RASA4CP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.17658863
2negative regulation of cell killing (GO:0031342)4.99058508
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.99058508
4positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.38740617
5regulation of B cell receptor signaling pathway (GO:0050855)4.37996150
6negative thymic T cell selection (GO:0045060)4.36594142
7negative T cell selection (GO:0043383)4.28244289
8interferon-gamma production (GO:0032609)4.27299864
9regulation of gamma-delta T cell differentiation (GO:0045586)4.22790032
10regulation of gamma-delta T cell activation (GO:0046643)4.11535394
11positive thymic T cell selection (GO:0045059)4.08571034
12activated T cell proliferation (GO:0050798)4.07639880
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.02764544
14tolerance induction (GO:0002507)4.02144938
15antigen processing and presentation of endogenous antigen (GO:0019883)3.94323780
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88921955
17positive T cell selection (GO:0043368)3.85322913
18leukocyte aggregation (GO:0070486)3.68828560
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.67401161
20T cell selection (GO:0045058)3.65499837
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.64286313
22negative regulation of T cell mediated immunity (GO:0002710)3.59024649
23thymic T cell selection (GO:0045061)3.57899538
24positive regulation of B cell differentiation (GO:0045579)3.56519382
25response to interleukin-15 (GO:0070672)3.53710164
26positive regulation of granulocyte differentiation (GO:0030854)3.47772235
27negative regulation of lymphocyte mediated immunity (GO:0002707)3.47621632
28cellular response to interleukin-15 (GO:0071350)3.35669385
29regulation of alpha-beta T cell proliferation (GO:0046640)3.34168146
30negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.26481110
31B cell receptor signaling pathway (GO:0050853)3.23759006
32regulation of B cell differentiation (GO:0045577)3.14391869
33mucosal-associated lymphoid tissue development (GO:0048537)3.12275020
34Peyers patch development (GO:0048541)3.12275020
35regulation of T cell mediated cytotoxicity (GO:0001914)3.00798947
36negative regulation of leukocyte mediated immunity (GO:0002704)2.99839689
37T cell migration (GO:0072678)2.93601530
38positive regulation of alpha-beta T cell proliferation (GO:0046641)2.87862957
39positive regulation of T cell mediated cytotoxicity (GO:0001916)2.87745572
40negative regulation of erythrocyte differentiation (GO:0045647)2.86828627
41germinal center formation (GO:0002467)2.85495153
42regulation of T cell tolerance induction (GO:0002664)2.81154216
43defense response to protozoan (GO:0042832)2.76172866
44mast cell activation (GO:0045576)2.71888104
45antigen receptor-mediated signaling pathway (GO:0050851)2.70835148
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.68356592
47positive regulation by organism of defense response of other organism involved in symbiotic interact2.68356592
48modulation by symbiont of host immune response (GO:0052553)2.68356592
49positive regulation by symbiont of host defense response (GO:0052509)2.68356592
50modulation by symbiont of host defense response (GO:0052031)2.68356592
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.68356592
52negative regulation of alpha-beta T cell activation (GO:0046636)2.66528488
53cellular extravasation (GO:0045123)2.65591896
54regulation of interleukin-2 biosynthetic process (GO:0045076)2.63916209
55negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.62548937
56regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.62024802
57regulation of natural killer cell mediated immunity (GO:0002715)2.62024802
58regulation of regulatory T cell differentiation (GO:0045589)2.61993340
59regulation of granulocyte differentiation (GO:0030852)2.61515489
60response to protozoan (GO:0001562)2.60762504
61detection of bacterium (GO:0016045)2.60221355
62T cell homeostasis (GO:0043029)2.60201702
63L-fucose catabolic process (GO:0042355)2.60032620
64fucose catabolic process (GO:0019317)2.60032620
65L-fucose metabolic process (GO:0042354)2.60032620
66cytidine metabolic process (GO:0046087)2.58512475
67cytidine catabolic process (GO:0006216)2.58512475
68cytidine deamination (GO:0009972)2.58512475
69regulation of alpha-beta T cell activation (GO:0046634)2.57968667
70regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.57552211
71regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.55788092
72regulation of tolerance induction (GO:0002643)2.55525430
73regulation of leukocyte mediated cytotoxicity (GO:0001910)2.55253794
74immunoglobulin mediated immune response (GO:0016064)2.53916533
75sulfation (GO:0051923)2.52773807
76pyrimidine ribonucleoside catabolic process (GO:0046133)2.52759025
77negative regulation of T-helper cell differentiation (GO:0045623)2.52503002
78negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.52503002
79negative regulation of interleukin-12 production (GO:0032695)2.51041880
80negative regulation of adaptive immune response (GO:0002820)2.50521944
81negative regulation of interleukin-6 production (GO:0032715)2.50488236
82positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.50395646
83protein K11-linked deubiquitination (GO:0035871)2.49931348
84regulation of T cell cytokine production (GO:0002724)2.49654219
85regulation of isotype switching to IgG isotypes (GO:0048302)2.49530248
86alpha-beta T cell differentiation (GO:0046632)2.46251690
87positive regulation of calcium-mediated signaling (GO:0050850)2.45731377
88negative regulation of innate immune response (GO:0045824)2.45228844
89regulation of T cell mediated immunity (GO:0002709)2.45198845
90positive regulation of T cell differentiation in thymus (GO:0033089)2.43175848
91leukocyte degranulation (GO:0043299)2.43163117
92detection of other organism (GO:0098543)2.43098284
93negative regulation of protein oligomerization (GO:0032460)2.42405259
94purinergic nucleotide receptor signaling pathway (GO:0035590)2.42266203
95mast cell degranulation (GO:0043303)2.42128824
96mast cell activation involved in immune response (GO:0002279)2.42128824
97regulation of mast cell activation (GO:0033003)2.41739936
98alpha-beta T cell activation (GO:0046631)2.41652549
99neutrophil activation involved in immune response (GO:0002283)2.40765960
100positive regulation of mast cell activation (GO:0033005)2.39668129

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.94793147
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.83325720
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.12321105
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.06664000
5RUNX_20019798_ChIP-Seq_JUKART_Human2.75078480
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.52232327
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.37016113
8EZH2_22144423_ChIP-Seq_EOC_Human2.33389133
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.15292579
10DROSHA_22980978_ChIP-Seq_HELA_Human2.09336849
11LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.09315089
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08357007
13E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.07721408
14MYB_26560356_Chip-Seq_TH2_Human1.96793555
15ZNF274_21170338_ChIP-Seq_K562_Hela1.95694389
16IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92916914
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.91188182
18SCL_19346495_ChIP-Seq_HPC-7_Human1.82892413
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.81784162
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73265309
21UTX_26944678_Chip-Seq_JUKART_Human1.70571875
22VDR_21846776_ChIP-Seq_THP-1_Human1.69480053
23GATA3_27048872_Chip-Seq_THYMUS_Human1.64841491
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57485388
25MAF_26560356_Chip-Seq_TH1_Human1.57128992
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.54170191
27MYB_26560356_Chip-Seq_TH1_Human1.49960706
28MAF_26560356_Chip-Seq_TH2_Human1.49315523
29BCL6_27268052_Chip-Seq_Bcells_Human1.47543372
30LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46578291
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.43993226
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43285908
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42384516
34VDR_24763502_ChIP-Seq_THP-1_Human1.40066030
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39418152
36REST_21632747_ChIP-Seq_MESCs_Mouse1.38789363
37SPI1_23127762_ChIP-Seq_K562_Human1.37691100
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36312922
39GATA3_26560356_Chip-Seq_TH2_Human1.36147832
40GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35519546
41GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29830425
42MYC_22102868_ChIP-Seq_BL_Human1.27533124
43SPI1_23547873_ChIP-Seq_NB4_Human1.27078493
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25709280
45EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24694241
46VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.23258833
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.22431838
48BCOR_27268052_Chip-Seq_Bcells_Human1.22336080
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18221941
50KDM2B_26808549_Chip-Seq_DND41_Human1.17948216
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16942371
52SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16841135
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16068835
54VDR_24787735_ChIP-Seq_THP-1_Human1.16012492
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15761225
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.14971147
57VDR_22108803_ChIP-Seq_LS180_Human1.11488870
58IGF1R_20145208_ChIP-Seq_DFB_Human1.11287976
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09827071
60P300_27268052_Chip-Seq_Bcells_Human1.06416582
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05827862
62PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04564729
63OCT4_19829295_ChIP-Seq_ESCs_Human1.03271503
64RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03094956
65GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02718819
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.02514861
67ERA_21632823_ChIP-Seq_H3396_Human1.02400249
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.01944943
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99122353
70NANOG_20526341_ChIP-Seq_ESCs_Human0.98205859
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96855514
72TCF7_22412390_ChIP-Seq_EML_Mouse0.96521173
73ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96437006
74P68_20966046_ChIP-Seq_HELA_Human0.96191582
75SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95914408
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95532226
77RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94820587
78E2F1_20622854_ChIP-Seq_HELA_Human0.94288650
79OCT4_20526341_ChIP-Seq_ESCs_Human0.93826624
80EZH2_27294783_Chip-Seq_ESCs_Mouse0.93736706
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93031640
82CIITA_25753668_ChIP-Seq_RAJI_Human0.92982286
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92626822
84MYC_19829295_ChIP-Seq_ESCs_Human0.92376504
85RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91762954
86STAT1_20625510_ChIP-Seq_HELA_Human0.90895224
87PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89797927
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.89418647
89RAC3_21632823_ChIP-Seq_H3396_Human0.88071938
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87537317
91FLI1_27457419_Chip-Seq_LIVER_Mouse0.86602594
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86596120
93GATA3_21878914_ChIP-Seq_MCF-7_Human0.86418080
94SMRT_27268052_Chip-Seq_Bcells_Human0.86387522
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86332435
96PHF8_20622854_ChIP-Seq_HELA_Human0.85496335
97GATA3_26560356_Chip-Seq_TH1_Human0.84969330
98JARID2_20064375_ChIP-Seq_MESCs_Mouse0.84777925
99TAF2_19829295_ChIP-Seq_ESCs_Human0.84749613
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84679131

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.29496055
2MP0003763_abnormal_thymus_physiology2.83104664
3MP0005671_abnormal_response_to2.74771895
4MP0001800_abnormal_humoral_immune2.54794066
5MP0001835_abnormal_antigen_presentation2.43181879
6MP0003436_decreased_susceptibility_to2.39358445
7MP0001790_abnormal_immune_system2.39093219
8MP0005387_immune_system_phenotype2.39093219
9MP0000685_abnormal_immune_system2.30006284
10MP0005000_abnormal_immune_tolerance2.17256956
11MP0002723_abnormal_immune_serum2.12576292
12MP0003183_abnormal_peptide_metabolism2.08714206
13MP0002420_abnormal_adaptive_immunity2.08544756
14MP0001819_abnormal_immune_cell2.05658179
15MP0005025_abnormal_response_to2.02594226
16MP0002138_abnormal_hepatobiliary_system2.01158695
17MP0005310_abnormal_salivary_gland1.95563806
18MP0002452_abnormal_antigen_presenting1.93842266
19MP0003787_abnormal_imprinting1.91329512
20MP0001501_abnormal_sleep_pattern1.87436543
21MP0001986_abnormal_taste_sensitivity1.83216086
22MP0003303_peritoneal_inflammation1.83145512
23MP0000465_gastrointestinal_hemorrhage1.77427051
24MP0002419_abnormal_innate_immunity1.73873249
25MP0009785_altered_susceptibility_to1.73658938
26MP0002148_abnormal_hypersensitivity_rea1.72491568
27MP0002277_abnormal_respiratory_mucosa1.71570825
28MP0009278_abnormal_bone_marrow1.69667104
29MP0009333_abnormal_splenocyte_physiolog1.68527486
30MP0003866_abnormal_defecation1.66818148
31MP0000716_abnormal_immune_system1.66087171
32MP0002398_abnormal_bone_marrow1.65854974
33MP0001873_stomach_inflammation1.61079085
34MP0002396_abnormal_hematopoietic_system1.57732394
35MP0006082_CNS_inflammation1.51023141
36MP0010155_abnormal_intestine_physiology1.48393110
37MP0000689_abnormal_spleen_morphology1.47542524
38MP0002653_abnormal_ependyma_morphology1.47262921
39MP0000703_abnormal_thymus_morphology1.42464524
40MP0002405_respiratory_system_inflammati1.40888397
41MP0005464_abnormal_platelet_physiology1.37603663
42MP0002722_abnormal_immune_system1.35708722
43MP0008877_abnormal_DNA_methylation1.34457884
44MP0003646_muscle_fatigue1.29280367
45MP0004142_abnormal_muscle_tone1.28737333
46MP0005075_abnormal_melanosome_morpholog1.28615911
47MP0004381_abnormal_hair_follicle1.28087078
48MP0003172_abnormal_lysosome_physiology1.26888381
49MP0001845_abnormal_inflammatory_respons1.26359910
50MP0002928_abnormal_bile_duct1.23550071
51MP0009764_decreased_sensitivity_to1.23367207
52MP0002429_abnormal_blood_cell1.22196308
53MP0001968_abnormal_touch/_nociception1.17621701
54MP0004043_abnormal_pH_regulation1.17575204
55MP0008995_early_reproductive_senescence1.17268880
56MP0005535_abnormal_body_temperature1.16596173
57MP0002822_catalepsy1.14798127
58MP0005646_abnormal_pituitary_gland1.10268931
59MP0001905_abnormal_dopamine_level1.10252199
60MP0002064_seizures1.07881730
61MP0009745_abnormal_behavioral_response1.05372127
62MP0008469_abnormal_protein_level1.04496620
63MP0001663_abnormal_digestive_system1.04185655
64MP0001533_abnormal_skeleton_physiology1.02301524
65MP0002693_abnormal_pancreas_physiology1.00829289
66MP0002876_abnormal_thyroid_physiology0.99859884
67MP0005397_hematopoietic_system_phenotyp0.99818943
68MP0001545_abnormal_hematopoietic_system0.99818943
69MP0003880_abnormal_central_pattern0.95803954
70MP0006276_abnormal_autonomic_nervous0.95048063
71MP0002735_abnormal_chemical_nociception0.92236549
72MP0008961_abnormal_basal_metabolism0.91027857
73MP0005645_abnormal_hypothalamus_physiol0.89515923
74MP0004130_abnormal_muscle_cell0.88980156
75MP0001764_abnormal_homeostasis0.88562334
76MP0002272_abnormal_nervous_system0.88194507
77MP0002572_abnormal_emotion/affect_behav0.87090473
78MP0001970_abnormal_pain_threshold0.86053670
79MP0008872_abnormal_physiological_respon0.85352567
80MP0002006_tumorigenesis0.83892060
81MP0009046_muscle_twitch0.83680902
82MP0005084_abnormal_gallbladder_morpholo0.82949998
83MP0001486_abnormal_startle_reflex0.81179981
84MP0002733_abnormal_thermal_nociception0.80386836
85MP0003879_abnormal_hair_cell0.79949619
86MP0003635_abnormal_synaptic_transmissio0.78533805
87MP0005551_abnormal_eye_electrophysiolog0.75845722
88MP0001765_abnormal_ion_homeostasis0.75774610
89MP0003878_abnormal_ear_physiology0.75344082
90MP0005377_hearing/vestibular/ear_phenot0.75344082
91MP0004947_skin_inflammation0.75166620
92MP0001919_abnormal_reproductive_system0.75088299
93MP0005448_abnormal_energy_balance0.74140442
94MP0002638_abnormal_pupillary_reflex0.72573258
95MP0002063_abnormal_learning/memory/cond0.72367582
96MP0005174_abnormal_tail_pigmentation0.72278225
97MP0003195_calcinosis0.70640971
98MP0000015_abnormal_ear_pigmentation0.70247143
99MP0001485_abnormal_pinna_reflex0.68228231
100MP0002166_altered_tumor_susceptibility0.66272923

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.98746164
2Myositis (HP:0100614)4.52669125
3Elevated erythrocyte sedimentation rate (HP:0003565)4.37126400
4Panhypogammaglobulinemia (HP:0003139)4.26113894
5Retrobulbar optic neuritis (HP:0100654)4.24511174
6Optic neuritis (HP:0100653)4.24511174
7Orchitis (HP:0100796)4.08117405
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.00254906
9Recurrent fungal infections (HP:0002841)3.80126389
10Eczematoid dermatitis (HP:0000976)3.69777207
11Recurrent cutaneous fungal infections (HP:0011370)3.42441647
12Chronic mucocutaneous candidiasis (HP:0002728)3.42441647
13Encephalitis (HP:0002383)3.36730833
14Severe combined immunodeficiency (HP:0004430)3.10800775
15Meningitis (HP:0001287)3.04132739
16Keratoconjunctivitis (HP:0001096)3.02225245
17Pustule (HP:0200039)2.93668432
18Absent rod-and cone-mediated responses on ERG (HP:0007688)2.91163772
19Keratoconjunctivitis sicca (HP:0001097)2.78837540
20Congenital stationary night blindness (HP:0007642)2.77084081
21Vasculitis (HP:0002633)2.71746618
22Abnormal rod and cone electroretinograms (HP:0008323)2.69776430
23Stomach cancer (HP:0012126)2.67798042
24Abnormality of T cells (HP:0002843)2.66749147
25Mediastinal lymphadenopathy (HP:0100721)2.66208990
26Attenuation of retinal blood vessels (HP:0007843)2.61297735
27Abnormality of T cell physiology (HP:0011840)2.57717268
28Hemoptysis (HP:0002105)2.57308901
29Abnormality of B cell number (HP:0010975)2.56948782
30Granulocytopenia (HP:0001913)2.51105000
31Episodic fever (HP:0001954)2.50417380
32Recurrent abscess formation (HP:0002722)2.49088964
33Recurrent bacterial skin infections (HP:0005406)2.47135831
34Papilledema (HP:0001085)2.45363267
35Recurrent skin infections (HP:0001581)2.43433185
36Clumsiness (HP:0002312)2.42790410
37Agammaglobulinemia (HP:0004432)2.42130350
38Leukocytosis (HP:0001974)2.41088466
39Abnormality of eosinophils (HP:0001879)2.37629230
40Pulmonary infiltrates (HP:0002113)2.37549657
41Decreased circulating renin level (HP:0003351)2.36489216
42Increased IgM level (HP:0003496)2.32068453
43Obstructive lung disease (HP:0006536)2.31370535
44Chronic obstructive pulmonary disease (HP:0006510)2.31370535
45Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.29770318
46Eosinophilia (HP:0001880)2.25738316
47Recurrent viral infections (HP:0004429)2.25042879
48IgG deficiency (HP:0004315)2.24532530
49Increased IgE level (HP:0003212)2.23374229
50Abnormality of macrophages (HP:0004311)2.22453222
51T lymphocytopenia (HP:0005403)2.22125685
52Abnormality of T cell number (HP:0011839)2.20991151
53Decreased central vision (HP:0007663)2.19723411
54Hypochromic microcytic anemia (HP:0004840)2.17933858
55Prolonged bleeding time (HP:0003010)2.17500220
56Pulmonary embolism (HP:0002204)2.15279867
57B lymphocytopenia (HP:0010976)2.13872885
58Combined immunodeficiency (HP:0005387)2.09500340
59Inflammation of the large intestine (HP:0002037)2.07127764
60Large for gestational age (HP:0001520)2.05546803
61Recurrent gram-negative bacterial infections (HP:0005420)2.02688435
62Gastrointestinal inflammation (HP:0004386)2.02652740
63Lymphopenia (HP:0001888)2.01330838
64Abnormality of the pleura (HP:0002103)2.01145854
65Hypochromic anemia (HP:0001931)1.99585727
66Spontaneous hematomas (HP:0007420)1.99163185
67Chest pain (HP:0100749)1.98885550
68Chronic sinusitis (HP:0011109)1.97492223
69Recurrent bronchitis (HP:0002837)1.96649115
70Thyroiditis (HP:0100646)1.95002689
71Hyperventilation (HP:0002883)1.94497779
72Gastrointestinal infarctions (HP:0005244)1.93745046
73Increased neuronal autofluorescent lipopigment (HP:0002074)1.93312880
74Ketosis (HP:0001946)1.92286439
75Autoimmune hemolytic anemia (HP:0001890)1.91584435
76IgM deficiency (HP:0002850)1.91381991
77Alveolar cell carcinoma (HP:0006519)1.90249032
78Focal motor seizures (HP:0011153)1.89312053
79Vertigo (HP:0002321)1.88774430
80Autoimmune thrombocytopenia (HP:0001973)1.88099487
81Abolished electroretinogram (ERG) (HP:0000550)1.87699726
82Progressive cerebellar ataxia (HP:0002073)1.86677001
83Anorexia (HP:0002039)1.85307572
84Pigmentary retinal degeneration (HP:0001146)1.84400933
85Arterial thrombosis (HP:0004420)1.82908580
86Keratitis (HP:0000491)1.82398536
87Chronic diarrhea (HP:0002028)1.82110702
88Recurrent sinusitis (HP:0011108)1.82082209
89Neurodegeneration (HP:0002180)1.81395811
90Chronic hepatic failure (HP:0100626)1.81128895
91Diplopia (HP:0000651)1.80136780
92Abnormality of binocular vision (HP:0011514)1.80136780
93Microcytic anemia (HP:0001935)1.79859755
94Papilloma (HP:0012740)1.79730340
95Verrucae (HP:0200043)1.79730340
96Congenital sensorineural hearing impairment (HP:0008527)1.75983735
97Abnormal drinking behavior (HP:0030082)1.74147581
98Polydipsia (HP:0001959)1.74147581
99Visual hallucinations (HP:0002367)1.72504523
100Abnormality of cells of the lymphoid lineage (HP:0012140)1.72411975

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.57747835
2FRK3.21027975
3TAOK33.09670546
4TXK2.81057231
5TNK22.48882366
6RIPK42.48721504
7FES2.43006511
8GRK62.07143045
9PINK12.01262264
10BTK1.91632386
11ITK1.85979501
12SYK1.80911937
13IRAK41.79915168
14SIK21.70907111
15MAP4K21.65775002
16CAMKK21.57380043
17WNK31.51064113
18CDK191.50720084
19IKBKE1.44769617
20BLK1.42713466
21TYK21.42333509
22ZAP701.41563924
23KIT1.39735724
24MAP2K31.39377527
25LCK1.33943855
26PASK1.33911270
27IKBKB1.33348660
28CAMKK11.32044514
29JAK31.31688080
30TEC1.31677535
31LYN1.22703519
32INSRR1.22416661
33HCK1.22341960
34MAP3K111.20141521
35MAPK131.19028107
36ADRBK21.13932645
37CSF1R1.12654660
38TBK11.10543235
39CSK1.10337986
40TAOK11.08524316
41NLK1.06463119
42IRAK21.06160467
43PRKCQ1.05838830
44DAPK21.03684059
45ERN11.03180771
46MAP2K61.02706020
47DYRK1B1.01775248
48MAPK121.00364989
49SIK30.96648127
50PRKD20.95553226
51MARK30.92180983
52IRAK10.91584451
53BCKDK0.91339242
54TLK10.90207493
55MARK20.88990562
56PRPF4B0.86178565
57ZAK0.84344196
58MAP3K10.80321685
59JAK20.78890080
60ACVR1B0.78089919
61PRKCH0.77123176
62OXSR10.76790185
63PDK10.75523551
64PIK3CA0.74599125
65MATK0.74328187
66MAP3K70.72401325
67FGFR30.71923529
68STK110.70834024
69MAP3K140.68827892
70JAK10.66578525
71HIPK20.65791872
72EPHA30.65072693
73MAP2K20.63822640
74NTRK20.62617875
75TESK20.62449749
76RPS6KA60.62279372
77MAPK70.61903054
78PTK2B0.61393017
79PIM10.60282021
80CHUK0.59489047
81UHMK10.57814966
82EPHB10.56315318
83NTRK30.54927822
84MAP2K40.53268039
85ADRBK10.49819364
86FGFR20.49767590
87MAP2K70.49472054
88PRKCZ0.47542289
89CAMK10.47085297
90MAP3K40.45836720
91MAPK150.44668591
92PHKG20.44210452
93PHKG10.44210452
94GRK70.44136043
95CAMK40.44080073
96RPS6KC10.42962220
97RPS6KL10.42962220
98OBSCN0.41313695
99FYN0.40605222
100GRK10.40443242

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.81516297
2Allograft rejection_Homo sapiens_hsa053302.70489451
3Graft-versus-host disease_Homo sapiens_hsa053322.63318645
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.62904452
5Autoimmune thyroid disease_Homo sapiens_hsa053202.48498439
6Type I diabetes mellitus_Homo sapiens_hsa049402.47273324
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.23970276
8Asthma_Homo sapiens_hsa053102.07112366
9T cell receptor signaling pathway_Homo sapiens_hsa046602.03601755
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.78595116
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78131752
12Leishmaniasis_Homo sapiens_hsa051401.76580546
13B cell receptor signaling pathway_Homo sapiens_hsa046621.70178564
14Osteoclast differentiation_Homo sapiens_hsa043801.67611605
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64740688
16Hematopoietic cell lineage_Homo sapiens_hsa046401.58110636
17Staphylococcus aureus infection_Homo sapiens_hsa051501.56029273
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.55285482
19Antigen processing and presentation_Homo sapiens_hsa046121.49365263
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48559435
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44286816
22Linoleic acid metabolism_Homo sapiens_hsa005911.44166300
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.32049838
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30925511
25Tuberculosis_Homo sapiens_hsa051521.29356530
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25586724
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.25093119
28Morphine addiction_Homo sapiens_hsa050321.24094126
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23000197
30Phototransduction_Homo sapiens_hsa047441.22964769
31Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20888524
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.20049121
33Measles_Homo sapiens_hsa051621.18400003
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16914666
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.10837565
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09601041
37Chemokine signaling pathway_Homo sapiens_hsa040621.04975433
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04775529
39Ether lipid metabolism_Homo sapiens_hsa005651.01910231
40Other glycan degradation_Homo sapiens_hsa005111.00924512
41Rheumatoid arthritis_Homo sapiens_hsa053230.98639328
42ABC transporters_Homo sapiens_hsa020100.96646521
43Acute myeloid leukemia_Homo sapiens_hsa052210.94640990
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93487037
45Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93340319
46Calcium signaling pathway_Homo sapiens_hsa040200.89194433
47Circadian entrainment_Homo sapiens_hsa047130.88581395
48Viral myocarditis_Homo sapiens_hsa054160.88455152
49Regulation of autophagy_Homo sapiens_hsa041400.87547260
50Nicotine addiction_Homo sapiens_hsa050330.86733536
51Platelet activation_Homo sapiens_hsa046110.86356670
52Dorso-ventral axis formation_Homo sapiens_hsa043200.85506686
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85091501
54Olfactory transduction_Homo sapiens_hsa047400.84066301
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.81802988
56Herpes simplex infection_Homo sapiens_hsa051680.81580080
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81348126
58Arachidonic acid metabolism_Homo sapiens_hsa005900.79408658
59Renin secretion_Homo sapiens_hsa049240.78748126
60Taste transduction_Homo sapiens_hsa047420.78608288
61Salivary secretion_Homo sapiens_hsa049700.78024062
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77243557
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76780706
64Cholinergic synapse_Homo sapiens_hsa047250.74901583
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73570157
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72725952
67Ovarian steroidogenesis_Homo sapiens_hsa049130.72181225
68TNF signaling pathway_Homo sapiens_hsa046680.71912203
69Butanoate metabolism_Homo sapiens_hsa006500.68907521
70Toxoplasmosis_Homo sapiens_hsa051450.68789397
71Oxytocin signaling pathway_Homo sapiens_hsa049210.67776568
72Amphetamine addiction_Homo sapiens_hsa050310.67323683
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67204309
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66623424
75Insulin secretion_Homo sapiens_hsa049110.66493779
76Serotonergic synapse_Homo sapiens_hsa047260.66159254
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65976220
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65648566
79Collecting duct acid secretion_Homo sapiens_hsa049660.64720525
80Type II diabetes mellitus_Homo sapiens_hsa049300.58146532
81Influenza A_Homo sapiens_hsa051640.58027269
82VEGF signaling pathway_Homo sapiens_hsa043700.56278235
83GABAergic synapse_Homo sapiens_hsa047270.56081035
84African trypanosomiasis_Homo sapiens_hsa051430.55902981
85MAPK signaling pathway_Homo sapiens_hsa040100.54626784
86Cocaine addiction_Homo sapiens_hsa050300.54523946
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53816620
88Malaria_Homo sapiens_hsa051440.52856213
89Glutamatergic synapse_Homo sapiens_hsa047240.51704171
90cAMP signaling pathway_Homo sapiens_hsa040240.50561390
91Choline metabolism in cancer_Homo sapiens_hsa052310.46903241
92Gastric acid secretion_Homo sapiens_hsa049710.46856913
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.46465679
94Notch signaling pathway_Homo sapiens_hsa043300.45748711
95Glycerolipid metabolism_Homo sapiens_hsa005610.45600366
96Dopaminergic synapse_Homo sapiens_hsa047280.45218769
97Inositol phosphate metabolism_Homo sapiens_hsa005620.44426539
98Prolactin signaling pathway_Homo sapiens_hsa049170.43174035
99Vitamin digestion and absorption_Homo sapiens_hsa049770.42728068
100Epstein-Barr virus infection_Homo sapiens_hsa051690.42456882

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