RASGEF1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)5.77233116
2modulation by symbiont of host defense response (GO:0052031)5.77233116
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.77233116
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.77233116
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.77233116
6modulation by symbiont of host immune response (GO:0052553)5.77233116
7response to muramyl dipeptide (GO:0032495)5.10460101
8negative regulation of interleukin-1 beta production (GO:0032691)5.00164240
9modulation by symbiont of host cellular process (GO:0044068)4.60955542
10response to peptidoglycan (GO:0032494)4.36313364
11neutrophil activation involved in immune response (GO:0002283)4.34635912
12positive regulation of cellular amide metabolic process (GO:0034250)4.20099112
13macrophage activation involved in immune response (GO:0002281)4.13865686
14positive regulation of heat generation (GO:0031652)4.10218657
15negative regulation of interleukin-1 production (GO:0032692)4.06247959
16germinal center formation (GO:0002467)4.05023006
17indole-containing compound catabolic process (GO:0042436)3.99765439
18indolalkylamine catabolic process (GO:0046218)3.99765439
19tryptophan catabolic process (GO:0006569)3.99765439
20positive regulation of gamma-delta T cell activation (GO:0046645)3.98207142
21neutrophil mediated immunity (GO:0002446)3.95268763
22positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.93997639
23natural killer cell mediated cytotoxicity (GO:0042267)3.88074468
24natural killer cell mediated immunity (GO:0002228)3.88074468
25positive regulation of interleukin-1 beta secretion (GO:0050718)3.86448633
26regulation of germinal center formation (GO:0002634)3.85536959
27regulation of interferon-beta biosynthetic process (GO:0045357)3.83023268
28NIK/NF-kappaB signaling (GO:0038061)3.76999588
29cell adhesion mediated by integrin (GO:0033627)3.75118192
30regulation of interleukin-12 biosynthetic process (GO:0045075)3.74782866
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.73478232
32response to host immune response (GO:0052572)3.73478232
33DNA deamination (GO:0045006)3.67645185
34microglial cell activation (GO:0001774)3.61949227
35positive regulation of interleukin-1 secretion (GO:0050716)3.58319999
36positive regulation of interferon-alpha production (GO:0032727)3.55173655
37B cell homeostasis (GO:0001782)3.52226935
38lipopolysaccharide-mediated signaling pathway (GO:0031663)3.51894097
39cytokine secretion (GO:0050663)3.50853757
40negative regulation of mast cell activation (GO:0033004)3.50491466
41regulation of interleukin-1 beta secretion (GO:0050706)3.49439912
42indolalkylamine metabolic process (GO:0006586)3.47387152
43kynurenine metabolic process (GO:0070189)3.45795860
44negative regulation of lipid storage (GO:0010888)3.43550531
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.42085384
46regulation of interferon-alpha production (GO:0032647)3.41183806
47I-kappaB phosphorylation (GO:0007252)3.40478928
48tryptophan metabolic process (GO:0006568)3.39724901
49regulation of fever generation (GO:0031620)3.37949272
50response to host (GO:0075136)3.37550719
51response to host defenses (GO:0052200)3.37550719
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.37550719
53positive regulation of T-helper 1 type immune response (GO:0002827)3.35968764
54cellular response to virus (GO:0098586)3.35047617
55positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.34041152
56regulation of integrin activation (GO:0033623)3.33141915
57developmental pigmentation (GO:0048066)3.31626843
58positive regulation of interleukin-12 production (GO:0032735)3.29563611
59modulation by virus of host process (GO:0019054)3.28519042
60regulation of heat generation (GO:0031650)3.21395427
61detection of biotic stimulus (GO:0009595)3.21311934
62wound healing, spreading of epidermal cells (GO:0035313)3.20325089
63positive regulation of prostaglandin secretion (GO:0032308)3.20053295
64protein K11-linked deubiquitination (GO:0035871)3.18276695
65neural tube formation (GO:0001841)3.18147036
66positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.15456671
67positive regulation of defense response to virus by host (GO:0002230)3.14471215
68regulation of interleukin-1 secretion (GO:0050704)3.10368796
69positive regulation of chemokine biosynthetic process (GO:0045080)3.09742122
70granulocyte activation (GO:0036230)3.08521293
71virion attachment to host cell (GO:0019062)3.06799311
72adhesion of symbiont to host cell (GO:0044650)3.06799311
73regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.06775500
74myeloid cell activation involved in immune response (GO:0002275)3.04536571
75respiratory burst (GO:0045730)3.04419266
76regulation of B cell receptor signaling pathway (GO:0050855)3.01789861
77positive regulation of interleukin-1 beta production (GO:0032731)3.01640669
78neutrophil activation (GO:0042119)3.01390402
79negative regulation of interleukin-17 production (GO:0032700)3.00604652
80behavioral response to nicotine (GO:0035095)2.99591563
81leukocyte mediated cytotoxicity (GO:0001909)2.98225410
82myeloid leukocyte mediated immunity (GO:0002444)2.97861741
83negative regulation of acute inflammatory response (GO:0002674)2.97489115
84positive regulation of oligodendrocyte differentiation (GO:0048714)2.96625518
85regulation of memory T cell differentiation (GO:0043380)2.95937125
86positive regulation of actin filament depolymerization (GO:0030836)2.95638510
87regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90731493
88regulation of interleukin-8 biosynthetic process (GO:0045414)2.89919027
89negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.89459185
90positive regulation of B cell differentiation (GO:0045579)2.88859067
91regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.85843677
92RNA destabilization (GO:0050779)2.85501354
93positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.85484314
94response to lipoprotein particle (GO:0055094)2.84883938
95negative regulation of cell killing (GO:0031342)2.84483526
96negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.84483526
97modification by symbiont of host morphology or physiology (GO:0044003)2.81973036
98mitotic cell cycle arrest (GO:0071850)2.81651607
99regulation of T-helper 1 type immune response (GO:0002825)2.79357749
100immunoglobulin mediated immune response (GO:0016064)2.78597527
101positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.76508532
102adaptation of signaling pathway (GO:0023058)2.76374119
103positive regulation of protein homooligomerization (GO:0032464)2.75225762
104cellular response to ATP (GO:0071318)2.74513216
105regulation of alkaline phosphatase activity (GO:0010692)2.74512366
106positive regulation of humoral immune response (GO:0002922)2.74362470
107positive regulation of interferon-beta production (GO:0032728)2.72172704
108sulfation (GO:0051923)2.72170681
109positive regulation of interleukin-1 production (GO:0032732)2.71972281
110interferon-gamma production (GO:0032609)2.71476958
111protein kinase C signaling (GO:0070528)2.71475521
112macrophage activation (GO:0042116)2.71265186
113leukocyte aggregation (GO:0070486)2.70746476
114myeloid cell homeostasis (GO:0002262)2.70660806
115cornea development in camera-type eye (GO:0061303)2.70493821
116positive regulation of antigen processing and presentation (GO:0002579)2.70315239
117regulation of chronic inflammatory response (GO:0002676)2.70136400
118cellular biogenic amine catabolic process (GO:0042402)2.69762994
119amine catabolic process (GO:0009310)2.69762994
120hydrogen peroxide biosynthetic process (GO:0050665)2.69526046
121platelet dense granule organization (GO:0060155)2.69393557
122negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.69383116
123eosinophil chemotaxis (GO:0048245)2.69136599
124myeloid dendritic cell differentiation (GO:0043011)2.69092034
125regulation of prostaglandin secretion (GO:0032306)2.69052250
126negative regulation of NF-kappaB import into nucleus (GO:0042347)2.68755142
127macroautophagy (GO:0016236)2.67850572
128fucose catabolic process (GO:0019317)2.65820785
129L-fucose metabolic process (GO:0042354)2.65820785
130L-fucose catabolic process (GO:0042355)2.65820785
131B cell receptor signaling pathway (GO:0050853)2.65601178
132regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.65137562
133regulation of interleukin-17 production (GO:0032660)2.64596924
134cellular response to molecule of bacterial origin (GO:0071219)2.64567589
135positive regulation of fatty acid transport (GO:2000193)2.64559366
136T-helper cell differentiation (GO:0042093)2.64475979
137CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.64475979
138regulation of interleukin-12 production (GO:0032655)2.63468938
139cell wall macromolecule catabolic process (GO:0016998)2.60885961
140positive regulation of cAMP-mediated signaling (GO:0043950)2.55700126
141detection of light stimulus involved in visual perception (GO:0050908)2.50731793
142detection of light stimulus involved in sensory perception (GO:0050962)2.50731793
143indole-containing compound metabolic process (GO:0042430)2.49309731
144positive regulation of icosanoid secretion (GO:0032305)2.48946227
145negative regulation of systemic arterial blood pressure (GO:0003085)2.48765443
146limb bud formation (GO:0060174)2.47639720
147T cell differentiation involved in immune response (GO:0002292)2.47506109
148alpha-beta T cell differentiation involved in immune response (GO:0002293)2.47506109
149alpha-beta T cell activation involved in immune response (GO:0002287)2.47506109
150eosinophil migration (GO:0072677)2.46239215
151negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.42802564
152negative regulation of T-helper cell differentiation (GO:0045623)2.42802564
153keratinocyte development (GO:0003334)2.41220292
154positive regulation of osteoclast differentiation (GO:0045672)2.40203871
155endoderm formation (GO:0001706)2.40172157
156regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.40091236
157mast cell activation (GO:0045576)2.39673719
158negative regulation of interleukin-12 production (GO:0032695)2.39167081
159regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.39096329
160cell wall macromolecule metabolic process (GO:0044036)2.34956007
161cellular response to exogenous dsRNA (GO:0071360)2.34007723
162somite development (GO:0061053)2.33843058
163glial cell proliferation (GO:0014009)2.33583453
164positive regulation of glomerulus development (GO:0090193)2.33305572
165embryonic epithelial tube formation (GO:0001838)2.31400018
166rRNA catabolic process (GO:0016075)2.30750617
167response to xenobiotic stimulus (GO:0009410)2.30560189
168activated T cell proliferation (GO:0050798)2.30198934
169regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.29373992
170negative regulation of protein oligomerization (GO:0032460)2.28674052
171negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.28307750
172regulation of inflammatory response to antigenic stimulus (GO:0002861)2.26355957
173prostate gland growth (GO:0060736)2.25748118
174aromatic amino acid family catabolic process (GO:0009074)2.25401598
175cellular response to ethanol (GO:0071361)2.25124500
176protein localization to cilium (GO:0061512)2.24534567
177alpha-beta T cell differentiation (GO:0046632)2.24433142
178positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.24208985
179proline transport (GO:0015824)2.23887832
180regulation of collateral sprouting (GO:0048670)2.23031020
181regulation of mast cell activation (GO:0033003)2.22761921
182preassembly of GPI anchor in ER membrane (GO:0016254)2.22317837
183regulation of T-helper cell differentiation (GO:0045622)2.20936635
184positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.20455471
185benzene-containing compound metabolic process (GO:0042537)2.19646345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.27419835
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.20171674
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.75722896
4* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.17825927
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.98353424
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.77161976
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.11620566
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.06214469
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92855010
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.78785812
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.61519838
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.58288389
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.53384371
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.49541158
15ZNF274_21170338_ChIP-Seq_K562_Hela2.46843068
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.46607012
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.41316668
18VDR_22108803_ChIP-Seq_LS180_Human2.38256708
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37941635
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.36567304
21SCL_19346495_ChIP-Seq_HPC-7_Human2.36396389
22VDR_24787735_ChIP-Seq_THP-1_Human2.35943193
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.29977121
24IGF1R_20145208_ChIP-Seq_DFB_Human2.25702348
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15476322
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13028815
27* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse2.04081485
28SPI1_23127762_ChIP-Seq_K562_Human1.96997421
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.93740701
30* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.89827194
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.88814150
32TAF15_26573619_Chip-Seq_HEK293_Human1.84549794
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.81599386
34RUNX_20019798_ChIP-Seq_JUKART_Human1.81238840
35VDR_24763502_ChIP-Seq_THP-1_Human1.78531503
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.75670603
37* P300_19829295_ChIP-Seq_ESCs_Human1.75523919
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.74828391
39NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.74408928
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59494052
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57640637
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56226390
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55793921
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55704458
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55694758
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53973197
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53067279
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51824853
49CBP_20019798_ChIP-Seq_JUKART_Human1.51390013
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51390013
51* PU_27001747_Chip-Seq_BMDM_Mouse1.50413699
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.49165220
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.47394606
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46932742
55AR_25329375_ChIP-Seq_VCAP_Human1.40217182
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39712731
57BCAT_22108803_ChIP-Seq_LS180_Human1.39550710
58EWS_26573619_Chip-Seq_HEK293_Human1.39368129
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38114160
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36407083
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36219498
62* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36151419
63* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35776714
64* SMAD4_21799915_ChIP-Seq_A2780_Human1.31683523
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31391258
66* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30148043
67* SMAD3_21741376_ChIP-Seq_EPCs_Human1.29946180
68EZH2_22144423_ChIP-Seq_EOC_Human1.26716359
69SPI1_23547873_ChIP-Seq_NB4_Human1.26452300
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.25589875
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.25423125
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24844491
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.24590175
74SOX2_19829295_ChIP-Seq_ESCs_Human1.23996613
75NANOG_19829295_ChIP-Seq_ESCs_Human1.23996613
76CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22467751
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21938608
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21557969
79* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21089618
80* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20801474
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20120296
82P53_22387025_ChIP-Seq_ESCs_Mouse1.19958950
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19758999
84* PRDM14_20953172_ChIP-Seq_ESCs_Human1.19642901
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19347162
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.19271610
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18830378
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18210695
89FUS_26573619_Chip-Seq_HEK293_Human1.17716468
90IRF1_19129219_ChIP-ChIP_H3396_Human1.16493383
91* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16388243
92CDX2_22108803_ChIP-Seq_LS180_Human1.16083586
93STAT3_23295773_ChIP-Seq_U87_Human1.15196211
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.13698678
95TCF4_22108803_ChIP-Seq_LS180_Human1.13660699
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12995784
97TCF4_23295773_ChIP-Seq_U87_Human1.12858835
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12464127
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12183645
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12115603
101BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11084482
102E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11079824
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10678322
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10329209
105TP53_22573176_ChIP-Seq_HFKS_Human1.10113513
106* PIAS1_25552417_ChIP-Seq_VCAP_Human1.09184391
107OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09066879
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08716202
109FOXA1_25329375_ChIP-Seq_VCAP_Human1.06990390
110FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06990390
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.05946838
112MYB_26560356_Chip-Seq_TH2_Human1.05428554
113SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05297653
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05173430
115SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04746382
116NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04248762
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04248762
118* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04110846
119RUNX1_22412390_ChIP-Seq_EML_Mouse1.03840485
120SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03144318
121GATA1_22025678_ChIP-Seq_K562_Human1.03122353
122E2F1_18555785_Chip-Seq_ESCs_Mouse1.01725087
123VDR_21846776_ChIP-Seq_THP-1_Human1.01681643
124FOXO3_23340844_ChIP-Seq_DLD1_Human1.00744789
125CMYC_18555785_Chip-Seq_ESCs_Mouse1.00231373
126* RUNX2_22187159_ChIP-Seq_PCA_Human0.99732089
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99714611
128GATA3_21878914_ChIP-Seq_MCF-7_Human0.99526186
129STAT3_18555785_Chip-Seq_ESCs_Mouse0.99354576
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98628097
131GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98578580
132RXR_22108803_ChIP-Seq_LS180_Human0.97293425
133REST_21632747_ChIP-Seq_MESCs_Mouse0.96828072
134AHR_22903824_ChIP-Seq_MCF-7_Human0.96171742
135SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93978887
136* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93860973
137TP53_16413492_ChIP-PET_HCT116_Human0.92413419
138WT1_19549856_ChIP-ChIP_CCG9911_Human0.91707690
139CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91626926
140CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90352713
141CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89427355
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88946467
143KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88627295
144RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86850387
145THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86698669
146* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86533565
147* MYB_26560356_Chip-Seq_TH1_Human0.86225742
148GATA3_27048872_Chip-Seq_THYMUS_Human0.86085362
149SMRT_27268052_Chip-Seq_Bcells_Human0.86018104
150SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85851733
151MAF_26560356_Chip-Seq_TH1_Human0.85405936
152GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84744977
153CDX2_20551321_ChIP-Seq_CACO-2_Human0.83647016
154GBX2_23144817_ChIP-Seq_PC3_Human0.83476484
155* GATA2_19941826_ChIP-Seq_K562_Human0.83089952
156SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82655247
157STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82179730
158TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81280905
159TCF7_22412390_ChIP-Seq_EML_Mouse0.80817445
160PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80729099
161PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80164956
162* GATA3_26560356_Chip-Seq_TH2_Human0.79965324
163CJUN_26792858_Chip-Seq_BT549_Human0.78436609
164TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76461946
165PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75940129
166DROSHA_22980978_ChIP-Seq_HELA_Human0.75776279
167GATA1_19941827_ChIP-Seq_MEL_Mouse0.75244679
168ER_23166858_ChIP-Seq_MCF-7_Human0.74985617
169JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74968975
170AR_21572438_ChIP-Seq_LNCaP_Human0.74912884
171ARNT_22903824_ChIP-Seq_MCF-7_Human0.74600782
172LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.74368573
173CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73157604
174SOX2_20726797_ChIP-Seq_SW620_Human0.72759275

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.45714852
2MP0001835_abnormal_antigen_presentation3.80590989
3MP0009278_abnormal_bone_marrow3.41032766
4MP0003303_peritoneal_inflammation3.16434740
5MP0004510_myositis3.11007564
6MP0003172_abnormal_lysosome_physiology3.01790401
7MP0003436_decreased_susceptibility_to3.00134560
8MP0002419_abnormal_innate_immunity2.98414131
9MP0005000_abnormal_immune_tolerance2.85550346
10MP0005058_abnormal_lysosome_morphology2.84217467
11MP0002148_abnormal_hypersensitivity_rea2.57181475
12MP0004947_skin_inflammation2.56524703
13MP0001800_abnormal_humoral_immune2.56060536
14MP0005387_immune_system_phenotype2.53872309
15MP0001790_abnormal_immune_system2.53872309
16MP0002452_abnormal_antigen_presenting2.51186967
17MP0003787_abnormal_imprinting2.50723661
18MP0003183_abnormal_peptide_metabolism2.49276014
19MP0009785_altered_susceptibility_to2.44526393
20MP0005025_abnormal_response_to2.42100865
21MP0002723_abnormal_immune_serum2.36775877
22MP0005174_abnormal_tail_pigmentation2.33902903
23MP0006082_CNS_inflammation2.31951503
24MP0005464_abnormal_platelet_physiology2.23683139
25MP0000685_abnormal_immune_system2.21832868
26MP0002837_dystrophic_cardiac_calcinosis2.19541799
27MP0002139_abnormal_hepatobiliary_system2.15576071
28MP0008875_abnormal_xenobiotic_pharmacok2.04481690
29MP0001819_abnormal_immune_cell1.97459059
30MP0002420_abnormal_adaptive_immunity1.95962720
31MP0008877_abnormal_DNA_methylation1.94077971
32MP0006072_abnormal_retinal_apoptosis1.86153576
33MP0000604_amyloidosis1.85946609
34MP0005646_abnormal_pituitary_gland1.83637825
35MP0005671_abnormal_response_to1.83258442
36MP0003300_gastrointestinal_ulcer1.80160280
37MP0002254_reproductive_system_inflammat1.79858747
38MP0000015_abnormal_ear_pigmentation1.78348658
39MP0003724_increased_susceptibility_to1.73864642
40MP0002876_abnormal_thyroid_physiology1.73830934
41MP0003690_abnormal_glial_cell1.73651592
42MP0001853_heart_inflammation1.71653099
43MP0003646_muscle_fatigue1.68118538
44MP0003448_altered_tumor_morphology1.68019866
45MP0005397_hematopoietic_system_phenotyp1.67675459
46MP0001545_abnormal_hematopoietic_system1.67675459
47MP0009764_decreased_sensitivity_to1.62964985
48MP0009840_abnormal_foam_cell1.56416516
49MP0005551_abnormal_eye_electrophysiolog1.56179126
50MP0001845_abnormal_inflammatory_respons1.48666587
51MP0010386_abnormal_urinary_bladder1.48665365
52MP0008260_abnormal_autophagy1.48566141
53MP0002405_respiratory_system_inflammati1.46922170
54MP0005253_abnormal_eye_physiology1.46724139
55MP0005167_abnormal_blood-brain_barrier1.45861665
56MP0004885_abnormal_endolymph1.42907191
57MP0001533_abnormal_skeleton_physiology1.40640330
58MP0001851_eye_inflammation1.36734820
59MP0008469_abnormal_protein_level1.32691167
60MP0000716_abnormal_immune_system1.30890448
61MP0001968_abnormal_touch/_nociception1.28243794
62MP0002102_abnormal_ear_morphology1.28154286
63MP0002006_tumorigenesis1.25360609
64MP0010155_abnormal_intestine_physiology1.25120710
65MP0003075_altered_response_to1.24472284
66MP0003191_abnormal_cellular_cholesterol1.24297701
67MP0000920_abnormal_myelination1.23736474
68MP0005310_abnormal_salivary_gland1.20320574
69MP0002398_abnormal_bone_marrow1.18693145
70MP0003011_delayed_dark_adaptation1.18159509
71MP0009745_abnormal_behavioral_response1.17772430
72MP0003453_abnormal_keratinocyte_physiol1.17367181
73MP0000371_diluted_coat_color1.16417615
74MP0000689_abnormal_spleen_morphology1.15226807
75MP0003880_abnormal_central_pattern1.11638349
76MP0008872_abnormal_physiological_respon1.09817675
77MP0002272_abnormal_nervous_system1.09483855
78MP0002998_abnormal_bone_remodeling1.07098807
79MP0003091_abnormal_cell_migration1.06337889
80MP0004924_abnormal_behavior1.05611072
81MP0005386_behavior/neurological_phenoty1.05611072
82MP0005647_abnormal_sex_gland1.05572760
83MP0004381_abnormal_hair_follicle1.04557113
84MP0002166_altered_tumor_susceptibility1.04241005
85MP0002138_abnormal_hepatobiliary_system1.03629463
86MP0003828_pulmonary_edema1.02770367
87MP0005365_abnormal_bile_salt1.01930941
88MP0002653_abnormal_ependyma_morphology1.00942705
89MP0009763_increased_sensitivity_to0.98948369
90MP0002693_abnormal_pancreas_physiology0.98368023
91MP0002429_abnormal_blood_cell0.97131527
92MP0001486_abnormal_startle_reflex0.96324212
93MP0001986_abnormal_taste_sensitivity0.95244130
94MP0002009_preneoplasia0.95071438
95MP0000343_altered_response_to0.94907880
96MP0001873_stomach_inflammation0.94251023
97MP0003566_abnormal_cell_adhesion0.93954565
98MP0001958_emphysema0.93872474
99MP0002933_joint_inflammation0.90339308
100MP0004043_abnormal_pH_regulation0.89962209
101MP0000858_altered_metastatic_potential0.89851934
102MP0005076_abnormal_cell_differentiation0.88784639
103MP0002722_abnormal_immune_system0.88599873
104MP0000465_gastrointestinal_hemorrhage0.88238291
105MP0001764_abnormal_homeostasis0.86167128
106MP0009765_abnormal_xenobiotic_induced0.85821579
107MP0001970_abnormal_pain_threshold0.83935545
108MP0001919_abnormal_reproductive_system0.83921301
109MP0005257_abnormal_intraocular_pressure0.83916668
110MP0002735_abnormal_chemical_nociception0.83302817
111MP0008995_early_reproductive_senescence0.81098289
112MP0005166_decreased_susceptibility_to0.80572815
113MP0001984_abnormal_olfaction0.80162859
114MP0002064_seizures0.79824535
115MP0002733_abnormal_thermal_nociception0.78924092
116MP0000249_abnormal_blood_vessel0.78794580
117MP0000372_irregular_coat_pigmentation0.78722798
118MP0002638_abnormal_pupillary_reflex0.77662205
119MP0003634_abnormal_glial_cell0.77181945
120MP0000383_abnormal_hair_follicle0.77160145
121MP0004142_abnormal_muscle_tone0.76869348
122MP0003763_abnormal_thymus_physiology0.75983962
123MP0000230_abnormal_systemic_arterial0.75196446
124MP0001765_abnormal_ion_homeostasis0.74171603
125MP0005379_endocrine/exocrine_gland_phen0.73589372
126MP0002736_abnormal_nociception_after0.73515988
127MP0001485_abnormal_pinna_reflex0.73179929
128MP0004742_abnormal_vestibular_system0.72800471
129MP0002163_abnormal_gland_morphology0.72321184
130MP0003633_abnormal_nervous_system0.71916041
131MP0005164_abnormal_response_to0.71315685
132MP0003252_abnormal_bile_duct0.71268379
133MP0003879_abnormal_hair_cell0.70560691
134MP0003656_abnormal_erythrocyte_physiolo0.69989122
135MP0001440_abnormal_grooming_behavior0.68103516
136MP0002277_abnormal_respiratory_mucosa0.65686851
137MP0005075_abnormal_melanosome_morpholog0.64965563
138MP0005197_abnormal_uvea_morphology0.62218427
139MP0005408_hypopigmentation0.62111839
140MP0001501_abnormal_sleep_pattern0.60664326
141MP0004883_abnormal_blood_vessel0.59985393
142MP0002332_abnormal_exercise_endurance0.59689600
143MP0003195_calcinosis0.55889704
144MP0003866_abnormal_defecation0.55702429
145MP0009333_abnormal_splenocyte_physiolog0.54938019
146MP0002075_abnormal_coat/hair_pigmentati0.54655038
147MP0005390_skeleton_phenotype0.54242760
148MP0010678_abnormal_skin_adnexa0.53164150
149MP0001191_abnormal_skin_condition0.51954506
150MP0002090_abnormal_vision0.50879248
151MP0009046_muscle_twitch0.50773313

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)7.26903847
2Recurrent bacterial skin infections (HP:0005406)7.01378421
3Recurrent abscess formation (HP:0002722)6.95759413
4Elevated erythrocyte sedimentation rate (HP:0003565)6.78095574
5Eczematoid dermatitis (HP:0000976)5.39878995
6Amyloidosis (HP:0011034)5.24064585
7Recurrent gram-negative bacterial infections (HP:0005420)4.81863484
8Mediastinal lymphadenopathy (HP:0100721)4.67460921
9Thick nail (HP:0001805)4.63921706
10Recurrent skin infections (HP:0001581)4.36472236
11Prostate neoplasm (HP:0100787)4.30351395
12Abnormality of macrophages (HP:0004311)4.22656739
13Gingivitis (HP:0000230)3.97665541
14Increased cerebral lipofuscin (HP:0011813)3.95308597
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.71941427
16Vasculitis (HP:0002633)3.66769352
17Retrobulbar optic neuritis (HP:0100654)3.61219029
18Optic neuritis (HP:0100653)3.61219029
19Periodontitis (HP:0000704)3.56215439
20Orchitis (HP:0100796)3.41237422
21Congenital stationary night blindness (HP:0007642)3.36660365
22Hematochezia (HP:0002573)3.36530868
23Leukocytosis (HP:0001974)3.33727834
24Vacuolated lymphocytes (HP:0001922)3.31910899
25Abolished electroretinogram (ERG) (HP:0000550)3.30715409
26Recurrent fungal infections (HP:0002841)3.29420926
27Pancreatic cysts (HP:0001737)3.26122918
28Progressive sensorineural hearing impairment (HP:0000408)3.25641301
29Myositis (HP:0100614)3.14607655
30Progressive hearing impairment (HP:0001730)2.93355471
31Submucous cleft hard palate (HP:0000176)2.90888466
32Urticaria (HP:0001025)2.88749412
33Axonal loss (HP:0003447)2.88162876
34Episodic fever (HP:0001954)2.80824602
35Recurrent cutaneous fungal infections (HP:0011370)2.78033713
36Chronic mucocutaneous candidiasis (HP:0002728)2.78033713
37Premature loss of primary teeth (HP:0006323)2.76808139
38Chronic obstructive pulmonary disease (HP:0006510)2.74726452
39Obstructive lung disease (HP:0006536)2.74726452
40IgG deficiency (HP:0004315)2.74192245
41Pulmonary infiltrates (HP:0002113)2.72936260
42Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.72505410
43Colitis (HP:0002583)2.72454052
44Gingival bleeding (HP:0000225)2.72092167
45Large earlobe (HP:0009748)2.71750153
46Abnormality of liposaccharide metabolism (HP:0010968)2.68820864
47Abnormality of glycosphingolipid metabolism (HP:0004343)2.68820864
48Abnormality of glycolipid metabolism (HP:0010969)2.68820864
49True hermaphroditism (HP:0010459)2.67020080
50Attenuation of retinal blood vessels (HP:0007843)2.66393998
51Pustule (HP:0200039)2.66314342
52Autoimmune thrombocytopenia (HP:0001973)2.64887704
53Recurrent viral infections (HP:0004429)2.62924694
54Abnormal rod and cone electroretinograms (HP:0008323)2.61385699
55Restrictive lung disease (HP:0002091)2.60475212
56Nephronophthisis (HP:0000090)2.60266394
57Pancreatic fibrosis (HP:0100732)2.57854302
58Hypothermia (HP:0002045)2.57408029
59Congenital sensorineural hearing impairment (HP:0008527)2.51920252
60Slow saccadic eye movements (HP:0000514)2.49096094
61Pulmonary artery stenosis (HP:0004415)2.48308637
62Osteomyelitis (HP:0002754)2.46674106
63Systemic lupus erythematosus (HP:0002725)2.42731531
64Cellulitis (HP:0100658)2.39353981
65Agitation (HP:0000713)2.39099839
66Absent rod-and cone-mediated responses on ERG (HP:0007688)2.36667057
67Myocardial infarction (HP:0001658)2.36014957
68Abnormality of eosinophils (HP:0001879)2.32898571
69Abnormality of the renal cortex (HP:0011035)2.29719045
70Type II lissencephaly (HP:0007260)2.24917398
71Pendular nystagmus (HP:0012043)2.23695205
72Abnormality of the renal medulla (HP:0100957)2.23542518
73Gangrene (HP:0100758)2.21807676
74Molar tooth sign on MRI (HP:0002419)2.21603121
75Abnormality of midbrain morphology (HP:0002418)2.21603121
76Turricephaly (HP:0000262)2.21574783
77Joint hemorrhage (HP:0005261)2.20750439
78Alveolar cell carcinoma (HP:0006519)2.20364132
79Bone pain (HP:0002653)2.17812695
80Neoplasm of the tracheobronchial system (HP:0100552)2.15591546
81Abnormality of the prostate (HP:0008775)2.14406112
82Abnormality of T cell number (HP:0011839)2.13459266
83Severe combined immunodeficiency (HP:0004430)2.13242467
84Gastrointestinal stroma tumor (HP:0100723)2.11650032
85Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11246090
86Congenital, generalized hypertrichosis (HP:0004540)2.10348115
873-Methylglutaconic aciduria (HP:0003535)2.10151166
88Decreased circulating renin level (HP:0003351)2.08625271
89Dysostosis multiplex (HP:0000943)2.08602159
90Chronic hepatic failure (HP:0100626)2.08294667
91Peripheral demyelination (HP:0011096)2.06820706
92Eosinophilia (HP:0001880)2.06376792
93Interstitial pulmonary disease (HP:0006530)2.04794139
94Absent frontal sinuses (HP:0002688)2.04505343
95Decreased central vision (HP:0007663)2.02880852
96Polyneuropathy (HP:0001271)2.01940233
97Gaze-evoked nystagmus (HP:0000640)2.01915696
98Glomerulonephritis (HP:0000099)2.01340528
99Recurrent pneumonia (HP:0006532)2.00883724
100Hyperventilation (HP:0002883)1.99806456
101Febrile seizures (HP:0002373)1.97699849
102Arterial thrombosis (HP:0004420)1.97663536
103Progressive cerebellar ataxia (HP:0002073)1.97451407
104Inflammation of the large intestine (HP:0002037)1.97118594
105Furrowed tongue (HP:0000221)1.95682640
106Disproportionate short-trunk short stature (HP:0003521)1.94690811
107Meningitis (HP:0001287)1.92687209
108Anhidrosis (HP:0000970)1.92395883
109Generalized hypopigmentation (HP:0007513)1.91490278
110Conical tooth (HP:0000698)1.91295569
111Widely spaced teeth (HP:0000687)1.88431916
112Parakeratosis (HP:0001036)1.87514834
113T lymphocytopenia (HP:0005403)1.87267975
114Hypophosphatemia (HP:0002148)1.87207738
115Erythroderma (HP:0001019)1.86802016
116Stomach cancer (HP:0012126)1.85822517
117Cystic liver disease (HP:0006706)1.85148076
118Distal lower limb amyotrophy (HP:0008944)1.84782852
119Keratoconjunctivitis sicca (HP:0001097)1.84067186
120Plagiocephaly (HP:0001357)1.83507209
121Abnormality of the frontal sinuses (HP:0002687)1.83100455
122Disinhibition (HP:0000734)1.82958705
123Pathologic fracture (HP:0002756)1.82630564
124Clumsiness (HP:0002312)1.81495506
125Absent speech (HP:0001344)1.81345238
126Renal cortical cysts (HP:0000803)1.81112661
127Bony spicule pigmentary retinopathy (HP:0007737)1.79701806
128Progressive visual loss (HP:0000529)1.79079084
129Abnormality of B cell number (HP:0010975)1.78524738
130Frequent falls (HP:0002359)1.78219897
131Limb hypertonia (HP:0002509)1.77563727
132Long toe (HP:0010511)1.76621781
133Hemoptysis (HP:0002105)1.75505022
134Thyroiditis (HP:0100646)1.75203694
135Supranuclear gaze palsy (HP:0000605)1.75176044
136Arthralgia (HP:0002829)1.74697008
137Albinism (HP:0001022)1.74348140
138Epistaxis (HP:0000421)1.73988830
139Depressed nasal tip (HP:0000437)1.73783679
140Gastrointestinal inflammation (HP:0004386)1.73096197
141Osteolytic defects of the phalanges of the hand (HP:0009771)1.72963308
142Osteolytic defects of the hand bones (HP:0009699)1.72963308
143Medial flaring of the eyebrow (HP:0010747)1.71560889
144Hepatosplenomegaly (HP:0001433)1.71230283
145Polydipsia (HP:0001959)1.71138550
146Abnormal drinking behavior (HP:0030082)1.71138550
147Macular degeneration (HP:0000608)1.70979300
148Keratitis (HP:0000491)1.70958276
149Protruding tongue (HP:0010808)1.70676959
150Hemiparesis (HP:0001269)1.70496719
151Tubular atrophy (HP:0000092)1.70328424
152Adactyly (HP:0009776)1.70258686
153Male pseudohermaphroditism (HP:0000037)1.69820295
154Abnormality of the columella (HP:0009929)1.69732646
155Constricted visual fields (HP:0001133)1.69482094
156Combined immunodeficiency (HP:0005387)1.68754887
157Loss of speech (HP:0002371)1.67517694
158Keratoconjunctivitis (HP:0001096)1.67416406
159Onion bulb formation (HP:0003383)1.67294995
160Pruritus (HP:0000989)1.66205162
161Keratoconus (HP:0000563)1.65071036
162Increased corneal curvature (HP:0100692)1.65071036
163Inability to walk (HP:0002540)1.64987146
164Ketosis (HP:0001946)1.64032924
165Focal seizures (HP:0007359)1.62819836
166Dialeptic seizures (HP:0011146)1.62082950
167Encephalitis (HP:0002383)1.60749285
168Aplasia/hypoplasia of the uterus (HP:0008684)1.58462933
169Photophobia (HP:0000613)1.58429984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.07186014
2MAP3K144.86777982
3RIPK44.34728672
4ADRBK24.27829066
5IRAK34.12336633
6TBK13.32191585
7IRAK43.23974551
8GRK12.97247589
9IKBKE2.89804254
10MAP3K132.78559822
11MAP4K12.69901100
12IKBKB2.53839433
13TYK22.49288635
14MAP4K22.27714913
15TAOK32.05338165
16DAPK22.04836525
17BLK2.04652331
18ACVR1B1.96683817
19CHUK1.91108237
20FES1.89058412
21TLK11.88368820
22KIT1.87302649
23PINK11.86815385
24JAK11.86569483
25TXK1.78907800
26FGR1.76369100
27MAP3K41.66343788
28WNK31.65380447
29CSF1R1.59133406
30EPHB11.57274021
31JAK31.55314549
32SIK21.52397248
33TRIM281.42190937
34HCK1.36095830
35CDK121.33619478
36PKN11.30592172
37CSK1.30336849
38MAP2K21.28593794
39ZAK1.21412266
40MAPK131.19354742
41NUAK11.19039491
42TTN1.13489096
43SYK1.11923229
44TNIK1.09518647
45BMPR1B1.09233145
46INSRR1.08088930
47LCK1.03965034
48BMPR21.03407295
49STK38L1.03105500
50PRPF4B1.01464649
51SIK30.96377135
52CAMKK20.95142235
53GRK60.93824066
54ZAP700.91800416
55LYN0.91619391
56PLK20.91008039
57CAMK1G0.90320248
58JAK20.88218526
59MAPK70.85724818
60TGFBR20.85397397
61PDGFRB0.84437369
62PTK60.79480871
63EGFR0.78595891
64IRAK20.77531355
65STK240.77519866
66MARK30.76591781
67EIF2AK30.75909843
68PIK3CA0.75501633
69ITK0.75162191
70ADRBK10.74340666
71CSNK1G20.74214928
72MAP2K70.73433649
73ERBB40.73170967
74CAMK1D0.72673629
75BCR0.72514313
76PIM10.71925021
77SGK10.71610347
78PRKCQ0.70440640
79YES10.68043881
80DAPK30.67884242
81PBK0.67435586
82CSNK1G30.66756768
83NEK90.64982360
84SGK20.63958328
85EIF2AK20.63641727
86FYN0.62480378
87PHKG20.62286564
88PHKG10.62286564
89SGK2230.60748406
90SGK4940.60748406
91ERBB20.60608617
92MST40.60566976
93NLK0.59820098
94SGK30.58438374
95MATK0.58186151
96GRK70.58102385
97MKNK20.57424691
98CASK0.57332228
99ABL10.57319387
100CSNK1G10.55881837
101MUSK0.55803086
102PDPK10.55713533
103BTK0.54602509
104GSK3A0.54557741
105PAK30.53743592
106IGF1R0.52782913
107PRKCD0.52381646
108MAPKAPK30.51806663
109PRKCG0.51525453
110PDK10.51389951
111ERN10.50772741
112RPS6KA40.50574287
113BCKDK0.50444131
114IRAK10.50157673
115CSNK1A1L0.49882501
116MAP2K60.49038677
117MELK0.48418650
118FER0.47839852
119CDK60.45959281
120BRD40.45652084
121MAP3K100.43945194
122TYRO30.42705492
123TAOK10.39481538
124TNK20.38980905
125TEC0.38501394
126MARK10.38278497
127DAPK10.37887140
128INSR0.37887087
129MAPK100.37579054
130CSNK1A10.37465970
131MAPK150.36685830
132FGFR20.35126318
133PRKCE0.34809524
134PDK20.34362213
135CAMK2A0.33881174
136MAP3K90.33846651
137STK100.33441922
138MAP3K50.32970265
139FGFR30.32550547
140CLK10.31231292
141EPHA30.30689444
142MAPK120.29934359
143ERBB30.29877837
144BMX0.29814649
145STK390.29111286
146EPHA40.28784055
147TRPM70.28281665
148OXSR10.27973676
149RPS6KA60.27505215
150SIK10.27467003
151MAPKAPK20.27227274

Predicted pathways (KEGG)

RankGene SetZ-score
1NOD-like receptor signaling pathway_Homo sapiens_hsa046213.14275712
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.74398958
3Leishmaniasis_Homo sapiens_hsa051402.73914947
4Osteoclast differentiation_Homo sapiens_hsa043802.63198964
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.62321471
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.52534288
7B cell receptor signaling pathway_Homo sapiens_hsa046622.44726185
8Graft-versus-host disease_Homo sapiens_hsa053322.41545825
9Pertussis_Homo sapiens_hsa051332.29648530
10Staphylococcus aureus infection_Homo sapiens_hsa051502.25198426
11Rheumatoid arthritis_Homo sapiens_hsa053232.22347019
12Phototransduction_Homo sapiens_hsa047442.15916522
13Malaria_Homo sapiens_hsa051442.10283984
14TNF signaling pathway_Homo sapiens_hsa046682.02647878
15Tuberculosis_Homo sapiens_hsa051522.02323318
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.96373761
17Legionellosis_Homo sapiens_hsa051341.79978990
18Allograft rejection_Homo sapiens_hsa053301.78715317
19African trypanosomiasis_Homo sapiens_hsa051431.76619503
20Linoleic acid metabolism_Homo sapiens_hsa005911.75436495
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74003838
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.72544433
23Influenza A_Homo sapiens_hsa051641.69113152
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.65521929
25Measles_Homo sapiens_hsa051621.63486184
26Phagosome_Homo sapiens_hsa041451.60210179
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57988477
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56472521
29Tryptophan metabolism_Homo sapiens_hsa003801.55732600
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49755134
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.49754609
32Lysosome_Homo sapiens_hsa041421.48349316
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47196630
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46100748
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45006894
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44752206
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.43973119
38Apoptosis_Homo sapiens_hsa042101.43248382
39Hematopoietic cell lineage_Homo sapiens_hsa046401.38955217
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37848912
41Type II diabetes mellitus_Homo sapiens_hsa049301.37121913
42Toxoplasmosis_Homo sapiens_hsa051451.36886132
43T cell receptor signaling pathway_Homo sapiens_hsa046601.35056394
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32934045
45Asthma_Homo sapiens_hsa053101.32728145
46Chemokine signaling pathway_Homo sapiens_hsa040621.32262238
47Nicotine addiction_Homo sapiens_hsa050331.30388816
48Shigellosis_Homo sapiens_hsa051311.29896819
49Type I diabetes mellitus_Homo sapiens_hsa049401.29417345
50Collecting duct acid secretion_Homo sapiens_hsa049661.28378858
51Salmonella infection_Homo sapiens_hsa051321.24322010
52Hepatitis C_Homo sapiens_hsa051601.17938543
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11011806
54Sulfur metabolism_Homo sapiens_hsa009201.05760153
55Caffeine metabolism_Homo sapiens_hsa002321.05616804
56Primary bile acid biosynthesis_Homo sapiens_hsa001201.05489445
57Nitrogen metabolism_Homo sapiens_hsa009101.03055868
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01507740
59Intestinal immune network for IgA production_Homo sapiens_hsa046721.00341043
60Protein export_Homo sapiens_hsa030600.97937838
61Hepatitis B_Homo sapiens_hsa051610.97448032
62Chronic myeloid leukemia_Homo sapiens_hsa052200.95664367
63Butanoate metabolism_Homo sapiens_hsa006500.93624518
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.89701238
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89439330
66Chemical carcinogenesis_Homo sapiens_hsa052040.89309485
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.88897426
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.87803255
69Arachidonic acid metabolism_Homo sapiens_hsa005900.87699460
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.87622274
71Morphine addiction_Homo sapiens_hsa050320.84528180
72ABC transporters_Homo sapiens_hsa020100.84287669
73Amoebiasis_Homo sapiens_hsa051460.82991378
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.81273051
75Acute myeloid leukemia_Homo sapiens_hsa052210.80930040
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80851503
77Retinol metabolism_Homo sapiens_hsa008300.79654390
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.79362226
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79134569
80Herpes simplex infection_Homo sapiens_hsa051680.78493380
81Taste transduction_Homo sapiens_hsa047420.78139888
82Pancreatic cancer_Homo sapiens_hsa052120.77310306
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75594148
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.74812999
85Steroid biosynthesis_Homo sapiens_hsa001000.74659473
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74124215
87Other glycan degradation_Homo sapiens_hsa005110.72502236
88Complement and coagulation cascades_Homo sapiens_hsa046100.71169966
89Serotonergic synapse_Homo sapiens_hsa047260.71062107
90Platelet activation_Homo sapiens_hsa046110.69112764
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67507224
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65940606
93Viral myocarditis_Homo sapiens_hsa054160.65418787
94Dorso-ventral axis formation_Homo sapiens_hsa043200.64660963
95Ovarian steroidogenesis_Homo sapiens_hsa049130.64095678
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63415373
97Olfactory transduction_Homo sapiens_hsa047400.63172477
98Salivary secretion_Homo sapiens_hsa049700.62272709
99Mineral absorption_Homo sapiens_hsa049780.62023180
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61875208
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61143644
102Prolactin signaling pathway_Homo sapiens_hsa049170.60966529
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60746282
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59515365
105Small cell lung cancer_Homo sapiens_hsa052220.59511637
106Basal transcription factors_Homo sapiens_hsa030220.58821009
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58516548
108MicroRNAs in cancer_Homo sapiens_hsa052060.58076047
109Regulation of autophagy_Homo sapiens_hsa041400.57174332
110Insulin resistance_Homo sapiens_hsa049310.56951482
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56722941
112Oxidative phosphorylation_Homo sapiens_hsa001900.56710137
113Sphingolipid metabolism_Homo sapiens_hsa006000.56529325
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.56362044
115VEGF signaling pathway_Homo sapiens_hsa043700.56161038
116Antigen processing and presentation_Homo sapiens_hsa046120.55390085
117Insulin secretion_Homo sapiens_hsa049110.54348953
118Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53361968
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53272010
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52711430
121Inositol phosphate metabolism_Homo sapiens_hsa005620.51121268
122Synaptic vesicle cycle_Homo sapiens_hsa047210.51029969
123GABAergic synapse_Homo sapiens_hsa047270.50853095
124Autoimmune thyroid disease_Homo sapiens_hsa053200.50370160
125Epstein-Barr virus infection_Homo sapiens_hsa051690.48834668
126Renin secretion_Homo sapiens_hsa049240.48572985
127Primary immunodeficiency_Homo sapiens_hsa053400.48569913
128Circadian rhythm_Homo sapiens_hsa047100.48392723
129Renal cell carcinoma_Homo sapiens_hsa052110.47409859
130Circadian entrainment_Homo sapiens_hsa047130.47096978
131Choline metabolism in cancer_Homo sapiens_hsa052310.46573786
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46258047
133Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45951768
134Glycerolipid metabolism_Homo sapiens_hsa005610.45939717
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44431534
136Proteoglycans in cancer_Homo sapiens_hsa052050.44161384
137Glioma_Homo sapiens_hsa052140.43901223
138Histidine metabolism_Homo sapiens_hsa003400.43321039
139FoxO signaling pathway_Homo sapiens_hsa040680.42287279
140mTOR signaling pathway_Homo sapiens_hsa041500.41373681
141MAPK signaling pathway_Homo sapiens_hsa040100.41176209
142Prion diseases_Homo sapiens_hsa050200.40193686
143Ether lipid metabolism_Homo sapiens_hsa005650.39588410
144Endocytosis_Homo sapiens_hsa041440.38666182
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38127239
146ErbB signaling pathway_Homo sapiens_hsa040120.36727362
147Glutamatergic synapse_Homo sapiens_hsa047240.36102974
148Cholinergic synapse_Homo sapiens_hsa047250.35902660
149Non-small cell lung cancer_Homo sapiens_hsa052230.34662424
150Vibrio cholerae infection_Homo sapiens_hsa051100.32266588

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