RASA4DP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.74850670
2positive regulation of T cell cytokine production (GO:0002726)3.69298294
3positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.41693463
4regulation of B cell receptor signaling pathway (GO:0050855)3.35417998
5sarcoplasmic reticulum calcium ion transport (GO:0070296)3.34766122
6tachykinin receptor signaling pathway (GO:0007217)3.29285785
7positive regulation of gamma-delta T cell activation (GO:0046645)3.20347302
8metallo-sulfur cluster assembly (GO:0031163)3.17681641
9iron-sulfur cluster assembly (GO:0016226)3.17681641
10positive regulation of B cell differentiation (GO:0045579)3.16000220
11nucleoside diphosphate biosynthetic process (GO:0009133)3.15490329
12positive regulation of interleukin-2 production (GO:0032743)3.10418745
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.09993593
14regulation of skeletal muscle contraction (GO:0014819)3.04603240
15ADP metabolic process (GO:0046031)2.99478979
16mature B cell differentiation (GO:0002335)2.98519799
17cytidine deamination (GO:0009972)2.96674028
18cytidine metabolic process (GO:0046087)2.96674028
19cytidine catabolic process (GO:0006216)2.96674028
20deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.94225587
21purinergic nucleotide receptor signaling pathway (GO:0035590)2.90341732
22actin-myosin filament sliding (GO:0033275)2.89623846
23muscle filament sliding (GO:0030049)2.89623846
24cellular response to exogenous dsRNA (GO:0071360)2.89602952
25response to host immune response (GO:0052572)2.86140576
26response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.86140576
27dendritic cell chemotaxis (GO:0002407)2.82699987
28regulation of alpha-beta T cell proliferation (GO:0046640)2.81799978
29negative regulation of cell killing (GO:0031342)2.81701707
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81701707
31piRNA metabolic process (GO:0034587)2.81199755
32tryptophan catabolic process (GO:0006569)2.80648417
33indole-containing compound catabolic process (GO:0042436)2.80648417
34indolalkylamine catabolic process (GO:0046218)2.80648417
35skeletal muscle contraction (GO:0003009)2.78550597
36regulation of relaxation of muscle (GO:1901077)2.78154837
37T cell migration (GO:0072678)2.78082166
38protein ADP-ribosylation (GO:0006471)2.77175464
39cellular response to zinc ion (GO:0071294)2.74999961
40antigen processing and presentation of endogenous antigen (GO:0019883)2.74669607
41mature B cell differentiation involved in immune response (GO:0002313)2.74095703
42pyrimidine ribonucleoside catabolic process (GO:0046133)2.72275569
43regulation of T cell cytokine production (GO:0002724)2.66497149
44purine nucleotide salvage (GO:0032261)2.64956722
45cellular response to interferon-beta (GO:0035458)2.64354665
46regulation of T-helper 1 cell differentiation (GO:0045625)2.61587553
47positive regulation of uterine smooth muscle contraction (GO:0070474)2.61333700
48negative regulation of type 2 immune response (GO:0002829)2.60719306
49response to interferon-beta (GO:0035456)2.58011824
50regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.58007279
51regulation of lymphocyte chemotaxis (GO:1901623)2.57414698
52Peyers patch development (GO:0048541)2.57341003
53mucosal-associated lymphoid tissue development (GO:0048537)2.57341003
54negative regulation of telomere maintenance (GO:0032205)2.55897465
55drinking behavior (GO:0042756)2.55580957
56positive regulation of T cell differentiation in thymus (GO:0033089)2.54890540
57positive regulation of alpha-beta T cell proliferation (GO:0046641)2.53684650
58DNA methylation involved in gamete generation (GO:0043046)2.52917388
59positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.52739754
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.52465223
61regulation of B cell differentiation (GO:0045577)2.50024905
62aggressive behavior (GO:0002118)2.49710442
63positive regulation of T cell differentiation (GO:0045582)2.49507433
64immunoglobulin mediated immune response (GO:0016064)2.48799017
65negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.48794191
66regulation of autophagic vacuole assembly (GO:2000785)2.47778423
67interferon-gamma production (GO:0032609)2.46364684
68negative regulation of interleukin-17 production (GO:0032700)2.46227427
69G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.45283042
70regulation of T cell receptor signaling pathway (GO:0050856)2.43754473
71positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.43740450
72regulation of T cell tolerance induction (GO:0002664)2.43568609
73neutrophil activation involved in immune response (GO:0002283)2.43022243
74negative regulation of interleukin-12 production (GO:0032695)2.41822243
75cellular response to nicotine (GO:0071316)2.41146098
76phosphatidylglycerol biosynthetic process (GO:0006655)2.40512767
77response to type I interferon (GO:0034340)2.40109338
78type I interferon signaling pathway (GO:0060337)2.39984188
79cellular response to type I interferon (GO:0071357)2.39984188
80positive regulation of digestive system process (GO:0060456)2.39174721
81response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.38821391
82response to host (GO:0075136)2.38821391
83response to host defenses (GO:0052200)2.38821391
84Arp2/3 complex-mediated actin nucleation (GO:0034314)2.38703283
85positive regulation of T-helper cell differentiation (GO:0045624)2.38578551
86regulation of vacuole organization (GO:0044088)2.38404857
87positive regulation of T cell mediated immunity (GO:0002711)2.37415909
88regulation of interleukin-2 production (GO:0032663)2.37373592
89positive regulation of catecholamine secretion (GO:0033605)2.37131000
90ubiquinone biosynthetic process (GO:0006744)2.37050719
91dendritic cell migration (GO:0036336)2.35701012
92positive regulation of T-helper 1 type immune response (GO:0002827)2.35362031
93interferon-gamma-mediated signaling pathway (GO:0060333)2.34421846
94branched-chain amino acid metabolic process (GO:0009081)2.33919277
95neural tube formation (GO:0001841)2.33566724
96tryptophan metabolic process (GO:0006568)2.33340206
97regulation of alpha-beta T cell activation (GO:0046634)2.33211499
98NIK/NF-kappaB signaling (GO:0038061)2.32823671
99positive regulation of T cell mediated cytotoxicity (GO:0001916)2.32742957
100positive thymic T cell selection (GO:0045059)2.32655975

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.00325641
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.19758069
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.19890731
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.81540982
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.69207717
6IGF1R_20145208_ChIP-Seq_DFB_Human2.64604059
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.49288405
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45319689
9LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.38152258
10EZH2_22144423_ChIP-Seq_EOC_Human2.29270375
11RUNX_20019798_ChIP-Seq_JUKART_Human2.18658679
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17242595
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.05845800
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.95451892
15CIITA_25753668_ChIP-Seq_RAJI_Human1.94423102
16ZNF274_21170338_ChIP-Seq_K562_Hela1.93792046
17MYB_26560356_Chip-Seq_TH2_Human1.90113878
18ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85778787
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79058255
20LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.78844327
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.77654537
22MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76602172
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74883897
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72151036
25BCL6_27268052_Chip-Seq_Bcells_Human1.68312372
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.67444438
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65119365
28GATA3_27048872_Chip-Seq_THYMUS_Human1.63756970
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.55025604
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53602617
31SPI1_23127762_ChIP-Seq_K562_Human1.51084010
32UTX_26944678_Chip-Seq_JUKART_Human1.47394904
33MAF_26560356_Chip-Seq_TH1_Human1.43445821
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.42431437
35SPI1_23547873_ChIP-Seq_NB4_Human1.41646055
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.39056333
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38749726
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38496290
39RAC3_21632823_ChIP-Seq_H3396_Human1.34700497
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34208930
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.33043113
42BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32939307
43PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.32424889
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30117631
45GATA3_26560356_Chip-Seq_TH2_Human1.28600742
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28321569
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28236641
48MAF_26560356_Chip-Seq_TH2_Human1.27409538
49VDR_21846776_ChIP-Seq_THP-1_Human1.25827579
50STAT1_20625510_ChIP-Seq_HELA_Human1.25676821
51MYB_26560356_Chip-Seq_TH1_Human1.22961747
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21249958
53BCOR_27268052_Chip-Seq_Bcells_Human1.18816687
54OCT4_20526341_ChIP-Seq_ESCs_Human1.18688046
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18254932
56VDR_24787735_ChIP-Seq_THP-1_Human1.16101683
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15347039
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14308928
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13776206
60VDR_23849224_ChIP-Seq_CD4+_Human1.13468180
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12299432
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12027916
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11724835
64P300_27268052_Chip-Seq_Bcells_Human1.11190973
65FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09409617
66CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08504906
67GBX2_23144817_ChIP-Seq_PC3_Human1.07750807
68PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05096713
69SPI1_20517297_ChIP-Seq_HL60_Human1.04798005
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.03047437
71ERA_21632823_ChIP-Seq_H3396_Human0.98800287
72CTCF_20526341_ChIP-Seq_ESCs_Human0.98347267
73NANOG_20526341_ChIP-Seq_ESCs_Human0.98265284
74GATA1_19941827_ChIP-Seq_MEL_Mouse0.98165002
75E2F1_20622854_ChIP-Seq_HELA_Human0.97007278
76VDR_24763502_ChIP-Seq_THP-1_Human0.95070204
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93723212
78GATA2_21666600_ChIP-Seq_HMVEC_Human0.93169303
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92243653
80MYC_22102868_ChIP-Seq_BL_Human0.92167110
81SCL_19346495_ChIP-Seq_HPC-7_Human0.91260545
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91177296
83P68_20966046_ChIP-Seq_HELA_Human0.90419661
84NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90106627
85YY1_21170310_ChIP-Seq_MESCs_Mouse0.88527878
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88014459
87EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87299937
88PHF8_20622854_ChIP-Seq_HELA_Human0.86020230
89CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85898047
90TAF2_19829295_ChIP-Seq_ESCs_Human0.85583872
91CTCF_26484167_Chip-Seq_Bcells_Mouse0.85488235
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85292818
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84205240
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83366479
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83142023
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82873127
97GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82781656
98RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82771204
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82349994
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80420556

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.53810788
2MP0003646_muscle_fatigue3.04917426
3MP0001835_abnormal_antigen_presentation2.87661393
4MP0005671_abnormal_response_to2.58680227
5MP0005000_abnormal_immune_tolerance2.53343802
6MP0002837_dystrophic_cardiac_calcinosis2.43530266
7MP0002148_abnormal_hypersensitivity_rea2.30311939
8MP0001800_abnormal_humoral_immune2.21450049
9MP0000749_muscle_degeneration2.19272880
10MP0009785_altered_susceptibility_to2.09851119
11MP0002723_abnormal_immune_serum2.01731046
12MP0002452_abnormal_antigen_presenting1.89725066
13MP0006082_CNS_inflammation1.88832492
14MP0000685_abnormal_immune_system1.88759583
15MP0005645_abnormal_hypothalamus_physiol1.87170802
16MP0002332_abnormal_exercise_endurance1.86617876
17MP0009278_abnormal_bone_marrow1.86138942
18MP0005025_abnormal_response_to1.85702437
19MP0003436_decreased_susceptibility_to1.83893552
20MP0001790_abnormal_immune_system1.82722930
21MP0005387_immune_system_phenotype1.82722930
22MP0002419_abnormal_innate_immunity1.82618126
23MP0002420_abnormal_adaptive_immunity1.79413169
24MP0003806_abnormal_nucleotide_metabolis1.78791490
25MP0001819_abnormal_immune_cell1.76806729
26MP0003303_peritoneal_inflammation1.75838067
27MP0000465_gastrointestinal_hemorrhage1.74845923
28MP0003763_abnormal_thymus_physiology1.69102599
29MP0005058_abnormal_lysosome_morphology1.61403149
30MP0006036_abnormal_mitochondrial_physio1.57698630
31MP0004145_abnormal_muscle_electrophysio1.56428535
32MP0000604_amyloidosis1.56036205
33MP0001501_abnormal_sleep_pattern1.54545926
34MP0004147_increased_porphyrin_level1.53892651
35MP0002138_abnormal_hepatobiliary_system1.53156399
36MP0005167_abnormal_blood-brain_barrier1.48753525
37MP0005266_abnormal_metabolism1.45609607
38MP0003075_altered_response_to1.42703579
39MP0000751_myopathy1.42232870
40MP0000689_abnormal_spleen_morphology1.41035803
41MP0000716_abnormal_immune_system1.38007441
42MP0003300_gastrointestinal_ulcer1.36549448
43MP0004036_abnormal_muscle_relaxation1.32959160
44MP0009764_decreased_sensitivity_to1.32885517
45MP0009333_abnormal_splenocyte_physiolog1.32713459
46MP0002653_abnormal_ependyma_morphology1.32534429
47MP0002398_abnormal_bone_marrow1.30842395
48MP0000013_abnormal_adipose_tissue1.27338098
49MP0001845_abnormal_inflammatory_respons1.23321019
50MP0006276_abnormal_autonomic_nervous1.22722958
51MP0005451_abnormal_body_composition1.21923053
52MP0009840_abnormal_foam_cell1.21723633
53MP0001986_abnormal_taste_sensitivity1.21691612
54MP0001542_abnormal_bone_strength1.20801066
55MP0010386_abnormal_urinary_bladder1.19874814
56MP0000343_altered_response_to1.19330783
57MP0002722_abnormal_immune_system1.18394331
58MP0002106_abnormal_muscle_physiology1.17863990
59MP0008469_abnormal_protein_level1.15673457
60MP0001533_abnormal_skeleton_physiology1.13886856
61MP0001968_abnormal_touch/_nociception1.11328552
62MP0003329_amyloid_beta_deposits1.08823940
63MP0002822_catalepsy1.06493578
64MP0005310_abnormal_salivary_gland1.05375135
65MP0004130_abnormal_muscle_cell1.03099728
66MP0006035_abnormal_mitochondrial_morpho1.02048916
67MP0001545_abnormal_hematopoietic_system1.01612806
68MP0005397_hematopoietic_system_phenotyp1.01612806
69MP0002693_abnormal_pancreas_physiology1.00942993
70MP0000759_abnormal_skeletal_muscle0.99989955
71MP0002429_abnormal_blood_cell0.99879832
72MP0001984_abnormal_olfaction0.99172905
73MP0010155_abnormal_intestine_physiology0.97921268
74MP0000747_muscle_weakness0.97663205
75MP0004233_abnormal_muscle_weight0.96645325
76MP0008877_abnormal_DNA_methylation0.95658395
77MP0002269_muscular_atrophy0.93360013
78MP0001529_abnormal_vocalization0.92756593
79MP0005369_muscle_phenotype0.92082292
80MP0002405_respiratory_system_inflammati0.91532787
81MP0005535_abnormal_body_temperature0.90876088
82MP0002139_abnormal_hepatobiliary_system0.90494786
83MP0005166_decreased_susceptibility_to0.90476761
84MP0002127_abnormal_cardiovascular_syste0.89143263
85MP0003656_abnormal_erythrocyte_physiolo0.88883919
86MP0001905_abnormal_dopamine_level0.87385920
87MP0001764_abnormal_homeostasis0.84042854
88MP0004084_abnormal_cardiac_muscle0.82990140
89MP0003866_abnormal_defecation0.82569480
90MP0005464_abnormal_platelet_physiology0.82552946
91MP0003172_abnormal_lysosome_physiology0.82322678
92MP0004043_abnormal_pH_regulation0.82263808
93MP0005620_abnormal_muscle_contractility0.81515661
94MP0000230_abnormal_systemic_arterial0.79404452
95MP0004510_myositis0.79153061
96MP0000703_abnormal_thymus_morphology0.78848553
97MP0005376_homeostasis/metabolism_phenot0.78666787
98MP0009046_muscle_twitch0.77888886
99MP0002733_abnormal_thermal_nociception0.76949229
100MP0005330_cardiomyopathy0.76000003

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.12172586
2Muscle fiber inclusion bodies (HP:0100299)4.16409854
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.05059564
4Exercise-induced muscle cramps (HP:0003710)4.04488143
5Nemaline bodies (HP:0003798)3.56578603
6Rhabdomyolysis (HP:0003201)3.39074224
7Myoglobinuria (HP:0002913)3.23979788
8Granulocytopenia (HP:0001913)3.20391401
9Myopathic facies (HP:0002058)3.20202005
10Eosinophilia (HP:0001880)3.18278791
11Rimmed vacuoles (HP:0003805)3.14267070
12Panhypogammaglobulinemia (HP:0003139)3.11409125
13Abnormality of liposaccharide metabolism (HP:0010968)3.07236670
14Abnormality of glycosphingolipid metabolism (HP:0004343)3.07236670
15Abnormality of glycolipid metabolism (HP:0010969)3.07236670
16Centrally nucleated skeletal muscle fibers (HP:0003687)3.05109550
17EMG: myopathic abnormalities (HP:0003458)2.88335141
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.82834580
19Decreased activity of mitochondrial respiratory chain (HP:0008972)2.82834580
20Dicarboxylic aciduria (HP:0003215)2.81176101
21Abnormality of dicarboxylic acid metabolism (HP:0010995)2.81176101
22Elevated erythrocyte sedimentation rate (HP:0003565)2.77610814
23Type I transferrin isoform profile (HP:0003642)2.71183709
24Abnormality of eosinophils (HP:0001879)2.70914262
25Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.69158092
26Abnormal protein N-linked glycosylation (HP:0012347)2.69158092
27Abnormal protein glycosylation (HP:0012346)2.69158092
28Abnormal glycosylation (HP:0012345)2.69158092
29Ragged-red muscle fibers (HP:0003200)2.67048394
30Muscle hypertrophy of the lower extremities (HP:0008968)2.66493561
31Stomatitis (HP:0010280)2.65278622
32Agammaglobulinemia (HP:0004432)2.64366553
33Distal arthrogryposis (HP:0005684)2.63317643
34Ketosis (HP:0001946)2.57510886
35Muscle fiber splitting (HP:0003555)2.52938372
36Methylmalonic acidemia (HP:0002912)2.50315893
37Increased muscle lipid content (HP:0009058)2.50203861
38Recurrent viral infections (HP:0004429)2.48316750
39Type 1 muscle fiber predominance (HP:0003803)2.47327106
40IgG deficiency (HP:0004315)2.46552329
41Increased intramyocellular lipid droplets (HP:0012240)2.39545422
42Asymmetric septal hypertrophy (HP:0001670)2.38326923
43Facial diplegia (HP:0001349)2.35525665
44Abnormality of mucopolysaccharide metabolism (HP:0011020)2.34325021
45Abnormality of polysaccharide metabolism (HP:0011012)2.34325021
46Abnormality of glycosaminoglycan metabolism (HP:0004371)2.34325021
47Dysostosis multiplex (HP:0000943)2.33625815
48Neck muscle weakness (HP:0000467)2.32821158
49Methylmalonic aciduria (HP:0012120)2.32532664
50Calf muscle hypertrophy (HP:0008981)2.31357473
51Recurrent fungal infections (HP:0002841)2.31272047
52Mediastinal lymphadenopathy (HP:0100721)2.29970635
53Reduced antithrombin III activity (HP:0001976)2.28786276
54Severe combined immunodeficiency (HP:0004430)2.28226181
55Abnormality of the calf musculature (HP:0001430)2.26164928
56Leukocytosis (HP:0001974)2.24154870
57Ulnar deviation of the wrist (HP:0003049)2.23976822
58Clumsiness (HP:0002312)2.20587069
59Abnormality of skeletal muscle fiber size (HP:0012084)2.19996657
60Hyporeflexia of lower limbs (HP:0002600)2.16920395
61Urinary glycosaminoglycan excretion (HP:0003541)2.16421568
62Mucopolysacchariduria (HP:0008155)2.16421568
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.12128611
64Ketoacidosis (HP:0001993)2.11427747
65Vacuolated lymphocytes (HP:0001922)2.10505689
66Hyperglycinemia (HP:0002154)2.10498043
67Frequent falls (HP:0002359)2.08591975
68Autoimmune thrombocytopenia (HP:0001973)2.05863487
69Abnormality of fatty-acid metabolism (HP:0004359)2.02915918
70Type II lissencephaly (HP:0007260)1.95196424
71Agitation (HP:0000713)1.94190586
72Myositis (HP:0100614)1.92022428
73Recurrent cutaneous fungal infections (HP:0011370)1.91389831
74Chronic mucocutaneous candidiasis (HP:0002728)1.91389831
75Pulmonary infiltrates (HP:0002113)1.90583474
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.90021108
77Muscle stiffness (HP:0003552)1.88656325
78Abnormality of lateral ventricle (HP:0030047)1.87790314
79Increased variability in muscle fiber diameter (HP:0003557)1.87380548
80Hepatic necrosis (HP:0002605)1.87379016
81Beaking of vertebral bodies (HP:0004568)1.86741971
82Malignant hyperthermia (HP:0002047)1.86031875
83Abnormality of the columella (HP:0009929)1.85326924
84Colitis (HP:0002583)1.82635047
85Encephalitis (HP:0002383)1.82265651
86Adactyly (HP:0009776)1.81350939
87Meningitis (HP:0001287)1.80924648
88Exercise intolerance (HP:0003546)1.80478913
89Abnormal mitochondria in muscle tissue (HP:0008316)1.79998841
90Lactic acidosis (HP:0003128)1.79708547
91Abnormality of vitamin B metabolism (HP:0004340)1.79449293
92Brushfield spots (HP:0001088)1.78398434
93Type 2 muscle fiber atrophy (HP:0003554)1.76489205
94Hepatocellular necrosis (HP:0001404)1.76217509
95Amyotrophic lateral sclerosis (HP:0007354)1.76130484
96Xerostomia (HP:0000217)1.74992802
97Combined immunodeficiency (HP:0005387)1.74860003
98Mitochondrial inheritance (HP:0001427)1.74571669
99Abnormality of T cells (HP:0002843)1.74172697
100Hypertensive crisis (HP:0100735)1.71464318

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK36.10981827
2MAP4K25.12022743
3OBSCN3.48232817
4PINK13.42373652
5BCKDK3.02530168
6MAP4K12.68327667
7RIPK42.42100219
8PHKG12.19423863
9PHKG22.19423863
10SIK21.85194030
11CSNK1G31.84486345
12KIT1.69007502
13CSNK1A1L1.65709648
14TBK11.56834835
15PIM21.54568419
16MAP2K71.52359298
17TXK1.46760418
18GRK61.43530983
19CSNK1G11.41769944
20MAPKAPK31.39700207
21SYK1.39428888
22CSNK1G21.36798393
23TRIM281.30244505
24FES1.29091148
25IRAK21.25581637
26ADRBK21.24625632
27CSF1R1.22780017
28CDK191.20262438
29MAP3K11.17298526
30ARAF1.14229804
31GRK51.12962179
32IKBKB1.12049051
33MAP3K111.11823539
34MATK1.10646814
35MAP3K141.09447696
36GRK71.03871889
37IKBKE0.99940196
38KDR0.99763710
39IRAK40.95458126
40HCK0.94984224
41TTN0.93409652
42MAP3K40.92958103
43BTK0.90734135
44BMPR20.87662980
45TESK20.81885420
46MARK30.80304078
47DAPK20.77897126
48IRAK10.77661770
49ITK0.77134418
50RPS6KA50.74067065
51ZAK0.71337151
52DAPK10.71273234
53MAP2K30.71099447
54TNK20.70070818
55LYN0.70051347
56TLK10.69789603
57PRKCQ0.67707771
58TESK10.62729382
59ERN10.61626981
60MAPK130.61594507
61TAOK10.61444194
62MAPK110.60888717
63MAPK120.60566438
64JAK20.59918202
65MOS0.58408222
66JAK30.57664303
67LCK0.57560551
68CAMKK20.56115048
69MAP3K70.55706949
70MAP2K60.54019115
71BLK0.52016740
72CAMK40.49940932
73TEC0.49900666
74EPHA30.49656636
75IRAK30.49039727
76LIMK10.47228989
77PIM10.44098915
78RPS6KL10.42335343
79RPS6KC10.42335343
80CAMKK10.41817251
81RPS6KA60.41115346
82CHUK0.40675298
83MAP2K20.39874341
84MAP2K40.38384719
85TRPM70.36773907
86ZAP700.36397702
87TAOK20.36166853
88MAPK70.36127538
89PTK2B0.35305664
90MAP3K30.35221024
91PDK10.34600270
92JAK10.33899945
93NEK20.33897127
94MAPK40.33097856
95TYK20.32129810
96GRK10.31492440
97FLT30.31307318
98PIK3CA0.28945881
99EPHA40.28551702
100TGFBR20.28125534

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.57433933
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.23240410
3Allograft rejection_Homo sapiens_hsa053303.22400193
4Type I diabetes mellitus_Homo sapiens_hsa049403.09951017
5Graft-versus-host disease_Homo sapiens_hsa053322.96058986
6Autoimmune thyroid disease_Homo sapiens_hsa053202.87914476
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.58533168
8Asthma_Homo sapiens_hsa053102.51959279
9Other glycan degradation_Homo sapiens_hsa005112.36555167
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.33532171
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.17000620
12Rheumatoid arthritis_Homo sapiens_hsa053232.02818672
13Antigen processing and presentation_Homo sapiens_hsa046121.95381527
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94130793
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.92197967
16Leishmaniasis_Homo sapiens_hsa051401.91560357
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85172990
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.65115345
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.59810732
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57747539
21Sulfur relay system_Homo sapiens_hsa041221.55770815
22Tuberculosis_Homo sapiens_hsa051521.54600162
23Viral myocarditis_Homo sapiens_hsa054161.51693998
24Legionellosis_Homo sapiens_hsa051341.46880307
25Hematopoietic cell lineage_Homo sapiens_hsa046401.41020056
26Osteoclast differentiation_Homo sapiens_hsa043801.38908804
27Staphylococcus aureus infection_Homo sapiens_hsa051501.38885187
28Peroxisome_Homo sapiens_hsa041461.38072801
29Lysosome_Homo sapiens_hsa041421.36036177
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35704475
31T cell receptor signaling pathway_Homo sapiens_hsa046601.23947626
32Butanoate metabolism_Homo sapiens_hsa006501.16814513
33Herpes simplex infection_Homo sapiens_hsa051681.16157756
34Shigellosis_Homo sapiens_hsa051311.08835102
35B cell receptor signaling pathway_Homo sapiens_hsa046621.02371244
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01681677
37Salmonella infection_Homo sapiens_hsa051320.99934899
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95914145
39Jak-STAT signaling pathway_Homo sapiens_hsa046300.95043770
40Phototransduction_Homo sapiens_hsa047440.94477078
41TNF signaling pathway_Homo sapiens_hsa046680.92868041
42Measles_Homo sapiens_hsa051620.91230096
43Influenza A_Homo sapiens_hsa051640.88972630
44Malaria_Homo sapiens_hsa051440.88827656
45Regulation of autophagy_Homo sapiens_hsa041400.88562105
46Olfactory transduction_Homo sapiens_hsa047400.88085240
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85264394
48Phagosome_Homo sapiens_hsa041450.85069743
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82839690
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.79820913
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79818215
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78456333
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77969624
54Pertussis_Homo sapiens_hsa051330.77656378
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74296077
56Systemic lupus erythematosus_Homo sapiens_hsa053220.73935235
57Acute myeloid leukemia_Homo sapiens_hsa052210.73171895
58Calcium signaling pathway_Homo sapiens_hsa040200.72789034
59Toxoplasmosis_Homo sapiens_hsa051450.72682119
60Oxytocin signaling pathway_Homo sapiens_hsa049210.70809218
61Salivary secretion_Homo sapiens_hsa049700.70531563
62Chemokine signaling pathway_Homo sapiens_hsa040620.69491956
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66400002
64Collecting duct acid secretion_Homo sapiens_hsa049660.66298300
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66106775
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64822162
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64211135
68Renin secretion_Homo sapiens_hsa049240.62506453
69Epstein-Barr virus infection_Homo sapiens_hsa051690.61472573
70Circadian rhythm_Homo sapiens_hsa047100.59239179
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52125942
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51728837
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47892861
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47077789
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45814912
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44164467
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.43824851
78Purine metabolism_Homo sapiens_hsa002300.42996377
79Parkinsons disease_Homo sapiens_hsa050120.38474673
80Hepatitis C_Homo sapiens_hsa051600.36519299
81Oxidative phosphorylation_Homo sapiens_hsa001900.35314755
82Apoptosis_Homo sapiens_hsa042100.34799901
83ABC transporters_Homo sapiens_hsa020100.33688912
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32780889
85African trypanosomiasis_Homo sapiens_hsa051430.32625559
86Arachidonic acid metabolism_Homo sapiens_hsa005900.32381210
87Tryptophan metabolism_Homo sapiens_hsa003800.31191777
88Platelet activation_Homo sapiens_hsa046110.29433989
89Hepatitis B_Homo sapiens_hsa051610.28948059
90Morphine addiction_Homo sapiens_hsa050320.28582673
91Type II diabetes mellitus_Homo sapiens_hsa049300.28334922
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25527410
93RNA degradation_Homo sapiens_hsa030180.24821136
94Dilated cardiomyopathy_Homo sapiens_hsa054140.24717073
95Insulin resistance_Homo sapiens_hsa049310.23575319
96Circadian entrainment_Homo sapiens_hsa047130.23152521
97Glucagon signaling pathway_Homo sapiens_hsa049220.21636292
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21128279
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20852624
100Endocytosis_Homo sapiens_hsa041440.20202123

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