RASGRP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.52168990
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.22084284
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.83418995
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.83418995
5negative regulation of cell killing (GO:0031342)5.74772541
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.74772541
7B cell receptor signaling pathway (GO:0050853)5.69191195
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.62632166
9antigen processing and presentation of endogenous antigen (GO:0019883)5.44806486
10regulation of gamma-delta T cell differentiation (GO:0045586)5.37506816
11negative T cell selection (GO:0043383)5.03177636
12negative thymic T cell selection (GO:0045060)4.97785269
13regulation of gamma-delta T cell activation (GO:0046643)4.89109455
14regulation of B cell receptor signaling pathway (GO:0050855)4.88767388
15negative regulation of phagocytosis (GO:0050765)4.74130446
16positive thymic T cell selection (GO:0045059)4.72897866
17T cell migration (GO:0072678)4.67409840
18positive regulation of B cell differentiation (GO:0045579)4.58320475
19positive regulation by symbiont of host defense response (GO:0052509)4.57254327
20modulation by symbiont of host defense response (GO:0052031)4.57254327
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.57254327
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.57254327
23positive regulation by organism of defense response of other organism involved in symbiotic interact4.57254327
24modulation by symbiont of host immune response (GO:0052553)4.57254327
25detection of bacterium (GO:0016045)4.53192945
26positive T cell selection (GO:0043368)4.51423149
27detection of other organism (GO:0098543)4.50006478
28T cell selection (GO:0045058)4.48545870
29neutrophil activation involved in immune response (GO:0002283)4.47502074
30response to interleukin-15 (GO:0070672)4.47017306
31regulation of B cell differentiation (GO:0045577)4.44106485
32thymic T cell selection (GO:0045061)4.41830166
33mast cell activation involved in immune response (GO:0002279)4.26181914
34mast cell degranulation (GO:0043303)4.26181914
35cellular response to interleukin-15 (GO:0071350)4.10220619
36mast cell activation (GO:0045576)4.08042972
37antigen receptor-mediated signaling pathway (GO:0050851)4.02545524
38leukocyte aggregation (GO:0070486)4.00390111
39interferon-gamma production (GO:0032609)3.98740535
40negative regulation of leukocyte mediated immunity (GO:0002704)3.80687280
41V(D)J recombination (GO:0033151)3.76043969
42response to muramyl dipeptide (GO:0032495)3.74748807
43macrophage activation involved in immune response (GO:0002281)3.74545723
44T cell homeostasis (GO:0043029)3.70618872
45response to peptidoglycan (GO:0032494)3.67088073
46regulation of T cell tolerance induction (GO:0002664)3.65660943
47positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.65469609
48immunoglobulin mediated immune response (GO:0016064)3.64934864
49negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.63844689
50T cell receptor signaling pathway (GO:0050852)3.63128261
51positive regulation of granulocyte differentiation (GO:0030854)3.54227541
52regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.50466021
53negative regulation of interleukin-12 production (GO:0032695)3.49165353
54regulation of tolerance induction (GO:0002643)3.45916165
55detection of external biotic stimulus (GO:0098581)3.41732921
56ribosomal small subunit assembly (GO:0000028)3.39421367
57G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.35157826
58cellular extravasation (GO:0045123)3.31317433
59regulation of mast cell degranulation (GO:0043304)3.30907227
60myeloid cell activation involved in immune response (GO:0002275)3.29949238
61regulation of interferon-beta biosynthetic process (GO:0045357)3.26899630
62lymphocyte homeostasis (GO:0002260)3.25592481
63cAMP catabolic process (GO:0006198)3.25280531
64negative regulation of T-helper cell differentiation (GO:0045623)3.23914233
65negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.23914233
66cellular response to zinc ion (GO:0071294)3.22228360
67mature B cell differentiation (GO:0002335)3.21671603
68angiogenesis involved in wound healing (GO:0060055)3.18578078
69type I interferon signaling pathway (GO:0060337)3.17267928
70cellular response to type I interferon (GO:0071357)3.17267928
71response to type I interferon (GO:0034340)3.16358365
72granulocyte activation (GO:0036230)3.14755263
73regulation of natural killer cell mediated immunity (GO:0002715)3.14208310
74regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.14208310
75regulation of regulatory T cell differentiation (GO:0045589)3.13909969
76negative regulation of innate immune response (GO:0045824)3.13803400
77leukocyte degranulation (GO:0043299)3.13749237
78natural killer cell differentiation (GO:0001779)3.12351855
79response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.10989252
80response to host immune response (GO:0052572)3.10989252
81megakaryocyte development (GO:0035855)3.10858863
82positive regulation of tolerance induction (GO:0002645)3.09906992
83leukocyte migration involved in inflammatory response (GO:0002523)3.07916507
84regulation of myeloid leukocyte mediated immunity (GO:0002886)3.07458636
85regulation of T cell receptor signaling pathway (GO:0050856)3.06644743
86regulation of T cell mediated cytotoxicity (GO:0001914)3.05965260
87germinal center formation (GO:0002467)3.05290876
88regulation of granulocyte differentiation (GO:0030852)3.04950394
89regulation of dendritic cell antigen processing and presentation (GO:0002604)3.03840564
90immune response-activating cell surface receptor signaling pathway (GO:0002429)3.03830807
91adenosine receptor signaling pathway (GO:0001973)3.03610762
92regulation of mast cell activation involved in immune response (GO:0033006)3.01424707
93microglial cell activation (GO:0001774)3.00666023
94regulation of leukocyte degranulation (GO:0043300)3.00074367
95B cell proliferation (GO:0042100)2.99194296
96negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.98006364
97detection of biotic stimulus (GO:0009595)2.97387987
98T cell costimulation (GO:0031295)2.96941855
99adaptation of signaling pathway (GO:0023058)2.93548599
100response to host defenses (GO:0052200)2.92140496
101response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.92140496
102response to host (GO:0075136)2.92140496
103histone H3-K4 trimethylation (GO:0080182)2.90304900
104negative regulation of interleukin-6 production (GO:0032715)2.89873274
105lymphocyte costimulation (GO:0031294)2.89551556
106B cell mediated immunity (GO:0019724)2.89467696
107leukocyte homeostasis (GO:0001776)2.88695439
108positive regulation of T cell mediated cytotoxicity (GO:0001916)2.88529617
109positive regulation of histone deacetylation (GO:0031065)2.86975625
110negative regulation of T cell mediated immunity (GO:0002710)2.85603369
111positive regulation of interleukin-2 production (GO:0032743)2.84190669
112* positive regulation of Rap GTPase activity (GO:0032854)2.83419953
113negative regulation of histone methylation (GO:0031061)2.82908948
114regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.81241682
115positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.79236678
116regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.77845589
117positive regulation of isotype switching (GO:0045830)2.75885930
118regulation of alpha-beta T cell proliferation (GO:0046640)2.74175474
119cyclic nucleotide catabolic process (GO:0009214)2.74032950
120respiratory burst (GO:0045730)2.71441040
121response to protozoan (GO:0001562)2.69750927
122leukocyte cell-cell adhesion (GO:0007159)2.69514632
123mature B cell differentiation involved in immune response (GO:0002313)2.69316995
124viral transcription (GO:0019083)2.67882462
125Peyers patch development (GO:0048541)2.67279409
126mucosal-associated lymphoid tissue development (GO:0048537)2.67279409
127natural killer cell activation (GO:0030101)2.66102377
128lymph node development (GO:0048535)2.65394209
129regulation of interleukin-12 biosynthetic process (GO:0045075)2.64630247
130negative regulation of erythrocyte differentiation (GO:0045647)2.64478261
131tachykinin receptor signaling pathway (GO:0007217)2.64344558
132antigen processing and presentation via MHC class Ib (GO:0002475)2.64030962
133B cell activation (GO:0042113)2.63790330
134synaptic transmission, dopaminergic (GO:0001963)2.61720321
135positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.61346684
136positive regulation of immunoglobulin production (GO:0002639)2.59456640
137negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.58561652
138defense response to protozoan (GO:0042832)2.57485380
139negative regulation of lymphocyte mediated immunity (GO:0002707)2.57272537
140positive regulation of lamellipodium assembly (GO:0010592)2.56635190
141B cell differentiation (GO:0030183)2.55478584
142defense response to fungus (GO:0050832)2.55048686
143B cell homeostasis (GO:0001782)2.54998521
144activated T cell proliferation (GO:0050798)2.54406624
145Arp2/3 complex-mediated actin nucleation (GO:0034314)2.53466718
146prepulse inhibition (GO:0060134)2.53180414
147tolerance induction (GO:0002507)2.52951243
148DNA unwinding involved in DNA replication (GO:0006268)2.52158403
149neutrophil activation (GO:0042119)2.52097786
150mononuclear cell proliferation (GO:0032943)2.51611415
151T cell differentiation (GO:0030217)2.51507640
152myeloid dendritic cell activation (GO:0001773)2.51342149
153regulation of isotype switching to IgG isotypes (GO:0048302)2.50801307

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.30307466
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.73734535
3* MYC_22102868_ChIP-Seq_BL_Human4.57108674
4VDR_21846776_ChIP-Seq_THP-1_Human3.64847518
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.56551300
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.49567588
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.45590653
8SCL_19346495_ChIP-Seq_HPC-7_Human3.11204437
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.03805625
10* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.98386164
11RUNX_20019798_ChIP-Seq_JUKART_Human2.83870916
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.79414425
13UTX_26944678_Chip-Seq_JUKART_Human2.70629378
14* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.69225411
15* MYB_26560356_Chip-Seq_TH2_Human2.66263571
16* MAF_26560356_Chip-Seq_TH1_Human2.63171584
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.51788189
18* MYB_26560356_Chip-Seq_TH1_Human2.47009124
19* TCF7_22412390_ChIP-Seq_EML_Mouse2.42768526
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.42028204
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.37801292
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.37256455
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.31346067
24VDR_24763502_ChIP-Seq_THP-1_Human2.30818720
25CIITA_25753668_ChIP-Seq_RAJI_Human2.27011083
26* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.25411688
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.15521021
28STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13019891
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.06874510
30* SPI1_23547873_ChIP-Seq_NB4_Human2.06143209
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.03344630
32* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.01295844
33* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99186083
34* KDM2B_26808549_Chip-Seq_DND41_Human1.97038402
35* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92363902
36* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92238047
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91284941
38SPI1_23127762_ChIP-Seq_K562_Human1.88551533
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87467631
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.86807237
41* MAF_26560356_Chip-Seq_TH2_Human1.84812883
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.83334401
43* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82889671
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81497283
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79152180
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.72839082
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69261448
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68265666
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67280288
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62546107
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61772225
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60666120
53* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58018308
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55395527
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47745635
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46272813
57GATA3_27048872_Chip-Seq_THYMUS_Human1.46016000
58GATA1_22025678_ChIP-Seq_K562_Human1.39304258
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.36645192
60VDR_24787735_ChIP-Seq_THP-1_Human1.35789586
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33310908
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.33025984
63* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32726642
64PU.1_20513432_ChIP-Seq_Bcells_Mouse1.32553280
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30767077
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30552931
67* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30306215
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29044206
69* ELK3_25401928_ChIP-Seq_HUVEC_Human1.27182113
70* KDM2B_26808549_Chip-Seq_JURKAT_Human1.25345517
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24533001
72RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.22969930
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20140766
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20043522
75* RARB_27405468_Chip-Seq_BRAIN_Mouse1.18278201
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15522002
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14647901
78BCOR_27268052_Chip-Seq_Bcells_Human1.12699840
79GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12530976
80* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11247231
81* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10273506
82FOXP3_21729870_ChIP-Seq_TREG_Human1.09014639
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08342332
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07478276
85PU_27001747_Chip-Seq_BMDM_Mouse1.06383173
86* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06243107
87LXR_22292898_ChIP-Seq_THP-1_Human1.06228080
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06165328
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05979075
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05869870
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03185237
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02717800
93* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02494603
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.01683763
95FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.98856926
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98568192
97SMAD_19615063_ChIP-ChIP_OVARY_Human0.97801810
98* SA1_27219007_Chip-Seq_ERYTHROID_Human0.97551119
99BCL6_27268052_Chip-Seq_Bcells_Human0.97381806
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96970787
101* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96892027
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96557485
103* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96444910
104* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96350945
105GATA3_26560356_Chip-Seq_TH2_Human0.95526840
106E2F1_21310950_ChIP-Seq_MCF-7_Human0.92740783
107DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90246939
108HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90069388
109GATA2_19941826_ChIP-Seq_K562_Human0.87652201
110* NCOR1_26117541_ChIP-Seq_K562_Human0.86899662
111GATA1_19941826_ChIP-Seq_K562_Human0.85301726
112BP1_19119308_ChIP-ChIP_Hs578T_Human0.85180928
113P68_20966046_ChIP-Seq_HELA_Human0.85108801
114SPI1_20517297_ChIP-Seq_HL60_Human0.84601177
115MYC_19079543_ChIP-ChIP_MESCs_Mouse0.83317229
116VDR_23849224_ChIP-Seq_CD4+_Human0.82847996
117* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82648877
118SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.82119218
119SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.79629116
120* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.79365601
121P300_27268052_Chip-Seq_Bcells_Human0.77115917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy4.38991925
2MP0003763_abnormal_thymus_physiology3.76987597
3MP0002396_abnormal_hematopoietic_system3.63235522
4MP0001835_abnormal_antigen_presentation3.41213663
5MP0001800_abnormal_humoral_immune3.37587947
6MP0001790_abnormal_immune_system3.05756037
7MP0005387_immune_system_phenotype3.05756037
8MP0000685_abnormal_immune_system3.04572944
9MP0003303_peritoneal_inflammation2.93883517
10MP0002398_abnormal_bone_marrow2.87871496
11MP0005671_abnormal_response_to2.84852103
12MP0002420_abnormal_adaptive_immunity2.74546141
13MP0002452_abnormal_antigen_presenting2.70260814
14MP0001819_abnormal_immune_cell2.68552278
15MP0002723_abnormal_immune_serum2.60570015
16MP0005000_abnormal_immune_tolerance2.49889320
17MP0000716_abnormal_immune_system2.49314643
18MP0004808_abnormal_hematopoietic_stem2.45737739
19MP0000689_abnormal_spleen_morphology2.40191942
20MP0002722_abnormal_immune_system2.31376813
21MP0000703_abnormal_thymus_morphology2.23976684
22MP0005025_abnormal_response_to2.18970090
23MP0009785_altered_susceptibility_to2.16485667
24MP0002429_abnormal_blood_cell2.06965435
25MP0001873_stomach_inflammation2.05989715
26* MP0005464_abnormal_platelet_physiology2.05263416
27MP0002166_altered_tumor_susceptibility2.03153229
28MP0002419_abnormal_innate_immunity2.02175254
29MP0003436_decreased_susceptibility_to1.99041156
30MP0002405_respiratory_system_inflammati1.85624344
31MP0005174_abnormal_tail_pigmentation1.82899566
32MP0009278_abnormal_bone_marrow1.79755624
33MP0008260_abnormal_autophagy1.77036408
34MP0005409_darkened_coat_color1.73321487
35MP0000465_gastrointestinal_hemorrhage1.72781063
36MP0001545_abnormal_hematopoietic_system1.72690193
37MP0005397_hematopoietic_system_phenotyp1.72690193
38MP0003300_gastrointestinal_ulcer1.72089427
39MP0010155_abnormal_intestine_physiology1.70647739
40MP0003866_abnormal_defecation1.70350753
41MP0009333_abnormal_splenocyte_physiolog1.70055548
42MP0002006_tumorigenesis1.62507590
43MP0002148_abnormal_hypersensitivity_rea1.57598527
44MP0004381_abnormal_hair_follicle1.53961140
45MP0010094_abnormal_chromosome_stability1.46521316
46MP0003828_pulmonary_edema1.45465818
47MP0001845_abnormal_inflammatory_respons1.44640306
48MP0002009_preneoplasia1.37988363
49MP0001853_heart_inflammation1.37106208
50MP0003111_abnormal_nucleus_morphology1.29068064
51MP0008874_decreased_physiological_sensi1.28650824
52MP0008961_abnormal_basal_metabolism1.27748209
53MP0004859_abnormal_synaptic_plasticity1.26521093
54MP0008057_abnormal_DNA_replication1.20686654
55MP0005451_abnormal_body_composition1.19085864
56MP0000490_abnormal_crypts_of1.18527836
57MP0002019_abnormal_tumor_incidence1.18416632
58MP0005075_abnormal_melanosome_morpholog1.17502743
59MP0003787_abnormal_imprinting1.14988002
60MP0003077_abnormal_cell_cycle1.13518484
61MP0003724_increased_susceptibility_to1.12485444
62MP0004947_skin_inflammation1.10035209
63MP0000015_abnormal_ear_pigmentation1.09561510
64MP0002998_abnormal_bone_remodeling1.08261035
65MP0001986_abnormal_taste_sensitivity1.07636721
66MP0008058_abnormal_DNA_repair1.07310385
67MP0004883_abnormal_blood_vessel1.07214370
68MP0002095_abnormal_skin_pigmentation1.00814615
69MP0002138_abnormal_hepatobiliary_system0.99951996
70MP0005058_abnormal_lysosome_morphology0.96550522
71MP0001529_abnormal_vocalization0.95033815
72MP0003693_abnormal_embryo_hatching0.92402101
73MP0002132_abnormal_respiratory_system0.90525675
74MP0002933_joint_inflammation0.89086413
75MP0004510_myositis0.87782663
76MP0002277_abnormal_respiratory_mucosa0.87736443
77MP0004130_abnormal_muscle_cell0.87601396
78MP0008569_lethality_at_weaning0.85492405
79MP0008469_abnormal_protein_level0.84737037
80MP0009745_abnormal_behavioral_response0.84095735
81MP0000858_altered_metastatic_potential0.83974908
82MP0003172_abnormal_lysosome_physiology0.79326311
83MP0005310_abnormal_salivary_gland0.79322416
84MP0002909_abnormal_adrenal_gland0.78799078
85MP0008004_abnormal_stomach_pH0.76078869
86MP0003635_abnormal_synaptic_transmissio0.75309682
87MP0003656_abnormal_erythrocyte_physiolo0.75179756
88MP0003690_abnormal_glial_cell0.74735801
89MP0005423_abnormal_somatic_nervous0.74291329
90MP0005390_skeleton_phenotype0.73029615
91MP0003075_altered_response_to0.71085859
92MP0008877_abnormal_DNA_methylation0.70190616
93MP0005164_abnormal_response_to0.68396064
94MP0001663_abnormal_digestive_system0.65433387
95MP0000313_abnormal_cell_death0.61493594
96MP0001533_abnormal_skeleton_physiology0.60171815
97MP0009765_abnormal_xenobiotic_induced0.59505809
98MP0009764_decreased_sensitivity_to0.59041447
99MP0002083_premature_death0.58119335
100MP0003183_abnormal_peptide_metabolism0.57988216
101MP0003795_abnormal_bone_structure0.57973225
102MP0005166_decreased_susceptibility_to0.57866259
103MP0001851_eye_inflammation0.55306695
104MP0001188_hyperpigmentation0.54789470
105MP0008873_increased_physiological_sensi0.54519916
106MP0004185_abnormal_adipocyte_glucose0.53428772
107MP0008995_early_reproductive_senescence0.52231057
108MP0003091_abnormal_cell_migration0.52142750
109MP0003045_fibrosis0.51583525
110MP0004957_abnormal_blastocyst_morpholog0.51457051
111MP0005645_abnormal_hypothalamus_physiol0.51121499
112MP0003191_abnormal_cellular_cholesterol0.51101925
113MP0002063_abnormal_learning/memory/cond0.50920269
114MP0005381_digestive/alimentary_phenotyp0.50616532
115MP0002693_abnormal_pancreas_physiology0.50559731
116MP0003448_altered_tumor_morphology0.50499210
117MP0000604_amyloidosis0.50435819
118MP0002928_abnormal_bile_duct0.50041101
119MP0001486_abnormal_startle_reflex0.49213244
120MP0005535_abnormal_body_temperature0.47111085
121MP0000249_abnormal_blood_vessel0.45712321
122MP0008872_abnormal_physiological_respon0.45115280
123MP0003646_muscle_fatigue0.44806131
124MP0006082_CNS_inflammation0.44786071
125MP0002572_abnormal_emotion/affect_behav0.44525029
126MP0009763_increased_sensitivity_to0.44269699
127MP0003221_abnormal_cardiomyocyte_apopto0.41926047
128MP0009115_abnormal_fat_cell0.41177120
129MP0005388_respiratory_system_phenotype0.39890356
130MP0002133_abnormal_respiratory_system0.39890356

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.07840942
2Panhypogammaglobulinemia (HP:0003139)5.22682865
3Cellulitis (HP:0100658)4.84903969
4Chronic otitis media (HP:0000389)4.81688913
5Papilloma (HP:0012740)4.65072882
6Verrucae (HP:0200043)4.65072882
7Recurrent viral infections (HP:0004429)4.64710512
8IgM deficiency (HP:0002850)4.60861759
9Abnormality of macrophages (HP:0004311)4.56078015
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.53892060
11Recurrent bronchitis (HP:0002837)4.53021168
12T lymphocytopenia (HP:0005403)4.49957092
13Meningitis (HP:0001287)4.40396321
14Abnormality of B cell number (HP:0010975)4.23963626
15B lymphocytopenia (HP:0010976)4.23963626
16Abnormality of T cell number (HP:0011839)4.20690964
17Orchitis (HP:0100796)4.16954521
18Recurrent gram-negative bacterial infections (HP:0005420)3.97911041
19Retrobulbar optic neuritis (HP:0100654)3.97801132
20Optic neuritis (HP:0100653)3.97801132
21Recurrent fungal infections (HP:0002841)3.90055330
22Gastrointestinal infarctions (HP:0005244)3.83070462
23Abnormality of T cells (HP:0002843)3.75046597
24Thyroiditis (HP:0100646)3.72082248
25Gastrointestinal inflammation (HP:0004386)3.68233600
26Inflammation of the large intestine (HP:0002037)3.66401971
27Recurrent abscess formation (HP:0002722)3.62233630
28Chronic sinusitis (HP:0011109)3.43501444
29Abnormality of the fingertips (HP:0001211)3.40874568
30Chronic mucocutaneous candidiasis (HP:0002728)3.35970010
31Recurrent cutaneous fungal infections (HP:0011370)3.35970010
32Spontaneous hematomas (HP:0007420)3.34280553
33Lymphopenia (HP:0001888)3.33941185
34Colitis (HP:0002583)3.33653185
35Abnormality of cells of the lymphoid lineage (HP:0012140)3.23558800
36Recurrent sinusitis (HP:0011108)3.20280601
37Thrombocytosis (HP:0001894)3.18597483
38Acute lymphatic leukemia (HP:0006721)3.14514517
39Severe combined immunodeficiency (HP:0004430)3.13523923
40Gingivitis (HP:0000230)2.98322581
41Eosinophilia (HP:0001880)2.97828372
42Hypochromic microcytic anemia (HP:0004840)2.96449668
43Hypochromic anemia (HP:0001931)2.96384559
44Combined immunodeficiency (HP:0005387)2.95610461
45Abnormality of T cell physiology (HP:0011840)2.94930459
46Nasal polyposis (HP:0100582)2.94534388
47Pustule (HP:0200039)2.94435204
48Papilledema (HP:0001085)2.93487675
49Recurrent bacterial skin infections (HP:0005406)2.92638206
50Gastrointestinal stroma tumor (HP:0100723)2.90271540
51IgG deficiency (HP:0004315)2.90072082
52Keratoconjunctivitis sicca (HP:0001097)2.89721676
53Urticaria (HP:0001025)2.87577639
54Increased IgE level (HP:0003212)2.85799443
55Mediastinal lymphadenopathy (HP:0100721)2.85639636
56Granulocytopenia (HP:0001913)2.84805978
57Abnormality of the nasal mucosa (HP:0000433)2.80006659
58Sepsis (HP:0100806)2.79473788
59Hypoplasia of the thymus (HP:0000778)2.79029704
60Basal cell carcinoma (HP:0002671)2.77796493
61Elevated erythrocyte sedimentation rate (HP:0003565)2.77372435
62Chronic obstructive pulmonary disease (HP:0006510)2.76945382
63Obstructive lung disease (HP:0006536)2.76945382
64Eczematoid dermatitis (HP:0000976)2.74981231
65Autoimmune thrombocytopenia (HP:0001973)2.73523202
66Gingival bleeding (HP:0000225)2.72705534
67Keratoconjunctivitis (HP:0001096)2.69135751
68Increased IgM level (HP:0003496)2.57957585
69* Prolonged bleeding time (HP:0003010)2.57314841
70Vasculitis (HP:0002633)2.56974840
71Recurrent skin infections (HP:0001581)2.54874996
72Osteomyelitis (HP:0002754)2.53785600
73Bronchitis (HP:0012387)2.53684873
74Myositis (HP:0100614)2.53330889
75Episodic fever (HP:0001954)2.53172380
76Recurrent otitis media (HP:0000403)2.50521589
77Autoimmune hemolytic anemia (HP:0001890)2.50054738
78Lymphoma (HP:0002665)2.45471972
79Abnormality of eosinophils (HP:0001879)2.45053947
80Encephalitis (HP:0002383)2.44538530
81Chest pain (HP:0100749)2.44328535
82Viral hepatitis (HP:0006562)2.43356285
83Pulmonary embolism (HP:0002204)2.41721343
84Hypergammaglobulinemia (HP:0010702)2.34056131
85Arterial thrombosis (HP:0004420)2.33419136
86Microcytic anemia (HP:0001935)2.28472353
87Limb hypertonia (HP:0002509)2.26245268
88Slow saccadic eye movements (HP:0000514)2.22639496
89Purpura (HP:0000979)2.20845539
90Anorexia (HP:0002039)2.19809562
91Skin rash (HP:0000988)2.19285839
92Recurrent pneumonia (HP:0006532)2.14341253
93Leukocytosis (HP:0001974)2.14319634
94Stomatitis (HP:0010280)2.13577510
95Emphysema (HP:0002097)2.11241350
96Hyperacusis (HP:0010780)2.10955951
97Petechiae (HP:0000967)2.09638884
98Abnormality of the pleura (HP:0002103)2.07459646
99Annular pancreas (HP:0001734)2.07418491
100Abnormality of the prostate (HP:0008775)2.07161022
101Recurrent lower respiratory tract infections (HP:0002783)2.04626012
102Reticulocytopenia (HP:0001896)2.03058128
103Abnormality of DNA repair (HP:0003254)2.01354285
104* Epistaxis (HP:0000421)2.00938109
105Hemoptysis (HP:0002105)1.99321626
106Poikiloderma (HP:0001029)1.98684344
107Skin ulcer (HP:0200042)1.97514993
108Vertebral arch anomaly (HP:0008438)1.96345831
109Increased serum ferritin (HP:0003281)1.95815589
110Restrictive lung disease (HP:0002091)1.94184428
111IgA deficiency (HP:0002720)1.93463694
112Acute hepatic failure (HP:0006554)1.92300100
113Abnormal number of erythroid precursors (HP:0012131)1.91946849
114Neutropenia (HP:0001875)1.90453427
115Abnormality of cells of the erythroid lineage (HP:0012130)1.90145575
116Abnormality of the intervertebral disk (HP:0005108)1.89143589
117Seborrheic dermatitis (HP:0001051)1.88980032
118Joint swelling (HP:0001386)1.88579051
119Abnormal platelet volume (HP:0011876)1.87145714
120Glomerulopathy (HP:0100820)1.86914454
121Gangrene (HP:0100758)1.86891119
122Resting tremor (HP:0002322)1.86787836
123Abnormality of iron homeostasis (HP:0011031)1.85960266
124Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.82375886
125Hepatosplenomegaly (HP:0001433)1.82146468
126Abnormality of oral frenula (HP:0000190)1.82043919
127Impaired platelet aggregation (HP:0003540)1.76372335
128Abnormal platelet function (HP:0011869)1.76372335
129Hypoproteinemia (HP:0003075)1.75214764
130Leukopenia (HP:0001882)1.73670158
131Long eyelashes (HP:0000527)1.73459264
132Pulmonary infiltrates (HP:0002113)1.72555073
133Small epiphyses (HP:0010585)1.71866762

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.71934391
2MAP3K103.35923709
3GRK63.10567817
4EEF2K3.02511708
5SIK23.00935471
6FES2.71526961
7BTK2.48452785
8TXK2.19488743
9SYK2.18495886
10RIPK42.09991361
11STK102.00169405
12TEC1.99895509
13MAP3K131.98825130
14ITK1.93403538
15BLK1.91759098
16TNK21.81514421
17IRAK41.78757739
18JAK31.78502584
19ZAP701.77105551
20HCK1.69333358
21TAOK31.61729702
22TYK21.61403980
23CLK11.58053893
24IKBKE1.56234961
25EPHA41.45999264
26LRRK21.40288669
27PKN21.36458348
28CSF1R1.33792515
29EPHB11.33672161
30KIT1.32772450
31LCK1.28146880
32PRKD21.25962264
33MAP3K111.23714112
34PRKCH1.22634031
35MAP3K31.20929138
36MARK31.18253183
37JAK11.09247791
38NLK1.07721045
39LYN1.07667981
40CSK1.06142271
41FGR1.06087842
42CDK41.05854015
43PASK1.03142941
44PIM11.02741294
45MAP2K31.01809298
46MAP3K11.00030579
47MAP3K140.99698706
48NEK20.99091472
49MAPK120.98884165
50MARK20.96254451
51TAOK10.95905739
52MAP3K70.93882810
53ERN10.89290082
54SMG10.88375892
55ALK0.87627261
56FLT30.84409025
57BMPR20.83001408
58MAPK40.82343884
59IRAK30.82146449
60STK40.82008407
61PRKCQ0.80986238
62CDC42BPA0.77267764
63FGFR30.76115855
64YES10.75333768
65SIK10.73319302
66BRD40.73143694
67KDR0.72394938
68KSR20.72115398
69CDK120.71167452
70SIK30.70817129
71PDK10.69467936
72CAMKK20.67907314
73SGK30.66308934
74PTK60.64535682
75TRIB30.64526813
76DAPK10.63439334
77HIPK20.62653500
78IKBKB0.61755853
79CDC70.61742940
80IRAK20.60982412
81FGFR40.60418475
82IRAK10.60214560
83MAPK70.58532995
84TAOK20.58332725
85TNIK0.58116383
86DYRK1B0.57865122
87RPS6KB20.57274146
88ATR0.56057678
89RPS6KA60.55386912
90CDK190.54704385
91TBK10.53708058
92MAPK110.53645017
93CAMKK10.52407905
94STK240.52032558
95RPS6KL10.50075035
96RPS6KC10.50075035
97JAK20.49693332
98MAP2K20.49610339
99TGFBR20.49289309
100NTRK20.47139814
101CAMK10.47082690
102STK110.46715406
103CDK60.46543063
104PIK3CG0.45753112
105RAF10.45741954
106SGK20.45513470
107RET0.44403032
108MATK0.43043449
109STK380.42515964
110FYN0.42382753
111PTK2B0.41862366
112BMX0.38423439
113RPS6KA20.38044608
114PRPF4B0.37304029
115MAP3K60.37065358
116EIF2AK30.34367140
117TRPM70.31457058
118TTN0.30188241
119MELK0.28791494
120ABL10.27982887
121CAMK40.27978914
122MAPKAPK20.27342301
123MAP3K80.27020500
124PRKD10.25508452
125BRSK10.25308416
126CHEK10.24794737
127TESK20.24393396
128PDPK10.22602146
129CDK20.22224635
130MAP2K60.21903171
131MAPK30.21725792
132CDK90.21647133

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.35983793
2B cell receptor signaling pathway_Homo sapiens_hsa046623.42941888
3Allograft rejection_Homo sapiens_hsa053302.67212717
4Graft-versus-host disease_Homo sapiens_hsa053322.65205335
5Autoimmune thyroid disease_Homo sapiens_hsa053202.56299833
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.49325682
7DNA replication_Homo sapiens_hsa030302.38078862
8T cell receptor signaling pathway_Homo sapiens_hsa046602.25552361
9Staphylococcus aureus infection_Homo sapiens_hsa051502.14948361
10Olfactory transduction_Homo sapiens_hsa047402.07441468
11Type I diabetes mellitus_Homo sapiens_hsa049401.95560443
12Hematopoietic cell lineage_Homo sapiens_hsa046401.90908567
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.86828586
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.79178803
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.75979728
16Mismatch repair_Homo sapiens_hsa034301.74421730
17Leishmaniasis_Homo sapiens_hsa051401.73354320
18Non-homologous end-joining_Homo sapiens_hsa034501.72047161
19Osteoclast differentiation_Homo sapiens_hsa043801.71929602
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.68033575
21Base excision repair_Homo sapiens_hsa034101.65915496
22Measles_Homo sapiens_hsa051621.58904841
23Asthma_Homo sapiens_hsa053101.58800909
24Non-small cell lung cancer_Homo sapiens_hsa052231.56762546
25* Chemokine signaling pathway_Homo sapiens_hsa040621.53218717
26Acute myeloid leukemia_Homo sapiens_hsa052211.51743024
27Morphine addiction_Homo sapiens_hsa050321.45486034
28Antigen processing and presentation_Homo sapiens_hsa046121.40397305
29Malaria_Homo sapiens_hsa051441.37027589
30Ribosome_Homo sapiens_hsa030101.32590010
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30832706
32Herpes simplex infection_Homo sapiens_hsa051681.24797612
33* Platelet activation_Homo sapiens_hsa046111.23863223
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19583038
35Chronic myeloid leukemia_Homo sapiens_hsa052201.17933532
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.16346646
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14979241
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.10596009
39Homologous recombination_Homo sapiens_hsa034401.10579150
40Spliceosome_Homo sapiens_hsa030401.09980243
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04647038
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04539374
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03675018
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.02303696
45Hepatitis B_Homo sapiens_hsa051610.98107600
46Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97469621
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94609505
48Legionellosis_Homo sapiens_hsa051340.93510822
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93455490
50Hepatitis C_Homo sapiens_hsa051600.93403478
51Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93177711
52Long-term potentiation_Homo sapiens_hsa047200.91547336
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91036417
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90231340
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90213774
56African trypanosomiasis_Homo sapiens_hsa051430.89895333
57Cocaine addiction_Homo sapiens_hsa050300.89322026
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88370233
59Phagosome_Homo sapiens_hsa041450.86640048
60Cholinergic synapse_Homo sapiens_hsa047250.86483627
61Fanconi anemia pathway_Homo sapiens_hsa034600.85594222
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84301276
63Renal cell carcinoma_Homo sapiens_hsa052110.83418782
64VEGF signaling pathway_Homo sapiens_hsa043700.80929309
65HTLV-I infection_Homo sapiens_hsa051660.80265102
66Rheumatoid arthritis_Homo sapiens_hsa053230.76910731
67Influenza A_Homo sapiens_hsa051640.76783067
68Colorectal cancer_Homo sapiens_hsa052100.74441076
69Pancreatic cancer_Homo sapiens_hsa052120.73539664
70Circadian entrainment_Homo sapiens_hsa047130.72936684
71Prolactin signaling pathway_Homo sapiens_hsa049170.72792195
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70890006
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.70545941
74Endocytosis_Homo sapiens_hsa041440.69812692
75Lysine degradation_Homo sapiens_hsa003100.69736318
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69082571
77Shigellosis_Homo sapiens_hsa051310.68897880
78Tuberculosis_Homo sapiens_hsa051520.68757506
79Toxoplasmosis_Homo sapiens_hsa051450.68090071
80Glioma_Homo sapiens_hsa052140.66888598
81Apoptosis_Homo sapiens_hsa042100.65933650
82Epstein-Barr virus infection_Homo sapiens_hsa051690.65804976
83Viral myocarditis_Homo sapiens_hsa054160.65767068
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.65218165
85Dopaminergic synapse_Homo sapiens_hsa047280.64033474
86mRNA surveillance pathway_Homo sapiens_hsa030150.63386116
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.63002390
88Oxytocin signaling pathway_Homo sapiens_hsa049210.62623813
89Calcium signaling pathway_Homo sapiens_hsa040200.62249103
90Amphetamine addiction_Homo sapiens_hsa050310.62139387
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61881247
92GnRH signaling pathway_Homo sapiens_hsa049120.60809097
93Renin secretion_Homo sapiens_hsa049240.59713974
94Nucleotide excision repair_Homo sapiens_hsa034200.59370309
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58979399
96Inositol phosphate metabolism_Homo sapiens_hsa005620.58609607
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58545755
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58102970
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57558344
100Glutamatergic synapse_Homo sapiens_hsa047240.55712707
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54776126
102Alcoholism_Homo sapiens_hsa050340.54537606
103Choline metabolism in cancer_Homo sapiens_hsa052310.54470697
104Regulation of autophagy_Homo sapiens_hsa041400.54365421
105Endometrial cancer_Homo sapiens_hsa052130.54351344
106Salmonella infection_Homo sapiens_hsa051320.53782792
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.52980996
108Dorso-ventral axis formation_Homo sapiens_hsa043200.52346525
109Insulin resistance_Homo sapiens_hsa049310.52321658
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52242444
111* MAPK signaling pathway_Homo sapiens_hsa040100.52235110
112FoxO signaling pathway_Homo sapiens_hsa040680.52199881
113Gastric acid secretion_Homo sapiens_hsa049710.49478107
114Salivary secretion_Homo sapiens_hsa049700.49268352
115cAMP signaling pathway_Homo sapiens_hsa040240.48050173
116Pertussis_Homo sapiens_hsa051330.47901367
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47882239
118RNA degradation_Homo sapiens_hsa030180.45759595
119TNF signaling pathway_Homo sapiens_hsa046680.45739845
120ErbB signaling pathway_Homo sapiens_hsa040120.45234509
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44638892
122Viral carcinogenesis_Homo sapiens_hsa052030.44310623
123mTOR signaling pathway_Homo sapiens_hsa041500.44209137
124Prostate cancer_Homo sapiens_hsa052150.43664665
125Notch signaling pathway_Homo sapiens_hsa043300.43224126
126Cell cycle_Homo sapiens_hsa041100.42850548
127Other glycan degradation_Homo sapiens_hsa005110.42530135
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41573793
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40931066
130Thyroid cancer_Homo sapiens_hsa052160.40884081
131HIF-1 signaling pathway_Homo sapiens_hsa040660.40741959
132Small cell lung cancer_Homo sapiens_hsa052220.40530586
133* Rap1 signaling pathway_Homo sapiens_hsa040150.40460818
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40254454
135Type II diabetes mellitus_Homo sapiens_hsa049300.38921205
136Glycosaminoglycan degradation_Homo sapiens_hsa005310.38811907
137Amoebiasis_Homo sapiens_hsa051460.34003448
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32947633

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