RASIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)7.61105581
2endothelium development (GO:0003158)6.96362789
3vascular endothelial growth factor signaling pathway (GO:0038084)6.33526767
4positive regulation of vasculogenesis (GO:2001214)6.31707389
5lymphangiogenesis (GO:0001946)6.16790852
6blood vessel maturation (GO:0001955)5.98691443
7cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.82264367
8surfactant homeostasis (GO:0043129)5.81874409
9regulation of vasculogenesis (GO:2001212)5.59046650
10endothelial tube morphogenesis (GO:0061154)5.45428423
11morphogenesis of an endothelium (GO:0003159)5.45428423
12retina vasculature morphogenesis in camera-type eye (GO:0061299)5.44786460
13regulation of endothelial cell differentiation (GO:0045601)5.30179665
14angiogenesis involved in wound healing (GO:0060055)5.18507992
15heart trabecula formation (GO:0060347)5.12836207
16endothelial cell differentiation (GO:0045446)4.97253798
17chemical homeostasis within a tissue (GO:0048875)4.81238047
18basement membrane organization (GO:0071711)4.72443931
19endothelial cell morphogenesis (GO:0001886)4.64726252
20positive regulation of odontogenesis (GO:0042482)4.60620672
21glomerular filtration (GO:0003094)4.53284944
22ovulation from ovarian follicle (GO:0001542)4.49914179
23renal filtration (GO:0097205)4.42723150
24patterning of blood vessels (GO:0001569)4.42324418
25cardiac myofibril assembly (GO:0055003)4.36057318
26vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.31960354
27bundle of His cell to Purkinje myocyte communication (GO:0086069)4.17203966
28plasma membrane repair (GO:0001778)4.11067976
29cell migration involved in sprouting angiogenesis (GO:0002042)4.06596299
30sarcomere organization (GO:0045214)3.98561990
31wound healing, spreading of epidermal cells (GO:0035313)3.96566286
32venous blood vessel morphogenesis (GO:0048845)3.93111427
33embryonic heart tube development (GO:0035050)3.86757842
34blood vessel endothelial cell migration (GO:0043534)3.86573521
35negative regulation of blood vessel endothelial cell migration (GO:0043537)3.76534279
36positive regulation of urine volume (GO:0035810)3.73448256
37negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.70371021
38hyaluronan catabolic process (GO:0030214)3.70043657
39regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.68005045
40sprouting angiogenesis (GO:0002040)3.65555144
41myofibril assembly (GO:0030239)3.64665388
42ventricular trabecula myocardium morphogenesis (GO:0003222)3.62719473
43* vasculogenesis (GO:0001570)3.62547346
44positive regulation of endothelial cell differentiation (GO:0045603)3.58865778
45peptidyl-tyrosine autophosphorylation (GO:0038083)3.55217991
46ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.50763875
47atrioventricular valve morphogenesis (GO:0003181)3.49039202
48negative regulation of endothelial cell migration (GO:0010596)3.46781680
49heart trabecula morphogenesis (GO:0061384)3.45931842
50negative regulation of focal adhesion assembly (GO:0051895)3.45747936
51negative regulation of cell junction assembly (GO:1901889)3.45747936
52negative regulation of adherens junction organization (GO:1903392)3.45747936
53negative regulation of Rho protein signal transduction (GO:0035024)3.41138929
54regulation of vascular permeability (GO:0043114)3.38819347
55regulation of cardioblast differentiation (GO:0051890)3.36740046
56regulation of sarcomere organization (GO:0060297)3.36520468
57trabecula morphogenesis (GO:0061383)3.30321974
58negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.26933645
59regulation of synapse maturation (GO:0090128)3.26575891
60cardiac muscle tissue morphogenesis (GO:0055008)3.21492931
61mRNA transcription from RNA polymerase II promoter (GO:0042789)3.21420004
62trabecula formation (GO:0060343)3.20729044
63negative regulation of endothelial cell apoptotic process (GO:2000352)3.17573921
64cAMP biosynthetic process (GO:0006171)3.16259361
65regulation of actin filament-based movement (GO:1903115)3.16026502
66blood vessel remodeling (GO:0001974)3.05089655
67negative regulation of angiogenesis (GO:0016525)3.04375954
68endothelial cell migration (GO:0043542)3.04271864
69regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.02890847
70negative regulation of vascular permeability (GO:0043116)3.01069387
71negative regulation of potassium ion transmembrane transport (GO:1901380)3.00561937
72positive regulation of endothelial cell migration (GO:0010595)3.00352083
73* angiogenesis (GO:0001525)2.99247634
74coronary vasculature morphogenesis (GO:0060977)2.99222672
75positive regulation of receptor recycling (GO:0001921)2.98050513
76positive regulation of protein kinase C signaling (GO:0090037)2.97665476
77cardiac muscle cell development (GO:0055013)2.95682252
78embryonic foregut morphogenesis (GO:0048617)2.95425802
79positive regulation of vascular permeability (GO:0043117)2.95059965
80glomerular basement membrane development (GO:0032836)2.92272127
81muscle tissue morphogenesis (GO:0060415)2.91727767
82actomyosin structure organization (GO:0031032)2.91704807
83regulation of p38MAPK cascade (GO:1900744)2.90997002
84negative regulation of blood vessel morphogenesis (GO:2000181)2.90509030
85cell-substrate junction assembly (GO:0007044)2.90383986
86cytoskeletal anchoring at plasma membrane (GO:0007016)2.90371380
87nephron epithelium development (GO:0072009)2.89965208
88dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.89036225
89actin-myosin filament sliding (GO:0033275)2.88585175
90muscle filament sliding (GO:0030049)2.88585175
91cardiac cell development (GO:0055006)2.87933359
92branching involved in salivary gland morphogenesis (GO:0060445)2.87929956
93transcytosis (GO:0045056)2.87301404
94negative regulation of epithelial cell migration (GO:0010633)2.87236095
95artery development (GO:0060840)2.87081343
96negative regulation of DNA biosynthetic process (GO:2000279)2.86181293
97cardiac muscle cell proliferation (GO:0060038)2.85965122
98endothelial cell proliferation (GO:0001935)2.84588231
99tricarboxylic acid cycle (GO:0006099)2.84246348
100Notch receptor processing (GO:0007220)2.81257529
101regulation of endothelial cell migration (GO:0010594)2.77408705
102negative regulation of nitric-oxide synthase activity (GO:0051001)2.77186454
103regulation of the force of heart contraction (GO:0002026)2.76972040
104adherens junction assembly (GO:0034333)2.76640734
105heart valve formation (GO:0003188)2.76433199
106negative regulation of platelet activation (GO:0010544)2.76237532
107regulation of urine volume (GO:0035809)2.75317215
108establishment of endothelial barrier (GO:0061028)2.75156729
109cardiac muscle contraction (GO:0060048)2.73377609
110fatty acid transmembrane transport (GO:1902001)2.73089245
111ventricular cardiac muscle cell action potential (GO:0086005)2.72902460
112regulation of blood vessel endothelial cell migration (GO:0043535)2.72874483
113negative regulation of vasculature development (GO:1901343)2.72432239
114positive regulation of blood vessel endothelial cell migration (GO:0043536)2.72287093
115cell-substrate adherens junction assembly (GO:0007045)2.72221155
116focal adhesion assembly (GO:0048041)2.72221155
117Notch signaling involved in heart development (GO:0061314)2.71730651
118cell migration involved in heart development (GO:0060973)2.69795614
119cyclic purine nucleotide metabolic process (GO:0052652)2.69659984
120peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.69468936
121negative regulation of endothelial cell proliferation (GO:0001937)2.69159525
122regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.68315033
123cGMP-mediated signaling (GO:0019934)2.67658459
124neuron projection extension involved in neuron projection guidance (GO:1902284)2.65310147
125axon extension involved in axon guidance (GO:0048846)2.65310147
126cellular response to nitric oxide (GO:0071732)2.64388046
127endothelial cell chemotaxis (GO:0035767)2.63378437
128cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.62708184
129mRNA transcription (GO:0009299)2.62699587
130labyrinthine layer development (GO:0060711)2.59832508
131negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.58038933
132regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.57776306
133positive regulation of endothelial cell proliferation (GO:0001938)2.56953583
134semaphorin-plexin signaling pathway (GO:0071526)2.56847008
135regulation of cardiac muscle cell contraction (GO:0086004)2.56621775
136regulation of epithelial cell migration (GO:0010632)2.55019908
137cell communication involved in cardiac conduction (GO:0086065)2.55019146
138protein kinase C signaling (GO:0070528)2.54246261
139wound healing, spreading of cells (GO:0044319)2.52283151
140regulation of endothelial cell proliferation (GO:0001936)2.51677480
141apoptotic process involved in morphogenesis (GO:0060561)2.50503574
142negative regulation of chondrocyte differentiation (GO:0032331)2.50147974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.04614105
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.61162248
3CLOCK_20551151_ChIP-Seq_293T_Human3.29412947
4GATA2_21666600_ChIP-Seq_HMVEC_Human3.17320631
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.99396010
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.88447693
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.87175145
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.77375082
9ZNF263_19887448_ChIP-Seq_K562_Human2.48714379
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.38061276
11EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.32401303
12TBX20_22328084_ChIP-Seq_HEART_Mouse2.31477628
13TBX20_22080862_ChIP-Seq_HEART_Mouse2.31477628
14* ELK3_25401928_ChIP-Seq_HUVEC_Human2.25584798
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05207350
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01759125
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.96374453
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93833148
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92495991
20KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87575429
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86674158
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86224740
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.86148084
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.81606430
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.81034683
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.80270066
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.78555002
28* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76702391
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.67435318
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65492808
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.62953467
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61884025
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59896286
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59896286
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59407351
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58487567
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.53927645
38P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52931867
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.52804792
40SMC4_20622854_ChIP-Seq_HELA_Human1.51737240
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.49106098
42* KDM2B_26808549_Chip-Seq_K562_Human1.46323364
43P68_20966046_ChIP-Seq_HELA_Human1.46010738
44KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45412843
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45029450
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44196686
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43082694
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38318905
49GATA1_19941826_ChIP-Seq_K562_Human1.36870730
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34807409
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34227660
52TCF7_22412390_ChIP-Seq_EML_Mouse1.32846009
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31139125
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30749023
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30481651
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30250583
57SMC3_22415368_ChIP-Seq_MEFs_Mouse1.29922678
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29887834
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28669653
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28224130
61NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28190100
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26710702
63DROSHA_22980978_ChIP-Seq_HELA_Human1.26652275
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25420971
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25038460
66LXR_22158963_ChIP-Seq_LIVER_Mouse1.24584992
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24538384
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.24427039
69CJUN_26792858_Chip-Seq_BT549_Human1.23312829
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22851900
71AHR_22903824_ChIP-Seq_MCF-7_Human1.22734479
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21855989
73TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21516011
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20882112
75ISL1_27105846_Chip-Seq_CPCs_Mouse1.20851418
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.20368443
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.20248009
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20241013
79* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19953630
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19784800
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19197334
82* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.17769410
83TCF4_18268006_ChIP-ChIP_LS174T_Human1.17550877
84RACK7_27058665_Chip-Seq_MCF-7_Human1.17539977
85KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.15241350
86KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.15241350
87KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.15241350
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.13959204
89VDR_21846776_ChIP-Seq_THP-1_Human1.13851041
90LXR_22292898_ChIP-Seq_THP-1_Human1.13556894
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13348583
92MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.13295312
93SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13278992
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.13009864
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12440387
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12380855
97KDM2B_26808549_Chip-Seq_JURKAT_Human1.12123613
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11317574
99GATA1_22025678_ChIP-Seq_K562_Human1.11034506
100SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10938681
101TET1_21490601_ChIP-Seq_MESCs_Mouse1.10426555
102FOXO3_23340844_ChIP-Seq_DLD1_Human1.09406417
103* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09392430
104SOX2_20726797_ChIP-Seq_SW620_Human1.08767664
105NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08222730
106KDM2B_26808549_Chip-Seq_DND41_Human1.07036392
107* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06649401
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06032236
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05354794
110SA1_27219007_Chip-Seq_ERYTHROID_Human1.03761641
111TP53_23651856_ChIP-Seq_MEFs_Mouse1.03463309
112* CREB1_26743006_Chip-Seq_LNCaP_Human1.02515564
113STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02120739
114* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01617293
115MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01611729
116JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00509156
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99855184
118ATF3_27146783_Chip-Seq_COLON_Human0.99852723
119TP53_22127205_ChIP-Seq_IMR90_Human0.97866169
120DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97268943
121TP53_20018659_ChIP-ChIP_R1E_Mouse0.96946869
122* NCOR1_26117541_ChIP-Seq_K562_Human0.96834574
123* RING1B_27294783_Chip-Seq_ESCs_Mouse0.96783051
124CTCF_27219007_Chip-Seq_Bcells_Human0.96294138
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94184136
126* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93597986
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93187153
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93164428
129NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93142314
130EGR1_19374776_ChIP-ChIP_THP-1_Human0.92362893
131MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.91869854
132* RNF2_27304074_Chip-Seq_ESCs_Mouse0.91759358
133SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91284666
134SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91255712
135OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91085720
136CDX2_20551321_ChIP-Seq_CACO-2_Human0.90818074
137SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90271766
138SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90271766
139RXR_22158963_ChIP-Seq_LIVER_Mouse0.89923828
140POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89816424
141ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89274501
142* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88747082
143JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88636079
144RUNX1_27514584_Chip-Seq_MCF-7_Human0.87486847
145ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87305498
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87031868
147SMAD4_21741376_ChIP-Seq_HESCs_Human0.86913343
148SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86594020
149FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85669928

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system7.54879338
2MP0001879_abnormal_lymphatic_vessel5.83483619
3MP0005167_abnormal_blood-brain_barrier5.04602412
4MP0004272_abnormal_basement_membrane4.67733430
5MP0004084_abnormal_cardiac_muscle4.20761977
6MP0003828_pulmonary_edema3.07980083
7MP0004215_abnormal_myocardial_fiber3.00696166
8MP0002837_dystrophic_cardiac_calcinosis2.94735247
9MP0000751_myopathy2.94472588
10MP0004036_abnormal_muscle_relaxation2.80582708
11MP0006138_congestive_heart_failure2.58756636
12MP0010030_abnormal_orbit_morphology2.49123320
13MP0005330_cardiomyopathy2.28273590
14MP0002877_abnormal_melanocyte_morpholog2.27989621
15MP0005385_cardiovascular_system_phenoty2.12018350
16MP0001544_abnormal_cardiovascular_syste2.12018350
17MP0002972_abnormal_cardiac_muscle2.05715320
18MP0003724_increased_susceptibility_to2.02545967
19MP0004233_abnormal_muscle_weight1.95734293
20MP0008775_abnormal_heart_ventricle1.90755807
21MP0000767_abnormal_smooth_muscle1.88603647
22MP0004085_abnormal_heartbeat1.88524803
23MP0010630_abnormal_cardiac_muscle1.85282847
24MP0003279_aneurysm1.83727676
25MP0002127_abnormal_cardiovascular_syste1.78280876
26MP0002332_abnormal_exercise_endurance1.78072935
27MP0004484_altered_response_of1.77371764
28MP0003705_abnormal_hypodermis_morpholog1.76385420
29MP0003122_maternal_imprinting1.75144334
30MP0005620_abnormal_muscle_contractility1.72488153
31MP0006054_spinal_hemorrhage1.69558311
32MP0000750_abnormal_muscle_regeneration1.68783729
33MP0000749_muscle_degeneration1.66425849
34MP0004087_abnormal_muscle_fiber1.63814133
35MP0000013_abnormal_adipose_tissue1.61709745
36MP0001849_ear_inflammation1.57656662
37MP0002138_abnormal_hepatobiliary_system1.56300388
38MP0005623_abnormal_meninges_morphology1.54072829
39MP0003566_abnormal_cell_adhesion1.51918490
40MP0001661_extended_life_span1.48274167
41MP0003646_muscle_fatigue1.47860778
42MP0000343_altered_response_to1.47612258
43MP0001958_emphysema1.42721036
44MP0005165_increased_susceptibility_to1.41930157
45MP0005595_abnormal_vascular_smooth1.41339830
46MP0002128_abnormal_blood_circulation1.38874659
47MP0004130_abnormal_muscle_cell1.37571199
48MP0002925_abnormal_cardiovascular_devel1.35296502
49MP0004510_myositis1.33682103
50MP0000249_abnormal_blood_vessel1.29861634
51MP0002295_abnormal_pulmonary_circulatio1.25777610
52MP0002106_abnormal_muscle_physiology1.24217423
53MP0003137_abnormal_impulse_conducting1.22495326
54MP0000266_abnormal_heart_morphology1.18886317
55MP0004145_abnormal_muscle_electrophysio1.17503262
56MP0005670_abnormal_white_adipose1.16631890
57MP0002933_joint_inflammation1.16203303
58MP0001614_abnormal_blood_vessel1.15301662
59MP0002796_impaired_skin_barrier1.14012175
60MP0003567_abnormal_fetal_cardiomyocyte1.07489807
61MP0004782_abnormal_surfactant_physiolog1.07200248
62MP0005084_abnormal_gallbladder_morpholo1.03630364
63MP0005083_abnormal_biliary_tract1.02063834
64MP0005187_abnormal_penis_morphology1.01349418
65MP0005369_muscle_phenotype1.00319201
66MP0000230_abnormal_systemic_arterial0.98662780
67MP0004883_abnormal_blood_vessel0.98310433
68MP0005503_abnormal_tendon_morphology0.94863971
69MP0004147_increased_porphyrin_level0.94795686
70MP0010234_abnormal_vibrissa_follicle0.90971996
71MP0000759_abnormal_skeletal_muscle0.89690565
72MP0003303_peritoneal_inflammation0.89607612
73MP0004858_abnormal_nervous_system0.86622124
74MP0001784_abnormal_fluid_regulation0.85862601
75MP0005666_abnormal_adipose_tissue0.85794679
76MP0000537_abnormal_urethra_morphology0.81725830
77MP0005501_abnormal_skin_physiology0.81367726
78MP0008438_abnormal_cutaneous_collagen0.80102584
79MP0003300_gastrointestinal_ulcer0.79963407
80MP0003221_abnormal_cardiomyocyte_apopto0.79885789
81MP0002133_abnormal_respiratory_system0.79766074
82MP0005388_respiratory_system_phenotype0.79766074
83MP0005375_adipose_tissue_phenotype0.78067341
84MP0009278_abnormal_bone_marrow0.76009958
85MP0000003_abnormal_adipose_tissue0.75785986
86MP0005023_abnormal_wound_healing0.74555288
87MP0005257_abnormal_intraocular_pressure0.73839619
88MP0005058_abnormal_lysosome_morphology0.73335163
89MP0002060_abnormal_skin_morphology0.73283943
90MP0005164_abnormal_response_to0.71348900
91MP0003091_abnormal_cell_migration0.70505411
92MP0003950_abnormal_plasma_membrane0.70470369
93MP0005275_abnormal_skin_tensile0.69611200
94MP0003948_abnormal_gas_homeostasis0.69413426
95MP0001915_intracranial_hemorrhage0.69294979
96MP0005171_absent_coat_pigmentation0.67730043
97MP0000049_abnormal_middle_ear0.67713193
98MP0000467_abnormal_esophagus_morphology0.67403380
99MP0009379_abnormal_foot_pigmentation0.67227454
100MP0003453_abnormal_keratinocyte_physiol0.66745831
101MP0004808_abnormal_hematopoietic_stem0.66691819
102MP0004185_abnormal_adipocyte_glucose0.65852778
103MP0002108_abnormal_muscle_morphology0.64400155
104MP0001851_eye_inflammation0.62994401
105MP0005380_embryogenesis_phenotype0.62291766
106MP0001672_abnormal_embryogenesis/_devel0.62291766
107MP0002269_muscular_atrophy0.62214923
108MP0003385_abnormal_body_wall0.62178769
109MP0003191_abnormal_cellular_cholesterol0.60447223
110MP0002697_abnormal_eye_size0.60213208
111MP0003984_embryonic_growth_retardation0.59716991
112MP0002088_abnormal_embryonic_growth/wei0.59703004
113MP0005409_darkened_coat_color0.59013079
114MP0002896_abnormal_bone_mineralization0.58162866
115MP0009780_abnormal_chondrocyte_physiolo0.57740604
116MP0000678_abnormal_parathyroid_gland0.55277037
117MP0003941_abnormal_skin_development0.55127519
118MP0000762_abnormal_tongue_morphology0.54900563
119MP0002086_abnormal_extraembryonic_tissu0.53397005
120MP0000465_gastrointestinal_hemorrhage0.52536417
121MP0003119_abnormal_digestive_system0.50628320
122MP0000733_abnormal_muscle_development0.48255901
123MP0003638_abnormal_response/metabolism_0.47822051
124MP0000747_muscle_weakness0.47013411
125MP0003943_abnormal_hepatobiliary_system0.44987609
126MP0001175_abnormal_lung_morphology0.44107839
127MP0002971_abnormal_brown_adipose0.44069184

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)5.75494462
2Sudden death (HP:0001699)5.65799293
3Ventricular tachycardia (HP:0004756)5.04973058
4Muscle fiber splitting (HP:0003555)4.86496713
5Hematochezia (HP:0002573)4.59789293
6Spontaneous hematomas (HP:0007420)4.35313537
7Increased connective tissue (HP:0009025)4.20745086
8Atrial fibrillation (HP:0005110)4.19654595
9Cerebral hemorrhage (HP:0001342)4.08557236
10Supraventricular arrhythmia (HP:0005115)4.06129515
11Esophageal varix (HP:0002040)3.98886479
12Lymphangioma (HP:0100764)3.96098617
13Hyporeflexia of lower limbs (HP:0002600)3.94839435
14Primary atrial arrhythmia (HP:0001692)3.93097707
15Supraventricular tachycardia (HP:0004755)3.76742693
16Premature rupture of membranes (HP:0001788)3.70301186
17Right ventricular cardiomyopathy (HP:0011663)3.65599603
18Exercise-induced muscle cramps (HP:0003710)3.51075063
19Lipoatrophy (HP:0100578)3.49568440
20Difficulty running (HP:0009046)3.48022287
21Cerebral aneurysm (HP:0004944)3.46186290
22Calf muscle hypertrophy (HP:0008981)3.41657492
23Exercise-induced myalgia (HP:0003738)3.41043280
24Myotonia (HP:0002486)3.33174636
25Arterial tortuosity (HP:0005116)3.29860694
26Visceral angiomatosis (HP:0100761)3.22056403
27Increased variability in muscle fiber diameter (HP:0003557)3.17485012
28Vascular tortuosity (HP:0004948)3.16878564
29Cavernous hemangioma (HP:0001048)3.10905386
30Broad metatarsal (HP:0001783)3.10452449
31Syncope (HP:0001279)3.09304416
32Muscle hypertrophy of the lower extremities (HP:0008968)3.07448923
33Hemangiomatosis (HP:0007461)3.05438718
34Abnormality of the nasal mucosa (HP:0000433)3.04444379
35Abnormality of the calf musculature (HP:0001430)3.03388612
36Shallow orbits (HP:0000586)3.02602016
37Nonimmune hydrops fetalis (HP:0001790)3.00037318
38Prolonged QT interval (HP:0001657)2.99817367
39EMG: myopathic abnormalities (HP:0003458)2.98370638
40Conjunctival telangiectasia (HP:0000524)2.90537475
41Myoglobinuria (HP:0002913)2.90096646
42Subaortic stenosis (HP:0001682)2.90072861
43Abnormality of the left ventricular outflow tract (HP:0011103)2.90072861
44Dilated cardiomyopathy (HP:0001644)2.88062418
45Atrioventricular block (HP:0001678)2.86360928
46Abnormality of skeletal muscle fiber size (HP:0012084)2.84023542
47Difficulty climbing stairs (HP:0003551)2.83709266
48Palpitations (HP:0001962)2.79666641
49Distal lower limb amyotrophy (HP:0008944)2.79272607
50Skull defect (HP:0001362)2.65562169
51Spinal rigidity (HP:0003306)2.64346185
52Absent hand (HP:0004050)2.63102126
53Porencephaly (HP:0002132)2.60242048
54Neonatal death (HP:0003811)2.59866805
55Adactyly (HP:0009776)2.55328791
56Mesangial abnormality (HP:0001966)2.52786346
57Heart block (HP:0012722)2.51627396
58Pulmonary artery stenosis (HP:0004415)2.50998549
59Round ear (HP:0100830)2.50981704
60Wormian bones (HP:0002645)2.49836043
61Trismus (HP:0000211)2.47855618
62Protrusio acetabuli (HP:0003179)2.45313991
63Asymmetry of the thorax (HP:0001555)2.44289300
64Overgrowth (HP:0001548)2.40732724
65Abnormal atrioventricular conduction (HP:0005150)2.40222745
66Rectal prolapse (HP:0002035)2.35828126
67Ventricular fibrillation (HP:0001663)2.32747325
68Ventricular arrhythmia (HP:0004308)2.31852835
69Aneurysm (HP:0002617)2.28541927
70Asymmetric septal hypertrophy (HP:0001670)2.27593458
71Portal hypertension (HP:0001409)2.26957696
72Centrally nucleated skeletal muscle fibers (HP:0003687)2.26607370
73Rhabdomyolysis (HP:0003201)2.25321380
74Aortic dissection (HP:0002647)2.24443038
75Hydroureter (HP:0000072)2.23751188
76Broad face (HP:0000283)2.23711662
77Abnormality of the vasculature of the conjunctiva (HP:0008054)2.22195369
78Hemorrhage of the eye (HP:0011885)2.21392653
79Acanthosis nigricans (HP:0000956)2.21083239
80Hemiplegia (HP:0002301)2.18533738
81Deep venous thrombosis (HP:0002625)2.17002652
82Bundle branch block (HP:0011710)2.14878609
83Vertebral clefting (HP:0008428)2.12258883
84Muscle stiffness (HP:0003552)2.11797751
85Hypoglycemic coma (HP:0001325)2.11682902
86Abnormal vertebral ossification (HP:0100569)2.10363744
87Ectopia lentis (HP:0001083)2.09121610
88Mucosal telangiectasiae (HP:0100579)2.08329466
89Wrist flexion contracture (HP:0001239)2.07264185
90Mitral valve prolapse (HP:0001634)2.06224121
91Venous insufficiency (HP:0005293)2.05656549
92Rapidly progressive (HP:0003678)2.03858390
93Capillary hemangiomas (HP:0005306)2.01294397
94Lower limb amyotrophy (HP:0007210)2.01015027
95Reduced subcutaneous adipose tissue (HP:0003758)1.99068199
96Blue sclerae (HP:0000592)1.98653168
97Achilles tendon contracture (HP:0001771)1.98462134
98Stroke (HP:0001297)1.96822753
99Ketoacidosis (HP:0001993)1.96776859
100Abnormality of the calcaneus (HP:0008364)1.96574059
101Hypoplastic left heart (HP:0004383)1.95997593
102Abnormality of the hepatic vasculature (HP:0006707)1.95147336
103Venous abnormality (HP:0002624)1.94836517
104Abnormality of the intrinsic pathway (HP:0010989)1.94648830
105Disproportionate tall stature (HP:0001519)1.94596574
106Myocardial infarction (HP:0001658)1.94558398
107Vertebral compression fractures (HP:0002953)1.93635760
108Limb-girdle muscle atrophy (HP:0003797)1.93226197
109Abnormal EKG (HP:0003115)1.91901651
110Joint stiffness (HP:0001387)1.91413919
111Bulbar palsy (HP:0001283)1.90853574
112High pitched voice (HP:0001620)1.90739648
113Calcaneovalgus deformity (HP:0001848)1.90674058
114Distal arthrogryposis (HP:0005684)1.90215054
115Nuclear cataract (HP:0100018)1.88410603
116Areflexia of lower limbs (HP:0002522)1.88395888
117Conjunctival hamartoma (HP:0100780)1.88225604
118Hypoplasia of the iris (HP:0007676)1.88155438
119Intestinal polyp (HP:0005266)1.88149610
120Ankyloglossia (HP:0010296)1.87734734
121Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85448653
122Short 4th metacarpal (HP:0010044)1.85448653
123Ulnar bowing (HP:0003031)1.84295300
124Intestinal polyposis (HP:0200008)1.84165654
125Facial diplegia (HP:0001349)1.82938835
126Cervical subluxation (HP:0003308)1.82487029
127Dilatation of the ascending aorta (HP:0005111)1.81325952
128Pulmonary hypertension (HP:0002092)1.80991988
129Aortic aneurysm (HP:0004942)1.80569411
130Elbow flexion contracture (HP:0002987)1.79975345
131Abnormality of the 4th metacarpal (HP:0010012)1.79287614
132Impaired pain sensation (HP:0007328)1.78853004
133Abnormality of pain sensation (HP:0010832)1.78853004
134Short nail (HP:0001799)1.78699308
135Type 1 muscle fiber predominance (HP:0003803)1.77959379
136Thin ribs (HP:0000883)1.77762131
137Joint contractures involving the joints of the feet (HP:0100492)1.75094579
138Flexion contracture of toe (HP:0005830)1.75094579
139Mildly elevated creatine phosphokinase (HP:0008180)1.74191638
140Aortic valve stenosis (HP:0001650)1.73834168
141Tetraparesis (HP:0002273)1.73030086
142Mask-like facies (HP:0000298)1.72343322
143Short chin (HP:0000331)1.72220914
144Absent eyebrow (HP:0002223)1.71159635
145Distal lower limb muscle weakness (HP:0009053)1.70935184
146Soft skin (HP:0000977)1.69218284
147Nemaline bodies (HP:0003798)1.69016945
148Palmoplantar keratoderma (HP:0000982)1.67997095

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.31042330
2TGFBR23.31069699
3TGFBR12.77566682
4RIPK12.30893599
5LMTK22.25647222
6EPHB22.16286737
7PTK2B2.14772065
8EEF2K2.06572522
9TIE110.9694635
10MYLK1.95239300
11TTN1.94492099
12FES1.69394301
13TRIB31.60141709
14GRK11.59592886
15NTRK11.53868537
16PHKG21.48258827
17PHKG11.48258827
18FER1.46590509
19PKN21.45361357
20DMPK1.43181438
21ICK1.40735479
22ERN11.37216592
23MAP2K31.29619476
24INSRR1.21613900
25PTK61.20749789
26PRKG21.20613502
27PDK21.20475934
28MAP3K31.10604650
29MST1R1.04541397
30MAPK121.00142321
31EPHB10.97089117
32PRKD10.93352694
33PRKD30.89630386
34BCKDK0.88902072
35OBSCN0.85075681
36PDGFRA0.84428557
37TESK10.84230151
38SMG10.83678150
39PAK40.81051266
40ARAF0.81019765
41PDK40.79704832
42PDK30.79704832
43LATS20.77556190
44RPS6KA20.74912276
45PTK20.74659320
46LRRK20.70066986
47ILK0.64685763
48TRPM70.64320850
49EPHA20.63871994
50IRAK30.63061357
51MOS0.62996010
52GRK50.61968258
53FGFR40.60913306
54BCR0.57111528
55MAP3K130.53993926
56ROCK10.53168518
57AKT30.52669846
58MAP3K110.52350318
59WNK40.52293378
60STK240.51195087
61MAP3K70.50299161
62PRKCH0.49657429
63PRKAA20.49224234
64CAMK40.47681680
65MAP2K40.47624231
66RET0.47084496
67MAP3K10.46694001
68MAPKAPK50.46301314
69FGFR20.46261813
70MET0.45136848
71PAK20.44352065
72LATS10.43984393
73MARK20.43570627
74PRPF4B0.43477829
75NME20.43299840
76RPS6KB20.42503463
77PAK30.41976659
78BMX0.41062580
79CDK120.40580679
80MAPK70.40350015
81TYRO30.39505892
82BRAF0.39486664
83MAP3K60.38718472
84MAP2K10.38350928
85ABL20.36956238
86SIK10.36749553
87PIK3CA0.36418312
88MAPKAPK30.35503829
89PRKAA10.35150082
90GSK3A0.34682421
91FGFR30.34438219
92PRKCE0.34331113
93PRKD20.33250676
94PDPK10.31999631
95MAP3K100.31964680
96MAP2K20.31660275
97MAP3K80.31195830
98MARK30.31078165
99CSK0.30678770
100SRC0.29899153
101IGF1R0.28865339
102NLK0.28452752
103RPS6KL10.28289188
104RPS6KC10.28289188
105EGFR0.28058023
106ZAP700.27171549
107SIK20.26996933
108NME10.26944730
109FLT30.26223616
110SIK30.25694434
111ROCK20.25601814
112ADRBK10.25012775
113GRK70.23943378
114STK38L0.23397698
115KSR20.23012416
116MAPK150.22921142
117PDGFRB0.21696285
118ERBB40.20966265
119DAPK30.19779050
120PIM20.19605608
121PRKACB0.19150098
122MAPK100.18191006
123CDK80.17890552
124PAK10.17676850
125STK100.17624143
126TSSK60.17578721
127AKT20.17287673
128CAMK2A0.16063006
129CDK60.15866414
130EPHA30.15576759
131MAPK110.14808465
132CDC42BPA0.14774420
133CDK90.14307843
134RPS6KA60.14046236
135MTOR0.12250045
136MAPK40.12220924
137NEK10.12153223
138CAMK2D0.11113673
139INSR0.11099725
140CAMK10.11068836

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.66271066
2Dilated cardiomyopathy_Homo sapiens_hsa054142.89179822
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.88936636
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.54747467
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.47047568
6ECM-receptor interaction_Homo sapiens_hsa045122.31008735
7Cardiac muscle contraction_Homo sapiens_hsa042602.24056319
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.15010303
9Prion diseases_Homo sapiens_hsa050202.04574573
10Focal adhesion_Homo sapiens_hsa045102.02930672
11Adherens junction_Homo sapiens_hsa045202.01051208
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.94924364
13Propanoate metabolism_Homo sapiens_hsa006401.85158209
14Sulfur relay system_Homo sapiens_hsa041221.84109115
15Fatty acid degradation_Homo sapiens_hsa000711.79685101
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.65213593
17Parkinsons disease_Homo sapiens_hsa050121.63957508
18Leukocyte transendothelial migration_Homo sapiens_hsa046701.61632271
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.56806546
20Oxidative phosphorylation_Homo sapiens_hsa001901.55672418
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.53306540
22Tight junction_Homo sapiens_hsa045301.50423136
23Dorso-ventral axis formation_Homo sapiens_hsa043201.49309453
24Renin secretion_Homo sapiens_hsa049241.44939626
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42776428
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38919441
27Rap1 signaling pathway_Homo sapiens_hsa040151.35431766
28Arginine biosynthesis_Homo sapiens_hsa002201.35157849
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35041547
30Phenylalanine metabolism_Homo sapiens_hsa003601.32055974
31Biosynthesis of amino acids_Homo sapiens_hsa012301.31899146
32Vascular smooth muscle contraction_Homo sapiens_hsa042701.29449001
33Fatty acid metabolism_Homo sapiens_hsa012121.27201148
34Insulin resistance_Homo sapiens_hsa049311.25826869
35Axon guidance_Homo sapiens_hsa043601.24776492
36Alzheimers disease_Homo sapiens_hsa050101.24532421
37Bladder cancer_Homo sapiens_hsa052191.23488960
38Viral myocarditis_Homo sapiens_hsa054161.23443674
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21486843
40VEGF signaling pathway_Homo sapiens_hsa043701.17365242
41Pentose phosphate pathway_Homo sapiens_hsa000301.17112542
42Notch signaling pathway_Homo sapiens_hsa043301.16336695
43Folate biosynthesis_Homo sapiens_hsa007901.15661955
44Amoebiasis_Homo sapiens_hsa051461.15646603
45PPAR signaling pathway_Homo sapiens_hsa033201.15536611
46Chronic myeloid leukemia_Homo sapiens_hsa052201.13515789
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12910411
48Bile secretion_Homo sapiens_hsa049761.04219786
49Small cell lung cancer_Homo sapiens_hsa052221.00403902
50Renal cell carcinoma_Homo sapiens_hsa052111.00086190
51MicroRNAs in cancer_Homo sapiens_hsa052060.99134196
52Gap junction_Homo sapiens_hsa045400.98859234
53Thyroid cancer_Homo sapiens_hsa052160.98171307
54HIF-1 signaling pathway_Homo sapiens_hsa040660.97993942
55Carbon metabolism_Homo sapiens_hsa012000.97300378
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.96679773
57Pyruvate metabolism_Homo sapiens_hsa006200.95896212
58Platelet activation_Homo sapiens_hsa046110.95427896
59Proteoglycans in cancer_Homo sapiens_hsa052050.95335807
60PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94528608
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.93628391
62Huntingtons disease_Homo sapiens_hsa050160.93446750
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91100496
64Protein digestion and absorption_Homo sapiens_hsa049740.89618936
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83826391
66Oxytocin signaling pathway_Homo sapiens_hsa049210.83440376
67Estrogen signaling pathway_Homo sapiens_hsa049150.83333010
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82515904
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81919507
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81557125
71Glioma_Homo sapiens_hsa052140.81499249
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79194037
73Tyrosine metabolism_Homo sapiens_hsa003500.75854125
74Gastric acid secretion_Homo sapiens_hsa049710.75778694
75African trypanosomiasis_Homo sapiens_hsa051430.75706562
76Fructose and mannose metabolism_Homo sapiens_hsa000510.75553556
77Galactose metabolism_Homo sapiens_hsa000520.74797432
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73401438
79Ras signaling pathway_Homo sapiens_hsa040140.73352295
80Melanogenesis_Homo sapiens_hsa049160.73134720
81Ovarian steroidogenesis_Homo sapiens_hsa049130.72503999
82Arginine and proline metabolism_Homo sapiens_hsa003300.71117678
83Pathways in cancer_Homo sapiens_hsa052000.70417545
84cAMP signaling pathway_Homo sapiens_hsa040240.70343014
85Pancreatic cancer_Homo sapiens_hsa052120.70100848
86Glucagon signaling pathway_Homo sapiens_hsa049220.70061683
87Tryptophan metabolism_Homo sapiens_hsa003800.68671080
88Hippo signaling pathway_Homo sapiens_hsa043900.66066777
89Toxoplasmosis_Homo sapiens_hsa051450.65504336
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64756547
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64552017
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64009385
93Circadian entrainment_Homo sapiens_hsa047130.63924373
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61982172
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60998303
96Malaria_Homo sapiens_hsa051440.60933317
97Complement and coagulation cascades_Homo sapiens_hsa046100.60665462
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60555779
99Lysine degradation_Homo sapiens_hsa003100.60246980
100Other glycan degradation_Homo sapiens_hsa005110.60008918
101Calcium signaling pathway_Homo sapiens_hsa040200.59739274
102AMPK signaling pathway_Homo sapiens_hsa041520.57891127
103Butanoate metabolism_Homo sapiens_hsa006500.57595113
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57213792
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55871450
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54931830
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54709012
108Insulin signaling pathway_Homo sapiens_hsa049100.53980367
109GnRH signaling pathway_Homo sapiens_hsa049120.53762805
110TGF-beta signaling pathway_Homo sapiens_hsa043500.53082639
111Basal cell carcinoma_Homo sapiens_hsa052170.52042734
112Salivary secretion_Homo sapiens_hsa049700.49080344
113Fatty acid elongation_Homo sapiens_hsa000620.48523995
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47662766
115Taste transduction_Homo sapiens_hsa047420.47509996
116Choline metabolism in cancer_Homo sapiens_hsa052310.46823750
117Thyroid hormone synthesis_Homo sapiens_hsa049180.46694796
118Endocytosis_Homo sapiens_hsa041440.46274601
119Cholinergic synapse_Homo sapiens_hsa047250.45746761
120Long-term potentiation_Homo sapiens_hsa047200.43579337
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.43122804
122Morphine addiction_Homo sapiens_hsa050320.42541670
123Circadian rhythm_Homo sapiens_hsa047100.41640818
124mTOR signaling pathway_Homo sapiens_hsa041500.41358997
125Pancreatic secretion_Homo sapiens_hsa049720.41208639
126Salmonella infection_Homo sapiens_hsa051320.40851502
127Hedgehog signaling pathway_Homo sapiens_hsa043400.38820715
128Fat digestion and absorption_Homo sapiens_hsa049750.38556585
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36650073
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36533361
131Insulin secretion_Homo sapiens_hsa049110.35744379
132Caffeine metabolism_Homo sapiens_hsa002320.35505586
133Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35339387

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