RASD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)6.80179940
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.65109103
3retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.28418682
4endocrine pancreas development (GO:0031018)6.15582678
5regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022356.13832227
6regulation of type B pancreatic cell apoptotic process (GO:2000674)6.06845806
7peptide hormone processing (GO:0016486)5.94036253
8COPII vesicle coating (GO:0048208)5.82186436
9protein retention in ER lumen (GO:0006621)5.78266714
10signal peptide processing (GO:0006465)5.47684473
11negative regulation of glycoprotein biosynthetic process (GO:0010561)4.70604970
12positive regulation of insulin secretion (GO:0032024)4.70585244
13sequestering of metal ion (GO:0051238)4.68052846
14glandular epithelial cell differentiation (GO:0002067)4.67980170
15insulin secretion (GO:0030073)4.61116300
16exocrine pancreas development (GO:0031017)4.58908829
17vesicle coating (GO:0006901)4.55708339
18glutamate secretion (GO:0014047)4.43137518
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.39274541
20response to dietary excess (GO:0002021)4.35892353
21synaptic vesicle maturation (GO:0016188)4.28789339
22synaptic vesicle exocytosis (GO:0016079)4.25064251
23regulation of insulin secretion (GO:0050796)4.24686726
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.22127716
25activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.02267178
26regulation of oxidative phosphorylation (GO:0002082)3.88925977
27regulation of peptide hormone secretion (GO:0090276)3.86697961
28positive regulation of peptide hormone secretion (GO:0090277)3.83853336
29regulation of peptide secretion (GO:0002791)3.82101583
30negative regulation of insulin secretion (GO:0046676)3.81897995
31ER overload response (GO:0006983)3.79799013
32positive regulation of nuclease activity (GO:0032075)3.77937698
33positive regulation of peptide secretion (GO:0002793)3.74656941
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.72085340
35toxin metabolic process (GO:0009404)3.69692040
36ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.68854013
37negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.68539145
38cellular potassium ion homeostasis (GO:0030007)3.61688294
39peptide hormone secretion (GO:0030072)3.57832610
40macroautophagy (GO:0016236)3.56012214
41negative regulation of glycoprotein metabolic process (GO:1903019)3.55971522
42detection of calcium ion (GO:0005513)3.52171580
43positive regulation of glycolytic process (GO:0045821)3.49660100
44cerebellar granule cell differentiation (GO:0021707)3.48872798
45peptide secretion (GO:0002790)3.48622863
46neurotransmitter secretion (GO:0007269)3.46426300
47regulation of nuclease activity (GO:0032069)3.45523520
48negative regulation of peptide hormone secretion (GO:0090278)3.44538394
49regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.42831599
50regulation of hormone secretion (GO:0046883)3.40181209
51negative regulation of peptide secretion (GO:0002792)3.38558057
52cellular zinc ion homeostasis (GO:0006882)3.37326150
53sodium ion export (GO:0071436)3.37042668
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35719442
55cellular response to topologically incorrect protein (GO:0035967)3.33780175
56endoplasmic reticulum unfolded protein response (GO:0030968)3.33549451
57fatty acid homeostasis (GO:0055089)3.33008758
58intra-Golgi vesicle-mediated transport (GO:0006891)3.30117310
59protein localization to Golgi apparatus (GO:0034067)3.27312504
60cellular response to unfolded protein (GO:0034620)3.25982550
61ER to Golgi vesicle-mediated transport (GO:0006888)3.24397811
62response to misfolded protein (GO:0051788)3.23132798
63* nitric oxide mediated signal transduction (GO:0007263)3.21859951
64regulation of short-term neuronal synaptic plasticity (GO:0048172)3.19842956
65negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.19459519
66tricarboxylic acid metabolic process (GO:0072350)3.18160104
67response to hexose (GO:0009746)3.17755308
68regulation of peptide transport (GO:0090087)3.15718351
69nucleoside diphosphate catabolic process (GO:0009134)3.15318564
70positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.14521826
71ER-nucleus signaling pathway (GO:0006984)3.12377076
72GDP-mannose metabolic process (GO:0019673)3.11727448
73response to glucose (GO:0009749)3.11603873
74positive regulation of hormone secretion (GO:0046887)3.11241653
75metanephric nephron tubule development (GO:0072234)3.10198487
76metanephric tubule development (GO:0072170)3.10198487
77response to monosaccharide (GO:0034284)3.10126794
78metanephric nephron epithelium development (GO:0072243)3.08814494
79axon ensheathment in central nervous system (GO:0032291)3.06716374
80central nervous system myelination (GO:0022010)3.06716374
81dendritic spine morphogenesis (GO:0060997)3.05455567
82hormone secretion (GO:0046879)3.04272989
83low-density lipoprotein particle clearance (GO:0034383)3.02537669
84nephron tubule formation (GO:0072079)2.98737333
85regulation of neuronal synaptic plasticity (GO:0048168)2.97656660
86regulation of synaptic vesicle exocytosis (GO:2000300)2.93971532
87potassium ion homeostasis (GO:0055075)2.93670449
88protein N-linked glycosylation via asparagine (GO:0018279)2.93664029
89cellular response to glucagon stimulus (GO:0071377)2.93069618
90cellular response to vitamin D (GO:0071305)2.91934714
91regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.91905480
92cellular response to cadmium ion (GO:0071276)2.91665376
93regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.91147836
94peptidyl-asparagine modification (GO:0018196)2.90531892
95epithelial cell fate commitment (GO:0072148)2.89481820
96growth hormone secretion (GO:0030252)2.88320106
97glucose homeostasis (GO:0042593)2.87466014
98carbohydrate homeostasis (GO:0033500)2.87466014
99regulation of long-term neuronal synaptic plasticity (GO:0048169)2.87191767
100peptide transport (GO:0015833)2.85429043
101regulation of autophagic vacuole assembly (GO:2000785)2.85345085
102hormone transport (GO:0009914)2.84876891
103neuromuscular process controlling posture (GO:0050884)2.82726518
104triglyceride catabolic process (GO:0019433)2.82493355
105response to endoplasmic reticulum stress (GO:0034976)2.82337723
106regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.81962435
107neuronal ion channel clustering (GO:0045161)2.81666421
108metanephric epithelium development (GO:0072207)2.80261271
109cellular response to monosaccharide stimulus (GO:0071326)2.78874986
110cell communication by electrical coupling (GO:0010644)2.77036231
111positive regulation of synapse maturation (GO:0090129)2.76025444
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75246571
113cellular response to hexose stimulus (GO:0071331)2.74557850
114acylglycerol catabolic process (GO:0046464)2.71423915
115neutral lipid catabolic process (GO:0046461)2.71423915
116regulation of neurotransmitter levels (GO:0001505)2.70603943
117cGMP-mediated signaling (GO:0019934)2.70515676
118negative regulation of calcium ion transport into cytosol (GO:0010523)2.70358388
119adaptation of signaling pathway (GO:0023058)2.69861335
120positive regulation of p38MAPK cascade (GO:1900745)2.68677765
121neurotransmitter transport (GO:0006836)2.67828833
122potassium ion import (GO:0010107)2.67704501
123protein N-linked glycosylation (GO:0006487)2.67034266
124glandular epithelial cell development (GO:0002068)2.66613705
125calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.66384845
126negative regulation of metanephros development (GO:0072217)2.65717550
127regulation of synaptic vesicle transport (GO:1902803)2.65147848
128positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.64368029
129regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.64099894
130regulation of energy homeostasis (GO:2000505)2.63002993
131Golgi vesicle transport (GO:0048193)2.62994496
132peptide metabolic process (GO:0006518)2.62828360
133response to carbohydrate (GO:0009743)2.61454890
134ovulation from ovarian follicle (GO:0001542)2.61180967
135response to topologically incorrect protein (GO:0035966)2.59320535
136vocalization behavior (GO:0071625)2.57997862
137positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.56991493
138positive regulation of vesicle fusion (GO:0031340)2.55621935
139response to unfolded protein (GO:0006986)2.55453125
140postsynaptic membrane organization (GO:0001941)2.55261579
141response to redox state (GO:0051775)2.54803369
142positive regulation of metanephros development (GO:0072216)2.54683105
143eating behavior (GO:0042755)2.54490141
144L-amino acid import (GO:0043092)2.54177216
145regulation of p38MAPK cascade (GO:1900744)2.53978443
146cellular response to vitamin (GO:0071295)2.53785301
147positive regulation of neurotransmitter transport (GO:0051590)2.53170203
148regulation of synapse maturation (GO:0090128)2.52664831
149type B pancreatic cell development (GO:0003323)2.52017876
150cardiac conduction (GO:0061337)2.51615321
151cellular copper ion homeostasis (GO:0006878)2.51576438
152calcium-mediated signaling using intracellular calcium source (GO:0035584)2.51339465
153misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.50529961
154glycerolipid catabolic process (GO:0046503)2.49992253
155positive regulation of membrane potential (GO:0045838)2.48707003
156energy reserve metabolic process (GO:0006112)2.48599407
157cellular sodium ion homeostasis (GO:0006883)2.48511245
158locomotory exploration behavior (GO:0035641)2.48287259
159negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46904296
160regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.46460825
161maintenance of protein localization in organelle (GO:0072595)2.45335661
162myelin maintenance (GO:0043217)2.44841401
163neuronal action potential propagation (GO:0019227)2.44840752
164regulation of female receptivity (GO:0045924)2.43754315
165cell communication involved in cardiac conduction (GO:0086065)2.41795078
166regulation of neurotransmitter transport (GO:0051588)2.41155802
167regulation of respiratory system process (GO:0044065)2.40722064
168regulation of synapse structural plasticity (GO:0051823)2.39941971
169regulation of sequestering of triglyceride (GO:0010889)2.38059151
170regulation of neurotransmitter uptake (GO:0051580)2.35663767
171regulation of lipoprotein metabolic process (GO:0050746)2.35198313
172regulation of neurotransmitter secretion (GO:0046928)2.34880364
173positive regulation of neurotransmitter secretion (GO:0001956)2.34206234
174dendritic spine organization (GO:0097061)2.33907810
175regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.30208380
176long term synaptic depression (GO:0060292)2.29897572
177negative regulation of synaptic transmission, GABAergic (GO:0032229)2.27226679
178cellular response to gonadotropin stimulus (GO:0071371)2.25685932
179regulation of vesicle fusion (GO:0031338)2.25093406
180response to leptin (GO:0044321)2.24771489
181regulation of synaptic plasticity (GO:0048167)2.24296243
182regulation of glutamate receptor signaling pathway (GO:1900449)2.23722102
183ionotropic glutamate receptor signaling pathway (GO:0035235)2.23539892
184activation of protein kinase A activity (GO:0034199)2.22548212
185neuron projection regeneration (GO:0031102)2.20825379
186signal release (GO:0023061)2.20721779
187regulation of heart rate by cardiac conduction (GO:0086091)2.20612735
188iron coordination entity transport (GO:1901678)2.20205471
189cyclic-nucleotide-mediated signaling (GO:0019935)2.19884362
190nephron tubule development (GO:0072080)2.18792587
191membrane hyperpolarization (GO:0060081)2.17217089
192regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.17204968
193exploration behavior (GO:0035640)2.16045587
194regulation of ARF protein signal transduction (GO:0032012)2.14679707
195cAMP-mediated signaling (GO:0019933)2.14278923
196regulation of calcium ion-dependent exocytosis (GO:0017158)2.13348980
197COPI coating of Golgi vesicle (GO:0048205)10.2755317
198Golgi transport vesicle coating (GO:0048200)10.2755317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.94540962
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.62339061
3PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.58213164
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.07358061
5* CLOCK_20551151_ChIP-Seq_293T_Human2.83030006
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.63035078
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.52928965
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31528765
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31528765
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.28149519
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.19020337
12* EED_16625203_ChIP-ChIP_MESCs_Mouse2.17125095
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16687971
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14560115
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11826824
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.05483837
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01652866
18GATA1_22025678_ChIP-Seq_K562_Human1.98489147
19NR3C1_23031785_ChIP-Seq_PC12_Mouse1.96777570
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.90396485
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.81866410
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.77069490
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67006374
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64536445
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.61662198
26VDR_22108803_ChIP-Seq_LS180_Human1.59374733
27* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58514414
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56933912
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.56778660
30KDM2B_26808549_Chip-Seq_K562_Human1.54757109
31SOX2_27498859_Chip-Seq_STOMACH_Mouse1.54554316
32EZH2_22144423_ChIP-Seq_EOC_Human1.53105357
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50811055
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49078014
35* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.47933020
36DROSHA_22980978_ChIP-Seq_HELA_Human1.46478615
37GATA1_19941826_ChIP-Seq_K562_Human1.45703035
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.44899937
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44750543
40RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38921296
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.37716135
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37579036
43FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.34883237
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34542505
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33018276
46REST_21632747_ChIP-Seq_MESCs_Mouse1.31297547
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30939110
48* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30580784
49RXR_22158963_ChIP-Seq_LIVER_Mouse1.30330630
50BCAT_22108803_ChIP-Seq_LS180_Human1.29086713
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28171799
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28071284
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25434081
54ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25283862
55RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24830336
56REST_19997604_ChIP-ChIP_NEURONS_Mouse1.22384776
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22060336
58EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22028528
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22013683
60LXR_22292898_ChIP-Seq_THP-1_Human1.21923226
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21341889
62LXR_22158963_ChIP-Seq_LIVER_Mouse1.19956613
63TP53_20018659_ChIP-ChIP_R1E_Mouse1.19023894
64* EZH2_27294783_Chip-Seq_ESCs_Mouse1.17940752
65* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17894336
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17502231
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.17333746
68FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15643948
69* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12872488
70* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.12461595
71FOXA1_25552417_ChIP-Seq_VCAP_Human1.10334367
72SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09671421
73SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09321131
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.08621062
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07996302
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.06463575
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06406661
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06346410
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06285757
80* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06136628
81P68_20966046_ChIP-Seq_HELA_Human1.05729954
82PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05712898
83CREB1_26743006_Chip-Seq_LNCaP_Human1.05610797
84CDX2_20551321_ChIP-Seq_CACO-2_Human1.05473838
85* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05011644
86SOX2_20726797_ChIP-Seq_SW620_Human1.04948920
87TBX20_22080862_ChIP-Seq_HEART_Mouse1.04497768
88TBX20_22328084_ChIP-Seq_HEART_Mouse1.04497768
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03626806
90ZNF274_21170338_ChIP-Seq_K562_Hela1.03537019
91RACK7_27058665_Chip-Seq_MCF-7_Human1.02209187
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99988639
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99450711
94RARB_27405468_Chip-Seq_BRAIN_Mouse0.97007702
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95955000
96GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95611326
97* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95288489
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94741224
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94026936
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93455721
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93078959
102EP300_21415370_ChIP-Seq_HL-1_Mouse0.92662959
103CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90834515
104GATA2_21666600_ChIP-Seq_HMVEC_Human0.90513872
105EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90364504
106ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89714376
107KDM2B_26808549_Chip-Seq_DND41_Human0.89155174
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89054150
109ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88926529
110JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.88204102
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88033014
112* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87507288
113NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87414052
114CTCF_27219007_Chip-Seq_Bcells_Human0.86976450
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86766329
116ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86282400
117HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85912889
118AR_20517297_ChIP-Seq_VCAP_Human0.85400830
119TP63_17297297_ChIP-ChIP_HaCaT_Human0.85049978
120* RUNX1_27514584_Chip-Seq_MCF-7_Human0.84980176
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84877904
122* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.84279128
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83076696
124OCT4_19829295_ChIP-Seq_ESCs_Human0.82781764
125PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82527460
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81644503
127BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79824058
128SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79544770
129* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79513161
130CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79376949
131THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79098741
132CTCF_20526341_ChIP-Seq_ESCs_Human0.78711351
133ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78373141
134TET1_21490601_ChIP-Seq_MESCs_Mouse0.78155775
135DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77553203
136CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77182821
137* SMC4_20622854_ChIP-Seq_HELA_Human0.77008290
138TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76981569
139* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.76443790
140GATA3_24758297_ChIP-Seq_MCF-7_Human0.76229758
141MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.75028626
142FLI1_21867929_ChIP-Seq_TH2_Mouse0.73035965
143FOXH1_21741376_ChIP-Seq_ESCs_Human0.72816101
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.71057875
145TET1_21451524_ChIP-Seq_MESCs_Mouse0.70427340
146TP63_22573176_ChIP-Seq_HFKS_Human0.70367553
147MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.70134372

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue5.37024512
2MP0003283_abnormal_digestive_organ4.82950702
3MP0004043_abnormal_pH_regulation4.18291218
4MP0009780_abnormal_chondrocyte_physiolo3.68923574
5MP0010386_abnormal_urinary_bladder3.66732107
6MP0002909_abnormal_adrenal_gland3.61357315
7MP0002837_dystrophic_cardiac_calcinosis3.59305430
8MP0002877_abnormal_melanocyte_morpholog3.58630940
9MP0003195_calcinosis3.40093230
10MP0002693_abnormal_pancreas_physiology3.36129715
11MP0001944_abnormal_pancreas_morphology3.27818406
12MP0005379_endocrine/exocrine_gland_phen3.18423171
13MP0000003_abnormal_adipose_tissue3.05131663
14MP0005220_abnormal_exocrine_pancreas2.76593721
15MP0002064_seizures2.63949967
16MP0003880_abnormal_central_pattern2.62198363
17MP0000678_abnormal_parathyroid_gland2.59646940
18MP0003183_abnormal_peptide_metabolism2.55500404
19MP0005423_abnormal_somatic_nervous2.55443177
20MP0005645_abnormal_hypothalamus_physiol2.42348860
21MP0009745_abnormal_behavioral_response2.36084499
22MP0003635_abnormal_synaptic_transmissio2.34522095
23MP0003011_delayed_dark_adaptation2.25142052
24MP0002078_abnormal_glucose_homeostasis2.24577803
25MP0002876_abnormal_thyroid_physiology2.23047196
26MP0009046_muscle_twitch2.19828853
27MP0006072_abnormal_retinal_apoptosis2.14322811
28MP0002272_abnormal_nervous_system2.13652601
29MP0005670_abnormal_white_adipose2.00735664
30MP0005646_abnormal_pituitary_gland1.99859644
31MP0003300_gastrointestinal_ulcer1.88032792
32MP0002063_abnormal_learning/memory/cond1.83095412
33MP0004019_abnormal_vitamin_homeostasis1.80107158
34MP0003122_maternal_imprinting1.77333708
35MP0006054_spinal_hemorrhage1.76459357
36MP0003690_abnormal_glial_cell1.76170056
37MP0001765_abnormal_ion_homeostasis1.76012218
38MP0005375_adipose_tissue_phenotype1.73525456
39MP0002572_abnormal_emotion/affect_behav1.68799165
40MP0000462_abnormal_digestive_system1.66418500
41MP0009643_abnormal_urine_homeostasis1.61530501
42MP0003724_increased_susceptibility_to1.58392546
43MP0004264_abnormal_extraembryonic_tissu1.56820399
44MP0008569_lethality_at_weaning1.56722611
45MP0001756_abnormal_urination1.54951057
46MP0002928_abnormal_bile_duct1.51007772
47MP0008961_abnormal_basal_metabolism1.48878301
48MP0001968_abnormal_touch/_nociception1.47235499
49MP0002163_abnormal_gland_morphology1.46978896
50MP0001486_abnormal_startle_reflex1.46832445
51MP0003959_abnormal_lean_body1.46805941
52MP0005535_abnormal_body_temperature1.44824413
53MP0003953_abnormal_hormone_level1.41598680
54MP0002638_abnormal_pupillary_reflex1.37351426
55MP0001661_extended_life_span1.37059205
56MP0004510_myositis1.35346747
57MP0002557_abnormal_social/conspecific_i1.34389153
58MP0001440_abnormal_grooming_behavior1.34246525
59MP0004130_abnormal_muscle_cell1.30005467
60MP0000230_abnormal_systemic_arterial1.29724888
61MP0005058_abnormal_lysosome_morphology1.25500160
62MP0002896_abnormal_bone_mineralization1.25023147
63MP0001905_abnormal_dopamine_level1.24600535
64MP0005448_abnormal_energy_balance1.21790875
65MP0003631_nervous_system_phenotype1.19992209
66MP0002138_abnormal_hepatobiliary_system1.18787277
67MP0004270_analgesia1.18513901
68MP0004133_heterotaxia1.16750909
69MP0004272_abnormal_basement_membrane1.12699158
70MP0009840_abnormal_foam_cell1.11683822
71MP0005636_abnormal_mineral_homeostasis1.10862296
72MP0002971_abnormal_brown_adipose1.08683896
73MP0000613_abnormal_salivary_gland1.07522825
74MP0003075_altered_response_to1.06695330
75MP0001879_abnormal_lymphatic_vessel1.02091898
76MP0005334_abnormal_fat_pad1.01339957
77MP0001501_abnormal_sleep_pattern1.00400755
78MP0002118_abnormal_lipid_homeostasis0.98529157
79MP0005503_abnormal_tendon_morphology0.97761223
80MP0000920_abnormal_myelination0.97170341
81MP0003172_abnormal_lysosome_physiology0.96436172
82MP0005310_abnormal_salivary_gland0.96428107
83MP0002067_abnormal_sensory_capabilities0.94427042
84MP0005551_abnormal_eye_electrophysiolog0.94083996
85MP0004858_abnormal_nervous_system0.93694275
86MP0008872_abnormal_physiological_respon0.92959790
87MP0010368_abnormal_lymphatic_system0.91609125
88MP0005409_darkened_coat_color0.91519058
89MP0002970_abnormal_white_adipose0.91176729
90MP0003634_abnormal_glial_cell0.89900764
91MP0004924_abnormal_behavior0.89876435
92MP0005386_behavior/neurological_phenoty0.89876435
93MP0003879_abnormal_hair_cell0.89427726
94MP0002736_abnormal_nociception_after0.87998929
95MP0005452_abnormal_adipose_tissue0.87617170
96MP0002066_abnormal_motor_capabilities/c0.85202309
97MP0002139_abnormal_hepatobiliary_system0.85164360
98MP0002735_abnormal_chemical_nociception0.85113635
99MP0002822_catalepsy0.85015772
100MP0005167_abnormal_blood-brain_barrier0.82383403
101MP0000751_myopathy0.81548584
102MP0000639_abnormal_adrenal_gland0.81474543
103MP0002229_neurodegeneration0.79446738
104MP0004185_abnormal_adipocyte_glucose0.79104545
105* MP0001502_abnormal_circadian_rhythm0.79022177
106MP0001986_abnormal_taste_sensitivity0.78929279
107MP0004885_abnormal_endolymph0.78198424
108MP0000604_amyloidosis0.77567787
109MP0005666_abnormal_adipose_tissue0.76441292
110MP0006138_congestive_heart_failure0.76163688
111MP0005084_abnormal_gallbladder_morpholo0.74397551
112MP0001963_abnormal_hearing_physiology0.74279145
113MP0008875_abnormal_xenobiotic_pharmacok0.73456373
114MP0006036_abnormal_mitochondrial_physio0.71830679
115MP0001851_eye_inflammation0.71807880
116MP0005584_abnormal_enzyme/coenzyme_acti0.71657739
117MP0002882_abnormal_neuron_morphology0.71511622
118MP0002733_abnormal_thermal_nociception0.71318875
119MP0002249_abnormal_larynx_morphology0.71100888
120MP0000681_abnormal_thyroid_gland0.70252308
121MP0001664_abnormal_digestion0.67630701
122MP0003787_abnormal_imprinting0.67361344
123MP0002734_abnormal_mechanical_nocicepti0.64927009
124MP0005365_abnormal_bile_salt0.62423533
125MP0002234_abnormal_pharynx_morphology0.62387893
126MP0003119_abnormal_digestive_system0.60442313
127MP0005253_abnormal_eye_physiology0.59963052
128MP0006276_abnormal_autonomic_nervous0.59914634
129MP0010329_abnormal_lipoprotein_level0.58617486
130MP0004859_abnormal_synaptic_plasticity0.58232808
131MP0003329_amyloid_beta_deposits0.57983441
132MP0003828_pulmonary_edema0.57722291
133MP0002069_abnormal_eating/drinking_beha0.57233462
134MP0000609_abnormal_liver_physiology0.55184900
135MP0003866_abnormal_defecation0.54636747
136MP0001270_distended_abdomen0.54532868
137MP0000538_abnormal_urinary_bladder0.53497263
138MP0001970_abnormal_pain_threshold0.52922002
139MP0003633_abnormal_nervous_system0.52212734
140MP0009642_abnormal_blood_homeostasis0.52157278
141MP0000631_abnormal_neuroendocrine_gland0.51874933
142MP0004036_abnormal_muscle_relaxation0.51588406
143MP0002295_abnormal_pulmonary_circulatio0.51278920
144MP0003045_fibrosis0.50236491
145MP0004215_abnormal_myocardial_fiber0.50103903
146MP0001919_abnormal_reproductive_system0.48560536
147MP0005332_abnormal_amino_acid0.47713780

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.40289907
2Hypoglycemic seizures (HP:0002173)7.39917607
3Hypoglycemic coma (HP:0001325)7.23190482
4Symptomatic seizures (HP:0011145)6.64246190
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.38349855
6Myokymia (HP:0002411)5.44392213
7Ketoacidosis (HP:0001993)5.09064185
8Insulin-resistant diabetes mellitus (HP:0000831)4.69914724
9Hyperglycemia (HP:0003074)4.50359637
10Decreased circulating renin level (HP:0003351)4.49056082
11Abnormality of calcium-phosphate metabolism (HP:0100530)4.48296132
12Late onset (HP:0003584)4.40563284
13Focal motor seizures (HP:0011153)4.27992908
14Hypomagnesemia (HP:0002917)4.25676862
15Abnormality of endocrine pancreas physiology (HP:0012093)3.98263469
16Abnormality of the pancreatic islet cells (HP:0006476)3.98263469
17Abnormal pancreas size (HP:0012094)3.91082831
18Split foot (HP:0001839)3.90256851
19Abnormality of magnesium homeostasis (HP:0004921)3.86727849
20Febrile seizures (HP:0002373)3.78291561
21Absence seizures (HP:0002121)3.69993742
22Insulin resistance (HP:0000855)3.68789843
23Abnormal drinking behavior (HP:0030082)3.63833093
24Polydipsia (HP:0001959)3.63833093
25Hyperactive renin-angiotensin system (HP:0000841)3.56687474
26Focal seizures (HP:0007359)3.55521443
27Large for gestational age (HP:0001520)3.48805665
28Action tremor (HP:0002345)3.44406881
29Generalized aminoaciduria (HP:0002909)3.37522220
30Mucopolysacchariduria (HP:0008155)3.36076566
31Urinary glycosaminoglycan excretion (HP:0003541)3.36076566
32Hyperparathyroidism (HP:0000843)3.27883667
33Dysostosis multiplex (HP:0000943)3.24487012
34Abnormality of aromatic amino acid family metabolism (HP:0004338)3.21452971
35Ketosis (HP:0001946)3.17772058
36Abnormal eating behavior (HP:0100738)3.16249573
37Oligomenorrhea (HP:0000876)3.15421590
38Hypokalemia (HP:0002900)3.14220130
39Generalized tonic-clonic seizures (HP:0002069)3.13358651
40Obstructive sleep apnea (HP:0002870)3.13265790
41Tetany (HP:0001281)3.12687072
42Pancreatic islet-cell hyperplasia (HP:0004510)3.02027041
43Abnormality of mucopolysaccharide metabolism (HP:0011020)3.00269040
44Abnormality of polysaccharide metabolism (HP:0011012)3.00269040
45Abnormality of glycosaminoglycan metabolism (HP:0004371)3.00269040
46Pheochromocytoma (HP:0002666)2.98828318
47Growth hormone excess (HP:0000845)2.98160990
48Dialeptic seizures (HP:0011146)2.98081885
49Lymphangioma (HP:0100764)2.92146856
50Agitation (HP:0000713)2.91083177
51Torticollis (HP:0000473)2.89875774
52Hyperkalemia (HP:0002153)2.88649954
53Hypercortisolism (HP:0001578)2.88484143
54Chronic bronchitis (HP:0004469)2.85768209
55Gout (HP:0001997)2.78654458
56Ventricular fibrillation (HP:0001663)2.78116605
57Limb hypertonia (HP:0002509)2.76772313
58Abnormality of renin-angiotensin system (HP:0000847)2.76724063
59Epileptic encephalopathy (HP:0200134)2.75544309
60Hypokalemic alkalosis (HP:0001949)2.71862300
61Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.70695287
62Atonic seizures (HP:0010819)2.66043227
63Menstrual irregularities (HP:0000858)2.65256566
64Abnormality of chloride homeostasis (HP:0011422)2.63855857
65Adrenal overactivity (HP:0002717)2.58966502
66Neuroendocrine neoplasm (HP:0100634)2.58283402
67Focal dystonia (HP:0004373)2.56696656
68Diplopia (HP:0000651)2.56167475
69Abnormality of binocular vision (HP:0011514)2.56167475
70Acanthosis nigricans (HP:0000956)2.55212318
71Cerebral inclusion bodies (HP:0100314)2.53963712
72Thoracolumbar scoliosis (HP:0002944)2.52972847
73Hyperuricemia (HP:0002149)2.52619412
74Increased purine levels (HP:0004368)2.52619412
75Visual hallucinations (HP:0002367)2.51940467
76Polyuria (HP:0000103)2.50867225
77Osteomalacia (HP:0002749)2.50482866
78Craniofacial dystonia (HP:0012179)2.49448911
79Abnormality of potassium homeostasis (HP:0011042)2.49424110
80Neurofibrillary tangles (HP:0002185)2.48032202
81Bronchomalacia (HP:0002780)2.45183196
82Dysautonomia (HP:0002459)2.44186295
83Supranuclear gaze palsy (HP:0000605)2.42902693
84Abnormality of the intrinsic pathway (HP:0010989)2.42716373
85Abnormal urine output (HP:0012590)2.41206322
86Athetosis (HP:0002305)2.41005632
87Papilledema (HP:0001085)2.40653920
88Thyroid-stimulating hormone excess (HP:0002925)2.36604871
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.35493162
90Hypotension (HP:0002615)2.35089129
91Ankle clonus (HP:0011448)2.34265749
92Myoglobinuria (HP:0002913)2.33964623
93Abnormality of renal excretion (HP:0011036)2.33529170
94Axonal loss (HP:0003447)2.33297008
95Progressive neurologic deterioration (HP:0002344)2.32736495
96Complement deficiency (HP:0004431)2.30566410
97Hyperaldosteronism (HP:0000859)2.29448861
98Bundle branch block (HP:0011710)2.25270950
99Hyperphosphatemia (HP:0002905)2.22279949
100Hypothermia (HP:0002045)2.22039945
101Hemiplegia (HP:0002301)2.21413365
102Progressive cerebellar ataxia (HP:0002073)2.21117212
103Hepatic necrosis (HP:0002605)2.21079487
104Hyperthyroidism (HP:0000836)2.19435201
105Postural instability (HP:0002172)2.19269645
106Acute hepatic failure (HP:0006554)2.18884215
107Hypercalciuria (HP:0002150)2.17855112
108Renal tubular acidosis (HP:0001947)2.16532081
109Truncal ataxia (HP:0002078)2.14546003
110Hyporeflexia of lower limbs (HP:0002600)2.12676788
111Fibular aplasia (HP:0002990)2.12126550
112Mitral stenosis (HP:0001718)2.08704214
113Intention tremor (HP:0002080)2.08620246
114Prolonged QT interval (HP:0001657)2.08477371
115Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06956059
116Abnormal protein N-linked glycosylation (HP:0012347)2.06956059
117Abnormal protein glycosylation (HP:0012346)2.06956059
118Abnormal glycosylation (HP:0012345)2.06956059
119Bradycardia (HP:0001662)2.06868304
120Sleep apnea (HP:0010535)2.06542541
121Bone cyst (HP:0012062)2.06270414
122Vascular calcification (HP:0004934)2.06203364
123Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.04244530
124Exocrine pancreatic insufficiency (HP:0001738)2.04109409
125Syncope (HP:0001279)2.03560486
126Unilateral renal agenesis (HP:0000122)2.03196820
127Stridor (HP:0010307)2.02702949
128Vacuolated lymphocytes (HP:0001922)2.01496773
129Retinal atrophy (HP:0001105)2.01455814
130Polyphagia (HP:0002591)1.99231322
131Polygenic inheritance (HP:0010982)1.98634243
132Bell-shaped thorax (HP:0001591)1.96994220
133Hemiparesis (HP:0001269)1.93468392
134Heart block (HP:0012722)1.93279691
135Goiter (HP:0000853)1.92146790
136Abdominal distention (HP:0003270)1.92053279
137Neoplasm of the heart (HP:0100544)1.90009328
138Type I diabetes mellitus (HP:0100651)1.88135461
139Dysmetria (HP:0001310)1.87957087
140Abnormal atrioventricular conduction (HP:0005150)1.87757347
141Hyperlipoproteinemia (HP:0010980)1.85662264
142Type I transferrin isoform profile (HP:0003642)1.84634965
143Humeroradial synostosis (HP:0003041)1.82885301
144Synostosis involving the elbow (HP:0003938)1.82885301
145Mutism (HP:0002300)1.82858300
146Dysdiadochokinesis (HP:0002075)1.82169734
147Abnormality of the fovea (HP:0000493)1.81442847
148Neonatal onset (HP:0003623)1.81429996
149Rigidity (HP:0002063)1.80366341
150Metaphyseal dysplasia (HP:0100255)1.78933970
151Atrial fibrillation (HP:0005110)1.78233207
152Wrist flexion contracture (HP:0001239)1.77631160
153Nonprogressive disorder (HP:0003680)1.77559133
154Sudden death (HP:0001699)1.77268748
155Renal salt wasting (HP:0000127)1.76865176
156Abnormal EKG (HP:0003115)1.76116682
157Dicarboxylic aciduria (HP:0003215)1.75569974
158Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75569974
159EEG with generalized epileptiform discharges (HP:0011198)1.75210107
160Increased cerebral lipofuscin (HP:0011813)1.75031585
161Maternal diabetes (HP:0009800)1.73379656
162Hypsarrhythmia (HP:0002521)1.73073418
163Increased neuronal autofluorescent lipopigment (HP:0002074)1.72904060
164Primary adrenal insufficiency (HP:0008207)1.71255829
165Abnormality of purine metabolism (HP:0004352)1.70565678
166Anxiety (HP:0000739)1.69935753
167Epileptiform EEG discharges (HP:0011182)1.69483112
168Increased circulating renin level (HP:0000848)1.67873343
169Neoplasm of the adrenal gland (HP:0100631)1.66536407
170Restlessness (HP:0000711)1.65299022
171Prominent metopic ridge (HP:0005487)1.65080172
172Protuberant abdomen (HP:0001538)1.63521198
173Irregular vertebral endplates (HP:0003301)1.62966459
174Glycosuria (HP:0003076)1.62202890
175Abnormality of urine glucose concentration (HP:0011016)1.62202890
176Irritability (HP:0000737)1.61047359
177Abnormal rod and cone electroretinograms (HP:0008323)1.60365082
178Hypophosphatemia (HP:0002148)1.60216137
179Abnormal mitochondria in muscle tissue (HP:0008316)1.59634942
180Congenital glaucoma (HP:0001087)1.56051286
181Congenital sensorineural hearing impairment (HP:0008527)1.55917417

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.90434684
2INSRR6.02668603
3PASK5.49236980
4ERN13.69819959
5PRKD32.98406105
6WNK32.81532932
7EPHA42.78525794
8FLT32.61139362
9NTRK12.59682696
10WNK42.55424610
11HIPK22.31864654
12MARK12.29138093
13BCKDK2.18932838
14TIE12.12370676
15NTRK31.86641922
16PIK3CG1.81066568
17KDR1.78741344
18EPHA31.76695512
19PDGFRA1.72352007
20NTRK21.68867629
21MAP3K21.64788287
22MAPK121.62491824
23PINK11.60487606
24MAP2K21.46898147
25STK391.46521978
26ABL21.46236075
27TRIB31.45265505
28PHKG21.40655214
29PHKG11.40655214
30PKN11.37734923
31LATS21.37649485
32PRPF4B1.37636548
33MET1.33713633
34SGK4941.30475579
35SGK2231.30475579
36PAK31.30454105
37FRK1.29756499
38MAPKAPK31.28441859
39STK381.23420707
40PTK21.20505745
41CAMKK21.15307233
42DMPK1.14200191
43FER1.10488737
44DYRK1B1.10198418
45PDPK11.08792981
46IRAK11.07497547
47CAMK2G1.00952551
48LIMK10.97453238
49TESK10.96799193
50FGFR20.96249772
51TAOK20.96167135
52MAP3K10.95409363
53MAP3K90.93892742
54CAMK2A0.93406789
55MARK20.93200147
56GRK10.93013948
57BRSK10.92245275
58KSR20.85729239
59CDC42BPA0.85618702
60PDK10.85552742
61UHMK10.84594252
62MINK10.83320783
63ERBB20.82246121
64DAPK30.81036154
65EPHA20.80907928
66SGK20.79462760
67PRKCH0.79180025
68MAPK40.78584556
69PRKD20.78322285
70MAP2K10.77734057
71LMTK20.77366280
72SCYL20.76534586
73SIK10.75105108
74MAP3K110.75014818
75CASK0.73863703
76EPHB10.69395526
77KIT0.69361491
78EPHB20.69106706
79PRKAA20.68996980
80SGK10.68023985
81ARAF0.66578573
82BRAF0.66538021
83TBK10.66107696
84MYLK0.65382011
85JAK30.65341543
86FGFR40.65338409
87BCR0.65076776
88MAPK100.63083259
89DYRK30.62882890
90MAP2K60.62848856
91CAMK40.62333792
92AKT30.62152058
93ROCK10.60992776
94ZAP700.60941765
95ROCK20.58819820
96IRAK30.57959046
97PLK20.53661004
98RPS6KA30.53482063
99PRKG20.53141668
100EIF2AK30.52229806
101PRKCE0.51449381
102JAK20.50033577
103CDK11A0.50010478
104DDR20.49709714
105SGK30.48585946
106RET0.48372233
107IKBKE0.47721204
108STK110.47600451
109TLK10.46847672
110CSK0.46242473
111PRKG10.45439406
112CDK50.45070462
113BMPR20.41259139
114RPS6KA20.40338948
115PRKCI0.39438092
116NLK0.38992695
117DYRK1A0.38365420
118CAMK1G0.38131663
119PTK60.36616630
120WNK10.36205469
121CAMKK10.35655105
122IGF1R0.35202273
123DAPK20.35093084
124RIPK10.33831728
125ITK0.31615301
126JAK10.31442086
127GSK3A0.30237231
128PAK60.30039127
129CAMK2D0.29937838
130PRKACG0.28609760
131TGFBR20.28131959
132CAMK10.27255035
133CAMK2B0.26560787
134PDGFRB0.24307279
135TAOK30.24102801
136CDK90.22597890
137MAPK30.22356105
138PRKACA0.21940687
139PRKAA10.21689447
140PRKCG0.20812219
141PTK2B0.20520494
142CSNK1A10.20510104
143PRKD10.20242951
144CAMK1D0.19022463
145CHUK0.18724802
146GRK50.18685615
147ADRBK10.18475252
148DAPK10.17996196
149MAPK70.17522776
150STK160.16133437
151MAPK90.15397570
152IRAK20.15234121
153PDK20.14537720
154NEK60.13767157

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.19362056
2Protein export_Homo sapiens_hsa030605.37148227
3Sulfur metabolism_Homo sapiens_hsa009203.15264932
4Insulin secretion_Homo sapiens_hsa049112.88798512
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.60771819
6Vibrio cholerae infection_Homo sapiens_hsa051102.59059944
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.30201310
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.29305672
9Nicotine addiction_Homo sapiens_hsa050332.12559436
10Vitamin B6 metabolism_Homo sapiens_hsa007501.90531667
11Type II diabetes mellitus_Homo sapiens_hsa049301.79788115
12Cocaine addiction_Homo sapiens_hsa050301.73131053
13Glutamatergic synapse_Homo sapiens_hsa047241.61050236
14Carbohydrate digestion and absorption_Homo sapiens_hsa049731.60566345
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51638852
16Amphetamine addiction_Homo sapiens_hsa050311.50854668
17N-Glycan biosynthesis_Homo sapiens_hsa005101.38951869
18Folate biosynthesis_Homo sapiens_hsa007901.38403793
19Lysosome_Homo sapiens_hsa041421.37713894
20Ovarian steroidogenesis_Homo sapiens_hsa049131.36517481
21Bile secretion_Homo sapiens_hsa049761.33893339
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32918206
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26732964
24Arginine biosynthesis_Homo sapiens_hsa002201.26391753
25Circadian rhythm_Homo sapiens_hsa047101.26307162
26Synaptic vesicle cycle_Homo sapiens_hsa047211.25364712
27Selenocompound metabolism_Homo sapiens_hsa004501.24035132
28Other glycan degradation_Homo sapiens_hsa005111.22566028
29Collecting duct acid secretion_Homo sapiens_hsa049661.19912285
30Tryptophan metabolism_Homo sapiens_hsa003801.19842951
31beta-Alanine metabolism_Homo sapiens_hsa004101.19678838
32Butanoate metabolism_Homo sapiens_hsa006501.17183359
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17003921
34Type I diabetes mellitus_Homo sapiens_hsa049401.11378504
35Glucagon signaling pathway_Homo sapiens_hsa049221.11111051
36Regulation of autophagy_Homo sapiens_hsa041401.10799167
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07739738
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.06557937
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05039756
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04711366
41Oxidative phosphorylation_Homo sapiens_hsa001901.03060700
42Fatty acid biosynthesis_Homo sapiens_hsa000611.02523328
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02461342
44Taste transduction_Homo sapiens_hsa047421.02342713
45Thyroid hormone synthesis_Homo sapiens_hsa049180.99620698
46Insulin resistance_Homo sapiens_hsa049310.99431926
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97831859
48Long-term potentiation_Homo sapiens_hsa047200.96628515
49Calcium signaling pathway_Homo sapiens_hsa040200.95021036
50Pancreatic secretion_Homo sapiens_hsa049720.94697586
51Phenylalanine metabolism_Homo sapiens_hsa003600.93816321
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92099983
53Galactose metabolism_Homo sapiens_hsa000520.91038224
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90366470
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.89140560
56Dopaminergic synapse_Homo sapiens_hsa047280.88767450
57Mineral absorption_Homo sapiens_hsa049780.88404843
58Fatty acid degradation_Homo sapiens_hsa000710.88290756
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84384661
60* Circadian entrainment_Homo sapiens_hsa047130.84170514
61Prion diseases_Homo sapiens_hsa050200.82776120
62ABC transporters_Homo sapiens_hsa020100.81268766
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81016316
64Arginine and proline metabolism_Homo sapiens_hsa003300.79029726
65Phototransduction_Homo sapiens_hsa047440.77993966
66Cardiac muscle contraction_Homo sapiens_hsa042600.77431066
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.76832656
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76443254
69Fatty acid metabolism_Homo sapiens_hsa012120.76178178
70Fatty acid elongation_Homo sapiens_hsa000620.75632653
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74682219
72Dilated cardiomyopathy_Homo sapiens_hsa054140.73265241
73Alzheimers disease_Homo sapiens_hsa050100.73027829
74Estrogen signaling pathway_Homo sapiens_hsa049150.72970667
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72754692
76GnRH signaling pathway_Homo sapiens_hsa049120.72542216
77Complement and coagulation cascades_Homo sapiens_hsa046100.72131960
78Renin secretion_Homo sapiens_hsa049240.70168090
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.70065722
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69980313
81Prolactin signaling pathway_Homo sapiens_hsa049170.68994619
82GABAergic synapse_Homo sapiens_hsa047270.68635398
83Tight junction_Homo sapiens_hsa045300.67928046
84Cholinergic synapse_Homo sapiens_hsa047250.67250860
85Serotonergic synapse_Homo sapiens_hsa047260.65495868
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64368493
87Histidine metabolism_Homo sapiens_hsa003400.64247920
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64008420
89Parkinsons disease_Homo sapiens_hsa050120.63348365
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62743907
91Insulin signaling pathway_Homo sapiens_hsa049100.59353786
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58703614
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57658095
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57181961
95Melanogenesis_Homo sapiens_hsa049160.55888168
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55878130
97cAMP signaling pathway_Homo sapiens_hsa040240.55753407
98Propanoate metabolism_Homo sapiens_hsa006400.55743599
99Long-term depression_Homo sapiens_hsa047300.54901496
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.54896090
101Tyrosine metabolism_Homo sapiens_hsa003500.54768850
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54524155
103Morphine addiction_Homo sapiens_hsa050320.53892069
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53511101
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53282266
106Fat digestion and absorption_Homo sapiens_hsa049750.51571600
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.51482201
108Sulfur relay system_Homo sapiens_hsa041220.51024776
109Pyruvate metabolism_Homo sapiens_hsa006200.50574013
110Nitrogen metabolism_Homo sapiens_hsa009100.49554788
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.46865300
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46395794
113Gap junction_Homo sapiens_hsa045400.45847538
114MAPK signaling pathway_Homo sapiens_hsa040100.45754266
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44500526
116Retinol metabolism_Homo sapiens_hsa008300.44060965
117Starch and sucrose metabolism_Homo sapiens_hsa005000.42015640
118Linoleic acid metabolism_Homo sapiens_hsa005910.41182444
119Fructose and mannose metabolism_Homo sapiens_hsa000510.40786648
120Sphingolipid metabolism_Homo sapiens_hsa006000.40460893
121AMPK signaling pathway_Homo sapiens_hsa041520.39886975
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39773177
123Gastric acid secretion_Homo sapiens_hsa049710.37107927
124Alcoholism_Homo sapiens_hsa050340.35676967
125PPAR signaling pathway_Homo sapiens_hsa033200.33596779
126Huntingtons disease_Homo sapiens_hsa050160.33500714
127Salivary secretion_Homo sapiens_hsa049700.30980222
128Peroxisome_Homo sapiens_hsa041460.30670243
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29432020
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28111067
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26170330
132Rheumatoid arthritis_Homo sapiens_hsa053230.25955331
133Antigen processing and presentation_Homo sapiens_hsa046120.25238685
134Glycerolipid metabolism_Homo sapiens_hsa005610.24917314
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23722410
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21540960
137Protein digestion and absorption_Homo sapiens_hsa049740.21473788
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20832574
139Oxytocin signaling pathway_Homo sapiens_hsa049210.20112457
140Legionellosis_Homo sapiens_hsa051340.19803336
141Endocytosis_Homo sapiens_hsa041440.19583957
142Phagosome_Homo sapiens_hsa041450.19229836

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