RASGEF1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.88541255
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.83462272
3vocalization behavior (GO:0071625)5.76464163
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.71832006
5synaptic vesicle exocytosis (GO:0016079)5.67678068
6synaptic vesicle maturation (GO:0016188)5.59314564
7glutamate secretion (GO:0014047)5.46156874
8neuron cell-cell adhesion (GO:0007158)5.29304258
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.25781668
10regulation of glutamate receptor signaling pathway (GO:1900449)5.17989883
11regulation of synaptic vesicle exocytosis (GO:2000300)5.15678299
12protein localization to synapse (GO:0035418)5.13603603
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.04852295
14locomotory exploration behavior (GO:0035641)4.90478272
15neuronal ion channel clustering (GO:0045161)4.85321265
16neuronal action potential propagation (GO:0019227)4.64721668
17negative regulation of inclusion body assembly (GO:0090084)4.64612130
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.60828315
19layer formation in cerebral cortex (GO:0021819)4.58909319
20neurotransmitter secretion (GO:0007269)4.52414683
21establishment of mitochondrion localization (GO:0051654)4.46733548
22neurotransmitter-gated ion channel clustering (GO:0072578)4.44470209
23regulation of synapse structural plasticity (GO:0051823)4.43643297
24regulation of synaptic vesicle transport (GO:1902803)4.37717211
25sodium ion export (GO:0071436)4.29914580
26dendritic spine morphogenesis (GO:0060997)4.17403287
27regulation of neuronal synaptic plasticity (GO:0048168)4.12267805
28mitochondrion transport along microtubule (GO:0047497)4.08703042
29establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.08703042
30regulation of long-term neuronal synaptic plasticity (GO:0048169)4.06300021
31exploration behavior (GO:0035640)4.05985298
32ionotropic glutamate receptor signaling pathway (GO:0035235)4.03971283
33glutamate receptor signaling pathway (GO:0007215)4.02643807
34postsynaptic membrane organization (GO:0001941)4.02505302
35presynaptic membrane assembly (GO:0097105)3.99149125
36regulation of dendritic spine morphogenesis (GO:0061001)3.96701385
37positive regulation of synapse maturation (GO:0090129)3.96213416
38neuron-neuron synaptic transmission (GO:0007270)3.94203608
39presynaptic membrane organization (GO:0097090)3.87951722
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.87538792
41synaptic transmission, glutamatergic (GO:0035249)3.84103687
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.84037889
43prepulse inhibition (GO:0060134)3.81366102
44positive regulation of neurotransmitter secretion (GO:0001956)3.77378256
45positive regulation of membrane potential (GO:0045838)3.75137003
46regulation of inclusion body assembly (GO:0090083)3.74935165
47axon ensheathment in central nervous system (GO:0032291)3.72887446
48central nervous system myelination (GO:0022010)3.72887446
49cellular response to arsenic-containing substance (GO:0071243)3.72805389
50regulation of postsynaptic membrane potential (GO:0060078)3.69411196
51positive regulation of neurotransmitter transport (GO:0051590)3.69003121
52gamma-aminobutyric acid signaling pathway (GO:0007214)3.65006850
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64198141
54auditory behavior (GO:0031223)3.63183686
55regulation of neurotransmitter secretion (GO:0046928)3.61864034
56neurotransmitter transport (GO:0006836)3.61657882
57neuron recognition (GO:0008038)3.61324589
58proline transport (GO:0015824)3.59352719
59positive regulation of dendritic spine morphogenesis (GO:0061003)3.58475445
60long-term memory (GO:0007616)3.56419604
61response to histamine (GO:0034776)3.53457843
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.51837174
63neurofilament cytoskeleton organization (GO:0060052)3.50862090
64long-term synaptic potentiation (GO:0060291)3.50181501
65L-amino acid import (GO:0043092)3.46415239
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.45872541
67regulation of neurotransmitter transport (GO:0051588)3.44141100
68cell-cell junction maintenance (GO:0045217)3.43985305
69amino acid import (GO:0043090)3.43299484
70synaptic vesicle endocytosis (GO:0048488)3.42954947
71regulation of dendritic spine development (GO:0060998)3.42941615
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.42794394
73dendritic spine organization (GO:0097061)3.42389275
74G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.42055175
75transmission of nerve impulse (GO:0019226)3.41495133
76activation of protein kinase A activity (GO:0034199)3.41350887
77regulation of neurotransmitter levels (GO:0001505)3.39678634
78regulation of vesicle fusion (GO:0031338)3.38923616
79regulation of synaptic plasticity (GO:0048167)3.37510195
80gamma-aminobutyric acid transport (GO:0015812)3.35202402
81regulation of voltage-gated calcium channel activity (GO:1901385)3.34040051
82cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.30778381
83positive regulation of synaptic transmission, GABAergic (GO:0032230)3.30081768
84behavioral response to cocaine (GO:0048148)3.29866932
85positive regulation of dendritic spine development (GO:0060999)3.29506214
86synapse assembly (GO:0007416)3.27963686
87potassium ion import (GO:0010107)3.27068484
88membrane depolarization (GO:0051899)3.25627699
89axonal fasciculation (GO:0007413)3.24777453
90membrane hyperpolarization (GO:0060081)3.24651448
91pyrimidine nucleobase catabolic process (GO:0006208)3.22083836
92regulation of ARF protein signal transduction (GO:0032012)3.21871454
93response to auditory stimulus (GO:0010996)3.21215860
94protein refolding (GO:0042026)3.20444140
95neuromuscular process controlling balance (GO:0050885)3.19263836
96cerebellar Purkinje cell layer development (GO:0021680)3.19004397
97negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18488514
98membrane depolarization during action potential (GO:0086010)3.18409612
99cerebellar Purkinje cell differentiation (GO:0021702)3.17164683
100dendrite morphogenesis (GO:0048813)3.15814907
101regulation of glutamate secretion (GO:0014048)3.13845734
102cellular potassium ion homeostasis (GO:0030007)3.12436240
103mechanosensory behavior (GO:0007638)3.11379482
104potassium ion homeostasis (GO:0055075)3.09655234
105adult walking behavior (GO:0007628)3.07294891
106mating behavior (GO:0007617)3.06428572
107positive regulation of synaptic transmission (GO:0050806)3.06180983
108cell migration in hindbrain (GO:0021535)3.05286352
109striatum development (GO:0021756)3.05100219
110learning (GO:0007612)3.04666236
111cerebellar granule cell differentiation (GO:0021707)3.03514986
112positive regulation of synapse assembly (GO:0051965)3.02337901
113positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00848415
114synapse organization (GO:0050808)3.00685298
115regulation of synapse maturation (GO:0090128)3.00079866
116synaptic transmission (GO:0007268)2.98273805
117regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.96952036
118glycine transport (GO:0015816)2.95810726
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.94863771
120establishment of planar polarity (GO:0001736)2.94389370
121establishment of tissue polarity (GO:0007164)2.94389370
122negative regulation of dendrite morphogenesis (GO:0050774)2.92793409
123regulation of synaptic transmission (GO:0050804)2.91643032
124positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89373228
125intraspecies interaction between organisms (GO:0051703)2.89028557
126social behavior (GO:0035176)2.89028557
127innervation (GO:0060384)2.88932708
128cell communication by electrical coupling (GO:0010644)2.88802439
129behavioral response to nicotine (GO:0035095)2.87015913
130adenosine receptor signaling pathway (GO:0001973)2.85923160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.42537974
2GBX2_23144817_ChIP-Seq_PC3_Human4.01951965
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.41732806
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.31517240
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.27653602
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09243183
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.91404001
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.83475718
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83415140
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83415140
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.79017381
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.72325013
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68732321
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.68691474
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57823685
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57466742
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57403961
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56117828
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.54272469
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.46414347
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.46135972
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.44078370
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40999170
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.40270207
25DROSHA_22980978_ChIP-Seq_HELA_Human2.39271473
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.34904589
27AR_21572438_ChIP-Seq_LNCaP_Human2.31525463
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.24824880
29TAF15_26573619_Chip-Seq_HEK293_Human2.07732578
30CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07029015
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83339826
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79641101
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77131977
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74711034
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73618693
36RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.72635802
37* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.70044655
38* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.66207417
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65837109
40* LXR_22292898_ChIP-Seq_THP-1_Human1.65235890
41SMAD4_21799915_ChIP-Seq_A2780_Human1.64030827
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63513955
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.62452873
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61636340
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53082363
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43972586
47SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.43589645
48P300_19829295_ChIP-Seq_ESCs_Human1.43494440
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43184927
50OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.43136403
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42046371
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.40397197
53* RING1B_27294783_Chip-Seq_ESCs_Mouse1.40192601
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38234032
55ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38134555
56TET1_21490601_ChIP-Seq_MESCs_Mouse1.37367973
57CTCF_27219007_Chip-Seq_Bcells_Human1.36977156
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35559630
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.35522188
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35512170
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.34483640
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33946233
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33063251
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32770032
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.32302574
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.32297492
67SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29292051
68AR_25329375_ChIP-Seq_VCAP_Human1.25372789
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25166757
70* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24966168
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23740178
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23223264
73RNF2_27304074_Chip-Seq_NSC_Mouse1.22399743
74TP53_20018659_ChIP-ChIP_R1E_Mouse1.22305221
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19973394
76CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.17417704
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17319454
78KDM2B_26808549_Chip-Seq_DND41_Human1.17275270
79SMC4_20622854_ChIP-Seq_HELA_Human1.16753740
80STAT3_23295773_ChIP-Seq_U87_Human1.16382950
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.14257243
82OCT4_19829295_ChIP-Seq_ESCs_Human1.12897357
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12316324
84* AR_19668381_ChIP-Seq_PC3_Human1.12028460
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11432215
86* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08776323
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08764768
88TCF4_23295773_ChIP-Seq_U87_Human1.08676204
89TET1_21451524_ChIP-Seq_MESCs_Mouse1.08648556
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08547685
91PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08499954
92* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07661263
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06068255
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05948557
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.05344748
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03043482
97ZNF274_21170338_ChIP-Seq_K562_Hela1.01500202
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.01069865
99P68_20966046_ChIP-Seq_HELA_Human1.00894505
100DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00630481
101SMAD_19615063_ChIP-ChIP_OVARY_Human1.00599041
102AHR_22903824_ChIP-Seq_MCF-7_Human1.00596237
103TP53_16413492_ChIP-PET_HCT116_Human1.00408946
104RUNX2_22187159_ChIP-Seq_PCA_Human0.98901483
105PRDM14_20953172_ChIP-Seq_ESCs_Human0.98519384
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98325683
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98197824
108SMAD3_21741376_ChIP-Seq_ESCs_Human0.97834859
109FUS_26573619_Chip-Seq_HEK293_Human0.97649726
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97130464
111ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96101087
112KDM2B_26808549_Chip-Seq_K562_Human0.95642043
113ELF1_20517297_ChIP-Seq_JURKAT_Human0.93907008
114KLF4_19829295_ChIP-Seq_ESCs_Human0.93886689
115CREB1_26743006_Chip-Seq_LNCaP_Human0.93558566
116JUN_21703547_ChIP-Seq_K562_Human0.93495269
117* GATA1_26923725_Chip-Seq_HPCs_Mouse0.92978281
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91897492
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91433002
120SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.90904803
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89595952
122NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89540276
123MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89197691
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89036390
125ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87867993
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87708255
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87651087
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87357187
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87357187
130SA1_27219007_Chip-Seq_ERYTHROID_Human0.86826014
131SMAD4_21741376_ChIP-Seq_HESCs_Human0.86517762
132* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85486366
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85461241
134KDM2B_26808549_Chip-Seq_REH_Human0.85231642
135VDR_22108803_ChIP-Seq_LS180_Human0.85115075
136* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.85071935
137NANOG_18555785_Chip-Seq_ESCs_Mouse0.84531370
138VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84324389
139CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81808266
140YY1_21170310_ChIP-Seq_MESCs_Mouse0.80715200
141TRIM28_21343339_ChIP-Seq_HEK293_Human0.80455591
142TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.79590083
143RUNX1_26923725_Chip-Seq_HPCs_Mouse0.77457841
144CTCF_20526341_ChIP-Seq_ESCs_Human0.77250557
145CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76071103
146SA1_27219007_Chip-Seq_Bcells_Human0.75093088
147BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.74502080
148SOX3_22085726_ChIP-Seq_NPCs_Mouse0.74321589
149TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73467800
150THAP11_20581084_ChIP-Seq_MESCs_Mouse0.73465792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.88028875
2MP0003880_abnormal_central_pattern4.99486658
3MP0003635_abnormal_synaptic_transmissio4.08955679
4MP0004270_analgesia3.64061154
5MP0001968_abnormal_touch/_nociception3.48156969
6MP0009745_abnormal_behavioral_response3.46496867
7MP0002063_abnormal_learning/memory/cond3.34057305
8MP0009046_muscle_twitch3.23863594
9MP0002064_seizures3.18847857
10MP0002822_catalepsy2.99364596
11MP0005423_abnormal_somatic_nervous2.84351392
12MP0002572_abnormal_emotion/affect_behav2.78544558
13MP0002734_abnormal_mechanical_nocicepti2.73630451
14MP0001486_abnormal_startle_reflex2.70970652
15MP0002736_abnormal_nociception_after2.65369673
16MP0002272_abnormal_nervous_system2.58861542
17MP0002067_abnormal_sensory_capabilities2.10646024
18MP0001529_abnormal_vocalization2.08692963
19MP0001440_abnormal_grooming_behavior2.08250378
20MP0002735_abnormal_chemical_nociception2.04617074
21MP0002733_abnormal_thermal_nociception2.00843742
22MP0002184_abnormal_innervation1.97876387
23MP0001970_abnormal_pain_threshold1.95618485
24MP0000778_abnormal_nervous_system1.89552990
25MP0001501_abnormal_sleep_pattern1.88271262
26MP0005386_behavior/neurological_phenoty1.86641727
27MP0004924_abnormal_behavior1.86641727
28MP0004811_abnormal_neuron_physiology1.85249669
29MP0002557_abnormal_social/conspecific_i1.83952416
30MP0008569_lethality_at_weaning1.79767708
31MP0001984_abnormal_olfaction1.73997287
32MP0009780_abnormal_chondrocyte_physiolo1.70916092
33MP0004858_abnormal_nervous_system1.70792250
34MP0000955_abnormal_spinal_cord1.69953397
35MP0003879_abnormal_hair_cell1.67789108
36MP0002909_abnormal_adrenal_gland1.60188671
37MP0003329_amyloid_beta_deposits1.55812921
38MP0004142_abnormal_muscle_tone1.50486437
39MP0002882_abnormal_neuron_morphology1.49208224
40MP0001905_abnormal_dopamine_level1.48572492
41MP0000751_myopathy1.43976067
42MP0002638_abnormal_pupillary_reflex1.43885327
43MP0002066_abnormal_motor_capabilities/c1.43465701
44MP0001188_hyperpigmentation1.42071183
45MP0003633_abnormal_nervous_system1.37801990
46MP0006276_abnormal_autonomic_nervous1.36957258
47MP0005646_abnormal_pituitary_gland1.34467067
48MP0003122_maternal_imprinting1.21313425
49MP0005645_abnormal_hypothalamus_physiol1.21085712
50MP0002152_abnormal_brain_morphology1.19607562
51MP0003631_nervous_system_phenotype1.18214351
52MP0005551_abnormal_eye_electrophysiolog1.17386816
53MP0000631_abnormal_neuroendocrine_gland1.15420515
54MP0003172_abnormal_lysosome_physiology1.13429700
55MP0008872_abnormal_physiological_respon1.11653819
56MP0010386_abnormal_urinary_bladder1.10067489
57MP0003787_abnormal_imprinting1.08203230
58MP0001502_abnormal_circadian_rhythm1.06377246
59MP0004885_abnormal_endolymph1.05558227
60MP0002090_abnormal_vision1.03046107
61MP0004145_abnormal_muscle_electrophysio1.02887050
62MP0002069_abnormal_eating/drinking_beha0.98380420
63MP0005623_abnormal_meninges_morphology0.97383392
64MP0003634_abnormal_glial_cell0.97315199
65MP0002229_neurodegeneration0.97109282
66MP0001348_abnormal_lacrimal_gland0.95632023
67MP0000920_abnormal_myelination0.94071188
68MP0001346_abnormal_lacrimal_gland0.91121483
69MP0008961_abnormal_basal_metabolism0.90818285
70MP0002752_abnormal_somatic_nervous0.90512470
71MP0006072_abnormal_retinal_apoptosis0.90218193
72MP0005409_darkened_coat_color0.89873587
73MP0004742_abnormal_vestibular_system0.89566565
74MP0000026_abnormal_inner_ear0.85924506
75MP0008874_decreased_physiological_sensi0.85103094
76MP0003123_paternal_imprinting0.84783260
77MP0002837_dystrophic_cardiac_calcinosis0.84671045
78MP0001963_abnormal_hearing_physiology0.83656234
79MP0005499_abnormal_olfactory_system0.83016720
80MP0005394_taste/olfaction_phenotype0.83016720
81MP0003137_abnormal_impulse_conducting0.81611599
82MP0005535_abnormal_body_temperature0.80385120
83MP0004085_abnormal_heartbeat0.79366086
84MP0002751_abnormal_autonomic_nervous0.79197959
85MP0003632_abnormal_nervous_system0.74886338
86MP0001177_atelectasis0.74818885
87MP0001485_abnormal_pinna_reflex0.74460197
88MP0000604_amyloidosis0.74320779
89MP0003690_abnormal_glial_cell0.72869336
90MP0008877_abnormal_DNA_methylation0.71941137
91MP0003861_abnormal_nervous_system0.71626183
92MP0009840_abnormal_foam_cell0.69402170
93MP0001664_abnormal_digestion0.67338343
94MP0004215_abnormal_myocardial_fiber0.65762102
95MP0000343_altered_response_to0.64745515
96MP0000566_synostosis0.64359268
97MP0000747_muscle_weakness0.64121830
98MP0003075_altered_response_to0.60931095
99MP0001943_abnormal_respiration0.60239418
100MP0004233_abnormal_muscle_weight0.59925529
101MP0002249_abnormal_larynx_morphology0.58987433
102MP0010770_preweaning_lethality0.58528517
103MP0002082_postnatal_lethality0.58528517
104MP0010769_abnormal_survival0.58101389
105MP0005253_abnormal_eye_physiology0.57064754
106MP0009672_abnormal_birth_weight0.56963197
107MP0004043_abnormal_pH_regulation0.56168523
108MP0002653_abnormal_ependyma_morphology0.55124693
109MP0010768_mortality/aging0.54349780
110MP0003938_abnormal_ear_development0.54003009
111MP0003283_abnormal_digestive_organ0.53888489
112MP0000013_abnormal_adipose_tissue0.53673836
113MP0001986_abnormal_taste_sensitivity0.53639344
114MP0000537_abnormal_urethra_morphology0.53554369
115MP0005167_abnormal_blood-brain_barrier0.51387254
116MP0003956_abnormal_body_size0.51111424
117MP0002160_abnormal_reproductive_system0.51008131
118MP0004484_altered_response_of0.50876259
119MP0000639_abnormal_adrenal_gland0.50756117
120MP0005248_abnormal_Harderian_gland0.50589195
121MP0002081_perinatal_lethality0.49430000
122MP0000681_abnormal_thyroid_gland0.48866843

Predicted human phenotypes

RankGene SetZ-score
1Nuclear cataract (HP:0100018)8.75068801
2Focal motor seizures (HP:0011153)7.09935491
3Myokymia (HP:0002411)6.79508288
4Focal seizures (HP:0007359)5.63521993
5Epileptic encephalopathy (HP:0200134)5.21969196
6Visual hallucinations (HP:0002367)4.79242743
7Febrile seizures (HP:0002373)4.62149566
8Atonic seizures (HP:0010819)4.37225905
9Zonular cataract (HP:0010920)3.97858435
10Action tremor (HP:0002345)3.94721704
11Ankle clonus (HP:0011448)3.94716819
12Absence seizures (HP:0002121)3.94372382
13Insidious onset (HP:0003587)3.92480093
14Termporal pattern (HP:0011008)3.92480093
15Decreased circulating renin level (HP:0003351)3.91054987
16Progressive cerebellar ataxia (HP:0002073)3.83774767
17Dialeptic seizures (HP:0011146)3.71220013
18Hyperactive renin-angiotensin system (HP:0000841)3.62663126
19Generalized tonic-clonic seizures (HP:0002069)3.59773267
20Poor eye contact (HP:0000817)3.51744757
21Broad-based gait (HP:0002136)3.43537771
22Hypokalemic alkalosis (HP:0001949)3.37928672
23Axonal loss (HP:0003447)3.35945701
24Impaired vibration sensation in the lower limbs (HP:0002166)3.29423758
25Papilledema (HP:0001085)3.27078326
26Urinary bladder sphincter dysfunction (HP:0002839)3.25894102
27Limb dystonia (HP:0002451)3.22312142
28Supranuclear gaze palsy (HP:0000605)3.20765486
29Abnormality of the corticospinal tract (HP:0002492)3.20615444
30Depression (HP:0000716)3.18011028
31Amblyopia (HP:0000646)3.13538467
32Hyperventilation (HP:0002883)3.12970193
33Peripheral hypomyelination (HP:0007182)3.07880213
34Torticollis (HP:0000473)3.06746326
35Hemiparesis (HP:0001269)2.96903139
36Abnormal social behavior (HP:0012433)2.95987534
37Impaired social interactions (HP:0000735)2.95987534
38Gaze-evoked nystagmus (HP:0000640)2.88917951
39Hand muscle atrophy (HP:0009130)2.87990857
40Spastic gait (HP:0002064)2.84832729
41Anxiety (HP:0000739)2.83693242
42Neuronal loss in central nervous system (HP:0002529)2.81751249
43Urinary urgency (HP:0000012)2.79986084
44Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.78740996
45Degeneration of the lateral corticospinal tracts (HP:0002314)2.78740996
46Abnormal eating behavior (HP:0100738)2.78461712
47Dysdiadochokinesis (HP:0002075)2.77085047
48Mutism (HP:0002300)2.72760572
49Truncal ataxia (HP:0002078)2.65310800
50Ulnar claw (HP:0001178)2.61861729
51Focal dystonia (HP:0004373)2.61561067
52Hyperkalemia (HP:0002153)2.57396035
53Dysmetria (HP:0001310)2.56513415
54Distal upper limb amyotrophy (HP:0007149)2.54278159
55Upper limb amyotrophy (HP:0009129)2.54278159
56Craniofacial dystonia (HP:0012179)2.51847456
57Drooling (HP:0002307)2.50811257
58Excessive salivation (HP:0003781)2.50811257
59Impaired smooth pursuit (HP:0007772)2.50001627
60Renal salt wasting (HP:0000127)2.47923701
61Postural instability (HP:0002172)2.44126210
62Chronic bronchitis (HP:0004469)2.43977615
63Bradykinesia (HP:0002067)2.42808540
64Epileptiform EEG discharges (HP:0011182)2.42407020
65Congenital stationary night blindness (HP:0007642)2.42051977
66Cerebral hypomyelination (HP:0006808)2.41407358
67Lower limb muscle weakness (HP:0007340)2.41212586
68Lower limb amyotrophy (HP:0007210)2.40353027
69Foot dorsiflexor weakness (HP:0009027)2.38173321
70Hyperaldosteronism (HP:0000859)2.35946645
71Diaphragmatic weakness (HP:0009113)2.35413836
72Stereotypic behavior (HP:0000733)2.34593089
73Abnormality of the lower motor neuron (HP:0002366)2.33604352
74Rapidly progressive (HP:0003678)2.33148591
75EEG with generalized epileptiform discharges (HP:0011198)2.31822412
76Polyphagia (HP:0002591)2.29947329
77Hypoventilation (HP:0002791)2.29451597
78Apathy (HP:0000741)2.28357135
79Impaired vibratory sensation (HP:0002495)2.26830480
80Status epilepticus (HP:0002133)2.25868776
81Cerebral inclusion bodies (HP:0100314)2.25776889
82Tetraplegia (HP:0002445)2.24385758
83Genetic anticipation (HP:0003743)2.22110627
84Athetosis (HP:0002305)2.21387067
85Neurofibrillary tangles (HP:0002185)2.20090712
86Pheochromocytoma (HP:0002666)2.18806947
87Upper limb muscle weakness (HP:0003484)2.17806277
88Postural tremor (HP:0002174)2.17108238
89Hypsarrhythmia (HP:0002521)2.15799297
90Generalized myoclonic seizures (HP:0002123)2.13900486
91Abnormality of the foot musculature (HP:0001436)2.13462141
92Dysmetric saccades (HP:0000641)2.12273916
93Clonus (HP:0002169)2.11981895
94Abnormality of renin-angiotensin system (HP:0000847)2.11540505
95Scanning speech (HP:0002168)2.10219122
96Insomnia (HP:0100785)2.08428626
97Fetal akinesia sequence (HP:0001989)2.08076903
98Progressive inability to walk (HP:0002505)2.05460972
99Akinesia (HP:0002304)2.04384587
100Rigidity (HP:0002063)2.03761871
101Annular pancreas (HP:0001734)2.02560766
102Inability to walk (HP:0002540)2.01039552
103Abnormality of ocular smooth pursuit (HP:0000617)1.99105911
104Distal sensory impairment (HP:0002936)1.98898885
105Diminished motivation (HP:0000745)1.97683904
106Hyperthyroidism (HP:0000836)1.97441035
107Agitation (HP:0000713)1.96312157
108Megalencephaly (HP:0001355)1.95518939
109Resting tremor (HP:0002322)1.95000047
110Delusions (HP:0000746)1.94756680
111Amyotrophic lateral sclerosis (HP:0007354)1.93207261
112Esotropia (HP:0000565)1.92847270
113Intention tremor (HP:0002080)1.92785682
114Incomplete penetrance (HP:0003829)1.91183128
115Hemiplegia (HP:0002301)1.90893521
116Diminished movement (HP:0002374)1.90864332
117Diplopia (HP:0000651)1.89313069
118Abnormality of binocular vision (HP:0011514)1.89313069
119Morphological abnormality of the pyramidal tract (HP:0002062)1.88840531
120Absent speech (HP:0001344)1.87646642
121Protruding tongue (HP:0010808)1.87201188
122Neuroendocrine neoplasm (HP:0100634)1.85580056
123Sleep apnea (HP:0010535)1.85010955
124Onion bulb formation (HP:0003383)1.82487474
125Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.79205925
126Neoplasm of the peripheral nervous system (HP:0100007)1.77736722
127Atrophy/Degeneration involving motor neurons (HP:0007373)1.77661707
128Hypokinesia (HP:0002375)1.77005927
129Adrenal overactivity (HP:0002717)1.76264787
130Specific learning disability (HP:0001328)1.75676692
131Dementia (HP:0000726)1.75105240
132Poor suck (HP:0002033)1.72832866
133Choreoathetosis (HP:0001266)1.72556356
134Obstructive sleep apnea (HP:0002870)1.72101838
135Abnormality of the periventricular white matter (HP:0002518)1.71496616
136Hammertoe (HP:0001765)1.70745935

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.02424706
2MAP3K93.80184997
3NTRK33.72643488
4MARK13.50509356
5DAPK23.47567585
6MAP3K43.45543743
7MAP2K73.07139242
8CCNB12.71087015
9CASK2.66978429
10MINK12.34817403
11PAK62.32618820
12DAPK12.17439172
13MAP2K42.08553148
14NTRK22.06486371
15CAMKK11.97558380
16MAP3K121.89490704
17PLK21.85199680
18TSSK61.79037457
19TAOK31.74355641
20KSR21.74331739
21RIPK41.64499406
22NTRK11.58782459
23CDK191.53882277
24MAPKAPK31.51363169
25CDK51.50377560
26PRKD31.49467897
27TNIK1.45090310
28KSR11.40924416
29CAMKK21.37779389
30MAPK131.35395372
31SIK21.32929105
32PNCK1.26764879
33GRK51.24844050
34BRAF1.20621362
35MOS1.18746026
36PRKCG1.15821485
37UHMK11.14162701
38MARK21.10888259
39TYRO31.02839183
40PRPF4B1.02832745
41MAP3K111.00071186
42NME10.98225767
43CDK180.97925976
44PHKG20.97484895
45PHKG10.97484895
46TAOK10.96911469
47CDK150.96397831
48CDK140.94284207
49SGK4940.92651052
50SGK2230.92651052
51FES0.91835974
52MAP3K130.91722367
53TESK10.91192693
54CAMK2A0.90618737
55LATS20.90223758
56CAMK10.89550314
57RET0.87973250
58OXSR10.86627692
59PTK2B0.85372677
60RIPK10.83738378
61CDK11A0.83665505
62STK160.80572108
63DYRK1A0.78789075
64STK110.78779883
65ABL20.78282659
66MAP3K20.71005391
67DAPK30.70792198
68ARAF0.69825178
69LMTK20.67588938
70STK380.66451703
71BMPR20.65658045
72SGK20.64069475
73PAK30.63540178
74PRKCE0.61454702
75WNK40.60013636
76CAMK2B0.59100295
77SGK10.58842444
78CAMK40.57763788
79MAPK120.55958730
80PINK10.55042724
81PRKCZ0.54834010
82DYRK20.53729143
83CSNK1G20.53057457
84FGR0.52984398
85ALK0.52826815
86NEK60.52161432
87AKT30.48573602
88PIM20.48040045
89SIK10.46868835
90PDPK10.46727398
91PDK10.45727748
92RAF10.44692132
93PRKCH0.43630642
94ADRBK10.43111019
95WNK30.42987635
96CSNK1G30.42979316
97MAP3K70.42645319
98ROCK20.41469098
99RPS6KA30.41331641
100MAP2K10.40985873
101FYN0.40557741
102TAOK20.40353932
103SIK30.39827238
104GRK70.39546830
105ICK0.37828659
106MAPK70.37567733
107PRKG10.36520582
108MAPK150.36345816
109CAMK1G0.36328914
110SGK30.34855834
111STK38L0.34616472
112CSNK1A1L0.34600792
113CAMK2D0.34032092
114PKN10.33825744
115PRKD10.33656677
116MAP3K10.33363535
117DYRK1B0.33150220
118PRKCB0.32619883
119CSF1R0.32358057
120WNK10.32192795
121SCYL20.31734868
122MAPKAPK50.31210664
123CAMK2G0.30914443
124PRKACA0.30483119
125MAPK100.28599174
126RPS6KA20.26819976
127TNK20.26279462

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.80597724
2Synaptic vesicle cycle_Homo sapiens_hsa047213.74236379
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.84567608
4GABAergic synapse_Homo sapiens_hsa047272.79143241
5Circadian entrainment_Homo sapiens_hsa047132.69911758
6Morphine addiction_Homo sapiens_hsa050322.68084974
7Olfactory transduction_Homo sapiens_hsa047402.62653255
8Glutamatergic synapse_Homo sapiens_hsa047242.53741067
9Amphetamine addiction_Homo sapiens_hsa050312.48975075
10Long-term potentiation_Homo sapiens_hsa047202.48320726
11Dopaminergic synapse_Homo sapiens_hsa047282.30965560
12Cholinergic synapse_Homo sapiens_hsa047252.12342185
13Salivary secretion_Homo sapiens_hsa049702.12227655
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11643103
15Insulin secretion_Homo sapiens_hsa049112.04584668
16Renin secretion_Homo sapiens_hsa049241.91013369
17Cocaine addiction_Homo sapiens_hsa050301.89955432
18Oxytocin signaling pathway_Homo sapiens_hsa049211.85814171
19Gastric acid secretion_Homo sapiens_hsa049711.84611156
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82156185
21Long-term depression_Homo sapiens_hsa047301.77844032
22Serotonergic synapse_Homo sapiens_hsa047261.75287815
23Collecting duct acid secretion_Homo sapiens_hsa049661.73529008
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72550449
25Taste transduction_Homo sapiens_hsa047421.64418309
26Calcium signaling pathway_Homo sapiens_hsa040201.54900730
27Gap junction_Homo sapiens_hsa045401.47956440
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37059287
29GnRH signaling pathway_Homo sapiens_hsa049121.36753063
30Cardiac muscle contraction_Homo sapiens_hsa042601.32217882
31Axon guidance_Homo sapiens_hsa043601.31940526
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29938513
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26546265
34cAMP signaling pathway_Homo sapiens_hsa040241.16658973
35Estrogen signaling pathway_Homo sapiens_hsa049151.12466448
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12199408
37Type II diabetes mellitus_Homo sapiens_hsa049301.09914237
38Vibrio cholerae infection_Homo sapiens_hsa051101.09640573
39ErbB signaling pathway_Homo sapiens_hsa040121.08220400
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03914631
41cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99777344
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98321463
43Glioma_Homo sapiens_hsa052140.98317687
44Phototransduction_Homo sapiens_hsa047440.97748967
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.96554150
46Sulfur relay system_Homo sapiens_hsa041220.95411450
47Vitamin B6 metabolism_Homo sapiens_hsa007500.94631549
48Melanogenesis_Homo sapiens_hsa049160.93146552
49Dilated cardiomyopathy_Homo sapiens_hsa054140.91817635
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91235658
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87835366
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86362928
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85700446
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82497266
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81351724
56Oocyte meiosis_Homo sapiens_hsa041140.75740734
57Alzheimers disease_Homo sapiens_hsa050100.74191938
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72519924
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.71844794
60Oxidative phosphorylation_Homo sapiens_hsa001900.71364607
61MAPK signaling pathway_Homo sapiens_hsa040100.71093460
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.71041752
63Dorso-ventral axis formation_Homo sapiens_hsa043200.69761790
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67139884
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64563999
66Choline metabolism in cancer_Homo sapiens_hsa052310.64520198
67Parkinsons disease_Homo sapiens_hsa050120.64055109
68Alcoholism_Homo sapiens_hsa050340.63074834
69Pancreatic secretion_Homo sapiens_hsa049720.62639350
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62069694
71Thyroid hormone synthesis_Homo sapiens_hsa049180.61689620
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61425954
73VEGF signaling pathway_Homo sapiens_hsa043700.60993862
74Prion diseases_Homo sapiens_hsa050200.60216803
75Legionellosis_Homo sapiens_hsa051340.55079473
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54980763
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54933631
78Circadian rhythm_Homo sapiens_hsa047100.52938654
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.52445372
80Ras signaling pathway_Homo sapiens_hsa040140.52411612
81Renal cell carcinoma_Homo sapiens_hsa052110.51716378
82Glucagon signaling pathway_Homo sapiens_hsa049220.49099575
83Rap1 signaling pathway_Homo sapiens_hsa040150.48115005
84Nitrogen metabolism_Homo sapiens_hsa009100.48052822
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47794085
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47768217
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.47017915
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46138834
89Sphingolipid metabolism_Homo sapiens_hsa006000.45333829
90Arginine and proline metabolism_Homo sapiens_hsa003300.44824169
91Wnt signaling pathway_Homo sapiens_hsa043100.42527007
92Insulin signaling pathway_Homo sapiens_hsa049100.41435411
93mTOR signaling pathway_Homo sapiens_hsa041500.40952527
94Bile secretion_Homo sapiens_hsa049760.40021491
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39489478
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38267523
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37717497
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36417390
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35653636
100Endometrial cancer_Homo sapiens_hsa052130.33569435
101Huntingtons disease_Homo sapiens_hsa050160.33453030
102Folate biosynthesis_Homo sapiens_hsa007900.33136193
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32563095
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32475373
105Lysosome_Homo sapiens_hsa041420.32372605
106Endocytosis_Homo sapiens_hsa041440.31940878
107African trypanosomiasis_Homo sapiens_hsa051430.31490283
108Notch signaling pathway_Homo sapiens_hsa043300.30395109
109Inositol phosphate metabolism_Homo sapiens_hsa005620.30152133
110Chemokine signaling pathway_Homo sapiens_hsa040620.29747082
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29664019
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29652953
113Ovarian steroidogenesis_Homo sapiens_hsa049130.27410410
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27344792
115AMPK signaling pathway_Homo sapiens_hsa041520.26059478
116Non-small cell lung cancer_Homo sapiens_hsa052230.25622672
117N-Glycan biosynthesis_Homo sapiens_hsa005100.24157712

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