RASGRF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.37557610
2synaptic vesicle maturation (GO:0016188)5.89070242
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.77358609
4synaptic vesicle exocytosis (GO:0016079)5.77224126
5vocalization behavior (GO:0071625)5.49503728
6glutamate secretion (GO:0014047)5.33372440
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.30889216
8regulation of synaptic vesicle exocytosis (GO:2000300)5.18410230
9locomotory exploration behavior (GO:0035641)5.17298674
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.83984410
11L-amino acid import (GO:0043092)4.83921140
12protein localization to synapse (GO:0035418)4.82516776
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.70455934
14neurotransmitter secretion (GO:0007269)4.67284283
15neuron cell-cell adhesion (GO:0007158)4.66779425
16regulation of synaptic vesicle transport (GO:1902803)4.60570357
17amino acid import (GO:0043090)4.49042048
18* regulation of glutamate receptor signaling pathway (GO:1900449)4.47961997
19positive regulation of dendritic spine morphogenesis (GO:0061003)4.28487242
20neuronal action potential propagation (GO:0019227)4.20534798
21exploration behavior (GO:0035640)4.12973307
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.09142244
23regulation of neuronal synaptic plasticity (GO:0048168)4.05200863
24layer formation in cerebral cortex (GO:0021819)3.99700202
25cellular potassium ion homeostasis (GO:0030007)3.96145900
26* regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.95976829
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.95423377
28neurotransmitter transport (GO:0006836)3.95181892
29proline transport (GO:0015824)3.94756733
30activation of protein kinase A activity (GO:0034199)3.89093714
31gamma-aminobutyric acid transport (GO:0015812)3.88212872
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.87714467
33central nervous system myelination (GO:0022010)3.78134500
34axon ensheathment in central nervous system (GO:0032291)3.78134500
35neuromuscular process controlling posture (GO:0050884)3.76851276
36synaptic transmission, glutamatergic (GO:0035249)3.74512569
37dendritic spine morphogenesis (GO:0060997)3.72235846
38glutamate receptor signaling pathway (GO:0007215)3.72123531
39positive regulation of dendritic spine development (GO:0060999)3.69822585
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.69644903
41neurotransmitter-gated ion channel clustering (GO:0072578)3.66033988
42neuron-neuron synaptic transmission (GO:0007270)3.65733628
43positive regulation of membrane potential (GO:0045838)3.63981841
44sodium ion export (GO:0071436)3.63890580
45long-term memory (GO:0007616)3.63502610
46negative regulation of dendrite morphogenesis (GO:0050774)3.60933427
47neuron recognition (GO:0008038)3.59650064
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.58459745
49regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.58331522
50positive regulation of synaptic transmission, GABAergic (GO:0032230)3.54287255
51regulation of neurotransmitter levels (GO:0001505)3.50505908
52cerebellar granule cell differentiation (GO:0021707)3.48595196
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.47112822
54regulation of postsynaptic membrane potential (GO:0060078)3.47095273
55synaptic vesicle endocytosis (GO:0048488)3.46863474
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.45042216
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.44765643
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.44392710
59regulation of neurotransmitter secretion (GO:0046928)3.44008585
60transmission of nerve impulse (GO:0019226)3.40681282
61regulation of synapse structural plasticity (GO:0051823)3.39254771
62regulation of synapse maturation (GO:0090128)3.39051396
63regulation of vesicle fusion (GO:0031338)3.37370698
64membrane hyperpolarization (GO:0060081)3.32865383
65response to histamine (GO:0034776)3.30200397
66regulation of dendritic spine development (GO:0060998)3.28441334
67regulation of voltage-gated calcium channel activity (GO:1901385)3.27013723
68cerebellar Purkinje cell differentiation (GO:0021702)3.25066159
69positive regulation of synapse maturation (GO:0090129)3.21156180
70regulation of synaptic plasticity (GO:0048167)3.20915736
71axonal fasciculation (GO:0007413)3.18990155
72cellular sodium ion homeostasis (GO:0006883)3.17658762
73positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.16896924
74long-term synaptic potentiation (GO:0060291)3.15440237
75cell communication by electrical coupling (GO:0010644)3.14717090
76regulation of synaptic transmission, glutamatergic (GO:0051966)3.14266941
77regulation of neurotransmitter transport (GO:0051588)3.12401882
78membrane depolarization during action potential (GO:0086010)3.11987777
79mating behavior (GO:0007617)3.09666990
80presynaptic membrane assembly (GO:0097105)3.08819594
81vesicle transport along microtubule (GO:0047496)3.06604627
82postsynaptic membrane organization (GO:0001941)3.05916986
83positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.04797285
84intraspecies interaction between organisms (GO:0051703)3.04416923
85social behavior (GO:0035176)3.04416923
86acidic amino acid transport (GO:0015800)3.04267408
87detection of calcium ion (GO:0005513)3.00549712
88membrane depolarization (GO:0051899)3.00252294
89positive regulation of neurotransmitter transport (GO:0051590)3.00148139
90synapse assembly (GO:0007416)2.99334597
91G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.99004532
92positive regulation of potassium ion transmembrane transport (GO:1901381)2.97708306
93regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95716028
94* synaptic transmission (GO:0007268)2.95427211
95glycine transport (GO:0015816)2.95244686
96positive regulation of synaptic transmission (GO:0050806)2.93611209
97regulation of calcium ion-dependent exocytosis (GO:0017158)2.93378453
98innervation (GO:0060384)2.92343923
99regulation of dendritic spine morphogenesis (GO:0061001)2.92160995
100startle response (GO:0001964)2.91807640
101dendrite morphogenesis (GO:0048813)2.91628017
102neuromuscular process controlling balance (GO:0050885)2.89665505
103cytoskeletal anchoring at plasma membrane (GO:0007016)2.88281955
104positive regulation of neurotransmitter secretion (GO:0001956)2.88142572
105response to auditory stimulus (GO:0010996)2.87823485
106potassium ion homeostasis (GO:0055075)2.87653814
107calcium ion-dependent exocytosis (GO:0017156)2.87451257
108regulation of synaptic transmission (GO:0050804)2.86197415
109regulation of synaptic transmission, GABAergic (GO:0032228)2.85439155
110synaptic vesicle transport (GO:0048489)2.83690213
111establishment of synaptic vesicle localization (GO:0097480)2.83690213
112regulation of ARF protein signal transduction (GO:0032012)2.83424472
113presynaptic membrane organization (GO:0097090)2.82950467
114learning (GO:0007612)2.82878101
115potassium ion import (GO:0010107)2.82462521
116neuronal ion channel clustering (GO:0045161)2.81863007
117C4-dicarboxylate transport (GO:0015740)2.80310567
118neurotransmitter uptake (GO:0001504)2.78481582
119regulation of cell communication by electrical coupling (GO:0010649)2.75044069
120positive regulation of Rap GTPase activity (GO:0032854)2.72431104
121cell communication involved in cardiac conduction (GO:0086065)2.72003980
122positive regulation of dendrite development (GO:1900006)2.71745511
123regulation of dendrite morphogenesis (GO:0048814)2.71165677
124L-glutamate transport (GO:0015813)2.69464435
125regulation of Rap GTPase activity (GO:0032317)2.64764455
126serotonin metabolic process (GO:0042428)2.64354482
127primary amino compound metabolic process (GO:1901160)2.63171917
128vesicle docking involved in exocytosis (GO:0006904)2.60642788
129positive regulation of fibroblast migration (GO:0010763)2.60162883
130positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.55518862
131vesicle docking (GO:0048278)2.52375347
132dicarboxylic acid transport (GO:0006835)2.48865404

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.06188093
2GBX2_23144817_ChIP-Seq_PC3_Human3.58675796
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03923311
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94807334
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84598063
6REST_21632747_ChIP-Seq_MESCs_Mouse2.74103867
7DROSHA_22980978_ChIP-Seq_HELA_Human2.53183941
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50996045
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50996045
10* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48861811
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47985622
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46922383
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45061709
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36070140
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33281721
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.33080394
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.32407084
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.22683057
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15718019
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14279550
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.12855473
22* EED_16625203_ChIP-ChIP_MESCs_Mouse2.08148931
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.02843265
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98873578
25TAF15_26573619_Chip-Seq_HEK293_Human1.97266035
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97145741
27AR_21572438_ChIP-Seq_LNCaP_Human1.93708500
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91111556
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88491170
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85155504
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78858742
32SMAD4_21799915_ChIP-Seq_A2780_Human1.77263848
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66116443
34CTNNB1_20460455_ChIP-Seq_HCT116_Human1.65683450
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52572649
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49687129
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48457215
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47531548
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46419873
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45915618
41* P300_19829295_ChIP-Seq_ESCs_Human1.45870839
42ZNF274_21170338_ChIP-Seq_K562_Hela1.45521207
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.43960917
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43300743
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39786776
46* SOX2_21211035_ChIP-Seq_LN229_Gbm1.38395576
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.37799972
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36438741
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.36111146
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36102066
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35152464
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.33429474
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.32665383
54AR_25329375_ChIP-Seq_VCAP_Human1.32307009
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32118324
56IGF1R_20145208_ChIP-Seq_DFB_Human1.31471003
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.30793180
58STAT3_23295773_ChIP-Seq_U87_Human1.30686745
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27215468
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25663332
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25328002
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.25245917
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.21051786
64* AR_19668381_ChIP-Seq_PC3_Human1.20922983
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20874740
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20587577
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.19186365
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19126711
69* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17994848
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16590723
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14952999
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14896060
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14020555
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13892482
75* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13760934
76* TCF4_23295773_ChIP-Seq_U87_Human1.12752177
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11397027
78RNF2_27304074_Chip-Seq_NSC_Mouse1.10755523
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09686533
80WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09638712
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08336457
82* ARNT_22903824_ChIP-Seq_MCF-7_Human1.07759601
83DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07729813
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07478955
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07448550
86SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05359769
87* AHR_22903824_ChIP-Seq_MCF-7_Human1.04666115
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03665067
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03441701
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03441701
91* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02811859
92RUNX2_22187159_ChIP-Seq_PCA_Human1.02136860
93KDM2B_26808549_Chip-Seq_REH_Human1.02120029
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00553022
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00344265
96ER_23166858_ChIP-Seq_MCF-7_Human1.00028869
97FUS_26573619_Chip-Seq_HEK293_Human0.99739631
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97955926
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.96682578
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.96271296
101RING1B_27294783_Chip-Seq_NPCs_Mouse0.96223837
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95836802
103ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95503291
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95000118
105GATA2_21666600_ChIP-Seq_HMVEC_Human0.94855117
106SMAD4_21741376_ChIP-Seq_HESCs_Human0.93875898
107DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93454055
108ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93330109
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.90684781
110TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90398737
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90368990
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90155919
113BCAT_22108803_ChIP-Seq_LS180_Human0.89873825
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89311116
115NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89126322
116TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88946437
117* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88225092
118JUN_21703547_ChIP-Seq_K562_Human0.88036821
119* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87483298
120KDM2B_26808549_Chip-Seq_K562_Human0.86882198
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86728897
122TP53_16413492_ChIP-PET_HCT116_Human0.85844967
123NANOG_18555785_Chip-Seq_ESCs_Mouse0.85589052
124CBP_20019798_ChIP-Seq_JUKART_Human0.82705996

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.82237102
2MP0003880_abnormal_central_pattern5.00064133
3MP0003635_abnormal_synaptic_transmissio3.97289889
4MP0004270_analgesia3.43344527
5MP0009745_abnormal_behavioral_response3.32227230
6MP0009046_muscle_twitch3.19336528
7MP0002064_seizures3.17826657
8MP0001968_abnormal_touch/_nociception3.08586543
9MP0002063_abnormal_learning/memory/cond3.06469594
10MP0005423_abnormal_somatic_nervous2.94008789
11MP0002572_abnormal_emotion/affect_behav2.66979974
12MP0002734_abnormal_mechanical_nocicepti2.60412225
13MP0002272_abnormal_nervous_system2.53250474
14MP0001486_abnormal_startle_reflex2.53198797
15MP0001501_abnormal_sleep_pattern2.41929506
16MP0002822_catalepsy2.22002976
17MP0002736_abnormal_nociception_after2.19020756
18MP0001440_abnormal_grooming_behavior2.14519331
19MP0002735_abnormal_chemical_nociception2.09692761
20MP0006276_abnormal_autonomic_nervous2.04991388
21MP0005551_abnormal_eye_electrophysiolog2.04723219
22MP0009780_abnormal_chondrocyte_physiolo2.01251837
23MP0002067_abnormal_sensory_capabilities1.98370397
24MP0002733_abnormal_thermal_nociception1.96344339
25MP0001970_abnormal_pain_threshold1.87085683
26MP0003122_maternal_imprinting1.85145038
27MP0002909_abnormal_adrenal_gland1.82930321
28MP0005645_abnormal_hypothalamus_physiol1.76355305
29MP0005386_behavior/neurological_phenoty1.76080249
30MP0004924_abnormal_behavior1.76080249
31MP0008569_lethality_at_weaning1.72822631
32MP0002557_abnormal_social/conspecific_i1.69268191
33MP0003787_abnormal_imprinting1.67843673
34MP0002184_abnormal_innervation1.66330372
35MP0003329_amyloid_beta_deposits1.63942857
36MP0001984_abnormal_olfaction1.61678275
37MP0005646_abnormal_pituitary_gland1.58625248
38MP0001502_abnormal_circadian_rhythm1.55037470
39MP0004811_abnormal_neuron_physiology1.54095854
40MP0004858_abnormal_nervous_system1.51338554
41MP0010368_abnormal_lymphatic_system1.50419322
42MP0006072_abnormal_retinal_apoptosis1.50135677
43MP0000778_abnormal_nervous_system1.49217445
44MP0003879_abnormal_hair_cell1.47984848
45MP0002882_abnormal_neuron_morphology1.41890573
46MP0000013_abnormal_adipose_tissue1.38593038
47MP0002837_dystrophic_cardiac_calcinosis1.35466100
48MP0000955_abnormal_spinal_cord1.35231879
49MP0004885_abnormal_endolymph1.35165115
50MP0002066_abnormal_motor_capabilities/c1.34915547
51MP0004142_abnormal_muscle_tone1.33091214
52MP0003633_abnormal_nervous_system1.30345672
53MP0010386_abnormal_urinary_bladder1.29326424
54MP0002229_neurodegeneration1.24868584
55MP0001529_abnormal_vocalization1.24163944
56MP0005253_abnormal_eye_physiology1.20823627
57MP0001986_abnormal_taste_sensitivity1.20075345
58MP0002090_abnormal_vision1.20011548
59MP0001905_abnormal_dopamine_level1.18828098
60MP0000751_myopathy1.12940013
61MP0004145_abnormal_muscle_electrophysio1.06381830
62MP0005623_abnormal_meninges_morphology1.05755827
63MP0005410_abnormal_fertilization1.04145934
64MP0002638_abnormal_pupillary_reflex1.03233881
65MP0003631_nervous_system_phenotype1.02761418
66MP0008961_abnormal_basal_metabolism0.99339781
67MP0008872_abnormal_physiological_respon0.99224986
68MP0003868_abnormal_feces_composition0.96941903
69MP0002069_abnormal_eating/drinking_beha0.96151150
70MP0005535_abnormal_body_temperature0.95891025
71MP0002152_abnormal_brain_morphology0.95368665
72MP0001188_hyperpigmentation0.94329392
73MP0004215_abnormal_myocardial_fiber0.94124615
74MP0005409_darkened_coat_color0.91989154
75MP0008877_abnormal_DNA_methylation0.91834584
76MP0003690_abnormal_glial_cell0.87448665
77MP0001348_abnormal_lacrimal_gland0.87401667
78MP0001299_abnormal_eye_distance/0.85762923
79MP0004085_abnormal_heartbeat0.85705806
80MP0001177_atelectasis0.85693368
81MP0002752_abnormal_somatic_nervous0.85356129
82MP0002876_abnormal_thyroid_physiology0.85337381
83MP0003878_abnormal_ear_physiology0.84170586
84MP0005377_hearing/vestibular/ear_phenot0.84170586
85MP0003634_abnormal_glial_cell0.82697236
86MP0005670_abnormal_white_adipose0.82083938
87MP0000569_abnormal_digit_pigmentation0.81551364
88MP0004742_abnormal_vestibular_system0.80292323
89MP0001963_abnormal_hearing_physiology0.79859625
90MP0008874_decreased_physiological_sensi0.79403137
91MP0003283_abnormal_digestive_organ0.78751845
92MP0003123_paternal_imprinting0.76577989
93MP0000631_abnormal_neuroendocrine_gland0.75409135
94MP0004036_abnormal_muscle_relaxation0.72202757
95MP0001485_abnormal_pinna_reflex0.70536897
96MP0003121_genomic_imprinting0.69134613
97MP0004233_abnormal_muscle_weight0.68424996
98MP0001664_abnormal_digestion0.67865753
99MP0004484_altered_response_of0.67864954
100MP0000604_amyloidosis0.66091479
101MP0003172_abnormal_lysosome_physiology0.65263710
102MP0003137_abnormal_impulse_conducting0.64769473
103MP0001346_abnormal_lacrimal_gland0.64549895
104MP0010329_abnormal_lipoprotein_level0.64462731
105MP0010234_abnormal_vibrissa_follicle0.64447454
106MP0004130_abnormal_muscle_cell0.64348102
107MP0001915_intracranial_hemorrhage0.63242165
108MP0006138_congestive_heart_failure0.63169886
109MP0005187_abnormal_penis_morphology0.63081879
110MP0002089_abnormal_postnatal_growth/wei0.62829677
111MP0004043_abnormal_pH_regulation0.62827882
112MP0009672_abnormal_birth_weight0.61619378
113MP0003632_abnormal_nervous_system0.61582408
114MP0005195_abnormal_posterior_eye0.61529532
115MP0000920_abnormal_myelination0.61445754
116MP0003075_altered_response_to0.61176765
117MP0005394_taste/olfaction_phenotype0.60323671
118MP0005499_abnormal_olfactory_system0.60323671
119MP0004084_abnormal_cardiac_muscle0.59002401
120MP0005379_endocrine/exocrine_gland_phen0.58693284
121MP0005448_abnormal_energy_balance0.56968354
122MP0005167_abnormal_blood-brain_barrier0.55310376
123MP0001943_abnormal_respiration0.55222512
124MP0003119_abnormal_digestive_system0.55167561
125MP0010769_abnormal_survival0.50284655
126MP0008057_abnormal_DNA_replication0.49474098
127MP0005620_abnormal_muscle_contractility0.49233977
128MP0002133_abnormal_respiratory_system0.47734705

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.76763759
2Myokymia (HP:0002411)5.62500675
3Focal seizures (HP:0007359)5.57167259
4Visual hallucinations (HP:0002367)5.40318314
5Epileptic encephalopathy (HP:0200134)5.01885560
6Atonic seizures (HP:0010819)5.00955715
7Febrile seizures (HP:0002373)4.76832936
8Absence seizures (HP:0002121)4.63504935
9Dialeptic seizures (HP:0011146)4.18089266
10Progressive cerebellar ataxia (HP:0002073)4.09445481
11Generalized tonic-clonic seizures (HP:0002069)4.06809597
12Supranuclear gaze palsy (HP:0000605)3.54301346
13Central scotoma (HP:0000603)3.34340035
14Broad-based gait (HP:0002136)3.31351504
15Action tremor (HP:0002345)3.26647260
16Papilledema (HP:0001085)3.24792398
17Abnormal eating behavior (HP:0100738)3.19310065
18Hyperventilation (HP:0002883)3.15742726
19Depression (HP:0000716)3.15112313
20Dysdiadochokinesis (HP:0002075)3.08672319
21Truncal ataxia (HP:0002078)3.07569517
22Poor eye contact (HP:0000817)3.05255462
23Ankle clonus (HP:0011448)3.01245588
24Anxiety (HP:0000739)2.98101291
25Congenital stationary night blindness (HP:0007642)2.96907666
26Hepatoblastoma (HP:0002884)2.96779713
27Progressive inability to walk (HP:0002505)2.94700220
28Abnormal social behavior (HP:0012433)2.94421764
29Impaired social interactions (HP:0000735)2.94421764
30Gaze-evoked nystagmus (HP:0000640)2.93981202
31Mutism (HP:0002300)2.89303379
32Obstructive sleep apnea (HP:0002870)2.87692855
33Postural instability (HP:0002172)2.87349385
34Dysmetria (HP:0001310)2.81494482
35Annular pancreas (HP:0001734)2.80580062
36Ventricular fibrillation (HP:0001663)2.80352364
37Urinary bladder sphincter dysfunction (HP:0002839)2.78571361
38Abnormality of macular pigmentation (HP:0008002)2.77665080
39Impaired vibration sensation in the lower limbs (HP:0002166)2.74522412
40Polyphagia (HP:0002591)2.69841895
41Genetic anticipation (HP:0003743)2.68431729
42Pheochromocytoma (HP:0002666)2.65179393
43Amblyopia (HP:0000646)2.61945945
44Arterial tortuosity (HP:0005116)2.59081740
45Hemiparesis (HP:0001269)2.58842090
46Epileptiform EEG discharges (HP:0011182)2.57428015
47Drooling (HP:0002307)2.56961433
48Excessive salivation (HP:0003781)2.56961433
49EEG with generalized epileptiform discharges (HP:0011198)2.53629157
50Amyotrophic lateral sclerosis (HP:0007354)2.51391727
51Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.51137173
52Clonus (HP:0002169)2.49352653
53Agitation (HP:0000713)2.44745759
54Bradykinesia (HP:0002067)2.44537678
55Scanning speech (HP:0002168)2.40296751
56Hemiplegia (HP:0002301)2.38815122
57Neurofibrillary tangles (HP:0002185)2.38801070
58Status epilepticus (HP:0002133)2.37873786
59Hypsarrhythmia (HP:0002521)2.36117067
60Urinary urgency (HP:0000012)2.34603554
61Scotoma (HP:0000575)2.34589770
62Impaired smooth pursuit (HP:0007772)2.34570341
63Inability to walk (HP:0002540)2.34526489
64Spastic gait (HP:0002064)2.33981872
65Generalized myoclonic seizures (HP:0002123)2.31351920
66Intention tremor (HP:0002080)2.30459712
67Vascular tortuosity (HP:0004948)2.27767759
68Deep venous thrombosis (HP:0002625)2.27448164
69Absent speech (HP:0001344)2.25880332
70Neuroendocrine neoplasm (HP:0100634)2.25575314
71Resting tremor (HP:0002322)2.24542238
72Limb dystonia (HP:0002451)2.24287914
73Cerebral inclusion bodies (HP:0100314)2.23651435
74Gait imbalance (HP:0002141)2.22779505
75Tetraplegia (HP:0002445)2.21559022
76Fetal akinesia sequence (HP:0001989)2.19999267
77Bronchomalacia (HP:0002780)2.18970276
78Diplopia (HP:0000651)2.17231479
79Abnormality of binocular vision (HP:0011514)2.17231479
80Decreased motor nerve conduction velocity (HP:0003431)2.15801804
81Peripheral hypomyelination (HP:0007182)2.13801869
82Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.13620984
83Abnormal EKG (HP:0003115)2.12021764
84Failure to thrive in infancy (HP:0001531)2.12017365
85Bony spicule pigmentary retinopathy (HP:0007737)2.11293337
86Abnormality of the lower motor neuron (HP:0002366)2.11194683
87Hypoventilation (HP:0002791)2.08271377
88Hyperthyroidism (HP:0000836)2.07006850
89Termporal pattern (HP:0011008)2.06091142
90Insidious onset (HP:0003587)2.06091142
91Torticollis (HP:0000473)2.04621923
92Abnormality of ocular smooth pursuit (HP:0000617)2.04299601
93Lower limb muscle weakness (HP:0007340)2.02168054
94Blue irides (HP:0000635)1.99234111
95Psychosis (HP:0000709)1.98398736
96Prolonged QT interval (HP:0001657)1.97586094
97Dyschromatopsia (HP:0007641)1.94137572
98Abnormal rod and cone electroretinograms (HP:0008323)1.93287279
99Stereotypic behavior (HP:0000733)1.93093385
100Dysmetric saccades (HP:0000641)1.92844921
101Bundle branch block (HP:0011710)1.91568650
102Papillary thyroid carcinoma (HP:0002895)1.89976372
103Focal dystonia (HP:0004373)1.88665829
104Specific learning disability (HP:0001328)1.87159598
105Gait ataxia (HP:0002066)1.86363309
106Hypercortisolism (HP:0001578)1.84264496
107Congenital primary aphakia (HP:0007707)1.84221412
108Craniofacial dystonia (HP:0012179)1.83876020
109Impaired vibratory sensation (HP:0002495)1.83384122
110Menstrual irregularities (HP:0000858)1.83025180
111Abnormality of the corticospinal tract (HP:0002492)1.81542144
112Rapidly progressive (HP:0003678)1.79404040
113Difficulty running (HP:0009046)1.77560121
114Neuronal loss in central nervous system (HP:0002529)1.77159805
115Rigidity (HP:0002063)1.75754008
116Alacrima (HP:0000522)1.75667850
117Delusions (HP:0000746)1.75016856
118Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74885714
119Megalencephaly (HP:0001355)1.74711258
120Abnormality of salivation (HP:0100755)1.74297514
121Sleep apnea (HP:0010535)1.74268147
122Increased circulating renin level (HP:0000848)1.72472092
123Slow progression (HP:0003677)1.70674469
124Akinesia (HP:0002304)1.69795170
125Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.69524392
126Lower limb asymmetry (HP:0100559)1.65767521
127Split foot (HP:0001839)1.65530369
128Aplasia involving bones of the upper limbs (HP:0009823)1.65400582
129Aplasia of the phalanges of the hand (HP:0009802)1.65400582
130Aplasia involving bones of the extremities (HP:0009825)1.65400582
131Menorrhagia (HP:0000132)1.64504618
132Joint hemorrhage (HP:0005261)1.63807530
133Thickened helices (HP:0000391)1.63378211
134Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.63255766
135Degeneration of the lateral corticospinal tracts (HP:0002314)1.63255766
136Cerebral hypomyelination (HP:0006808)1.59960677
137Deeply set eye (HP:0000490)1.59317874

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.61353128
2MAP3K93.99884544
3MAP3K43.23098863
4EPHA43.11069583
5MARK13.00228809
6MINK12.67989542
7MAP2K72.60365820
8MAP3K122.48968236
9DAPK22.40426076
10PAK62.17697052
11NTRK22.16025900
12MAP2K42.15490044
13PRKD31.95432284
14KSR21.92445074
15CASK1.88268459
16PNCK1.86056318
17NTRK11.81909466
18FGFR21.76893054
19TNIK1.76548800
20CAMKK11.64439716
21ARAF1.47103946
22* CDK51.44855127
23KSR11.42112288
24GRK51.37243470
25DAPK11.36562989
26STK381.35707687
27PLK21.34466935
28CDK191.33037280
29MAP3K21.31852065
30MAP3K131.31630507
31MAPK131.24720088
32FES1.23298509
33LMTK21.23241691
34FGFR31.22824334
35PHKG21.20505578
36PHKG11.20505578
37SIK21.17767120
38PRPF4B1.16673087
39PRKCG1.15553085
40UHMK11.14523954
41CAMK2A1.04346391
42RIPK41.00981003
43CAMKK21.00484760
44CAMK1D1.00156413
45CAMK10.98925421
46PRKCH0.98437386
47CAMK1G0.98076066
48LATS20.96085714
49FGFR40.94859391
50PAK30.94324181
51SGK4940.92646322
52SGK2230.92646322
53CAMK40.92362940
54STK110.90878725
55PDGFRA0.90745592
56LATS10.88080128
57WNK30.84005880
58TNK20.82878309
59MAP3K10.81767052
60OXSR10.81435189
61RET0.81340401
62PINK10.81241384
63SGK20.80745193
64TYRO30.79490588
65CDK140.77573007
66CDK180.76980955
67CDK150.75477557
68CSNK1G20.74173705
69SGK30.72925935
70TIE10.72118108
71SGK10.70776800
72CAMK2B0.69464707
73NME10.69341559
74TAOK10.65807603
75DYRK1A0.65153724
76CAMK2D0.65127657
77STK38L0.64781571
78CDK11A0.63640936
79PIK3CA0.63526815
80PDK10.62946944
81SCYL20.61814414
82STK390.61034314
83RAF10.59821136
84PRKCE0.58882259
85CDC42BPA0.58720415
86AKT30.57768038
87PDPK10.57544320
88PDGFRB0.57282111
89MARK20.57200813
90FER0.55871706
91CCNB10.55052479
92WNK10.54681467
93ICK0.54348715
94ALK0.53405292
95RPS6KA30.53107478
96PRKCZ0.51931101
97PRKG10.50666979
98CAMK2G0.48775716
99JAK10.48066701
100MAPK100.46990484
101NEK60.46395070
102FRK0.46358475
103MAP3K70.46230173
104PTK2B0.42798685
105CDK120.41929830
106MAP3K60.39838053
107BMPR20.39189403
108MYLK0.38622756
109FYN0.38232720
110FGFR10.37968968
111WNK40.37840569
112GRK70.37411355
113PRKAA20.36122511
114MAPK120.35985966
115PRKCB0.35367062
116MAP2K10.35308679
117ROCK20.35287642
118RIPK10.35049254
119PRKAA10.34904515
120CSNK1D0.34870070
121RPS6KA20.34738234
122PRKACA0.31927908

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.69440533
2Synaptic vesicle cycle_Homo sapiens_hsa047213.57111598
3GABAergic synapse_Homo sapiens_hsa047272.94396830
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72021389
5Olfactory transduction_Homo sapiens_hsa047402.62918021
6Circadian entrainment_Homo sapiens_hsa047132.56755629
7Morphine addiction_Homo sapiens_hsa050322.49607126
8Glutamatergic synapse_Homo sapiens_hsa047242.35969228
9Long-term potentiation_Homo sapiens_hsa047202.31902305
10Insulin secretion_Homo sapiens_hsa049112.23657794
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22319927
12Amphetamine addiction_Homo sapiens_hsa050312.19665487
13Phototransduction_Homo sapiens_hsa047442.18157959
14Salivary secretion_Homo sapiens_hsa049702.06422456
15Dopaminergic synapse_Homo sapiens_hsa047282.05931948
16Cholinergic synapse_Homo sapiens_hsa047251.86328292
17Gastric acid secretion_Homo sapiens_hsa049711.81711786
18Renin secretion_Homo sapiens_hsa049241.79528138
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74990866
20Collecting duct acid secretion_Homo sapiens_hsa049661.73157128
21Taste transduction_Homo sapiens_hsa047421.72657038
22Serotonergic synapse_Homo sapiens_hsa047261.69266515
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63293740
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60931140
25Oxytocin signaling pathway_Homo sapiens_hsa049211.60625246
26Long-term depression_Homo sapiens_hsa047301.55356385
27Cocaine addiction_Homo sapiens_hsa050301.54034226
28Calcium signaling pathway_Homo sapiens_hsa040201.45378124
29GnRH signaling pathway_Homo sapiens_hsa049121.40986481
30Type II diabetes mellitus_Homo sapiens_hsa049301.27461335
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26971625
32Vibrio cholerae infection_Homo sapiens_hsa051101.25091927
33Vitamin B6 metabolism_Homo sapiens_hsa007501.23390310
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21912306
35cAMP signaling pathway_Homo sapiens_hsa040241.19727443
36Cardiac muscle contraction_Homo sapiens_hsa042601.19331971
37Gap junction_Homo sapiens_hsa045401.18318654
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17870130
39Fatty acid biosynthesis_Homo sapiens_hsa000611.14643772
40Estrogen signaling pathway_Homo sapiens_hsa049151.13059214
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06010611
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03509328
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02897547
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01090706
45Nitrogen metabolism_Homo sapiens_hsa009100.97891319
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.96599588
47Melanogenesis_Homo sapiens_hsa049160.94075748
48Dorso-ventral axis formation_Homo sapiens_hsa043200.91902623
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89197252
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88824929
51ErbB signaling pathway_Homo sapiens_hsa040120.88541706
52Axon guidance_Homo sapiens_hsa043600.87913135
53Glioma_Homo sapiens_hsa052140.86375482
54Dilated cardiomyopathy_Homo sapiens_hsa054140.83272706
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82937671
56Pancreatic secretion_Homo sapiens_hsa049720.81858989
57Type I diabetes mellitus_Homo sapiens_hsa049400.81276795
58Thyroid hormone synthesis_Homo sapiens_hsa049180.79856741
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.73645889
60Oocyte meiosis_Homo sapiens_hsa041140.73063818
61Arginine biosynthesis_Homo sapiens_hsa002200.69704650
62Histidine metabolism_Homo sapiens_hsa003400.69265306
63Adherens junction_Homo sapiens_hsa045200.68853323
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66739875
65Glucagon signaling pathway_Homo sapiens_hsa049220.66309065
66Circadian rhythm_Homo sapiens_hsa047100.65517857
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63721763
68Non-small cell lung cancer_Homo sapiens_hsa052230.62516806
69* MAPK signaling pathway_Homo sapiens_hsa040100.62320913
70Focal adhesion_Homo sapiens_hsa045100.61109553
71Oxidative phosphorylation_Homo sapiens_hsa001900.59172475
72Choline metabolism in cancer_Homo sapiens_hsa052310.59138924
73Alzheimers disease_Homo sapiens_hsa050100.57592240
74AMPK signaling pathway_Homo sapiens_hsa041520.57257923
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56913736
76Hippo signaling pathway_Homo sapiens_hsa043900.54859999
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54585006
78Tight junction_Homo sapiens_hsa045300.54076703
79ECM-receptor interaction_Homo sapiens_hsa045120.51907046
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51593398
81Bile secretion_Homo sapiens_hsa049760.50789084
82Inositol phosphate metabolism_Homo sapiens_hsa005620.50223262
83Proteoglycans in cancer_Homo sapiens_hsa052050.49571489
84Platelet activation_Homo sapiens_hsa046110.49558591
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47930993
86Prion diseases_Homo sapiens_hsa050200.47327235
87PPAR signaling pathway_Homo sapiens_hsa033200.47326871
88* Ras signaling pathway_Homo sapiens_hsa040140.47145623
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.46887643
90Insulin signaling pathway_Homo sapiens_hsa049100.44419819
91Ovarian steroidogenesis_Homo sapiens_hsa049130.44381375
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44148802
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44045265
94FoxO signaling pathway_Homo sapiens_hsa040680.43908497
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42450153
96VEGF signaling pathway_Homo sapiens_hsa043700.42312052
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41855481
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41334334
99Complement and coagulation cascades_Homo sapiens_hsa046100.41031762
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.40599766
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39295979
102Renal cell carcinoma_Homo sapiens_hsa052110.38761851
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38091796
104Alcoholism_Homo sapiens_hsa050340.38014215
105Endocytosis_Homo sapiens_hsa041440.37874532
106Butanoate metabolism_Homo sapiens_hsa006500.37732775
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37428127
108Parkinsons disease_Homo sapiens_hsa050120.37052613
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.36236398
110Rap1 signaling pathway_Homo sapiens_hsa040150.36058188
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35804594
112mTOR signaling pathway_Homo sapiens_hsa041500.35661959
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35552969
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35352938
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35074187
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33058384
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33038731
118Wnt signaling pathway_Homo sapiens_hsa043100.30325822
119Rheumatoid arthritis_Homo sapiens_hsa053230.27698611
120Endometrial cancer_Homo sapiens_hsa052130.27560943

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