RASL12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)6.45792041
2glomerulus development (GO:0032835)6.24103310
3regulation of sequestering of triglyceride (GO:0010889)5.91844169
4lung vasculature development (GO:0060426)5.10665981
5mesenchymal cell differentiation involved in kidney development (GO:0072161)5.09190432
6mesenchymal cell differentiation involved in renal system development (GO:2001012)5.09190432
7cardiac muscle hypertrophy in response to stress (GO:0014898)5.02996122
8muscle hypertrophy in response to stress (GO:0003299)5.02996122
9cardiac muscle adaptation (GO:0014887)5.02996122
10protein heterotrimerization (GO:0070208)4.89733928
11respiratory tube development (GO:0030323)4.85588443
12cardiac muscle hypertrophy (GO:0003300)4.84330106
13retina vasculature morphogenesis in camera-type eye (GO:0061299)4.73704973
14cell differentiation involved in metanephros development (GO:0072202)4.61847410
15striated muscle hypertrophy (GO:0014897)4.59675572
16white fat cell differentiation (GO:0050872)4.52849766
17vascular endothelial growth factor signaling pathway (GO:0038084)4.48425729
18glomerular filtration (GO:0003094)4.40665020
19carnitine shuttle (GO:0006853)4.25041424
20diaphragm development (GO:0060539)4.23696932
21myofibril assembly (GO:0030239)4.16775263
22atrioventricular valve morphogenesis (GO:0003181)4.15094712
23fatty acid transmembrane transport (GO:1902001)4.14215126
24sex determination (GO:0007530)4.08845458
25muscle filament sliding (GO:0030049)4.07603854
26actin-myosin filament sliding (GO:0033275)4.07603854
27potassium ion import (GO:0010107)4.05474165
28muscle hypertrophy (GO:0014896)4.04259463
29renal filtration (GO:0097205)4.01115241
30regulation of actin filament-based movement (GO:1903115)3.90673493
31cGMP-mediated signaling (GO:0019934)3.90210940
32low-density lipoprotein particle clearance (GO:0034383)3.89282300
33regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.86519196
34metanephric mesenchyme development (GO:0072075)3.85740897
35glomerular basement membrane development (GO:0032836)3.84300164
36regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.74663263
37brown fat cell differentiation (GO:0050873)3.72954908
38cGMP biosynthetic process (GO:0006182)3.70830155
39Notch signaling involved in heart development (GO:0061314)3.68467812
40positive regulation of smooth muscle cell migration (GO:0014911)3.62410620
41skeletal muscle organ development (GO:0060538)3.60981646
42actin-mediated cell contraction (GO:0070252)3.57214752
43cardiac cell development (GO:0055006)3.53744239
44cell proliferation involved in metanephros development (GO:0072203)3.51052681
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.50661543
46negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.49758573
47kidney mesenchyme development (GO:0072074)3.49552780
48cardiac right ventricle morphogenesis (GO:0003215)3.47804543
49carnitine transmembrane transport (GO:1902603)3.47634831
50regulation of relaxation of muscle (GO:1901077)3.47423916
51sarcomere organization (GO:0045214)3.47394520
52extracellular matrix assembly (GO:0085029)3.42813229
53regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.42077103
54positive regulation of cardiac muscle cell proliferation (GO:0060045)3.38204539
55positive regulation of fatty acid oxidation (GO:0046321)3.35400493
56regulation of cardiac muscle cell contraction (GO:0086004)3.34768061
57biotin metabolic process (GO:0006768)3.33220176
58cell migration involved in heart development (GO:0060973)3.33170686
59relaxation of smooth muscle (GO:0044557)3.32328340
60cardiac muscle cell development (GO:0055013)3.31739516
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31606829
62lipid particle organization (GO:0034389)3.31267653
63relaxation of muscle (GO:0090075)3.29751411
64triglyceride catabolic process (GO:0019433)3.29041810
65positive regulation of metanephros development (GO:0072216)3.28145331
66positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.27095851
67cell proliferation involved in kidney development (GO:0072111)3.26592688
68lymph vessel development (GO:0001945)3.26523738
69striated muscle adaptation (GO:0014888)3.25409392
70heart valve morphogenesis (GO:0003179)3.24125821
71positive regulation of cardiac muscle tissue growth (GO:0055023)3.23661549
72positive regulation of male gonad development (GO:2000020)3.20904041
73regulation of skeletal muscle contraction (GO:0014819)3.20236425
74sarcoplasmic reticulum calcium ion transport (GO:0070296)3.17729620
75ventricular cardiac muscle cell development (GO:0055015)3.17038198
76induction of positive chemotaxis (GO:0050930)3.17010524
77fibroblast migration (GO:0010761)3.16500966
78smooth muscle tissue development (GO:0048745)3.16310550
79aorta morphogenesis (GO:0035909)3.16043424
80dermatan sulfate biosynthetic process (GO:0030208)3.16024279
81amino-acid betaine transport (GO:0015838)3.14513046
82carnitine transport (GO:0015879)3.14513046
83cell communication by electrical coupling (GO:0010644)3.13645405
84fatty acid beta-oxidation (GO:0006635)3.11534981
85cell-substrate adherens junction assembly (GO:0007045)3.11477979
86focal adhesion assembly (GO:0048041)3.11477979
87positive regulation of fatty acid beta-oxidation (GO:0032000)3.10687290
88cardiac muscle contraction (GO:0060048)3.10061340
89negative regulation of cytosolic calcium ion concentration (GO:0051481)3.09269361
90smooth muscle cell differentiation (GO:0051145)3.08047484
91mesenchyme morphogenesis (GO:0072132)3.07506473
92positive regulation of catenin import into nucleus (GO:0035413)3.06942848
93peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.06453464
94endothelium development (GO:0003158)3.04277650
95heart trabecula formation (GO:0060347)3.02538490
96regulation of cardioblast differentiation (GO:0051890)3.01527470
97extracellular fibril organization (GO:0043206)2.98803816
98adherens junction assembly (GO:0034333)2.98801379
99endocardial cushion morphogenesis (GO:0003203)2.97665852
100positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.97532368
101actomyosin structure organization (GO:0031032)2.95335485
102limb bud formation (GO:0060174)2.94305663
103negative regulation of androgen receptor signaling pathway (GO:0060766)2.94288010
104regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.93242951
105germ cell migration (GO:0008354)2.92755354
106cellular hyperosmotic response (GO:0071474)2.92052483
107dermatan sulfate metabolic process (GO:0030205)2.92010521
108adult heart development (GO:0007512)2.91919926
109sodium ion export (GO:0071436)2.90678151
110cGMP metabolic process (GO:0046068)2.89221489
111lung morphogenesis (GO:0060425)2.89201502
112triglyceride biosynthetic process (GO:0019432)2.88708027
113myelination in peripheral nervous system (GO:0022011)2.88062032
114peripheral nervous system axon ensheathment (GO:0032292)2.88062032
115lymphangiogenesis (GO:0001946)2.87798510
116acylglycerol biosynthetic process (GO:0046463)2.87381471
117neutral lipid biosynthetic process (GO:0046460)2.87381471
118cell volume homeostasis (GO:0006884)2.86605409
119positive regulation of heart growth (GO:0060421)2.83891808
120mesenchymal cell development (GO:0014031)2.83451792
121regulation of cholesterol storage (GO:0010885)2.81904971
122growth hormone receptor signaling pathway (GO:0060396)2.81839421
123regulation of fatty acid oxidation (GO:0046320)2.81720036
124cyclic purine nucleotide metabolic process (GO:0052652)2.81068407
125positive regulation of cardiac muscle tissue development (GO:0055025)2.80598840
126cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.80391003
127muscle contraction (GO:0006936)2.80335049
128tonic smooth muscle contraction (GO:0014820)2.79135009
129cyclic nucleotide catabolic process (GO:0009214)2.78493121
130negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.78400706
131regulation of male gonad development (GO:2000018)2.77987638
132fatty-acyl-CoA biosynthetic process (GO:0046949)2.76994770
133import into cell (GO:0098657)2.76981385
134striated muscle contraction (GO:0006941)2.76243533
135ovulation from ovarian follicle (GO:0001542)2.75321054
136relaxation of cardiac muscle (GO:0055119)2.74842025
137muscle system process (GO:0003012)2.74377133
138thioester biosynthetic process (GO:0035384)2.74040340
139acyl-CoA biosynthetic process (GO:0071616)2.74040340
140valine metabolic process (GO:0006573)2.73566988
141neutral lipid catabolic process (GO:0046461)2.72417716
142acylglycerol catabolic process (GO:0046464)2.72417716
143basement membrane organization (GO:0071711)2.72397934
144long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.71771395
145negative regulation of smooth muscle cell differentiation (GO:0051151)2.71497560
146astrocyte development (GO:0014002)2.71127966
147atrial septum morphogenesis (GO:0060413)2.70335013
148paraxial mesoderm development (GO:0048339)2.69921678
149SMAD protein signal transduction (GO:0060395)2.69207304
150membrane raft organization (GO:0031579)2.68972299
151quaternary ammonium group transport (GO:0015697)2.67656939
152regulation of smooth muscle cell migration (GO:0014910)2.67513803
153long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.67124152
154regulation of acyl-CoA biosynthetic process (GO:0050812)2.66419915
155myelin maintenance (GO:0043217)2.66391803
156cyclic nucleotide biosynthetic process (GO:0009190)2.65395580
157actin filament-based movement (GO:0030048)2.65281230
158negative regulation of muscle contraction (GO:0045932)2.65279614
159regulation of endothelial cell differentiation (GO:0045601)2.65194281
160negative regulation of smooth muscle cell proliferation (GO:0048662)2.64843822
161cAMP catabolic process (GO:0006198)2.64671106
162fatty-acyl-CoA metabolic process (GO:0035337)2.64550522
163regulation of cell communication by electrical coupling (GO:0010649)2.64290989
164cardiac epithelial to mesenchymal transition (GO:0060317)2.64081040
165positive regulation of calcium ion import (GO:0090280)2.63660066
166cardiac myofibril assembly (GO:0055003)2.62498463
167regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.62275137
168regulation of striated muscle contraction (GO:0006942)2.61899393
169regulation of axon extension involved in axon guidance (GO:0048841)2.61500041
170epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.60319971
171gamma-aminobutyric acid transport (GO:0015812)2.58874043
172regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.58798761
173embryonic digestive tract morphogenesis (GO:0048557)2.58566027
174cardiac muscle tissue morphogenesis (GO:0055008)2.58274067
175positive regulation of SMAD protein import into nucleus (GO:0060391)2.55998880
176positive regulation of macrophage cytokine production (GO:0060907)2.55815302
177phagocytosis, recognition (GO:0006910)2.55108900
178neural crest cell development (GO:0014032)2.53458219
179vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.53327773
180positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.52012386
181cellular response to growth hormone stimulus (GO:0071378)2.50774674
182regulation of gonadotropin secretion (GO:0032276)2.50247140
183branched-chain amino acid catabolic process (GO:0009083)2.49575551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.48202550
2CLOCK_20551151_ChIP-Seq_293T_Human3.11503333
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.81168724
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.59120256
5ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.52529718
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.43931617
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.40530208
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38040667
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.33909312
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22774914
11GBX2_23144817_ChIP-Seq_PC3_Human2.16453501
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.10405655
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05422342
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.03962596
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03180798
16CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.93045512
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89506762
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88635357
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88635357
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86231711
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86223696
22PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.85712013
23RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.82869907
24CJUN_26792858_Chip-Seq_BT549_Human1.81558393
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.78425049
26* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76494236
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76467493
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.73395406
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.70756918
30* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68831312
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.68774885
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65640325
33CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.64157140
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.61787951
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.61621958
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58999945
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57521479
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.53234520
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44861571
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44725952
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43484789
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40162115
43KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38825599
44KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38825599
45KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38825599
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.38043479
47TBX20_22328084_ChIP-Seq_HEART_Mouse1.37562836
48TBX20_22080862_ChIP-Seq_HEART_Mouse1.37562836
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37145255
50NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37145255
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35507208
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35332604
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.33869474
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.32852674
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.31971597
56EZH2_22144423_ChIP-Seq_EOC_Human1.31398563
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.30456855
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29599080
59* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29454211
60TP63_17297297_ChIP-ChIP_HaCaT_Human1.29260192
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27770496
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27553109
63MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25400968
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24964743
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.23850051
66NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23386290
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.23257176
68TP53_18474530_ChIP-ChIP_U2OS_Human1.23028334
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.21551117
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20499659
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.19596808
72BCAT_22108803_ChIP-Seq_LS180_Human1.18924241
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18731638
74TBX3_20139965_ChIP-Seq_MESCs_Mouse1.18588951
75TBX3_20139965_ChIP-Seq_ESCs_Mouse1.18209669
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17752722
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17720293
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.17402618
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17378036
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.17130138
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16828418
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14939265
83RNF2_27304074_Chip-Seq_NSC_Mouse1.14729483
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14426875
85PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.14004819
86TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12212243
87AR_21572438_ChIP-Seq_LNCaP_Human1.11298173
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11171927
89TP53_20018659_ChIP-ChIP_R1E_Mouse1.10193217
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10071564
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10044938
92ISL1_27105846_Chip-Seq_CPCs_Mouse1.07125259
93ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06777746
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06547474
95ER_23166858_ChIP-Seq_MCF-7_Human1.06302473
96PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.05779939
97CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05693548
98SMAD4_21799915_ChIP-Seq_A2780_Human1.03996095
99AHR_22903824_ChIP-Seq_MCF-7_Human1.03381844
100DROSHA_22980978_ChIP-Seq_HELA_Human1.02096448
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01999997
102GATA1_22025678_ChIP-Seq_K562_Human1.01766104
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01107238
104NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99635470
105SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99005165
106SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97681565
107VDR_22108803_ChIP-Seq_LS180_Human0.96856026
108POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96849325
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94387650
110SOX2_20726797_ChIP-Seq_SW620_Human0.92232267
111LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91689325
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.91628379
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91025220
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.90659860
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90203214
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89886800
117* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89379550
118P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88533972
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87796411
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86535598
121NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85362560
122STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84309832
123SMAD3_21741376_ChIP-Seq_EPCs_Human0.82267732
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.81586957
125RXR_22108803_ChIP-Seq_LS180_Human0.80677213
126NR3C1_23031785_ChIP-Seq_PC12_Mouse0.79982463
127VDR_24787735_ChIP-Seq_THP-1_Human0.79564257
128SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79203937
129SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79203937
130POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79166646
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79093388
132RING1B_27294783_Chip-Seq_NPCs_Mouse0.77570974
133TCF4_18268006_ChIP-ChIP_LS174T_Human0.77532418

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.11340426
2MP0005670_abnormal_white_adipose5.02642810
3MP0004272_abnormal_basement_membrane3.66266925
4MP0000013_abnormal_adipose_tissue3.61623249
5MP0005666_abnormal_adipose_tissue3.49353089
6MP0004185_abnormal_adipocyte_glucose3.46754389
7MP0004130_abnormal_muscle_cell3.24529485
8MP0005375_adipose_tissue_phenotype2.97388738
9MP0000003_abnormal_adipose_tissue2.72552691
10MP0003646_muscle_fatigue2.63402275
11MP0005275_abnormal_skin_tensile2.62702189
12MP0008995_early_reproductive_senescence2.47816888
13MP0001661_extended_life_span2.46730237
14MP0001879_abnormal_lymphatic_vessel2.46363782
15MP0001958_emphysema2.42320256
16MP0009384_cardiac_valve_regurgitation2.39185165
17MP0006138_congestive_heart_failure2.34131260
18MP0005623_abnormal_meninges_morphology2.27432574
19MP0003279_aneurysm2.27345524
20MP0002295_abnormal_pulmonary_circulatio2.25517519
21MP0002009_preneoplasia2.25308950
22MP0000751_myopathy2.13895958
23MP0010368_abnormal_lymphatic_system2.03692813
24MP0003724_increased_susceptibility_to1.98975433
25MP0003828_pulmonary_edema1.97497480
26MP0003283_abnormal_digestive_organ1.93761385
27MP0002971_abnormal_brown_adipose1.79231072
28MP0010030_abnormal_orbit_morphology1.75935857
29MP0002837_dystrophic_cardiac_calcinosis1.74245709
30MP0005369_muscle_phenotype1.72994233
31MP0002106_abnormal_muscle_physiology1.72805491
32MP0002102_abnormal_ear_morphology1.70961378
33MP0003950_abnormal_plasma_membrane1.64683010
34MP0005595_abnormal_vascular_smooth1.59917206
35MP0008775_abnormal_heart_ventricle1.56605995
36MP0002269_muscular_atrophy1.55287755
37MP0003705_abnormal_hypodermis_morpholog1.55084260
38MP0005423_abnormal_somatic_nervous1.48955886
39MP0003119_abnormal_digestive_system1.48835951
40MP0005620_abnormal_muscle_contractility1.47807686
41MP0004036_abnormal_muscle_relaxation1.47541490
42MP0004084_abnormal_cardiac_muscle1.43883025
43MP0000747_muscle_weakness1.42942423
44MP0003045_fibrosis1.42440115
45MP0000767_abnormal_smooth_muscle1.39698418
46MP0004215_abnormal_myocardial_fiber1.37826531
47MP0005330_cardiomyopathy1.33988865
48MP0005503_abnormal_tendon_morphology1.33357358
49MP0005385_cardiovascular_system_phenoty1.32939889
50MP0001544_abnormal_cardiovascular_syste1.32939889
51MP0002254_reproductive_system_inflammat1.31021717
52MP0004134_abnormal_chest_morphology1.27772261
53MP0000343_altered_response_to1.27283464
54MP0005164_abnormal_response_to1.24183369
55MP0009115_abnormal_fat_cell1.24173497
56MP0005167_abnormal_blood-brain_barrier1.22368707
57MP0000750_abnormal_muscle_regeneration1.20735548
58MP0001299_abnormal_eye_distance/1.20022181
59MP0005171_absent_coat_pigmentation1.18305066
60MP0002133_abnormal_respiratory_system1.17910690
61MP0005388_respiratory_system_phenotype1.17910690
62MP0002972_abnormal_cardiac_muscle1.17796613
63MP0000230_abnormal_systemic_arterial1.17442519
64MP0004270_analgesia1.12891834
65MP0002166_altered_tumor_susceptibility1.12227471
66MP0003136_yellow_coat_color1.08346080
67MP0000762_abnormal_tongue_morphology1.07336689
68MP0002128_abnormal_blood_circulation1.06641166
69MP0003091_abnormal_cell_migration1.05034150
70MP0004087_abnormal_muscle_fiber1.04988573
71MP0004147_increased_porphyrin_level1.02999664
72MP0005334_abnormal_fat_pad1.02629999
73MP0003115_abnormal_respiratory_system1.02387112
74MP0000049_abnormal_middle_ear1.01257968
75MP0003878_abnormal_ear_physiology1.00275400
76MP0005377_hearing/vestibular/ear_phenot1.00275400
77MP0006054_spinal_hemorrhage0.98719920
78MP0009250_abnormal_appendicular_skeleto0.98690241
79MP0000534_abnormal_ureter_morphology0.98342551
80MP0000733_abnormal_muscle_development0.97501285
81MP0002925_abnormal_cardiovascular_devel0.97105015
82MP0000266_abnormal_heart_morphology0.95099574
83MP0005165_increased_susceptibility_to0.93968681
84MP0004484_altered_response_of0.92880312
85MP0003690_abnormal_glial_cell0.91348414
86MP0009278_abnormal_bone_marrow0.90460606
87MP0000749_muscle_degeneration0.90123263
88MP0000249_abnormal_blood_vessel0.89938547
89MP0002168_other_aberrant_phenotype0.89820749
90MP0010630_abnormal_cardiac_muscle0.89327296
91MP0002132_abnormal_respiratory_system0.88896313
92MP0008004_abnormal_stomach_pH0.88569983
93MP0000537_abnormal_urethra_morphology0.88332191
94MP0000516_abnormal_urinary_system0.88084014
95MP0005367_renal/urinary_system_phenotyp0.88084014
96MP0003137_abnormal_impulse_conducting0.87725539
97MP0001177_atelectasis0.87682127
98MP0005535_abnormal_body_temperature0.87321944
99MP0004510_myositis0.87065887
100MP0001614_abnormal_blood_vessel0.86237728
101MP0003566_abnormal_cell_adhesion0.86038867
102MP0001727_abnormal_embryo_implantation0.83982439
103MP0004742_abnormal_vestibular_system0.82402243
104MP0000462_abnormal_digestive_system0.82241798
105MP0002108_abnormal_muscle_morphology0.81875614
106MP0000163_abnormal_cartilage_morphology0.80670803
107MP0005508_abnormal_skeleton_morphology0.78954027
108MP0000920_abnormal_myelination0.78290655
109MP0002734_abnormal_mechanical_nocicepti0.76835489
110MP0002933_joint_inflammation0.76741674
111MP0002060_abnormal_skin_morphology0.76620050
112MP0004233_abnormal_muscle_weight0.76121859
113MP0001485_abnormal_pinna_reflex0.75657095
114MP0003948_abnormal_gas_homeostasis0.75183258
115MP0003935_abnormal_craniofacial_develop0.74670361
116MP0000759_abnormal_skeletal_muscle0.73320505
117MP0000428_abnormal_craniofacial_morphol0.73259781
118MP0002006_tumorigenesis0.72681665
119MP0002332_abnormal_exercise_endurance0.72572717
120MP0001986_abnormal_taste_sensitivity0.72241750
121MP0004085_abnormal_heartbeat0.72094478
122MP0004133_heterotaxia0.70762877
123MP0003942_abnormal_urinary_system0.70740333
124MP0002249_abnormal_larynx_morphology0.69908853
125MP0002282_abnormal_trachea_morphology0.68183927
126MP0009780_abnormal_chondrocyte_physiolo0.67775122
127MP0001664_abnormal_digestion0.67172850
128MP0003191_abnormal_cellular_cholesterol0.67038594
129MP0001175_abnormal_lung_morphology0.66854036
130MP0002970_abnormal_white_adipose0.66805869
131MP0004883_abnormal_blood_vessel0.64446566
132MP0001984_abnormal_olfaction0.63962135
133MP0003385_abnormal_body_wall0.63897337
134MP0004145_abnormal_muscle_electrophysio0.63590027
135MP0008569_lethality_at_weaning0.63230734
136MP0003941_abnormal_skin_development0.63135835
137MP0004858_abnormal_nervous_system0.62988961
138MP0001542_abnormal_bone_strength0.62679166
139MP0002127_abnormal_cardiovascular_syste0.62455640
140MP0002118_abnormal_lipid_homeostasis0.61923139

Predicted human phenotypes

RankGene SetZ-score
1Aortic dissection (HP:0002647)5.11859662
2Aortic aneurysm (HP:0004942)4.92996637
3Ankle contracture (HP:0006466)4.70188446
4Muscle fiber inclusion bodies (HP:0100299)4.64761982
5Nemaline bodies (HP:0003798)4.59197344
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.52686184
7Broad metatarsal (HP:0001783)4.49710642
8Increased variability in muscle fiber diameter (HP:0003557)4.25982984
9Bone cyst (HP:0012062)4.18151372
10Premature rupture of membranes (HP:0001788)4.07225725
11Type 1 muscle fiber predominance (HP:0003803)3.88917418
12Facial diplegia (HP:0001349)3.75824557
13Spinal rigidity (HP:0003306)3.75400370
14Oligomenorrhea (HP:0000876)3.74264791
15Pulmonary artery stenosis (HP:0004415)3.73385942
16Bundle branch block (HP:0011710)3.62089227
17Abnormality of the calf musculature (HP:0001430)3.61227406
18Abnormality of skeletal muscle fiber size (HP:0012084)3.58102616
19Muscle hypertrophy of the lower extremities (HP:0008968)3.52614337
20Short hallux (HP:0010109)3.51503720
21Stridor (HP:0010307)3.51347962
22Exercise-induced muscle cramps (HP:0003710)3.43354541
23Acanthosis nigricans (HP:0000956)3.42753054
24Hypoplasia of the iris (HP:0007676)3.38106586
25Calf muscle hypertrophy (HP:0008981)3.37934111
26Aplasia/Hypoplasia of the hallux (HP:0008362)3.25523313
27Nausea (HP:0002018)3.24677161
28Distal arthrogryposis (HP:0005684)3.17243888
29Cerebral aneurysm (HP:0004944)3.14897140
30Follicular hyperkeratosis (HP:0007502)3.02211599
31Protrusio acetabuli (HP:0003179)2.99966736
32Supraventricular arrhythmia (HP:0005115)2.97400971
33Mesangial abnormality (HP:0001966)2.95287245
34Gonadal dysgenesis (HP:0000133)2.94837960
35Vertebral arch anomaly (HP:0008438)2.92764422
36Primary atrial arrhythmia (HP:0001692)2.90301364
37Increased connective tissue (HP:0009025)2.85884405
38Prominent supraorbital ridges (HP:0000336)2.84007430
39Round ear (HP:0100830)2.81955365
40Abnormality of the ischium (HP:0003174)2.80042907
41Bladder diverticulum (HP:0000015)2.75155303
42Supraventricular tachycardia (HP:0004755)2.75100381
43EMG: myopathic abnormalities (HP:0003458)2.74962430
44Muscle fiber splitting (HP:0003555)2.72196581
45Soft skin (HP:0000977)2.69205815
46Difficulty running (HP:0009046)2.64858388
47Gonadotropin excess (HP:0000837)2.63797726
48Subaortic stenosis (HP:0001682)2.60810573
49Abnormality of the left ventricular outflow tract (HP:0011103)2.60810573
50Heart block (HP:0012722)2.54226121
51Periauricular skin pits (HP:0100277)2.52948974
52Preauricular pit (HP:0004467)2.52948974
53Aortic regurgitation (HP:0001659)2.48709677
54Slender build (HP:0001533)2.48168384
55Neoplasm of the heart (HP:0100544)2.46757334
56Hypoplastic heart (HP:0001961)2.45519494
57Distal lower limb muscle weakness (HP:0009053)2.42428541
58Premature skin wrinkling (HP:0100678)2.41553908
59Bell-shaped thorax (HP:0001591)2.41403239
60Abnormal atrioventricular conduction (HP:0005150)2.39958608
61Myoglobinuria (HP:0002913)2.39178572
62Venous insufficiency (HP:0005293)2.39124994
63Venous abnormality (HP:0002624)2.38906143
64Hypertriglyceridemia (HP:0002155)2.37235794
65Preaxial foot polydactyly (HP:0001841)2.36196689
66Lipoatrophy (HP:0100578)2.35529140
67Abnormality of fatty-acid metabolism (HP:0004359)2.33805033
68Muscle stiffness (HP:0003552)2.30488577
69Skin pits (HP:0100276)2.30125677
70Scapular winging (HP:0003691)2.29838305
71Hypoplastic left heart (HP:0004383)2.26944563
72Limited hip movement (HP:0008800)2.25434993
73Cerebral hemorrhage (HP:0001342)2.25009602
74Hyporeflexia of lower limbs (HP:0002600)2.24436963
75Overgrowth (HP:0001548)2.24143875
76Coronal craniosynostosis (HP:0004440)2.23562114
77Rectal prolapse (HP:0002035)2.22939922
78Myopathic facies (HP:0002058)2.22318532
79Rimmed vacuoles (HP:0003805)2.20285760
80Lymphangioma (HP:0100764)2.19276022
81Hematochezia (HP:0002573)2.18229979
82Mildly elevated creatine phosphokinase (HP:0008180)2.18006841
83Fibular hypoplasia (HP:0003038)2.17237377
84Myotonia (HP:0002486)2.16645497
85Syncope (HP:0001279)2.15140724
86Male infertility (HP:0003251)2.14357991
87Abnormality of dentin (HP:0010299)2.14139592
88Hyperglycinuria (HP:0003108)2.14082309
89Neonatal short-limb short stature (HP:0008921)2.13304072
90Exercise-induced myalgia (HP:0003738)2.13085387
91Dicarboxylic aciduria (HP:0003215)2.11954482
92Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11954482
93Asymmetric septal hypertrophy (HP:0001670)2.10733891
94Ulnar claw (HP:0001178)2.08267115
95Scotoma (HP:0000575)2.07296990
96Centrally nucleated skeletal muscle fibers (HP:0003687)2.06648455
97Right ventricular cardiomyopathy (HP:0011663)2.06337694
98Atrioventricular block (HP:0001678)2.05330274
99Hip contracture (HP:0003273)2.02666710
100Aplasia of the phalanges of the hand (HP:0009802)2.02368602
101Aplasia involving bones of the extremities (HP:0009825)2.02368602
102Aplasia involving bones of the upper limbs (HP:0009823)2.02368602
103Prolonged QT interval (HP:0001657)2.02078705
104Long toe (HP:0010511)2.01230391
105Bulbar palsy (HP:0001283)2.00184973
106Atrophic scars (HP:0001075)1.99673432
107Muscular dystrophy (HP:0003560)1.98558366
108Growth hormone excess (HP:0000845)1.98204087
109Partial duplication of thumb phalanx (HP:0009944)1.97246598
110Turricephaly (HP:0000262)1.97046654
111Anterior segment dysgenesis (HP:0007700)1.96997622
112Accelerated skeletal maturation (HP:0005616)1.96682795
113Atrial fibrillation (HP:0005110)1.95623860
114Abnormality of Sharpey fibers (HP:0100685)1.95007333
115Abnormality of the foot musculature (HP:0001436)1.94316882
116Neck muscle weakness (HP:0000467)1.93079290
117Hydroxyprolinuria (HP:0003080)1.92761394
118Abnormality of proline metabolism (HP:0010907)1.92761394
119Large hands (HP:0001176)1.92599534
120Duplicated collecting system (HP:0000081)1.92424131
121Hemiplegia (HP:0002301)1.91447500
122Male pseudohermaphroditism (HP:0000037)1.90828131
123Chondrocalcinosis (HP:0000934)1.90360800
124Gowers sign (HP:0003391)1.89216538
125Increased muscle lipid content (HP:0009058)1.89102851
126Nasolacrimal duct obstruction (HP:0000579)1.88629689
127Transposition of the great arteries (HP:0001669)1.87396143
128Abnormal connection of the cardiac segments (HP:0011545)1.87396143
129Abnormal ventriculo-arterial connection (HP:0011563)1.87396143
130Partial duplication of the phalanx of hand (HP:0009999)1.87204225
131Shallow orbits (HP:0000586)1.87106255
132Ventricular arrhythmia (HP:0004308)1.86870355
133Aneurysm (HP:0002617)1.86337277
134Dilated cardiomyopathy (HP:0001644)1.85690552
135Broad hallux (HP:0010055)1.84655131
136Vascular tortuosity (HP:0004948)1.84145806
137Absent toe (HP:0010760)1.83344777
138Ventricular tachycardia (HP:0004756)1.82873484
139Wide anterior fontanel (HP:0000260)1.81832994
140Patent foramen ovale (HP:0001655)1.81252658
141Hyperpituitarism (HP:0010514)1.81168130
142Areflexia of lower limbs (HP:0002522)1.80976111
143Dilatation of the ascending aorta (HP:0005111)1.80788843
144Rhabdomyolysis (HP:0003201)1.80210036
145Foot dorsiflexor weakness (HP:0009027)1.80011141
146Abnormality of incisor morphology (HP:0011063)1.78777365
147Hypoplastic ischia (HP:0003175)1.78541878
148Ulnar deviation of the wrist (HP:0003049)1.78332863
149Gingival overgrowth (HP:0000212)1.77630461
150Abnormality of the pulmonary veins (HP:0011718)1.77090775
151Limb-girdle muscle weakness (HP:0003325)1.76029541
152Sudden death (HP:0001699)1.75112315
153Abnormality of glycine metabolism (HP:0010895)1.73637675
154Abnormality of serine family amino acid metabolism (HP:0010894)1.73637675
155Ventricular fibrillation (HP:0001663)1.73499060
156Obstructive sleep apnea (HP:0002870)1.73280007
157Delayed closure of the anterior fontanelle (HP:0001476)1.73213497
158Synostosis involving the elbow (HP:0003938)1.72537057
159Humeroradial synostosis (HP:0003041)1.72537057
160EMG: neuropathic changes (HP:0003445)1.72441757
161Large for gestational age (HP:0001520)1.71948682
162Xerostomia (HP:0000217)1.71730061
163Abnormality of the shoulder girdle musculature (HP:0001435)1.71647008

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK5.96758789
2EPHA34.19390043
3TIE14.13855349
4CAMK1D3.78211764
5PDGFRA3.26510526
6NTRK12.75084489
7TTN2.73781957
8CAMK1G2.71278745
9TAF12.42152912
10TRIB32.28732618
11FGFR22.26679427
12NTRK32.15587553
13MUSK2.10854479
14KIT2.10032145
15TGFBR22.06891696
16DMPK2.04092536
17NTRK22.01431709
18PDK41.89372754
19PDK31.89372754
20PTK2B1.88052151
21MAPK121.85306198
22PIK3CA1.84157152
23EPHB11.75318946
24EPHB21.71088119
25PDGFRB1.63795504
26MET1.62706913
27LATS21.62143414
28MAPK151.62060835
29STK391.59610462
30BCKDK1.58048803
31PDK21.47245150
32ILK1.40488549
33STK38L1.39056290
34ZAK1.38595439
35MAPK71.34449528
36PAK21.31876425
37RIPK11.30249921
38DDR21.22879032
39PIK3CG1.15757295
40PKN11.15400774
41TYRO31.12917487
42DAPK31.09837942
43EEF2K1.08192954
44BCR1.06458855
45PINK11.05095450
46CDK91.05049846
47MARK11.03890750
48ROCK10.99756279
49PRKD30.97823882
50NLK0.96321541
51LMTK20.94954736
52FER0.88403662
53KSR20.86890421
54OXSR10.86744412
55MAPKAPK30.85997347
56STK110.85670440
57SGK20.84019636
58PNCK0.84000318
59AKT30.83759265
60CDC42BPA0.83677372
61MAP3K70.83509353
62FRK0.82372400
63MAPK40.80275882
64PRKAA20.79257796
65GSK3A0.77921196
66WNK10.76787495
67LATS10.74215525
68MAPKAPK50.72819074
69PHKG20.70568646
70PHKG10.70568646
71WNK40.69571592
72SIK10.68867629
73RPS6KA20.68779869
74PRKD10.67397147
75MAP2K10.66553672
76PRKCE0.66319505
77LIMK10.66148952
78ADRBK10.65489696
79GRK10.65236408
80AKT20.63889121
81GRK50.62821759
82ABL20.62361928
83MAP3K100.61593989
84CAMK10.61520699
85FGFR30.60529150
86CAMK2A0.60380442
87PAK30.60118254
88UHMK10.59367055
89PRKCH0.58143687
90RPS6KC10.56513443
91RPS6KL10.56513443
92CAMK2G0.55163424
93NEK90.55028620
94INSR0.54936991
95DYRK1B0.54456277
96GRK70.54160038
97ERBB40.53859023
98BMX0.52254678
99PTK20.51926951
100ROCK20.50843210
101MAP3K20.49873377
102RPS6KA60.48934198
103TNIK0.46687727
104CAMK2D0.46080774
105DAPK20.45625548
106MAPK100.45585649
107SGK2230.44402157
108SGK4940.44402157
109CASK0.44371136
110SGK30.43964681
111FGR0.43191547
112NUAK10.42623526
113CAMK2B0.42533582
114CSNK1A1L0.41018399
115PRKAA10.40914037
116MARK20.40799497
117MAPK130.40354409
118NEK60.40098860
119STK380.39912112
120RET0.39803432
121SGK10.38949034
122IGF1R0.38287570
123NME10.38221511
124PAK10.37446332
125STK240.37320261
126OBSCN0.36924982
127ZAP700.36819055
128RPS6KA30.36765053
129PTK60.35713143
130PRKACA0.35711912
131TRPM70.34715571
132CSK0.33816841
133FGFR10.33084349
134IRAK20.33015494
135TGFBR10.32711123
136PRKG20.32576505
137MAPKAPK20.32060782
138INSRR0.31614193
139FGFR40.30707394
140KDR0.30442709
141PRKG10.29950741
142ERN10.29349469
143PRKD20.28523191
144ABL10.27828785
145PRKACG0.27539222
146SRC0.26856477
147PAK40.26600716

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.61501640
2Fatty acid metabolism_Homo sapiens_hsa012123.56258457
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.37883730
4Fatty acid biosynthesis_Homo sapiens_hsa000613.32894980
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.15843934
6Fatty acid elongation_Homo sapiens_hsa000623.15019610
7PPAR signaling pathway_Homo sapiens_hsa033203.07370614
8Fatty acid degradation_Homo sapiens_hsa000712.87979029
9ECM-receptor interaction_Homo sapiens_hsa045122.74290326
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.69956814
11Focal adhesion_Homo sapiens_hsa045102.06085754
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.99159453
13Histidine metabolism_Homo sapiens_hsa003401.84519197
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.81890621
15Renin secretion_Homo sapiens_hsa049241.74775437
16Vascular smooth muscle contraction_Homo sapiens_hsa042701.65600552
17Adipocytokine signaling pathway_Homo sapiens_hsa049201.47305713
18Protein digestion and absorption_Homo sapiens_hsa049741.46369860
19Dilated cardiomyopathy_Homo sapiens_hsa054141.37846011
20Glycerolipid metabolism_Homo sapiens_hsa005611.36568644
21Insulin secretion_Homo sapiens_hsa049111.32381776
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31357688
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31082007
24Amoebiasis_Homo sapiens_hsa051461.28646209
25cGMP-PKG signaling pathway_Homo sapiens_hsa040221.28142559
26Bile secretion_Homo sapiens_hsa049761.21206412
27Pyruvate metabolism_Homo sapiens_hsa006201.20831697
28Estrogen signaling pathway_Homo sapiens_hsa049151.20238431
29Axon guidance_Homo sapiens_hsa043601.19367722
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11338039
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10816608
32AMPK signaling pathway_Homo sapiens_hsa041521.06239773
33Tight junction_Homo sapiens_hsa045301.04265187
34ABC transporters_Homo sapiens_hsa020101.03883194
35Caffeine metabolism_Homo sapiens_hsa002321.03585112
36beta-Alanine metabolism_Homo sapiens_hsa004101.02933479
37PI3K-Akt signaling pathway_Homo sapiens_hsa041511.02205900
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01887481
39Arginine and proline metabolism_Homo sapiens_hsa003301.00969718
40Small cell lung cancer_Homo sapiens_hsa052221.00735996
41Leukocyte transendothelial migration_Homo sapiens_hsa046700.98904123
42TGF-beta signaling pathway_Homo sapiens_hsa043500.98536262
43Long-term depression_Homo sapiens_hsa047300.95364377
44Melanogenesis_Homo sapiens_hsa049160.94370704
45GnRH signaling pathway_Homo sapiens_hsa049120.94193894
46cAMP signaling pathway_Homo sapiens_hsa040240.93031893
47GABAergic synapse_Homo sapiens_hsa047270.93031550
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92501061
49Circadian rhythm_Homo sapiens_hsa047100.91915416
50Insulin resistance_Homo sapiens_hsa049310.91730986
51Ovarian steroidogenesis_Homo sapiens_hsa049130.91343032
52Pancreatic secretion_Homo sapiens_hsa049720.90302696
53Glutamatergic synapse_Homo sapiens_hsa047240.89804054
54Platelet activation_Homo sapiens_hsa046110.89132066
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87283010
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86432901
57Butanoate metabolism_Homo sapiens_hsa006500.84889960
58Amphetamine addiction_Homo sapiens_hsa050310.83484858
59Dorso-ventral axis formation_Homo sapiens_hsa043200.83307853
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81930673
61Malaria_Homo sapiens_hsa051440.80484164
62Long-term potentiation_Homo sapiens_hsa047200.79544562
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79329347
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79256803
65Prion diseases_Homo sapiens_hsa050200.78945414
66Mineral absorption_Homo sapiens_hsa049780.78011649
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77730814
68Carbon metabolism_Homo sapiens_hsa012000.76485785
69Adherens junction_Homo sapiens_hsa045200.76329793
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76314101
71Thyroid hormone synthesis_Homo sapiens_hsa049180.76010408
72Glioma_Homo sapiens_hsa052140.75747696
73Cholinergic synapse_Homo sapiens_hsa047250.75677732
74Complement and coagulation cascades_Homo sapiens_hsa046100.75209163
75Gap junction_Homo sapiens_hsa045400.74405539
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73396114
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71652203
78Rap1 signaling pathway_Homo sapiens_hsa040150.71564704
79Notch signaling pathway_Homo sapiens_hsa043300.71520561
80Pathways in cancer_Homo sapiens_hsa052000.71503845
81Cocaine addiction_Homo sapiens_hsa050300.71164887
82Alzheimers disease_Homo sapiens_hsa050100.70835117
83Parkinsons disease_Homo sapiens_hsa050120.70143030
84Oxidative phosphorylation_Homo sapiens_hsa001900.69239042
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68835494
86Viral myocarditis_Homo sapiens_hsa054160.68040430
87Phenylalanine metabolism_Homo sapiens_hsa003600.67793551
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67350934
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66753646
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.64847571
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63923463
92Wnt signaling pathway_Homo sapiens_hsa043100.63452836
93Serotonergic synapse_Homo sapiens_hsa047260.63351752
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62663574
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62573961
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61822679
97Proteoglycans in cancer_Homo sapiens_hsa052050.60986982
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60713807
99Peroxisome_Homo sapiens_hsa041460.58796269
100Oxytocin signaling pathway_Homo sapiens_hsa049210.57705707
101Melanoma_Homo sapiens_hsa052180.57539302
102Vitamin digestion and absorption_Homo sapiens_hsa049770.56703277
103Salivary secretion_Homo sapiens_hsa049700.55791701
104Nitrogen metabolism_Homo sapiens_hsa009100.55748820
105Renal cell carcinoma_Homo sapiens_hsa052110.55530351
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55134228
107Inositol phosphate metabolism_Homo sapiens_hsa005620.55079154
108Olfactory transduction_Homo sapiens_hsa047400.54973377
109Cardiac muscle contraction_Homo sapiens_hsa042600.54478055
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53986815
111Choline metabolism in cancer_Homo sapiens_hsa052310.53778536
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53571476
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53341805
114Toxoplasmosis_Homo sapiens_hsa051450.52948104
115Lysine degradation_Homo sapiens_hsa003100.52948044
116Ras signaling pathway_Homo sapiens_hsa040140.52748082
117Basal cell carcinoma_Homo sapiens_hsa052170.48823736
118Insulin signaling pathway_Homo sapiens_hsa049100.48571625
119Dopaminergic synapse_Homo sapiens_hsa047280.47980581
120Gastric acid secretion_Homo sapiens_hsa049710.47744865
121Hedgehog signaling pathway_Homo sapiens_hsa043400.46458024
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.45989288
123Glucagon signaling pathway_Homo sapiens_hsa049220.45813616
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45492422
125Tryptophan metabolism_Homo sapiens_hsa003800.45320657
126Hippo signaling pathway_Homo sapiens_hsa043900.45087317
127Prostate cancer_Homo sapiens_hsa052150.44788738
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44313575
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43684060
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42621319
131Huntingtons disease_Homo sapiens_hsa050160.41734438
132Calcium signaling pathway_Homo sapiens_hsa040200.40435726
133Arachidonic acid metabolism_Homo sapiens_hsa005900.39136187
134Rheumatoid arthritis_Homo sapiens_hsa053230.38587360
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36291961
136Sulfur metabolism_Homo sapiens_hsa009200.36203725
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.33614670
138Morphine addiction_Homo sapiens_hsa050320.33137823
139Autoimmune thyroid disease_Homo sapiens_hsa053200.32949028
140Sphingolipid metabolism_Homo sapiens_hsa006000.32127312
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29679364
142Circadian entrainment_Homo sapiens_hsa047130.28304784
143Fat digestion and absorption_Homo sapiens_hsa049750.26608250
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.26410400

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