RASSF10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1labyrinthine layer development (GO:0060711)8.18042644
2pyrimidine nucleoside salvage (GO:0043097)7.56225025
3pyrimidine-containing compound salvage (GO:0008655)7.56225025
4deoxyribonucleoside monophosphate metabolic process (GO:0009162)7.36800806
5striated muscle cell proliferation (GO:0014855)6.49931163
6pattern specification involved in kidney development (GO:0061004)6.10597962
7lateral sprouting from an epithelium (GO:0060601)5.90873629
8establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)5.74506046
9nucleoside salvage (GO:0043174)5.27616893
10response to copper ion (GO:0046688)5.19628939
11muscle cell proliferation (GO:0033002)5.13676059
12cilium or flagellum-dependent cell motility (GO:0001539)4.92292349
13desmosome organization (GO:0002934)4.88237590
14axonemal dynein complex assembly (GO:0070286)4.81555596
15neuronal stem cell maintenance (GO:0097150)4.67874383
16keratinocyte proliferation (GO:0043616)4.35621554
17establishment of skin barrier (GO:0061436)4.25756243
18establishment of planar polarity (GO:0001736)4.25544130
19establishment of tissue polarity (GO:0007164)4.25544130
20mitotic nuclear envelope reassembly (GO:0007084)4.23562194
21nuclear envelope reassembly (GO:0031468)4.23562194
22bundle of His cell to Purkinje myocyte communication (GO:0086069)4.16365898
23regulation of water loss via skin (GO:0033561)4.10951281
24establishment or maintenance of bipolar cell polarity (GO:0061245)4.04708953
25establishment or maintenance of apical/basal cell polarity (GO:0035088)4.04708953
26trophectodermal cell differentiation (GO:0001829)4.00383550
27regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.97792911
28notochord development (GO:0030903)3.94324812
29regulation of mesoderm development (GO:2000380)3.93696711
30negative regulation of catenin import into nucleus (GO:0035414)3.93302970
31cilium movement (GO:0003341)3.88768733
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.86138957
33calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.84709902
34protein maturation by protein folding (GO:0022417)3.81707780
35segment specification (GO:0007379)3.80123907
36exocrine pancreas development (GO:0031017)3.72513198
37GDP-mannose metabolic process (GO:0019673)3.62105799
38limb bud formation (GO:0060174)3.62081816
39planar cell polarity pathway involved in neural tube closure (GO:0090179)3.57852251
40locomotory exploration behavior (GO:0035641)3.56352853
41response to hepatocyte growth factor (GO:0035728)3.54161748
42cellular response to hepatocyte growth factor stimulus (GO:0035729)3.54161748
43nucleoside diphosphate catabolic process (GO:0009134)3.53048991
44hair follicle development (GO:0001942)3.49233709
45response to pheromone (GO:0019236)3.48530034
46regulation of type B pancreatic cell apoptotic process (GO:2000674)3.44476161
47negative regulation of keratinocyte proliferation (GO:0010839)3.44187497
48regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.41038085
49regulation of cell proliferation involved in kidney development (GO:1901722)3.39070799
50negative regulation of oligodendrocyte differentiation (GO:0048715)3.35889623
51cell migration involved in gastrulation (GO:0042074)3.35245781
52glomerular visceral epithelial cell development (GO:0072015)3.34690109
53surfactant homeostasis (GO:0043129)3.33983251
54epidermis development (GO:0008544)3.31657886
55renal system development (GO:0072001)3.29242355
56inner ear receptor cell differentiation (GO:0060113)3.27486178
57multicellular organismal water homeostasis (GO:0050891)3.27092165
58endocrine pancreas development (GO:0031018)3.26113562
59negative regulation of axon extension involved in axon guidance (GO:0048843)3.25496212
60neuron fate determination (GO:0048664)3.25281975
61negative regulation of chondrocyte differentiation (GO:0032331)3.24690035
62mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.21309596
63nucleotide transmembrane transport (GO:1901679)3.20686564
64sequestering of metal ion (GO:0051238)3.18540650
65keratinization (GO:0031424)3.18513599
66nephron tubule morphogenesis (GO:0072078)3.18426413
67nephron epithelium morphogenesis (GO:0072088)3.18426413
68asymmetric protein localization (GO:0008105)3.17559268
69diol metabolic process (GO:0034311)3.15962502
70negative regulation of activin receptor signaling pathway (GO:0032926)3.15662926
71negative regulation of cell fate specification (GO:0009996)3.15645016
72negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.15641783
73auditory receptor cell differentiation (GO:0042491)3.15142213
74radial glial cell differentiation (GO:0060019)3.14137663
75positive regulation of protein export from nucleus (GO:0046827)3.13896649
76mechanoreceptor differentiation (GO:0042490)3.13007785
77neural crest cell development (GO:0014032)3.12198441
78atrioventricular valve morphogenesis (GO:0003181)3.10830619
79negative regulation of astrocyte differentiation (GO:0048712)3.10359438
80regulation of glucan biosynthetic process (GO:0010962)3.07923541
81regulation of glycogen biosynthetic process (GO:0005979)3.07923541
82embryonic foregut morphogenesis (GO:0048617)3.07220000
83regulation of endothelial cell chemotaxis (GO:2001026)3.06158050
84positive regulation of neurological system process (GO:0031646)3.05849720
85primitive streak formation (GO:0090009)3.03770621
86telencephalon development (GO:0021537)3.02202070
87establishment of apical/basal cell polarity (GO:0035089)3.02144367
88epithelial cilium movement (GO:0003351)3.01667115
89cell surface receptor signaling pathway involved in heart development (GO:0061311)3.01620182
90cellular glucuronidation (GO:0052695)3.01467550
91maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.98887413
92dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.97985825
93glomerular epithelial cell development (GO:0072310)2.97496081
94regulation of keratinocyte proliferation (GO:0010837)2.97428568
95establishment of epithelial cell polarity (GO:0090162)2.97121999
96G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.94848584
97heart valve formation (GO:0003188)2.94779491
98germ cell migration (GO:0008354)2.94434584
99regulation of glomerulus development (GO:0090192)2.93210905
100dorsal/ventral axis specification (GO:0009950)2.92613190
101transmission of nerve impulse (GO:0019226)2.92268196
102digestive tract morphogenesis (GO:0048546)2.92026002
103eye photoreceptor cell differentiation (GO:0001754)2.91197703
104photoreceptor cell differentiation (GO:0046530)2.91197703
105flavonoid metabolic process (GO:0009812)2.90909539
106myelination (GO:0042552)2.88968689
107Sertoli cell development (GO:0060009)2.88744269
108DNA damage response, detection of DNA damage (GO:0042769)2.88699427
109membrane protein ectodomain proteolysis (GO:0006509)2.88239356
110axon ensheathment (GO:0008366)2.87346252
111ensheathment of neurons (GO:0007272)2.87346252
112endosome to lysosome transport (GO:0008333)2.86148115
113branching involved in salivary gland morphogenesis (GO:0060445)2.86029847
114polarized epithelial cell differentiation (GO:0030859)2.85367915
115establishment of monopolar cell polarity (GO:0061162)2.85161294
116establishment or maintenance of monopolar cell polarity (GO:0061339)2.85161294
117protein retention in ER lumen (GO:0006621)2.85059465
118regulation of growth hormone secretion (GO:0060123)2.84951129
119axon ensheathment in central nervous system (GO:0032291)2.83211000
120central nervous system myelination (GO:0022010)2.83211000
121regulation of transforming growth factor beta2 production (GO:0032909)2.82531217
122positive regulation of actin filament depolymerization (GO:0030836)2.82510578
123regulation of hydrogen peroxide metabolic process (GO:0010310)2.81784545
124negative regulation of striated muscle cell apoptotic process (GO:0010664)2.81621995
125intestinal epithelial cell development (GO:0060576)2.80349697
126hair cycle (GO:0042633)2.80337297
127molting cycle (GO:0042303)2.80337297
128regulation of catenin import into nucleus (GO:0035412)2.79740466
129apical protein localization (GO:0045176)2.79371619
130mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.79255519
131cell-cell signaling involved in cell fate commitment (GO:0045168)2.78545153
132phenylpropanoid metabolic process (GO:0009698)2.77511250
133negative regulation of glycoprotein biosynthetic process (GO:0010561)2.76427995
134forebrain neuron differentiation (GO:0021879)2.76385548
135postsynaptic membrane organization (GO:0001941)2.76174212
136regulation of posttranscriptional gene silencing (GO:0060147)2.74785842
137regulation of gene silencing by miRNA (GO:0060964)2.74785842
138regulation of gene silencing by RNA (GO:0060966)2.74785842
139neuron fate specification (GO:0048665)2.74033009
140fatty acid elongation (GO:0030497)2.73778577
141ribosomal small subunit biogenesis (GO:0042274)2.73651167
142regulation of cell fate specification (GO:0042659)2.72757572
143hemidesmosome assembly (GO:0031581)2.72587987
144neuron maturation (GO:0042551)2.72510112
145cardiac right ventricle morphogenesis (GO:0003215)2.71748293
146negative regulation of inclusion body assembly (GO:0090084)2.71443085
147transepithelial transport (GO:0070633)2.71286280
148regulation of glycogen metabolic process (GO:0070873)2.70668223
149L-serine transport (GO:0015825)2.70252293
150anterior/posterior axis specification, embryo (GO:0008595)2.70104534
151uronic acid metabolic process (GO:0006063)2.69414776
152glucuronate metabolic process (GO:0019585)2.69414776
153amyloid precursor protein catabolic process (GO:0042987)2.68727567
154gap junction assembly (GO:0016264)2.67851936
155negative regulation of cell fate commitment (GO:0010454)2.67612990
156proximal/distal pattern formation (GO:0009954)2.67512115
157myelination in peripheral nervous system (GO:0022011)2.66780821
158peripheral nervous system axon ensheathment (GO:0032292)2.66780821
159glandular epithelial cell differentiation (GO:0002067)2.66494341
160retina layer formation (GO:0010842)2.65768538
161pyrimidine nucleoside biosynthetic process (GO:0046134)2.65635714
162regulation of axon extension involved in axon guidance (GO:0048841)2.65627891
163columnar/cuboidal epithelial cell development (GO:0002066)2.65138093
164epithelial tube branching involved in lung morphogenesis (GO:0060441)2.65069498
165lung alveolus development (GO:0048286)2.64623619
166molting cycle process (GO:0022404)2.64478183
167hair cycle process (GO:0022405)2.64478183
168regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.63877647
169response to redox state (GO:0051775)2.63590651
170cellular response to vitamin D (GO:0071305)2.63544382
171ventricular septum development (GO:0003281)2.63527596
172positive regulation of protein autophosphorylation (GO:0031954)2.63503055
173mesenchymal cell development (GO:0014031)2.62702701
174paraxial mesoderm development (GO:0048339)2.62474406
175urogenital system development (GO:0001655)2.62348307
176negative regulation of glial cell differentiation (GO:0045686)2.61734353
177neuronal ion channel clustering (GO:0045161)2.61082218
178positive regulation of gastrulation (GO:2000543)2.60811028
179non-canonical Wnt signaling pathway (GO:0035567)2.60184314
180cellular zinc ion homeostasis (GO:0006882)2.59585851
181regulation of protein export from nucleus (GO:0046825)2.59288451
182negative regulation of epidermal cell differentiation (GO:0045605)2.58981961
183negative regulation of axon guidance (GO:1902668)2.58073307
184nonmotile primary cilium assembly (GO:0035058)2.57803187
185otic vesicle formation (GO:0030916)2.57637605
186peptide hormone processing (GO:0016486)2.56994085
187nodal signaling pathway (GO:0038092)2.56968071
188somite rostral/caudal axis specification (GO:0032525)2.56017567
189negative regulation of insulin secretion (GO:0046676)2.54453866
190cranial nerve development (GO:0021545)2.53697546
191water homeostasis (GO:0030104)2.52951241
192regulation of carbohydrate catabolic process (GO:0043470)2.50923806
193regulation of cellular carbohydrate catabolic process (GO:0043471)2.50923806

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.35227514
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.79205647
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.54821829
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.54387096
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.01794430
6SRY_22984422_ChIP-ChIP_TESTIS_Rat2.98300870
7CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.68672007
8WT1_19549856_ChIP-ChIP_CCG9911_Human2.66331553
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.63624961
10CDX2_20551321_ChIP-Seq_CACO-2_Human2.53275086
11EZH2_27294783_Chip-Seq_ESCs_Mouse2.34248852
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.33411427
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31685421
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29937373
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16034490
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15853731
17* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11246339
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.10838489
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07719184
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.07418741
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07258710
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.99070295
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98361026
24* EZH2_27304074_Chip-Seq_ESCs_Mouse1.95413701
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95148711
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95121723
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95121723
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94539889
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92922345
30SOX2_20726797_ChIP-Seq_SW620_Human1.92800436
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.88258371
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86059737
33DROSHA_22980978_ChIP-Seq_HELA_Human1.71947583
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67771528
35EZH2_22144423_ChIP-Seq_EOC_Human1.66808389
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.60765151
37TP53_20018659_ChIP-ChIP_R1E_Mouse1.58627213
38AR_21572438_ChIP-Seq_LNCaP_Human1.52898879
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51956956
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.51886531
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.51417286
42SOX2_27498859_Chip-Seq_STOMACH_Mouse1.50867831
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.50275849
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48637660
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48185766
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.47731246
47KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.47731246
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.47731246
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44202901
50DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44105621
51AHR_22903824_ChIP-Seq_MCF-7_Human1.43374889
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43288300
53HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42592354
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41928763
55* SMAD3_21741376_ChIP-Seq_HESCs_Human1.41889423
56TP53_18474530_ChIP-ChIP_U2OS_Human1.40441356
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40276876
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.40207678
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40176950
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36806535
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.35158251
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34630627
63FUS_26573619_Chip-Seq_HEK293_Human1.33044495
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31677104
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30937666
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29139510
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27099787
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25810370
69* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22340500
70SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22183138
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20192199
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19559296
73OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19424348
74EWS_26573619_Chip-Seq_HEK293_Human1.18958314
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.16412340
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14719131
77TAF15_26573619_Chip-Seq_HEK293_Human1.14405508
78ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12666765
79PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.12646783
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12255920
81* FOXO3_23340844_ChIP-Seq_DLD1_Human1.11564677
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10721068
83SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09558933
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08921740
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08921740
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.08569992
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.07379714
88* CBX2_27304074_Chip-Seq_ESCs_Mouse1.06981273
89LXR_22292898_ChIP-Seq_THP-1_Human1.03917723
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03787208
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.03515431
92AR_21909140_ChIP-Seq_LNCAP_Human1.01724818
93TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01495775
94TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99866555
95* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99011660
96NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98510691
97SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98276727
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97974793
99BCAT_22108803_ChIP-Seq_LS180_Human0.97639491
100GBX2_23144817_ChIP-Seq_PC3_Human0.97463289
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97026265
102ISL1_27105846_Chip-Seq_CPCs_Mouse0.96593609
103RUNX1_27514584_Chip-Seq_MCF-7_Human0.95330106
104ZNF274_21170338_ChIP-Seq_K562_Hela0.95050082
105NANOG_16153702_ChIP-ChIP_HESCs_Human0.94922751
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94908853
107EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94827672
108* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94486991
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94086740
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93980203
111* CTCF_27219007_Chip-Seq_Bcells_Human0.93615932
112* SMAD4_21741376_ChIP-Seq_HESCs_Human0.93145503
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92584321
114* SMAD3_21741376_ChIP-Seq_EPCs_Human0.92335467
115POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.92019586
116* GATA4_25053715_ChIP-Seq_YYC3_Human0.91975276
117* TP63_23658742_ChIP-Seq_EP156T_Human0.91630672
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90556818
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90236435
120STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90121219
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90090373
122FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89895506
123NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89560372
124* RXR_22108803_ChIP-Seq_LS180_Human0.88648518
125TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87736278
126KLF5_25053715_ChIP-Seq_YYC3_Human0.87594769
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87145299
128PIAS1_25552417_ChIP-Seq_VCAP_Human0.86727509
129TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.86280613
130RNF2_27304074_Chip-Seq_NSC_Mouse0.85924780
131PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84705263
132RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.84346177
133NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84236797
134BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.83894944
135SOX2_21211035_ChIP-Seq_LN229_Gbm0.83194880
136* REST_21632747_ChIP-Seq_MESCs_Mouse0.83055961
137TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82187114
138FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79427633
139ESR1_20079471_ChIP-ChIP_T-47D_Human0.77875025
140TCF4_18268006_ChIP-ChIP_LS174T_Human0.77742077
141EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.77656589
142MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.77286077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps5.61780148
2MP0002877_abnormal_melanocyte_morpholog4.30554007
3MP0003941_abnormal_skin_development3.81648645
4MP0001727_abnormal_embryo_implantation3.77422040
5MP0000566_synostosis3.74457674
6MP0003283_abnormal_digestive_organ3.73662366
7MP0000462_abnormal_digestive_system3.58085999
8MP0004264_abnormal_extraembryonic_tissu2.90948752
9MP0002234_abnormal_pharynx_morphology2.68245437
10MP0003119_abnormal_digestive_system2.59609428
11MP0002796_impaired_skin_barrier2.51569040
12MP0000579_abnormal_nail_morphology2.41845474
13MP0005623_abnormal_meninges_morphology2.33127430
14MP0004133_heterotaxia2.32739739
15MP0000537_abnormal_urethra_morphology2.25547672
16MP0004885_abnormal_endolymph2.23023308
17MP0003693_abnormal_embryo_hatching2.16712650
18MP0002909_abnormal_adrenal_gland2.03794486
19MP0009053_abnormal_anal_canal2.00676164
20MP0000762_abnormal_tongue_morphology1.92295124
21MP0009780_abnormal_chondrocyte_physiolo1.91710955
22MP0003315_abnormal_perineum_morphology1.90544142
23MP0002736_abnormal_nociception_after1.87775064
24MP0001485_abnormal_pinna_reflex1.86854067
25MP0004043_abnormal_pH_regulation1.85912148
26MP0000467_abnormal_esophagus_morphology1.82515726
27MP0003937_abnormal_limbs/digits/tail_de1.81517998
28MP0003878_abnormal_ear_physiology1.80890930
29MP0005377_hearing/vestibular/ear_phenot1.80890930
30MP0002098_abnormal_vibrissa_morphology1.77545798
31MP0004272_abnormal_basement_membrane1.76911058
32MP0004134_abnormal_chest_morphology1.76543535
33MP0001293_anophthalmia1.75561295
34MP0001299_abnormal_eye_distance/1.65260056
35MP0000647_abnormal_sebaceous_gland1.63590008
36MP0003453_abnormal_keratinocyte_physiol1.62002213
37MP0009379_abnormal_foot_pigmentation1.56645544
38MP0004742_abnormal_vestibular_system1.55049318
39MP0002295_abnormal_pulmonary_circulatio1.55001233
40MP0002282_abnormal_trachea_morphology1.50514833
41MP0000470_abnormal_stomach_morphology1.49872803
42MP0002277_abnormal_respiratory_mucosa1.49102829
43MP0003755_abnormal_palate_morphology1.48521042
44MP0003191_abnormal_cellular_cholesterol1.48476118
45MP0000678_abnormal_parathyroid_gland1.47557931
46MP0001661_extended_life_span1.47454398
47MP0006072_abnormal_retinal_apoptosis1.47227171
48MP0002249_abnormal_larynx_morphology1.46845350
49MP0001944_abnormal_pancreas_morphology1.43623677
50MP0003136_yellow_coat_color1.42415328
51MP0010030_abnormal_orbit_morphology1.42391058
52MP0000013_abnormal_adipose_tissue1.41441578
53MP0003690_abnormal_glial_cell1.41312297
54MP0005275_abnormal_skin_tensile1.40693737
55MP0002693_abnormal_pancreas_physiology1.38763740
56MP0005171_absent_coat_pigmentation1.38142617
57MP0004957_abnormal_blastocyst_morpholog1.36387227
58MP0005174_abnormal_tail_pigmentation1.34313576
59MP0001286_abnormal_eye_development1.29518987
60MP0001968_abnormal_touch/_nociception1.29352605
61MP0002697_abnormal_eye_size1.28362644
62MP0005248_abnormal_Harderian_gland1.27664336
63MP0003300_gastrointestinal_ulcer1.25986411
64MP0005379_endocrine/exocrine_gland_phen1.25931764
65MP0010386_abnormal_urinary_bladder1.25233620
66MP0002653_abnormal_ependyma_morphology1.23928542
67MP0001984_abnormal_olfaction1.23550199
68MP0003705_abnormal_hypodermis_morpholog1.23340362
69MP0010678_abnormal_skin_adnexa1.23250138
70MP0005501_abnormal_skin_physiology1.22754918
71MP0003137_abnormal_impulse_conducting1.20662961
72MP0005187_abnormal_penis_morphology1.17297363
73MP0000049_abnormal_middle_ear1.16098028
74MP0000534_abnormal_ureter_morphology1.15693087
75MP0002092_abnormal_eye_morphology1.15180260
76MP0000377_abnormal_hair_follicle1.13211348
77MP0000383_abnormal_hair_follicle1.12049485
78MP0004270_analgesia1.11911431
79MP0001346_abnormal_lacrimal_gland1.10411090
80MP0005084_abnormal_gallbladder_morpholo1.08303729
81MP0003806_abnormal_nucleotide_metabolis1.08142687
82MP0005310_abnormal_salivary_gland1.05706048
83MP0001666_abnormal_nutrient_absorption1.04608697
84MP0002837_dystrophic_cardiac_calcinosis1.03852250
85MP0001177_atelectasis1.03840473
86MP0008260_abnormal_autophagy1.02962255
87MP0003567_abnormal_fetal_cardiomyocyte1.02679917
88MP0000427_abnormal_hair_cycle1.02357973
89MP0009250_abnormal_appendicular_skeleto1.02149716
90MP0009384_cardiac_valve_regurgitation1.01557719
91MP0002928_abnormal_bile_duct1.01549346
92MP0000920_abnormal_myelination1.00996453
93MP0003879_abnormal_hair_cell1.00872639
94MP0003566_abnormal_cell_adhesion1.00724573
95MP0001958_emphysema1.00683677
96MP0001849_ear_inflammation0.99184919
97MP0003935_abnormal_craniofacial_develop0.99069381
98MP0005381_digestive/alimentary_phenotyp0.98838204
99MP0000778_abnormal_nervous_system0.97810713
100MP0004185_abnormal_adipocyte_glucose0.96557996
101MP0005220_abnormal_exocrine_pancreas0.94662618
102MP0005076_abnormal_cell_differentiation0.94494479
103MP0002638_abnormal_pupillary_reflex0.93444479
104MP0004782_abnormal_surfactant_physiolog0.93376786
105MP0002896_abnormal_bone_mineralization0.92577497
106MP0002938_white_spotting0.89733970
107MP0000631_abnormal_neuroendocrine_gland0.89581052
108MP0000428_abnormal_craniofacial_morphol0.89091340
109MP0004858_abnormal_nervous_system0.88641739
110MP0002084_abnormal_developmental_patter0.88200737
111MP0005499_abnormal_olfactory_system0.87560172
112MP0005394_taste/olfaction_phenotype0.87560172
113MP0005508_abnormal_skeleton_morphology0.86907041
114MP0002060_abnormal_skin_morphology0.86136876
115MP0001340_abnormal_eyelid_morphology0.85724250
116MP0000163_abnormal_cartilage_morphology0.85623645
117MP0005409_darkened_coat_color0.85002110
118MP0003221_abnormal_cardiomyocyte_apopto0.84356722
119MP0003942_abnormal_urinary_system0.84305760
120MP0000432_abnormal_head_morphology0.83750274
121MP0003861_abnormal_nervous_system0.83665537
122MP0000538_abnormal_urinary_bladder0.82797451
123MP0010234_abnormal_vibrissa_follicle0.81705501
124MP0002109_abnormal_limb_morphology0.81569344
125MP0008789_abnormal_olfactory_epithelium0.80895273
126MP0002233_abnormal_nose_morphology0.80387418
127MP0003115_abnormal_respiratory_system0.79817332
128MP0002116_abnormal_craniofacial_bone0.78681825
129MP0000026_abnormal_inner_ear0.78371542
130MP0003938_abnormal_ear_development0.77419359
131MP0008932_abnormal_embryonic_tissue0.76156582
132MP0001529_abnormal_vocalization0.74685694
133MP0001216_abnormal_epidermal_layer0.74683986
134MP0003890_abnormal_embryonic-extraembry0.73996425
135MP0000613_abnormal_salivary_gland0.73705619
136MP0005085_abnormal_gallbladder_physiolo0.73069547
137MP0001765_abnormal_ion_homeostasis0.72610509
138MP0001784_abnormal_fluid_regulation0.72287873
139MP0002111_abnormal_tail_morphology0.72091663
140MP0003943_abnormal_hepatobiliary_system0.72035339
141MP0005257_abnormal_intraocular_pressure0.70763437
142MP0000477_abnormal_intestine_morphology0.69601286
143MP0003195_calcinosis0.69275058
144MP0002009_preneoplasia0.69221692
145MP0009643_abnormal_urine_homeostasis0.68887768
146MP0001188_hyperpigmentation0.68465131
147MP0003385_abnormal_body_wall0.68348427
148MP0003634_abnormal_glial_cell0.67873489
149MP0002085_abnormal_embryonic_tissue0.67813368
150MP0005367_renal/urinary_system_phenotyp0.67237691
151MP0000516_abnormal_urinary_system0.67237691
152MP0005391_vision/eye_phenotype0.66703343
153MP0002932_abnormal_joint_morphology0.65919194
154MP0001963_abnormal_hearing_physiology0.63882450
155MP0002078_abnormal_glucose_homeostasis0.62811879
156MP0004381_abnormal_hair_follicle0.62010718
157MP0003252_abnormal_bile_duct0.61729939
158MP0010771_integument_phenotype0.60483924
159MP0003866_abnormal_defecation0.60476544

Predicted human phenotypes

RankGene SetZ-score
1Unilateral renal agenesis (HP:0000122)6.57079293
2Multiple enchondromatosis (HP:0005701)5.92689371
3Atrioventricular block (HP:0001678)5.16228368
4Abnormal ciliary motility (HP:0012262)3.69801438
5Aplasia cutis congenita (HP:0001057)3.64062790
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.63961318
7Decreased circulating renin level (HP:0003351)3.59116720
8Abnormal respiratory motile cilium physiology (HP:0012261)3.54783882
9Symptomatic seizures (HP:0011145)3.54250524
10Septo-optic dysplasia (HP:0100842)3.52636016
11Atrophic scars (HP:0001075)3.50789297
12Esophageal atresia (HP:0002032)3.48303311
13Abnormal respiratory motile cilium morphology (HP:0005938)3.46924571
14Abnormal respiratory epithelium morphology (HP:0012253)3.46924571
15Heart block (HP:0012722)3.45137178
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.43358708
17Coronal craniosynostosis (HP:0004440)3.39126713
18Abnormal hemoglobin (HP:0011902)3.36066612
19Missing ribs (HP:0000921)3.32515790
20Hypoplastic labia majora (HP:0000059)3.30771003
21Abnormal atrioventricular conduction (HP:0005150)3.27150637
22Abnormal cartilage morphology (HP:0002763)3.20501089
23Abnormality of the labia majora (HP:0012881)3.17060426
24Rhinitis (HP:0012384)3.15696010
25Milia (HP:0001056)3.10011375
26Abnormality of the parathyroid morphology (HP:0011766)3.08055246
27Abnormality of the parietal bone (HP:0002696)3.02842238
28Congenital ichthyosiform erythroderma (HP:0007431)3.02810576
29Dynein arm defect of respiratory motile cilia (HP:0012255)3.01411598
30Absent/shortened dynein arms (HP:0200106)3.01411598
31Fragile nails (HP:0001808)3.01251330
32Hyperinsulinemic hypoglycemia (HP:0000825)2.99323235
33Delayed epiphyseal ossification (HP:0002663)2.96292922
34Abnormality of renin-angiotensin system (HP:0000847)2.90510281
35Metabolic alkalosis (HP:0200114)2.90214989
36Split foot (HP:0001839)2.88994656
37Abnormality of calcium-phosphate metabolism (HP:0100530)2.85039482
38True hermaphroditism (HP:0010459)2.82379632
39Partial duplication of thumb phalanx (HP:0009944)2.79439799
40Male infertility (HP:0003251)2.77957103
41Malnutrition (HP:0004395)2.76430603
42Abnormality of the intrinsic pathway (HP:0010989)2.75583634
43Ventricular fibrillation (HP:0001663)2.75481942
44Corneal erosion (HP:0200020)2.75283794
45Thick nail (HP:0001805)2.74914846
46Down-sloping shoulders (HP:0200021)2.74851532
47Bronchomalacia (HP:0002780)2.69970610
48Hypoglycemic coma (HP:0001325)2.64378453
49Labial hypoplasia (HP:0000066)2.64330972
50Bifid scrotum (HP:0000048)2.62900398
51Abnormal auditory evoked potentials (HP:0006958)2.61834895
52Pterygium (HP:0001059)2.59449351
53Cortical visual impairment (HP:0100704)2.56616936
54Bundle branch block (HP:0011710)2.55759254
55Flat capital femoral epiphysis (HP:0003370)2.52044619
56Congenital malformation of the right heart (HP:0011723)2.50940956
57Double outlet right ventricle (HP:0001719)2.50940956
58Hypokalemia (HP:0002900)2.50857507
59Hypoglycemic seizures (HP:0002173)2.50629383
60Abnormality of secondary sexual hair (HP:0009888)2.50591745
61Abnormality of the axillary hair (HP:0100134)2.50591745
62Pili torti (HP:0003777)2.48045737
63Reticulocytopenia (HP:0001896)2.47300641
64Chin dimple (HP:0010751)2.46371410
65Sex reversal (HP:0012245)2.45725728
66Abnormal sex determination (HP:0012244)2.45725728
67Hypoplastic female external genitalia (HP:0012815)2.44778755
68Abnormality of aromatic amino acid family metabolism (HP:0004338)2.44672551
69Palmar hyperkeratosis (HP:0010765)2.44599857
70Palmoplantar hyperkeratosis (HP:0000972)2.41061152
71Partial duplication of the phalanx of hand (HP:0009999)2.40754865
72Achilles tendon contracture (HP:0001771)2.39386158
73Rib fusion (HP:0000902)2.39050997
74Abnormality of the lacrimal duct (HP:0011481)2.38333093
75Abnormality of nail color (HP:0100643)2.38262841
76Oligodactyly (HP:0012165)2.37205876
77Small epiphyses (HP:0010585)2.37045615
78Nasolacrimal duct obstruction (HP:0000579)2.30856768
79Sensory axonal neuropathy (HP:0003390)2.28665094
80Aplasia of the phalanges of the hand (HP:0009802)2.28110430
81Aplasia involving bones of the extremities (HP:0009825)2.28110430
82Aplasia involving bones of the upper limbs (HP:0009823)2.28110430
83Pancreatic fibrosis (HP:0100732)2.24630097
84Woolly hair (HP:0002224)2.24306106
85Alopecia of scalp (HP:0002293)2.24182159
86Irregular vertebral endplates (HP:0003301)2.24055386
87Morphological abnormality of the inner ear (HP:0011390)2.23646322
88Midline defect of the nose (HP:0004122)2.22892383
89Ketoacidosis (HP:0001993)2.22458579
90Amelogenesis imperfecta (HP:0000705)2.21661433
91Popliteal pterygium (HP:0009756)2.21095970
92Mixed hearing impairment (HP:0000410)2.20757308
93Anophthalmia (HP:0000528)2.19302126
94Nail dystrophy (HP:0008404)2.18620893
95Selective tooth agenesis (HP:0001592)2.18205855
96Premature skin wrinkling (HP:0100678)2.16616123
97Attenuation of retinal blood vessels (HP:0007843)2.16204219
98Follicular hyperkeratosis (HP:0007502)2.16187394
99Abnormality of the Achilles tendon (HP:0005109)2.16065035
100Exostoses (HP:0100777)2.15768562
101Myelomeningocele (HP:0002475)2.15699410
102Scapular winging (HP:0003691)2.15284440
103Parakeratosis (HP:0001036)2.11510182
104Oligodactyly (hands) (HP:0001180)2.07698747
105Preaxial foot polydactyly (HP:0001841)2.07076704
106Cupped ear (HP:0000378)2.05526102
107Abnormality of permanent molar morphology (HP:0011071)2.05328881
108Abnormality of the dental root (HP:0006486)2.05328881
109Taurodontia (HP:0000679)2.05328881
110Spinal cord compression (HP:0002176)2.05017296
111Abnormality of the dental pulp (HP:0006479)2.04096983
112Hyperactive renin-angiotensin system (HP:0000841)2.03925980
113Abnormality of midbrain morphology (HP:0002418)2.03173135
114Molar tooth sign on MRI (HP:0002419)2.03173135
115Hypokalemic alkalosis (HP:0001949)2.02253722
116Depressed nasal tip (HP:0000437)2.02070191
117Abnormality of the nasolacrimal system (HP:0000614)2.01963953
118Chronic bronchitis (HP:0004469)2.01957946
119Right ventricular cardiomyopathy (HP:0011663)2.01123344
120Tubular atrophy (HP:0000092)2.01035624
121Increased circulating renin level (HP:0000848)1.99703821
122Abnormality of the middle phalanges of the toes (HP:0010183)1.99639449
123Hypotrichosis (HP:0001006)1.99317613
124Abnormality of magnesium homeostasis (HP:0004921)1.98074647
125Bilateral microphthalmos (HP:0007633)1.96666450
126Focal segmental glomerulosclerosis (HP:0000097)1.96630622
127Sparse eyelashes (HP:0000653)1.96343270
128Maternal diabetes (HP:0009800)1.94982850
129Pancreatic cysts (HP:0001737)1.91439350
130Rectal fistula (HP:0100590)1.91346041
131Rectovaginal fistula (HP:0000143)1.91346041
132Morphological abnormality of the middle ear (HP:0008609)1.91011568
133Abnormality of the salivary glands (HP:0010286)1.90136269
134Bony spicule pigmentary retinopathy (HP:0007737)1.89793716
135Abdominal distention (HP:0003270)1.89300101
136Renal agenesis (HP:0000104)1.89041861
137Absent hair (HP:0002298)1.88874439
138Epiphyseal dysplasia (HP:0002656)1.88524933
139Nephronophthisis (HP:0000090)1.88337026
140Congenital, generalized hypertrichosis (HP:0004540)1.87414358
141Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.87234128
142Abnormality of the vitreous humor (HP:0004327)1.86829928
143Erythroderma (HP:0001019)1.86425895
144Hyperparathyroidism (HP:0000843)1.86199431
145Onycholysis (HP:0001806)1.84813471
146Gastrointestinal atresia (HP:0002589)1.83886952
147Subaortic stenosis (HP:0001682)1.82013581
148Abnormality of the left ventricular outflow tract (HP:0011103)1.82013581
149Hyperextensible skin (HP:0000974)1.81749262
150Abnormal hair laboratory examination (HP:0003328)1.81664309
151Absent eyebrow (HP:0002223)1.81396413
152Hemorrhage of the eye (HP:0011885)1.80960598
153Abnormality of molar (HP:0011077)1.80701057
154Abnormality of molar morphology (HP:0011070)1.80701057
155Hypomagnesemia (HP:0002917)1.79860757
156Abnormality of the labia (HP:0000058)1.79695867
157Sclerocornea (HP:0000647)1.78799304
158Abnormality of cochlea (HP:0000375)1.78775596
159Aplasia/hypoplasia of the uterus (HP:0008684)1.78717850
160Abnormal vertebral ossification (HP:0100569)1.78373314
161Aqueductal stenosis (HP:0002410)1.77512338
162Absent septum pellucidum (HP:0001331)1.76829659
163Hypoplastic nipples (HP:0002557)1.76562081
164Optic nerve hypoplasia (HP:0000609)1.76174972
165Amniotic constriction ring (HP:0009775)1.75650443
166Abnormality of placental membranes (HP:0011409)1.75650443
167Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.75016085
168Vertebral hypoplasia (HP:0008417)1.75016085
169Absent eyelashes (HP:0000561)1.74565132
170Intestinal atresia (HP:0011100)1.73519920
171Hypoplasia of the uterus (HP:0000013)1.70652998
172Insulin-resistant diabetes mellitus (HP:0000831)1.70427975
173Hypoplasia of dental enamel (HP:0006297)1.70159853
174Nonprogressive disorder (HP:0003680)1.69352078
175Protuberant abdomen (HP:0001538)1.68996825
176Plantar hyperkeratosis (HP:0007556)1.67939263
177Ankyloglossia (HP:0010296)1.67558437
178Deep palmar crease (HP:0006191)1.66880738
179Glomerulosclerosis (HP:0000096)1.65631000
180Abnormality of potassium homeostasis (HP:0011042)1.65132663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK5.20729745
2TSSK64.15853483
3TAOK33.82968299
4TNIK3.72979197
5MAP3K23.67258897
6WEE13.46163742
7EPHA22.87674014
8BMPR1B2.75365804
9IRAK22.68053791
10PDGFRA2.64268937
11TGFBR12.63401963
12IRAK12.54082361
13STK392.50675057
14MAPK152.50221827
15PBK2.48558080
16PASK2.29063913
17TYRO32.25425299
18LATS22.14025126
19PRKCH2.13836355
20EPHB12.12895312
21CAMK1D2.07248362
22MKNK22.07174712
23INSRR1.98404075
24ABL21.97979114
25CDK81.97786341
26ACVR1B1.90175710
27OXSR11.86405536
28NTRK11.78917442
29PKN11.75663087
30WNK41.71068826
31LATS11.66438645
32MAP2K21.65898937
33IRAK41.55493991
34SIK11.53573008
35CAMK1G1.50575826
36NME11.50546936
37UHMK11.47185794
38ALK1.46429122
39HIPK21.46048902
40BCR1.38316190
41STK38L1.30033607
42KSR21.27982568
43PRKD31.27113468
44PLK41.24674375
45MAP3K11.24590371
46TIE11.23665491
47MKNK11.23241370
48PDGFRB1.19215056
49MET1.19010893
50PAK31.18341707
51BRSK21.14602601
52SCYL21.13530452
53FER1.08662519
54EPHA31.07981869
55MARK21.05328906
56ADRBK11.04351752
57MAPKAPK30.97145177
58JAK10.97026495
59ROCK10.96145447
60CAMKK20.95696832
61MST40.95622697
62NEK10.95278071
63ERBB20.91000680
64MAPK130.85809307
65TESK10.84777453
66PIM20.84757317
67PAK40.84311398
68PRKCE0.79830883
69DMPK0.78342578
70PTK60.78028820
71FES0.77584533
72NTRK30.77472186
73FGFR10.76477311
74STK30.75331428
75MST1R0.74810913
76DDR20.74427977
77PRKD20.73698372
78TTK0.72526154
79MAP3K80.72008151
80PTK20.70931844
81CASK0.68955671
82JAK20.67910676
83GSK3A0.67564823
84PRKACA0.65188410
85ICK0.65113250
86WNK30.65025926
87RPS6KA20.64953280
88DYRK30.63375562
89TAF10.60817960
90STK240.60561103
91CDK30.60186855
92CSNK1A10.60016047
93CDC42BPA0.59689546
94MAP2K10.59156525
95DYRK20.58483554
96PTK2B0.57739846
97PIK3CA0.56480062
98MAPKAPK50.56426293
99EPHB20.56381927
100ERBB40.55717071
101STK100.53908943
102MELK0.53769955
103VRK20.53063647
104NTRK20.52343653
105MAP3K60.52201902
106RPS6KB20.51984876
107PLK30.51441663
108DYRK1B0.49896655
109TRIB30.49824442
110ROCK20.49757739
111CSNK1A1L0.49445490
112PRKCI0.49436338
113PHKG10.49199518
114PHKG20.49199518
115CAMK2D0.47959310
116CHEK20.47827690
117PRKCA0.45167564
118BUB10.45165156
119TYK20.44919954
120SRC0.44333569
121PDPK10.43863864
122CAMK2G0.42129742
123FGFR40.41672611
124EPHA40.41621995
125CAMK2B0.40973124
126IRAK30.39909834
127MAP3K110.39786940
128PRKACG0.39770414
129CSNK1G30.39497701
130VRK10.39382383
131RET0.39151732
132ARAF0.38804480
133FYN0.38325208
134RPS6KA10.37878145
135PRKD10.37276437
136LMTK20.37252308
137CSK0.36639192
138NUAK10.36467862
139BCKDK0.36000319
140PRKG20.34599248
141LRRK20.34121205
142NEK60.33604187
143MAP2K40.32811855
144MAP2K70.32290989
145MAPK140.31012090
146EIF2AK20.29816858
147GSK3B0.29760493
148CDK70.29677253
149SGK2230.29573225
150SGK4940.29573225
151MTOR0.29167709
152PKN20.26774886
153GRK10.26755205
154PLK10.25936884
155CDK120.25871604
156PAK20.25442945
157PRKCG0.24271516
158CHUK0.21963414
159MUSK0.21824428

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.12171740
2Drug metabolism - other enzymes_Homo sapiens_hsa009833.77906025
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.56498091
4Sulfur metabolism_Homo sapiens_hsa009203.46754882
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.07619066
6Protein export_Homo sapiens_hsa030602.38941963
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.14428549
8Oxidative phosphorylation_Homo sapiens_hsa001902.13043995
9Fatty acid elongation_Homo sapiens_hsa000622.02286158
10Alzheimers disease_Homo sapiens_hsa050101.94411170
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.93119901
12Sphingolipid metabolism_Homo sapiens_hsa006001.89134531
13Vitamin digestion and absorption_Homo sapiens_hsa049771.86868352
14TGF-beta signaling pathway_Homo sapiens_hsa043501.78842018
15RNA polymerase_Homo sapiens_hsa030201.76588539
16Type II diabetes mellitus_Homo sapiens_hsa049301.75317459
17Nitrogen metabolism_Homo sapiens_hsa009101.73328232
18Vibrio cholerae infection_Homo sapiens_hsa051101.66478242
19Insulin resistance_Homo sapiens_hsa049311.66064015
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.65985349
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65961074
22Protein digestion and absorption_Homo sapiens_hsa049741.65102832
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.64171651
24Sulfur relay system_Homo sapiens_hsa041221.60143733
25Butanoate metabolism_Homo sapiens_hsa006501.58715621
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.56055515
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55181552
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.54450568
29Wnt signaling pathway_Homo sapiens_hsa043101.48451223
30ECM-receptor interaction_Homo sapiens_hsa045121.42746212
31Adherens junction_Homo sapiens_hsa045201.39712021
32N-Glycan biosynthesis_Homo sapiens_hsa005101.38956057
33Insulin secretion_Homo sapiens_hsa049111.36906841
34Glutathione metabolism_Homo sapiens_hsa004801.32496568
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30336760
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.29997449
37Ribosome_Homo sapiens_hsa030101.22662809
38Small cell lung cancer_Homo sapiens_hsa052221.19694887
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19407200
40Axon guidance_Homo sapiens_hsa043601.19047774
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12650652
42MicroRNAs in cancer_Homo sapiens_hsa052061.10639850
43Parkinsons disease_Homo sapiens_hsa050121.10408272
44Collecting duct acid secretion_Homo sapiens_hsa049661.04598263
45Prion diseases_Homo sapiens_hsa050201.03974697
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03902929
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03558060
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03257071
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02254391
50Steroid biosynthesis_Homo sapiens_hsa001001.00678429
51Pathways in cancer_Homo sapiens_hsa052001.00109105
52Tight junction_Homo sapiens_hsa045300.99831813
53Basal cell carcinoma_Homo sapiens_hsa052170.99529960
54Ether lipid metabolism_Homo sapiens_hsa005650.96651674
55Folate biosynthesis_Homo sapiens_hsa007900.95764643
56Fatty acid metabolism_Homo sapiens_hsa012120.93411291
57ABC transporters_Homo sapiens_hsa020100.93380922
58Starch and sucrose metabolism_Homo sapiens_hsa005000.92779625
59Salivary secretion_Homo sapiens_hsa049700.90843416
60Fatty acid degradation_Homo sapiens_hsa000710.90334157
61Fanconi anemia pathway_Homo sapiens_hsa034600.88384717
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86514084
63Caffeine metabolism_Homo sapiens_hsa002320.86461314
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85296117
65Pancreatic secretion_Homo sapiens_hsa049720.84632241
66Tryptophan metabolism_Homo sapiens_hsa003800.84166599
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83990729
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81520624
69Mineral absorption_Homo sapiens_hsa049780.81199501
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.80788220
71Histidine metabolism_Homo sapiens_hsa003400.80691507
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80068346
73Thyroid hormone synthesis_Homo sapiens_hsa049180.79663604
74Notch signaling pathway_Homo sapiens_hsa043300.77815604
75Pyruvate metabolism_Homo sapiens_hsa006200.74429985
76Cholinergic synapse_Homo sapiens_hsa047250.74026456
77Melanoma_Homo sapiens_hsa052180.72429735
78Type I diabetes mellitus_Homo sapiens_hsa049400.71537978
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71529268
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70722837
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70539535
82beta-Alanine metabolism_Homo sapiens_hsa004100.70323328
83Phototransduction_Homo sapiens_hsa047440.69881375
84PPAR signaling pathway_Homo sapiens_hsa033200.69815262
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.69243106
86RNA degradation_Homo sapiens_hsa030180.68569745
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68406553
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68319966
89Bile secretion_Homo sapiens_hsa049760.68050830
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67834088
91Nicotine addiction_Homo sapiens_hsa050330.67672202
92Taste transduction_Homo sapiens_hsa047420.66270621
93Dilated cardiomyopathy_Homo sapiens_hsa054140.66119086
94Huntingtons disease_Homo sapiens_hsa050160.65431324
95Long-term potentiation_Homo sapiens_hsa047200.65310093
96Insulin signaling pathway_Homo sapiens_hsa049100.63915615
97Serotonergic synapse_Homo sapiens_hsa047260.63745812
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63014880
99Focal adhesion_Homo sapiens_hsa045100.62109518
100Cocaine addiction_Homo sapiens_hsa050300.60391768
101Dorso-ventral axis formation_Homo sapiens_hsa043200.60113187
102Glycerolipid metabolism_Homo sapiens_hsa005610.59821897
103cAMP signaling pathway_Homo sapiens_hsa040240.58887215
104Rheumatoid arthritis_Homo sapiens_hsa053230.58877354
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57402560
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.56749596
107Homologous recombination_Homo sapiens_hsa034400.56573508
108Melanogenesis_Homo sapiens_hsa049160.56109544
109Cell cycle_Homo sapiens_hsa041100.55578386
110Viral myocarditis_Homo sapiens_hsa054160.54979256
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54312941
112Basal transcription factors_Homo sapiens_hsa030220.51996497
113Chemical carcinogenesis_Homo sapiens_hsa052040.51679604
114GABAergic synapse_Homo sapiens_hsa047270.51344941
115Hedgehog signaling pathway_Homo sapiens_hsa043400.50791307
116Bladder cancer_Homo sapiens_hsa052190.49902233
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48912647
118Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48536467
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48108047
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47196503
121Alcoholism_Homo sapiens_hsa050340.46972871
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46649964
123Ovarian steroidogenesis_Homo sapiens_hsa049130.45809640
124p53 signaling pathway_Homo sapiens_hsa041150.45215942
125Prostate cancer_Homo sapiens_hsa052150.44859065
126Amoebiasis_Homo sapiens_hsa051460.42685981
127Glutamatergic synapse_Homo sapiens_hsa047240.42103726
128Colorectal cancer_Homo sapiens_hsa052100.41085027
129Amphetamine addiction_Homo sapiens_hsa050310.38427415
130Linoleic acid metabolism_Homo sapiens_hsa005910.38391897
131Renal cell carcinoma_Homo sapiens_hsa052110.38184435
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.37125388
133Estrogen signaling pathway_Homo sapiens_hsa049150.37016787
134Cardiac muscle contraction_Homo sapiens_hsa042600.36558007
135Selenocompound metabolism_Homo sapiens_hsa004500.36540450
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36381219
137Phenylalanine metabolism_Homo sapiens_hsa003600.35795927
138Tyrosine metabolism_Homo sapiens_hsa003500.35324192
139Circadian entrainment_Homo sapiens_hsa047130.33970363
140Fatty acid biosynthesis_Homo sapiens_hsa000610.33437222
141Gastric acid secretion_Homo sapiens_hsa049710.33419661
142Dopaminergic synapse_Homo sapiens_hsa047280.32469922
143Retinol metabolism_Homo sapiens_hsa008300.31947304
144Proteoglycans in cancer_Homo sapiens_hsa052050.27826479
145Hippo signaling pathway_Homo sapiens_hsa043900.27254936
146Fructose and mannose metabolism_Homo sapiens_hsa000510.26780339
147Arginine and proline metabolism_Homo sapiens_hsa003300.24495916

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »