RASA4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcoplasmic reticulum calcium ion transport (GO:0070296)5.54582680
2skeletal muscle contraction (GO:0003009)5.07876977
3muscle filament sliding (GO:0030049)4.90330035
4actin-myosin filament sliding (GO:0033275)4.90330035
5regulation of skeletal muscle contraction (GO:0014819)4.81216152
6actin-mediated cell contraction (GO:0070252)3.80826982
7creatine metabolic process (GO:0006600)3.71520634
8striated muscle contraction (GO:0006941)3.43298954
9myofibril assembly (GO:0030239)3.35266270
10response to muscle activity (GO:0014850)3.26799540
11negative regulation of erythrocyte differentiation (GO:0045647)3.23600930
12mannose metabolic process (GO:0006013)3.20705148
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.13714551
14negative regulation of cell killing (GO:0031342)3.13047260
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.13047260
16skeletal muscle adaptation (GO:0043501)3.09145114
17actin filament-based movement (GO:0030048)3.07912677
18regulation of relaxation of muscle (GO:1901077)3.06164303
19response to inactivity (GO:0014854)2.97548029
20skeletal muscle fiber development (GO:0048741)2.94223001
21positive regulation of gamma-delta T cell activation (GO:0046645)2.79281973
22germinal center formation (GO:0002467)2.74270515
23negative regulation of interleukin-12 production (GO:0032695)2.68965660
24regulation of gamma-delta T cell activation (GO:0046643)2.66817888
25macrophage activation involved in immune response (GO:0002281)2.66051797
26regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.64741165
27glycogen catabolic process (GO:0005980)2.58685920
28myotube cell development (GO:0014904)2.55390947
29negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.54600531
30neuronal action potential propagation (GO:0019227)2.53323771
31muscle contraction (GO:0006936)2.52543661
32cardiac muscle contraction (GO:0060048)2.51158828
33positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.50283971
34macroautophagy (GO:0016236)2.50006220
35response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.49582699
36glucan catabolic process (GO:0009251)2.47113524
37response to peptidoglycan (GO:0032494)2.41473473
38plasma membrane repair (GO:0001778)2.38224485
39cellular polysaccharide catabolic process (GO:0044247)2.38032900
40muscle system process (GO:0003012)2.37335327
41immunoglobulin mediated immune response (GO:0016064)2.33854506
42synaptic transmission, cholinergic (GO:0007271)2.31381816
43muscle adaptation (GO:0043500)2.28590108
44regulation of gamma-delta T cell differentiation (GO:0045586)2.25541261
45striated muscle adaptation (GO:0014888)2.25513755
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.24161647
47regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.23944775
48striated muscle atrophy (GO:0014891)2.23178549
49fructose metabolic process (GO:0006000)2.22585640
50positive regulation of antigen processing and presentation (GO:0002579)2.21987752
51response to muramyl dipeptide (GO:0032495)2.20941418
52sarcomere organization (GO:0045214)2.19380975
53modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.18611179
54positive regulation by organism of defense response of other organism involved in symbiotic interact2.18611179
55modulation by symbiont of host immune response (GO:0052553)2.18611179
56positive regulation by symbiont of host defense response (GO:0052509)2.18611179
57modulation by symbiont of host defense response (GO:0052031)2.18611179
58modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.18611179
59response to activity (GO:0014823)2.17550055
60polysaccharide catabolic process (GO:0000272)2.17247275
61neuromuscular synaptic transmission (GO:0007274)2.16132865
62interferon-gamma-mediated signaling pathway (GO:0060333)2.13707969
63positive regulation of heat generation (GO:0031652)2.13291378
64NIK/NF-kappaB signaling (GO:0038061)2.11501487
65cellular response to nicotine (GO:0071316)2.10360669
66amino sugar catabolic process (GO:0046348)2.08730950
67muscle fiber development (GO:0048747)2.08367954
68muscle cell cellular homeostasis (GO:0046716)2.07718149
69lysosome organization (GO:0007040)2.06409596
70lytic vacuole organization (GO:0080171)2.06409596
71T-helper 1 type immune response (GO:0042088)2.06164981
72phosphatidylglycerol biosynthetic process (GO:0006655)2.05042273
73cardiac myofibril assembly (GO:0055003)2.04860740
74regulation of ARF GTPase activity (GO:0032312)2.04859278
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.04647427
76regulation of mast cell degranulation (GO:0043304)2.04623706
77virion attachment to host cell (GO:0019062)2.04214156
78adhesion of symbiont to host cell (GO:0044650)2.04214156
79negative regulation of granulocyte differentiation (GO:0030853)2.01965423
80negative regulation of cAMP-mediated signaling (GO:0043951)2.01938848
81muscle hypertrophy (GO:0014896)2.01760214
82skeletal muscle tissue development (GO:0007519)2.01407101
83positive regulation of myotube differentiation (GO:0010831)2.00809702
84positive regulation of mast cell activation (GO:0033005)2.00731803
85macrophage activation (GO:0042116)1.99447792
86regulation of mast cell activation involved in immune response (GO:0033006)1.99002050
87interferon-gamma production (GO:0032609)1.98423224
882-oxoglutarate metabolic process (GO:0006103)1.97818244
89regulation of antigen processing and presentation (GO:0002577)1.97730995
90regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)1.96189425
91N-acetylneuraminate metabolic process (GO:0006054)1.96137963
92regulation of cholesterol storage (GO:0010885)1.95962541
93negative regulation of cytokine production involved in immune response (GO:0002719)1.95210924
94nitric oxide mediated signal transduction (GO:0007263)1.93913592
95regulation of interferon-beta biosynthetic process (GO:0045357)1.91918412
96cardiac muscle hypertrophy (GO:0003300)1.89951831
97neutrophil activation involved in immune response (GO:0002283)1.89923126
98regulation of dendritic cell antigen processing and presentation (GO:0002604)1.89578362
99regulation of necroptotic process (GO:0060544)1.89063439
100muscle organ development (GO:0007517)1.87910910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.79941824
2EZH2_22144423_ChIP-Seq_EOC_Human3.38959838
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.94248825
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.38666238
5DROSHA_22980978_ChIP-Seq_HELA_Human2.35064110
6LXR_22292898_ChIP-Seq_THP-1_Human2.14577780
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00128902
8KDM2B_26808549_Chip-Seq_SUP-B15_Human1.99919787
9IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95282240
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79262365
11VDR_21846776_ChIP-Seq_THP-1_Human1.75095040
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72251803
13IRF8_21731497_ChIP-ChIP_J774_Mouse1.69671293
14KDM2B_26808549_Chip-Seq_DND41_Human1.66639120
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63500967
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62935407
17PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.59871973
18E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58009437
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56977276
20DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52804314
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51495005
22BCL6_27268052_Chip-Seq_Bcells_Human1.48843890
23SPI1_23127762_ChIP-Seq_K562_Human1.47383246
24IRF8_27001747_Chip-Seq_BMDM_Mouse1.47054999
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46487811
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.40613096
27CTCF_27219007_Chip-Seq_Bcells_Human1.40413601
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39227407
29SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38651421
30SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37573153
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36821467
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36391935
33VDR_24763502_ChIP-Seq_THP-1_Human1.36140687
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36048341
35GATA1_19941827_ChIP-Seq_MEL_Mouse1.35485056
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35043645
37GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34841774
38VDR_24787735_ChIP-Seq_THP-1_Human1.34608583
39TCF7_22412390_ChIP-Seq_EML_Mouse1.32842141
40BCOR_27268052_Chip-Seq_Bcells_Human1.31626449
41P68_20966046_ChIP-Seq_HELA_Human1.31217333
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30253476
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30014353
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27262405
45RUNX_20019798_ChIP-Seq_JUKART_Human1.22520616
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22518738
47SMC4_20622854_ChIP-Seq_HELA_Human1.19422477
48SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19184262
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.19044100
50KDM2B_26808549_Chip-Seq_K562_Human1.18491475
51SA1_27219007_Chip-Seq_ERYTHROID_Human1.17958206
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17132207
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16979416
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16426367
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14525976
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14159360
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13561566
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.13075860
59STAT1_20625510_ChIP-Seq_HELA_Human1.12692148
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11558799
61SA1_27219007_Chip-Seq_Bcells_Human1.11195007
62SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10769979
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10126594
64OCT4_19829295_ChIP-Seq_ESCs_Human1.09693151
65SCL_19346495_ChIP-Seq_HPC-7_Human1.07677828
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.06852179
67MAF_26560356_Chip-Seq_TH2_Human1.06548732
68MAF_26560356_Chip-Seq_TH1_Human1.06463650
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05541154
70REST_18959480_ChIP-ChIP_MESCs_Mouse1.05502579
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.05380290
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04157228
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04014069
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02815829
75E2F1_20622854_ChIP-Seq_HELA_Human1.00589042
76REST_21632747_ChIP-Seq_MESCs_Mouse0.99416302
77CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98991418
78SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97675438
79CTCF_26484167_Chip-Seq_Bcells_Mouse0.97540992
80RUNX1_22412390_ChIP-Seq_EML_Mouse0.96524906
81NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95063655
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94206232
83RNF2_27304074_Chip-Seq_ESCs_Mouse0.93626990
84UTX_26944678_Chip-Seq_JUKART_Human0.93430993
85KDM2B_26808549_Chip-Seq_JURKAT_Human0.93221133
86TET1_21451524_ChIP-Seq_MESCs_Mouse0.92474687
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92367048
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91207163
89OCT4_20526341_ChIP-Seq_ESCs_Human0.91136207
90FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89574118
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89058766
92PHF8_20622854_ChIP-Seq_HELA_Human0.88741655
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87719552
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87464188
95RARB_27405468_Chip-Seq_BRAIN_Mouse0.87392592
96FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86038460
97KLF4_19829295_ChIP-Seq_ESCs_Human0.85839403
98RAD21_21589869_ChIP-Seq_MESCs_Mouse0.85598238
99TP63_22573176_ChIP-Seq_HFKS_Human0.85580126
100SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85521881

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.02700702
2MP0004145_abnormal_muscle_electrophysio3.96183885
3MP0000751_myopathy3.07468412
4MP0000749_muscle_degeneration2.99826602
5MP0005058_abnormal_lysosome_morphology2.73295320
6MP0005451_abnormal_body_composition2.65376265
7MP0004510_myositis2.53594406
8MP0003303_peritoneal_inflammation2.40531131
9MP0009840_abnormal_foam_cell2.33719666
10MP0004036_abnormal_muscle_relaxation2.27868185
11MP0004130_abnormal_muscle_cell2.18975221
12MP0002332_abnormal_exercise_endurance2.17979094
13MP0002106_abnormal_muscle_physiology2.05244011
14MP0005167_abnormal_blood-brain_barrier2.00880397
15MP0000747_muscle_weakness2.00789101
16MP0003172_abnormal_lysosome_physiology1.98809116
17MP0003724_increased_susceptibility_to1.96229982
18MP0003436_decreased_susceptibility_to1.93980026
19MP0002837_dystrophic_cardiac_calcinosis1.93651096
20MP0000759_abnormal_skeletal_muscle1.87291185
21MP0004270_analgesia1.74780438
22MP0005369_muscle_phenotype1.68266453
23MP0005387_immune_system_phenotype1.65778705
24MP0001790_abnormal_immune_system1.65778705
25MP0002148_abnormal_hypersensitivity_rea1.65553731
26MP0004087_abnormal_muscle_fiber1.53019261
27MP0005620_abnormal_muscle_contractility1.52777355
28MP0000750_abnormal_muscle_regeneration1.52381530
29MP0005671_abnormal_response_to1.51345497
30MP0002419_abnormal_innate_immunity1.49904243
31MP0006082_CNS_inflammation1.49575684
32MP0003879_abnormal_hair_cell1.48098720
33MP0003690_abnormal_glial_cell1.45764035
34MP0005000_abnormal_immune_tolerance1.45057960
35MP0009278_abnormal_bone_marrow1.44351353
36MP0002822_catalepsy1.41414376
37MP0005025_abnormal_response_to1.38531860
38MP0002269_muscular_atrophy1.36670576
39MP0003075_altered_response_to1.36169490
40MP0000685_abnormal_immune_system1.31379906
41MP0001835_abnormal_antigen_presentation1.24640941
42MP0002971_abnormal_brown_adipose1.23944874
43MP0000013_abnormal_adipose_tissue1.23864497
44MP0001800_abnormal_humoral_immune1.23710545
45MP0009785_altered_susceptibility_to1.23583352
46MP0000343_altered_response_to1.21313056
47MP0000604_amyloidosis1.19188982
48MP0002723_abnormal_immune_serum1.17898599
49MP0003300_gastrointestinal_ulcer1.14560007
50MP0002452_abnormal_antigen_presenting1.14165496
51MP0006036_abnormal_mitochondrial_physio1.12022271
52MP0003183_abnormal_peptide_metabolism1.11691026
53MP0009764_decreased_sensitivity_to1.10796866
54MP0001533_abnormal_skeleton_physiology1.10616001
55MP0004859_abnormal_synaptic_plasticity1.10159446
56MP0005330_cardiomyopathy1.09937555
57MP0002998_abnormal_bone_remodeling1.06629664
58MP0005535_abnormal_body_temperature1.06003648
59MP0002138_abnormal_hepatobiliary_system1.04058542
60MP0008004_abnormal_stomach_pH1.03744534
61MP0005166_decreased_susceptibility_to1.03178350
62MP0002420_abnormal_adaptive_immunity1.02028170
63MP0002972_abnormal_cardiac_muscle1.01321879
64MP0004084_abnormal_cardiac_muscle1.00883226
65MP0001501_abnormal_sleep_pattern1.00700553
66MP0001819_abnormal_immune_cell1.00540906
67MP0005266_abnormal_metabolism0.99681160
68MP0003329_amyloid_beta_deposits0.98553482
69MP0002139_abnormal_hepatobiliary_system0.95839307
70MP0002638_abnormal_pupillary_reflex0.95694753
71MP0005310_abnormal_salivary_gland0.93875899
72MP0002254_reproductive_system_inflammat0.89968728
73MP0004043_abnormal_pH_regulation0.89600798
74MP0008874_decreased_physiological_sensi0.88032694
75MP0002078_abnormal_glucose_homeostasis0.87792440
76MP0002933_joint_inflammation0.87455860
77MP0003045_fibrosis0.87236508
78MP0000733_abnormal_muscle_development0.87216568
79MP0008469_abnormal_protein_level0.86798743
80MP0002108_abnormal_muscle_morphology0.86699602
81MP0005375_adipose_tissue_phenotype0.86479285
82MP0001845_abnormal_inflammatory_respons0.86451777
83MP0002693_abnormal_pancreas_physiology0.86405559
84MP0004233_abnormal_muscle_weight0.84986880
85MP0001502_abnormal_circadian_rhythm0.84115018
86MP0002064_seizures0.83623956
87MP0003279_aneurysm0.80074591
88MP0003633_abnormal_nervous_system0.79105164
89MP0000230_abnormal_systemic_arterial0.78205457
90MP0003806_abnormal_nucleotide_metabolis0.77530051
91MP0003635_abnormal_synaptic_transmissio0.76521062
92MP0005448_abnormal_energy_balance0.75864793
93MP0005595_abnormal_vascular_smooth0.75409120
94MP0005397_hematopoietic_system_phenotyp0.75234982
95MP0001545_abnormal_hematopoietic_system0.75234982
96MP0002127_abnormal_cardiovascular_syste0.74670940
97MP0004484_altered_response_of0.74479992
98MP0010155_abnormal_intestine_physiology0.72094285
99MP0000920_abnormal_myelination0.70834314
100MP0001970_abnormal_pain_threshold0.70808713

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.22714590
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.94881856
3Nemaline bodies (HP:0003798)6.92051051
4Exercise-induced myalgia (HP:0003738)6.49376161
5Type 1 muscle fiber predominance (HP:0003803)5.73589611
6Exercise-induced muscle cramps (HP:0003710)4.68471644
7Muscle hypertrophy of the lower extremities (HP:0008968)4.64769636
8Myopathic facies (HP:0002058)4.55429664
9Muscle fiber splitting (HP:0003555)4.14863016
10Calf muscle hypertrophy (HP:0008981)3.94994642
11Distal arthrogryposis (HP:0005684)3.88102208
12EMG: myopathic abnormalities (HP:0003458)3.79099686
13Asymmetric septal hypertrophy (HP:0001670)3.75107956
14Centrally nucleated skeletal muscle fibers (HP:0003687)3.74073406
15Round ear (HP:0100830)3.69438948
16Abnormality of liposaccharide metabolism (HP:0010968)3.64269706
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.64269706
18Abnormality of glycolipid metabolism (HP:0010969)3.64269706
19Myoglobinuria (HP:0002913)3.50317012
20Frequent falls (HP:0002359)3.48635848
21Rhabdomyolysis (HP:0003201)3.44992220
22Abnormality of skeletal muscle fiber size (HP:0012084)3.32874079
23Ulnar deviation of the wrist (HP:0003049)3.29365254
24Hyporeflexia of lower limbs (HP:0002600)3.29107470
25Difficulty running (HP:0009046)3.18262432
26Abnormality of the calf musculature (HP:0001430)3.11123938
27Increased connective tissue (HP:0009025)3.02200381
28Increased variability in muscle fiber diameter (HP:0003557)2.99987347
29Rimmed vacuoles (HP:0003805)2.92510116
30Muscle stiffness (HP:0003552)2.88928582
31Dysostosis multiplex (HP:0000943)2.87783765
32Neck muscle weakness (HP:0000467)2.72867758
33Subaortic stenosis (HP:0001682)2.66768956
34Abnormality of the left ventricular outflow tract (HP:0011103)2.66768956
35Bulbar palsy (HP:0001283)2.65765827
36Increased cerebral lipofuscin (HP:0011813)2.48443976
37Fetal akinesia sequence (HP:0001989)2.46148063
38EMG: neuropathic changes (HP:0003445)2.43545657
39Mutism (HP:0002300)2.41710330
40Systemic lupus erythematosus (HP:0002725)2.39249841
41Myotonia (HP:0002486)2.38935161
42Vacuolated lymphocytes (HP:0001922)2.38763886
43Malignant hyperthermia (HP:0002047)2.38313371
44Distal lower limb muscle weakness (HP:0009053)2.38305028
45Abnormality of mucopolysaccharide metabolism (HP:0011020)2.34495855
46Abnormality of polysaccharide metabolism (HP:0011012)2.34495855
47Abnormality of glycosaminoglycan metabolism (HP:0004371)2.34495855
48Axonal loss (HP:0003447)2.32992830
49Loss of speech (HP:0002371)2.32075526
50Bundle branch block (HP:0011710)2.15538894
51Eczematoid dermatitis (HP:0000976)2.14822613
52Distal lower limb amyotrophy (HP:0008944)2.14058951
53Abnormality of macrophages (HP:0004311)2.13660348
54Difficulty climbing stairs (HP:0003551)2.13603260
55Mucopolysacchariduria (HP:0008155)2.11021405
56Urinary glycosaminoglycan excretion (HP:0003541)2.11021405
57Disinhibition (HP:0000734)2.11005264
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.09028772
59Increased neuronal autofluorescent lipopigment (HP:0002074)2.07428005
60Myositis (HP:0100614)2.02877409
61Nuclear cataract (HP:0100018)1.99842706
62J-shaped sella turcica (HP:0002680)1.99228592
63Generalized muscle weakness (HP:0003324)1.99164532
64Obstructive sleep apnea (HP:0002870)1.98923756
65Calcaneovalgus deformity (HP:0001848)1.98554376
66Sudden death (HP:0001699)1.97344750
67Abnormality of lateral ventricle (HP:0030047)1.96287781
68Stomatitis (HP:0010280)1.94999999
69Areflexia of lower limbs (HP:0002522)1.94874539
70Absent phalangeal crease (HP:0006109)1.93007623
71Slender build (HP:0001533)1.92688153
72Ventricular fibrillation (HP:0001663)1.92035298
73Spontaneous hematomas (HP:0007420)1.91649217
74Orchitis (HP:0100796)1.87956691
75Mildly elevated creatine phosphokinase (HP:0008180)1.83639486
76Scapular winging (HP:0003691)1.80535432
77Optic neuritis (HP:0100653)1.79868647
78Retrobulbar optic neuritis (HP:0100654)1.79868647
79Rapidly progressive (HP:0003678)1.79264146
80Stridor (HP:0010307)1.77543071
81Gowers sign (HP:0003391)1.77436502
82Waddling gait (HP:0002515)1.77013093
83Easy fatigability (HP:0003388)1.75463957
84Ankle clonus (HP:0011448)1.74856216
85Hematochezia (HP:0002573)1.74819828
86Neurofibrillary tangles (HP:0002185)1.73844714
87Nonprogressive disorder (HP:0003680)1.73199510
88Prolonged QT interval (HP:0001657)1.71907129
89Recurrent bacterial skin infections (HP:0005406)1.71641716
90Mediastinal lymphadenopathy (HP:0100721)1.71192631
91Clumsiness (HP:0002312)1.70238209
92Hyperkalemia (HP:0002153)1.69136098
93Abnormality of the foot musculature (HP:0001436)1.67449278
94Deformed tarsal bones (HP:0008119)1.66873392
95Agitation (HP:0000713)1.66763775
96Muscular dystrophy (HP:0003560)1.66502381
97Recurrent abscess formation (HP:0002722)1.64630797
98Weak cry (HP:0001612)1.64077948
99Spinal rigidity (HP:0003306)1.63950130
100Foot dorsiflexor weakness (HP:0009027)1.63884639

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.87840056
2PHKG13.46658879
3PHKG23.46658879
4TTN3.03868402
5PINK12.53038806
6MAP2K31.99237036
7MAP2K61.97341876
8SIK21.97293356
9TNK21.90014108
10MAP4K11.84226976
11TAOK21.80280942
12MAPK121.66547538
13BLK1.64972745
14TAOK11.50604045
15TBK11.46825117
16SIK11.44646230
17DAPK21.44361745
18MAP3K71.43991655
19MAP3K111.39832679
20ERN11.38463268
21TAOK31.35750790
22MARK11.32685310
23PRPF4B1.24288128
24RIPK11.22443636
25PIK3CG1.17551067
26MAP3K11.16909035
27MARK21.15677070
28EPHA31.13321383
29PRKD21.12296501
30RIPK41.11583914
31DYRK1B1.06449330
32MAP3K131.05829964
33TYK21.05451912
34TRIB31.05090345
35CDC42BPA1.01788646
36FRK0.99888036
37EPHB10.99331987
38MARK30.96195861
39FES0.96094213
40MAPK70.93520832
41CSF1R0.92346347
42MAP3K140.91881510
43ADRBK20.89248877
44MAP2K40.88677417
45DDR20.87120976
46KIT0.86680344
47IKBKB0.86007696
48TRPM70.84998501
49CSK0.84259168
50BCKDK0.82618380
51SYK0.79485444
52NME10.78777182
53PKN10.78063737
54MATK0.75216130
55IKBKE0.74955776
56MAP3K30.73081112
57TGFBR20.72862047
58MAPK130.72431627
59MAPK40.71953653
60MAP4K20.71624495
61HIPK20.70591078
62MAPKAPK30.70366014
63IRAK40.69535272
64GRK70.69301672
65RPS6KA20.67671484
66MUSK0.65304714
67PRKAA20.65074873
68BTK0.64937067
69JAK30.64479851
70MOS0.63841898
71ZAP700.61635746
72IRAK30.61616136
73EEF2K0.61077441
74RPS6KC10.60702287
75RPS6KL10.60702287
76NTRK30.59625285
77PRKAA10.58907974
78PDPK10.58836594
79CHUK0.58684138
80MAP3K60.58283178
81PDK10.57830004
82CAMK40.57628408
83NTRK20.56651680
84RPS6KA60.56628978
85FGR0.54821465
86PRKCH0.53858957
87HCK0.53680531
88JAK10.52562567
89LYN0.49914852
90CAMK10.48615262
91JAK20.47842193
92CAMKK10.47530647
93CAMK2G0.47358453
94LCK0.43901107
95SGK20.42533246
96MAPK110.42506129
97ICK0.42334634
98SGK30.41084241
99PRKCQ0.39661809
100TXK0.39380700

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.92204424
2Staphylococcus aureus infection_Homo sapiens_hsa051501.87401024
3Osteoclast differentiation_Homo sapiens_hsa043801.86819359
4Lysosome_Homo sapiens_hsa041421.86421650
5Glycosaminoglycan degradation_Homo sapiens_hsa005311.80147675
6Type I diabetes mellitus_Homo sapiens_hsa049401.68754675
7Allograft rejection_Homo sapiens_hsa053301.66804161
8Intestinal immune network for IgA production_Homo sapiens_hsa046721.64057431
9Asthma_Homo sapiens_hsa053101.61011978
10Leishmaniasis_Homo sapiens_hsa051401.49583200
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45733080
12Tuberculosis_Homo sapiens_hsa051521.44650569
13Dilated cardiomyopathy_Homo sapiens_hsa054141.43674672
14Oxytocin signaling pathway_Homo sapiens_hsa049211.40236213
15Rheumatoid arthritis_Homo sapiens_hsa053231.38908263
16Autoimmune thyroid disease_Homo sapiens_hsa053201.37859708
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36420386
18Graft-versus-host disease_Homo sapiens_hsa053321.35839662
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31283854
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29204029
21Calcium signaling pathway_Homo sapiens_hsa040201.18330391
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17442445
23Type II diabetes mellitus_Homo sapiens_hsa049301.16388793
24B cell receptor signaling pathway_Homo sapiens_hsa046621.15121232
25GnRH signaling pathway_Homo sapiens_hsa049121.14605921
26Renin secretion_Homo sapiens_hsa049241.12493004
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.12146390
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11541389
29Insulin secretion_Homo sapiens_hsa049111.10335854
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10209855
31Circadian rhythm_Homo sapiens_hsa047101.07659943
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07443788
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06423655
34Viral myocarditis_Homo sapiens_hsa054161.03166961
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02391630
36TNF signaling pathway_Homo sapiens_hsa046681.01976423
37Pertussis_Homo sapiens_hsa051331.01683271
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.01146084
39Insulin resistance_Homo sapiens_hsa049310.97817003
40Cardiac muscle contraction_Homo sapiens_hsa042600.96579511
41Maturity onset diabetes of the young_Homo sapiens_hsa049500.94571807
42Insulin signaling pathway_Homo sapiens_hsa049100.94384302
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.94031885
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93713871
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93636193
46Primary immunodeficiency_Homo sapiens_hsa053400.90861499
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90428624
48Toxoplasmosis_Homo sapiens_hsa051450.89787555
49Gastric acid secretion_Homo sapiens_hsa049710.89505233
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89068080
51Phagosome_Homo sapiens_hsa041450.87370313
52Circadian entrainment_Homo sapiens_hsa047130.86650787
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85972273
54Glucagon signaling pathway_Homo sapiens_hsa049220.84924383
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84274830
56VEGF signaling pathway_Homo sapiens_hsa043700.83097806
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83076342
58Malaria_Homo sapiens_hsa051440.82742853
59Dorso-ventral axis formation_Homo sapiens_hsa043200.81893593
60Regulation of autophagy_Homo sapiens_hsa041400.81201957
61Fructose and mannose metabolism_Homo sapiens_hsa000510.79649114
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78975130
63T cell receptor signaling pathway_Homo sapiens_hsa046600.76743459
64Notch signaling pathway_Homo sapiens_hsa043300.76685806
65Salivary secretion_Homo sapiens_hsa049700.75277328
66Collecting duct acid secretion_Homo sapiens_hsa049660.75252382
67Chemokine signaling pathway_Homo sapiens_hsa040620.74776214
68Platelet activation_Homo sapiens_hsa046110.73832097
69MAPK signaling pathway_Homo sapiens_hsa040100.72461950
70Long-term depression_Homo sapiens_hsa047300.70599141
71Acute myeloid leukemia_Homo sapiens_hsa052210.70389186
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69790828
73Synaptic vesicle cycle_Homo sapiens_hsa047210.69770258
74Hematopoietic cell lineage_Homo sapiens_hsa046400.68605208
75Salmonella infection_Homo sapiens_hsa051320.68564670
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67625369
77Ovarian steroidogenesis_Homo sapiens_hsa049130.66814900
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65769306
79Cholinergic synapse_Homo sapiens_hsa047250.65506033
80AMPK signaling pathway_Homo sapiens_hsa041520.64429229
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.62820210
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.62274798
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62003490
84Prolactin signaling pathway_Homo sapiens_hsa049170.60838342
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60553322
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.60538216
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.60048200
88cAMP signaling pathway_Homo sapiens_hsa040240.57762485
89Legionellosis_Homo sapiens_hsa051340.57100305
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56887273
91Influenza A_Homo sapiens_hsa051640.56717165
92Antigen processing and presentation_Homo sapiens_hsa046120.54801271
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54051794
94ABC transporters_Homo sapiens_hsa020100.51796010
95mTOR signaling pathway_Homo sapiens_hsa041500.50118764
96Morphine addiction_Homo sapiens_hsa050320.50007866
97Cocaine addiction_Homo sapiens_hsa050300.49477605
98PPAR signaling pathway_Homo sapiens_hsa033200.48718455
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48666238
100Long-term potentiation_Homo sapiens_hsa047200.48652344

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