043802.36478453
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.19087447
9Influenza A_Homo sapiens_hsa051642.07356065
10Malaria_Homo sapiens_hsa051442.05584602
11Allograft rejection_Homo sapiens_hsa053302.03372509
12TNF signaling pathway_Homo sapiens_hsa046682.01147695
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95077366
14Herpes simplex infection_Homo sapiens_hsa051681.92144843
15Tuberculosis_Homo sapiens_hsa051521.90822763
16Pertussis_Homo sapiens_hsa051331.88235666
17B cell receptor signaling pathway_Homo sapiens_hsa046621.86416653
18Other glycan degradation_Homo sapiens_hsa005111.84677252
19Legionellosis_Homo sapiens_hsa051341.83413032
20Graft-versus-host disease_Homo sapiens_hsa053321.78367440
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.77516634
22Toxoplasmosis_Homo sapiens_hsa051451.75010030
23Staphylococcus aureus infection_Homo sapiens_hsa051501.70676926
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.68252347
25Apoptosis_Homo sapiens_hsa042101.61387052
26Insulin secretion_Homo sapiens_hsa049111.60486662
27Primary immunodeficiency_Homo sapiens_hsa053401.59654234
28Antigen processing and presentation_Homo sapiens_hsa046121.54536212
29Circadian entrainment_Homo sapiens_hsa047131.51691573
30Lysosome_Homo sapiens_hsa041421.50367021
31Oxytocin signaling pathway_Homo sapiens_hsa049211.49997148
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.49272551
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46772600
34Shigellosis_Homo sapiens_hsa051311.45561304
35Hematopoietic cell lineage_Homo sapiens_hsa046401.44704090
36Rheumatoid arthritis_Homo sapiens_hsa053231.42621004
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38514607
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35620464
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34328684
40Hepatitis B_Homo sapiens_hsa051611.34087175
41Salmonella infection_Homo sapiens_hsa051321.32727563
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31993058
43Cholinergic synapse_Homo sapiens_hsa047251.28423818
44Calcium signaling pathway_Homo sapiens_hsa040201.27777432
45Morphine addiction_Homo sapiens_hsa050321.27755030
46Nicotine addiction_Homo sapiens_hsa050331.26122398
47Renin secretion_Homo sapiens_hsa049241.25585787
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.24835032
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24041980
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23724619
51Carbohydrate digestion and absorption_Homo sapiens_hsa049731.23600580
52Glutamatergic synapse_Homo sapiens_hsa047241.23540961
53Chemokine signaling pathway_Homo sapiens_hsa040621.23334682
54Asthma_Homo sapiens_hsa053101.23181336
55Gastric acid secretion_Homo sapiens_hsa049711.21958542
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21217215
57GABAergic synapse_Homo sapiens_hsa047271.15865759
58Phagosome_Homo sapiens_hsa041451.15710683
59Acute myeloid leukemia_Homo sapiens_hsa052211.15594539
60Hepatitis C_Homo sapiens_hsa051601.15471095
61GnRH signaling pathway_Homo sapiens_hsa049121.15361670
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09167721
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09143047
64Long-term depression_Homo sapiens_hsa047301.08483267
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08128505
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07543062
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07491228
68Synaptic vesicle cycle_Homo sapiens_hsa047211.06684895
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06536851
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05281389
71Dorso-ventral axis formation_Homo sapiens_hsa043201.04814723
72African trypanosomiasis_Homo sapiens_hsa051431.04191428
73Salivary secretion_Homo sapiens_hsa049701.03537136
74Long-term potentiation_Homo sapiens_hsa047201.01678643
75Chronic myeloid leukemia_Homo sapiens_hsa052201.01425654
76Viral myocarditis_Homo sapiens_hsa054160.98790928
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.98681042
78Dilated cardiomyopathy_Homo sapiens_hsa054140.96795431
79Dopaminergic synapse_Homo sapiens_hsa047280.96263468
80Pancreatic cancer_Homo sapiens_hsa052120.91725887
81Circadian rhythm_Homo sapiens_hsa047100.90662160
82Epstein-Barr virus infection_Homo sapiens_hsa051690.89956537
83Amphetamine addiction_Homo sapiens_hsa050310.89787739
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89093979
85Base excision repair_Homo sapiens_hsa034100.88437520
86Cocaine addiction_Homo sapiens_hsa050300.88307188
87cAMP signaling pathway_Homo sapiens_hsa040240.88093621
88Type I diabetes mellitus_Homo sapiens_hsa049400.87832405
89Small cell lung cancer_Homo sapiens_hsa052220.87298656
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86773325
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.86454230
92Autoimmune thyroid disease_Homo sapiens_hsa053200.86445658
93Collecting duct acid secretion_Homo sapiens_hsa049660.83882125
94Prolactin signaling pathway_Homo sapiens_hsa049170.83286469
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82604013
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82018996
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79776281
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78600444
99T cell receptor signaling pathway_Homo sapiens_hsa046600.78134579
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.76697686
101Amoebiasis_Homo sapiens_hsa051460.76555890
102Cardiac muscle contraction_Homo sapiens_hsa042600.76433838
103Ovarian steroidogenesis_Homo sapiens_hsa049130.76299580
104Platelet activation_Homo sapiens_hsa046110.74640954
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.74050703
106Serotonergic synapse_Homo sapiens_hsa047260.73790185
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73007624
108Estrogen signaling pathway_Homo sapiens_hsa049150.71676935
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70922867
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69648148
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68129798
112Insulin signaling pathway_Homo sapiens_hsa049100.67866910
113Non-homologous end-joining_Homo sapiens_hsa034500.66103865
114Regulation of autophagy_Homo sapiens_hsa041400.65600206
115Glucagon signaling pathway_Homo sapiens_hsa049220.65472253
116p53 signaling pathway_Homo sapiens_hsa041150.65009003
117Notch signaling pathway_Homo sapiens_hsa043300.64896196
118Homologous recombination_Homo sapiens_hsa034400.64478195
119Caffeine metabolism_Homo sapiens_hsa002320.63030534
120HTLV-I infection_Homo sapiens_hsa051660.60598241
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60140362
122mTOR signaling pathway_Homo sapiens_hsa041500.59249559
123Viral carcinogenesis_Homo sapiens_hsa052030.59248359
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.59224241
125DNA replication_Homo sapiens_hsa030300.57513777
126HIF-1 signaling pathway_Homo sapiens_hsa040660.56864370
127Taste transduction_Homo sapiens_hsa047420.56686686
128ABC transporters_Homo sapiens_hsa020100.56635054
129Phototransduction_Homo sapiens_hsa047440.56010970
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48905728
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44207667
132MicroRNAs in cancer_Homo sapiens_hsa052060.42298455
133VEGF signaling pathway_Homo sapiens_hsa043700.38281071
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.38046808
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36565771
136Fanconi anemia pathway_Homo sapiens_hsa034600.36265427
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.35987454
138Colorectal cancer_Homo sapiens_hsa052100.35489556
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34525916
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33103157
141Type II diabetes mellitus_Homo sapiens_hsa049300.31335652
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28841888
143FoxO signaling pathway_Homo sapiens_hsa040680.28634800
144MAPK signaling pathway_Homo sapiens_hsa040100.26036733
145Insulin resistance_Homo sapiens_hsa049310.25736673
146Sphingolipid metabolism_Homo sapiens_hsa006000.25709991
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25629993
148Non-small cell lung cancer_Homo sapiens_hsa052230.24798872
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23970673
150Proteoglycans in cancer_Homo sapiens_hsa052050.21784510
151Mismatch repair_Homo sapiens_hsa034300.20978263
152Cell cycle_Homo sapiens_hsa041100.20249014

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