RASAL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.10244700
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.73508965
3synaptic vesicle maturation (GO:0016188)5.68504780
4locomotory exploration behavior (GO:0035641)5.55890628
5ionotropic glutamate receptor signaling pathway (GO:0035235)5.17878547
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.17708923
7synaptic vesicle exocytosis (GO:0016079)5.15901687
8vocalization behavior (GO:0071625)5.11753345
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.04537945
10glutamate secretion (GO:0014047)5.04472492
11neuronal action potential propagation (GO:0019227)4.83685994
12regulation of synaptic vesicle exocytosis (GO:2000300)4.81223195
13regulation of glutamate receptor signaling pathway (GO:1900449)4.76993089
14protein localization to synapse (GO:0035418)4.75243382
15glycosphingolipid catabolic process (GO:0046479)4.66589146
16glutamate receptor signaling pathway (GO:0007215)4.55610047
17synaptic transmission, glutamatergic (GO:0035249)4.50539899
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.48134449
19regulation of neuronal synaptic plasticity (GO:0048168)4.47332769
20neuron cell-cell adhesion (GO:0007158)4.34377910
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.31646684
22regulation of synaptic vesicle transport (GO:1902803)4.27590643
23exploration behavior (GO:0035640)4.27503576
24adenosine receptor signaling pathway (GO:0001973)4.18325767
25long-term memory (GO:0007616)4.14382888
26dendritic spine morphogenesis (GO:0060997)4.13220173
27glycolipid catabolic process (GO:0019377)4.13068758
28neuron-neuron synaptic transmission (GO:0007270)4.12933924
29regulation of excitatory postsynaptic membrane potential (GO:0060079)4.08639963
30regulation of mononuclear cell migration (GO:0071675)4.07775024
31positive regulation of membrane potential (GO:0045838)4.07322351
32positive regulation of mast cell degranulation (GO:0043306)4.04799018
33positive regulation of mast cell activation involved in immune response (GO:0033008)4.04799018
34regulation of dendritic spine morphogenesis (GO:0061001)4.02907163
35ceramide catabolic process (GO:0046514)3.95769987
36transmission of nerve impulse (GO:0019226)3.91828922
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.85016454
38gamma-aminobutyric acid signaling pathway (GO:0007214)3.83583015
39neurotransmitter secretion (GO:0007269)3.82174248
40regulation of postsynaptic membrane potential (GO:0060078)3.80445991
41regulation of synaptic plasticity (GO:0048167)3.75803003
42negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.74553371
43neuron recognition (GO:0008038)3.70441665
44oligosaccharide catabolic process (GO:0009313)3.70421665
45neuronal ion channel clustering (GO:0045161)3.70031697
46presynaptic membrane assembly (GO:0097105)3.64392682
47layer formation in cerebral cortex (GO:0021819)3.62101478
48G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.59539606
49long-term synaptic potentiation (GO:0060291)3.59193437
50positive regulation of mast cell activation (GO:0033005)3.54571253
51regulation of dendritic spine development (GO:0060998)3.54207921
52dendritic spine organization (GO:0097061)3.52299921
53N-acetylneuraminate metabolic process (GO:0006054)3.50223799
54negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.48438916
55L-amino acid import (GO:0043092)3.47426179
56positive regulation of leukocyte degranulation (GO:0043302)3.47040488
57neurotransmitter-gated ion channel clustering (GO:0072578)3.46718017
58amino sugar catabolic process (GO:0046348)3.45893619
59synaptic vesicle endocytosis (GO:0048488)3.45505106
60positive regulation of monocyte chemotaxis (GO:0090026)3.45192035
61regulation of vesicle fusion (GO:0031338)3.44695227
62negative regulation of interleukin-12 production (GO:0032695)3.42652372
63regulation of glutamate secretion (GO:0014048)3.42480331
64presynaptic membrane organization (GO:0097090)3.42471225
65regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.40821329
66membrane lipid catabolic process (GO:0046466)3.36299434
67regulation of synapse structural plasticity (GO:0051823)3.36139214
68negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35854009
69gamma-aminobutyric acid transport (GO:0015812)3.34967900
70positive regulation of dendritic spine development (GO:0060999)3.33979535
71negative regulation of amino acid transport (GO:0051956)3.32047303
72axonal fasciculation (GO:0007413)3.30500843
73positive regulation of neurotransmitter secretion (GO:0001956)3.27791222
74regulation of neurotransmitter secretion (GO:0046928)3.25909385
75proline transport (GO:0015824)3.25444164
76cellular potassium ion homeostasis (GO:0030007)3.25047336
77regulation of mast cell degranulation (GO:0043304)3.24749092
78regulation of macrophage chemotaxis (GO:0010758)3.23850731
79neurotransmitter transport (GO:0006836)3.21970372
80regulation of leukocyte degranulation (GO:0043300)3.21232896
81macrophage activation involved in immune response (GO:0002281)3.20937136
82sphingolipid catabolic process (GO:0030149)3.19590671
83cellular response to thyroid hormone stimulus (GO:0097067)3.19437701
84neuromuscular process controlling balance (GO:0050885)3.15988826
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.14454316
86ganglioside metabolic process (GO:0001573)3.14330080
87neuromuscular process controlling posture (GO:0050884)3.13884190
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12788722
89membrane depolarization (GO:0051899)3.11928182
90regulation of regulated secretory pathway (GO:1903305)3.11810032
91positive regulation of heat generation (GO:0031652)3.11588614
92activation of protein kinase A activity (GO:0034199)3.10129235
93chemosensory behavior (GO:0007635)3.09358209
94positive regulation of synaptic transmission, GABAergic (GO:0032230)3.08270053
95mating behavior (GO:0007617)3.07532493
96glycerophospholipid catabolic process (GO:0046475)3.07327431
97amino acid import (GO:0043090)3.06012763
98regulation of synaptic transmission, glutamatergic (GO:0051966)3.05306798
99neutrophil activation involved in immune response (GO:0002283)3.04307639
100learning (GO:0007612)3.04131541
101response to acidic pH (GO:0010447)3.02446114
102vesicle transport along microtubule (GO:0047496)3.00188544
103behavioral fear response (GO:0001662)2.99287169
104behavioral defense response (GO:0002209)2.99287169
105T-helper 1 type immune response (GO:0042088)2.99075440
106long term synaptic depression (GO:0060292)2.96875625
107adult walking behavior (GO:0007628)2.96778903
108positive regulation of synapse maturation (GO:0090129)2.96366568
109regulation of mast cell activation involved in immune response (GO:0033006)2.95918136
110positive regulation of neurotransmitter transport (GO:0051590)2.94950335
111positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.94614923
112postsynaptic membrane organization (GO:0001941)2.94578334
113phagosome maturation (GO:0090382)2.94281919
114alanine transport (GO:0032328)2.94208586
115sodium ion export (GO:0071436)2.94116921
116regulation of myeloid leukocyte mediated immunity (GO:0002886)2.93668484
117regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.92888284
118regulation of synaptic transmission (GO:0050804)2.92645590
119response to peptidoglycan (GO:0032494)2.92474732
120G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.92266409
121long-chain fatty acid biosynthetic process (GO:0042759)2.91602642
122regulation of neurotransmitter levels (GO:0001505)2.91162492
123positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.89614629
124regulation of neurotransmitter transport (GO:0051588)2.89182595
125regulation of ARF protein signal transduction (GO:0032012)2.89044337
126membrane hyperpolarization (GO:0060081)2.88679744
127dendrite morphogenesis (GO:0048813)2.86790184
128NIK/NF-kappaB signaling (GO:0038061)2.86203249
129central nervous system myelination (GO:0022010)2.85873470
130axon ensheathment in central nervous system (GO:0032291)2.85873470
131synaptic transmission (GO:0007268)2.85097911
132cellular response to arsenic-containing substance (GO:0071243)2.84943926
133positive regulation of synaptic transmission (GO:0050806)2.84463317
134cerebellar granule cell differentiation (GO:0021707)2.82944688
135glycine transport (GO:0015816)2.82755802
136positive regulation of dendritic spine morphogenesis (GO:0061003)2.81710085
137mannose metabolic process (GO:0006013)2.81135239
138positive regulation of calcium-mediated signaling (GO:0050850)2.81035756
139fear response (GO:0042596)2.79526840
140regulation of voltage-gated calcium channel activity (GO:1901385)2.78905028
141energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.78460362
142ATP hydrolysis coupled proton transport (GO:0015991)2.78460362
143glycosphingolipid biosynthetic process (GO:0006688)2.77878012
144transferrin transport (GO:0033572)2.77526042
145detection of calcium ion (GO:0005513)2.77240548
146positive regulation of regulated secretory pathway (GO:1903307)2.75380623
147sphingosine metabolic process (GO:0006670)2.73472130
148monocyte chemotaxis (GO:0002548)2.69671801
149lysosome organization (GO:0007040)2.68128625
150lytic vacuole organization (GO:0080171)2.68128625
151regulation of mast cell activation (GO:0033003)2.66821054
152glycosylceramide metabolic process (GO:0006677)2.66253938
153germinal center formation (GO:0002467)2.61637349
154positive regulation of Rap GTPase activity (GO:0032854)2.58948747
155regulation of cholesterol storage (GO:0010885)2.58673713
156barbed-end actin filament capping (GO:0051016)2.58289305
157phosphatidylglycerol biosynthetic process (GO:0006655)2.57379993
158purinergic receptor signaling pathway (GO:0035587)2.56789903
159hydrogen peroxide biosynthetic process (GO:0050665)2.54308638
160cellular response to ATP (GO:0071318)2.53917638
161negative regulation of mast cell activation (GO:0033004)2.51067641
162diol metabolic process (GO:0034311)2.50572103
163regulation of monocyte chemotaxis (GO:0090025)2.48371314
164response to thyroid hormone (GO:0097066)2.47950780
165lipopolysaccharide-mediated signaling pathway (GO:0031663)2.47282750
166ferric iron transport (GO:0015682)2.46891459
167trivalent inorganic cation transport (GO:0072512)2.46891459
168positive regulation of chemokine biosynthetic process (GO:0045080)2.46766276
169adhesion of symbiont to host (GO:0044406)2.43803928
170adhesion of symbiont to host cell (GO:0044650)2.42366274
171virion attachment to host cell (GO:0019062)2.42366274
172response to auditory stimulus (GO:0010996)2.39926096
173regulation of fever generation (GO:0031620)2.38695466

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.91507238
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.46427737
3GBX2_23144817_ChIP-Seq_PC3_Human3.30499326
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.27299352
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21736217
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13543289
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.11928822
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.98459356
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.84810629
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.84810629
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76811298
12REST_21632747_ChIP-Seq_MESCs_Mouse2.74679938
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.73739682
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.70818188
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.69494375
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68638044
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.65694693
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.64529558
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.63358722
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.61734824
21DROSHA_22980978_ChIP-Seq_HELA_Human2.60413362
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.52901499
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52273226
24* LXR_22292898_ChIP-Seq_THP-1_Human2.47093089
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41335401
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.41184644
27IRF8_27001747_Chip-Seq_BMDM_Mouse2.37303976
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.35266728
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.33813181
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.30301726
31AR_21572438_ChIP-Seq_LNCaP_Human2.26265418
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20613190
33* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.19417069
34REST_18959480_ChIP-ChIP_MESCs_Mouse2.18983944
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07242047
36KDM2B_26808549_Chip-Seq_SUP-B15_Human2.03220661
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01196062
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89273401
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.85316910
40* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.84244259
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.81854135
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.77567743
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.77375362
44TAF15_26573619_Chip-Seq_HEK293_Human1.72005743
45VDR_21846776_ChIP-Seq_THP-1_Human1.69329341
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.68824678
47SPI1_23127762_ChIP-Seq_K562_Human1.67623052
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63741385
49* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60667861
50VDR_24763502_ChIP-Seq_THP-1_Human1.58778498
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54233188
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53892659
53BCOR_27268052_Chip-Seq_Bcells_Human1.53610328
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51043317
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50063115
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49664683
57BCL6_27268052_Chip-Seq_Bcells_Human1.48215077
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46537828
59SCL_19346495_ChIP-Seq_HPC-7_Human1.46523852
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.45369810
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45101420
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44024808
63VDR_24787735_ChIP-Seq_THP-1_Human1.43888070
64P68_20966046_ChIP-Seq_HELA_Human1.43669101
65* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43505391
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.43340817
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43250777
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39760707
69SMAD4_21799915_ChIP-Seq_A2780_Human1.39670791
70SMC4_20622854_ChIP-Seq_HELA_Human1.38299462
71* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35400248
72KDM2B_26808549_Chip-Seq_DND41_Human1.34577132
73MYC_22102868_ChIP-Seq_BL_Human1.34200461
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33591207
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.32469670
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32340852
77STAT1_20625510_ChIP-Seq_HELA_Human1.31462361
78* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30747136
79RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29894174
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29584879
81* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28686288
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28093911
83SA1_27219007_Chip-Seq_Bcells_Human1.26103767
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25322483
85* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24273366
86* GATA1_19941827_ChIP-Seq_MEL_Mouse1.22501877
87* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22337226
88* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22109646
89* SMAD3_21741376_ChIP-Seq_EPCs_Human1.21044659
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20970462
91MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19814902
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19461319
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.18655547
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16579381
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16433583
96* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16316900
97NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16122794
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.15282181
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.14285138
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.14110592
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13646387
102VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13328211
103PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13086588
104TP53_16413492_ChIP-PET_HCT116_Human1.12555754
105NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12548705
106ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12308450
107CTCF_20526341_ChIP-Seq_ESCs_Human1.11977992
108CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11953441
109OCT4_19829295_ChIP-Seq_ESCs_Human1.11859924
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11040546
111KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11001374
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09858325
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08983135
114SPI1_20517297_ChIP-Seq_HL60_Human1.07990710
115* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07385607
116* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07297963
117SA1_27219007_Chip-Seq_ERYTHROID_Human1.06691779
118SMAD_19615063_ChIP-ChIP_OVARY_Human1.06316506
119EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05730281
120AR_19668381_ChIP-Seq_PC3_Human1.05548723
121STAT3_23295773_ChIP-Seq_U87_Human1.05469521
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04397979
123P300_19829295_ChIP-Seq_ESCs_Human1.03926983
124TCF7_22412390_ChIP-Seq_EML_Mouse1.03501406
125BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03181010
126KDM2B_26808549_Chip-Seq_K562_Human1.03117503
127TCF4_23295773_ChIP-Seq_U87_Human1.03008058
128P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02452485
129RUNX1_22412390_ChIP-Seq_EML_Mouse1.01689006
130CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01136494
131* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00726415
132VDR_22108803_ChIP-Seq_LS180_Human0.99774442
133TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99312107
134TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98990933
135STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98065994
136AR_25329375_ChIP-Seq_VCAP_Human0.97989648
137ZNF274_21170338_ChIP-Seq_K562_Hela0.97617472
138* MITF_21258399_ChIP-Seq_MELANOMA_Human0.96994216
139TP63_22573176_ChIP-Seq_HFKS_Human0.96730288
140P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.96482125
141FUS_26573619_Chip-Seq_HEK293_Human0.96246591
142CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95467455
143TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94946123
144PRDM14_20953172_ChIP-Seq_ESCs_Human0.94786566
145PHF8_20622854_ChIP-Seq_HELA_Human0.94759021
146SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94723991
147BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94627158
148E2F1_20622854_ChIP-Seq_HELA_Human0.94401464
149PIAS1_25552417_ChIP-Seq_VCAP_Human0.93858298
150ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93797542
151TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.93780085
152* CTCF_27219007_Chip-Seq_Bcells_Human0.93037614
153AHR_22903824_ChIP-Seq_MCF-7_Human0.92226368
154ARNT_22903824_ChIP-Seq_MCF-7_Human0.91149156
155ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89874678
156TET1_21490601_ChIP-Seq_MESCs_Mouse0.89833695
157RNF2_27304074_Chip-Seq_NSC_Mouse0.89468463
158NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89351680
159SMAD3_21741376_ChIP-Seq_HESCs_Human0.89100832
160RUNX2_22187159_ChIP-Seq_PCA_Human0.87562295
161CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87483220
162CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86553029
163YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85211662
164UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84073998
165POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83438767
166TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83438767
167* SMAD3_21741376_ChIP-Seq_ESCs_Human0.82724397
168SMAD4_21741376_ChIP-Seq_HESCs_Human0.81566976
169TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80105159
170TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79729032
171KLF4_19829295_ChIP-Seq_ESCs_Human0.79166830
172GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.78691314
173GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78158746
174GATA1_26923725_Chip-Seq_HPCs_Mouse0.77224937

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.28482149
2MP0003880_abnormal_central_pattern5.56722485
3MP0005058_abnormal_lysosome_morphology4.40482101
4MP0003635_abnormal_synaptic_transmissio4.27051263
5MP0004270_analgesia3.98584330
6MP0009745_abnormal_behavioral_response3.64727608
7MP0002063_abnormal_learning/memory/cond3.36742091
8MP0002064_seizures3.35546122
9MP0003172_abnormal_lysosome_physiology3.32993898
10MP0001968_abnormal_touch/_nociception2.88127240
11MP0002272_abnormal_nervous_system2.81101546
12MP0002572_abnormal_emotion/affect_behav2.79321027
13MP0009046_muscle_twitch2.74879253
14MP0001486_abnormal_startle_reflex2.71383590
15MP0009840_abnormal_foam_cell2.60229304
16MP0002148_abnormal_hypersensitivity_rea2.49117488
17MP0001501_abnormal_sleep_pattern2.45259796
18MP0005423_abnormal_somatic_nervous2.43111065
19MP0002822_catalepsy2.40550483
20MP0006082_CNS_inflammation2.39829197
21MP0002734_abnormal_mechanical_nocicepti2.39206801
22MP0001440_abnormal_grooming_behavior2.34270797
23MP0002736_abnormal_nociception_after2.31693091
24MP0003329_amyloid_beta_deposits2.30950738
25MP0005671_abnormal_response_to2.30642876
26MP0005167_abnormal_blood-brain_barrier2.08630834
27MP0009780_abnormal_chondrocyte_physiolo2.04300928
28MP0005387_immune_system_phenotype1.90004515
29MP0001790_abnormal_immune_system1.90004515
30MP0005000_abnormal_immune_tolerance1.88019511
31MP0003436_decreased_susceptibility_to1.86029062
32MP0002735_abnormal_chemical_nociception1.84860178
33MP0000685_abnormal_immune_system1.83005097
34MP0008569_lethality_at_weaning1.81245708
35MP0001970_abnormal_pain_threshold1.81225990
36MP0000920_abnormal_myelination1.80214885
37MP0002067_abnormal_sensory_capabilities1.80103928
38MP0002733_abnormal_thermal_nociception1.75834728
39MP0002419_abnormal_innate_immunity1.75347364
40MP0003879_abnormal_hair_cell1.74031412
41MP0000343_altered_response_to1.67792408
42MP0004924_abnormal_behavior1.67329927
43MP0005386_behavior/neurological_phenoty1.67329927
44MP0002254_reproductive_system_inflammat1.65344141
45MP0004811_abnormal_neuron_physiology1.62766554
46MP0000778_abnormal_nervous_system1.62465612
47MP0004885_abnormal_endolymph1.59067932
48MP0002557_abnormal_social/conspecific_i1.58526332
49MP0000955_abnormal_spinal_cord1.57393711
50MP0002139_abnormal_hepatobiliary_system1.55690738
51MP0003787_abnormal_imprinting1.55414118
52MP0005025_abnormal_response_to1.55061219
53MP0004142_abnormal_muscle_tone1.53940433
54MP0002452_abnormal_antigen_presenting1.52815632
55MP0002723_abnormal_immune_serum1.50330061
56MP0002184_abnormal_innervation1.49398233
57MP0002066_abnormal_motor_capabilities/c1.48693700
58MP0009785_altered_susceptibility_to1.48658903
59MP0001905_abnormal_dopamine_level1.45397017
60MP0001502_abnormal_circadian_rhythm1.41010186
61MP0002882_abnormal_neuron_morphology1.40310609
62MP0001800_abnormal_humoral_immune1.40232566
63MP0004947_skin_inflammation1.38733800
64MP0001529_abnormal_vocalization1.38616020
65MP0003690_abnormal_glial_cell1.34968980
66MP0003453_abnormal_keratinocyte_physiol1.34334634
67MP0005166_decreased_susceptibility_to1.33136495
68MP0004858_abnormal_nervous_system1.28861138
69MP0004742_abnormal_vestibular_system1.27734156
70MP0002909_abnormal_adrenal_gland1.27441192
71MP0003045_fibrosis1.27326080
72MP0003633_abnormal_nervous_system1.25952063
73MP0002420_abnormal_adaptive_immunity1.25370372
74MP0001819_abnormal_immune_cell1.24237078
75MP0001835_abnormal_antigen_presentation1.23231887
76MP0002998_abnormal_bone_remodeling1.21716490
77MP0005645_abnormal_hypothalamus_physiol1.20739253
78MP0003631_nervous_system_phenotype1.19402928
79MP0003191_abnormal_cellular_cholesterol1.18148945
80MP0004510_myositis1.16854523
81MP0002090_abnormal_vision1.14272291
82MP0000604_amyloidosis1.13600798
83MP0002229_neurodegeneration1.12397513
84MP0002152_abnormal_brain_morphology1.11050741
85MP0001845_abnormal_inflammatory_respons1.10746470
86MP0003183_abnormal_peptide_metabolism1.10473890
87MP0009764_decreased_sensitivity_to1.09515979
88MP0008874_decreased_physiological_sensi1.08848923
89MP0001533_abnormal_skeleton_physiology1.08459789
90MP0003632_abnormal_nervous_system1.06778120
91MP0006276_abnormal_autonomic_nervous1.05354184
92MP0002405_respiratory_system_inflammati1.04621516
93MP0003075_altered_response_to1.04145273
94MP0008961_abnormal_basal_metabolism1.03412630
95MP0001986_abnormal_taste_sensitivity1.02574178
96MP0010234_abnormal_vibrissa_follicle1.01888180
97MP0002796_impaired_skin_barrier1.00093612
98MP0004145_abnormal_muscle_electrophysio0.99873449
99MP0003634_abnormal_glial_cell0.99839528
100MP0003300_gastrointestinal_ulcer0.98791247
101MP0001984_abnormal_olfaction0.96544261
102MP0009333_abnormal_splenocyte_physiolog0.94949274
103MP0002069_abnormal_eating/drinking_beha0.94037810
104MP0001188_hyperpigmentation0.94012708
105MP0005410_abnormal_fertilization0.93268441
106MP0008469_abnormal_protein_level0.92827478
107MP0009278_abnormal_bone_marrow0.92781729
108MP0008872_abnormal_physiological_respon0.91909602
109MP0002138_abnormal_hepatobiliary_system0.91301439
110MP0005646_abnormal_pituitary_gland0.90766660
111MP0005171_absent_coat_pigmentation0.86491553
112MP0004019_abnormal_vitamin_homeostasis0.85302204
113MP0005409_darkened_coat_color0.84993477
114MP0005551_abnormal_eye_electrophysiolog0.84757273
115MP0000716_abnormal_immune_system0.84549946
116MP0010155_abnormal_intestine_physiology0.82894977
117MP0001177_atelectasis0.82152287
118MP0004043_abnormal_pH_regulation0.81929515
119MP0003448_altered_tumor_morphology0.81499384
120MP0000751_myopathy0.81230458
121MP0001963_abnormal_hearing_physiology0.80429701
122MP0001485_abnormal_pinna_reflex0.80305178
123MP0005623_abnormal_meninges_morphology0.78822575
124MP0003195_calcinosis0.77892649
125MP0003303_peritoneal_inflammation0.77109668
126MP0004381_abnormal_hair_follicle0.75111977
127MP0003122_maternal_imprinting0.74839124
128MP0002752_abnormal_somatic_nervous0.74775802
129MP0002098_abnormal_vibrissa_morphology0.71518094
130MP0001853_heart_inflammation0.70931140
131MP0005310_abnormal_salivary_gland0.65561119
132MP0001765_abnormal_ion_homeostasis0.62946685
133MP0010386_abnormal_urinary_bladder0.62616917
134MP0005535_abnormal_body_temperature0.62381783
135MP0004085_abnormal_heartbeat0.60730380
136MP0004484_altered_response_of0.59356291
137MP0001664_abnormal_digestion0.59080688
138MP0000747_muscle_weakness0.58075585
139MP0000013_abnormal_adipose_tissue0.56088232
140MP0010678_abnormal_skin_adnexa0.55444583
141MP0000003_abnormal_adipose_tissue0.54455401
142MP0003861_abnormal_nervous_system0.53330716
143MP0001943_abnormal_respiration0.53296097
144MP0010769_abnormal_survival0.53184659
145MP0010768_mortality/aging0.49960763
146MP0003956_abnormal_body_size0.48909640
147MP0010770_preweaning_lethality0.48693337
148MP0002082_postnatal_lethality0.48693337
149MP0002837_dystrophic_cardiac_calcinosis0.48010166
150MP0000026_abnormal_inner_ear0.46812301
151MP0000631_abnormal_neuroendocrine_gland0.45882905

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.54683908
2Abnormality of glycolipid metabolism (HP:0010969)7.48287777
3Abnormality of liposaccharide metabolism (HP:0010968)7.48287777
4Abnormality of glycosphingolipid metabolism (HP:0004343)7.48287777
5Myokymia (HP:0002411)7.13095441
6Increased cerebral lipofuscin (HP:0011813)5.91264049
7Vacuolated lymphocytes (HP:0001922)5.82214437
8Focal seizures (HP:0007359)5.75951875
9Scanning speech (HP:0002168)5.30243125
10Increased neuronal autofluorescent lipopigment (HP:0002074)5.09096629
11Atonic seizures (HP:0010819)5.02680340
12Disinhibition (HP:0000734)4.98737499
13Epileptic encephalopathy (HP:0200134)4.76382001
14Visual hallucinations (HP:0002367)4.72722109
15Dysostosis multiplex (HP:0000943)4.66271573
16Axonal loss (HP:0003447)4.17343842
17Supranuclear gaze palsy (HP:0000605)4.16599986
18Progressive cerebellar ataxia (HP:0002073)4.09783682
19Dysmetria (HP:0001310)4.05030846
20Absence seizures (HP:0002121)4.04527379
21Febrile seizures (HP:0002373)4.00981797
22Loss of speech (HP:0002371)3.89374896
23Neurofibrillary tangles (HP:0002185)3.88885710
24Apathy (HP:0000741)3.83385718
25Cerebral inclusion bodies (HP:0100314)3.79666485
26Dialeptic seizures (HP:0011146)3.79446790
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.71672860
28Diminished motivation (HP:0000745)3.67432788
29Systemic lupus erythematosus (HP:0002725)3.67005497
30Agnosia (HP:0010524)3.63741877
31Postural instability (HP:0002172)3.62606967
32Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.59720231
33Inappropriate behavior (HP:0000719)3.51239529
34Generalized tonic-clonic seizures (HP:0002069)3.48520005
35Abnormality of mucopolysaccharide metabolism (HP:0011020)3.48284036
36Abnormality of polysaccharide metabolism (HP:0011012)3.48284036
37Abnormality of glycosaminoglycan metabolism (HP:0004371)3.48284036
38Gaze-evoked nystagmus (HP:0000640)3.46995932
39Broad-based gait (HP:0002136)3.41830844
40Impaired vibration sensation in the lower limbs (HP:0002166)3.41288216
41Degeneration of the lateral corticospinal tracts (HP:0002314)3.41010773
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.41010773
43Urinary bladder sphincter dysfunction (HP:0002839)3.40732882
44Spastic gait (HP:0002064)3.37479351
45Ankle clonus (HP:0011448)3.37310815
46Dysdiadochokinesis (HP:0002075)3.26607256
47Abnormality of the corticospinal tract (HP:0002492)3.22989608
48Mucopolysacchariduria (HP:0008155)3.21341849
49Urinary glycosaminoglycan excretion (HP:0003541)3.21341849
50Action tremor (HP:0002345)3.15958126
51Hyperventilation (HP:0002883)3.08452875
52Intention tremor (HP:0002080)3.07894949
53Global brain atrophy (HP:0002283)3.07700540
54Amblyopia (HP:0000646)2.97943797
55Truncal ataxia (HP:0002078)2.95492336
56Poor eye contact (HP:0000817)2.93410206
57Depression (HP:0000716)2.89847119
58Urinary urgency (HP:0000012)2.85944978
59Personality changes (HP:0000751)2.83746242
60Anxiety (HP:0000739)2.81519284
61Abnormality of macrophages (HP:0004311)2.78145768
62Nuclear cataract (HP:0100018)2.73501942
63Dementia (HP:0000726)2.73168978
64Abnormality of the vasculature of the conjunctiva (HP:0008054)2.69867350
65Genetic anticipation (HP:0003743)2.69523089
66Impaired social interactions (HP:0000735)2.68850534
67Abnormal social behavior (HP:0012433)2.68850534
68Sensory axonal neuropathy (HP:0003390)2.67751643
69Glomerulonephritis (HP:0000099)2.66529543
70Upper motor neuron abnormality (HP:0002127)2.65519998
71Autoimmune thrombocytopenia (HP:0001973)2.65340485
72Retinal atrophy (HP:0001105)2.63475721
73Insidious onset (HP:0003587)2.55924562
74Termporal pattern (HP:0011008)2.55924562
75Fetal akinesia sequence (HP:0001989)2.55638651
76Impaired smooth pursuit (HP:0007772)2.55013828
77Recurrent bacterial skin infections (HP:0005406)2.49642965
78Abnormal eating behavior (HP:0100738)2.49482666
79Hemiparesis (HP:0001269)2.43328185
80Impaired vibratory sensation (HP:0002495)2.43029321
81Hemiplegia (HP:0002301)2.40484659
82Generalized myoclonic seizures (HP:0002123)2.40228590
83Insomnia (HP:0100785)2.39692787
84Delusions (HP:0000746)2.38349270
85Peripheral hypomyelination (HP:0007182)2.37542201
86Abnormality of binocular vision (HP:0011514)2.37532730
87Diplopia (HP:0000651)2.37532730
88Absent speech (HP:0001344)2.36996230
89Papilledema (HP:0001085)2.36608099
90Bradykinesia (HP:0002067)2.33068588
91Akinesia (HP:0002304)2.32880910
92Eczematoid dermatitis (HP:0000976)2.32763339
93Lower limb muscle weakness (HP:0007340)2.31346776
94Memory impairment (HP:0002354)2.30458047
95Stereotypic behavior (HP:0000733)2.27659033
96Recurrent abscess formation (HP:0002722)2.26506732
97Excessive salivation (HP:0003781)2.23184200
98Drooling (HP:0002307)2.23184200
99Agitation (HP:0000713)2.16597045
100Mutism (HP:0002300)2.16309220
101Hematochezia (HP:0002573)2.15643604
102Status epilepticus (HP:0002133)2.14198120
103Epileptiform EEG discharges (HP:0011182)2.14120074
104Urinary incontinence (HP:0000020)2.13048304
105Neoplasm of the adrenal cortex (HP:0100641)2.12313917
106Cerebral aneurysm (HP:0004944)2.10951549
107Progressive neurologic deterioration (HP:0002344)2.10042231
108Mediastinal lymphadenopathy (HP:0100721)2.09886271
109Abnormality of the lower motor neuron (HP:0002366)2.08134977
110Torticollis (HP:0000473)2.07790056
111Retinal dysplasia (HP:0007973)2.07720601
112Abnormality of ocular smooth pursuit (HP:0000617)2.07109538
113Dysmetric saccades (HP:0000641)2.06649548
114Thickened helices (HP:0000391)2.05092774
115Abnormality of the periventricular white matter (HP:0002518)2.05090780
116Lower limb amyotrophy (HP:0007210)2.04163223
117Focal dystonia (HP:0004373)2.03140417
118Onion bulb formation (HP:0003383)2.02047546
119Cardiomegaly (HP:0001640)2.01860114
120Progressive inability to walk (HP:0002505)2.01386696
121Abnormality of saccadic eye movements (HP:0000570)2.00505983
122Slow saccadic eye movements (HP:0000514)1.99778953
123Type II lissencephaly (HP:0007260)1.99754621
124Dynein arm defect of respiratory motile cilia (HP:0012255)1.99656410
125Absent/shortened dynein arms (HP:0200106)1.99656410
126EEG with generalized epileptiform discharges (HP:0011198)1.99300589
127Megalencephaly (HP:0001355)1.96368069
128Polyphagia (HP:0002591)1.94114503
129Psychosis (HP:0000709)1.94028750
130Annular pancreas (HP:0001734)1.93942197
131Sensorimotor neuropathy (HP:0007141)1.93094351
132Clonus (HP:0002169)1.93025386
133Rigidity (HP:0002063)1.89986808
134Neuronal loss in central nervous system (HP:0002529)1.89486919
135Abnormality of salivation (HP:0100755)1.89389190
136Hypsarrhythmia (HP:0002521)1.89152738
137Progressive visual loss (HP:0000529)1.86957162
138Stomach cancer (HP:0012126)1.86627126
139Spastic tetraparesis (HP:0001285)1.86469567
140Complement deficiency (HP:0004431)1.86249811
141J-shaped sella turcica (HP:0002680)1.84915910
142Basal ganglia calcification (HP:0002135)1.84860224
143Incomplete penetrance (HP:0003829)1.84523313
144Peripheral demyelination (HP:0011096)1.84519213
145Metaphyseal irregularity (HP:0003025)1.84325418
146Clumsiness (HP:0002312)1.82425562
147Widely spaced teeth (HP:0000687)1.81910028
148Blue irides (HP:0000635)1.81475803
149Thoracic kyphosis (HP:0002942)1.80512810
150Pointed chin (HP:0000307)1.79853673
151Ankyloglossia (HP:0010296)1.78917739
152Macroglossia (HP:0000158)1.77092775
153Specific learning disability (HP:0001328)1.76135251
154Rapidly progressive (HP:0003678)1.74739451
155Cerebral hypomyelination (HP:0006808)1.74335005
156Purpura (HP:0000979)1.73555638
157Ventricular fibrillation (HP:0001663)1.70487560
158Myoclonus (HP:0001336)1.69177023
159Stomatitis (HP:0010280)1.67486950
160Pathologic fracture (HP:0002756)1.62938685
161Dysphonia (HP:0001618)1.58540520
162Increased IgE level (HP:0003212)1.58500815
163Abnormality of chloride homeostasis (HP:0011422)1.54396067
164Limb ataxia (HP:0002070)1.54025051
165Recurrent gram-negative bacterial infections (HP:0005420)1.53500391
166Increased CSF protein (HP:0002922)1.53306941

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.14274982
2NTRK34.10814721
3MAP3K93.87608578
4NME22.79497730
5MAP3K112.71506983
6RIPK42.67972734
7IRAK32.51393311
8BLK2.36495117
9PAK62.34733483
10DAPK22.34048671
11KSR22.33923545
12MINK12.19440220
13MAP3K132.19096686
14MAP3K42.16095362
15PRPF4B2.14923433
16CDK192.11820997
17ACVR1B2.04198733
18TNIK2.04183577
19CAMK1D2.03637524
20ARAF1.90689278
21OXSR11.85671176
22PRKCH1.78442426
23MAP3K141.78292339
24NTRK11.71013915
25GRK71.69240402
26PNCK1.68831900
27MARK11.67553572
28MAP2K71.64796833
29PRKD31.64041541
30STK391.62165637
31CDK51.55268051
32RIPK11.52692305
33FES1.50094147
34KSR11.46027888
35TYRO31.45697136
36TGFBR21.45382757
37PLK21.43875753
38TBK11.43446778
39NTRK21.43113184
40CAMKK11.42835977
41ERN11.42791626
42IKBKB1.41179928
43MAP4K11.38860874
44TESK11.34044418
45ADRBK21.33372153
46MAP3K121.32774230
47PIM21.31249622
48DDR21.29621962
49TAOK21.29273592
50DAPK11.27604624
51FGR1.26804423
52PTK2B1.25794424
53TESK21.24604239
54CDC42BPA1.24269846
55SIK21.22986182
56MAP2K41.21199473
57LIMK11.20731505
58TGFBR11.19745757
59ZAK1.17825216
60UHMK11.17346283
61CAMK2B1.17142991
62RAF11.14386954
63GRK51.12881113
64MAP3K21.11532055
65STK381.09034282
66MAP2K61.08177702
67CSF1R1.07812260
68SYK1.06360526
69CAMK11.05003643
70CAMK2A1.04921539
71CASK1.03944630
72PRKCG1.03639916
73BMPR21.01138582
74ALK0.99913635
75NEK60.97539143
76MAP3K70.96590449
77ABL20.96341479
78PAK30.94726903
79CDK150.93913392
80CDK180.92416642
81CDK140.91912516
82STK110.90720483
83NME10.90541851
84ICK0.89326351
85TNK20.88744215
86MARK20.88049300
87MAP3K30.87327285
88PDK10.83114053
89CDK11A0.82163716
90TYK20.80923535
91PDPK10.80128921
92CAMK40.80123104
93TXK0.79524895
94TAOK10.78872053
95WNK40.77200599
96BRAF0.76748182
97SIK30.71378548
98SIK10.70395333
99CAMK2D0.70366856
100PKN10.69567778
101WNK10.69076547
102TLK10.67438585
103MAP3K10.67289109
104DYRK1A0.67057721
105SGK10.66710900
106CLK10.65875778
107CSNK1G20.65565922
108SGK4940.65348853
109SGK2230.65348853
110MAPK120.63267066
111ROCK20.63256791
112GRK60.61347443
113MAPK130.60643566
114BCR0.60617579
115CAMK2G0.59965709
116PRKCQ0.59763912
117FYN0.59210204
118RET0.56209374
119MATK0.55697759
120CAMKK20.54971688
121DAPK30.54274985
122LYN0.53451210
123PRKD20.52142029
124CSK0.51721108
125DMPK0.49883181
126CHUK0.48864500
127IRAK20.44794566
128ZAP700.44243186
129IKBKE0.43717098
130JAK10.43622614
131CSNK1A1L0.43358740
132MAP2K20.42814325
133RPS6KA30.41271926
134IRAK40.39379723
135PRKCE0.39325196
136CAMK1G0.38947332
137JAK20.38923959
138CSNK1E0.38619305
139FER0.37532991
140MAPK100.37190369
141PINK10.35442532
142MOS0.33535984
143CSNK1G30.33459852
144PRKCZ0.32547227
145PRKCA0.30739184
146FGFR20.29399434

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.96826682
2Nicotine addiction_Homo sapiens_hsa050333.76618694
3Lysosome_Homo sapiens_hsa041423.75866243
4Synaptic vesicle cycle_Homo sapiens_hsa047213.10092322
5Long-term potentiation_Homo sapiens_hsa047202.82877307
6Glutamatergic synapse_Homo sapiens_hsa047242.79395596
7Circadian entrainment_Homo sapiens_hsa047132.75140964
8Olfactory transduction_Homo sapiens_hsa047402.73587521
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72997186
10Morphine addiction_Homo sapiens_hsa050322.59850112
11GABAergic synapse_Homo sapiens_hsa047272.57334938
12Amphetamine addiction_Homo sapiens_hsa050312.50161342
13Salivary secretion_Homo sapiens_hsa049702.37377310
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.26737865
15Staphylococcus aureus infection_Homo sapiens_hsa051502.12191331
16Glycosaminoglycan degradation_Homo sapiens_hsa005312.03740028
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03675806
18Dopaminergic synapse_Homo sapiens_hsa047282.00054227
19Gastric acid secretion_Homo sapiens_hsa049711.98717385
20Osteoclast differentiation_Homo sapiens_hsa043801.95866343
21Long-term depression_Homo sapiens_hsa047301.89980664
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88259574
23Insulin secretion_Homo sapiens_hsa049111.88254132
24Asthma_Homo sapiens_hsa053101.87849857
25Tuberculosis_Homo sapiens_hsa051521.82084303
26Cholinergic synapse_Homo sapiens_hsa047251.81299222
27Oxytocin signaling pathway_Homo sapiens_hsa049211.72785550
28Calcium signaling pathway_Homo sapiens_hsa040201.69092094
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.68736321
30Serotonergic synapse_Homo sapiens_hsa047261.67593620
31Taste transduction_Homo sapiens_hsa047421.66833300
32Collecting duct acid secretion_Homo sapiens_hsa049661.63001430
33Renin secretion_Homo sapiens_hsa049241.59597962
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.55240171
35Allograft rejection_Homo sapiens_hsa053301.54757609
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53891955
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49025955
38GnRH signaling pathway_Homo sapiens_hsa049121.48243928
39Leishmaniasis_Homo sapiens_hsa051401.44175942
40Cocaine addiction_Homo sapiens_hsa050301.41583603
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.39128022
42Axon guidance_Homo sapiens_hsa043601.36660530
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36433303
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32365428
45Pertussis_Homo sapiens_hsa051331.30816312
46Autoimmune thyroid disease_Homo sapiens_hsa053201.30039444
47cAMP signaling pathway_Homo sapiens_hsa040241.29409480
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26924775
49Gap junction_Homo sapiens_hsa045401.26694314
50Salmonella infection_Homo sapiens_hsa051321.24546711
51Phagosome_Homo sapiens_hsa041451.24478182
52Melanogenesis_Homo sapiens_hsa049161.23545166
53Graft-versus-host disease_Homo sapiens_hsa053321.21815514
54Antigen processing and presentation_Homo sapiens_hsa046121.16738334
55NF-kappa B signaling pathway_Homo sapiens_hsa040641.14804674
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13260527
57ErbB signaling pathway_Homo sapiens_hsa040121.13174195
58Sphingolipid metabolism_Homo sapiens_hsa006001.12652216
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10076745
60Estrogen signaling pathway_Homo sapiens_hsa049151.08356337
61Glioma_Homo sapiens_hsa052141.07799067
62Vibrio cholerae infection_Homo sapiens_hsa051101.06941424
63Vascular smooth muscle contraction_Homo sapiens_hsa042701.04851081
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03143337
65Dorso-ventral axis formation_Homo sapiens_hsa043201.01696476
66Phospholipase D signaling pathway_Homo sapiens_hsa040721.01412386
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00837237
68TNF signaling pathway_Homo sapiens_hsa046681.00410228
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98040607
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96136988
71Pancreatic secretion_Homo sapiens_hsa049720.93049195
72Type II diabetes mellitus_Homo sapiens_hsa049300.90862368
73Choline metabolism in cancer_Homo sapiens_hsa052310.90457214
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89758782
75Toxoplasmosis_Homo sapiens_hsa051450.83651845
76Mineral absorption_Homo sapiens_hsa049780.82068627
77Cardiac muscle contraction_Homo sapiens_hsa042600.80762610
78Oocyte meiosis_Homo sapiens_hsa041140.78661020
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78594646
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77490577
81MAPK signaling pathway_Homo sapiens_hsa040100.76977337
82VEGF signaling pathway_Homo sapiens_hsa043700.73138046
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72610998
84Primary immunodeficiency_Homo sapiens_hsa053400.72519849
85Thyroid hormone synthesis_Homo sapiens_hsa049180.72442968
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.70459419
87Vitamin B6 metabolism_Homo sapiens_hsa007500.69104398
88Hematopoietic cell lineage_Homo sapiens_hsa046400.68416482
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68264933
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66309242
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64897546
92Legionellosis_Homo sapiens_hsa051340.64724168
93* Ras signaling pathway_Homo sapiens_hsa040140.64138417
94Phototransduction_Homo sapiens_hsa047440.63462156
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60391352
96Endocytosis_Homo sapiens_hsa041440.60269808
97Inositol phosphate metabolism_Homo sapiens_hsa005620.60102249
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57855098
99Dilated cardiomyopathy_Homo sapiens_hsa054140.56852334
100Nitrogen metabolism_Homo sapiens_hsa009100.56154429
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56076259
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55943137
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53539457
104Chemokine signaling pathway_Homo sapiens_hsa040620.52821883
105Wnt signaling pathway_Homo sapiens_hsa043100.52074256
106Renal cell carcinoma_Homo sapiens_hsa052110.50977778
107Alcoholism_Homo sapiens_hsa050340.49555433
108Rap1 signaling pathway_Homo sapiens_hsa040150.49291811
109B cell receptor signaling pathway_Homo sapiens_hsa046620.49167957
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49005221
111Malaria_Homo sapiens_hsa051440.46528669
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46431469
113African trypanosomiasis_Homo sapiens_hsa051430.46194489
114Bladder cancer_Homo sapiens_hsa052190.45455586
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45199481
116Alzheimers disease_Homo sapiens_hsa050100.42779488
117T cell receptor signaling pathway_Homo sapiens_hsa046600.42521511
118Non-small cell lung cancer_Homo sapiens_hsa052230.42401179
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42388513
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.42302689
121Histidine metabolism_Homo sapiens_hsa003400.42285321
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42104455
123Influenza A_Homo sapiens_hsa051640.39642632
124Prion diseases_Homo sapiens_hsa050200.39130774
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38856931
126Shigellosis_Homo sapiens_hsa051310.38665947
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38619492
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38401180
129Glucagon signaling pathway_Homo sapiens_hsa049220.36521394
130Ovarian steroidogenesis_Homo sapiens_hsa049130.36085854
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.34901483
132Bile secretion_Homo sapiens_hsa049760.33516014
133Rheumatoid arthritis_Homo sapiens_hsa053230.32998833
134Type I diabetes mellitus_Homo sapiens_hsa049400.32613225
135Ether lipid metabolism_Homo sapiens_hsa005650.30229966
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29741348
137Platelet activation_Homo sapiens_hsa046110.25449647
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25398106
139Tight junction_Homo sapiens_hsa045300.24451349

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