RASAL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.57926169
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.25954819
3vocalization behavior (GO:0071625)4.13937482
4neuronal action potential propagation (GO:0019227)4.07845810
5synaptic vesicle maturation (GO:0016188)4.04635080
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.02933324
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.97330053
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.95633977
9glutamate secretion (GO:0014047)3.89977179
10ionotropic glutamate receptor signaling pathway (GO:0035235)3.89175933
11protein localization to synapse (GO:0035418)3.82738496
12neuron cell-cell adhesion (GO:0007158)3.82144019
13locomotory exploration behavior (GO:0035641)3.81722498
14synaptic vesicle exocytosis (GO:0016079)3.76053518
15neuron recognition (GO:0008038)3.73854326
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.72178155
17axonal fasciculation (GO:0007413)3.70806746
18pyrimidine nucleobase catabolic process (GO:0006208)3.66257430
19membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.65101942
20regulation of glutamate receptor signaling pathway (GO:1900449)3.65021852
21dendritic spine morphogenesis (GO:0060997)3.56436801
22glutamate receptor signaling pathway (GO:0007215)3.55235684
23regulation of synaptic vesicle exocytosis (GO:2000300)3.55081912
24synaptic transmission, glutamatergic (GO:0035249)3.41767049
25layer formation in cerebral cortex (GO:0021819)3.40732708
26regulation of neuronal synaptic plasticity (GO:0048168)3.33236270
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.28513840
28dendrite morphogenesis (GO:0048813)3.26732145
29neuron-neuron synaptic transmission (GO:0007270)3.22710228
30lymphangiogenesis (GO:0001946)3.19076114
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.16552609
32regulation of postsynaptic membrane potential (GO:0060078)3.15090421
33regulation of synaptic vesicle transport (GO:1902803)3.10654194
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.09802679
35regulation of dendritic spine morphogenesis (GO:0061001)3.09022878
36presynaptic membrane assembly (GO:0097105)3.07778208
37exploration behavior (GO:0035640)3.06686678
38cerebellar Purkinje cell differentiation (GO:0021702)3.06144407
39negative regulation of axon extension involved in axon guidance (GO:0048843)3.04610341
40establishment of nucleus localization (GO:0040023)3.03942923
41neurotransmitter-gated ion channel clustering (GO:0072578)3.03405594
42negative regulation of axon guidance (GO:1902668)3.01132960
43cell migration in hindbrain (GO:0021535)3.00976532
44nucleobase catabolic process (GO:0046113)2.96150205
45regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95298127
46presynaptic membrane organization (GO:0097090)2.93314257
47innervation (GO:0060384)2.91543732
48artery development (GO:0060840)2.90570891
49regulation of synapse structural plasticity (GO:0051823)2.89869673
50neurotransmitter secretion (GO:0007269)2.88225498
51long-term memory (GO:0007616)2.88123403
52G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.84297204
53ganglion development (GO:0061548)2.81142868
54membrane depolarization during action potential (GO:0086010)2.80313391
55membrane hyperpolarization (GO:0060081)2.77858460
56regulation of synaptic plasticity (GO:0048167)2.77792137
57central nervous system projection neuron axonogenesis (GO:0021952)2.77174227
58gamma-aminobutyric acid transport (GO:0015812)2.76639279
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.76605196
60positive regulation of cardiac muscle cell differentiation (GO:2000727)2.76603747
61neuron projection extension involved in neuron projection guidance (GO:1902284)2.76140272
62axon extension involved in axon guidance (GO:0048846)2.76140272
63limb bud formation (GO:0060174)2.74245152
64retinal ganglion cell axon guidance (GO:0031290)2.73044907
65startle response (GO:0001964)2.72846838
66dendritic spine organization (GO:0097061)2.72123821
67transmission of nerve impulse (GO:0019226)2.71650801
68regulation of dendritic spine development (GO:0060998)2.71008087
69positive regulation of neurotransmitter secretion (GO:0001956)2.70054237
70central nervous system neuron axonogenesis (GO:0021955)2.69603200
71membrane depolarization (GO:0051899)2.69297237
72regulation of axon extension involved in axon guidance (GO:0048841)2.68581778
73cellular potassium ion homeostasis (GO:0030007)2.68242739
74regulation of synaptic transmission, glutamatergic (GO:0051966)2.68020085
75long-term synaptic potentiation (GO:0060291)2.67905208
76neuronal ion channel clustering (GO:0045161)2.67191190
77positive regulation of membrane potential (GO:0045838)2.66804418
78regulation of neurotransmitter secretion (GO:0046928)2.66069531
79cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.65068113
80negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.64273924
81regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.63449421
82regulation of voltage-gated calcium channel activity (GO:1901385)2.62754525
83regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.61957025
84positive regulation of synapse maturation (GO:0090129)2.61738724
85atrial cardiac muscle cell action potential (GO:0086014)2.60674869
86neuron projection extension (GO:1990138)2.59837888
87negative regulation of synaptic transmission, GABAergic (GO:0032229)2.58677925
88gamma-aminobutyric acid signaling pathway (GO:0007214)2.58051797
89vesicle transport along microtubule (GO:0047496)2.57821074
90regulation of vesicle fusion (GO:0031338)2.57661933
91chemosensory behavior (GO:0007635)2.57592798
92cell communication by electrical coupling (GO:0010644)2.57347206
93membrane assembly (GO:0071709)2.57283557
94activation of protein kinase A activity (GO:0034199)2.53529100
95positive regulation of neurotransmitter transport (GO:0051590)2.52487087
96negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51267719
97synapse assembly (GO:0007416)2.49685085
98axon extension (GO:0048675)2.49245842
99dendrite development (GO:0016358)2.49100171
100synaptic vesicle endocytosis (GO:0048488)2.48714553
101negative chemotaxis (GO:0050919)2.48596746
102regulation of axon guidance (GO:1902667)2.47978273
103regulation of hippo signaling (GO:0035330)2.47058996
104behavioral fear response (GO:0001662)2.47006580
105behavioral defense response (GO:0002209)2.47006580
106organelle transport along microtubule (GO:0072384)2.46511010
107L-amino acid import (GO:0043092)2.46470332
108postsynaptic membrane organization (GO:0001941)2.46366492
109proline transport (GO:0015824)2.45540942
110negative regulation of protein localization to cell surface (GO:2000009)2.45157216
111calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.44801468
112cerebral cortex radially oriented cell migration (GO:0021799)2.44524527
113synapse organization (GO:0050808)2.44345273
114neuromuscular process controlling balance (GO:0050885)2.44328149
115detection of calcium ion (GO:0005513)2.44045058
116neurotransmitter transport (GO:0006836)2.43703246
117regulation of respiratory system process (GO:0044065)2.43650767
118positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.43029775
119cochlea development (GO:0090102)2.42690508
120positive regulation of dendritic spine development (GO:0060999)2.42236640
121regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.41934494
122auditory behavior (GO:0031223)2.40741393
123positive regulation of synapse assembly (GO:0051965)2.39416213
124behavioral response to ethanol (GO:0048149)2.38899751
125hindbrain development (GO:0030902)2.36848757
126positive regulation of action potential (GO:0045760)2.35371681
127retina layer formation (GO:0010842)2.32722489
128cerebral cortex cell migration (GO:0021795)2.32553036
129regulation of synapse assembly (GO:0051963)2.30976560
130regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.30582329
131inner ear receptor cell development (GO:0060119)2.28768675
132retina vasculature morphogenesis in camera-type eye (GO:0061299)2.28567561
133negative regulation of dendrite development (GO:2000171)2.25912311
134regulation of sarcomere organization (GO:0060297)2.24455190
135negative regulation of systemic arterial blood pressure (GO:0003085)2.24041949
136positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.18690798
137nerve growth factor signaling pathway (GO:0038180)2.17512559
138behavioral response to nicotine (GO:0035095)2.17416945
139protein K11-linked deubiquitination (GO:0035871)2.17092566
140spinal cord development (GO:0021510)2.16929017
141inner ear receptor stereocilium organization (GO:0060122)2.16841378
142negative regulation of axon extension (GO:0030517)2.15735877
143homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.13653837
144negative regulation of keratinocyte proliferation (GO:0010839)2.13539604
145positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.10968911
146response to pheromone (GO:0019236)2.10298937
147apical protein localization (GO:0045176)2.10131767
148response to auditory stimulus (GO:0010996)2.06263891
149sympathetic nervous system development (GO:0048485)2.05804128
150specification of organ identity (GO:0010092)2.05173768
151regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.05038625
152chondrocyte proliferation (GO:0035988)2.04992391
153C4-dicarboxylate transport (GO:0015740)2.02766798
154righting reflex (GO:0060013)2.02709925
155regulation of action potential (GO:0098900)2.01741825
156cell adhesion mediated by integrin (GO:0033627)2.01397506
157nucleus localization (GO:0051647)2.01242733
158hemidesmosome assembly (GO:0031581)2.00896397
159regulation of cell communication by electrical coupling (GO:0010649)1.99286706
160cell communication involved in cardiac conduction (GO:0086065)1.99267700
161embryonic foregut morphogenesis (GO:0048617)1.99260971
162plasma membrane repair (GO:0001778)1.99064731
163regulation of synapse organization (GO:0050807)1.98866927

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.49253432
2GBX2_23144817_ChIP-Seq_PC3_Human3.71566894
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.68528235
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62944886
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60226114
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39876337
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39876337
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.31587402
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30290847
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23083347
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.18208221
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18195458
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16438314
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.15381066
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12871933
16DROSHA_22980978_ChIP-Seq_HELA_Human2.09851714
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03831881
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99166620
19RNF2_27304074_Chip-Seq_ESCs_Mouse1.95836321
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95393443
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.87540442
22REST_21632747_ChIP-Seq_MESCs_Mouse1.85058938
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83535226
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75307682
25AR_21572438_ChIP-Seq_LNCaP_Human1.73969633
26* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72725631
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.69781004
28* SMAD4_21799915_ChIP-Seq_A2780_Human1.69130037
29TAF15_26573619_Chip-Seq_HEK293_Human1.68818711
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66506326
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.63429357
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62023531
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60121113
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59914915
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55670540
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54797669
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.50375318
38P300_19829295_ChIP-Seq_ESCs_Human1.49502623
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49458881
40EWS_26573619_Chip-Seq_HEK293_Human1.49150710
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.48525024
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46703353
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.45056636
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44141655
45* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43512536
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42570874
47* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42361024
48CJUN_26792858_Chip-Seq_BT549_Human1.41262114
49AHR_22903824_ChIP-Seq_MCF-7_Human1.40605819
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.38666600
51* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38398307
52* STAT3_23295773_ChIP-Seq_U87_Human1.34282847
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.33864493
54* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33799124
55ZNF274_21170338_ChIP-Seq_K562_Hela1.33561149
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.33279354
57TP53_16413492_ChIP-PET_HCT116_Human1.33246247
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30717611
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30717611
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.30580509
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30248475
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29904236
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29083174
64CBP_20019798_ChIP-Seq_JUKART_Human1.28855982
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28855982
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27069529
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26170681
68CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25613290
69IGF1R_20145208_ChIP-Seq_DFB_Human1.23977034
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22536941
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21538036
72* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20782873
73FUS_26573619_Chip-Seq_HEK293_Human1.20568452
74* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20121219
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.19934050
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19427046
77TCF4_23295773_ChIP-Seq_U87_Human1.19402560
78LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18012351
79* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17886261
80AR_25329375_ChIP-Seq_VCAP_Human1.17595320
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16981639
82* AR_19668381_ChIP-Seq_PC3_Human1.16528626
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16157758
84RING1B_27294783_Chip-Seq_NPCs_Mouse1.16129031
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15824296
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.14080642
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13734198
88KDM2B_26808549_Chip-Seq_REH_Human1.13604410
89TP53_18474530_ChIP-ChIP_U2OS_Human1.13351172
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12611036
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11731269
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10944189
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09475950
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09174438
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09174438
96* E2F1_18555785_Chip-Seq_ESCs_Mouse1.08447230
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08418604
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08310908
99BCAT_22108803_ChIP-Seq_LS180_Human1.07676421
100* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07470446
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07428893
102TCF4_22108803_ChIP-Seq_LS180_Human1.06281448
103RUNX2_22187159_ChIP-Seq_PCA_Human1.06009278
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05557682
105SOX9_26525672_Chip-Seq_HEART_Mouse1.04753431
106VDR_22108803_ChIP-Seq_LS180_Human1.03773117
107RNF2_27304074_Chip-Seq_NSC_Mouse1.03713474
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01126974
109* NANOG_18555785_Chip-Seq_ESCs_Mouse1.00134373
110* SMAD3_21741376_ChIP-Seq_HESCs_Human0.99921991
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99624004
112P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98758670
113* ER_23166858_ChIP-Seq_MCF-7_Human0.98714696
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98565475
115PRDM14_20953172_ChIP-Seq_ESCs_Human0.98355649
116* SMAD4_21741376_ChIP-Seq_HESCs_Human0.98321471
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97623629
118ERG_21242973_ChIP-ChIP_JURKAT_Human0.97063334
119TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95201492
120RXR_22108803_ChIP-Seq_LS180_Human0.89654325
121STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89546421
122SMAD3_21741376_ChIP-Seq_ESCs_Human0.89527127

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.11902955
2MP0003880_abnormal_central_pattern4.13258940
3MP0004270_analgesia3.43760271
4MP0003635_abnormal_synaptic_transmissio3.25767200
5MP0001968_abnormal_touch/_nociception2.66968087
6MP0002063_abnormal_learning/memory/cond2.64297339
7MP0009046_muscle_twitch2.54174104
8MP0009745_abnormal_behavioral_response2.51820164
9MP0002064_seizures2.45277132
10MP0001486_abnormal_startle_reflex2.38382400
11MP0005423_abnormal_somatic_nervous2.31229619
12MP0002734_abnormal_mechanical_nocicepti2.30663574
13MP0002272_abnormal_nervous_system2.28405564
14MP0000778_abnormal_nervous_system2.24920234
15MP0002572_abnormal_emotion/affect_behav2.22697054
16MP0002735_abnormal_chemical_nociception1.88199106
17MP0000751_myopathy1.84567649
18MP0002067_abnormal_sensory_capabilities1.81819706
19MP0010368_abnormal_lymphatic_system1.77820453
20MP0005623_abnormal_meninges_morphology1.74749292
21MP0001440_abnormal_grooming_behavior1.74636956
22MP0002736_abnormal_nociception_after1.73733437
23MP0002184_abnormal_innervation1.69541005
24MP0009780_abnormal_chondrocyte_physiolo1.60415503
25MP0008569_lethality_at_weaning1.57077040
26MP0004858_abnormal_nervous_system1.56793846
27MP0002733_abnormal_thermal_nociception1.55003462
28MP0005551_abnormal_eye_electrophysiolog1.51823369
29MP0002557_abnormal_social/conspecific_i1.51756494
30MP0001501_abnormal_sleep_pattern1.49817754
31MP0001970_abnormal_pain_threshold1.48783385
32MP0004215_abnormal_myocardial_fiber1.43756547
33MP0002882_abnormal_neuron_morphology1.43662153
34MP0004272_abnormal_basement_membrane1.41763185
35MP0004811_abnormal_neuron_physiology1.41413645
36MP0006276_abnormal_autonomic_nervous1.40696627
37MP0000569_abnormal_digit_pigmentation1.40696107
38MP0005275_abnormal_skin_tensile1.39669311
39MP0005386_behavior/neurological_phenoty1.38887748
40MP0004924_abnormal_behavior1.38887748
41MP0003937_abnormal_limbs/digits/tail_de1.37401180
42MP0003787_abnormal_imprinting1.37000461
43MP0003890_abnormal_embryonic-extraembry1.36448728
44MP0001984_abnormal_olfaction1.34439914
45MP0000920_abnormal_myelination1.33809788
46MP0004133_heterotaxia1.33110073
47MP0005171_absent_coat_pigmentation1.32644466
48MP0000955_abnormal_spinal_cord1.32263216
49MP0002837_dystrophic_cardiac_calcinosis1.31743842
50MP0004145_abnormal_muscle_electrophysio1.31662363
51MP0000383_abnormal_hair_follicle1.29739361
52MP0004085_abnormal_heartbeat1.29332957
53MP0008877_abnormal_DNA_methylation1.26799164
54MP0003941_abnormal_skin_development1.26406532
55MP0000566_synostosis1.25478821
56MP0010386_abnormal_urinary_bladder1.24694483
57MP0002234_abnormal_pharynx_morphology1.23987394
58MP0002822_catalepsy1.23914193
59MP0004885_abnormal_endolymph1.23383943
60MP0003755_abnormal_palate_morphology1.23298433
61MP0005645_abnormal_hypothalamus_physiol1.23174705
62MP0005248_abnormal_Harderian_gland1.22411830
63MP0000579_abnormal_nail_morphology1.22104573
64MP0000647_abnormal_sebaceous_gland1.21267514
65MP0001299_abnormal_eye_distance/1.20922055
66MP0000427_abnormal_hair_cycle1.20569008
67MP0005646_abnormal_pituitary_gland1.20039365
68MP0009384_cardiac_valve_regurgitation1.18929189
69MP0002066_abnormal_motor_capabilities/c1.18380568
70MP0010678_abnormal_skin_adnexa1.18004542
71MP0001879_abnormal_lymphatic_vessel1.17640316
72MP0001188_hyperpigmentation1.15605827
73MP0003329_amyloid_beta_deposits1.13954734
74MP0004742_abnormal_vestibular_system1.13638358
75MP0003634_abnormal_glial_cell1.13333912
76MP0001502_abnormal_circadian_rhythm1.13053691
77MP0005503_abnormal_tendon_morphology1.11530523
78MP0003137_abnormal_impulse_conducting1.11135048
79MP0003879_abnormal_hair_cell1.09737289
80MP0002233_abnormal_nose_morphology1.09719513
81MP0003045_fibrosis1.09514953
82MP0003950_abnormal_plasma_membrane1.09275686
83MP0002152_abnormal_brain_morphology1.09041334
84MP0005409_darkened_coat_color1.05912729
85MP0000537_abnormal_urethra_morphology1.05763305
86MP0003633_abnormal_nervous_system1.02691465
87MP0000049_abnormal_middle_ear1.01962110
88MP0009250_abnormal_appendicular_skeleto1.01954387
89MP0003631_nervous_system_phenotype1.01247421
90MP0001485_abnormal_pinna_reflex1.01023787
91MP0008438_abnormal_cutaneous_collagen0.99387450
92MP0002938_white_spotting0.99359714
93MP0004142_abnormal_muscle_tone0.98705603
94MP0005187_abnormal_penis_morphology0.97262013
95MP0004484_altered_response_of0.96518956
96MP0003935_abnormal_craniofacial_develop0.96177152
97MP0002229_neurodegeneration0.96130078
98MP0002752_abnormal_somatic_nervous0.95388874
99MP0003632_abnormal_nervous_system0.94252104
100MP0002751_abnormal_autonomic_nervous0.92296145
101MP0003136_yellow_coat_color0.91692448
102MP0005595_abnormal_vascular_smooth0.91440075
103MP0001177_atelectasis0.91149801
104MP0002909_abnormal_adrenal_gland0.91021685
105MP0003121_genomic_imprinting0.90009468
106MP0001958_emphysema0.89558135
107MP0001529_abnormal_vocalization0.87718051
108MP0003122_maternal_imprinting0.87689972
109MP0000534_abnormal_ureter_morphology0.86441019
110MP0004233_abnormal_muscle_weight0.85619655
111MP0006138_congestive_heart_failure0.84938752
112MP0005620_abnormal_muscle_contractility0.84571772
113MP0002896_abnormal_bone_mineralization0.84501521
114MP0003119_abnormal_digestive_system0.84076878
115MP0006072_abnormal_retinal_apoptosis0.83760287
116MP0001963_abnormal_hearing_physiology0.82429802
117MP0005253_abnormal_eye_physiology0.81982457
118MP0005391_vision/eye_phenotype0.81571841
119MP0002638_abnormal_pupillary_reflex0.81009922
120MP0009053_abnormal_anal_canal0.80611302
121MP0000432_abnormal_head_morphology0.79744578
122MP0000631_abnormal_neuroendocrine_gland0.79165723
123MP0003861_abnormal_nervous_system0.78898245
124MP0004036_abnormal_muscle_relaxation0.76881197
125MP0002108_abnormal_muscle_morphology0.75490484
126MP0000749_muscle_degeneration0.74404762
127MP0004084_abnormal_cardiac_muscle0.73781115
128MP0000747_muscle_weakness0.72367975
129MP0002102_abnormal_ear_morphology0.70294670
130MP0005394_taste/olfaction_phenotype0.69986492
131MP0005499_abnormal_olfactory_system0.69986492
132MP0002090_abnormal_vision0.68923250
133MP0002972_abnormal_cardiac_muscle0.68453409
134MP0001905_abnormal_dopamine_level0.67634109
135MP0001943_abnormal_respiration0.65599840
136MP0000013_abnormal_adipose_tissue0.65543952
137MP0005195_abnormal_posterior_eye0.65388055
138MP0002069_abnormal_eating/drinking_beha0.63852489
139MP0003690_abnormal_glial_cell0.63752140

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.48838105
2Ulnar claw (HP:0001178)4.95091874
3Action tremor (HP:0002345)4.74059868
4Termporal pattern (HP:0011008)4.58891312
5Insidious onset (HP:0003587)4.58891312
6Myokymia (HP:0002411)4.29640113
7Focal seizures (HP:0007359)4.22529237
8Epileptic encephalopathy (HP:0200134)3.72886708
9Progressive cerebellar ataxia (HP:0002073)3.29404478
10Segmental peripheral demyelination/remyelination (HP:0003481)3.25715589
11Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.23612524
12Febrile seizures (HP:0002373)3.21954341
13Atonic seizures (HP:0010819)3.12330464
14Hyperventilation (HP:0002883)3.09143935
15Broad-based gait (HP:0002136)2.98015669
16Onion bulb formation (HP:0003383)2.85236771
17Steppage gait (HP:0003376)2.80482433
18Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.77704491
19Hammertoe (HP:0001765)2.75930688
20Gaze-evoked nystagmus (HP:0000640)2.70818896
21Absence seizures (HP:0002121)2.63025965
22Dysdiadochokinesis (HP:0002075)2.60074661
23Drooling (HP:0002307)2.56237378
24Excessive salivation (HP:0003781)2.56237378
25Dialeptic seizures (HP:0011146)2.53738033
26Decreased motor nerve conduction velocity (HP:0003431)2.49247994
27Generalized tonic-clonic seizures (HP:0002069)2.48514470
28Dysmetria (HP:0001310)2.48298273
29Visual hallucinations (HP:0002367)2.41352016
30Truncal ataxia (HP:0002078)2.40795194
31Amblyopia (HP:0000646)2.39488419
32Peripheral hypomyelination (HP:0007182)2.38781601
33Overgrowth (HP:0001548)2.37513516
34Ankle clonus (HP:0011448)2.34732514
35Genetic anticipation (HP:0003743)2.33949159
36Impaired proprioception (HP:0010831)2.33200296
37Impaired vibration sensation in the lower limbs (HP:0002166)2.32526115
38Absent speech (HP:0001344)2.31694999
39Abnormality of midbrain morphology (HP:0002418)2.29606801
40Molar tooth sign on MRI (HP:0002419)2.29606801
41Urinary bladder sphincter dysfunction (HP:0002839)2.26861429
42Supranuclear gaze palsy (HP:0000605)2.21506040
43Nephronophthisis (HP:0000090)2.18903284
44Abnormality of the corticospinal tract (HP:0002492)2.18785447
45Foot dorsiflexor weakness (HP:0009027)2.17553903
46Degeneration of the lateral corticospinal tracts (HP:0002314)2.15291490
47Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.15291490
48Neurofibrillary tangles (HP:0002185)2.12330704
49Poor eye contact (HP:0000817)2.10803807
50Abnormality of the foot musculature (HP:0001436)2.08713263
51Scanning speech (HP:0002168)2.06676284
52Dynein arm defect of respiratory motile cilia (HP:0012255)2.06407642
53Absent/shortened dynein arms (HP:0200106)2.06407642
54Pancreatic fibrosis (HP:0100732)2.05983149
55Hemiparesis (HP:0001269)2.05174611
56Postural tremor (HP:0002174)2.04445252
57Prolonged QT interval (HP:0001657)2.04307507
58Pachygyria (HP:0001302)2.02894413
59Cutaneous finger syndactyly (HP:0010554)2.02807031
60Limb dystonia (HP:0002451)2.02574333
61Exotropia (HP:0000577)2.01395565
62Spastic gait (HP:0002064)2.01114682
63Abnormality of the ischium (HP:0003174)1.99583744
64Cerebral inclusion bodies (HP:0100314)1.98546353
65Epileptiform EEG discharges (HP:0011182)1.98389139
66Megalencephaly (HP:0001355)1.98293379
67Urinary urgency (HP:0000012)1.97758668
68Abnormality of the renal medulla (HP:0100957)1.97205597
69Abnormality of the lower motor neuron (HP:0002366)1.96667779
70Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.95232810
71Short 4th metacarpal (HP:0010044)1.95232810
72Lower limb muscle weakness (HP:0007340)1.94626817
73Primary atrial arrhythmia (HP:0001692)1.94565343
74Syncope (HP:0001279)1.91722572
75Atrial fibrillation (HP:0005110)1.91454953
76Volvulus (HP:0002580)1.90741322
77Abnormal social behavior (HP:0012433)1.90550300
78Impaired social interactions (HP:0000735)1.90550300
79Sudden death (HP:0001699)1.89572109
80Chorioretinal atrophy (HP:0000533)1.88877067
81Blue irides (HP:0000635)1.87917450
82Intention tremor (HP:0002080)1.87270241
83Bradycardia (HP:0001662)1.86750458
84True hermaphroditism (HP:0010459)1.85735734
85Coronal craniosynostosis (HP:0004440)1.85289151
86Abnormal EKG (HP:0003115)1.84667602
87Aplasia involving bones of the extremities (HP:0009825)1.84172188
88Aplasia involving bones of the upper limbs (HP:0009823)1.84172188
89Aplasia of the phalanges of the hand (HP:0009802)1.84172188
90EEG with generalized epileptiform discharges (HP:0011198)1.84008656
91Lissencephaly (HP:0001339)1.84008347
92Limited hip movement (HP:0008800)1.83810271
93Retinal dysplasia (HP:0007973)1.81435860
94Lower limb amyotrophy (HP:0007210)1.80818597
95Protruding tongue (HP:0010808)1.79257432
96Genital tract atresia (HP:0001827)1.79122655
97Postural instability (HP:0002172)1.79044130
98Impaired smooth pursuit (HP:0007772)1.78451055
99Medial flaring of the eyebrow (HP:0010747)1.77759310
100Thickened helices (HP:0000391)1.77559583
101Abnormality of salivation (HP:0100755)1.77430671
102Morphological abnormality of the middle ear (HP:0008609)1.77314079
103Chronic hepatic failure (HP:0100626)1.76528937
104Gait imbalance (HP:0002141)1.76492805
105Supraventricular arrhythmia (HP:0005115)1.73658614
106Supraventricular tachycardia (HP:0004755)1.72964810
107Hypsarrhythmia (HP:0002521)1.72923210
108Atrophic scars (HP:0001075)1.72914234
109Preaxial foot polydactyly (HP:0001841)1.72761507
110Optic nerve hypoplasia (HP:0000609)1.72063574
111Inability to walk (HP:0002540)1.71499380
112Upper limb muscle weakness (HP:0003484)1.71320918
113Hypoplastic labia majora (HP:0000059)1.71240821
114Tubular atrophy (HP:0000092)1.71128211
115Hypoplastic ischia (HP:0003175)1.70920348
116Depression (HP:0000716)1.70305313
117Difficulty running (HP:0009046)1.70008689
118Gait ataxia (HP:0002066)1.69304616
119Alacrima (HP:0000522)1.68726165
120Stereotypic behavior (HP:0000733)1.68380196
121Cutaneous syndactyly (HP:0012725)1.67055899
122Vaginal atresia (HP:0000148)1.65080080
123Vitreoretinal degeneration (HP:0000655)1.64681047
124Distal sensory impairment (HP:0002936)1.64573288
125Abnormality of the calf musculature (HP:0001430)1.64418203
126Pancreatic cysts (HP:0001737)1.62145479
127Hemiplegia (HP:0002301)1.62122544
128Abnormal eating behavior (HP:0100738)1.62088960
129Dysmetric saccades (HP:0000641)1.61889496
130Pheochromocytoma (HP:0002666)1.61375230
131Severe Myopia (HP:0011003)1.61260913
132Fair hair (HP:0002286)1.60974407
133Large earlobe (HP:0009748)1.60320430
134Ventricular fibrillation (HP:0001663)1.60023068
135Impaired vibratory sensation (HP:0002495)1.59960921
136Abnormality of the labia minora (HP:0012880)1.59880642
137Widely spaced teeth (HP:0000687)1.59657712
138Increased CSF protein (HP:0002922)1.59567969
139Keratoconus (HP:0000563)1.55986556
140Increased corneal curvature (HP:0100692)1.55986556
141Shawl scrotum (HP:0000049)1.55824515
142Aplasia/Hypoplasia of the tibia (HP:0005772)1.55475094
143Astrocytoma (HP:0009592)1.54643805
144Abnormality of the astrocytes (HP:0100707)1.54643805
145Labial hypoplasia (HP:0000066)1.53663705
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.52796912
147Abnormality of the labia majora (HP:0012881)1.52009450
148Papillary thyroid carcinoma (HP:0002895)1.50750942
149Type II lissencephaly (HP:0007260)1.50006013
150Hip contracture (HP:0003273)1.49896703
151Hepatoblastoma (HP:0002884)1.49775418
152Broad metatarsal (HP:0001783)1.48355606
153Postaxial hand polydactyly (HP:0001162)1.47791356
154Short foot (HP:0001773)1.47788643
155Esotropia (HP:0000565)1.46906836
156Small hand (HP:0200055)1.46679950
157Narrow forehead (HP:0000341)1.46376621
158Delayed gross motor development (HP:0002194)1.45840794
159Absent frontal sinuses (HP:0002688)1.43908555
160Inappropriate behavior (HP:0000719)1.41634452
161Tented upper lip vermilion (HP:0010804)1.40243861
162Adactyly (HP:0009776)1.40224635
163Congenital primary aphakia (HP:0007707)1.39834982
164Gastrointestinal atresia (HP:0002589)1.39601919
165Midline defect of the nose (HP:0004122)1.39494906
166Congenital stationary night blindness (HP:0007642)1.39482498
167Cortical dysplasia (HP:0002539)1.39153629
168Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.39081441
169Calf muscle hypertrophy (HP:0008981)1.38664409

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.06672826
2EPHA43.61288011
3FRK3.27909964
4MARK12.87653769
5MAP3K42.79018275
6CASK2.63289486
7MAP3K92.43636948
8PRKD32.29123906
9NTRK22.12910088
10MAP2K71.92647508
11DAPK21.91176617
12PAK61.84157559
13MINK11.74482352
14MET1.61492084
15PNCK1.60339159
16STK38L1.59874366
17STK391.53596268
18MAPK131.53278362
19KSR11.52412661
20NTRK11.42716097
21MAP2K41.39713373
22TNIK1.38687459
23CDK51.38253136
24DMPK1.34738932
25UHMK11.34678580
26FGFR21.32955334
27PLK21.31036846
28SGK4941.28575221
29SGK2231.28575221
30PHKG11.27319801
31PHKG21.27319801
32BCR1.24339344
33SIK21.24304935
34BMPR1B1.21022906
35PAK31.19398229
36PTK2B1.18639599
37MAP3K21.18225332
38TYRO31.16439684
39OXSR11.16354830
40KSR21.15657441
41CAMK2A1.15137804
42MAP4K21.09859285
43CAMK2B1.08230772
44MKNK21.08098372
45MARK21.06393912
46CAMK1G1.04324441
47FER1.03036149
48PRPF4B1.02756841
49DYRK21.02362866
50SGK21.01829134
51EPHB21.01445666
52STK30.99295645
53WNK10.99089795
54MST1R0.96517946
55RET0.94520215
56PTK20.92769328
57PRKCG0.90505004
58STK380.89384863
59CAMK1D0.88923353
60PKN10.88472046
61ADRBK20.88468074
62SIK30.87914695
63PRKCE0.87470905
64ICK0.86873400
65CSNK1G10.86753934
66GRK50.86448906
67ERBB40.86084311
68TIE10.82775754
69GRK10.82669074
70CAMK2D0.82632956
71STK110.82480965
72CSNK1G20.82269538
73WNK40.81209524
74SGK30.79512891
75CAMKK10.78969048
76SGK10.78089242
77MYLK0.78017368
78PDGFRB0.76718826
79CDK180.75754909
80OBSCN0.75739731
81CDC42BPA0.75146961
82DAPK10.74007096
83CDK150.71722391
84CDK140.69634043
85AKT30.69440266
86DYRK1A0.69242029
87LIMK10.69059546
88RIPK40.69000466
89LATS20.68668819
90DYRK30.68489578
91CSNK1G30.67242289
92LMTK20.64990395
93TGFBR10.64935776
94ACVR1B0.64333956
95FGR0.63018314
96CAMK10.62341806
97BMPR20.60890043
98ROCK20.60825982
99PDGFRA0.59526351
100DDR20.58979551
101GRK70.58437035
102GSK3A0.58320623
103CDK11A0.57953239
104PRKCH0.57774385
105CDK190.56840109
106ROCK10.56611894
107CAMK40.56317520
108CAMK2G0.55715131
109LATS10.54342229
110MUSK0.53609862
111PRKCZ0.50988724
112INSRR0.49759833
113MAPK100.49671729
114WEE10.49409935
115EPHA30.49348417
116PRKD10.49080085
117RPS6KA30.48813268
118MAPK150.47983535
119CSNK1A1L0.47897304
120CDK30.45869458
121PDPK10.44969652
122PINK10.44600246
123ERBB30.43754484
124MAP3K120.43592726
125PRKG10.42494151
126BRD40.42071593
127WNK30.41518666
128CAMKK20.41412142
129FES0.40756717
130STK240.40450211
131FGFR10.40136901
132MAPKAPK50.40127715
133CSNK1E0.39663678
134TRIM280.39410401
135MKNK10.39343854
136TGFBR20.38779617
137PRKAA10.38622895

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.08871959
2Circadian entrainment_Homo sapiens_hsa047132.53377391
3Glutamatergic synapse_Homo sapiens_hsa047242.44636935
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.39343015
5Olfactory transduction_Homo sapiens_hsa047402.29856317
6GABAergic synapse_Homo sapiens_hsa047272.27968054
7Long-term potentiation_Homo sapiens_hsa047202.25410008
8Synaptic vesicle cycle_Homo sapiens_hsa047212.21329687
9Morphine addiction_Homo sapiens_hsa050322.17294314
10Phototransduction_Homo sapiens_hsa047442.14738810
11Amphetamine addiction_Homo sapiens_hsa050312.11686869
12Dopaminergic synapse_Homo sapiens_hsa047281.91087313
13Salivary secretion_Homo sapiens_hsa049701.85641465
14Renin secretion_Homo sapiens_hsa049241.80967494
15Insulin secretion_Homo sapiens_hsa049111.78988025
16Axon guidance_Homo sapiens_hsa043601.75283208
17Cholinergic synapse_Homo sapiens_hsa047251.72155382
18Taste transduction_Homo sapiens_hsa047421.70752550
19Serotonergic synapse_Homo sapiens_hsa047261.67553862
20Gastric acid secretion_Homo sapiens_hsa049711.64545359
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62898726
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62450209
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59328871
24Oxytocin signaling pathway_Homo sapiens_hsa049211.58650707
25Long-term depression_Homo sapiens_hsa047301.53506275
26Calcium signaling pathway_Homo sapiens_hsa040201.50830936
27Dilated cardiomyopathy_Homo sapiens_hsa054141.49469110
28Cocaine addiction_Homo sapiens_hsa050301.43732270
29GnRH signaling pathway_Homo sapiens_hsa049121.36823791
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34697791
31Dorso-ventral axis formation_Homo sapiens_hsa043201.33832257
32cAMP signaling pathway_Homo sapiens_hsa040241.33799669
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31861583
34Gap junction_Homo sapiens_hsa045401.31336664
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24862275
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.22900190
37Type II diabetes mellitus_Homo sapiens_hsa049301.17785753
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17659828
39ErbB signaling pathway_Homo sapiens_hsa040121.16889887
40Steroid biosynthesis_Homo sapiens_hsa001001.13574622
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.12779345
42Melanogenesis_Homo sapiens_hsa049161.12768515
43Glioma_Homo sapiens_hsa052141.12516025
44Estrogen signaling pathway_Homo sapiens_hsa049151.12481780
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11060377
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10637048
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10086272
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09753508
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.09078972
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06343404
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03500687
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02608407
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96454914
54Cardiac muscle contraction_Homo sapiens_hsa042600.96419305
55TGF-beta signaling pathway_Homo sapiens_hsa043500.93670297
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91971143
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89446329
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88501745
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.86984103
60Nitrogen metabolism_Homo sapiens_hsa009100.85671192
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84780820
62Choline metabolism in cancer_Homo sapiens_hsa052310.82991408
63Selenocompound metabolism_Homo sapiens_hsa004500.81272329
64MAPK signaling pathway_Homo sapiens_hsa040100.79557315
65Rap1 signaling pathway_Homo sapiens_hsa040150.79181021
66* Ras signaling pathway_Homo sapiens_hsa040140.79159284
67Protein digestion and absorption_Homo sapiens_hsa049740.77435765
68Tight junction_Homo sapiens_hsa045300.76781038
69Pancreatic secretion_Homo sapiens_hsa049720.76447005
70Wnt signaling pathway_Homo sapiens_hsa043100.73623635
71Renal cell carcinoma_Homo sapiens_hsa052110.72836196
72Collecting duct acid secretion_Homo sapiens_hsa049660.71557481
73Linoleic acid metabolism_Homo sapiens_hsa005910.67303757
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65157810
75Ovarian steroidogenesis_Homo sapiens_hsa049130.65031088
76Oocyte meiosis_Homo sapiens_hsa041140.63406197
77Glucagon signaling pathway_Homo sapiens_hsa049220.63359067
78Focal adhesion_Homo sapiens_hsa045100.62077627
79ECM-receptor interaction_Homo sapiens_hsa045120.61284870
80MicroRNAs in cancer_Homo sapiens_hsa052060.60820154
81Thyroid hormone synthesis_Homo sapiens_hsa049180.60658524
82Circadian rhythm_Homo sapiens_hsa047100.60507804
83Hedgehog signaling pathway_Homo sapiens_hsa043400.60456224
84VEGF signaling pathway_Homo sapiens_hsa043700.59898998
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57720572
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55912776
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55743133
88Alcoholism_Homo sapiens_hsa050340.54988434
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54770941
90Adherens junction_Homo sapiens_hsa045200.54767615
91Vibrio cholerae infection_Homo sapiens_hsa051100.52419386
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.52293803
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51755634
94Inositol phosphate metabolism_Homo sapiens_hsa005620.51492545
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50539633
96Butanoate metabolism_Homo sapiens_hsa006500.49997500
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.49345807
98Pathways in cancer_Homo sapiens_hsa052000.49329730
99Sphingolipid metabolism_Homo sapiens_hsa006000.48839061
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48312714
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47009896
102mTOR signaling pathway_Homo sapiens_hsa041500.46919079
103Endometrial cancer_Homo sapiens_hsa052130.46730272
104Hippo signaling pathway_Homo sapiens_hsa043900.45926501
105Endocytosis_Homo sapiens_hsa041440.45773679
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45623720
107Histidine metabolism_Homo sapiens_hsa003400.45372581
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.45352559
109Propanoate metabolism_Homo sapiens_hsa006400.45242639
110Fatty acid biosynthesis_Homo sapiens_hsa000610.44869685
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44041828
112Bile secretion_Homo sapiens_hsa049760.43788151
113Melanoma_Homo sapiens_hsa052180.41943263
114Insulin signaling pathway_Homo sapiens_hsa049100.40944990
115Tryptophan metabolism_Homo sapiens_hsa003800.40713793
116Ether lipid metabolism_Homo sapiens_hsa005650.40226335
117Proteoglycans in cancer_Homo sapiens_hsa052050.38379384
118Amoebiasis_Homo sapiens_hsa051460.38090733
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36938014
120Basal cell carcinoma_Homo sapiens_hsa052170.33087887
121African trypanosomiasis_Homo sapiens_hsa051430.31665823
122Prion diseases_Homo sapiens_hsa050200.30795996

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