RASSF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.47685219
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.99426402
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.99426402
4antigen processing and presentation of endogenous antigen (GO:0019883)6.37057182
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.88526107
6regulation of gamma-delta T cell differentiation (GO:0045586)5.85815630
7regulation of gamma-delta T cell activation (GO:0046643)5.43225141
8negative T cell selection (GO:0043383)5.35806951
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.35463305
10negative regulation of cell killing (GO:0031342)5.35463305
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.30041504
12leukocyte aggregation (GO:0070486)5.27375070
13negative thymic T cell selection (GO:0045060)5.19886297
14regulation of B cell receptor signaling pathway (GO:0050855)5.14661594
15response to interleukin-15 (GO:0070672)4.95810467
16cellular response to interleukin-15 (GO:0071350)4.85435180
17positive thymic T cell selection (GO:0045059)4.84395937
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.59461662
19positive regulation by organism of defense response of other organism involved in symbiotic interact4.59461662
20modulation by symbiont of host immune response (GO:0052553)4.59461662
21positive regulation by symbiont of host defense response (GO:0052509)4.59461662
22modulation by symbiont of host defense response (GO:0052031)4.59461662
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.59461662
24regulation of B cell differentiation (GO:0045577)4.57253731
25positive regulation of B cell differentiation (GO:0045579)4.56634729
26interferon-gamma production (GO:0032609)4.40320650
27thymic T cell selection (GO:0045061)4.34714889
28positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.32127967
29positive T cell selection (GO:0043368)4.28649354
30detection of other organism (GO:0098543)4.25268827
31mast cell activation (GO:0045576)4.19304434
32negative regulation of interleukin-12 production (GO:0032695)4.17071931
33neutrophil activation involved in immune response (GO:0002283)4.13887950
34detection of bacterium (GO:0016045)4.12215315
35T cell selection (GO:0045058)4.11883610
36T cell migration (GO:0072678)4.09475521
37B cell receptor signaling pathway (GO:0050853)4.09245566
38antigen processing and presentation via MHC class Ib (GO:0002475)4.05348509
39regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.04621136
40response to peptidoglycan (GO:0032494)4.04304783
41regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.96876086
42macrophage activation involved in immune response (GO:0002281)3.94431690
43negative regulation of T cell mediated immunity (GO:0002710)3.93525740
44regulation of isotype switching to IgG isotypes (GO:0048302)3.92663056
45regulation of T cell receptor signaling pathway (GO:0050856)3.90943025
46Arp2/3 complex-mediated actin nucleation (GO:0034314)3.84519725
47antigen receptor-mediated signaling pathway (GO:0050851)3.79820370
48T cell homeostasis (GO:0043029)3.75335462
49T cell receptor signaling pathway (GO:0050852)3.74123611
50regulation of interleukin-12 biosynthetic process (GO:0045075)3.64127977
51negative regulation of erythrocyte differentiation (GO:0045647)3.60083759
52T cell costimulation (GO:0031295)3.59866342
53lymphocyte costimulation (GO:0031294)3.55088291
54ribosomal small subunit assembly (GO:0000028)3.54283214
55negative regulation of leukocyte mediated immunity (GO:0002704)3.53928555
56response to muramyl dipeptide (GO:0032495)3.53722131
57detection of external biotic stimulus (GO:0098581)3.49737797
58neutrophil activation (GO:0042119)3.48396835
59regulation of interferon-beta biosynthetic process (GO:0045357)3.47158926
60negative regulation of phagocytosis (GO:0050765)3.46616066
61mast cell degranulation (GO:0043303)3.44567551
62mast cell activation involved in immune response (GO:0002279)3.44567551
63regulation of tolerance induction (GO:0002643)3.44155189
64tolerance induction (GO:0002507)3.43921790
65regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.40117616
66regulation of alpha-beta T cell proliferation (GO:0046640)3.39742392
67regulation of T cell tolerance induction (GO:0002664)3.39646055
68positive regulation of granulocyte differentiation (GO:0030854)3.35420846
69regulation of natural killer cell mediated immunity (GO:0002715)3.34773491
70regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.34773491
71myeloid cell activation involved in immune response (GO:0002275)3.34305169
72negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.32875141
73activated T cell proliferation (GO:0050798)3.32621987
74granulocyte activation (GO:0036230)3.32380022
75megakaryocyte development (GO:0035855)3.30214594
76respiratory burst (GO:0045730)3.29715717
77germinal center formation (GO:0002467)3.27669151
78myeloid dendritic cell activation (GO:0001773)3.27290760
79positive regulation of interleukin-2 production (GO:0032743)3.27147341
80response to host immune response (GO:0052572)3.26570708
81response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.26570708
82immunoglobulin mediated immune response (GO:0016064)3.26432286
83negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.26017419
84regulation of interleukin-2 biosynthetic process (GO:0045076)3.25869757
85positive regulation of natural killer cell mediated immunity (GO:0002717)3.24575713
86positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.24575713
87mature B cell differentiation (GO:0002335)3.22527272
88regulation of response to interferon-gamma (GO:0060330)3.20651356
89detection of molecule of bacterial origin (GO:0032490)3.20542291
90lymphocyte homeostasis (GO:0002260)3.19745966
91mucosal-associated lymphoid tissue development (GO:0048537)3.18440631
92Peyers patch development (GO:0048541)3.18440631
93positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.17983257
94mature B cell differentiation involved in immune response (GO:0002313)3.17483679
95regulation of T cell mediated cytotoxicity (GO:0001914)3.17386805
96positive regulation of alpha-beta T cell proliferation (GO:0046641)3.16645455
97NIK/NF-kappaB signaling (GO:0038061)3.16457072
98B cell mediated immunity (GO:0019724)3.16249219
99cellular extravasation (GO:0045123)3.15297847
100regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.14271446
101detection of biotic stimulus (GO:0009595)3.13982175
102definitive hemopoiesis (GO:0060216)3.13923368
103leukocyte cell-cell adhesion (GO:0007159)3.11874556
104negative regulation of T cell receptor signaling pathway (GO:0050860)3.11398600
105negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.11185859
106positive regulation of isotype switching (GO:0045830)3.07338655
107leukocyte degranulation (GO:0043299)3.06608917
108interferon-gamma-mediated signaling pathway (GO:0060333)3.06579050
109positive regulation of macrophage differentiation (GO:0045651)3.05903609
110regulation of regulatory T cell differentiation (GO:0045589)3.05555689
111regulation of dendritic cell antigen processing and presentation (GO:0002604)3.01879460
112response to host (GO:0075136)3.01809537
113response to host defenses (GO:0052200)3.01809537
114response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.01809537
115response to type I interferon (GO:0034340)3.01800514
116natural killer cell activation (GO:0030101)3.00914238
117positive regulation of T cell mediated cytotoxicity (GO:0001916)3.00840151
118JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.00530844
119type I interferon signaling pathway (GO:0060337)2.98246804
120cellular response to type I interferon (GO:0071357)2.98246804
121lymph node development (GO:0048535)2.96744988
122regulation of leukocyte mediated cytotoxicity (GO:0001910)2.96684404
123response to protozoan (GO:0001562)2.95368424
124regulation of mast cell degranulation (GO:0043304)2.94932575
125microglial cell activation (GO:0001774)2.93504600
126regulation of B cell mediated immunity (GO:0002712)2.93453276
127lipopolysaccharide-mediated signaling pathway (GO:0031663)2.92641340
128leukocyte homeostasis (GO:0001776)2.90764968
129macrophage activation (GO:0042116)2.90650556
130natural killer cell differentiation (GO:0001779)2.90569198
131negative regulation of innate immune response (GO:0045824)2.89246700
132T cell differentiation (GO:0030217)2.87971351
133positive regulation of tolerance induction (GO:0002645)2.87541317
134regulation of isotype switching (GO:0045191)2.87445256
135defense response to protozoan (GO:0042832)2.87195220
136regulation of immunoglobulin mediated immune response (GO:0002889)2.87055618
137production of molecular mediator involved in inflammatory response (GO:0002532)2.86716966
138positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.86359126
139immune response-activating cell surface receptor signaling pathway (GO:0002429)2.85367177
140neutrophil mediated immunity (GO:0002446)2.85151135
141myeloid dendritic cell differentiation (GO:0043011)2.84746986
142negative regulation of lymphocyte mediated immunity (GO:0002707)2.84489076
143positive regulation of immunoglobulin mediated immune response (GO:0002891)2.83491322
144positive regulation of B cell mediated immunity (GO:0002714)2.83491322
145positive regulation of natural killer cell differentiation (GO:0032825)2.83451485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.03793459
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.75263715
3* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.69471335
4E2F7_22180533_ChIP-Seq_HELA_Human4.52861146
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.84208104
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.69557490
7MYC_22102868_ChIP-Seq_BL_Human3.14755364
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.12267881
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.03849168
10SCL_19346495_ChIP-Seq_HPC-7_Human2.97333807
11* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.92275949
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.92182464
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.91996215
14* RUNX_20019798_ChIP-Seq_JUKART_Human2.88333342
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.81943471
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.81729956
17MYB_26560356_Chip-Seq_TH2_Human2.81263026
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.76604035
19VDR_21846776_ChIP-Seq_THP-1_Human2.66987784
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.65919785
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.52932335
22* MAF_26560356_Chip-Seq_TH1_Human2.51695552
23* MYB_26560356_Chip-Seq_TH1_Human2.36130896
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.36032213
25* SPI1_23547873_ChIP-Seq_NB4_Human2.34970571
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.34542478
27IRF8_27001747_Chip-Seq_BMDM_Mouse2.32189588
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31699432
29UTX_26944678_Chip-Seq_JUKART_Human2.29788656
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23688422
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.14166759
32GATA1_22025678_ChIP-Seq_K562_Human2.11346870
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.08862328
34NOTCH1_21737748_ChIP-Seq_TLL_Human2.07877815
35ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06778088
36VDR_24763502_ChIP-Seq_THP-1_Human2.02563893
37* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01349215
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.96043417
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.89391446
40* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84704715
41* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83769829
42TCF7_22412390_ChIP-Seq_EML_Mouse1.81487464
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.79354744
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75867263
45MAF_26560356_Chip-Seq_TH2_Human1.75476195
46GATA3_27048872_Chip-Seq_THYMUS_Human1.69218563
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68802190
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.65530254
49* SPI1_23127762_ChIP-Seq_K562_Human1.63100383
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59674450
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.58671732
52VDR_24787735_ChIP-Seq_THP-1_Human1.55854062
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54945379
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52746648
55GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.48928194
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.48794990
57* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45937762
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44723836
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38298074
60* PU_27001747_Chip-Seq_BMDM_Mouse1.33179391
61CIITA_25753668_ChIP-Seq_RAJI_Human1.33149282
62* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31647714
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29841513
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29001657
65VDR_23849224_ChIP-Seq_CD4+_Human1.28450458
66E2F4_17652178_ChIP-ChIP_JURKAT_Human1.27743355
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24846546
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20638243
69FOXP3_21729870_ChIP-Seq_TREG_Human1.19091989
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.19016842
71* KDM2B_26808549_Chip-Seq_DND41_Human1.18371472
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17713091
73GATA3_26560356_Chip-Seq_TH2_Human1.16622493
74* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14417816
75GATA1_19941826_ChIP-Seq_K562_Human1.13749965
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12019574
77CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11440232
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.10350276
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09481589
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.08682884
81* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06612025
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04414256
83* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00572224
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99652843
85STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99082599
86* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99002846
87LXR_22292898_ChIP-Seq_THP-1_Human0.98801545
88CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98528223
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97884752
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97331643
91FOXM1_23109430_ChIP-Seq_U2OS_Human0.97201432
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96512980
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94150661
94MYC_18555785_ChIP-Seq_MESCs_Mouse0.91108967
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91087259
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90903346
97BCOR_27268052_Chip-Seq_Bcells_Human0.90518989
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90369750
99GABP_17652178_ChIP-ChIP_JURKAT_Human0.90035646
100NCOR1_26117541_ChIP-Seq_K562_Human0.89994458
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89612768
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89569295
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89171516
104GATA2_21666600_ChIP-Seq_HMVEC_Human0.87098265
105GATA2_19941826_ChIP-Seq_K562_Human0.86588580
106ETS1_22383799_ChIP-Seq_G1ME_Mouse0.85881710
107* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85809729
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.83483970
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83359331
110SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.82341582
111NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81500292
112IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81114918
113XRN2_22483619_ChIP-Seq_HELA_Human0.80770952
114NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.80130681
115* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.78589856
116ELK1_19687146_ChIP-ChIP_HELA_Human0.74399449
117E2F1_21310950_ChIP-Seq_MCF-7_Human0.73957244
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73656273
119BCL6_27268052_Chip-Seq_Bcells_Human0.72624371
120MYC_18358816_ChIP-ChIP_MESCs_Mouse0.71569185
121EST1_17652178_ChIP-ChIP_JURKAT_Human0.71089802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.15092319
2MP0003763_abnormal_thymus_physiology4.15038284
3MP0005671_abnormal_response_to4.01453572
4MP0000685_abnormal_immune_system3.47179867
5MP0001800_abnormal_humoral_immune3.22113124
6MP0009785_altered_susceptibility_to3.09007020
7MP0002396_abnormal_hematopoietic_system3.07822719
8MP0005000_abnormal_immune_tolerance2.89617822
9MP0005387_immune_system_phenotype2.87403179
10MP0001790_abnormal_immune_system2.87403179
11* MP0002420_abnormal_adaptive_immunity2.85338515
12* MP0001819_abnormal_immune_cell2.81630826
13MP0002723_abnormal_immune_serum2.80488473
14* MP0002398_abnormal_bone_marrow2.77584782
15* MP0002452_abnormal_antigen_presenting2.75754113
16MP0003436_decreased_susceptibility_to2.73752983
17MP0005025_abnormal_response_to2.71044825
18MP0002166_altered_tumor_susceptibility2.56534650
19* MP0000716_abnormal_immune_system2.43353010
20MP0009333_abnormal_splenocyte_physiolog2.39433275
21MP0002419_abnormal_innate_immunity2.34923317
22* MP0000689_abnormal_spleen_morphology2.31270606
23MP0002405_respiratory_system_inflammati2.30413776
24MP0005464_abnormal_platelet_physiology2.28472836
25* MP0002722_abnormal_immune_system2.26613371
26MP0002148_abnormal_hypersensitivity_rea2.25391209
27MP0003724_increased_susceptibility_to2.22052810
28MP0001873_stomach_inflammation2.20684071
29MP0010155_abnormal_intestine_physiology2.14776854
30MP0002006_tumorigenesis2.13593519
31* MP0000703_abnormal_thymus_morphology2.12447422
32* MP0002429_abnormal_blood_cell2.07779932
33MP0001853_heart_inflammation2.05796639
34MP0004808_abnormal_hematopoietic_stem2.03447854
35MP0003303_peritoneal_inflammation1.96609191
36MP0004510_myositis1.94197208
37MP0006082_CNS_inflammation1.88953553
38MP0003866_abnormal_defecation1.86557990
39MP0004947_skin_inflammation1.86415522
40MP0003300_gastrointestinal_ulcer1.85687457
41MP0001545_abnormal_hematopoietic_system1.81318217
42MP0005397_hematopoietic_system_phenotyp1.81318217
43MP0001845_abnormal_inflammatory_respons1.81260302
44MP0000465_gastrointestinal_hemorrhage1.79704261
45MP0002933_joint_inflammation1.65463849
46MP0005174_abnormal_tail_pigmentation1.63469490
47MP0005075_abnormal_melanosome_morpholog1.61687889
48MP0005451_abnormal_body_composition1.52270599
49MP0000490_abnormal_crypts_of1.42847803
50MP0000858_altered_metastatic_potential1.41078974
51MP0008260_abnormal_autophagy1.28945056
52MP0008469_abnormal_protein_level1.28391958
53MP0009278_abnormal_bone_marrow1.24450951
54MP0001533_abnormal_skeleton_physiology1.18673271
55MP0002277_abnormal_respiratory_mucosa1.17304977
56MP0002019_abnormal_tumor_incidence1.16619173
57MP0005310_abnormal_salivary_gland1.14616749
58MP0003172_abnormal_lysosome_physiology1.05322497
59MP0003448_altered_tumor_morphology1.02481701
60MP0010094_abnormal_chromosome_stability1.01844716
61MP0001986_abnormal_taste_sensitivity1.01471750
62MP0000015_abnormal_ear_pigmentation1.00039411
63MP0002095_abnormal_skin_pigmentation0.97503747
64MP0004883_abnormal_blood_vessel0.92965788
65MP0004381_abnormal_hair_follicle0.89693651
66MP0002132_abnormal_respiratory_system0.87836469
67MP0006054_spinal_hemorrhage0.87757683
68MP0001851_eye_inflammation0.87724410
69MP0003045_fibrosis0.84966354
70MP0003077_abnormal_cell_cycle0.81603923
71MP0008004_abnormal_stomach_pH0.81147045
72MP0000604_amyloidosis0.81059329
73MP0003693_abnormal_embryo_hatching0.78013096
74MP0003690_abnormal_glial_cell0.76888092
75MP0005390_skeleton_phenotype0.76690339
76MP0001663_abnormal_digestive_system0.76284798
77MP0000343_altered_response_to0.76076002
78MP0009763_increased_sensitivity_to0.76057964
79MP0003191_abnormal_cellular_cholesterol0.75593027
80MP0008007_abnormal_cellular_replicative0.75271354
81MP0005164_abnormal_response_to0.74453975
82MP0005023_abnormal_wound_healing0.73793571
83MP0002009_preneoplasia0.73131559
84MP0003183_abnormal_peptide_metabolism0.70527518
85MP0005058_abnormal_lysosome_morphology0.70469954
86* MP0009764_decreased_sensitivity_to0.69375182
87MP0002998_abnormal_bone_remodeling0.66972081
88MP0008057_abnormal_DNA_replication0.66362348
89MP0009840_abnormal_foam_cell0.65722602
90MP0003943_abnormal_hepatobiliary_system0.65679308
91MP0003656_abnormal_erythrocyte_physiolo0.63931701
92MP0005166_decreased_susceptibility_to0.62831385
93MP0003828_pulmonary_edema0.62760943
94MP0002693_abnormal_pancreas_physiology0.61095256
95MP0010352_gastrointestinal_tract_polyps0.61092167
96MP0008058_abnormal_DNA_repair0.59238581
97* MP0000313_abnormal_cell_death0.57758766
98MP0000249_abnormal_blood_vessel0.53992120
99MP0000477_abnormal_intestine_morphology0.53970921
100MP0008874_decreased_physiological_sensi0.53845448
101MP0003091_abnormal_cell_migration0.52593081
102MP0002138_abnormal_hepatobiliary_system0.50984364
103MP0003566_abnormal_cell_adhesion0.50301293
104MP0003279_aneurysm0.48242885
105MP0002332_abnormal_exercise_endurance0.48007208
106MP0004130_abnormal_muscle_cell0.47701413
107MP0005076_abnormal_cell_differentiation0.47595414
108MP0008873_increased_physiological_sensi0.47424826
109MP0003221_abnormal_cardiomyocyte_apopto0.47261546
110MP0003795_abnormal_bone_structure0.47018226
111MP0002254_reproductive_system_inflammat0.46558607
112MP0005381_digestive/alimentary_phenotyp0.46086697
113* MP0009765_abnormal_xenobiotic_induced0.45730492
114MP0000609_abnormal_liver_physiology0.45420169
115MP0001191_abnormal_skin_condition0.45189758
116MP0000598_abnormal_liver_morphology0.44292079
117MP0004147_increased_porphyrin_level0.43185602
118MP0003111_abnormal_nucleus_morphology0.43134900
119MP0003806_abnormal_nucleotide_metabolis0.41857272
120MP0003075_altered_response_to0.41045735
121MP0003453_abnormal_keratinocyte_physiol0.41020917

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.00665462
2Elevated erythrocyte sedimentation rate (HP:0003565)5.00169114
3Recurrent bronchitis (HP:0002837)4.89201758
4Chronic otitis media (HP:0000389)4.86959246
5IgM deficiency (HP:0002850)4.81400591
6Abnormality of T cell number (HP:0011839)4.78208275
7Myositis (HP:0100614)4.54125360
8Recurrent abscess formation (HP:0002722)4.50684669
9Eczematoid dermatitis (HP:0000976)4.46005958
10Recurrent fungal infections (HP:0002841)4.37622779
11Thrombocytosis (HP:0001894)4.26049585
12Abnormality of T cells (HP:0002843)4.22289308
13Recurrent viral infections (HP:0004429)4.21518983
14Severe combined immunodeficiency (HP:0004430)4.18548779
15Panhypogammaglobulinemia (HP:0003139)4.10548362
16Combined immunodeficiency (HP:0005387)3.92155179
17Thyroiditis (HP:0100646)3.91352995
18Recurrent cutaneous fungal infections (HP:0011370)3.75654460
19Chronic mucocutaneous candidiasis (HP:0002728)3.75654460
20Recurrent bacterial skin infections (HP:0005406)3.71118256
21Nasal polyposis (HP:0100582)3.71109559
22Stomatitis (HP:0010280)3.69759148
23Agammaglobulinemia (HP:0004432)3.61613172
24Meningitis (HP:0001287)3.61308890
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.60958738
26IgG deficiency (HP:0004315)3.56443055
27Lymphopenia (HP:0001888)3.39983760
28B lymphocytopenia (HP:0010976)3.39302236
29Abnormality of B cell number (HP:0010975)3.39302236
30Abnormality of the nasal mucosa (HP:0000433)3.37910410
31Abnormality of T cell physiology (HP:0011840)3.31294013
32Pustule (HP:0200039)3.30024259
33Chronic diarrhea (HP:0002028)3.29235031
34Mediastinal lymphadenopathy (HP:0100721)3.28227680
35Recurrent skin infections (HP:0001581)3.27489348
36Abnormality of eosinophils (HP:0001879)3.26762454
37Abnormality of cells of the lymphoid lineage (HP:0012140)3.24035027
38Inflammation of the large intestine (HP:0002037)3.13194324
39Retrobulbar optic neuritis (HP:0100654)3.11634439
40Optic neuritis (HP:0100653)3.11634439
41Gastrointestinal inflammation (HP:0004386)3.09731526
42Petechiae (HP:0000967)3.09346768
43Urticaria (HP:0001025)3.08115452
44Leukocytosis (HP:0001974)3.07274958
45Vasculitis (HP:0002633)3.04946710
46Orchitis (HP:0100796)3.03232119
47Spontaneous hematomas (HP:0007420)2.99925284
48Prolonged bleeding time (HP:0003010)2.97229717
49Obstructive lung disease (HP:0006536)2.95627986
50Chronic obstructive pulmonary disease (HP:0006510)2.95627986
51Cellulitis (HP:0100658)2.92181014
52Recurrent sinusitis (HP:0011108)2.90944893
53Eosinophilia (HP:0001880)2.90456003
54Hypoplasia of the thymus (HP:0000778)2.89586844
55Epistaxis (HP:0000421)2.78453486
56Bronchitis (HP:0012387)2.78023694
57Encephalitis (HP:0002383)2.76483014
58Granulocytopenia (HP:0001913)2.74246929
59Chronic sinusitis (HP:0011109)2.70627510
60Lymphoma (HP:0002665)2.68863783
61Abnormality of the fingertips (HP:0001211)2.65817084
62Abnormality of macrophages (HP:0004311)2.63644515
63Arterial thrombosis (HP:0004420)2.62054797
64Gastrointestinal stroma tumor (HP:0100723)2.60908578
65Gangrene (HP:0100758)2.60348377
66Autoimmune thrombocytopenia (HP:0001973)2.59595388
67Increased IgE level (HP:0003212)2.57635430
68Episodic fever (HP:0001954)2.56499346
69Anorexia (HP:0002039)2.55029298
70Hemoptysis (HP:0002105)2.52743144
71Verrucae (HP:0200043)2.50068205
72Papilloma (HP:0012740)2.50068205
73IgA deficiency (HP:0002720)2.50054172
74Recurrent gram-negative bacterial infections (HP:0005420)2.49964159
75Colitis (HP:0002583)2.49742145
76Keratoconjunctivitis sicca (HP:0001097)2.46241291
77Hypochromic anemia (HP:0001931)2.46213421
78Autoimmune hemolytic anemia (HP:0001890)2.42539384
79Chest pain (HP:0100749)2.42273124
80Gingivitis (HP:0000230)2.41790296
81Pulmonary infiltrates (HP:0002113)2.38691210
82Abnormality of the pleura (HP:0002103)2.38210722
83Abnormality of the prostate (HP:0008775)2.33084013
84Gingival bleeding (HP:0000225)2.32290532
85Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.28873756
86Hypergammaglobulinemia (HP:0010702)2.28323711
87Joint swelling (HP:0001386)2.28245346
88Periodontitis (HP:0000704)2.27527516
89Amaurosis fugax (HP:0100576)2.25182476
90Aplastic anemia (HP:0001915)2.24051454
91Interstitial pulmonary disease (HP:0006530)2.23905345
92Basal cell carcinoma (HP:0002671)2.23894393
93Keratoconjunctivitis (HP:0001096)2.20493285
94Slow saccadic eye movements (HP:0000514)2.19009288
95Skin ulcer (HP:0200042)2.13696879
96Hypochromic microcytic anemia (HP:0004840)2.13553390
97Abnormality of liposaccharide metabolism (HP:0010968)2.12700242
98Abnormality of glycosphingolipid metabolism (HP:0004343)2.12700242
99Abnormality of glycolipid metabolism (HP:0010969)2.12700242
100Abnormal platelet function (HP:0011869)2.10702481
101Impaired platelet aggregation (HP:0003540)2.10702481
102Glomerulopathy (HP:0100820)2.10368311
103Gastrointestinal infarctions (HP:0005244)2.09943124
104Abnormal platelet volume (HP:0011876)2.08804471
105Increased cerebral lipofuscin (HP:0011813)2.07057273
106Poikiloderma (HP:0001029)2.06085132
107Sepsis (HP:0100806)2.05659300
108Fatigue (HP:0012378)2.04231547
109Keratitis (HP:0000491)2.03675916
110Polyneuropathy (HP:0001271)2.03572037
111Acute hepatic failure (HP:0006554)2.02766979
112Increased IgM level (HP:0003496)2.02496541
113Increased serum ferritin (HP:0003281)2.00334834
114Skin rash (HP:0000988)1.99637276
115Premature loss of primary teeth (HP:0006323)1.99007475
116Emphysema (HP:0002097)1.96456617
117Restrictive lung disease (HP:0002091)1.96435383
118Osteomyelitis (HP:0002754)1.95049788
119Loss of speech (HP:0002371)1.94003020
120Pulmonary embolism (HP:0002204)1.93326581
121Acute myeloid leukemia (HP:0004808)1.93243683
122Papilledema (HP:0001085)1.92763125
123Abnormal number of erythroid precursors (HP:0012131)1.92333280
124Amyloidosis (HP:0011034)1.91816332

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.49345758
2TXK4.43904050
3JAK33.36807376
4ZAP702.98896083
5PRPF4B2.91615121
6BTK2.54682001
7BLK2.40898470
8TEC2.39199821
9KIT2.38743871
10ITK2.35580727
11TYK22.23757101
12STK102.22865497
13IKBKE2.05514919
14SYK2.05352076
15NME22.03577193
16EEF2K1.94101131
17IRAK41.85969012
18TBK11.81183108
19MAP3K141.80458284
20GRK61.79786133
21CSF1R1.76756633
22LCK1.73034107
23JAK11.71769964
24NLK1.62067468
25FGFR41.60593011
26MAP3K121.50724594
27TGFBR21.50267311
28HCK1.45587090
29FLT31.44747259
30FES1.43135850
31MAP3K31.40796054
32KDR1.39908071
33FGR1.39120361
34CSK1.30319052
35MAP3K101.29241712
36PKN21.28636819
37MAP2K31.27766874
38BMPR21.23912305
39CLK11.19619433
40IKBKB1.17591433
41LRRK21.17005803
42LYN1.16689186
43MAP3K11.16429764
44FGFR31.15559935
45PIM11.15521270
46MAP3K131.14427224
47TAOK31.11778629
48TAOK21.04119323
49MARK31.02877101
50IRAK11.01815960
51RIPK40.95536773
52TNK20.95501702
53TGFBR10.88950082
54JAK20.88740817
55PIM20.86547286
56RPS6KA40.79345168
57KSR20.78154522
58SIK30.78011176
59IRAK20.77911147
60SIK20.76621610
61YES10.75825812
62TESK20.75565172
63CAMKK20.74971890
64IRAK30.74897854
65MAPK70.72288870
66PRKCQ0.71798976
67CDC42BPA0.69201097
68CHUK0.67641309
69MAP3K110.64617856
70CDK40.64610051
71CAMKK10.63315199
72ERN10.63208831
73EPHB10.62557017
74GRK70.62349446
75PDK10.61430718
76SMG10.61369042
77MST40.59794243
78PRKD20.59702580
79MAP3K70.57366742
80MAPK40.55801873
81NEK90.54499474
82RAF10.54495262
83PIK3CG0.54480935
84MATK0.52679925
85RPS6KB20.52456578
86HIPK20.51181773
87PDPK10.50351101
88CDK120.50235629
89PRKCH0.48468124
90TAOK10.48429747
91MAPK110.48099438
92STK40.46310139
93PTK60.45691777
94MAPKAPK30.43480483
95RPS6KA60.43464708
96CDC70.41800164
97STK240.41795240
98TRPM70.41596099
99MAP3K50.41354597
100MAP2K60.41174601
101MAP3K80.39448160
102CDK90.38538305
103MAPKAPK20.37595216
104SGK30.36337513
105STK110.35179069
106MAP3K20.35055427
107MAP2K20.34844501
108PASK0.34731445
109EPHA30.34242461
110SIK10.33659906
111MAPK120.33316344
112TRIB30.33269721
113PRKCD0.33204811
114RPS6KC10.32584095
115RPS6KL10.32584095
116RET0.31621405
117FYN0.29988731
118VRK10.29770188
119MAPK30.29557043
120ABL10.28860279
121CDK60.28739465
122DYRK1B0.28139848
123NUAK10.27410041
124SCYL20.26126362
125MARK20.26003327
126CDK190.25780980
127NEK20.24986008
128CDK80.24565165
129MYLK0.24403361
130IGF1R0.23788508

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.12557426
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.89013277
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.75080909
4T cell receptor signaling pathway_Homo sapiens_hsa046602.73743357
5B cell receptor signaling pathway_Homo sapiens_hsa046622.59624617
6Measles_Homo sapiens_hsa051622.56226638
7Antigen processing and presentation_Homo sapiens_hsa046122.55146087
8Leishmaniasis_Homo sapiens_hsa051402.51461443
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.46126847
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.44974565
11Hematopoietic cell lineage_Homo sapiens_hsa046402.34467302
12Osteoclast differentiation_Homo sapiens_hsa043802.12159609
13DNA replication_Homo sapiens_hsa030301.97782856
14Graft-versus-host disease_Homo sapiens_hsa053321.96331943
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86871204
16Allograft rejection_Homo sapiens_hsa053301.80039164
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.79228879
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74682918
19Ribosome_Homo sapiens_hsa030101.69164654
20Herpes simplex infection_Homo sapiens_hsa051681.64835084
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.64245679
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59359349
23Acute myeloid leukemia_Homo sapiens_hsa052211.53918953
24Shigellosis_Homo sapiens_hsa051311.42194548
25Mismatch repair_Homo sapiens_hsa034301.41750380
26Other glycan degradation_Homo sapiens_hsa005111.35349885
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35242055
28Hepatitis B_Homo sapiens_hsa051611.34537380
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34499695
30Viral myocarditis_Homo sapiens_hsa054161.31493241
31Toxoplasmosis_Homo sapiens_hsa051451.31459845
32Chemokine signaling pathway_Homo sapiens_hsa040621.27729186
33Staphylococcus aureus infection_Homo sapiens_hsa051501.26306034
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26279514
35* Leukocyte transendothelial migration_Homo sapiens_hsa046701.23555418
36Base excision repair_Homo sapiens_hsa034101.20450242
37Influenza A_Homo sapiens_hsa051641.18491608
38Platelet activation_Homo sapiens_hsa046111.15077536
39Legionellosis_Homo sapiens_hsa051341.12469513
40Apoptosis_Homo sapiens_hsa042101.11018888
41Non-homologous end-joining_Homo sapiens_hsa034501.09837632
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09828999
43Malaria_Homo sapiens_hsa051441.09196964
44Tuberculosis_Homo sapiens_hsa051521.06833430
45Pertussis_Homo sapiens_hsa051331.03980615
46Autoimmune thyroid disease_Homo sapiens_hsa053201.03215166
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97877167
48Epstein-Barr virus infection_Homo sapiens_hsa051690.97841926
49Asthma_Homo sapiens_hsa053100.97439311
50TNF signaling pathway_Homo sapiens_hsa046680.97031376
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96463609
52Phagosome_Homo sapiens_hsa041450.96265317
53Chronic myeloid leukemia_Homo sapiens_hsa052200.95590228
54Pancreatic cancer_Homo sapiens_hsa052120.95098578
55HTLV-I infection_Homo sapiens_hsa051660.93295674
56Salmonella infection_Homo sapiens_hsa051320.92644724
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91587386
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81463704
59Homologous recombination_Homo sapiens_hsa034400.80318013
60Viral carcinogenesis_Homo sapiens_hsa052030.78257823
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78064047
62Spliceosome_Homo sapiens_hsa030400.77991720
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77512962
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76076981
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74144763
66p53 signaling pathway_Homo sapiens_hsa041150.74102216
67Nucleotide excision repair_Homo sapiens_hsa034200.72989334
68Renal cell carcinoma_Homo sapiens_hsa052110.69325722
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.69271604
70Colorectal cancer_Homo sapiens_hsa052100.68300636
71Hepatitis C_Homo sapiens_hsa051600.67301301
72Prolactin signaling pathway_Homo sapiens_hsa049170.66244170
73Type I diabetes mellitus_Homo sapiens_hsa049400.63773707
74VEGF signaling pathway_Homo sapiens_hsa043700.63677319
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.63157745
76Thyroid cancer_Homo sapiens_hsa052160.62192795
77RNA degradation_Homo sapiens_hsa030180.61537517
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61033749
79Dorso-ventral axis formation_Homo sapiens_hsa043200.54044810
80Pyrimidine metabolism_Homo sapiens_hsa002400.53595799
81mTOR signaling pathway_Homo sapiens_hsa041500.51854306
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50274986
83Endometrial cancer_Homo sapiens_hsa052130.49513792
84Cell cycle_Homo sapiens_hsa041100.48805457
85* Non-small cell lung cancer_Homo sapiens_hsa052230.48615278
86African trypanosomiasis_Homo sapiens_hsa051430.47475721
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.47030728
88Pentose phosphate pathway_Homo sapiens_hsa000300.46636234
89MAPK signaling pathway_Homo sapiens_hsa040100.46373324
90Insulin resistance_Homo sapiens_hsa049310.45564373
91Choline metabolism in cancer_Homo sapiens_hsa052310.45258756
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44970619
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44583870
94Inositol phosphate metabolism_Homo sapiens_hsa005620.43814927
95Type II diabetes mellitus_Homo sapiens_hsa049300.43305223
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42175021
97Proteasome_Homo sapiens_hsa030500.41247368
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40938189
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.40800300
100Amoebiasis_Homo sapiens_hsa051460.39562142
101Notch signaling pathway_Homo sapiens_hsa043300.39413918
102Rheumatoid arthritis_Homo sapiens_hsa053230.39202623
103GnRH signaling pathway_Homo sapiens_hsa049120.39145000
104Prostate cancer_Homo sapiens_hsa052150.39032968
105Fanconi anemia pathway_Homo sapiens_hsa034600.37251702
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35752627
107Regulation of autophagy_Homo sapiens_hsa041400.33569060
108Endocytosis_Homo sapiens_hsa041440.33196391
109RNA polymerase_Homo sapiens_hsa030200.32976649
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.32702706
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31777158
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31694907
113HIF-1 signaling pathway_Homo sapiens_hsa040660.30958703
114N-Glycan biosynthesis_Homo sapiens_hsa005100.29618938
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29458403
116Small cell lung cancer_Homo sapiens_hsa052220.29097378
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28891537
118ErbB signaling pathway_Homo sapiens_hsa040120.28554707
119Sulfur relay system_Homo sapiens_hsa041220.28512692
120Lysosome_Homo sapiens_hsa041420.28222130
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28128991
122FoxO signaling pathway_Homo sapiens_hsa040680.26046993
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.24833824
124Caffeine metabolism_Homo sapiens_hsa002320.24363822
125Glioma_Homo sapiens_hsa052140.20888654
126Long-term potentiation_Homo sapiens_hsa047200.18450133

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