RASGRP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukocyte aggregation (GO:0070486)6.70889136
2cellular extravasation (GO:0045123)6.55484359
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.24362002
4response to peptidoglycan (GO:0032494)5.82063693
5leukocyte migration involved in inflammatory response (GO:0002523)5.69652815
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.39915709
7positive regulation of mast cell activation (GO:0033005)5.15343881
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.05588692
9negative regulation of cell killing (GO:0031342)5.05588692
10regulation of B cell receptor signaling pathway (GO:0050855)5.00213462
11respiratory burst (GO:0045730)4.98397389
12neutrophil activation involved in immune response (GO:0002283)4.88702108
13defense response to fungus (GO:0050832)4.87850489
14production of molecular mediator involved in inflammatory response (GO:0002532)4.86851923
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.82219096
16neutrophil mediated immunity (GO:0002446)4.73429551
17positive regulation of mast cell degranulation (GO:0043306)4.65162807
18positive regulation of mast cell activation involved in immune response (GO:0033008)4.65162807
19regulation of mast cell degranulation (GO:0043304)4.59845627
20modulation by symbiont of host defense response (GO:0052031)4.58170002
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.58170002
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.58170002
23positive regulation by organism of defense response of other organism involved in symbiotic interact4.58170002
24modulation by symbiont of host immune response (GO:0052553)4.58170002
25positive regulation by symbiont of host defense response (GO:0052509)4.58170002
26detection of external biotic stimulus (GO:0098581)4.55382737
27negative regulation of lymphocyte mediated immunity (GO:0002707)4.49288708
28detection of molecule of bacterial origin (GO:0032490)4.42321145
29neutrophil activation (GO:0042119)4.41935575
30regulation of mast cell activation (GO:0033003)4.39194115
31response to fungus (GO:0009620)4.38255107
32regulation of myeloid leukocyte mediated immunity (GO:0002886)4.35565741
33regulation of mast cell activation involved in immune response (GO:0033006)4.30590322
34leukotriene metabolic process (GO:0006691)4.24185720
35response to interleukin-15 (GO:0070672)4.21187544
36regulation of gamma-delta T cell activation (GO:0046643)4.20622124
37negative regulation of interleukin-12 production (GO:0032695)4.18989232
38microglial cell activation (GO:0001774)4.18434154
39regulation of leukocyte degranulation (GO:0043300)4.17715740
40positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.16209417
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.12124555
42response to host immune response (GO:0052572)4.12124555
43granulocyte activation (GO:0036230)4.09140549
44immunoglobulin mediated immune response (GO:0016064)4.06958344
45detection of biotic stimulus (GO:0009595)4.03542374
46negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.99232358
47superoxide anion generation (GO:0042554)3.96430230
48neutrophil chemotaxis (GO:0030593)3.93395957
49negative regulation of leukocyte mediated immunity (GO:0002704)3.90982589
50cellular response to interleukin-15 (GO:0071350)3.90234788
51neutrophil migration (GO:1990266)3.81343208
52macrophage activation (GO:0042116)3.80263009
53negative regulation of T cell mediated immunity (GO:0002710)3.80100957
54lipoxygenase pathway (GO:0019372)3.75789838
55positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.73223624
56response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.71451623
57response to host (GO:0075136)3.71451623
58response to host defenses (GO:0052200)3.71451623
59Arp2/3 complex-mediated actin nucleation (GO:0034314)3.71381024
60leukotriene biosynthetic process (GO:0019370)3.68552966
61regulation of gamma-delta T cell differentiation (GO:0045586)3.58465506
62macrophage differentiation (GO:0030225)3.45811488
63positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.45648295
64myeloid leukocyte mediated immunity (GO:0002444)3.45490208
65antigen processing and presentation via MHC class Ib (GO:0002475)3.42015156
66negative regulation of phagocytosis (GO:0050765)3.41647281
67regulation of B cell differentiation (GO:0045577)3.41556271
68positive regulation of leukocyte degranulation (GO:0043302)3.41231297
69positive regulation of gamma-delta T cell activation (GO:0046645)3.40700537
70regulation of regulated secretory pathway (GO:1903305)3.35218039
71chronic inflammatory response (GO:0002544)3.35195221
72granulocyte migration (GO:0097530)3.34860784
73negative regulation of granulocyte differentiation (GO:0030853)3.34318823
74tolerance induction (GO:0002507)3.33978277
75B cell mediated immunity (GO:0019724)3.33769817
76positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.33736927
77negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.30358540
78leukocyte cell-cell adhesion (GO:0007159)3.29622952
79type I interferon signaling pathway (GO:0060337)3.29310778
80cellular response to type I interferon (GO:0071357)3.29310778
81response to muramyl dipeptide (GO:0032495)3.29050441
82response to type I interferon (GO:0034340)3.27426113
83granulocyte chemotaxis (GO:0071621)3.27292886
84regulation of tolerance induction (GO:0002643)3.26440076
85regulation of T cell tolerance induction (GO:0002664)3.25786405
86negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.22580679
87negative regulation of T-helper cell differentiation (GO:0045623)3.22580679
88disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.20600487
89killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.20600487
90detection of other organism (GO:0098543)3.15066601
91negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.14810536
92detection of bacterium (GO:0016045)3.12644826
93positive regulation of B cell differentiation (GO:0045579)3.11815662
94positive regulation of antigen processing and presentation (GO:0002579)3.10215071
95regulation of T cell mediated cytotoxicity (GO:0001914)3.08655341
96negative regulation of interleukin-1 production (GO:0032692)3.07708069
97macrophage activation involved in immune response (GO:0002281)3.05532910
98positive regulation of T cell mediated cytotoxicity (GO:0001916)3.05103885
99negative regulation of erythrocyte differentiation (GO:0045647)3.03941398
100hydrogen peroxide biosynthetic process (GO:0050665)3.03332715
101negative regulation of cytokine production involved in immune response (GO:0002719)3.02807262
102negative regulation of alpha-beta T cell activation (GO:0046636)3.02766638
103negative regulation of interleukin-6 production (GO:0032715)3.02081952
104regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.01633700
105regulation of T-helper 2 cell differentiation (GO:0045628)3.01229159
106positive regulation of interferon-alpha production (GO:0032727)3.01066074
107negative regulation of innate immune response (GO:0045824)3.00187454
108negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.99317838
109regulation of natural killer cell mediated immunity (GO:0002715)2.98066120
110regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.98066120
111dendritic cell migration (GO:0036336)2.97413922
112actin nucleation (GO:0045010)2.97168414
113leukocyte mediated cytotoxicity (GO:0001909)2.96226208
114sequestering of metal ion (GO:0051238)2.92537991
115germinal center formation (GO:0002467)2.89521429
116regulation of interferon-beta biosynthetic process (GO:0045357)2.88153196
117myeloid cell activation involved in immune response (GO:0002275)2.86356940
118regulation of dendritic cell antigen processing and presentation (GO:0002604)2.86321846
119activated T cell proliferation (GO:0050798)2.86067541
120negative regulation of mast cell activation (GO:0033004)2.83252380
121regulation of antigen processing and presentation (GO:0002577)2.81009091
122B cell receptor signaling pathway (GO:0050853)2.80913294
123dendritic cell chemotaxis (GO:0002407)2.77092039
124regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.73571235
125adaptation of signaling pathway (GO:0023058)2.73196420
126reactive oxygen species biosynthetic process (GO:1903409)2.71466547
127mannose metabolic process (GO:0006013)2.69843438
128positive regulation of toll-like receptor signaling pathway (GO:0034123)2.66442988
129antigen processing and presentation of endogenous antigen (GO:0019883)2.65558319
130myeloid leukocyte migration (GO:0097529)2.65358379
131leukocyte degranulation (GO:0043299)2.63399653
132leukocyte chemotaxis (GO:0030595)2.59196849
133leukocyte mediated immunity (GO:0002443)2.58831283
134adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.53429829
135positive regulation of regulated secretory pathway (GO:1903307)2.53019499
136pinocytosis (GO:0006907)2.51760136
137regulation of interleukin-6 biosynthetic process (GO:0045408)2.51713902
138lymphocyte mediated immunity (GO:0002449)2.48793275
139defense response to protozoan (GO:0042832)2.48370217
140interferon-gamma-mediated signaling pathway (GO:0060333)2.44289996

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.93832729
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.92491643
3E2F7_22180533_ChIP-Seq_HELA_Human4.43920882
4* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.49804843
5MYB_21317192_ChIP-Seq_ERMYB_Mouse3.36916613
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.18356384
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.12144105
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.08018415
9* SPI1_23547873_ChIP-Seq_NB4_Human2.82036903
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.80582488
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.79871922
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.74129857
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.64616691
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57535582
15VDR_21846776_ChIP-Seq_THP-1_Human2.56608308
16* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.48719495
17* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.45553233
18BRD4_27068464_Chip-Seq_AML-cells_Mouse2.45205520
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.37425579
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.33710410
21* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.11156931
22SCL_19346495_ChIP-Seq_HPC-7_Human2.09667170
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08878345
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.07608863
25MYC_22102868_ChIP-Seq_BL_Human2.04884084
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.03949332
27* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03300916
28VDR_24763502_ChIP-Seq_THP-1_Human1.94731458
29VDR_24787735_ChIP-Seq_THP-1_Human1.92176487
30* MAF_26560356_Chip-Seq_TH1_Human1.91892575
31MYB_26560356_Chip-Seq_TH2_Human1.85322486
32* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.84778364
33* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81566031
34* SPI1_23127762_ChIP-Seq_K562_Human1.75929550
35UTX_26944678_Chip-Seq_JUKART_Human1.75613487
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.75463174
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68448988
38MYB_26560356_Chip-Seq_TH1_Human1.67180596
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64826940
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64510447
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61473244
42TCF7_22412390_ChIP-Seq_EML_Mouse1.54898824
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.54243687
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53581010
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.53016895
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52670377
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50923625
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50316742
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47907050
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46062275
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.44796705
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44551175
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41808672
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41060827
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40667852
56PU_27001747_Chip-Seq_BMDM_Mouse1.40557670
57MAF_26560356_Chip-Seq_TH2_Human1.39984671
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.39679777
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37539050
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36212345
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33588326
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32172729
63RUNX_20019798_ChIP-Seq_JUKART_Human1.31394916
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31384250
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.31106708
66* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29492016
67SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29395952
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24954253
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24020928
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22277235
71MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22176452
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22068107
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19915180
74* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19080190
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18760863
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16256146
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16247423
78GATA1_19941826_ChIP-Seq_K562_Human1.16162937
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15619008
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15307506
81MYC_18555785_ChIP-Seq_MESCs_Mouse1.15068049
82* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14639710
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.11554074
84* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11083252
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10443861
86BCOR_27268052_Chip-Seq_Bcells_Human1.07751729
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07316786
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07316786
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07316786
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06911631
91CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06422598
92VDR_23849224_ChIP-Seq_CD4+_Human1.04679451
93GATA1_22025678_ChIP-Seq_K562_Human1.04627448
94SPI1_20517297_ChIP-Seq_HL60_Human1.03986929
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03525419
96GATA2_21666600_ChIP-Seq_HMVEC_Human1.03362837
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02746139
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02713272
99NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02681007
100GATA1_19941827_ChIP-Seq_MEL_Mouse1.02439226
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02148618
102GATA3_27048872_Chip-Seq_THYMUS_Human1.01320731
103MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01287326
104KDM2B_26808549_Chip-Seq_JURKAT_Human1.00492940
105KDM2B_26808549_Chip-Seq_DND41_Human0.99913439
106KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95346830
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93631191
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93032689
109RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92426246
110E2F1_21310950_ChIP-Seq_MCF-7_Human0.92077644
111GATA3_26560356_Chip-Seq_TH2_Human0.91324140
112LXR_22292898_ChIP-Seq_THP-1_Human0.91269627
113* GATA2_19941826_ChIP-Seq_K562_Human0.91082639
114PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89899308
115FOXP3_21729870_ChIP-Seq_TREG_Human0.89857826
116ETS1_20019798_ChIP-Seq_JURKAT_Human0.89005719
117SMRT_27268052_Chip-Seq_Bcells_Human0.87746620
118MYC_19030024_ChIP-ChIP_MESCs_Mouse0.85854624
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.84398645
120NCOR1_26117541_ChIP-Seq_K562_Human0.84045605
121CIITA_25753668_ChIP-Seq_RAJI_Human0.84031652
122BCL6_27268052_Chip-Seq_Bcells_Human0.83991718
123RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.83563579
124NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80842916
125FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79150235
126P300_27268052_Chip-Seq_Bcells_Human0.78937804
127TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78553420

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.33043176
2MP0003436_decreased_susceptibility_to4.21657045
3MP0001835_abnormal_antigen_presentation3.33099598
4MP0009278_abnormal_bone_marrow3.13699621
5MP0002419_abnormal_innate_immunity3.09993243
6MP0009785_altered_susceptibility_to3.09772566
7MP0005025_abnormal_response_to2.75192451
8MP0002148_abnormal_hypersensitivity_rea2.70696725
9MP0005000_abnormal_immune_tolerance2.69923628
10MP0001790_abnormal_immune_system2.65247501
11MP0005387_immune_system_phenotype2.65247501
12MP0001800_abnormal_humoral_immune2.57834019
13MP0002452_abnormal_antigen_presenting2.46687240
14MP0001853_heart_inflammation2.38476232
15MP0000685_abnormal_immune_system2.36999486
16MP0001819_abnormal_immune_cell2.36024453
17MP0002420_abnormal_adaptive_immunity2.34866048
18MP0002405_respiratory_system_inflammati2.31382164
19MP0002723_abnormal_immune_serum2.29659362
20MP0002396_abnormal_hematopoietic_system2.29267267
21MP0003724_increased_susceptibility_to2.27422838
22MP0005671_abnormal_response_to2.12676570
23MP0005464_abnormal_platelet_physiology2.08215090
24MP0001545_abnormal_hematopoietic_system2.06137558
25MP0005397_hematopoietic_system_phenotyp2.06137558
26MP0001533_abnormal_skeleton_physiology2.00937668
27MP0000465_gastrointestinal_hemorrhage1.94314591
28MP0003693_abnormal_embryo_hatching1.91505089
29MP0004510_myositis1.90546724
30MP0002398_abnormal_bone_marrow1.90127773
31MP0005058_abnormal_lysosome_morphology1.89834615
32MP0000716_abnormal_immune_system1.83333528
33MP0000343_altered_response_to1.80303349
34MP0003183_abnormal_peptide_metabolism1.77287661
35MP0001845_abnormal_inflammatory_respons1.76319549
36MP0004808_abnormal_hematopoietic_stem1.74283613
37MP0005174_abnormal_tail_pigmentation1.72690033
38MP0009333_abnormal_splenocyte_physiolog1.72411465
39MP0006082_CNS_inflammation1.71343795
40MP0002277_abnormal_respiratory_mucosa1.67172973
41MP0010155_abnormal_intestine_physiology1.65571889
42MP0000689_abnormal_spleen_morphology1.62595296
43MP0000858_altered_metastatic_potential1.61524461
44MP0002722_abnormal_immune_system1.58674956
45MP0002429_abnormal_blood_cell1.55387995
46MP0003448_altered_tumor_morphology1.49814050
47MP0003300_gastrointestinal_ulcer1.48294185
48MP0004947_skin_inflammation1.47322859
49MP0001851_eye_inflammation1.46630650
50MP0003828_pulmonary_edema1.44624776
51MP0000490_abnormal_crypts_of1.43969248
52MP0003111_abnormal_nucleus_morphology1.43701511
53MP0002933_joint_inflammation1.39861218
54MP0008260_abnormal_autophagy1.37757774
55MP0003172_abnormal_lysosome_physiology1.33262333
56MP0005076_abnormal_cell_differentiation1.31582054
57MP0008469_abnormal_protein_level1.29492420
58MP0001873_stomach_inflammation1.29227052
59MP0001986_abnormal_taste_sensitivity1.28578089
60MP0009764_decreased_sensitivity_to1.24722569
61MP0003763_abnormal_thymus_physiology1.23754445
62MP0000015_abnormal_ear_pigmentation1.21867607
63MP0005310_abnormal_salivary_gland1.18710667
64MP0003075_altered_response_to1.14559652
65MP0003566_abnormal_cell_adhesion1.13427655
66MP0000703_abnormal_thymus_morphology1.13156612
67MP0000569_abnormal_digit_pigmentation1.12114781
68MP0009840_abnormal_foam_cell1.07540193
69MP0010094_abnormal_chromosome_stability1.06245829
70MP0005167_abnormal_blood-brain_barrier1.05147062
71MP0003866_abnormal_defecation1.04333644
72MP0005023_abnormal_wound_healing1.03071080
73MP0002132_abnormal_respiratory_system1.01939969
74MP0003077_abnormal_cell_cycle1.00131497
75MP0010307_abnormal_tumor_latency0.97813602
76MP0002166_altered_tumor_susceptibility0.97464387
77MP0004883_abnormal_blood_vessel0.96049098
78MP0003690_abnormal_glial_cell0.95412025
79MP0005390_skeleton_phenotype0.92750395
80MP0002006_tumorigenesis0.89583521
81MP0003806_abnormal_nucleotide_metabolis0.87192620
82MP0008004_abnormal_stomach_pH0.86668810
83MP0004957_abnormal_blastocyst_morpholog0.86287195
84MP0003453_abnormal_keratinocyte_physiol0.85036000
85MP0001663_abnormal_digestive_system0.83851979
86MP0008058_abnormal_DNA_repair0.83385529
87MP0002019_abnormal_tumor_incidence0.82633472
88MP0003045_fibrosis0.82375112
89MP0005166_decreased_susceptibility_to0.79318359
90MP0003191_abnormal_cellular_cholesterol0.79266272
91MP0005377_hearing/vestibular/ear_phenot0.78557247
92MP0003878_abnormal_ear_physiology0.78557247
93MP0004381_abnormal_hair_follicle0.78243739
94MP0010352_gastrointestinal_tract_polyps0.77466972
95MP0002837_dystrophic_cardiac_calcinosis0.76348138
96MP0002928_abnormal_bile_duct0.75891151
97MP0005083_abnormal_biliary_tract0.75655301
98MP0009763_increased_sensitivity_to0.75111829
99MP0004130_abnormal_muscle_cell0.73005029
100MP0005451_abnormal_body_composition0.72739011
101MP0005075_abnormal_melanosome_morpholog0.72248523
102MP0002138_abnormal_hepatobiliary_system0.71405225
103MP0000371_diluted_coat_color0.69818952
104MP0000249_abnormal_blood_vessel0.67876727
105MP0003656_abnormal_erythrocyte_physiolo0.67473979
106MP0002095_abnormal_skin_pigmentation0.67429237
107MP0005084_abnormal_gallbladder_morpholo0.67125712
108MP0000313_abnormal_cell_death0.61059252
109MP0002653_abnormal_ependyma_morphology0.60521938
110MP0003795_abnormal_bone_structure0.58911456
111MP0005319_abnormal_enzyme/_coenzyme0.58550072
112MP0009765_abnormal_xenobiotic_induced0.57611915
113MP0002693_abnormal_pancreas_physiology0.57296295
114MP0000604_amyloidosis0.57018285
115MP0002998_abnormal_bone_remodeling0.56753778
116MP0003638_abnormal_response/metabolism_0.56136231
117MP0005164_abnormal_response_to0.55946450
118MP0008874_decreased_physiological_sensi0.53216879
119MP0002332_abnormal_exercise_endurance0.49988247
120MP0000470_abnormal_stomach_morphology0.49230250
121MP0004484_altered_response_of0.49152156

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)8.11851693
2Eczematoid dermatitis (HP:0000976)7.40714284
3Recurrent bacterial skin infections (HP:0005406)7.00471512
4Recurrent gram-negative bacterial infections (HP:0005420)6.22200173
5Chronic obstructive pulmonary disease (HP:0006510)5.42193362
6Obstructive lung disease (HP:0006536)5.42193362
7Abnormality of macrophages (HP:0004311)5.07286018
8Recurrent fungal infections (HP:0002841)4.70693259
9Mediastinal lymphadenopathy (HP:0100721)4.67207815
10Hypochromic microcytic anemia (HP:0004840)4.58595076
11Gingivitis (HP:0000230)4.39176856
12Recurrent skin infections (HP:0001581)4.38003303
13Myositis (HP:0100614)4.35846952
14Stomatitis (HP:0010280)4.29955743
15Elevated erythrocyte sedimentation rate (HP:0003565)3.99408446
16Systemic lupus erythematosus (HP:0002725)3.97045553
17IgM deficiency (HP:0002850)3.91635125
18Hypochromic anemia (HP:0001931)3.85011731
19Vacuolated lymphocytes (HP:0001922)3.70861978
20Episodic fever (HP:0001954)3.56962412
21Pustule (HP:0200039)3.54806735
22Meningitis (HP:0001287)3.53889757
23Cellulitis (HP:0100658)3.48300884
24Recurrent cutaneous fungal infections (HP:0011370)3.42389071
25Chronic mucocutaneous candidiasis (HP:0002728)3.42389071
26Orchitis (HP:0100796)3.38314560
27Urticaria (HP:0001025)3.30647592
28Petechiae (HP:0000967)3.24142964
29Prolonged bleeding time (HP:0003010)3.15319902
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.11834065
31Spontaneous hematomas (HP:0007420)3.11782856
32Optic neuritis (HP:0100653)3.05487355
33Retrobulbar optic neuritis (HP:0100654)3.05487355
34Peritonitis (HP:0002586)3.04414550
35Recurrent viral infections (HP:0004429)3.03240789
36Anorexia (HP:0002039)3.02807701
37Inflammation of the large intestine (HP:0002037)2.90095476
38Cheilitis (HP:0100825)2.87984442
39Pulmonary embolism (HP:0002204)2.77710822
40Gastrointestinal inflammation (HP:0004386)2.75325724
41Amyloidosis (HP:0011034)2.74915212
42Microcytic anemia (HP:0001935)2.72607081
43Periodontitis (HP:0000704)2.71925351
44Abnormality of T cell number (HP:0011839)2.70985121
45Leukocytosis (HP:0001974)2.70784380
46T lymphocytopenia (HP:0005403)2.70497664
47Increased IgM level (HP:0003496)2.66912430
48Recurrent pneumonia (HP:0006532)2.64749977
49Vasculitis (HP:0002633)2.64588646
50Panhypogammaglobulinemia (HP:0003139)2.55395135
51Dysostosis multiplex (HP:0000943)2.50925650
52Reticulocytopenia (HP:0001896)2.48205347
53Abnormality of the pleura (HP:0002103)2.45707733
54Chronic otitis media (HP:0000389)2.45324879
55Encephalitis (HP:0002383)2.43493587
56Gangrene (HP:0100758)2.41202668
57Agnosia (HP:0010524)2.35470965
58Colitis (HP:0002583)2.34415467
59Gingival bleeding (HP:0000225)2.34178968
60Hepatosplenomegaly (HP:0001433)2.33048967
61Recurrent lower respiratory tract infections (HP:0002783)2.32998303
62Increased IgE level (HP:0003212)2.31032597
63Eosinophilia (HP:0001880)2.26993835
64Epistaxis (HP:0000421)2.26612905
65Glomerulonephritis (HP:0000099)2.25501255
66Hemoptysis (HP:0002105)2.24860159
67Hypergammaglobulinemia (HP:0010702)2.24020332
68Keratitis (HP:0000491)2.23531998
69Abnormality of the heme biosynthetic pathway (HP:0010472)2.23078824
70Granulocytopenia (HP:0001913)2.21573142
71Interstitial pulmonary disease (HP:0006530)2.20757330
72Abnormality of the endocardium (HP:0004306)2.20558198
73Increased cerebral lipofuscin (HP:0011813)2.19829216
74Vertigo (HP:0002321)2.18825580
75Abnormality of the peritoneum (HP:0002585)2.17948275
76Abnormality of liposaccharide metabolism (HP:0010968)2.16906021
77Abnormality of glycosphingolipid metabolism (HP:0004343)2.16906021
78Abnormality of glycolipid metabolism (HP:0010969)2.16906021
79Skin ulcer (HP:0200042)2.16614787
80Abnormality of T cell physiology (HP:0011840)2.14293880
81Osteomyelitis (HP:0002754)2.12614652
82Abnormal platelet volume (HP:0011876)2.11608073
83Purpura (HP:0000979)2.11224600
84Abnormality of iron homeostasis (HP:0011031)2.09244371
85Prostate neoplasm (HP:0100787)2.09143161
86Acne (HP:0001061)2.08116901
87Myelodysplasia (HP:0002863)2.07998366
88Keratoconjunctivitis sicca (HP:0001097)2.06509339
89Glomerulopathy (HP:0100820)2.06310724
90Increased serum ferritin (HP:0003281)2.05554391
91Chromosomal breakage induced by crosslinking agents (HP:0003221)2.05350473
92Abnormality of the pericardium (HP:0001697)2.04402220
93Gastrointestinal infarctions (HP:0005244)2.03725728
94Increased neuronal autofluorescent lipopigment (HP:0002074)2.03570071
95Abnormal platelet function (HP:0011869)2.01667747
96Impaired platelet aggregation (HP:0003540)2.01667747
97Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01412427
98Chromsome breakage (HP:0040012)1.99471856
99Abnormality of T cells (HP:0002843)1.97715835
100Premature loss of primary teeth (HP:0006323)1.97711254
101Nasal polyposis (HP:0100582)1.97080737
102Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96751348
103Abnormality of the nasal mucosa (HP:0000433)1.96748123
104Thickened calvaria (HP:0002684)1.96693650
105Stomach cancer (HP:0012126)1.96254476
106Acute hepatic failure (HP:0006554)1.95096211
107Toxemia of pregnancy (HP:0100603)1.94853192
108Chest pain (HP:0100749)1.94667932
109Abnormality of eosinophils (HP:0001879)1.93709819
110Polyneuropathy (HP:0001271)1.92561449
111Sepsis (HP:0100806)1.92426322
112Bone marrow hypocellularity (HP:0005528)1.92112934
113Thyroiditis (HP:0100646)1.91351252
114Lymphopenia (HP:0001888)1.90019320
115Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89010725
116Abnormality of cells of the lymphoid lineage (HP:0012140)1.88243915
117Agammaglobulinemia (HP:0004432)1.85872331
118Loss of speech (HP:0002371)1.85338969
119Pulmonary infiltrates (HP:0002113)1.85338963
120Keratoconjunctivitis (HP:0001096)1.84294906
121Skin rash (HP:0000988)1.83487166
122Hematochezia (HP:0002573)1.83125020
123Abnormality of transition element cation homeostasis (HP:0011030)1.82509346
124Menorrhagia (HP:0000132)1.81784996
125Leukopenia (HP:0001882)1.81720749
126Arterial thrombosis (HP:0004420)1.79496360
127Abnormality of the prostate (HP:0008775)1.77440131
128Lymphoma (HP:0002665)1.77216732
129Mucopolysacchariduria (HP:0008155)1.76188687
130Urinary glycosaminoglycan excretion (HP:0003541)1.76188687
131Recurrent sinusitis (HP:0011108)1.75270569
132Basal ganglia calcification (HP:0002135)1.74633664
133Abnormality of polysaccharide metabolism (HP:0011012)1.73169773
134Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73169773
135Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73169773
136Slow saccadic eye movements (HP:0000514)1.72663030

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.70722078
2IRAK44.64778460
3MAP4K13.59748199
4IRAK33.23676220
5RIPK42.72601132
6FES2.27080369
7CSK2.24141334
8STK102.22627407
9BTK2.18019912
10FGR2.14908235
11MAP2K32.13518460
12EPHB12.10766080
13TEC2.00481984
14ZAP701.91294739
15CLK11.86681749
16TYK21.85076365
17GRK61.83257872
18TLK11.80688595
19TXK1.77794192
20TESK21.71279468
21PIM21.67814239
22HCK1.67757956
23KIT1.61941787
24NEK21.60463804
25PRPF4B1.52879492
26SIK31.48520159
27ERN11.46063776
28CSF1R1.43015855
29BUB11.38381295
30TBK11.36766915
31PIM11.36737155
32MAP3K111.28930081
33MAP3K11.20613877
34MAP3K141.19648517
35TGFBR21.16444412
36IKBKB1.15996545
37SYK1.12703714
38TAOK31.12237166
39KSR21.11272928
40WEE11.10078818
41LYN1.05717512
42LCK1.05097328
43PLK41.03686647
44PRKD21.03429659
45PAK41.01829441
46ITK1.01025781
47MARK21.00131450
48NME20.96408595
49KDR0.95216377
50MARK30.93691966
51ALK0.93519548
52CDK190.93234183
53LRRK20.92406763
54EIF2AK10.90761060
55IRAK20.89514497
56CDK120.88895545
57EPHA20.88324136
58PDK10.88011914
59JAK30.86202468
60BMPR20.81883978
61DAPK20.80732049
62PTK2B0.79125360
63STK160.78215009
64MAP3K120.78016681
65MAP3K70.76761460
66SIK20.76466193
67MAP3K30.75969434
68PRKG20.75677481
69STK110.75163410
70MAP2K40.74735940
71PTK60.72579957
72CAMK1D0.72301935
73RPS6KA40.71561515
74PDPK10.71107442
75MAP3K130.70838686
76IKBKE0.69062479
77FYN0.66752609
78CDK70.66662787
79PRKCQ0.66445456
80GRK70.65697707
81TRPM70.65527251
82TTN0.64993614
83JAK10.63940678
84NEK90.62597654
85MATK0.61999029
86MAP3K80.61040962
87MAPK120.60840060
88STK40.60775155
89MAPKAPK20.58653780
90TSSK60.57535251
91JAK20.57450931
92EPHA30.57204654
93MAP3K20.56625232
94PIK3CG0.55972664
95MAPK70.55496804
96EIF2AK20.55276559
97TAOK10.54943466
98YES10.52996068
99DYRK1B0.52834744
100RPS6KC10.52137761
101RPS6KL10.52137761
102HIPK20.52097570
103RPS6KA60.50950467
104ZAK0.50180972
105NUAK10.47833839
106STK380.47075692
107SGK30.46647602
108PLK10.42638170
109TNK20.41792253
110NLK0.41590036
111MAP3K50.40412298
112PRKCZ0.39938159
113CDK40.39422390
114CAMK1G0.39367765
115CDC42BPA0.39271696
116CAMKK10.39009071
117CAMKK20.38792872
118KSR10.38014097
119PRKCD0.37999541
120TAOK20.37888241
121FRK0.36387116
122IRAK10.35962899
123ARAF0.35759142
124STK240.34913682
125FGFR30.34878025
126SGK20.34787029
127GRK10.34563163
128RET0.34064391
129ABL10.34041618
130PTK20.33182432
131TRIB30.32316697
132TTK0.31571420
133MAPK40.31561078
134SMG10.31474751
135RAF10.31349486
136MST1R0.30673343
137MAPK110.29808304
138MAP3K60.29654503
139VRK10.29631194
140MAP2K60.29112469
141PRKCH0.27975790

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.28260747
2Leishmaniasis_Homo sapiens_hsa051403.14411770
3Asthma_Homo sapiens_hsa053102.79540694
4Other glycan degradation_Homo sapiens_hsa005112.24157253
5Osteoclast differentiation_Homo sapiens_hsa043802.20064443
6Hematopoietic cell lineage_Homo sapiens_hsa046402.13351345
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.98476897
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.93208356
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.93028095
10Pertussis_Homo sapiens_hsa051331.85157239
11Leukocyte transendothelial migration_Homo sapiens_hsa046701.83466320
12Type I diabetes mellitus_Homo sapiens_hsa049401.83002611
13B cell receptor signaling pathway_Homo sapiens_hsa046621.75487976
14Tuberculosis_Homo sapiens_hsa051521.74556818
15Primary immunodeficiency_Homo sapiens_hsa053401.71244698
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67155523
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66404437
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.64862188
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64623731
20DNA replication_Homo sapiens_hsa030301.63897027
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61698914
22Legionellosis_Homo sapiens_hsa051341.60902251
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58813595
24Measles_Homo sapiens_hsa051621.54080096
25Shigellosis_Homo sapiens_hsa051311.53013808
26Ribosome_Homo sapiens_hsa030101.52064872
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48604507
28Chemokine signaling pathway_Homo sapiens_hsa040621.47501352
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44321100
30Homologous recombination_Homo sapiens_hsa034401.42060539
31Malaria_Homo sapiens_hsa051441.36701581
32Herpes simplex infection_Homo sapiens_hsa051681.36071615
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.33930652
34Acute myeloid leukemia_Homo sapiens_hsa052211.30901941
35Salmonella infection_Homo sapiens_hsa051321.27236032
36Mismatch repair_Homo sapiens_hsa034301.26210058
37Antigen processing and presentation_Homo sapiens_hsa046121.24265687
38Toxoplasmosis_Homo sapiens_hsa051451.23202713
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23047475
40Base excision repair_Homo sapiens_hsa034101.22688655
41Lysosome_Homo sapiens_hsa041421.19433972
42Influenza A_Homo sapiens_hsa051641.17708048
43Epstein-Barr virus infection_Homo sapiens_hsa051691.13216761
44Graft-versus-host disease_Homo sapiens_hsa053321.12000315
45Apoptosis_Homo sapiens_hsa042101.08168126
46RNA polymerase_Homo sapiens_hsa030201.07373037
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07079583
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06643107
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05661216
50Hepatitis B_Homo sapiens_hsa051611.04204115
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02949022
52Non-small cell lung cancer_Homo sapiens_hsa052231.02029659
53TNF signaling pathway_Homo sapiens_hsa046680.98965532
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98665615
55Pentose phosphate pathway_Homo sapiens_hsa000300.98023139
56Allograft rejection_Homo sapiens_hsa053300.97598709
57Fanconi anemia pathway_Homo sapiens_hsa034600.96270956
58p53 signaling pathway_Homo sapiens_hsa041150.94793646
59Phagosome_Homo sapiens_hsa041450.93024285
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91380647
61T cell receptor signaling pathway_Homo sapiens_hsa046600.91023506
62Viral myocarditis_Homo sapiens_hsa054160.90268092
63Spliceosome_Homo sapiens_hsa030400.88371668
64Platelet activation_Homo sapiens_hsa046110.87237887
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86217147
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85350724
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81225153
68Arachidonic acid metabolism_Homo sapiens_hsa005900.79079352
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78001544
70Proteasome_Homo sapiens_hsa030500.76911934
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75267203
72Prolactin signaling pathway_Homo sapiens_hsa049170.74978884
73Cell cycle_Homo sapiens_hsa041100.73005960
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72715554
75Pyrimidine metabolism_Homo sapiens_hsa002400.72327880
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71501166
77Pancreatic cancer_Homo sapiens_hsa052120.71271085
78Rheumatoid arthritis_Homo sapiens_hsa053230.71251772
79Caffeine metabolism_Homo sapiens_hsa002320.69608203
80Hepatitis C_Homo sapiens_hsa051600.68966409
81Dorso-ventral axis formation_Homo sapiens_hsa043200.68436864
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67354219
83Renal cell carcinoma_Homo sapiens_hsa052110.67254930
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66846948
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.65787436
86Chronic myeloid leukemia_Homo sapiens_hsa052200.65642175
87FoxO signaling pathway_Homo sapiens_hsa040680.64461164
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62830585
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.61806535
90RNA transport_Homo sapiens_hsa030130.60824375
91Non-homologous end-joining_Homo sapiens_hsa034500.60001917
92VEGF signaling pathway_Homo sapiens_hsa043700.58868090
93Viral carcinogenesis_Homo sapiens_hsa052030.58690232
94Choline metabolism in cancer_Homo sapiens_hsa052310.58665474
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.58452240
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.57977503
97Autoimmune thyroid disease_Homo sapiens_hsa053200.56899698
98Nucleotide excision repair_Homo sapiens_hsa034200.56094709
99Notch signaling pathway_Homo sapiens_hsa043300.55652521
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.55371566
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55141487
102HTLV-I infection_Homo sapiens_hsa051660.54512973
103Type II diabetes mellitus_Homo sapiens_hsa049300.53979367
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53818956
105GnRH signaling pathway_Homo sapiens_hsa049120.53509939
106Endocytosis_Homo sapiens_hsa041440.52994563
107Renin-angiotensin system_Homo sapiens_hsa046140.52388199
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50610120
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50286832
110Collecting duct acid secretion_Homo sapiens_hsa049660.50179968
111Regulation of autophagy_Homo sapiens_hsa041400.47148386
112Inositol phosphate metabolism_Homo sapiens_hsa005620.46401980
113Rap1 signaling pathway_Homo sapiens_hsa040150.45129392
114* MAPK signaling pathway_Homo sapiens_hsa040100.45127715
115Insulin resistance_Homo sapiens_hsa049310.44818219
116Amoebiasis_Homo sapiens_hsa051460.44532822
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44484438
118African trypanosomiasis_Homo sapiens_hsa051430.43046571
119Endometrial cancer_Homo sapiens_hsa052130.42296440
120HIF-1 signaling pathway_Homo sapiens_hsa040660.41875250
121Sphingolipid metabolism_Homo sapiens_hsa006000.41441166
122Bladder cancer_Homo sapiens_hsa052190.40670390
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39895661
124mTOR signaling pathway_Homo sapiens_hsa041500.38127683
125One carbon pool by folate_Homo sapiens_hsa006700.37687502
126MicroRNAs in cancer_Homo sapiens_hsa052060.36562420
127Colorectal cancer_Homo sapiens_hsa052100.35045428
128Small cell lung cancer_Homo sapiens_hsa052220.34784783

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