RASSF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The RAS oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RASSF3, share a RAS association (RA) domain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.10070347
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.88206144
3negative regulation of cell killing (GO:0031342)5.88206144
4positive regulation of gamma-delta T cell activation (GO:0046645)5.87439534
5positive regulation by symbiont of host defense response (GO:0052509)5.64721807
6modulation by symbiont of host defense response (GO:0052031)5.64721807
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.64721807
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.64721807
9positive regulation by organism of defense response of other organism involved in symbiotic interact5.64721807
10modulation by symbiont of host immune response (GO:0052553)5.64721807
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.16256004
12antigen processing and presentation of endogenous antigen (GO:0019883)5.07092846
13regulation of B cell receptor signaling pathway (GO:0050855)5.04897900
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.70867040
15detection of other organism (GO:0098543)4.61111595
16neutrophil activation involved in immune response (GO:0002283)4.60766543
17macrophage activation involved in immune response (GO:0002281)4.60523806
18detection of molecule of bacterial origin (GO:0032490)4.49472804
19L-phenylalanine catabolic process (GO:0006559)4.45328015
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.45328015
21alpha-linolenic acid metabolic process (GO:0036109)4.43122004
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.41189835
23L-phenylalanine metabolic process (GO:0006558)4.41189835
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.37395681
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.35755921
26lysine metabolic process (GO:0006553)4.35280614
27lysine catabolic process (GO:0006554)4.35280614
28regulation of interferon-beta biosynthetic process (GO:0045357)4.34191742
29regulation of gamma-delta T cell activation (GO:0046643)4.31141159
30response to peptidoglycan (GO:0032494)4.30396635
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.26197817
32cellular extravasation (GO:0045123)4.23577087
33detection of bacterium (GO:0016045)4.23370232
34kynurenine metabolic process (GO:0070189)4.16101447
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.15789118
36detection of external biotic stimulus (GO:0098581)4.15513305
37complement activation, alternative pathway (GO:0006957)4.09767309
38aromatic amino acid family catabolic process (GO:0009074)4.06049495
39protein carboxylation (GO:0018214)4.04603134
40peptidyl-glutamic acid carboxylation (GO:0017187)4.04603134
41leukocyte aggregation (GO:0070486)4.03973249
42negative regulation of interleukin-12 production (GO:0032695)4.02314640
43glyoxylate metabolic process (GO:0046487)3.93655953
44response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.93556474
45response to host immune response (GO:0052572)3.93556474
46regulation of gamma-delta T cell differentiation (GO:0045586)3.92263642
47sulfur amino acid catabolic process (GO:0000098)3.91426152
48negative regulation of fibrinolysis (GO:0051918)3.88366682
49urea metabolic process (GO:0019627)3.86511610
50urea cycle (GO:0000050)3.86511610
51response to interleukin-15 (GO:0070672)3.85632584
52immunoglobulin mediated immune response (GO:0016064)3.83829695
53regulation of triglyceride catabolic process (GO:0010896)3.83462647
54cysteine metabolic process (GO:0006534)3.80716949
55antigen processing and presentation via MHC class Ib (GO:0002475)3.79048302
56regulation of protein activation cascade (GO:2000257)3.76999350
572-oxoglutarate metabolic process (GO:0006103)3.74614561
58response to host (GO:0075136)3.73668264
59response to host defenses (GO:0052200)3.73668264
60response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.73668264
61indole-containing compound catabolic process (GO:0042436)3.72951666
62indolalkylamine catabolic process (GO:0046218)3.72951666
63tryptophan catabolic process (GO:0006569)3.72951666
64bile acid biosynthetic process (GO:0006699)3.69199183
65negative regulation of lymphocyte mediated immunity (GO:0002707)3.67298304
66fatty acid transmembrane transport (GO:1902001)3.67294446
67microglial cell activation (GO:0001774)3.64278084
68neutrophil activation (GO:0042119)3.63704637
69B cell receptor signaling pathway (GO:0050853)3.63058853
70positive thymic T cell selection (GO:0045059)3.62478177
71regulation of complement activation (GO:0030449)3.61823779
72amino-acid betaine metabolic process (GO:0006577)3.61210384
73phospholipid homeostasis (GO:0055091)3.59773503
74detection of biotic stimulus (GO:0009595)3.58572817
75ethanol oxidation (GO:0006069)3.57057959
76tryptophan metabolic process (GO:0006568)3.55464814
77cellular response to interleukin-15 (GO:0071350)3.53902143
78high-density lipoprotein particle remodeling (GO:0034375)3.51993766
79nitrogen cycle metabolic process (GO:0071941)3.50889447
80negative thymic T cell selection (GO:0045060)3.49729084
81plasma lipoprotein particle clearance (GO:0034381)3.48655597
82negative T cell selection (GO:0043383)3.48391220
83regulation of fibrinolysis (GO:0051917)3.46947101
84homocysteine metabolic process (GO:0050667)3.46397988
85fatty acid beta-oxidation (GO:0006635)3.45624087
86respiratory burst (GO:0045730)3.44287440
87regulation of cholesterol homeostasis (GO:2000188)3.43315461
88myeloid cell activation involved in immune response (GO:0002275)3.38921398
89positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.38679503
90positive regulation of fatty acid beta-oxidation (GO:0032000)3.37810116
91macrophage activation (GO:0042116)3.37571315
92negative regulation of T cell mediated immunity (GO:0002710)3.37407326
93cellular ketone body metabolic process (GO:0046950)3.33312262
94serine family amino acid catabolic process (GO:0009071)3.32928695
95regulation of T cell tolerance induction (GO:0002664)3.31981981
96granulocyte activation (GO:0036230)3.31573650
97valine metabolic process (GO:0006573)3.31459161
98type I interferon signaling pathway (GO:0060337)3.31391765
99cellular response to type I interferon (GO:0071357)3.31391765
100carnitine shuttle (GO:0006853)3.30416408
101positive regulation of interferon-alpha production (GO:0032727)3.30314933
102fatty acid oxidation (GO:0019395)3.29715143
103response to type I interferon (GO:0034340)3.29345453
104phospholipid efflux (GO:0033700)3.27857869
105negative regulation of leukocyte mediated immunity (GO:0002704)3.27117729
106production of molecular mediator involved in inflammatory response (GO:0002532)3.25304799
107positive regulation of lipid catabolic process (GO:0050996)3.24491151
108lipid oxidation (GO:0034440)3.23464804
109reverse cholesterol transport (GO:0043691)3.22970290
110positive T cell selection (GO:0043368)3.22609683
111regulation of B cell differentiation (GO:0045577)3.22204266
112positive regulation of B cell differentiation (GO:0045579)3.21152458
113negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.20104997
114bile acid metabolic process (GO:0008206)3.19291733
115neutrophil mediated immunity (GO:0002446)3.19229187
116triglyceride homeostasis (GO:0070328)3.19073850
117acylglycerol homeostasis (GO:0055090)3.19073850
118dicarboxylic acid biosynthetic process (GO:0043650)3.18993467
119low-density lipoprotein particle clearance (GO:0034383)3.18913889
120acetyl-CoA metabolic process (GO:0006084)3.18671963
121negative regulation of sterol transport (GO:0032372)3.18647690
122negative regulation of cholesterol transport (GO:0032375)3.18647690
123B cell mediated immunity (GO:0019724)3.17936714
124regulation of tolerance induction (GO:0002643)3.17020630
125T cell selection (GO:0045058)3.15923305
126T cell migration (GO:0072678)3.13571671
127regulation of fatty acid beta-oxidation (GO:0031998)3.11421444
128fatty acid catabolic process (GO:0009062)3.10392575
129regulation of alpha-beta T cell proliferation (GO:0046640)3.08676153
130positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.08038087
131regulation of interferon-alpha production (GO:0032647)3.07730220
132regulation of sequestering of triglyceride (GO:0010889)3.06154449
133regulation of mast cell degranulation (GO:0043304)3.05950347
134protein-lipid complex remodeling (GO:0034368)3.05885265
135macromolecular complex remodeling (GO:0034367)3.05885265
136plasma lipoprotein particle remodeling (GO:0034369)3.05885265
137thymic T cell selection (GO:0045061)3.04688869
138aspartate family amino acid catabolic process (GO:0009068)3.04540689
139response to muramyl dipeptide (GO:0032495)3.03991040
140short-chain fatty acid metabolic process (GO:0046459)3.02643906
141carnitine metabolic process (GO:0009437)3.01550561
142interferon-gamma-mediated signaling pathway (GO:0060333)3.01257509
143regulation of cholesterol storage (GO:0010885)2.99442649
144alpha-amino acid catabolic process (GO:1901606)2.98896735
145regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.98504075
146defense response to protozoan (GO:0042832)2.97654455
147leukocyte migration involved in inflammatory response (GO:0002523)2.97507624
148myeloid leukocyte mediated immunity (GO:0002444)2.96978376
149dendritic cell migration (GO:0036336)2.95762004
150monocarboxylic acid catabolic process (GO:0072329)2.95562312
151regulation of cholesterol esterification (GO:0010872)2.95348413
152regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.94336142
153lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94289884
154growth hormone receptor signaling pathway (GO:0060396)2.93657953
155bile acid and bile salt transport (GO:0015721)2.93401668
156ethanol metabolic process (GO:0006067)2.93193438
157positive regulation of fatty acid oxidation (GO:0046321)2.92164385
158negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.91084390
159negative regulation of T-helper cell differentiation (GO:0045623)2.91084390
160positive regulation of triglyceride metabolic process (GO:0090208)2.89592406
161cholesterol homeostasis (GO:0042632)2.88644472
162dendritic cell chemotaxis (GO:0002407)2.88587279
163regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87611557
164cholesterol efflux (GO:0033344)2.87610089
165sterol homeostasis (GO:0055092)2.87375101
166plasma lipoprotein particle assembly (GO:0034377)2.87214705
167positive regulation of mast cell activation (GO:0033005)2.86660529
168ketone body metabolic process (GO:1902224)2.85605472
169cellular modified amino acid catabolic process (GO:0042219)2.85303295
170negative regulation of erythrocyte differentiation (GO:0045647)2.85262115
171germinal center formation (GO:0002467)2.85060238
172aromatic amino acid family metabolic process (GO:0009072)2.84146889
173regulation of fatty acid oxidation (GO:0046320)2.84060629
174bundle of His cell to Purkinje myocyte communication (GO:0086069)2.83346922
175regulation of regulatory T cell differentiation (GO:0045589)2.82718905
176surfactant homeostasis (GO:0043129)2.82681938
177positive regulation of triglyceride lipase activity (GO:0061365)2.82388826
178positive regulation of lipoprotein lipase activity (GO:0051006)2.82388826
179tolerance induction (GO:0002507)2.82048865
180cellular glucuronidation (GO:0052695)2.81794907
181leukocyte degranulation (GO:0043299)2.80497581
182regulation of T-helper 2 cell differentiation (GO:0045628)2.80450568
183fibrinolysis (GO:0042730)2.80406908
184tyrosine metabolic process (GO:0006570)2.79814871
185cellular amino acid catabolic process (GO:0009063)2.79272105
186positive regulation of tolerance induction (GO:0002645)2.79180445
187regulation of mast cell activation involved in immune response (GO:0033006)2.78608192
1884-hydroxyproline metabolic process (GO:0019471)2.76897132
189regulation of leukocyte degranulation (GO:0043300)2.76565506
190regulation of myeloid leukocyte mediated immunity (GO:0002886)2.76323109
191protein-lipid complex assembly (GO:0065005)2.76224967
192regulation of T cell mediated cytotoxicity (GO:0001914)2.75925077
193glutamate metabolic process (GO:0006536)2.75854668
194negative regulation of fatty acid biosynthetic process (GO:0045717)2.74230483
195positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.73174745
196regulation of natural killer cell mediated immunity (GO:0002715)2.72217357
197tricarboxylic acid metabolic process (GO:0072350)2.71236494
198positive regulation of lipid storage (GO:0010884)2.70271085
199regulation of triglyceride metabolic process (GO:0090207)2.70137861
200lipoprotein metabolic process (GO:0042157)2.69575264

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.22347400
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.21507797
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.83790779
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.76663001
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.39426631
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.24246870
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.15555495
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.95473452
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.90700014
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.80156641
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.77384169
12CLOCK_20551151_ChIP-Seq_293T_Human2.56726934
13SPI1_23547873_ChIP-Seq_NB4_Human2.54345281
14MYB_26560356_Chip-Seq_TH2_Human2.53733029
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53078670
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.42136365
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.41780099
18VDR_24763502_ChIP-Seq_THP-1_Human2.41173724
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.37232832
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36178842
21SCL_19346495_ChIP-Seq_HPC-7_Human2.28642526
22MYB_26560356_Chip-Seq_TH1_Human2.26949921
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.24285769
24RUNX1_22412390_ChIP-Seq_EML_Mouse2.13171884
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12259157
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.07230428
27IRF8_22096565_ChIP-ChIP_GC-B_Human2.00963971
28GATA1_22025678_ChIP-Seq_K562_Human2.00086926
29UTX_26944678_Chip-Seq_JUKART_Human1.99554615
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.92277633
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84815772
32ZNF263_19887448_ChIP-Seq_K562_Human1.82151309
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.72571569
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.72116997
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69300115
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67029522
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66495425
38* GATA3_27048872_Chip-Seq_THYMUS_Human1.65369620
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.63141794
40MAF_26560356_Chip-Seq_TH2_Human1.62911539
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.62544423
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62056373
43* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58855101
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.56955700
45* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55136240
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.54835717
47* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53897472
48TBX20_22328084_ChIP-Seq_HEART_Mouse1.53225561
49TBX20_22080862_ChIP-Seq_HEART_Mouse1.53225561
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53185931
51* PU_27001747_Chip-Seq_BMDM_Mouse1.52747148
52* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.50886520
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49041198
54* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48708288
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.48160440
56* FOXA2_19822575_ChIP-Seq_HepG2_Human1.47677370
57TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.47101401
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47065492
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.46046232
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44096945
61* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43844434
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42724398
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42679162
64* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39764264
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39737367
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39717070
67* GATA2_21666600_ChIP-Seq_HMVEC_Human1.39227781
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.38196399
69HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.36871076
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36592123
71* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32855050
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.32720730
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.30328267
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30177197
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27593532
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26382632
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26046097
78* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24572698
79* RACK7_27058665_Chip-Seq_MCF-7_Human1.22456003
80* GATA3_26560356_Chip-Seq_TH2_Human1.22452246
81TRIM28_21343339_ChIP-Seq_HEK293_Human1.21557651
82TCF7_22412390_ChIP-Seq_EML_Mouse1.21176678
83IRF8_21731497_ChIP-ChIP_J774_Mouse1.21170772
84* GATA4_25053715_ChIP-Seq_YYC3_Human1.19804222
85ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19746430
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19358213
87* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15913088
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14737995
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14665483
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13455938
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13329908
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11898031
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10664454
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10061138
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09525516
96LXR_22292898_ChIP-Seq_THP-1_Human1.08754335
97* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07797575
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06677580
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06188457
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05801648
101GATA1_19941826_ChIP-Seq_K562_Human1.04418583
102* KDM2B_26808549_Chip-Seq_JURKAT_Human1.04391069
103* GATA6_25053715_ChIP-Seq_YYC3_Human1.04321764
104EP300_21415370_ChIP-Seq_HL-1_Mouse1.04024063
105KDM2B_26808549_Chip-Seq_DND41_Human1.03824582
106MAF_26560356_Chip-Seq_TH1_Human1.02843561
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02603312
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02178328
109GATA2_19941826_ChIP-Seq_K562_Human1.02037415
110NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01178977
111LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00383754
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99794108
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99276365
114* HNF4A_19822575_ChIP-Seq_HepG2_Human0.98859624
115RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98603311
116* ATF3_27146783_Chip-Seq_COLON_Human0.97194995
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96907723
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96805867
119GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96145997
120RUNX1_27514584_Chip-Seq_MCF-7_Human0.95888907
121E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95361413
122* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94868392
123RUNX_20019798_ChIP-Seq_JUKART_Human0.92681427
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92666334
125* SOX2_20726797_ChIP-Seq_SW620_Human0.92255205
126FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92222633
127KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91852132
128* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91698388
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91102381
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.91095430
131TFEB_21752829_ChIP-Seq_HELA_Human0.90598600
132RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90470504
133* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89630212
134* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89448349
135SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88958585
136GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88255894
137GATA1_19941827_ChIP-Seq_MEL_Mouse0.87471416
138* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87088484
139* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86386385
140NCOR1_26117541_ChIP-Seq_K562_Human0.86367549
141VDR_21846776_ChIP-Seq_THP-1_Human0.85237692
142HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84167842
143VDR_24787735_ChIP-Seq_THP-1_Human0.83854766
144FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83824373
145SPI1_23127762_ChIP-Seq_K562_Human0.82259560
146TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82117906
147STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81877912
148SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81487716
149SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81487716
150TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81327634
151MYC_22102868_ChIP-Seq_BL_Human0.80341865
152CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79461632
153ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78535621
154CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78397283
155* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.78313803
156VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77657755
157* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77093260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.21035010
2MP0005360_urolithiasis4.66997375
3MP0005085_abnormal_gallbladder_physiolo4.06411056
4MP0005365_abnormal_bile_salt3.79744496
5MP0002138_abnormal_hepatobiliary_system3.10232376
6MP0008875_abnormal_xenobiotic_pharmacok3.02218781
7MP0005671_abnormal_response_to2.90573897
8MP0001800_abnormal_humoral_immune2.80202255
9MP0003252_abnormal_bile_duct2.74387280
10MP0009840_abnormal_foam_cell2.74322278
11MP0005000_abnormal_immune_tolerance2.62351874
12MP0002837_dystrophic_cardiac_calcinosis2.62168188
13MP0003763_abnormal_thymus_physiology2.50948601
14MP0010329_abnormal_lipoprotein_level2.47725938
15MP0003191_abnormal_cellular_cholesterol2.41188427
16MP0002723_abnormal_immune_serum2.40989532
17MP0002452_abnormal_antigen_presenting2.40713039
18MP0002420_abnormal_adaptive_immunity2.36592833
19MP0001819_abnormal_immune_cell2.34320241
20MP0003705_abnormal_hypodermis_morpholog2.33387745
21MP0003806_abnormal_nucleotide_metabolis2.30723694
22MP0005083_abnormal_biliary_tract2.28377727
23MP0002148_abnormal_hypersensitivity_rea2.10308377
24MP0006082_CNS_inflammation2.06772899
25MP0004381_abnormal_hair_follicle2.04523722
26MP0008260_abnormal_autophagy1.97040199
27MP0001666_abnormal_nutrient_absorption1.92991974
28MP0002398_abnormal_bone_marrow1.92682842
29MP0002405_respiratory_system_inflammati1.83254824
30MP0000716_abnormal_immune_system1.82166848
31MP0010368_abnormal_lymphatic_system1.80986005
32MP0004084_abnormal_cardiac_muscle1.79435684
33MP0003300_gastrointestinal_ulcer1.78637761
34MP0010155_abnormal_intestine_physiology1.76344432
35MP0004130_abnormal_muscle_cell1.75041196
36MP0000609_abnormal_liver_physiology1.74854412
37MP0005332_abnormal_amino_acid1.73855988
38MP0002254_reproductive_system_inflammat1.70928009
39MP0009333_abnormal_splenocyte_physiolog1.62748672
40MP0002006_tumorigenesis1.60539448
41MP0003303_peritoneal_inflammation1.58192240
42MP0002118_abnormal_lipid_homeostasis1.58169116
43MP0002396_abnormal_hematopoietic_system1.57456260
44MP0000689_abnormal_spleen_morphology1.56487067
45MP0010234_abnormal_vibrissa_follicle1.55344316
46MP0000465_gastrointestinal_hemorrhage1.54550426
47MP0002009_preneoplasia1.54459229
48MP0002722_abnormal_immune_system1.53101391
49MP0004510_myositis1.51767378
50MP0000703_abnormal_thymus_morphology1.50837638
51MP0005310_abnormal_salivary_gland1.50755494
52MP0002132_abnormal_respiratory_system1.50333314
53MP0005319_abnormal_enzyme/_coenzyme1.48936207
54MP0000858_altered_metastatic_potential1.47652414
55MP0002429_abnormal_blood_cell1.45562533
56MP0003866_abnormal_defecation1.42483240
57MP0003172_abnormal_lysosome_physiology1.41511986
58MP0004883_abnormal_blood_vessel1.40396269
59MP0005167_abnormal_blood-brain_barrier1.40380184
60MP0003566_abnormal_cell_adhesion1.36289822
61MP0003436_decreased_susceptibility_to1.36039309
62MP0003195_calcinosis1.33584670
63MP0003183_abnormal_peptide_metabolism1.32285588
64MP0005075_abnormal_melanosome_morpholog1.31626809
65MP0005330_cardiomyopathy1.31582329
66MP0004036_abnormal_muscle_relaxation1.30319331
67MP0001851_eye_inflammation1.28203302
68MP0009643_abnormal_urine_homeostasis1.28187811
69MP0000015_abnormal_ear_pigmentation1.25777644
70MP0002998_abnormal_bone_remodeling1.25301449
71MP0004019_abnormal_vitamin_homeostasis1.18038871
72MP0004185_abnormal_adipocyte_glucose1.17316021
73MP0005666_abnormal_adipose_tissue1.16599091
74MP0001873_stomach_inflammation1.16491832
75MP0010630_abnormal_cardiac_muscle1.16466477
76MP0003448_altered_tumor_morphology1.13050505
77MP0005164_abnormal_response_to1.11711207
78MP0003828_pulmonary_edema1.10480644
79MP0004087_abnormal_muscle_fiber1.09674621
80MP0005058_abnormal_lysosome_morphology1.08361029
81MP0002877_abnormal_melanocyte_morpholog1.07950409
82MP0005584_abnormal_enzyme/coenzyme_acti1.07698066
83MP0009764_decreased_sensitivity_to1.06320452
84MP0006138_congestive_heart_failure1.05460305
85MP0001544_abnormal_cardiovascular_syste1.05378695
86MP0005385_cardiovascular_system_phenoty1.05378695
87MP0003091_abnormal_cell_migration1.05341225
88MP0002277_abnormal_respiratory_mucosa1.05213925
89MP0003646_muscle_fatigue1.05136731
90MP0003868_abnormal_feces_composition1.03641816
91MP0004782_abnormal_surfactant_physiolog1.03460917
92MP0003724_increased_susceptibility_to1.02495038
93MP0005451_abnormal_body_composition1.01668640
94MP0001879_abnormal_lymphatic_vessel1.00871774
95MP0005670_abnormal_white_adipose0.99966291
96MP0002166_altered_tumor_susceptibility0.99133483
97MP0002972_abnormal_cardiac_muscle0.98942267
98MP0000343_altered_response_to0.98510183
99MP0004808_abnormal_hematopoietic_stem0.98388983
100MP0004215_abnormal_myocardial_fiber0.97639982
101MP0000598_abnormal_liver_morphology0.96991433
102MP0000685_abnormal_immune_system0.95188064
103MP0008469_abnormal_protein_level0.94036135
104MP0000767_abnormal_smooth_muscle0.91126214
105MP0001545_abnormal_hematopoietic_system0.90398634
106MP0005397_hematopoietic_system_phenotyp0.90398634
107MP0000750_abnormal_muscle_regeneration0.90132089
108MP0002971_abnormal_brown_adipose0.89568048
109MP0003045_fibrosis0.88380594
110MP0001835_abnormal_antigen_presentation0.86940844
111MP0000249_abnormal_blood_vessel0.85661066
112MP0000751_myopathy0.85597494
113MP0000371_diluted_coat_color0.84956613
114MP0009763_increased_sensitivity_to0.84811310
115MP0004947_skin_inflammation0.84759668
116MP0003221_abnormal_cardiomyocyte_apopto0.84282542
117MP0003690_abnormal_glial_cell0.83533068
118MP0001853_heart_inflammation0.83178166
119MP0008775_abnormal_heart_ventricle0.82930276
120MP0009278_abnormal_bone_marrow0.81599262
121MP0001790_abnormal_immune_system0.81447181
122MP0005387_immune_system_phenotype0.81447181
123MP0008004_abnormal_stomach_pH0.80685270
124MP0000604_amyloidosis0.79344179
125MP0002419_abnormal_innate_immunity0.79259177
126MP0003453_abnormal_keratinocyte_physiol0.78921689
127MP0001756_abnormal_urination0.78387665
128MP0005166_decreased_susceptibility_to0.78041826
129MP0002136_abnormal_kidney_physiology0.76281078
130MP0003075_altered_response_to0.76078831
131MP0005464_abnormal_platelet_physiology0.75837098
132MP0005620_abnormal_muscle_contractility0.74348427
133MP0000749_muscle_degeneration0.73366470
134MP0005390_skeleton_phenotype0.73306036
135MP0001845_abnormal_inflammatory_respons0.72791828
136MP0002933_joint_inflammation0.72268400
137MP0003279_aneurysm0.72172785
138MP0005076_abnormal_cell_differentiation0.71944068
139MP0003656_abnormal_erythrocyte_physiolo0.71774005
140MP0006054_spinal_hemorrhage0.70739366
141MP0004272_abnormal_basement_membrane0.70458653
142MP0005334_abnormal_fat_pad0.70336980
143MP0002269_muscular_atrophy0.70036061
144MP0005165_increased_susceptibility_to0.69991571
145MP0005408_hypopigmentation0.69703505
146MP0001533_abnormal_skeleton_physiology0.68995082
147MP0004484_altered_response_of0.68207038
148MP0000569_abnormal_digit_pigmentation0.67656987
149MP0005375_adipose_tissue_phenotype0.67563780
150MP0005023_abnormal_wound_healing0.67425373
151MP0008961_abnormal_basal_metabolism0.67375947
152MP0000490_abnormal_crypts_of0.67264585
153MP0009785_altered_susceptibility_to0.67034376
154MP0001663_abnormal_digestive_system0.67020224
155MP0005025_abnormal_response_to0.66893734
156MP0001881_abnormal_mammary_gland0.66840259
157MP0009642_abnormal_blood_homeostasis0.66739447
158MP0004858_abnormal_nervous_system0.66245541
159MP0005409_darkened_coat_color0.65793015
160MP0003795_abnormal_bone_structure0.61509008

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.37553804
2Recurrent bacterial skin infections (HP:0005406)5.28014436
3Recurrent abscess formation (HP:0002722)5.26507226
4Myositis (HP:0100614)4.90657754
5Orchitis (HP:0100796)4.73574597
6Intrahepatic cholestasis (HP:0001406)4.66662953
7Abnormality of macrophages (HP:0004311)4.64179636
8Optic neuritis (HP:0100653)4.53288857
9Retrobulbar optic neuritis (HP:0100654)4.53288857
10Xanthomatosis (HP:0000991)4.31358126
11Abnormality of monocarboxylic acid metabolism (HP:0010996)4.19862977
12Gastrointestinal infarctions (HP:0005244)4.11586660
13Complement deficiency (HP:0004431)4.06085743
14Recurrent fungal infections (HP:0002841)3.93962490
15Abnormality of aromatic amino acid family metabolism (HP:0004338)3.93196467
16Elevated erythrocyte sedimentation rate (HP:0003565)3.91742362
17Stomatitis (HP:0010280)3.90184257
18T lymphocytopenia (HP:0005403)3.88798281
19Hypoglycemic coma (HP:0001325)3.83088270
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.76948092
21Abnormality of T cell number (HP:0011839)3.72289379
22Mediastinal lymphadenopathy (HP:0100721)3.71006240
23Meningitis (HP:0001287)3.70698245
24Recurrent skin infections (HP:0001581)3.52612629
25Obstructive lung disease (HP:0006536)3.45172700
26Chronic obstructive pulmonary disease (HP:0006510)3.45172700
27Right ventricular cardiomyopathy (HP:0011663)3.44355473
28Keratoconjunctivitis sicca (HP:0001097)3.43097396
29Vasculitis (HP:0002633)3.42852256
30Hyperammonemia (HP:0001987)3.41666445
31Ketosis (HP:0001946)3.40730647
32Hyperlipoproteinemia (HP:0010980)3.40570557
33Encephalitis (HP:0002383)3.37223217
34Prolonged partial thromboplastin time (HP:0003645)3.32558581
35Hypobetalipoproteinemia (HP:0003563)3.30267098
36Chronic mucocutaneous candidiasis (HP:0002728)3.28795323
37Recurrent cutaneous fungal infections (HP:0011370)3.28795323
38Chest pain (HP:0100749)3.25507546
39Abnormality of the common coagulation pathway (HP:0010990)3.23175812
40Esophageal varix (HP:0002040)3.21269776
41Polycythemia (HP:0001901)3.18535749
42Gingivitis (HP:0000230)3.17470998
43Myocardial infarction (HP:0001658)3.16879230
44Hypoalphalipoproteinemia (HP:0003233)3.16396316
45Recurrent viral infections (HP:0004429)3.14717103
46Urticaria (HP:0001025)3.13981342
47Joint hemorrhage (HP:0005261)3.10534094
48Keratoconjunctivitis (HP:0001096)3.09225064
49Abnormality of fatty-acid metabolism (HP:0004359)3.07613712
50Abnormality of complement system (HP:0005339)3.06415593
51Ketoacidosis (HP:0001993)3.06273107
52Cellulitis (HP:0100658)3.06216684
53Abnormality of glutamine family amino acid metabolism (HP:0010902)3.05456030
54Arterial thrombosis (HP:0004420)3.05082097
55Hyperglycinuria (HP:0003108)3.03821810
56Hypolipoproteinemia (HP:0010981)3.02548712
57Recurrent gram-negative bacterial infections (HP:0005420)2.99371045
58Pulmonary infiltrates (HP:0002113)2.94353191
59Epidermoid cyst (HP:0200040)2.93968112
60Increased IgE level (HP:0003212)2.93667524
61Abnormality of T cells (HP:0002843)2.91271075
62Ventricular tachycardia (HP:0004756)2.89302153
63Hemoptysis (HP:0002105)2.85619291
64Sudden death (HP:0001699)2.84878764
65Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.82230819
66Systemic lupus erythematosus (HP:0002725)2.76872255
67Subacute progressive viral hepatitis (HP:0006572)2.76717799
68Abnormality of glycine metabolism (HP:0010895)2.70972814
69Abnormality of serine family amino acid metabolism (HP:0010894)2.70972814
70Hyperglycinemia (HP:0002154)2.70305731
71Inflammation of the large intestine (HP:0002037)2.68380042
72Prolonged bleeding time (HP:0003010)2.67655026
73Abnormality of the intrinsic pathway (HP:0010989)2.67010466
74Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.66356813
75Myoglobinuria (HP:0002913)2.66017298
76Peritonitis (HP:0002586)2.65181285
77Leukocytosis (HP:0001974)2.64139231
78Pustule (HP:0200039)2.63905292
79Abnormality of sulfur amino acid metabolism (HP:0004339)2.62119367
80Fat malabsorption (HP:0002630)2.62106001
81Gastrointestinal inflammation (HP:0004386)2.61639187
82Hypercholesterolemia (HP:0003124)2.57398833
83Autoimmune hemolytic anemia (HP:0001890)2.56137360
84Asymmetric septal hypertrophy (HP:0001670)2.54713936
85Osteomyelitis (HP:0002754)2.54281601
86Hematochezia (HP:0002573)2.52560982
87Viral hepatitis (HP:0006562)2.52536455
88Anorexia (HP:0002039)2.50406154
89Increased IgM level (HP:0003496)2.49815216
90Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.49485392
91Panhypogammaglobulinemia (HP:0003139)2.48770265
92Skin nodule (HP:0200036)2.46130726
93Hyporeflexia of lower limbs (HP:0002600)2.45378744
94Spontaneous hematomas (HP:0007420)2.45060965
95Epistaxis (HP:0000421)2.44356156
96Abnormality of purine metabolism (HP:0004352)2.41379552
97Colitis (HP:0002583)2.41199384
98Granulocytopenia (HP:0001913)2.40572624
99Lymphopenia (HP:0001888)2.40412568
100Hepatocellular carcinoma (HP:0001402)2.36992296
101Exercise-induced muscle cramps (HP:0003710)2.36548615
102Gout (HP:0001997)2.35366074
103Slow saccadic eye movements (HP:0000514)2.34825775
104Abnormality of cells of the lymphoid lineage (HP:0012140)2.34112421
105Abnormality of T cell physiology (HP:0011840)2.32166022
106Recurrent bronchitis (HP:0002837)2.30718965
107Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22446381
108Dicarboxylic aciduria (HP:0003215)2.21914747
109Abnormality of dicarboxylic acid metabolism (HP:0010995)2.21914747
110Abnormality of the peritoneum (HP:0002585)2.21190059
111Gastrointestinal stroma tumor (HP:0100723)2.20973818
112Eosinophilia (HP:0001880)2.19746379
113Hyperinsulinemic hypoglycemia (HP:0000825)2.18416084
114Gangrene (HP:0100758)2.16527286
115Sepsis (HP:0100806)2.15988217
116Interstitial pulmonary disease (HP:0006530)2.15628650
117Mitral stenosis (HP:0001718)2.15218290
118Hydroxyprolinuria (HP:0003080)2.15117192
119Abnormality of proline metabolism (HP:0010907)2.15117192
120Episodic fever (HP:0001954)2.13646139
121Amyloidosis (HP:0011034)2.13471304
122Atrioventricular block (HP:0001678)2.12484195
123Hemorrhage of the eye (HP:0011885)2.12040645
124Eczematoid dermatitis (HP:0000976)2.11785358
125Hypochromic anemia (HP:0001931)2.11526675
126Abnormality of nucleobase metabolism (HP:0010932)2.11047117
127IgM deficiency (HP:0002850)2.10148548
128Agammaglobulinemia (HP:0004432)2.10140554
129Metabolic acidosis (HP:0001942)2.09931830
130Exercise-induced myalgia (HP:0003738)2.09510599
131Glomerulonephritis (HP:0000099)2.09345194
132Hyperglycemia (HP:0003074)2.09272822
133Hypoglycemic seizures (HP:0002173)2.08819646
134Vascular calcification (HP:0004934)2.04992295
135Abnormality of the pleura (HP:0002103)2.04748856
136Hypergammaglobulinemia (HP:0010702)2.03512397
137Rhabdomyolysis (HP:0003201)2.03388199
138Muscle fiber splitting (HP:0003555)2.02650284
139Nephritis (HP:0000123)2.01407960
140Hypochromic microcytic anemia (HP:0004840)2.01388075
141Cholelithiasis (HP:0001081)2.01158054
142Increased connective tissue (HP:0009025)2.01151310
143Lipoatrophy (HP:0100578)2.00556357
144Amaurosis fugax (HP:0100576)1.99784728
145Skin ulcer (HP:0200042)1.99737275
146Lymphangioma (HP:0100764)1.98210024
147Palpitations (HP:0001962)1.98200144
148Abnormality of the fingertips (HP:0001211)1.96694067
149Abnormality of methionine metabolism (HP:0010901)1.96078217
150Abnormality of the endocardium (HP:0004306)1.95460572
151Late onset (HP:0003584)1.95170944
152Verrucae (HP:0200043)1.95153166
153Papilloma (HP:0012740)1.95153166
154Sensorimotor neuropathy (HP:0007141)1.94326593
155Chronic diarrhea (HP:0002028)1.94228183
156Abnormality of glycolipid metabolism (HP:0010969)1.94115555
157Abnormality of liposaccharide metabolism (HP:0010968)1.94115555
158Abnormality of glycosphingolipid metabolism (HP:0004343)1.94115555
159Glomerulopathy (HP:0100820)1.92906382
160Hyperbilirubinemia (HP:0002904)1.92122786
161Generalized aminoaciduria (HP:0002909)1.91845852
162Steatorrhea (HP:0002570)1.91429785
163Conjugated hyperbilirubinemia (HP:0002908)1.91061661
164Cardiovascular calcification (HP:0011915)1.90587464
165Stroke (HP:0001297)1.90146482
166Ocular albinism (HP:0001107)1.90030595
167Abnormal gallbladder morphology (HP:0012437)1.89441137
168Malnutrition (HP:0004395)1.89065089
169Aneurysm (HP:0002617)1.88501529
170Acute hepatic failure (HP:0006554)1.88493242
171Calf muscle hypertrophy (HP:0008981)1.88481730
172Autoimmune thrombocytopenia (HP:0001973)1.87886138
173Microcytic anemia (HP:0001935)1.86797756
174Abnormal cartilage morphology (HP:0002763)1.86293722
175Spastic diplegia (HP:0001264)1.86174191
176Restrictive lung disease (HP:0002091)1.85916601
177Thrombophlebitis (HP:0004418)1.85790426
178Pulmonary embolism (HP:0002204)1.85415657
179Visceral angiomatosis (HP:0100761)1.84751677
180Recurrent pneumonia (HP:0006532)1.84749291
181Abnormal platelet volume (HP:0011876)1.84269579
182Cerebral hemorrhage (HP:0001342)1.83456802
183Abnormality of eosinophils (HP:0001879)1.83227899
184Fatigue (HP:0012378)1.82540281
185Petechiae (HP:0000967)1.82167869
186Axonal loss (HP:0003447)1.81130229
187Segmental peripheral demyelination/remyelination (HP:0003481)1.81078350
188Conjunctival hamartoma (HP:0100780)1.79882066
189Loss of speech (HP:0002371)1.78886924
190Premature loss of primary teeth (HP:0006323)1.78874821
191Syncope (HP:0001279)1.76153641
192Heart block (HP:0012722)1.75890909
193Gingival bleeding (HP:0000225)1.75664040

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.48031789
2TRIB33.70482268
3ERN13.40209754
4PKN23.39948685
5BLK3.04156307
6TTN3.01429500
7IRAK42.90410383
8PRPF4B2.65087537
9BCKDK2.62637194
10FGFR42.38280306
11TIE12.36144220
12SIK12.26881374
13RIPK12.26115644
14PTK62.19504373
15EPHB12.12587559
16TXK1.96615297
17TNK21.96458737
18FES1.93536364
19TAOK31.90859753
20TGFBR21.87425810
21LATS11.71441069
22MAP2K31.70315097
23SMG11.67145033
24MYLK1.64335717
25MAP3K101.63426712
26TYK21.60009995
27DMPK1.54535603
28FGR1.53996881
29LRRK21.49763331
30SIK31.48092568
31SYK1.47737663
32TBK11.47134293
33FLT31.45521891
34MAP3K31.44627288
35KDR1.41629599
36FRK1.37190175
37MAP3K141.34772690
38JAK11.30440279
39STK101.29746081
40NEK91.29539760
41YES11.24915582
42STK241.22314330
43LMTK21.21313856
44LYN1.20623073
45CAMK1D1.19920000
46MST1R1.15715288
47INSRR1.15424883
48MAP4K11.14839156
49TEC1.14393218
50EPHA31.14178482
51MARK31.12949989
52FGFR31.10935089
53BMPR21.09454005
54LCK1.08604107
55MAP3K71.07483444
56CSK1.05950189
57PRKAA21.03854347
58JAK21.03506136
59IRAK11.02721345
60STK31.00325617
61IRAK20.95454390
62OBSCN0.94142876
63PTK20.91978916
64PDGFRA0.91704122
65PIK3CG0.87475717
66JAK30.85407570
67PRKD20.83021649
68EEF2K0.81631931
69CDK120.79751776
70TAOK20.77906962
71PIK3CA0.77263055
72GRK60.77119117
73RET0.76579167
74CDK60.76352770
75CHUK0.75737354
76ZAP700.75557500
77CAMK1G0.73561317
78MAP3K10.73148456
79MARK20.72980316
80MAPK110.72847223
81KSR20.70878839
82PDK40.70567461
83PDK30.70567461
84MAP3K130.70239123
85PRKD10.69105074
86CDC42BPA0.67562526
87BMX0.66212112
88MATK0.63962185
89MAP3K20.63429536
90MELK0.61321714
91MAP2K20.61254719
92PAK40.60873774
93TRPM70.58672111
94MAP3K110.57843882
95IRAK30.57813743
96PDPK10.57299796
97ERBB40.57026712
98WNK10.56457365
99BTK0.56298673
100GSK3A0.56292707
101PRKAA10.55328229
102FER0.54671594
103ITK0.54549321
104RAF10.52405654
105CAMKK20.52232959
106PDGFRB0.51788406
107MAPK120.51777657
108MET0.51535901
109MTOR0.51328146
110MAPKAPK30.51307847
111HIPK20.51283360
112FYN0.50887856
113DAPK20.50312471
114PIM10.50118367
115MAP3K60.49475433
116MAPK70.49296850
117PDK20.49188362
118CSF1R0.49132583
119KIT0.49022842
120IKBKE0.48574985
121SGK30.48178725
122NLK0.46745925
123GRK70.45886894
124EGFR0.45798342
125TAOK10.45359034
126IKBKB0.45035614
127PAK30.44571394
128MAP3K50.43225528
129EPHA20.42704602
130CAMKK10.42650928
131MAPKAPK20.41704881
132NEK10.41660812
133AKT30.41105799
134CDK40.41053088
135PRKCQ0.40452327
136MAP2K10.40075472
137RPS6KL10.39818583
138RPS6KC10.39818583
139TESK20.39355163
140STK38L0.39160660
141MOS0.39099817
142PDK10.39008111
143HCK0.38321931
144PTK2B0.37728677
145MAP3K80.37262952

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.85782968
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.44255239
3Nitrogen metabolism_Homo sapiens_hsa009103.07142151
4Fatty acid degradation_Homo sapiens_hsa000712.91104091
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.83184960
6Arginine biosynthesis_Homo sapiens_hsa002202.71402587
7Tryptophan metabolism_Homo sapiens_hsa003802.46870749
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46452618
9Allograft rejection_Homo sapiens_hsa053302.41699998
10Complement and coagulation cascades_Homo sapiens_hsa046102.39156121
11Graft-versus-host disease_Homo sapiens_hsa053322.39016416
12Autoimmune thyroid disease_Homo sapiens_hsa053202.27482783
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.26074970
14Primary immunodeficiency_Homo sapiens_hsa053402.26023382
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.20868453
16Propanoate metabolism_Homo sapiens_hsa006402.13468301
17Staphylococcus aureus infection_Homo sapiens_hsa051502.08019331
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.05091552
19PPAR signaling pathway_Homo sapiens_hsa033202.02097000
20Measles_Homo sapiens_hsa051621.99023940
21Tuberculosis_Homo sapiens_hsa051521.98683613
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.96155202
23Fatty acid metabolism_Homo sapiens_hsa012121.94803071
24Caffeine metabolism_Homo sapiens_hsa002321.94287541
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90530293
26T cell receptor signaling pathway_Homo sapiens_hsa046601.89930858
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.86761062
28Antigen processing and presentation_Homo sapiens_hsa046121.77863154
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77405277
30Hematopoietic cell lineage_Homo sapiens_hsa046401.69111067
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66012930
32Influenza A_Homo sapiens_hsa051641.65945082
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65471728
34Butanoate metabolism_Homo sapiens_hsa006501.64305297
35Malaria_Homo sapiens_hsa051441.62292284
36Peroxisome_Homo sapiens_hsa041461.61603156
37Type I diabetes mellitus_Homo sapiens_hsa049401.61547076
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.60723166
39beta-Alanine metabolism_Homo sapiens_hsa004101.59836835
40Legionellosis_Homo sapiens_hsa051341.51942474
41Histidine metabolism_Homo sapiens_hsa003401.51839947
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.50996575
43Chemokine signaling pathway_Homo sapiens_hsa040621.50713722
44Herpes simplex infection_Homo sapiens_hsa051681.49660430
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.47122133
46Starch and sucrose metabolism_Homo sapiens_hsa005001.43820406
47Non-small cell lung cancer_Homo sapiens_hsa052231.43240497
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42920760
49Bile secretion_Homo sapiens_hsa049761.42077403
50Phenylalanine metabolism_Homo sapiens_hsa003601.38510551
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35700654
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.34320443
53Carbon metabolism_Homo sapiens_hsa012001.34286081
54Hepatitis B_Homo sapiens_hsa051611.32878783
55Asthma_Homo sapiens_hsa053101.32576911
56Chemical carcinogenesis_Homo sapiens_hsa052041.29107934
57Fat digestion and absorption_Homo sapiens_hsa049751.27116514
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25959539
59Selenocompound metabolism_Homo sapiens_hsa004501.23050034
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22838273
61Pyruvate metabolism_Homo sapiens_hsa006201.21504733
62Platelet activation_Homo sapiens_hsa046111.18327517
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16797074
64Sulfur metabolism_Homo sapiens_hsa009201.16547539
65Phagosome_Homo sapiens_hsa041451.09686311
66ABC transporters_Homo sapiens_hsa020101.09334262
67Renal cell carcinoma_Homo sapiens_hsa052111.09271233
68Retinol metabolism_Homo sapiens_hsa008301.09246870
69Lysine degradation_Homo sapiens_hsa003101.08795929
70Apoptosis_Homo sapiens_hsa042101.06267914
71Insulin resistance_Homo sapiens_hsa049311.05619553
72VEGF signaling pathway_Homo sapiens_hsa043701.01961770
73Tyrosine metabolism_Homo sapiens_hsa003501.01622501
74Shigellosis_Homo sapiens_hsa051310.99297684
75Endometrial cancer_Homo sapiens_hsa052130.94684171
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.93536903
77African trypanosomiasis_Homo sapiens_hsa051430.92458997
78Other glycan degradation_Homo sapiens_hsa005110.92379564
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.91455254
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.89914223
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88705830
82Biosynthesis of amino acids_Homo sapiens_hsa012300.87649234
83Prostate cancer_Homo sapiens_hsa052150.87159425
84Rheumatoid arthritis_Homo sapiens_hsa053230.86969795
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.86969424
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86463630
87Thyroid cancer_Homo sapiens_hsa052160.84175075
88FoxO signaling pathway_Homo sapiens_hsa040680.83584254
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81849282
90Salmonella infection_Homo sapiens_hsa051320.81444844
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77453789
92Viral carcinogenesis_Homo sapiens_hsa052030.77190804
93Epstein-Barr virus infection_Homo sapiens_hsa051690.77174063
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76227271
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76070687
96mTOR signaling pathway_Homo sapiens_hsa041500.75998408
97HTLV-I infection_Homo sapiens_hsa051660.75933896
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75509041
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.75268958
100Endocytosis_Homo sapiens_hsa041440.72691314
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72136316
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.71317895
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70392185
104Arginine and proline metabolism_Homo sapiens_hsa003300.70168547
105Glycerolipid metabolism_Homo sapiens_hsa005610.69417711
106Colorectal cancer_Homo sapiens_hsa052100.69384553
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.67785013
108Fatty acid elongation_Homo sapiens_hsa000620.67613232
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67381459
110Fatty acid biosynthesis_Homo sapiens_hsa000610.66644841
111Choline metabolism in cancer_Homo sapiens_hsa052310.66138495
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.65975145
113Notch signaling pathway_Homo sapiens_hsa043300.64707140
114Dorso-ventral axis formation_Homo sapiens_hsa043200.64348333
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63565737
116HIF-1 signaling pathway_Homo sapiens_hsa040660.63270891
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61297769
118Inositol phosphate metabolism_Homo sapiens_hsa005620.60744833
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60042760
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59984923
121GnRH signaling pathway_Homo sapiens_hsa049120.55305761
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54878176
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54114114
124Leishmaniasis_Homo sapiens_hsa051400.53203647
125Toxoplasmosis_Homo sapiens_hsa051450.52640995
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.52391361
127Pentose phosphate pathway_Homo sapiens_hsa000300.52198680
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52166376
129Dilated cardiomyopathy_Homo sapiens_hsa054140.51599512
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51283621
131Amoebiasis_Homo sapiens_hsa051460.50856809
132ErbB signaling pathway_Homo sapiens_hsa040120.48906962
133Folate biosynthesis_Homo sapiens_hsa007900.48467702
134Vitamin digestion and absorption_Homo sapiens_hsa049770.47605174
135Glioma_Homo sapiens_hsa052140.47197827
136Osteoclast differentiation_Homo sapiens_hsa043800.47010069
137AMPK signaling pathway_Homo sapiens_hsa041520.44159669
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43703119
139Adherens junction_Homo sapiens_hsa045200.43350405
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42871208
141Viral myocarditis_Homo sapiens_hsa054160.42545425
142MAPK signaling pathway_Homo sapiens_hsa040100.41749567
143Galactose metabolism_Homo sapiens_hsa000520.41428161
144Insulin signaling pathway_Homo sapiens_hsa049100.41414802
145Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40163298
146Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40127087
147Sulfur relay system_Homo sapiens_hsa041220.38989132
148Focal adhesion_Homo sapiens_hsa045100.37962144
149Small cell lung cancer_Homo sapiens_hsa052220.37281576
150Prion diseases_Homo sapiens_hsa050200.35439904
151Glycosaminoglycan degradation_Homo sapiens_hsa005310.34872482
152Glucagon signaling pathway_Homo sapiens_hsa049220.31427976
153Cyanoamino acid metabolism_Homo sapiens_hsa004600.30710194
154Glutathione metabolism_Homo sapiens_hsa004800.30584443
155Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29423178
156Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29306859
157Pertussis_Homo sapiens_hsa051330.29277254
158B cell receptor signaling pathway_Homo sapiens_hsa046620.29138507
159Acute myeloid leukemia_Homo sapiens_hsa052210.28265538
160NF-kappa B signaling pathway_Homo sapiens_hsa040640.28159470
161Bladder cancer_Homo sapiens_hsa052190.27946145
162Lysosome_Homo sapiens_hsa041420.27604638
163Central carbon metabolism in cancer_Homo sapiens_hsa052300.27354310
164Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27110780
165Fructose and mannose metabolism_Homo sapiens_hsa000510.26653161
166Proteoglycans in cancer_Homo sapiens_hsa052050.22796508
167Chronic myeloid leukemia_Homo sapiens_hsa052200.22339794
168TNF signaling pathway_Homo sapiens_hsa046680.22298958
169AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21858080
170Hepatitis C_Homo sapiens_hsa051600.20267506
171Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19972297
172Pancreatic cancer_Homo sapiens_hsa052120.19711932
173Prolactin signaling pathway_Homo sapiens_hsa049170.18551467

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