RASL11B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RASL11B is a member of the small GTPase protein family with a high degree of similarity to RAS (see HRAS, MIM 190020) proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)4.62297832
2regulation of gene silencing by miRNA (GO:0060964)4.62297832
3regulation of gene silencing by RNA (GO:0060966)4.62297832
4vocalization behavior (GO:0071625)4.49258467
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.40978719
6chromatin remodeling at centromere (GO:0031055)4.33241439
7synaptic vesicle exocytosis (GO:0016079)4.17996130
8establishment of integrated proviral latency (GO:0075713)4.14452439
9glutamate secretion (GO:0014047)4.12725395
10protein localization to synapse (GO:0035418)4.12263491
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.08599258
12CENP-A containing nucleosome assembly (GO:0034080)4.04105512
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.03796257
14locomotory exploration behavior (GO:0035641)4.03183193
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.92756593
16regulation of glutamate receptor signaling pathway (GO:1900449)3.89775864
17synaptic vesicle docking involved in exocytosis (GO:0016081)3.87909378
18L-serine metabolic process (GO:0006563)3.79795696
19glutamate receptor signaling pathway (GO:0007215)3.77185352
20ionotropic glutamate receptor signaling pathway (GO:0035235)3.76085651
21cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.75251882
22histone exchange (GO:0043486)3.75143129
23mitotic metaphase plate congression (GO:0007080)3.73671636
24synaptic vesicle maturation (GO:0016188)3.72318728
25neuronal action potential propagation (GO:0019227)3.64583282
26regulation of cell fate specification (GO:0042659)3.61011583
27neuron recognition (GO:0008038)3.60976248
28protein complex localization (GO:0031503)3.59298359
29DNA replication checkpoint (GO:0000076)3.55505361
30positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.55389559
31protein localization to kinetochore (GO:0034501)3.54075988
32neuron cell-cell adhesion (GO:0007158)3.53736515
33regulation of helicase activity (GO:0051095)3.53697193
34cardiac myofibril assembly (GO:0055003)3.52707038
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.51768133
36cell communication by electrical coupling (GO:0010644)3.50711839
37positive regulation of synapse maturation (GO:0090129)3.50490628
38regulation of dendritic spine morphogenesis (GO:0061001)3.46384801
39regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.46123461
40regulation of synaptic vesicle exocytosis (GO:2000300)3.44463113
41regulation of translation, ncRNA-mediated (GO:0045974)3.43251435
42negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.43251435
43negative regulation of translation, ncRNA-mediated (GO:0040033)3.43251435
44pre-miRNA processing (GO:0031054)3.43243515
45paraxial mesoderm development (GO:0048339)3.42322373
46regulation of neuronal synaptic plasticity (GO:0048168)3.41897702
47DNA replication-independent nucleosome organization (GO:0034724)3.39829857
48DNA replication-independent nucleosome assembly (GO:0006336)3.39829857
49axonal fasciculation (GO:0007413)3.39317267
50exploration behavior (GO:0035640)3.38919440
51synaptic transmission, glutamatergic (GO:0035249)3.36548395
52regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.35664067
53regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.35634505
54regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.35199441
55neuron-neuron synaptic transmission (GO:0007270)3.28900319
56positive regulation of catenin import into nucleus (GO:0035413)3.28427513
57DNA strand elongation involved in DNA replication (GO:0006271)3.28008319
58dendritic spine morphogenesis (GO:0060997)3.27340375
59heterochromatin organization (GO:0070828)3.27077493
60metaphase plate congression (GO:0051310)3.26844146
61negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.26030677
62negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.26030677
63negative regulation of mitotic sister chromatid segregation (GO:0033048)3.26030677
64negative regulation of mitotic sister chromatid separation (GO:2000816)3.26030677
65negative regulation of sister chromatid segregation (GO:0033046)3.26030677
66lung-associated mesenchyme development (GO:0060484)3.24963015
67regulation of centriole replication (GO:0046599)3.23995920
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.22939903
69regulation of mitotic spindle checkpoint (GO:1903504)3.22939903
70positive regulation of SMAD protein import into nucleus (GO:0060391)3.21452655
71cell fate commitment involved in formation of primary germ layer (GO:0060795)3.21243760
72layer formation in cerebral cortex (GO:0021819)3.20632336
73somatic hypermutation of immunoglobulin genes (GO:0016446)3.20487488
74somatic diversification of immune receptors via somatic mutation (GO:0002566)3.20487488
75IMP biosynthetic process (GO:0006188)3.19372267
76negative regulation of chromosome segregation (GO:0051985)3.18824327
77regulation of excitatory postsynaptic membrane potential (GO:0060079)3.16855882
78gamma-aminobutyric acid signaling pathway (GO:0007214)3.16761751
79regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.16251256
80regulation of dendritic spine development (GO:0060998)3.13226490
81regulation of synapse structural plasticity (GO:0051823)3.12347347
82regulation of synaptic vesicle transport (GO:1902803)3.11552459
83generation of neurons (GO:0048699)3.11294313
84negative regulation of protein localization to cell surface (GO:2000009)3.09181605
85DNA strand elongation (GO:0022616)3.08549908
86positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.08348454
87regulation of synaptic plasticity (GO:0048167)3.08247854
88negative regulation of cell fate commitment (GO:0010454)3.07282217
89regulation of voltage-gated calcium channel activity (GO:1901385)3.07177061
90positive regulation of neurotransmitter secretion (GO:0001956)3.06282097
91membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.05330716
92G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04886456
93nodal signaling pathway (GO:0038092)3.03069110
94regulation of postsynaptic membrane potential (GO:0060078)3.01274161
95establishment of viral latency (GO:0019043)3.01258966
96neurotransmitter-gated ion channel clustering (GO:0072578)2.99099270
97DNA replication-dependent nucleosome assembly (GO:0006335)2.97588629
98DNA replication-dependent nucleosome organization (GO:0034723)2.97588629
99long-term synaptic potentiation (GO:0060291)2.97231173
100chaperone-mediated protein transport (GO:0072321)2.95570566
101DNA double-strand break processing (GO:0000729)2.94104522
102protein localization to chromosome, centromeric region (GO:0071459)2.92926983
103dendritic spine organization (GO:0097061)2.90943217
104detection of calcium ion (GO:0005513)2.90478719
105cellular protein complex localization (GO:0034629)2.89976852
106regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.89747291
107DNA damage response, detection of DNA damage (GO:0042769)2.89417422
108spindle checkpoint (GO:0031577)2.89333419
109G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.88989332
110regulation of cell fate commitment (GO:0010453)2.87140839
111regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.86975004
112myofibril assembly (GO:0030239)2.86704357
113negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.86531140
114behavioral response to cocaine (GO:0048148)2.86315300
115regulation of non-canonical Wnt signaling pathway (GO:2000050)2.86118459
116presynaptic membrane assembly (GO:0097105)2.85287334
117mitotic spindle checkpoint (GO:0071174)2.85125348
118cellular potassium ion homeostasis (GO:0030007)2.84436581
119ATP-dependent chromatin remodeling (GO:0043044)2.83915661
120female gonad development (GO:0008585)2.83481385
121cell communication involved in cardiac conduction (GO:0086065)2.83323242
122cochlea development (GO:0090102)2.83312747
123synaptic vesicle endocytosis (GO:0048488)2.83095656
124regulation of mitotic sister chromatid separation (GO:0010965)2.83041808
125regulation of mitotic sister chromatid segregation (GO:0033047)2.83041808
126regulation of sister chromatid segregation (GO:0033045)2.83041808
127long-term memory (GO:0007616)2.82618425
128IMP metabolic process (GO:0046040)2.81589095
129negative regulation of mitosis (GO:0045839)2.81414688
130kinetochore organization (GO:0051383)2.81253002
131DNA unwinding involved in DNA replication (GO:0006268)2.80334199
132response to X-ray (GO:0010165)2.80307582
133regulation of mitotic metaphase/anaphase transition (GO:0030071)2.80182789
134regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.80182789
135presynaptic membrane organization (GO:0097090)2.79811335
136regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.77996115
137regulation of stem cell maintenance (GO:2000036)2.77548942
138kinetochore assembly (GO:0051382)2.77272414
139regulation of chromosome segregation (GO:0051983)2.76704290
140regulation of cell communication by electrical coupling (GO:0010649)2.74777175
141mitotic spindle assembly checkpoint (GO:0007094)2.73764188
142purine nucleobase biosynthetic process (GO:0009113)2.73180037
143negative regulation of synaptic transmission, GABAergic (GO:0032229)2.72813611
144negative regulation of DNA recombination (GO:0045910)2.71728422
145long term synaptic depression (GO:0060292)2.71286678
146negative regulation of DNA-dependent DNA replication (GO:2000104)2.70956382
147cerebellar granule cell differentiation (GO:0021707)2.70910672
148regulation of synapse maturation (GO:0090128)2.70773441
149regulation of calcium ion transmembrane transporter activity (GO:1901019)2.69769541
150regulation of calcium ion transmembrane transport (GO:1903169)2.69769541
151digestive tract morphogenesis (GO:0048546)2.68358299
152behavioral defense response (GO:0002209)2.68294277
153behavioral fear response (GO:0001662)2.68294277
154ventricular cardiac muscle cell development (GO:0055015)2.67882238
155neurotransmitter secretion (GO:0007269)2.67719824
156spindle assembly checkpoint (GO:0071173)2.67050382
157anterior/posterior axis specification, embryo (GO:0008595)2.66909024
158postsynaptic membrane organization (GO:0001941)2.66084510
159DNA ligation (GO:0006266)2.65902144
160innervation (GO:0060384)2.65901853
161ephrin receptor signaling pathway (GO:0048013)2.65825664
162positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.65494397
163positive regulation of membrane potential (GO:0045838)2.65403827
164sarcomere organization (GO:0045214)2.65056467
165positive regulation of dendritic spine development (GO:0060999)2.64519157
166regulation of membrane repolarization (GO:0060306)2.64384626
167membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.63347211
168telomere maintenance via semi-conservative replication (GO:0032201)2.63059751
169fear response (GO:0042596)2.62671261
170activation of protein kinase A activity (GO:0034199)2.62457860
171positive regulation of potassium ion transmembrane transport (GO:1901381)2.62379527
172negative regulation of cell fate specification (GO:0009996)2.61918796
173notochord development (GO:0030903)2.61690458
174cardiac muscle contraction (GO:0060048)2.59598732
175regulation of potassium ion transmembrane transport (GO:1901379)2.59208144
176sodium ion export (GO:0071436)2.58839337
177regulation of glutamate secretion (GO:0014048)2.58672128
178negative regulation of potassium ion transmembrane transport (GO:1901380)2.58573207
179mitotic G2/M transition checkpoint (GO:0044818)2.57879670
180regulation of sarcomere organization (GO:0060297)2.56585686
181transmission of nerve impulse (GO:0019226)2.56180740
182DNA replication initiation (GO:0006270)2.56085828
183regulation of gastrulation (GO:0010470)2.55407392
184negative regulation of nuclear division (GO:0051784)2.54403083
185positive regulation of neurotransmitter transport (GO:0051590)2.52864236
186mitotic sister chromatid segregation (GO:0000070)2.52012440
187nucleobase biosynthetic process (GO:0046112)2.51915777
188convergent extension (GO:0060026)2.51819431
189heart trabecula formation (GO:0060347)2.51415867
190positive regulation of dendrite development (GO:1900006)2.49801354
191regulation of nuclear cell cycle DNA replication (GO:0033262)2.49206819
192neuromuscular process controlling balance (GO:0050885)2.48725245
193sister chromatid segregation (GO:0000819)2.45537846
194regulation of cardioblast differentiation (GO:0051890)2.45528767
195regulation of gene silencing (GO:0060968)2.41743412
196histone arginine methylation (GO:0034969)2.41591629
197negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.41294676
198spliceosomal snRNP assembly (GO:0000387)2.40180109
199lysine metabolic process (GO:0006553)2.38830015
200lysine catabolic process (GO:0006554)2.38830015

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.09133190
2EZH2_22144423_ChIP-Seq_EOC_Human5.58809546
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.34136972
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.32945250
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.32177274
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.20148568
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18944210
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.10847362
9GBX2_23144817_ChIP-Seq_PC3_Human3.08065565
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.04714031
11POU5F1_16153702_ChIP-ChIP_HESCs_Human3.01686422
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.96339523
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.96339523
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.80265748
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.73337072
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.71147097
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.70703403
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.70272923
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.64647424
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61836420
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58354632
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.53391137
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.53391137
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.53391137
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51492654
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44604258
27* SOX2_16153702_ChIP-ChIP_HESCs_Human2.37986044
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36306718
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.32934724
30RBPJ_22232070_ChIP-Seq_NCS_Mouse2.32547023
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.28466542
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.27897341
33* NANOG_16153702_ChIP-ChIP_HESCs_Human2.25108660
34EST1_17652178_ChIP-ChIP_JURKAT_Human2.25092366
35EZH2_27294783_Chip-Seq_ESCs_Mouse2.24297549
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.20834729
37SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18772674
38* RARB_27405468_Chip-Seq_BRAIN_Mouse2.16135222
39GABP_17652178_ChIP-ChIP_JURKAT_Human2.12852750
40DROSHA_22980978_ChIP-Seq_HELA_Human2.12796648
41SALL1_21062744_ChIP-ChIP_HESCs_Human2.12706009
42* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09713963
43CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08202345
44AR_21909140_ChIP-Seq_LNCAP_Human2.08023225
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.01297131
46NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.01167794
47SOX2_18555785_ChIP-Seq_MESCs_Mouse2.00908156
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99728211
49REST_21632747_ChIP-Seq_MESCs_Mouse1.90462298
50TCF3_18692474_ChIP-Seq_MEFs_Mouse1.76759944
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.75632183
52AR_21572438_ChIP-Seq_LNCaP_Human1.72394910
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.69104722
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68796534
55* EP300_21415370_ChIP-Seq_HL-1_Mouse1.68499912
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67044905
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66535817
58* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66274393
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65049818
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.63098373
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62965058
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62582838
63* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62486266
64EWS_26573619_Chip-Seq_HEK293_Human1.59042143
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.58761250
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.58001668
67* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56441458
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53218847
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52982867
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52773490
71ELK1_19687146_ChIP-ChIP_HELA_Human1.51492488
72TAF15_26573619_Chip-Seq_HEK293_Human1.51173795
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50533742
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50014049
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49316002
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48756833
77* SMAD4_21799915_ChIP-Seq_A2780_Human1.48004424
78TCF3_18692474_ChIP-Seq_MESCs_Mouse1.47824568
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.47535878
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47399781
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47301961
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.47277474
83RING1B_27294783_Chip-Seq_ESCs_Mouse1.45367691
84TRIM28_21343339_ChIP-Seq_HEK293_Human1.44562551
85MYC_18940864_ChIP-ChIP_HL60_Human1.44072600
86GATA1_26923725_Chip-Seq_HPCs_Mouse1.43555872
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43280550
88TTF2_22483619_ChIP-Seq_HELA_Human1.41669906
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.40050570
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39386206
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39018401
92THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37810243
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36679381
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35924233
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34739213
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.34454477
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33865841
98TP63_19390658_ChIP-ChIP_HaCaT_Human1.33842691
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33327075
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.33088549
101P300_19829295_ChIP-Seq_ESCs_Human1.32590104
102* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32340267
103JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31994093
104POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31929080
105EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30877360
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30636353
107SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.30172408
108PIAS1_25552417_ChIP-Seq_VCAP_Human1.29249450
109ZNF274_21170338_ChIP-Seq_K562_Hela1.29017946
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28804034
111XRN2_22483619_ChIP-Seq_HELA_Human1.27322931
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26467595
113POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.26062148
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24251486
115FUS_26573619_Chip-Seq_HEK293_Human1.24178211
116RING1B_27294783_Chip-Seq_NPCs_Mouse1.23803777
117CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23561495
118ARNT_22903824_ChIP-Seq_MCF-7_Human1.23075738
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22986808
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22927194
121SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22890515
122* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21770374
123NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.21178011
124ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20779138
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19739075
126SOX2_21211035_ChIP-Seq_LN229_Gbm1.19333563
127NOTCH1_21737748_ChIP-Seq_TLL_Human1.18688431
128ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17747898
129ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16880865
130* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16579736
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16272282
132BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15700266
133AHR_22903824_ChIP-Seq_MCF-7_Human1.15095519
134ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14353167
135TP53_16413492_ChIP-PET_HCT116_Human1.13926760
136VDR_22108803_ChIP-Seq_LS180_Human1.11916523
137SMAD_19615063_ChIP-ChIP_OVARY_Human1.10675709
138* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10388114
139TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10141479
140TP53_20018659_ChIP-ChIP_R1E_Mouse1.10032030
141* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09960488
142AR_25329375_ChIP-Seq_VCAP_Human1.08786300
143CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08544641
144PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08010509
145AR_19668381_ChIP-Seq_PC3_Human1.07765673
146NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07090698
147GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06943221
148FOXP3_21729870_ChIP-Seq_TREG_Human1.05878094
149* TP53_18474530_ChIP-ChIP_U2OS_Human1.04428141
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04203537
151SOX2_18692474_ChIP-Seq_MEFs_Mouse1.04075584
152TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02124790
153TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01151882
154DCP1A_22483619_ChIP-Seq_HELA_Human1.00203799
155* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00179071
156* SMAD3_21741376_ChIP-Seq_HESCs_Human0.99416367
157DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99244622
158ESR1_20079471_ChIP-ChIP_T-47D_Human0.99029119
159* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97848200
160PRDM14_20953172_ChIP-Seq_ESCs_Human0.97023825
161* SMAD4_21741376_ChIP-Seq_HESCs_Human0.96597306
162NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96554909
163PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96392832
164* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.96138534
165STAT3_23295773_ChIP-Seq_U87_Human0.94729341
166KDM2B_26808549_Chip-Seq_K562_Human0.94421489
167NANOG_21062744_ChIP-ChIP_HESCs_Human0.93656854
168BCAT_22108803_ChIP-Seq_LS180_Human0.93592797
169ISL1_27105846_Chip-Seq_CPCs_Mouse0.92944257
170FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92797853
171ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91342203
172YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90904909
173TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90202638
174TCF4_23295773_ChIP-Seq_U87_Human0.89521948
175TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89373743
176ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89160722
177TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88713285
178POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88713285
179* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88360113
180FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88207796
181FLI1_27457419_Chip-Seq_LIVER_Mouse0.87659045
182SOX2_18692474_ChIP-Seq_MESCs_Mouse0.87636031
183POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87186981
184MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.87141297
185AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86379796
186SOX17_20123909_ChIP-Seq_XEN_Mouse0.86045272
187SOX9_26525672_Chip-Seq_HEART_Mouse0.85186174
188YY1_21170310_ChIP-Seq_MESCs_Mouse0.84879328

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.48097552
2MP0003880_abnormal_central_pattern4.60405108
3MP0002837_dystrophic_cardiac_calcinosis3.43050260
4MP0003941_abnormal_skin_development3.41648844
5MP0003635_abnormal_synaptic_transmissio3.31765831
6MP0010030_abnormal_orbit_morphology3.28761395
7MP0004270_analgesia2.91796341
8MP0008877_abnormal_DNA_methylation2.76459170
9MP0003693_abnormal_embryo_hatching2.74252462
10MP0002063_abnormal_learning/memory/cond2.69749231
11MP0000751_myopathy2.67183749
12MP0009745_abnormal_behavioral_response2.63673274
13MP0002254_reproductive_system_inflammat2.56998788
14MP0004957_abnormal_blastocyst_morpholog2.52922164
15MP0003136_yellow_coat_color2.45070767
16MP0002064_seizures2.36517159
17MP0001968_abnormal_touch/_nociception2.27296450
18MP0010094_abnormal_chromosome_stability2.24819092
19MP0004215_abnormal_myocardial_fiber2.20619911
20MP0008058_abnormal_DNA_repair2.19337610
21MP0004133_heterotaxia2.18980857
22MP0009780_abnormal_chondrocyte_physiolo2.16806594
23MP0003119_abnormal_digestive_system2.15722582
24MP0002572_abnormal_emotion/affect_behav2.12882069
25MP0006292_abnormal_olfactory_placode2.11142222
26MP0008932_abnormal_embryonic_tissue2.10414300
27MP0003111_abnormal_nucleus_morphology2.10160644
28MP0001293_anophthalmia2.07014549
29MP0001486_abnormal_startle_reflex2.06014808
30MP0003329_amyloid_beta_deposits2.05295822
31MP0002272_abnormal_nervous_system2.05032254
32MP0002102_abnormal_ear_morphology1.97922821
33MP0002736_abnormal_nociception_after1.96876170
34MP0004084_abnormal_cardiac_muscle1.95927512
35MP0003937_abnormal_limbs/digits/tail_de1.95880494
36MP0004484_altered_response_of1.95771501
37MP0009672_abnormal_birth_weight1.95657553
38MP0009046_muscle_twitch1.90395307
39MP0003077_abnormal_cell_cycle1.90280692
40MP0003890_abnormal_embryonic-extraembry1.86654037
41MP0004145_abnormal_muscle_electrophysio1.81250904
42MP0000566_synostosis1.78698291
43MP0002734_abnormal_mechanical_nocicepti1.77840168
44MP0005623_abnormal_meninges_morphology1.76823649
45MP0003567_abnormal_fetal_cardiomyocyte1.74957791
46MP0008057_abnormal_DNA_replication1.73594674
47MP0001440_abnormal_grooming_behavior1.73263576
48MP0004036_abnormal_muscle_relaxation1.69931785
49MP0003718_maternal_effect1.69218899
50MP0002697_abnormal_eye_size1.69049174
51MP0003137_abnormal_impulse_conducting1.66759076
52MP0000778_abnormal_nervous_system1.66677624
53MP0000049_abnormal_middle_ear1.61291144
54MP0001501_abnormal_sleep_pattern1.60061039
55MP0005330_cardiomyopathy1.59025384
56MP0000579_abnormal_nail_morphology1.57891143
57MP0004085_abnormal_heartbeat1.54038609
58MP0000749_muscle_degeneration1.53179014
59MP0002751_abnormal_autonomic_nervous1.53159648
60MP0002972_abnormal_cardiac_muscle1.49645367
61MP0003879_abnormal_hair_cell1.48093348
62MP0001286_abnormal_eye_development1.46360278
63MP0004885_abnormal_endolymph1.45281667
64MP0002735_abnormal_chemical_nociception1.44819213
65MP0002233_abnormal_nose_morphology1.44623739
66MP0002067_abnormal_sensory_capabilities1.44515039
67MP0003122_maternal_imprinting1.44011372
68MP0000428_abnormal_craniofacial_morphol1.41696267
69MP0005620_abnormal_muscle_contractility1.41627538
70MP0002085_abnormal_embryonic_tissue1.41463023
71MP0004858_abnormal_nervous_system1.41244179
72MP0001730_embryonic_growth_arrest1.38224330
73MP0008569_lethality_at_weaning1.35917187
74MP0008789_abnormal_olfactory_epithelium1.34417451
75MP0002084_abnormal_developmental_patter1.31944348
76MP0001299_abnormal_eye_distance/1.31893371
77MP0008007_abnormal_cellular_replicative1.31797601
78MP0009703_decreased_birth_body1.31479062
79MP0003646_muscle_fatigue1.31337572
80MP0002111_abnormal_tail_morphology1.30855237
81MP0002733_abnormal_thermal_nociception1.30801998
82MP0001970_abnormal_pain_threshold1.30360761
83MP0001188_hyperpigmentation1.30210911
84MP0002938_white_spotting1.28856875
85MP0005386_behavior/neurological_phenoty1.27520050
86MP0004924_abnormal_behavior1.27520050
87MP0005187_abnormal_penis_morphology1.26354084
88MP0002184_abnormal_innervation1.24693780
89MP0006138_congestive_heart_failure1.21981905
90MP0003121_genomic_imprinting1.21652731
91MP0003283_abnormal_digestive_organ1.21254617
92MP0003861_abnormal_nervous_system1.21131062
93MP0000516_abnormal_urinary_system1.20813129
94MP0005367_renal/urinary_system_phenotyp1.20813129
95MP0001346_abnormal_lacrimal_gland1.20264426
96MP0002557_abnormal_social/conspecific_i1.17322113
97MP0005423_abnormal_somatic_nervous1.16489814
98MP0004087_abnormal_muscle_fiber1.16275920
99MP0009250_abnormal_appendicular_skeleto1.14403591
100MP0004510_myositis1.14014260
101MP0000955_abnormal_spinal_cord1.13677131
102MP0004233_abnormal_muscle_weight1.13180019
103MP0001905_abnormal_dopamine_level1.11933097
104MP0004811_abnormal_neuron_physiology1.11588322
105MP0005499_abnormal_olfactory_system1.11221231
106MP0005394_taste/olfaction_phenotype1.11221231
107MP0003755_abnormal_palate_morphology1.11177588
108MP0001485_abnormal_pinna_reflex1.10839984
109MP0006072_abnormal_retinal_apoptosis1.10761284
110MP0005380_embryogenesis_phenotype1.09571486
111MP0001672_abnormal_embryogenesis/_devel1.09571486
112MP0002234_abnormal_pharynx_morphology1.08219144
113MP0002066_abnormal_motor_capabilities/c1.08013815
114MP0002822_catalepsy1.07953446
115MP0003938_abnormal_ear_development1.05416026
116MP0002882_abnormal_neuron_morphology1.04965781
117MP0002909_abnormal_adrenal_gland1.04225310
118MP0009053_abnormal_anal_canal1.04026621
119MP0003633_abnormal_nervous_system1.03410862
120MP0004197_abnormal_fetal_growth/weight/1.01857729
121MP0006276_abnormal_autonomic_nervous1.00566554
122MP0005385_cardiovascular_system_phenoty0.99326269
123MP0001544_abnormal_cardiovascular_syste0.99326269
124MP0000432_abnormal_head_morphology0.99108386
125MP0001697_abnormal_embryo_size0.98286397
126MP0002106_abnormal_muscle_physiology0.96631637
127MP0001529_abnormal_vocalization0.95327339
128MP0000350_abnormal_cell_proliferation0.95199549
129MP0005503_abnormal_tendon_morphology0.93368582
130MP0000631_abnormal_neuroendocrine_gland0.92980898
131MP0000747_muscle_weakness0.92888953
132MP0008775_abnormal_heart_ventricle0.92490755
133MP0003935_abnormal_craniofacial_develop0.92467426
134MP0002127_abnormal_cardiovascular_syste0.92218995
135MP0005369_muscle_phenotype0.91868597
136MP0003631_nervous_system_phenotype0.90968621
137MP0002090_abnormal_vision0.90507290
138MP0003123_paternal_imprinting0.89704772
139MP0002152_abnormal_brain_morphology0.88273061
140MP0003984_embryonic_growth_retardation0.87696250
141MP0000762_abnormal_tongue_morphology0.86794304
142MP0002088_abnormal_embryonic_growth/wei0.86676238
143MP0001984_abnormal_olfaction0.86413904
144MP0000462_abnormal_digestive_system0.85953636
145MP0010352_gastrointestinal_tract_polyps0.85745929
146MP0003787_abnormal_imprinting0.85649923
147MP0004272_abnormal_basement_membrane0.85403026
148MP0000013_abnormal_adipose_tissue0.85235192
149MP0001502_abnormal_circadian_rhythm0.84682332
150MP0001963_abnormal_hearing_physiology0.82097284
151MP0001177_atelectasis0.81578866
152MP0002080_prenatal_lethality0.81497915
153MP0000604_amyloidosis0.80500233
154MP0000759_abnormal_skeletal_muscle0.79574259
155MP0002116_abnormal_craniofacial_bone0.78609223
156MP0005171_absent_coat_pigmentation0.78094112
157MP0002081_perinatal_lethality0.78013679
158MP0000537_abnormal_urethra_morphology0.77629212
159MP0003315_abnormal_perineum_morphology0.77413389
160MP0005391_vision/eye_phenotype0.76971850
161MP0002092_abnormal_eye_morphology0.76871014
162MP0010630_abnormal_cardiac_muscle0.75702167
163MP0002653_abnormal_ependyma_morphology0.75557490
164MP0005377_hearing/vestibular/ear_phenot0.74899608
165MP0003878_abnormal_ear_physiology0.74899608
166MP0002210_abnormal_sex_determination0.74748725
167MP0004742_abnormal_vestibular_system0.74194799
168MP0000920_abnormal_myelination0.74156736
169MP0000647_abnormal_sebaceous_gland0.73544330
170MP0002269_muscular_atrophy0.72678095
171MP0006035_abnormal_mitochondrial_morpho0.72307815
172MP0002249_abnormal_larynx_morphology0.71729339
173MP0001145_abnormal_male_reproductive0.71722835
174MP0000026_abnormal_inner_ear0.70914587
175MP0000534_abnormal_ureter_morphology0.70622493
176MP0001958_emphysema0.69894896
177MP0008874_decreased_physiological_sensi0.69380789
178MP0002295_abnormal_pulmonary_circulatio0.68998556
179MP0003385_abnormal_body_wall0.67974877
180MP0004130_abnormal_muscle_cell0.67866758
181MP0005409_darkened_coat_color0.67682477

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.90009008
2Abnormality of the labia minora (HP:0012880)4.88211609
3Myokymia (HP:0002411)4.70581494
4Sudden death (HP:0001699)4.46126239
5Colon cancer (HP:0003003)4.43478089
6Focal seizures (HP:0007359)4.23556794
7Epileptic encephalopathy (HP:0200134)3.91867436
8Hyperventilation (HP:0002883)3.81376784
9Visual hallucinations (HP:0002367)3.70889903
10Septo-optic dysplasia (HP:0100842)3.67166960
11Cerebral inclusion bodies (HP:0100314)3.55224210
12Atonic seizures (HP:0010819)3.52396168
13Abnormality of the calf musculature (HP:0001430)3.31641458
14Syncope (HP:0001279)3.20344040
15Amblyopia (HP:0000646)3.11372228
16Calf muscle hypertrophy (HP:0008981)3.07709071
17Hepatoblastoma (HP:0002884)3.03318731
18Birth length less than 3rd percentile (HP:0003561)3.01768440
19Nuclear cataract (HP:0100018)2.99408843
20Atrial fibrillation (HP:0005110)2.96228801
21Neurofibrillary tangles (HP:0002185)2.95827843
22Broad-based gait (HP:0002136)2.94396365
23Muscle hypertrophy of the lower extremities (HP:0008968)2.90636721
24Primary atrial arrhythmia (HP:0001692)2.88589224
25Stenosis of the external auditory canal (HP:0000402)2.81520545
26Absence seizures (HP:0002121)2.77739554
27Nephroblastoma (Wilms tumor) (HP:0002667)2.74487853
28Abnormal lung lobation (HP:0002101)2.74222407
29Supraventricular tachycardia (HP:0004755)2.70566678
30Supraventricular arrhythmia (HP:0005115)2.68827738
31Ependymoma (HP:0002888)2.67858845
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.65478502
33Maternal diabetes (HP:0009800)2.64816816
34Generalized tonic-clonic seizures (HP:0002069)2.63820573
35Dialeptic seizures (HP:0011146)2.61709395
36Embryonal renal neoplasm (HP:0011794)2.60676189
37Ventricular fibrillation (HP:0001663)2.59089240
38Absent septum pellucidum (HP:0001331)2.58964760
39Exercise-induced myalgia (HP:0003738)2.58908220
40Bilateral microphthalmos (HP:0007633)2.58356992
41Choanal stenosis (HP:0000452)2.52432098
42Meckel diverticulum (HP:0002245)2.52327624
43Muscle fiber splitting (HP:0003555)2.52325292
44Bundle branch block (HP:0011710)2.52112559
45Dysmetria (HP:0001310)2.49552096
46Febrile seizures (HP:0002373)2.48826296
47Esophageal atresia (HP:0002032)2.46550284
48Spastic diplegia (HP:0001264)2.46072262
49Prolonged QT interval (HP:0001657)2.45309615
50Abnormality of the septum pellucidum (HP:0007375)2.45119211
51Breast aplasia (HP:0100783)2.44686888
52Abnormality of the ileum (HP:0001549)2.41916859
53Poor eye contact (HP:0000817)2.41828175
54Action tremor (HP:0002345)2.40807978
55Supranuclear gaze palsy (HP:0000605)2.40570081
56Chromsome breakage (HP:0040012)2.40372148
57Anxiety (HP:0000739)2.39921587
58Medulloblastoma (HP:0002885)2.38846628
59Abnormality of abdominal situs (HP:0011620)2.37851112
60Abdominal situs inversus (HP:0003363)2.37851112
61Aplasia/Hypoplasia of the breasts (HP:0010311)2.36950020
62Progressive cerebellar ataxia (HP:0002073)2.36791691
63Cortical dysplasia (HP:0002539)2.32678141
64EMG: myopathic abnormalities (HP:0003458)2.32603073
65Insidious onset (HP:0003587)2.30614510
66Termporal pattern (HP:0011008)2.30614510
67Agnosia (HP:0010524)2.29586846
68Zonular cataract (HP:0010920)2.27885695
69Pheochromocytoma (HP:0002666)2.26478330
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.25621367
71Dysdiadochokinesis (HP:0002075)2.24526673
72Partial duplication of thumb phalanx (HP:0009944)2.23832229
73Reticulocytopenia (HP:0001896)2.23323062
74Triphalangeal thumb (HP:0001199)2.22599857
75Partial duplication of the phalanx of hand (HP:0009999)2.21840899
76Abnormal number of incisors (HP:0011064)2.19401068
77Facial cleft (HP:0002006)2.18161059
78Absent radius (HP:0003974)2.17953767
79Drooling (HP:0002307)2.15115865
80Excessive salivation (HP:0003781)2.15115865
81Hyporeflexia of lower limbs (HP:0002600)2.13437854
82Depression (HP:0000716)2.11829161
83Ventricular arrhythmia (HP:0004308)2.11574534
84Acute necrotizing encephalopathy (HP:0006965)2.09719070
85Selective tooth agenesis (HP:0001592)2.08835521
86Absent forearm bone (HP:0003953)2.08718944
87Aplasia involving forearm bones (HP:0009822)2.08718944
88Anophthalmia (HP:0000528)2.07894676
89Aplasia/Hypoplasia of the sternum (HP:0006714)2.06064422
90Broad metatarsal (HP:0001783)2.05944453
91Ventricular tachycardia (HP:0004756)2.05718399
92Absent speech (HP:0001344)2.04098239
93Hypoplastic female external genitalia (HP:0012815)2.03718626
94Rapidly progressive (HP:0003678)2.03681166
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02478199
96Neuroendocrine neoplasm (HP:0100634)2.01159956
97Hydroureter (HP:0000072)2.00955217
98Abnormal social behavior (HP:0012433)2.00900517
99Impaired social interactions (HP:0000735)2.00900517
100Abnormal EKG (HP:0003115)2.00858635
101Bifid tongue (HP:0010297)2.00342497
102Abnormality of chromosome stability (HP:0003220)1.99183639
103Abnormality of the duodenum (HP:0002246)1.99147195
104Myelomeningocele (HP:0002475)1.98291042
105Labial hypoplasia (HP:0000066)1.97764192
106Rhabdomyosarcoma (HP:0002859)1.97260854
107Small intestinal stenosis (HP:0012848)1.96747566
108Duodenal stenosis (HP:0100867)1.96747566
109Cutaneous syndactyly (HP:0012725)1.96344960
110Supernumerary spleens (HP:0009799)1.96264408
111Impaired vibration sensation in the lower limbs (HP:0002166)1.95920287
112Right ventricular cardiomyopathy (HP:0011663)1.95315208
113Cutaneous finger syndactyly (HP:0010554)1.95074654
114Intestinal atresia (HP:0011100)1.94929025
115Hyperglycinemia (HP:0002154)1.94787391
116Increased variability in muscle fiber diameter (HP:0003557)1.94430891
117Buphthalmos (HP:0000557)1.93479569
118Gaze-evoked nystagmus (HP:0000640)1.92625348
119Abnormal mitochondria in muscle tissue (HP:0008316)1.90551390
120Optic nerve hypoplasia (HP:0000609)1.90417764
121Shallow orbits (HP:0000586)1.89670731
122Neoplasm of the colon (HP:0100273)1.89487198
123Gastrointestinal atresia (HP:0002589)1.88927296
124Myotonia (HP:0002486)1.88784554
125Lipoatrophy (HP:0100578)1.85902409
126Horseshoe kidney (HP:0000085)1.85578219
127Insomnia (HP:0100785)1.85156266
128Increased nuchal translucency (HP:0010880)1.84982143
129Megalencephaly (HP:0001355)1.83479580
130Short hallux (HP:0010109)1.83162129
131Exercise-induced muscle cramps (HP:0003710)1.83052622
132Double outlet right ventricle (HP:0001719)1.81906090
133Congenital malformation of the right heart (HP:0011723)1.81906090
134Delusions (HP:0000746)1.80952775
135Aqueductal stenosis (HP:0002410)1.80418954
136Ectopic kidney (HP:0000086)1.80205751
137Progressive macrocephaly (HP:0004481)1.79852730
138Hemiparesis (HP:0001269)1.78979967
139Lower limb amyotrophy (HP:0007210)1.78412602
140Diplopia (HP:0000651)1.77683825
141Abnormality of binocular vision (HP:0011514)1.77683825
142Abnormality of the preputium (HP:0100587)1.77171929
143Thickened helices (HP:0000391)1.76487782
144Aplasia/Hypoplasia of the hallux (HP:0008362)1.76454913
145Sensory axonal neuropathy (HP:0003390)1.75859053
146Dysmetric saccades (HP:0000641)1.75687601
147Abnormality of serum amino acid levels (HP:0003112)1.74256984
148Abnormality of the left ventricular outflow tract (HP:0011103)1.74237943
149Subaortic stenosis (HP:0001682)1.74237943
150Carpal bone hypoplasia (HP:0001498)1.74008981
151Abnormality of the lower motor neuron (HP:0002366)1.73385907
152Urinary urgency (HP:0000012)1.73045013
153Breast carcinoma (HP:0003002)1.72646507
154Vaginal atresia (HP:0000148)1.72287567
155Depressed nasal tip (HP:0000437)1.72038310
156Turricephaly (HP:0000262)1.71986399
157Ankle clonus (HP:0011448)1.71690550
158Stereotypic behavior (HP:0000733)1.71183439
159Aplasia involving bones of the upper limbs (HP:0009823)1.69540186
160Aplasia of the phalanges of the hand (HP:0009802)1.69540186
161Aplasia involving bones of the extremities (HP:0009825)1.69540186
162Duplication of thumb phalanx (HP:0009942)1.69047461
163Absent eyebrow (HP:0002223)1.68848182
164Heart block (HP:0012722)1.67932746
165Anencephaly (HP:0002323)1.67922364
166Pterygium (HP:0001059)1.67715539
167Patellar aplasia (HP:0006443)1.67381352
168Abnormal hair whorl (HP:0010721)1.67062647
169Incomplete penetrance (HP:0003829)1.65953887
170Epileptiform EEG discharges (HP:0011182)1.65777808
171Generalized hypotonia (HP:0001290)1.65711019
172Truncal ataxia (HP:0002078)1.65649957
173Rocker bottom foot (HP:0001838)1.65368313
174Morphological abnormality of the inner ear (HP:0011390)1.64780837
175Biliary tract neoplasm (HP:0100574)1.64493065
176Genital tract atresia (HP:0001827)1.64380521
177Renal hypoplasia (HP:0000089)1.64169606
178Preaxial foot polydactyly (HP:0001841)1.64129254
179Inability to walk (HP:0002540)1.63327056
180Lower limb asymmetry (HP:0100559)1.63192599
181Glioma (HP:0009733)1.62841693
182Vascular tortuosity (HP:0004948)1.62724729
183Arterial tortuosity (HP:0005116)1.62692394
184Abnormality of cochlea (HP:0000375)1.62532112
185Dandy-Walker malformation (HP:0001305)1.62468342
186Abnormality of the clitoris (HP:0000056)1.62378465
187Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.62367418
188Degeneration of the lateral corticospinal tracts (HP:0002314)1.62367418
189Truncus arteriosus (HP:0001660)1.61893577
190Neoplasm of the oral cavity (HP:0100649)1.61442431
191Scanning speech (HP:0002168)1.61371227
192Multiple enchondromatosis (HP:0005701)1.59720103
193Mixed hearing impairment (HP:0000410)1.58582169
194Neoplasm of the adrenal cortex (HP:0100641)1.58501891
195Shoulder girdle muscle weakness (HP:0003547)1.58327059
196Gastrointestinal carcinoma (HP:0002672)1.55054847
197Malignant gastrointestinal tract tumors (HP:0006749)1.55054847
198Abnormality of the astrocytes (HP:0100707)1.54881647

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.37362194
2BUB13.74944981
3CDC73.59121980
4NTRK33.33182402
5MKNK23.17517489
6SRPK12.97512964
7TTK2.75121382
8MKNK12.73646294
9MAP3K92.64602119
10DAPK22.62069727
11ERBB42.55095394
12TSSK62.53825296
13RIPK42.52170096
14MAP3K42.50061538
15BRSK22.46395580
16VRK22.45096125
17WEE12.42101977
18PLK32.32127480
19CASK2.29049742
20PLK22.28396657
21KSR22.08085399
22ZAK2.06425378
23MINK11.99352097
24TNIK1.99254060
25PTK2B1.98882213
26PLK41.97336868
27PAK61.91876574
28TAF11.83003306
29MAP2K71.78209581
30KSR11.74517639
31PNCK1.74195155
32TRIM281.74139283
33DMPK1.73325484
34MAP3K121.61874415
35CDK191.60057202
36PLK11.57682520
37BRSK11.55735431
38PRKD31.54747220
39MYLK1.54606885
40MAP2K41.54136826
41DAPK11.50737821
42DYRK21.48390666
43GRK51.47721348
44VRK11.47206230
45STK38L1.46506467
46NUAK11.46465206
47LMTK21.44517716
48OXSR11.43858791
49WNK31.41945369
50MARK11.41650929
51BMPR21.40660010
52PBK1.35672032
53MAP3K101.29811830
54NME11.27517745
55CAMKK11.27287516
56ARAF1.27150110
57CAMK2A1.26937276
58NTRK11.25156588
59GRK11.25035700
60LATS21.21758280
61CSNK1G11.21602229
62PHKG21.20557561
63PHKG11.20557561
64CDK51.19933503
65DYRK31.19687817
66STK161.16569740
67PAK31.16027273
68DAPK31.13833320
69CAMK2B1.13483532
70PRPF4B1.12251788
71STK391.10674125
72NEK11.10006346
73SIK21.09641104
74FGR1.07908290
75STK31.04951245
76BRD41.04770724
77LATS11.03477349
78UHMK11.02931820
79DDR21.02866299
80ATR1.01814756
81TYRO31.01812080
82WNK41.01343855
83ALK1.00504253
84TTN0.99949538
85STK380.99679057
86RAF10.98350829
87ROCK20.97360533
88CHEK20.95826862
89MAP3K130.95627058
90PRKCG0.95224426
91NTRK20.93132376
92PASK0.92254015
93CSNK1G30.91614121
94CAMK10.89503240
95CAMK2D0.86891221
96FGFR10.86838363
97ADRBK20.83566868
98SGK4940.81569393
99SGK2230.81569393
100AURKB0.79294373
101CAMKK20.75491163
102MUSK0.75214740
103MAPK130.75003231
104BMPR1B0.74980780
105FER0.73114488
106STK110.71392030
107CSNK1A1L0.70770201
108PRKCE0.70735324
109MAPK120.70584491
110MAP3K20.70184599
111CDK180.69784536
112MAP3K70.69580236
113CDK140.69376760
114SGK10.68241617
115ATM0.67975250
116CDK150.67556028
117ILK0.64795461
118CHEK10.63702250
119CAMK1D0.63316509
120DYRK1A0.63301504
121NEK20.62133701
122PKN10.60770340
123NLK0.59898481
124CCNB10.59490812
125PINK10.59170880
126PDK30.58740312
127PDK40.58740312
128OBSCN0.58711176
129CAMK2G0.58415803
130GRK60.57996186
131CDK11A0.56732625
132CSNK1E0.55914719
133EPHB20.55342057
134PAK40.55223420
135INSRR0.54545863
136TAOK10.54453374
137PIK3CA0.54265399
138TIE10.54000909
139PDPK10.53263651
140MAP2K10.53009867
141WNK10.52839465
142PRKCH0.52139365
143PRKD10.51928403
144RET0.51729513
145BCR0.51245513
146CDC42BPA0.51058771
147CDK70.50292165
148FLT30.50185171
149STK240.50120765
150CAMK40.49898725
151FGFR20.49271381
152PDGFRA0.49036623
153CDK20.48020807
154CDK10.47998539
155CDK30.45749629
156AURKA0.45579134
157RPS6KA40.44809389
158ROCK10.44358376
159TGFBR10.43913585
160CSNK1G20.43426816
161PRKDC0.42440655
162EIF2AK30.42412591
163CAMK1G0.42346906
164MST40.41358303
165EIF2AK20.39435140
166CSNK2A10.38460465
167MELK0.37410193
168CSNK2A20.32708989
169STK40.32133525
170ACVR1B0.29925929
171CSNK1A10.29879395
172BRAF0.29791038

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.54240209
2DNA replication_Homo sapiens_hsa030303.31678342
3Nicotine addiction_Homo sapiens_hsa050333.00220907
4Proteasome_Homo sapiens_hsa030502.83375560
5Long-term potentiation_Homo sapiens_hsa047202.71314619
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.56108460
7Circadian entrainment_Homo sapiens_hsa047132.51602278
8RNA polymerase_Homo sapiens_hsa030202.47986188
9Spliceosome_Homo sapiens_hsa030402.45641909
10Amphetamine addiction_Homo sapiens_hsa050312.39649657
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36030389
12Ribosome_Homo sapiens_hsa030102.32670238
13Cardiac muscle contraction_Homo sapiens_hsa042602.32089838
14Glutamatergic synapse_Homo sapiens_hsa047242.29865874
15Non-homologous end-joining_Homo sapiens_hsa034502.26337775
16Cell cycle_Homo sapiens_hsa041102.23014907
17RNA transport_Homo sapiens_hsa030132.22884202
18Synaptic vesicle cycle_Homo sapiens_hsa047212.18123462
19Base excision repair_Homo sapiens_hsa034102.17044560
20Salivary secretion_Homo sapiens_hsa049702.12102843
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11950431
22Cysteine and methionine metabolism_Homo sapiens_hsa002702.05123312
23Selenocompound metabolism_Homo sapiens_hsa004502.03261366
24Morphine addiction_Homo sapiens_hsa050322.00617507
25Vitamin B6 metabolism_Homo sapiens_hsa007502.00249253
26GABAergic synapse_Homo sapiens_hsa047271.99541180
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96637816
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.96045149
29Olfactory transduction_Homo sapiens_hsa047401.91976770
30Fanconi anemia pathway_Homo sapiens_hsa034601.91491318
31Gastric acid secretion_Homo sapiens_hsa049711.89996392
32Dopaminergic synapse_Homo sapiens_hsa047281.89877974
33Renin secretion_Homo sapiens_hsa049241.88216568
34Homologous recombination_Homo sapiens_hsa034401.87374322
35Dilated cardiomyopathy_Homo sapiens_hsa054141.82247382
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79881173
37Oxytocin signaling pathway_Homo sapiens_hsa049211.78537538
38Oxidative phosphorylation_Homo sapiens_hsa001901.76543016
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75872253
40RNA degradation_Homo sapiens_hsa030181.75790941
41Calcium signaling pathway_Homo sapiens_hsa040201.72016897
42One carbon pool by folate_Homo sapiens_hsa006701.68655151
43Alzheimers disease_Homo sapiens_hsa050101.65283544
44Taste transduction_Homo sapiens_hsa047421.64530825
45Insulin secretion_Homo sapiens_hsa049111.62235459
46mRNA surveillance pathway_Homo sapiens_hsa030151.61999909
47Long-term depression_Homo sapiens_hsa047301.60027392
48Basal transcription factors_Homo sapiens_hsa030221.58844620
49Cholinergic synapse_Homo sapiens_hsa047251.54032716
50Parkinsons disease_Homo sapiens_hsa050121.52241250
51Nucleotide excision repair_Homo sapiens_hsa034201.46763287
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.46610748
53Serotonergic synapse_Homo sapiens_hsa047261.46177432
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44014687
55GnRH signaling pathway_Homo sapiens_hsa049121.41819944
56Gap junction_Homo sapiens_hsa045401.41715288
57p53 signaling pathway_Homo sapiens_hsa041151.39048320
58Axon guidance_Homo sapiens_hsa043601.38206656
59Melanogenesis_Homo sapiens_hsa049161.37725833
60cGMP-PKG signaling pathway_Homo sapiens_hsa040221.37268498
61Collecting duct acid secretion_Homo sapiens_hsa049661.35637269
62Pyruvate metabolism_Homo sapiens_hsa006201.35300447
63Biosynthesis of amino acids_Homo sapiens_hsa012301.34455079
64Protein export_Homo sapiens_hsa030601.31158066
65Steroid biosynthesis_Homo sapiens_hsa001001.30749043
66cAMP signaling pathway_Homo sapiens_hsa040241.28028235
67Cocaine addiction_Homo sapiens_hsa050301.26388482
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26007312
69TGF-beta signaling pathway_Homo sapiens_hsa043501.24613434
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23584757
71Propanoate metabolism_Homo sapiens_hsa006401.23469054
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22457824
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20725475
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18726207
75Vascular smooth muscle contraction_Homo sapiens_hsa042701.18238109
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18204477
77Pyrimidine metabolism_Homo sapiens_hsa002401.17660833
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12249285
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09325636
80Estrogen signaling pathway_Homo sapiens_hsa049151.09284127
81Glioma_Homo sapiens_hsa052141.07272588
82Huntingtons disease_Homo sapiens_hsa050161.05020432
83Purine metabolism_Homo sapiens_hsa002300.98813157
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98049480
85Vibrio cholerae infection_Homo sapiens_hsa051100.90399641
86ErbB signaling pathway_Homo sapiens_hsa040120.85097397
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83404537
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82583477
89VEGF signaling pathway_Homo sapiens_hsa043700.81105036
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80927957
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79905216
92Glucagon signaling pathway_Homo sapiens_hsa049220.79406817
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78938141
94Oocyte meiosis_Homo sapiens_hsa041140.78029189
95Dorso-ventral axis formation_Homo sapiens_hsa043200.77608974
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76825056
97Carbon metabolism_Homo sapiens_hsa012000.76503509
98Wnt signaling pathway_Homo sapiens_hsa043100.76152050
99Pancreatic secretion_Homo sapiens_hsa049720.75845677
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.75382536
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74855801
102Fatty acid elongation_Homo sapiens_hsa000620.73038798
103Vitamin digestion and absorption_Homo sapiens_hsa049770.72526973
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71801827
105Thyroid hormone synthesis_Homo sapiens_hsa049180.71312526
106Type II diabetes mellitus_Homo sapiens_hsa049300.70387593
107Rap1 signaling pathway_Homo sapiens_hsa040150.69726033
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67236151
109MAPK signaling pathway_Homo sapiens_hsa040100.67140978
110Choline metabolism in cancer_Homo sapiens_hsa052310.66966447
111Arginine and proline metabolism_Homo sapiens_hsa003300.66606558
112Hedgehog signaling pathway_Homo sapiens_hsa043400.66300066
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65767694
114Tight junction_Homo sapiens_hsa045300.64085182
115Renal cell carcinoma_Homo sapiens_hsa052110.63523712
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62503427
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62302943
118Ras signaling pathway_Homo sapiens_hsa040140.61732641
119Sulfur relay system_Homo sapiens_hsa041220.59785657
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58563936
121Adherens junction_Homo sapiens_hsa045200.58493409
122Focal adhesion_Homo sapiens_hsa045100.56886639
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56530685
124Hippo signaling pathway_Homo sapiens_hsa043900.55500016
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54968385
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53220060
127Folate biosynthesis_Homo sapiens_hsa007900.51955367
128MicroRNAs in cancer_Homo sapiens_hsa052060.51434177
129Glutathione metabolism_Homo sapiens_hsa004800.50861801
130Thyroid cancer_Homo sapiens_hsa052160.50814991
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50557238
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50081742
133ECM-receptor interaction_Homo sapiens_hsa045120.47015921
134Metabolic pathways_Homo sapiens_hsa011000.46792421
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46465342
136Basal cell carcinoma_Homo sapiens_hsa052170.46315030
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45461527
138Lysine degradation_Homo sapiens_hsa003100.44447464
139Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44290022
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.43796479
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43768242
142African trypanosomiasis_Homo sapiens_hsa051430.42447201
143Circadian rhythm_Homo sapiens_hsa047100.42199265
144Colorectal cancer_Homo sapiens_hsa052100.41833248
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40084788
146Protein digestion and absorption_Homo sapiens_hsa049740.39820543
147Neurotrophin signaling pathway_Homo sapiens_hsa047220.39521529
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38615966
149mTOR signaling pathway_Homo sapiens_hsa041500.35903752
150Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35613206
151Insulin signaling pathway_Homo sapiens_hsa049100.35308163
152Amoebiasis_Homo sapiens_hsa051460.35033284
153Proteoglycans in cancer_Homo sapiens_hsa052050.34508688
154Ovarian steroidogenesis_Homo sapiens_hsa049130.33929982
155Phototransduction_Homo sapiens_hsa047440.33635187
156Inositol phosphate metabolism_Homo sapiens_hsa005620.31751628
157Prion diseases_Homo sapiens_hsa050200.30402382
158Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29212097
159Alcoholism_Homo sapiens_hsa050340.28431128
160Melanoma_Homo sapiens_hsa052180.26590054
161Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24940288
162Arginine biosynthesis_Homo sapiens_hsa002200.24611062
163beta-Alanine metabolism_Homo sapiens_hsa004100.23324380
164Central carbon metabolism in cancer_Homo sapiens_hsa052300.22673319
165Caffeine metabolism_Homo sapiens_hsa002320.20023763
166Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16626360
167Galactose metabolism_Homo sapiens_hsa000520.15030610

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