RASSF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.83623232
2positive regulation of gamma-delta T cell activation (GO:0046645)5.15428709
3detection of molecule of bacterial origin (GO:0032490)4.94975339
4detection of other organism (GO:0098543)4.87108204
5antigen processing and presentation of endogenous antigen (GO:0019883)4.68202881
6positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.55917628
7detection of external biotic stimulus (GO:0098581)4.45616724
8regulation of B cell receptor signaling pathway (GO:0050855)4.44637884
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.38851093
10negative regulation of cell killing (GO:0031342)4.38851093
11detection of bacterium (GO:0016045)4.37736031
12negative thymic T cell selection (GO:0045060)4.29550935
13negative regulation of interleukin-12 production (GO:0032695)4.29219709
14negative T cell selection (GO:0043383)4.25533137
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.17522185
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.17522185
17negative regulation of lymphocyte mediated immunity (GO:0002707)4.11882438
18response to host immune response (GO:0052572)4.10787779
19response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.10787779
20macrophage activation (GO:0042116)4.02451821
21detection of biotic stimulus (GO:0009595)3.94455330
22B cell receptor signaling pathway (GO:0050853)3.94453897
23negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.82963197
24leukocyte aggregation (GO:0070486)3.77145961
25neutrophil activation (GO:0042119)3.75809574
26NIK/NF-kappaB signaling (GO:0038061)3.75692345
27positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.75589503
28response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.75065418
29response to host (GO:0075136)3.75065418
30response to host defenses (GO:0052200)3.75065418
31positive regulation of mast cell activation (GO:0033005)3.73676313
32positive regulation of antigen processing and presentation (GO:0002579)3.71747377
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.71247092
34negative regulation of T cell mediated immunity (GO:0002710)3.69228637
35regulation of mast cell degranulation (GO:0043304)3.68331022
36positive regulation of B cell differentiation (GO:0045579)3.68066554
37leukocyte migration involved in inflammatory response (GO:0002523)3.66993279
38negative regulation of leukocyte mediated immunity (GO:0002704)3.66888339
39neutrophil activation involved in immune response (GO:0002283)3.66862794
40regulation of B cell differentiation (GO:0045577)3.58710436
41regulation of interferon-beta biosynthetic process (GO:0045357)3.57050474
42regulation of gamma-delta T cell differentiation (GO:0045586)3.50225531
43T cell migration (GO:0072678)3.48690781
44positive thymic T cell selection (GO:0045059)3.47876615
45regulation of interleukin-12 biosynthetic process (GO:0045075)3.46263189
46myeloid leukocyte mediated immunity (GO:0002444)3.43814686
47regulation of mast cell activation involved in immune response (GO:0033006)3.43740303
48regulation of myeloid leukocyte mediated immunity (GO:0002886)3.42956270
49mast cell activation (GO:0045576)3.40613059
50regulation of mast cell activation (GO:0033003)3.40432889
51modulation by symbiont of host immune response (GO:0052553)3.40391001
52positive regulation by symbiont of host defense response (GO:0052509)3.40391001
53modulation by symbiont of host defense response (GO:0052031)3.40391001
54modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.40391001
55modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.40391001
56positive regulation by organism of defense response of other organism involved in symbiotic interact3.40391001
57thymic T cell selection (GO:0045061)3.40154377
58granulocyte activation (GO:0036230)3.39768457
59regulation of dendritic cell antigen processing and presentation (GO:0002604)3.39387822
60regulation of gamma-delta T cell activation (GO:0046643)3.38996229
61T cell selection (GO:0045058)3.38485449
62regulation of T cell tolerance induction (GO:0002664)3.33455257
63production of molecular mediator involved in inflammatory response (GO:0002532)3.33389899
64regulation of leukocyte degranulation (GO:0043300)3.33262504
65negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.30859494
66positive regulation of cellular amide metabolic process (GO:0034250)3.29244646
67positive regulation of mast cell activation involved in immune response (GO:0033008)3.28711191
68positive regulation of mast cell degranulation (GO:0043306)3.28711191
69myeloid dendritic cell activation (GO:0001773)3.24936142
70response to interleukin-15 (GO:0070672)3.23840430
71cellular response to interleukin-15 (GO:0071350)3.19760410
72mature B cell differentiation (GO:0002335)3.16522441
73macrophage activation involved in immune response (GO:0002281)3.15419403
74antigen processing and presentation via MHC class Ib (GO:0002475)3.13900322
75negative regulation of erythrocyte differentiation (GO:0045647)3.13116777
76regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.11259926
77myeloid cell activation involved in immune response (GO:0002275)3.10324468
78regulation of antigen processing and presentation (GO:0002577)3.08622707
79myeloid dendritic cell differentiation (GO:0043011)3.08412229
80positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.07477789
81positive T cell selection (GO:0043368)3.06515868
82germinal center formation (GO:0002467)3.04227899
83cellular extravasation (GO:0045123)3.03111214
84regulation of regulated secretory pathway (GO:1903305)3.00818890
85regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.00232484
86regulation of macrophage cytokine production (GO:0010935)2.99425177
87response to muramyl dipeptide (GO:0032495)2.98674054
88regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.97587100
89interferon-gamma-mediated signaling pathway (GO:0060333)2.95040973
90B cell homeostasis (GO:0001782)2.94952629
91antigen receptor-mediated signaling pathway (GO:0050851)2.93387427
92mast cell activation involved in immune response (GO:0002279)2.93133757
93mast cell degranulation (GO:0043303)2.93133757
94regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.92051032
95negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.90054982
96microglial cell activation (GO:0001774)2.89985250
97negative regulation of type 2 immune response (GO:0002829)2.88252905
98response to peptidoglycan (GO:0032494)2.88200667
99positive regulation of macrophage cytokine production (GO:0060907)2.88065369
100respiratory burst (GO:0045730)2.85198777
101myeloid leukocyte activation (GO:0002274)2.84140568
102lipopolysaccharide-mediated signaling pathway (GO:0031663)2.83940154
103neutrophil chemotaxis (GO:0030593)2.82492451
104negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.82030295
105negative regulation of T-helper cell differentiation (GO:0045623)2.82030295
106regulation of T-helper 2 cell differentiation (GO:0045628)2.81871893
107tolerance induction (GO:0002507)2.81846668
108positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.81751507
109negative regulation of granulocyte differentiation (GO:0030853)2.81516405
110immunoglobulin mediated immune response (GO:0016064)2.80969738
111positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.76215663
112positive regulation of interleukin-2 production (GO:0032743)2.75595341
113negative regulation of phagocytosis (GO:0050765)2.75216886
114activated T cell proliferation (GO:0050798)2.74773834
115dendritic cell chemotaxis (GO:0002407)2.74228335
116T cell costimulation (GO:0031295)2.73576027
117interferon-gamma production (GO:0032609)2.71832816
118regulation of tolerance induction (GO:0002643)2.71119716
119regulation of alpha-beta T cell proliferation (GO:0046640)2.70761265
120dendritic cell differentiation (GO:0097028)2.69868011
121lymphocyte homeostasis (GO:0002260)2.69865242
122dendritic cell migration (GO:0036336)2.69570243
123lymphocyte costimulation (GO:0031294)2.68852691
124growth hormone receptor signaling pathway (GO:0060396)2.67351559
125positive regulation of interferon-alpha production (GO:0032727)2.66513213
126regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.65551546
127negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.65482752
128megakaryocyte development (GO:0035855)2.64806423
129JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.64195466
130response to type I interferon (GO:0034340)2.62334786
131T cell receptor signaling pathway (GO:0050852)2.61390979
132regulation of interleukin-2 biosynthetic process (GO:0045076)2.60935119
133cellular response to zinc ion (GO:0071294)2.60678839
134type I interferon signaling pathway (GO:0060337)2.59948960
135cellular response to type I interferon (GO:0071357)2.59948960
136positive regulation of chemokine secretion (GO:0090197)2.59212740
137leukocyte degranulation (GO:0043299)2.58488725
138neutrophil mediated immunity (GO:0002446)2.58248695
139defense response to protozoan (GO:0042832)2.57925651
140natural killer cell differentiation (GO:0001779)2.57557669
141T cell homeostasis (GO:0043029)2.54261678
142immune response-activating cell surface receptor signaling pathway (GO:0002429)2.52801504
143positive regulation of natural killer cell differentiation (GO:0032825)2.52723655
144natural killer cell activation (GO:0030101)2.52370173
145hepatocyte apoptotic process (GO:0097284)2.51239017
146regulation of interferon-alpha production (GO:0032647)2.50959363
147positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.50110190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.53841083
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.85925465
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.67282719
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.41809534
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.48607702
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.45937590
7RUNX_20019798_ChIP-Seq_JUKART_Human3.36614215
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.32814157
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.25133017
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.18373390
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.13637341
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.91230637
13SCL_19346495_ChIP-Seq_HPC-7_Human2.81860831
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.69300401
15* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.66885911
16* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64717560
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.42041504
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.31355281
19MYB_26560356_Chip-Seq_TH2_Human2.21577939
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.16428080
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.15460319
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.13830661
23VDR_21846776_ChIP-Seq_THP-1_Human2.06308078
24SPI1_23127762_ChIP-Seq_K562_Human2.05558180
25MAF_26560356_Chip-Seq_TH1_Human1.99983378
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93068583
27VDR_24763502_ChIP-Seq_THP-1_Human1.92415617
28MYB_26560356_Chip-Seq_TH1_Human1.83597493
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80260479
30* MYC_22102868_ChIP-Seq_BL_Human1.75271500
31VDR_24787735_ChIP-Seq_THP-1_Human1.74978806
32* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70870946
33NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.70002253
34* SPI1_23547873_ChIP-Seq_NB4_Human1.68199721
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67181202
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65361877
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64590878
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62972361
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.62385653
40* TCF7_22412390_ChIP-Seq_EML_Mouse1.62096735
41* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61283191
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58370935
43* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57990047
44UTX_26944678_Chip-Seq_JUKART_Human1.57232529
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.55743648
46* KDM2B_26808549_Chip-Seq_DND41_Human1.51134252
47PU_27001747_Chip-Seq_BMDM_Mouse1.50197607
48* GATA3_27048872_Chip-Seq_THYMUS_Human1.46948737
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45376383
50* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38317912
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32751382
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31575249
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30500611
54* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25508055
55GATA1_22025678_ChIP-Seq_K562_Human1.22866667
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22249945
57DROSHA_22980978_ChIP-Seq_HELA_Human1.18771559
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17608135
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16181162
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.14894100
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14450312
62MAF_26560356_Chip-Seq_TH2_Human1.13336411
63* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12434605
64GATA3_26560356_Chip-Seq_TH2_Human1.12329812
65* KDM2B_26808549_Chip-Seq_JURKAT_Human1.08473558
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06169675
67RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03010084
68GATA1_19941826_ChIP-Seq_K562_Human1.00211421
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99582742
70GATA2_19941826_ChIP-Seq_K562_Human0.99452226
71* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98125957
72GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95867597
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95488572
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95210668
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93110730
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91456274
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89334666
78SMRT_27268052_Chip-Seq_Bcells_Human0.89169617
79AR_21572438_ChIP-Seq_LNCaP_Human0.88789007
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87435684
81RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86484641
82PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85790306
83* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82878809
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81752735
85* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81396970
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.80429865
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.79457650
88ELK3_25401928_ChIP-Seq_HUVEC_Human0.78766168
89KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.76280928
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74345120
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.71727028
92AHR_22903824_ChIP-Seq_MCF-7_Human0.71007457
93KDM2B_26808549_Chip-Seq_K562_Human0.69895921
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.68778612
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.68181489
96CDX2_19796622_ChIP-Seq_MESCs_Mouse0.67967803
97RXR_22108803_ChIP-Seq_LS180_Human0.67959158
98CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67571831
99ARNT_22903824_ChIP-Seq_MCF-7_Human0.67322937
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.66545905
101EGR1_19032775_ChIP-ChIP_M12_Human0.65416404
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.64814258
103SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.63680414
104FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.62576794
105GATA1_22383799_ChIP-Seq_G1ME_Mouse0.62535731
106LXR_22292898_ChIP-Seq_THP-1_Human0.62245348
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.62128608
108IGF1R_20145208_ChIP-Seq_DFB_Human0.61448162
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.60112803
110FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.58434256
111EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.57812981
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.57644402
113STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.56259883
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55027007
115WT1_25993318_ChIP-Seq_PODOCYTE_Human0.54692967
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.54166838

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.48360986
2MP0000685_abnormal_immune_system3.43377479
3MP0005387_immune_system_phenotype3.38467306
4MP0001790_abnormal_immune_system3.38467306
5MP0005671_abnormal_response_to3.35481513
6MP0001800_abnormal_humoral_immune3.11746203
7MP0005000_abnormal_immune_tolerance2.91096909
8MP0002452_abnormal_antigen_presenting2.87253038
9MP0002419_abnormal_innate_immunity2.70444685
10MP0002723_abnormal_immune_serum2.66940168
11MP0002420_abnormal_adaptive_immunity2.64232822
12MP0001819_abnormal_immune_cell2.61894788
13MP0002148_abnormal_hypersensitivity_rea2.61460993
14MP0003436_decreased_susceptibility_to2.57849026
15MP0003763_abnormal_thymus_physiology2.55568526
16MP0003303_peritoneal_inflammation2.46514838
17MP0002166_altered_tumor_susceptibility2.46456164
18MP0005025_abnormal_response_to2.39588459
19MP0009785_altered_susceptibility_to2.32555629
20MP0000569_abnormal_digit_pigmentation2.28171826
21MP0004510_myositis2.21111481
22MP0002398_abnormal_bone_marrow2.18085659
23MP0006082_CNS_inflammation2.15738051
24MP0000716_abnormal_immune_system2.13300165
25MP0005464_abnormal_platelet_physiology2.05066988
26MP0005058_abnormal_lysosome_morphology2.02638576
27MP0002396_abnormal_hematopoietic_system2.00074597
28MP0003828_pulmonary_edema1.96412239
29MP0002006_tumorigenesis1.96086875
30MP0003300_gastrointestinal_ulcer1.90322317
31MP0005310_abnormal_salivary_gland1.86333984
32MP0003172_abnormal_lysosome_physiology1.85661645
33MP0002405_respiratory_system_inflammati1.81915531
34MP0003183_abnormal_peptide_metabolism1.74180033
35MP0000920_abnormal_myelination1.70716956
36MP0002254_reproductive_system_inflammat1.70372410
37MP0003690_abnormal_glial_cell1.70105911
38MP0000689_abnormal_spleen_morphology1.69214999
39MP0005174_abnormal_tail_pigmentation1.67884539
40MP0001873_stomach_inflammation1.64708684
41MP0002429_abnormal_blood_cell1.62995346
42MP0002722_abnormal_immune_system1.59856107
43MP0000465_gastrointestinal_hemorrhage1.58904224
44MP0004883_abnormal_blood_vessel1.58203631
45MP0010155_abnormal_intestine_physiology1.54660889
46MP0003724_increased_susceptibility_to1.53766175
47MP0002009_preneoplasia1.52976874
48MP0004808_abnormal_hematopoietic_stem1.51134318
49MP0000015_abnormal_ear_pigmentation1.48405854
50MP0001845_abnormal_inflammatory_respons1.46663420
51MP0000703_abnormal_thymus_morphology1.46176739
52MP0001533_abnormal_skeleton_physiology1.42732012
53MP0004947_skin_inflammation1.40871347
54MP0009278_abnormal_bone_marrow1.36371416
55MP0002132_abnormal_respiratory_system1.34168076
56MP0009333_abnormal_splenocyte_physiolog1.32670989
57MP0002933_joint_inflammation1.28899893
58MP0001853_heart_inflammation1.28872004
59MP0002277_abnormal_respiratory_mucosa1.23351779
60MP0005451_abnormal_body_composition1.22803469
61MP0002998_abnormal_bone_remodeling1.20409636
62MP0001851_eye_inflammation1.16979538
63MP0003191_abnormal_cellular_cholesterol1.15485279
64MP0002138_abnormal_hepatobiliary_system1.14445608
65MP0003329_amyloid_beta_deposits1.13877894
66MP0005164_abnormal_response_to1.04967134
67MP0003448_altered_tumor_morphology1.03681942
68MP0003656_abnormal_erythrocyte_physiolo1.02298517
69MP0003866_abnormal_defecation1.01027231
70MP0001348_abnormal_lacrimal_gland1.00790459
71MP0003045_fibrosis0.99296061
72MP0003075_altered_response_to0.99227676
73MP0005397_hematopoietic_system_phenotyp0.97807018
74MP0001545_abnormal_hematopoietic_system0.97807018
75MP0005167_abnormal_blood-brain_barrier0.96587843
76MP0004130_abnormal_muscle_cell0.94904056
77MP0002095_abnormal_skin_pigmentation0.94682566
78MP0008469_abnormal_protein_level0.92683813
79MP0003091_abnormal_cell_migration0.87571583
80MP0005075_abnormal_melanosome_morpholog0.85882869
81MP0000604_amyloidosis0.82951684
82MP0005388_respiratory_system_phenotype0.81418610
83MP0002133_abnormal_respiratory_system0.81418610
84MP0008569_lethality_at_weaning0.79743539
85MP0001346_abnormal_lacrimal_gland0.78055421
86MP0003221_abnormal_cardiomyocyte_apopto0.74693435
87MP0009763_increased_sensitivity_to0.73361618
88MP0004742_abnormal_vestibular_system0.73134863
89MP0009764_decreased_sensitivity_to0.72210714
90MP0001958_emphysema0.70589985
91MP0003633_abnormal_nervous_system0.68867199
92MP0000343_altered_response_to0.68390920
93MP0009765_abnormal_xenobiotic_induced0.67613731
94MP0000858_altered_metastatic_potential0.67561235
95MP0003453_abnormal_keratinocyte_physiol0.66903583
96MP0004381_abnormal_hair_follicle0.66811675
97MP0003787_abnormal_imprinting0.66360046
98MP0001663_abnormal_digestive_system0.65622760
99MP0005166_decreased_susceptibility_to0.63108977
100MP0002163_abnormal_gland_morphology0.61775443
101MP0005171_absent_coat_pigmentation0.59645555
102MP0008260_abnormal_autophagy0.59081024
103MP0000490_abnormal_crypts_of0.59049068
104MP0002332_abnormal_exercise_endurance0.58910939
105MP0004484_altered_response_of0.58569658
106MP0003279_aneurysm0.58441753
107MP0005390_skeleton_phenotype0.58135247
108MP0003632_abnormal_nervous_system0.57120327
109MP0000249_abnormal_blood_vessel0.56974737
110MP0005409_darkened_coat_color0.55536867
111MP0003634_abnormal_glial_cell0.55336873
112MP0006054_spinal_hemorrhage0.55317128
113MP0008874_decreased_physiological_sensi0.53948195
114MP0003795_abnormal_bone_structure0.53934447
115MP0000371_diluted_coat_color0.53855972
116MP0000767_abnormal_smooth_muscle0.52814251
117MP0005645_abnormal_hypothalamus_physiol0.51382963
118MP0000383_abnormal_hair_follicle0.48396580
119MP0003631_nervous_system_phenotype0.46994653
120MP0001986_abnormal_taste_sensitivity0.46556639

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.13893432
2Recurrent bacterial skin infections (HP:0005406)4.79420354
3Agammaglobulinemia (HP:0004432)4.58509661
4Eczematoid dermatitis (HP:0000976)4.44554847
5Recurrent fungal infections (HP:0002841)4.28348669
6Chronic otitis media (HP:0000389)4.28290395
7Cellulitis (HP:0100658)4.21856575
8Recurrent viral infections (HP:0004429)4.20271026
9Chronic mucocutaneous candidiasis (HP:0002728)4.02748722
10Recurrent cutaneous fungal infections (HP:0011370)4.02748722
11Gastrointestinal infarctions (HP:0005244)3.99588748
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.95430178
13Recurrent skin infections (HP:0001581)3.78337083
14Keratoconjunctivitis sicca (HP:0001097)3.75671562
15Panhypogammaglobulinemia (HP:0003139)3.73767142
16Keratoconjunctivitis (HP:0001096)3.47143093
17Meningitis (HP:0001287)3.42372012
18Inflammation of the large intestine (HP:0002037)3.35092550
19Colitis (HP:0002583)3.34205227
20Myositis (HP:0100614)3.33322209
21Mediastinal lymphadenopathy (HP:0100721)3.30987724
22Urticaria (HP:0001025)3.18758396
23Abnormality of T cell number (HP:0011839)3.15977978
24Recurrent bronchitis (HP:0002837)3.11605171
25T lymphocytopenia (HP:0005403)3.10138218
26Gastrointestinal inflammation (HP:0004386)3.09775937
27Obstructive lung disease (HP:0006536)3.03112352
28Chronic obstructive pulmonary disease (HP:0006510)3.03112352
29Abnormality of macrophages (HP:0004311)3.00281804
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.94393976
31Elevated erythrocyte sedimentation rate (HP:0003565)2.89413955
32Eosinophilia (HP:0001880)2.88101095
33Episodic fever (HP:0001954)2.84883558
34Hypochromic microcytic anemia (HP:0004840)2.83810986
35Spontaneous hematomas (HP:0007420)2.83799128
36Amyloidosis (HP:0011034)2.83293394
37Vasculitis (HP:0002633)2.82846925
38Optic neuritis (HP:0100653)2.80481441
39Retrobulbar optic neuritis (HP:0100654)2.80481441
40Peritonitis (HP:0002586)2.78752769
41Systemic lupus erythematosus (HP:0002725)2.76027255
42Stomatitis (HP:0010280)2.73891581
43Thyroiditis (HP:0100646)2.61205772
44Chronic diarrhea (HP:0002028)2.58209598
45Hypochromic anemia (HP:0001931)2.54486901
46Orchitis (HP:0100796)2.52997403
47Gastrointestinal stroma tumor (HP:0100723)2.52454594
48IgM deficiency (HP:0002850)2.52253011
49Recurrent gram-negative bacterial infections (HP:0005420)2.51131599
50Lymphopenia (HP:0001888)2.49460522
51Epistaxis (HP:0000421)2.48813180
52Abnormality of T cells (HP:0002843)2.48080346
53Osteomyelitis (HP:0002754)2.47963568
54Hemiplegia (HP:0002301)2.47684537
55Papilloma (HP:0012740)2.47177819
56Verrucae (HP:0200043)2.47177819
57Autoimmune thrombocytopenia (HP:0001973)2.46601136
58Hematochezia (HP:0002573)2.45885818
59Leukocytosis (HP:0001974)2.44123704
60Abnormality of the fingertips (HP:0001211)2.44050555
61Recurrent pneumonia (HP:0006532)2.44043698
62Abnormality of eosinophils (HP:0001879)2.43340283
63Increased cerebral lipofuscin (HP:0011813)2.43064877
64Fatigue (HP:0012378)2.42986335
65Abnormality of cells of the lymphoid lineage (HP:0012140)2.40360272
66Increased IgE level (HP:0003212)2.35972708
67Recurrent lower respiratory tract infections (HP:0002783)2.35572134
68Gingivitis (HP:0000230)2.34652894
69Abnormality of liposaccharide metabolism (HP:0010968)2.34286179
70Abnormality of glycosphingolipid metabolism (HP:0004343)2.34286179
71Abnormality of glycolipid metabolism (HP:0010969)2.34286179
72Pulmonary infiltrates (HP:0002113)2.33831220
73Periodontitis (HP:0000704)2.33253776
74Granulocytopenia (HP:0001913)2.32413411
75Slow saccadic eye movements (HP:0000514)2.32066176
76Chronic sinusitis (HP:0011109)2.30996449
77Prolonged bleeding time (HP:0003010)2.27226267
78Subacute progressive viral hepatitis (HP:0006572)2.27160010
79Anorexia (HP:0002039)2.26877555
80Abnormality of the pleura (HP:0002103)2.26563938
81Abnormality of the peritoneum (HP:0002585)2.22856870
82Increased neuronal autofluorescent lipopigment (HP:0002074)2.22204842
83Gangrene (HP:0100758)2.20753728
84Abnormality of the endocardium (HP:0004306)2.19765931
85Pustule (HP:0200039)2.18904359
86Arterial thrombosis (HP:0004420)2.18698904
87Vertigo (HP:0002321)2.15521661
88Absent frontal sinuses (HP:0002688)2.15385031
89Encephalitis (HP:0002383)2.14851194
90Recurrent sinusitis (HP:0011108)2.13574474
91Interstitial pulmonary disease (HP:0006530)2.11629226
92Loss of speech (HP:0002371)2.10825304
93Dysostosis multiplex (HP:0000943)2.10498182
94Sepsis (HP:0100806)2.09949605
95Nasal polyposis (HP:0100582)2.08347070
96Microcytic anemia (HP:0001935)2.08026968
97Gingival bleeding (HP:0000225)2.07343185
98Glomerulonephritis (HP:0000099)2.05109920
99Increased IgM level (HP:0003496)2.03641829
100Osteolytic defects of the hand bones (HP:0009699)2.00200598
101Osteolytic defects of the phalanges of the hand (HP:0009771)2.00200598
102Abnormality of T cell physiology (HP:0011840)2.00155002
103Emphysema (HP:0002097)1.98328403
104Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98083698
105Pulmonary embolism (HP:0002204)1.97095166
106Hemoptysis (HP:0002105)1.94452414
107Supranuclear gaze palsy (HP:0000605)1.94403658
108Chest pain (HP:0100749)1.94367094
109IgG deficiency (HP:0004315)1.93144326
110Hypergammaglobulinemia (HP:0010702)1.92763709
111Glomerulopathy (HP:0100820)1.91021394
112B lymphocytopenia (HP:0010976)1.89995338
113Abnormality of B cell number (HP:0010975)1.89995338
114Segmental peripheral demyelination/remyelination (HP:0003481)1.86641588
115Thrombocytosis (HP:0001894)1.86547654
116Restrictive lung disease (HP:0002091)1.84972537
117Skin ulcer (HP:0200042)1.84758540
118Persistence of primary teeth (HP:0006335)1.83806189
119Stomach cancer (HP:0012126)1.82471520
120Polyneuropathy (HP:0001271)1.82083922
121Viral hepatitis (HP:0006562)1.80995693
122Keratitis (HP:0000491)1.80514921
123Postural instability (HP:0002172)1.79827339
124Prostate neoplasm (HP:0100787)1.79070275
125Disinhibition (HP:0000734)1.78897205
126Increased CSF protein (HP:0002922)1.78792031
127Difficulty running (HP:0009046)1.77925569
128Papilledema (HP:0001085)1.77078959
129Abnormality of the prostate (HP:0008775)1.77049297
130Diplopia (HP:0000651)1.75231175
131Abnormality of binocular vision (HP:0011514)1.75231175
132Acne (HP:0001061)1.74074973
133Amaurosis fugax (HP:0100576)1.73526993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.95292610
2MAP3K143.21897673
3TYK22.94387953
4IRAK42.63275137
5MAP3K132.58658537
6EPHB12.54310535
7CSF1R2.53782054
8TXK2.41987325
9JAK32.41700582
10JAK12.36417726
11KIT2.30067566
12TGFBR22.22553492
13IKBKE2.16314171
14BLK2.15286859
15IKBKB1.92509653
16RIPK41.91899976
17CLK11.89301876
18BTK1.89150250
19ITK1.87418931
20ERN11.86563393
21FES1.80370245
22SYK1.73426108
23HCK1.65550689
24TBK11.64834220
25SIK21.62735569
26PKN11.58668369
27TEC1.54077557
28STK101.51803657
29FGFR31.51299466
30KSR21.48800728
31ZAP701.47416200
32LCK1.41113793
33TAOK11.39745102
34GRK61.36062221
35CSK1.30199156
36CHUK1.25188672
37MAP3K31.24950190
38CAMK1D1.23850230
39MAP3K11.22831843
40CAMK1G1.22565531
41FGFR41.22157251
42MAP3K111.13544379
43IRAK21.08189535
44PRKCQ1.07765682
45SIK31.03384708
46FGFR20.99768952
47LYN0.99055692
48FGR0.98832754
49TNK20.98123117
50MAP3K20.96724674
51PIK3CG0.95397046
52NLK0.95125783
53HIPK20.87889107
54JAK20.87576717
55SGK30.86823517
56PRPF4B0.86044380
57PRKCH0.83759576
58WNK10.82984616
59SGK2230.80791809
60SGK4940.80791809
61BMPR20.80505022
62RIPK10.78935365
63EPHA30.78781905
64TRPM70.77631002
65KSR10.77431452
66MARK30.76434574
67MAP2K40.76319583
68CAMKK10.75357192
69MAP3K60.73715390
70MAPKAPK50.73338485
71SGK20.73005599
72MAPK150.72545439
73LRRK20.70290808
74PTK2B0.69462764
75CDK190.69116979
76PDPK10.69040607
77IRAK30.67941267
78RAF10.66624275
79EEF2K0.65569186
80DAPK20.64147072
81PIM10.64125584
82GRK70.62433146
83PDGFRB0.61463310
84DMPK0.60794220
85MAPK120.57584845
86MAPKAPK20.57164773
87MAPK70.55923134
88STK40.55905462
89ADRBK20.54865438
90FYN0.53870518
91PRKD10.51294829
92MAP3K50.51158746
93PDK10.50664020
94ALK0.49822973
95PRKAA20.48759963
96PRKD20.48310266
97MARK20.48308087
98TAOK30.47052804
99RPS6KA60.46813962
100YES10.46139990
101DYRK1B0.46019231
102MAP3K100.45582312
103ABL10.45516758
104TAOK20.44223592
105PRKCD0.44090447
106STK380.40887640
107CAMK40.40562937
108MATK0.40376106
109STK110.40320452
110PRKCZ0.40089774
111TRIB30.40083811
112SGK10.39920351
113NEK90.37246869
114CDC42BPA0.36942534
115CDK120.36399061
116IRAK10.36220162
117CAMKK20.34435695
118NTRK30.33462564
119RPS6KA50.33450547
120MAP2K30.33293691
121RPS6KC10.32406414
122RPS6KL10.32406414
123RET0.31980805
124MAP3K70.31175483
125PTK60.31095240
126EGFR0.28500181

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.85713216
2B cell receptor signaling pathway_Homo sapiens_hsa046622.54984177
3Osteoclast differentiation_Homo sapiens_hsa043802.32750612
4Leishmaniasis_Homo sapiens_hsa051402.29029064
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.25673354
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.16371027
7Measles_Homo sapiens_hsa051621.89605658
8Toll-like receptor signaling pathway_Homo sapiens_hsa046201.87396544
9Chemokine signaling pathway_Homo sapiens_hsa040621.80446362
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79437447
11T cell receptor signaling pathway_Homo sapiens_hsa046601.79229641
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.77062347
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.73982442
14Hematopoietic cell lineage_Homo sapiens_hsa046401.55894492
15Toxoplasmosis_Homo sapiens_hsa051451.54407194
16Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50118547
17Antigen processing and presentation_Homo sapiens_hsa046121.48687082
18Allograft rejection_Homo sapiens_hsa053301.46386082
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.42491508
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40997991
21Graft-versus-host disease_Homo sapiens_hsa053321.40200845
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39831597
23Tuberculosis_Homo sapiens_hsa051521.39702811
24Staphylococcus aureus infection_Homo sapiens_hsa051501.39436858
25Pertussis_Homo sapiens_hsa051331.37081397
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.31974622
27TNF signaling pathway_Homo sapiens_hsa046681.30294749
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28681126
29Influenza A_Homo sapiens_hsa051641.25034941
30Pancreatic cancer_Homo sapiens_hsa052121.20734899
31Apoptosis_Homo sapiens_hsa042101.17366451
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.15480128
33Platelet activation_Homo sapiens_hsa046111.13045189
34Herpes simplex infection_Homo sapiens_hsa051681.12923766
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12644155
36Acute myeloid leukemia_Homo sapiens_hsa052211.12317887
37Lysosome_Homo sapiens_hsa041421.11641473
38Chronic myeloid leukemia_Homo sapiens_hsa052201.09680784
39Other glycan degradation_Homo sapiens_hsa005111.09668020
40Malaria_Homo sapiens_hsa051441.08798803
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05952565
42Salmonella infection_Homo sapiens_hsa051321.05567087
43Hepatitis B_Homo sapiens_hsa051611.04977111
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03937405
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.02648150
46Shigellosis_Homo sapiens_hsa051311.02030002
47Autoimmune thyroid disease_Homo sapiens_hsa053201.01835007
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01378756
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99484867
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98089879
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96322767
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96101922
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95876426
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93146456
55African trypanosomiasis_Homo sapiens_hsa051430.92049043
56Viral myocarditis_Homo sapiens_hsa054160.91695010
57Endometrial cancer_Homo sapiens_hsa052130.91693354
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88563045
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86063457
60Rheumatoid arthritis_Homo sapiens_hsa053230.86020768
61Hepatitis C_Homo sapiens_hsa051600.85611291
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.83314744
63Endocytosis_Homo sapiens_hsa041440.83043235
64Non-small cell lung cancer_Homo sapiens_hsa052230.82652535
65Colorectal cancer_Homo sapiens_hsa052100.82185934
66Long-term potentiation_Homo sapiens_hsa047200.81083523
67GnRH signaling pathway_Homo sapiens_hsa049120.80720775
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79938914
69Prolactin signaling pathway_Homo sapiens_hsa049170.78121242
70Olfactory transduction_Homo sapiens_hsa047400.76433318
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.76165380
72Notch signaling pathway_Homo sapiens_hsa043300.74016022
73MAPK signaling pathway_Homo sapiens_hsa040100.73553516
74Morphine addiction_Homo sapiens_hsa050320.72620749
75mTOR signaling pathway_Homo sapiens_hsa041500.72004540
76Renal cell carcinoma_Homo sapiens_hsa052110.71709708
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71328106
78Asthma_Homo sapiens_hsa053100.70924763
79Legionellosis_Homo sapiens_hsa051340.70423767
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69979600
81VEGF signaling pathway_Homo sapiens_hsa043700.66279297
82Small cell lung cancer_Homo sapiens_hsa052220.65983854
83Inositol phosphate metabolism_Homo sapiens_hsa005620.65781389
84Phagosome_Homo sapiens_hsa041450.65576206
85Estrogen signaling pathway_Homo sapiens_hsa049150.65366345
86HIF-1 signaling pathway_Homo sapiens_hsa040660.65049357
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63657632
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63024660
89HTLV-I infection_Homo sapiens_hsa051660.59584760
90Amoebiasis_Homo sapiens_hsa051460.58922888
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57255643
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.57230277
93Ras signaling pathway_Homo sapiens_hsa040140.56036633
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55124330
95Dorso-ventral axis formation_Homo sapiens_hsa043200.54772595
96Renin secretion_Homo sapiens_hsa049240.54130414
97Rap1 signaling pathway_Homo sapiens_hsa040150.53661557
98ErbB signaling pathway_Homo sapiens_hsa040120.52960535
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52844524
100Epstein-Barr virus infection_Homo sapiens_hsa051690.52817755
101Cholinergic synapse_Homo sapiens_hsa047250.52646645
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51681279
103Type II diabetes mellitus_Homo sapiens_hsa049300.51314739
104Viral carcinogenesis_Homo sapiens_hsa052030.50956312
105Ether lipid metabolism_Homo sapiens_hsa005650.50872466
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49714974
107FoxO signaling pathway_Homo sapiens_hsa040680.49670067
108Gastric acid secretion_Homo sapiens_hsa049710.49419400
109Choline metabolism in cancer_Homo sapiens_hsa052310.48874989
110Type I diabetes mellitus_Homo sapiens_hsa049400.47204683
111Pathways in cancer_Homo sapiens_hsa052000.47091716
112Glioma_Homo sapiens_hsa052140.46837945
113Long-term depression_Homo sapiens_hsa047300.45587318
114Prostate cancer_Homo sapiens_hsa052150.45528004
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45379082

Most similar genes based on co-expression Upload to Enrichr

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