RASSF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.35246586
2L-phenylalanine catabolic process (GO:0006559)6.35246586
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.18187103
4L-phenylalanine metabolic process (GO:0006558)6.18187103
5aromatic amino acid family catabolic process (GO:0009074)5.79402873
6signal peptide processing (GO:0006465)5.56519238
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.32646851
8tryptophan catabolic process (GO:0006569)5.29532269
9indole-containing compound catabolic process (GO:0042436)5.29532269
10indolalkylamine catabolic process (GO:0046218)5.29532269
11kynurenine metabolic process (GO:0070189)5.11002305
12alpha-linolenic acid metabolic process (GO:0036109)5.07446237
13tryptophan metabolic process (GO:0006568)5.06224581
14cysteine metabolic process (GO:0006534)4.91180341
15urea cycle (GO:0000050)4.88970072
16urea metabolic process (GO:0019627)4.88970072
17sulfur amino acid catabolic process (GO:0000098)4.84511590
18glyoxylate metabolic process (GO:0046487)4.81280434
19bile acid biosynthetic process (GO:0006699)4.68309594
20negative regulation of fibrinolysis (GO:0051918)4.65708228
21high-density lipoprotein particle remodeling (GO:0034375)4.60559551
22lysine metabolic process (GO:0006553)4.49125171
23lysine catabolic process (GO:0006554)4.49125171
24nitrogen cycle metabolic process (GO:0071941)4.46659414
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.37541066
26regulation of fibrinolysis (GO:0051917)4.25221166
27reverse cholesterol transport (GO:0043691)4.20232422
28aromatic amino acid family metabolic process (GO:0009072)4.20066733
29regulation of triglyceride catabolic process (GO:0010896)4.18900448
30behavioral response to nicotine (GO:0035095)4.18339590
31protein carboxylation (GO:0018214)4.17453257
32peptidyl-glutamic acid carboxylation (GO:0017187)4.17453257
33L-fucose catabolic process (GO:0042355)4.14724882
34fucose catabolic process (GO:0019317)4.14724882
35L-fucose metabolic process (GO:0042354)4.14724882
36bile acid metabolic process (GO:0008206)4.14526999
37acylglycerol homeostasis (GO:0055090)4.09996966
38triglyceride homeostasis (GO:0070328)4.09996966
39homocysteine metabolic process (GO:0050667)4.02948376
40positive regulation of respiratory burst (GO:0060267)4.01382729
41negative regulation of cholesterol transport (GO:0032375)4.00057885
42negative regulation of sterol transport (GO:0032372)4.00057885
43serine family amino acid catabolic process (GO:0009071)3.98336013
44regulation of cholesterol esterification (GO:0010872)3.96918762
45complement activation, alternative pathway (GO:0006957)3.95223611
46epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.94139803
47drug catabolic process (GO:0042737)3.93005776
48bile acid and bile salt transport (GO:0015721)3.91979889
49cellular ketone body metabolic process (GO:0046950)3.90781807
50cilium or flagellum-dependent cell motility (GO:0001539)3.89756098
51plasma lipoprotein particle remodeling (GO:0034369)3.89622653
52protein-lipid complex remodeling (GO:0034368)3.89622653
53macromolecular complex remodeling (GO:0034367)3.89622653
54tyrosine metabolic process (GO:0006570)3.87306787
55phospholipid efflux (GO:0033700)3.86952379
56amino-acid betaine metabolic process (GO:0006577)3.85000208
57regulation of protein activation cascade (GO:2000257)3.84424878
58indolalkylamine metabolic process (GO:0006586)3.81758269
59alpha-amino acid catabolic process (GO:1901606)3.77911482
60drug transmembrane transport (GO:0006855)3.77128297
61response to pheromone (GO:0019236)3.76404383
62regulation of cholesterol homeostasis (GO:2000188)3.70796386
63intestinal cholesterol absorption (GO:0030299)3.70104910
64imidazole-containing compound metabolic process (GO:0052803)3.68057971
65cellular glucuronidation (GO:0052695)3.67690637
66benzene-containing compound metabolic process (GO:0042537)3.67397796
67pyrimidine nucleoside catabolic process (GO:0046135)3.64977844
68regulation of bile acid biosynthetic process (GO:0070857)3.64321745
69ethanol oxidation (GO:0006069)3.62232731
70kidney morphogenesis (GO:0060993)3.60806245
71plasma lipoprotein particle clearance (GO:0034381)3.59663745
72cilium movement (GO:0003341)3.59302426
73urate metabolic process (GO:0046415)3.56581741
74regulation of complement activation (GO:0030449)3.54307379
75cellular amino acid catabolic process (GO:0009063)3.52305498
76fatty acid beta-oxidation (GO:0006635)3.48492950
77epithelial cilium movement (GO:0003351)3.48450824
78plasma lipoprotein particle assembly (GO:0034377)3.47973420
79axoneme assembly (GO:0035082)3.46139504
80cytidine catabolic process (GO:0006216)3.44220530
81cytidine deamination (GO:0009972)3.44220530
82cytidine metabolic process (GO:0046087)3.44220530
83arginine metabolic process (GO:0006525)3.43470389
84cellular biogenic amine catabolic process (GO:0042402)3.43054707
85amine catabolic process (GO:0009310)3.43054707
86glutamate metabolic process (GO:0006536)3.42443263
87fatty acid oxidation (GO:0019395)3.41906567
88lipoprotein metabolic process (GO:0042157)3.41905947
89serine family amino acid metabolic process (GO:0009069)3.40936502
90intestinal absorption (GO:0050892)3.38762011
91phospholipid homeostasis (GO:0055091)3.38591703
92valine metabolic process (GO:0006573)3.37997836
93aldehyde catabolic process (GO:0046185)3.37660463
94cholesterol efflux (GO:0033344)3.37047446
95pyrimidine ribonucleoside catabolic process (GO:0046133)3.36587298
96complement activation, classical pathway (GO:0006958)3.36201572
97cholesterol homeostasis (GO:0042632)3.35192451
98sterol homeostasis (GO:0055092)3.34420517
99acetyl-CoA metabolic process (GO:0006084)3.33924223
100bundle of His cell to Purkinje myocyte communication (GO:0086069)3.33805776
101lipid oxidation (GO:0034440)3.33765939
102cellular modified amino acid catabolic process (GO:0042219)3.33668328
103thyroid hormone metabolic process (GO:0042403)3.31786218
104cobalamin metabolic process (GO:0009235)3.31375553
105short-chain fatty acid metabolic process (GO:0046459)3.30950649
106ketone body metabolic process (GO:1902224)3.30888952
107intestinal epithelial cell development (GO:0060576)3.30685248
108axonemal dynein complex assembly (GO:0070286)3.30474142
109coenzyme catabolic process (GO:0009109)3.30442441
110response to nitrosative stress (GO:0051409)3.29519156
111glucuronate metabolic process (GO:0019585)3.28006520
112uronic acid metabolic process (GO:0006063)3.28006520
113endocrine pancreas development (GO:0031018)3.26190045
114digestion (GO:0007586)3.25960778
115fatty acid catabolic process (GO:0009062)3.22701214
116carboxylic acid catabolic process (GO:0046395)3.22627182
117organic acid catabolic process (GO:0016054)3.22627182
118monocarboxylic acid catabolic process (GO:0072329)3.22203229
119protein-lipid complex assembly (GO:0065005)3.21856751
120glycine metabolic process (GO:0006544)3.21690286
121regulation of guanylate cyclase activity (GO:0031282)3.19665509
122reflex (GO:0060004)3.17209240
123exogenous drug catabolic process (GO:0042738)3.15628040
124phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.14276709
125nucleobase catabolic process (GO:0046113)3.13742719
126sulfate transmembrane transport (GO:1902358)3.08792580
127serotonin metabolic process (GO:0042428)3.07280819
128negative regulation of neurological system process (GO:0031645)3.06131412
129maintenance of gastrointestinal epithelium (GO:0030277)3.06094941
130water-soluble vitamin biosynthetic process (GO:0042364)3.02457358
131sphingoid metabolic process (GO:0046519)3.01258394
132auditory receptor cell differentiation (GO:0042491)2.99471808
133negative regulation of cytosolic calcium ion concentration (GO:0051481)2.95591812
134regulation of hexokinase activity (GO:1903299)2.93337988
135regulation of glucokinase activity (GO:0033131)2.93337988
136primary amino compound metabolic process (GO:1901160)2.91788425
137indole-containing compound metabolic process (GO:0042430)2.90618404
138phosphatidylserine acyl-chain remodeling (GO:0036150)2.85969162
139positive regulation of guanylate cyclase activity (GO:0031284)2.85667867
140detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.85557626
141gamma-aminobutyric acid transport (GO:0015812)2.79675684
142nucleotide transmembrane transport (GO:1901679)2.79659194
143protein import into peroxisome matrix (GO:0016558)2.78868759
144sulfate transport (GO:0008272)2.78607239
145proline transport (GO:0015824)2.78383055
146hemidesmosome assembly (GO:0031581)2.78249254
147regulation of respiratory burst (GO:0060263)2.76057392
148phosphatidylinositol acyl-chain remodeling (GO:0036149)2.75003066
149snRNA transcription (GO:0009301)2.73765978
150thyroid hormone generation (GO:0006590)2.68316324
151calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.67810019
152negative regulation of osteoblast proliferation (GO:0033689)2.65839367
153sulfur compound transport (GO:0072348)2.63673333
154photoreceptor cell maintenance (GO:0045494)2.61445641
155rRNA catabolic process (GO:0016075)2.61019103
156positive regulation of protein homooligomerization (GO:0032464)2.60824710
157diol metabolic process (GO:0034311)2.60196319
158neuronal action potential (GO:0019228)2.59997881
159regulation of keratinocyte proliferation (GO:0010837)2.59016871
160O-glycan processing (GO:0016266)2.58849767
161keratinocyte development (GO:0003334)2.58275716
162flavonoid metabolic process (GO:0009812)2.56374944
1633-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.55461571
164purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.55461571
165behavioral response to ethanol (GO:0048149)2.53909439
166neurotransmitter metabolic process (GO:0042133)2.53618998
167detection of light stimulus involved in visual perception (GO:0050908)2.52001621
168detection of light stimulus involved in sensory perception (GO:0050962)2.52001621
169sphingosine metabolic process (GO:0006670)2.47690259
170sulfation (GO:0051923)2.47594717
171cilium organization (GO:0044782)2.47525806
172positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.46528730
173protein localization to cilium (GO:0061512)2.45422690
174phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.45355315
175negative regulation of bone resorption (GO:0045779)2.44059578
176transepithelial transport (GO:0070633)2.43907274
177DNA deamination (GO:0045006)2.43485173
178phosphatidylcholine acyl-chain remodeling (GO:0036151)2.41428638
179negative regulation of keratinocyte proliferation (GO:0010839)2.41026981
180desmosome organization (GO:0002934)2.40710893
181CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.40320012
182positive regulation of glycolytic process (GO:0045821)2.39139157

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.27469057
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.87530586
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.09777241
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.42253874
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.41085800
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.76954336
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.87479757
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.79731458
9* FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.75464894
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.29396094
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.07798216
12ZNF274_21170338_ChIP-Seq_K562_Hela2.92777202
13VDR_22108803_ChIP-Seq_LS180_Human2.70721150
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.56394649
15CLOCK_20551151_ChIP-Seq_293T_Human2.53303413
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.44265383
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.42574100
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42564128
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30028773
20* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25980594
21GBX2_23144817_ChIP-Seq_PC3_Human2.25509520
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.24611488
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.18492320
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12859512
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06678993
26SOX2_27498859_Chip-Seq_STOMACH_Mouse2.05980344
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.98187493
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97827122
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95439656
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93821138
31* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.93672081
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.93516544
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89178402
34EZH2_22144423_ChIP-Seq_EOC_Human1.84843068
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.83999617
36* GATA4_25053715_ChIP-Seq_YYC3_Human1.83618730
37FUS_26573619_Chip-Seq_HEK293_Human1.80721749
38* P300_19829295_ChIP-Seq_ESCs_Human1.79667066
39IGF1R_20145208_ChIP-Seq_DFB_Human1.73402762
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.71489512
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71270502
42* STAT3_23295773_ChIP-Seq_U87_Human1.68787022
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65732364
44TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.65192495
45FOXA2_19822575_ChIP-Seq_HepG2_Human1.63293138
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.58560333
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58468178
48EWS_26573619_Chip-Seq_HEK293_Human1.57022153
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55554183
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55511225
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55393017
52CBP_20019798_ChIP-Seq_JUKART_Human1.55393017
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54606546
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.54217142
55* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54085889
56* SOX2_20726797_ChIP-Seq_SW620_Human1.53698061
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53294870
58ER_23166858_ChIP-Seq_MCF-7_Human1.51272475
59AR_25329375_ChIP-Seq_VCAP_Human1.48620661
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46978538
61SMAD4_21799915_ChIP-Seq_A2780_Human1.46938142
62TCF4_23295773_ChIP-Seq_U87_Human1.44133059
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43739401
64TAF15_26573619_Chip-Seq_HEK293_Human1.42104668
65* TCF4_22108803_ChIP-Seq_LS180_Human1.41528440
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39028936
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38151205
68* FOXO3_23340844_ChIP-Seq_DLD1_Human1.38041937
69* HNF4A_19822575_ChIP-Seq_HepG2_Human1.37665616
70GATA1_22025678_ChIP-Seq_K562_Human1.37649759
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37087531
72CDX2_20551321_ChIP-Seq_CACO-2_Human1.36808835
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36476445
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.36265868
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35406777
76P53_22387025_ChIP-Seq_ESCs_Mouse1.35012988
77SOX2_19829295_ChIP-Seq_ESCs_Human1.33584649
78NANOG_19829295_ChIP-Seq_ESCs_Human1.33584649
79* SMAD3_21741376_ChIP-Seq_EPCs_Human1.32340319
80TP53_16413492_ChIP-PET_HCT116_Human1.31818510
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.31177697
82AHR_22903824_ChIP-Seq_MCF-7_Human1.30528990
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.29893474
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29848491
85P300_18555785_Chip-Seq_ESCs_Mouse1.28343318
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.27239378
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27239378
88* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26881047
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.25694655
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25044318
91GATA6_25053715_ChIP-Seq_YYC3_Human1.24568475
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.24401112
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23902521
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.23688457
95PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23654395
96TP53_22573176_ChIP-Seq_HFKS_Human1.22990462
97E2F1_18555785_Chip-Seq_ESCs_Mouse1.22310441
98* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22140066
99SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21794540
100SALL1_21062744_ChIP-ChIP_HESCs_Human1.19047197
101* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18006176
102OCT4_18555785_Chip-Seq_ESCs_Mouse1.17243124
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16774165
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16774165
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.14958254
106SOX2_18555785_Chip-Seq_ESCs_Mouse1.14641350
107RUNX2_22187159_ChIP-Seq_PCA_Human1.14581221
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12613792
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.12416190
110TP53_18474530_ChIP-ChIP_U2OS_Human1.12007646
111AR_21572438_ChIP-Seq_LNCaP_Human1.11931637
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10996062
113ETV1_20927104_ChIP-Seq_GIST48_Human1.10051492
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09994309
115CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09672601
116HOXB7_26014856_ChIP-Seq_BT474_Human1.09620166
117CTCF_18555785_Chip-Seq_ESCs_Mouse1.09172845
118NMYC_18555785_Chip-Seq_ESCs_Mouse1.08838008
119SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08247643
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.07551929
121SMRT_27268052_Chip-Seq_Bcells_Human1.07131640
122FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.05673945
123SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05043509
124FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04006513
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99793715
126IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98685972
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98103324
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96867581
129GATA3_24758297_ChIP-Seq_MCF-7_Human0.96080035
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92548663
131ZNF263_19887448_ChIP-Seq_K562_Human0.91199055
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90704014
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87515497
134* FOXA1_25552417_ChIP-Seq_VCAP_Human0.86717097
135SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86232647
136SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86232647
137* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85636773
138* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85636773
139CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82879251
140TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82225358
141GATA2_21666600_ChIP-Seq_HMVEC_Human0.81556542
142BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80369209
143KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78509767
144ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78194591
145NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78111589
146PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77148207
147ATF3_27146783_Chip-Seq_COLON_Human0.77140291
148AR_21909140_ChIP-Seq_LNCAP_Human0.76960287
149CDX2_22108803_ChIP-Seq_LS180_Human0.76680261
150TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76198314
151CJUN_26792858_Chip-Seq_BT549_Human0.75300646
152RACK7_27058665_Chip-Seq_MCF-7_Human0.74852736
153ZNF217_24962896_ChIP-Seq_MCF-7_Human0.74373153
154RXRA_24833708_ChIP-Seq_LIVER_Mouse0.73871718
155KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.69838476
156THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.69357771
157RUNX1_27514584_Chip-Seq_MCF-7_Human0.68541340
158CEBPB_22108803_ChIP-Seq_LS180_Human0.68386820
159RARA_24833708_ChIP-Seq_LIVER_Mouse0.67973180
160BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67925091
161STAT1_17558387_ChIP-Seq_HELA_Human0.67840853
162AR_20517297_ChIP-Seq_VCAP_Human0.67425840
163* TP63_23658742_ChIP-Seq_EP156T_Human0.67287864
164P63_26484246_Chip-Seq_KERATINOCYTES_Human0.66269478
165HIF1A_21447827_ChIP-Seq_MCF-7_Human0.65534020
166HTT_18923047_ChIP-ChIP_STHdh_Human0.65144660
167STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.64946953
168NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64916646
169GATA2_19941826_ChIP-Seq_K562_Human0.64409198
170FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.64360975
171ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.63947060
172TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.63873604
173PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.62677309
174ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.62476527
175FOXM1_26456572_ChIP-Seq_MCF-7_Human0.61261105
176ESR1_15608294_ChIP-ChIP_MCF-7_Human0.60684995
177LXR_22292898_ChIP-Seq_THP-1_Human0.60446435
178PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.60033800
179BCAT_22108803_ChIP-Seq_LS180_Human0.59835058
180* ERG_20517297_ChIP-Seq_VCAP_Human0.59216196
181SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.57507377
182JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57353820

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.67815777
2MP0005360_urolithiasis6.32871916
3MP0005085_abnormal_gallbladder_physiolo5.39805514
4MP0005365_abnormal_bile_salt5.00066539
5MP0004147_increased_porphyrin_level4.22214480
6MP0008875_abnormal_xenobiotic_pharmacok3.86417193
7MP0003252_abnormal_bile_duct3.63681405
8MP0002254_reproductive_system_inflammat3.25661223
9MP0003806_abnormal_nucleotide_metabolis3.23503781
10MP0003195_calcinosis3.02570422
11MP0010329_abnormal_lipoprotein_level2.92647032
12MP0001666_abnormal_nutrient_absorption2.80094677
13MP0005645_abnormal_hypothalamus_physiol2.60522105
14MP0005332_abnormal_amino_acid2.58883115
15MP0005083_abnormal_biliary_tract2.45904065
16MP0010234_abnormal_vibrissa_follicle2.37394165
17MP0002138_abnormal_hepatobiliary_system2.35991217
18MP0002909_abnormal_adrenal_gland2.35874242
19MP0009840_abnormal_foam_cell2.22041603
20MP0010386_abnormal_urinary_bladder2.21826763
21MP0004019_abnormal_vitamin_homeostasis2.16020154
22MP0000383_abnormal_hair_follicle1.99931903
23MP0000609_abnormal_liver_physiology1.97713280
24MP0008872_abnormal_physiological_respon1.95527518
25MP0009643_abnormal_urine_homeostasis1.91365083
26MP0002876_abnormal_thyroid_physiology1.88057421
27MP0002118_abnormal_lipid_homeostasis1.78751678
28MP0002735_abnormal_chemical_nociception1.78153587
29MP0001348_abnormal_lacrimal_gland1.76517353
30MP0004264_abnormal_extraembryonic_tissu1.74912869
31MP0003183_abnormal_peptide_metabolism1.74523970
32MP0003868_abnormal_feces_composition1.69939697
33MP0008877_abnormal_DNA_methylation1.68962881
34MP0004885_abnormal_endolymph1.61703737
35MP0005310_abnormal_salivary_gland1.55240333
36MP0005319_abnormal_enzyme/_coenzyme1.54396913
37MP0003705_abnormal_hypodermis_morpholog1.52084480
38MP0009046_muscle_twitch1.47845139
39MP0004043_abnormal_pH_regulation1.47059330
40MP0001501_abnormal_sleep_pattern1.45716493
41MP0003191_abnormal_cellular_cholesterol1.45013415
42MP0002163_abnormal_gland_morphology1.44864973
43MP0005551_abnormal_eye_electrophysiolog1.42710074
44MP0002822_catalepsy1.42419846
45MP0008057_abnormal_DNA_replication1.41854851
46MP0005220_abnormal_exocrine_pancreas1.39798490
47MP0001764_abnormal_homeostasis1.39294772
48MP0004782_abnormal_surfactant_physiolog1.38756497
49MP0003787_abnormal_imprinting1.37873249
50MP0001485_abnormal_pinna_reflex1.35320194
51MP0002277_abnormal_respiratory_mucosa1.30959747
52MP0003045_fibrosis1.30004400
53MP0003866_abnormal_defecation1.28014426
54MP0001881_abnormal_mammary_gland1.27104507
55MP0001986_abnormal_taste_sensitivity1.26273744
56MP0001664_abnormal_digestion1.26089183
57MP0003890_abnormal_embryonic-extraembry1.23506974
58MP0002102_abnormal_ear_morphology1.21818993
59MP0005584_abnormal_enzyme/coenzyme_acti1.20251366
60MP0001756_abnormal_urination1.19392168
61MP0009697_abnormal_copulation1.18684272
62MP0000631_abnormal_neuroendocrine_gland1.15977216
63MP0005636_abnormal_mineral_homeostasis1.15839876
64MP0001188_hyperpigmentation1.15768149
65MP0000685_abnormal_immune_system1.14964476
66MP0002234_abnormal_pharynx_morphology1.12874896
67MP0001984_abnormal_olfaction1.10796056
68MP0003300_gastrointestinal_ulcer1.09430810
69MP0000598_abnormal_liver_morphology1.07052951
70MP0003186_abnormal_redox_activity1.06204089
71MP0005451_abnormal_body_composition1.05434111
72MP0002166_altered_tumor_susceptibility1.05378773
73MP0009745_abnormal_behavioral_response1.04092285
74MP0003283_abnormal_digestive_organ1.03585361
75MP0000538_abnormal_urinary_bladder1.02859133
76MP0000566_synostosis1.02786451
77MP0000470_abnormal_stomach_morphology1.02336716
78MP0006072_abnormal_retinal_apoptosis1.01354277
79MP0002796_impaired_skin_barrier1.00959051
80MP0005084_abnormal_gallbladder_morpholo1.00503964
81MP0001800_abnormal_humoral_immune1.00423708
82MP0003718_maternal_effect1.00068077
83MP0004924_abnormal_behavior0.99027977
84MP0005386_behavior/neurological_phenoty0.99027977
85MP0002136_abnormal_kidney_physiology0.98250704
86MP0001346_abnormal_lacrimal_gland0.98122024
87MP0005671_abnormal_response_to0.96156921
88MP0005075_abnormal_melanosome_morpholog0.95951872
89MP0002877_abnormal_melanocyte_morpholog0.95491796
90MP0002078_abnormal_glucose_homeostasis0.92224154
91MP0009384_cardiac_valve_regurgitation0.91580381
92MP0005408_hypopigmentation0.89146820
93MP0002272_abnormal_nervous_system0.88754478
94MP0005389_reproductive_system_phenotype0.87480302
95MP0001970_abnormal_pain_threshold0.87249131
96MP0000467_abnormal_esophagus_morphology0.86372626
97MP0003646_muscle_fatigue0.86239313
98MP0002557_abnormal_social/conspecific_i0.85996115
99MP0001873_stomach_inflammation0.85077543
100MP0005647_abnormal_sex_gland0.83749439
101MP0003453_abnormal_keratinocyte_physiol0.83228711
102MP0002638_abnormal_pupillary_reflex0.82831617
103MP0005379_endocrine/exocrine_gland_phen0.81569037
104MP0001919_abnormal_reproductive_system0.81433702
105MP0006276_abnormal_autonomic_nervous0.80837061
106MP0003011_delayed_dark_adaptation0.79940642
107MP0004133_heterotaxia0.79909759
108MP0009642_abnormal_blood_homeostasis0.79570412
109MP0004142_abnormal_muscle_tone0.78009373
110MP0002098_abnormal_vibrissa_morphology0.77955286
111MP0009764_decreased_sensitivity_to0.77273770
112MP0001944_abnormal_pancreas_morphology0.77030644
113MP0002733_abnormal_thermal_nociception0.77001811
114MP0005253_abnormal_eye_physiology0.75942114
115MP0010352_gastrointestinal_tract_polyps0.75888902
116MP0008469_abnormal_protein_level0.75783078
117MP0002060_abnormal_skin_morphology0.75535280
118MP0002928_abnormal_bile_duct0.75123620
119MP0003941_abnormal_skin_development0.75098647
120MP0001835_abnormal_antigen_presentation0.74881997
121MP0001765_abnormal_ion_homeostasis0.74276565
122MP0008789_abnormal_olfactory_epithelium0.74137411
123MP0000579_abnormal_nail_morphology0.73786001
124MP0002006_tumorigenesis0.73780920
125MP0002971_abnormal_brown_adipose0.73244410
126MP0003879_abnormal_hair_cell0.72669502
127MP0010678_abnormal_skin_adnexa0.72591318
128MP0009763_increased_sensitivity_to0.71084456
129MP0005670_abnormal_white_adipose0.69829291
130MP0000427_abnormal_hair_cycle0.67465592
131MP0000604_amyloidosis0.66378181
132MP0006054_spinal_hemorrhage0.64402339
133MP0005376_homeostasis/metabolism_phenot0.64333625
134MP0000613_abnormal_salivary_gland0.64105346
135MP0001853_heart_inflammation0.63314724
136MP0000013_abnormal_adipose_tissue0.61591954
137MP0000003_abnormal_adipose_tissue0.59989159
138MP0002693_abnormal_pancreas_physiology0.57529015
139MP0005448_abnormal_energy_balance0.57482682
140MP0003959_abnormal_lean_body0.57211854
141MP0010155_abnormal_intestine_physiology0.57074873
142MP0009053_abnormal_anal_canal0.57035410
143MP0004947_skin_inflammation0.56879346
144MP0005334_abnormal_fat_pad0.56381386
145MP0005666_abnormal_adipose_tissue0.55449619
146MP0001845_abnormal_inflammatory_respons0.55211728
147MP0006036_abnormal_mitochondrial_physio0.55195039
148MP0005023_abnormal_wound_healing0.54110511
149MP0009765_abnormal_xenobiotic_induced0.53111547
150MP0002168_other_aberrant_phenotype0.50871472
151MP0005501_abnormal_skin_physiology0.50651602
152MP0001790_abnormal_immune_system0.50159403
153MP0005387_immune_system_phenotype0.50159403
154MP0003566_abnormal_cell_adhesion0.49937819
155MP0005266_abnormal_metabolism0.49662080
156MP0003953_abnormal_hormone_level0.49308420
157MP0001216_abnormal_epidermal_layer0.48840180
158MP0005395_other_phenotype0.48830466
159MP0001661_extended_life_span0.48249777
160MP0009785_altered_susceptibility_to0.47283110

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.20660200
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.12376445
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.48564283
4Deep venous thrombosis (HP:0002625)5.27532686
5Hypobetalipoproteinemia (HP:0003563)5.26270538
6Xanthomatosis (HP:0000991)5.05381906
7Abnormality of glutamine family amino acid metabolism (HP:0010902)5.04320394
8Hypoglycemic coma (HP:0001325)4.65523850
9Prolonged partial thromboplastin time (HP:0003645)4.56306212
10Abnormality of proline metabolism (HP:0010907)4.10869067
11Hydroxyprolinuria (HP:0003080)4.10869067
12Hypolipoproteinemia (HP:0010981)3.98396637
13Epidermoid cyst (HP:0200040)3.91136933
14Hyperammonemia (HP:0001987)3.87094020
15Fat malabsorption (HP:0002630)3.81121728
16Abnormality of purine metabolism (HP:0004352)3.79937534
17Ketosis (HP:0001946)3.68237366
18Hyperlipoproteinemia (HP:0010980)3.64075925
19Hyperglycinuria (HP:0003108)3.62153666
20Abnormality of fatty-acid metabolism (HP:0004359)3.59842342
21Abnormality of the intrinsic pathway (HP:0010989)3.59587079
22Conjugated hyperbilirubinemia (HP:0002908)3.55418815
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.53604013
24Abnormality of the common coagulation pathway (HP:0010990)3.48230451
25Decreased circulating renin level (HP:0003351)3.48039720
26Right ventricular cardiomyopathy (HP:0011663)3.41852543
27Hypoalphalipoproteinemia (HP:0003233)3.37025442
28Chronic hepatic failure (HP:0100626)3.36061971
29Abnormality of nucleobase metabolism (HP:0010932)3.35680588
30Complement deficiency (HP:0004431)3.35429253
31Pancreatic cysts (HP:0001737)3.31330527
32Ketoacidosis (HP:0001993)3.30928297
33Gout (HP:0001997)3.25960624
34Abnormality of serine family amino acid metabolism (HP:0010894)3.22747814
35Abnormality of glycine metabolism (HP:0010895)3.22747814
36Hyperglycinemia (HP:0002154)3.18763355
37Abnormality of renin-angiotensin system (HP:0000847)3.18326152
38Abnormality of aspartate family amino acid metabolism (HP:0010899)3.13348501
39Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.13139511
40Abnormality of sulfur amino acid metabolism (HP:0004339)3.09619339
41Joint hemorrhage (HP:0005261)3.07380286
42Hypoglycemic seizures (HP:0002173)3.04816230
43Increased purine levels (HP:0004368)3.03198572
44Hyperuricemia (HP:0002149)3.03198572
45Generalized aminoaciduria (HP:0002909)2.99731449
46Chronic bronchitis (HP:0004469)2.99232099
47Abnormality of the renal cortex (HP:0011035)2.98465828
48Congenital stationary night blindness (HP:0007642)2.93925457
49Molar tooth sign on MRI (HP:0002419)2.92203367
50Abnormality of midbrain morphology (HP:0002418)2.92203367
51Bronchiectasis (HP:0002110)2.88762752
52Alkalosis (HP:0001948)2.86683147
53Malnutrition (HP:0004395)2.83147280
54Pancreatic fibrosis (HP:0100732)2.81939272
55Hyperbilirubinemia (HP:0002904)2.81834575
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.80257559
57Vascular calcification (HP:0004934)2.78660246
58Dynein arm defect of respiratory motile cilia (HP:0012255)2.77802636
59Absent/shortened dynein arms (HP:0200106)2.77802636
60Tubular atrophy (HP:0000092)2.77550756
61Hypercholesterolemia (HP:0003124)2.77349541
62Recurrent sinusitis (HP:0011108)2.76986805
63True hermaphroditism (HP:0010459)2.75827060
64Abnormal pancreas size (HP:0012094)2.74594680
65Hyperactive renin-angiotensin system (HP:0000841)2.69901734
66Abnormal respiratory motile cilium morphology (HP:0005938)2.66255966
67Abnormal respiratory epithelium morphology (HP:0012253)2.66255966
68Hyperinsulinemic hypoglycemia (HP:0000825)2.65811401
69Abnormality of methionine metabolism (HP:0010901)2.64271706
70Abnormality of chloride homeostasis (HP:0011422)2.64093370
71Abnormality of the renal medulla (HP:0100957)2.63874069
72Proximal tubulopathy (HP:0000114)2.63492459
73Steatorrhea (HP:0002570)2.61018540
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.60747084
75Dicarboxylic aciduria (HP:0003215)2.60747084
76Nephronophthisis (HP:0000090)2.59509328
77Skin nodule (HP:0200036)2.58022791
78Hyperglycemia (HP:0003074)2.58003955
79Spontaneous abortion (HP:0005268)2.56167742
80Gaze-evoked nystagmus (HP:0000640)2.54794060
81Hyperventilation (HP:0002883)2.53339466
82Esophageal varix (HP:0002040)2.52438447
83Hepatocellular carcinoma (HP:0001402)2.52407969
84Hyperaldosteronism (HP:0000859)2.50469524
85Abnormal respiratory motile cilium physiology (HP:0012261)2.50101426
86Hypokalemic alkalosis (HP:0001949)2.49957723
87Abnormality of complement system (HP:0005339)2.49738558
88Cardiovascular calcification (HP:0011915)2.49253785
89Abnormal ciliary motility (HP:0012262)2.49119765
90Bronchitis (HP:0012387)2.48576276
91Large for gestational age (HP:0001520)2.48045663
92Chronic diarrhea (HP:0002028)2.47450525
93Abnormality of pyrimidine metabolism (HP:0004353)2.47166696
94Rhinitis (HP:0012384)2.46731182
95Metabolic acidosis (HP:0001942)2.43081304
96Symptomatic seizures (HP:0011145)2.42640473
97Myocardial infarction (HP:0001658)2.41917053
98Plantar hyperkeratosis (HP:0007556)2.41348475
99Hypoplasia of the uterus (HP:0000013)2.38412277
100Hypoplastic labia majora (HP:0000059)2.37144253
101Abnormality of vitamin B metabolism (HP:0004340)2.34282286
102Abnormality of the vitamin B12 metabolism (HP:0004341)2.33516992
103Acanthocytosis (HP:0001927)2.33302616
104Aplasia/hypoplasia of the uterus (HP:0008684)2.33210988
105Hypothermia (HP:0002045)2.30220298
106Lethargy (HP:0001254)2.29325938
107Glycosuria (HP:0003076)2.26447536
108Abnormality of urine glucose concentration (HP:0011016)2.26447536
109Abnormal gallbladder morphology (HP:0012437)2.25862944
110Spastic diplegia (HP:0001264)2.24720103
111Congenital sensorineural hearing impairment (HP:0008527)2.23548668
112Metabolic alkalosis (HP:0200114)2.22865791
113Genetic anticipation (HP:0003743)2.21138360
114Abnormal drinking behavior (HP:0030082)2.20262813
115Polydipsia (HP:0001959)2.20262813
116Irritability (HP:0000737)2.20019884
117Late onset (HP:0003584)2.15118593
118Abnormality of the labia majora (HP:0012881)2.14845201
119Recurrent bronchitis (HP:0002837)2.13750397
120Abnormality of serum amino acid levels (HP:0003112)2.11425053
121Delayed CNS myelination (HP:0002188)2.11106258
122Cystic liver disease (HP:0006706)2.10837157
123Hyperkalemia (HP:0002153)2.10089007
124Abnormality of the renal collecting system (HP:0004742)2.08767533
125Attenuation of retinal blood vessels (HP:0007843)2.08142326
126Furrowed tongue (HP:0000221)2.07917470
127Exocrine pancreatic insufficiency (HP:0001738)2.07887797
128Onycholysis (HP:0001806)2.07801841
129Ileus (HP:0002595)2.05801180
130Milia (HP:0001056)2.05302503
131Abdominal distention (HP:0003270)2.04666982
132Abnormal cartilage morphology (HP:0002763)2.02215008
133Pancreatitis (HP:0001733)2.00455224
134Abnormal enzyme/coenzyme activity (HP:0012379)1.98622566
135Decreased central vision (HP:0007663)1.97809467
136Elevated hepatic transaminases (HP:0002910)1.97280365
137Mitral stenosis (HP:0001718)1.96572929
138Cholelithiasis (HP:0001081)1.96472702
139Vomiting (HP:0002013)1.95893564
140Agammaglobulinemia (HP:0004432)1.95666392
141Agitation (HP:0000713)1.94236089
142Chronic sinusitis (HP:0011109)1.94210874
143Abolished electroretinogram (ERG) (HP:0000550)1.93477909
144Opisthotonus (HP:0002179)1.91771802
145Duplicated collecting system (HP:0000081)1.91611232
146Protuberant abdomen (HP:0001538)1.91289448
147Brushfield spots (HP:0001088)1.91058306
148Glomerulosclerosis (HP:0000096)1.89688726
149Renal salt wasting (HP:0000127)1.87278257
150Dehydration (HP:0001944)1.86828905
151Lip pit (HP:0100267)1.86590958
152Enlarged kidneys (HP:0000105)1.86053698
153Medial flaring of the eyebrow (HP:0010747)1.85979472
154Renal cortical cysts (HP:0000803)1.85106586
155Thyroiditis (HP:0100646)1.84157143
156Progressive cerebellar ataxia (HP:0002073)1.83796134
157Stomach cancer (HP:0012126)1.83665800
158Pili torti (HP:0003777)1.82373900
159Neonatal onset (HP:0003623)1.82078337
160Elevated alkaline phosphatase (HP:0003155)1.80867058
161Abnormality of alkaline phosphatase activity (HP:0004379)1.80122802
162Abnormal biliary tract morphology (HP:0012440)1.80114628
163Abnormality of macular pigmentation (HP:0008002)1.79777968
164Abnormality of the gallbladder (HP:0005264)1.79619808
165Menorrhagia (HP:0000132)1.77617849
166Methylmalonic aciduria (HP:0012120)1.77052461
167Abnormality of transition element cation homeostasis (HP:0011030)1.75966219
168Congenital, generalized hypertrichosis (HP:0004540)1.75686177
169Abnormality of endocrine pancreas physiology (HP:0012093)1.75271340
170Abnormality of the pancreatic islet cells (HP:0006476)1.75271340
171Fragile nails (HP:0001808)1.75241774
172Goiter (HP:0000853)1.75211411
173Palmoplantar hyperkeratosis (HP:0000972)1.74551124
174Broad-based gait (HP:0002136)1.74514478
175Abnormality of vitamin metabolism (HP:0100508)1.74334856
176Labial hypoplasia (HP:0000066)1.74115202
177Abnormality of renal excretion (HP:0011036)1.73677169
178Nausea (HP:0002018)1.73262677
179Cerebral edema (HP:0002181)1.72678664
180Fair hair (HP:0002286)1.72537524
181Abnormal rod and cone electroretinograms (HP:0008323)1.71804282
182Methylmalonic acidemia (HP:0002912)1.70614577
183Abnormality of potassium homeostasis (HP:0011042)1.70439969
184Hypoalbuminemia (HP:0003073)1.70245115
185Abnormal albumin level (HP:0012116)1.70245115
186Palmar hyperkeratosis (HP:0010765)1.69472319
187Abnormality of B cell number (HP:0010975)1.68929425
188Abnormal hair laboratory examination (HP:0003328)1.68546827
189Abnormality of small intestinal villus morphology (HP:0011472)1.68166494

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.01294825
2ERN13.96001411
3ACVR1B3.60157729
4BCKDK3.54802948
5WNK33.43292726
6EPHA23.25637163
7STK392.99691423
8EIF2AK32.82976919
9ADRBK22.68830414
10INSRR2.61659972
11SIK12.60491138
12PTK62.45858722
13LATS12.40032785
14TLK12.31817952
15FGFR42.26672324
16TRIM282.21322959
17STK242.07423245
18MST1R2.03971793
19CASK2.03703711
20PIK3CG1.88922803
21PTK21.84168733
22MST41.74673393
23MAP3K141.66784737
24TAOK31.63157411
25LMTK21.58184371
26TRIB31.56565378
27ERBB41.54029053
28WNK41.48921142
29FLT31.48226589
30MAPK151.45973985
31DDR21.45826344
32STK38L1.41085544
33MAP4K21.39079679
34PKN21.38069850
35ZAK1.36725785
36TESK11.31254096
37TBK11.31181486
38PRKG21.23516498
39NEK91.22982299
40PRKCI1.21491198
41BRSK21.19510116
42FER1.18812747
43EPHB21.18043025
44MAP2K21.16894385
45EPHA31.16793834
46IRAK31.14721849
47TYK21.13047440
48MET1.11028875
49EPHB11.07523252
50DYRK1B1.06983128
51MAP3K41.06756687
52NUAK11.06586554
53PINK11.05976490
54TNIK1.03655861
55MAP3K21.01206433
56SIK30.99435182
57DAPK20.98248456
58LRRK20.96406282
59MAP3K30.95117161
60OXSR10.94228220
61TGFBR10.92512329
62PRKAA20.89209641
63MAP2K10.88650843
64PRKCE0.88467931
65MAPK130.87835078
66SIK20.87790592
67ADRBK10.86255389
68MAPK110.84569789
69MAP3K90.84435771
70IRAK10.84357099
71RIPK10.82186588
72RPS6KA40.81750479
73PIK3CA0.81244422
74CAMKK20.80045652
75CHUK0.79852984
76BTK0.79592010
77RPS6KB20.79068274
78ERBB30.76788391
79CDC42BPA0.75400549
80JAK20.75367137
81PAK30.74372419
82MKNK20.74260120
83NME10.72268705
84ERBB20.72071438
85STK100.71532535
86DYRK20.70805395
87ITK0.70597833
88SCYL20.68163531
89BMPR1B0.67949613
90MAPKAPK30.67739614
91JAK30.66850470
92MAP4K10.65843379
93MAP3K70.61530851
94KIT0.61271401
95GRK60.60177949
96CSNK1A10.57139176
97TXK0.57079867
98NLK0.56865137
99IKBKE0.56015883
100PRKCH0.54613932
101FGFR20.54276305
102PDK20.54212671
103GRK10.53447951
104MAP3K120.53154403
105SGK20.53138491
106CAMK1D0.52403985
107IRAK40.52251202
108CSK0.51703202
109PRKCG0.50535187
110CSF1R0.50505996
111CDK60.50489826
112TRPM70.49985174
113MAP3K110.49576172
114SYK0.48980717
115PRKCQ0.48004750
116CAMKK10.47666539
117AKT30.46495797
118TEC0.43949081
119RPS6KA50.43884105
120MAP2K60.43286867
121PRKCZ0.43282072
122IGF1R0.42948280
123JAK10.41619852
124CSNK1G10.41034415
125ABL10.39838627
126TGFBR20.39742105
127MAPKAPK50.39699102
128RPS6KB10.38954923
129BCR0.38740200
130KDR0.38715819
131MYLK0.38130628
132SGK4940.37220886
133SGK2230.37220886
134STK110.37124322
135GSK3A0.37096038
136MAP3K100.37027212
137PRKAA10.36541700
138STK30.36081835
139CDK90.35948567
140MAP2K70.35606998
141SGK10.34922280
142PASK0.32975006
143ZAP700.32829678
144FGFR30.32311676
145MAP3K10.32242199
146IKBKB0.31864224
147PDGFRA0.31858559
148PNCK0.30730313
149PRKCA0.29916054

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.70080362
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.27692955
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.26556503
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.02361497
5Tryptophan metabolism_Homo sapiens_hsa003802.88786551
6Nitrogen metabolism_Homo sapiens_hsa009102.85705325
7Fatty acid degradation_Homo sapiens_hsa000712.65622179
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.56736218
9Arginine biosynthesis_Homo sapiens_hsa002202.55848353
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.48773591
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44218236
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.35425330
13Sulfur metabolism_Homo sapiens_hsa009202.26878441
14Phototransduction_Homo sapiens_hsa047442.26303965
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20866391
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15164673
17Peroxisome_Homo sapiens_hsa041462.13217118
18Complement and coagulation cascades_Homo sapiens_hsa046102.11821672
19Butanoate metabolism_Homo sapiens_hsa006502.10732289
20Propanoate metabolism_Homo sapiens_hsa006402.07508603
21Histidine metabolism_Homo sapiens_hsa003402.06664624
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.05733041
23Caffeine metabolism_Homo sapiens_hsa002321.99431280
24PPAR signaling pathway_Homo sapiens_hsa033201.93971833
25Fatty acid metabolism_Homo sapiens_hsa012121.90680259
26Ether lipid metabolism_Homo sapiens_hsa005651.85349637
27Chemical carcinogenesis_Homo sapiens_hsa052041.83633051
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83273428
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.76074101
30Selenocompound metabolism_Homo sapiens_hsa004501.74075514
31Phenylalanine metabolism_Homo sapiens_hsa003601.67956066
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.66522637
33Pyruvate metabolism_Homo sapiens_hsa006201.64183083
34Type I diabetes mellitus_Homo sapiens_hsa049401.62025694
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57516782
36Asthma_Homo sapiens_hsa053101.55445525
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.52012277
38beta-Alanine metabolism_Homo sapiens_hsa004101.51958959
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.49956185
40Bile secretion_Homo sapiens_hsa049761.46217915
41Fat digestion and absorption_Homo sapiens_hsa049751.44465716
42Retinol metabolism_Homo sapiens_hsa008301.43903289
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43659434
44Folate biosynthesis_Homo sapiens_hsa007901.42112846
45Taste transduction_Homo sapiens_hsa047421.41497763
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39455762
47Tyrosine metabolism_Homo sapiens_hsa003501.38894692
48Pancreatic secretion_Homo sapiens_hsa049721.38814036
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34718048
50Starch and sucrose metabolism_Homo sapiens_hsa005001.33836842
51Sphingolipid metabolism_Homo sapiens_hsa006001.29720481
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26725176
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25402608
54Allograft rejection_Homo sapiens_hsa053301.24639687
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.24474934
56Vitamin digestion and absorption_Homo sapiens_hsa049771.22489907
57Autoimmune thyroid disease_Homo sapiens_hsa053201.20797542
58Fatty acid elongation_Homo sapiens_hsa000621.19076022
59Carbon metabolism_Homo sapiens_hsa012001.16735628
60ABC transporters_Homo sapiens_hsa020101.15641927
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.11426166
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09151964
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04006291
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03520303
65Staphylococcus aureus infection_Homo sapiens_hsa051501.02371296
66Graft-versus-host disease_Homo sapiens_hsa053321.01843061
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01792460
68Insulin secretion_Homo sapiens_hsa049110.99179260
69Biosynthesis of amino acids_Homo sapiens_hsa012300.98334787
70Glutathione metabolism_Homo sapiens_hsa004800.97374433
71Serotonergic synapse_Homo sapiens_hsa047260.94436478
72Arginine and proline metabolism_Homo sapiens_hsa003300.94017712
73Fatty acid biosynthesis_Homo sapiens_hsa000610.91044393
74Steroid biosynthesis_Homo sapiens_hsa001000.84837944
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81326415
76Lysine degradation_Homo sapiens_hsa003100.80368255
77Glycerolipid metabolism_Homo sapiens_hsa005610.79813326
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79259940
79Nicotine addiction_Homo sapiens_hsa050330.78425410
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76236962
81Galactose metabolism_Homo sapiens_hsa000520.70916510
82Sulfur relay system_Homo sapiens_hsa041220.70314995
83Homologous recombination_Homo sapiens_hsa034400.70117608
84Dorso-ventral axis formation_Homo sapiens_hsa043200.69719493
85Olfactory transduction_Homo sapiens_hsa047400.69480052
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65427855
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65067401
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63732664
89Pentose phosphate pathway_Homo sapiens_hsa000300.63691545
90Circadian rhythm_Homo sapiens_hsa047100.58403216
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57707929
92Ovarian steroidogenesis_Homo sapiens_hsa049130.55142508
93Fanconi anemia pathway_Homo sapiens_hsa034600.53153526
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48526843
95One carbon pool by folate_Homo sapiens_hsa006700.45664737
96Metabolic pathways_Homo sapiens_hsa011000.44787277
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44606907
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44213187
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43720526
100Linoleic acid metabolism_Homo sapiens_hsa005910.43120897
101Regulation of autophagy_Homo sapiens_hsa041400.41771577
102Salivary secretion_Homo sapiens_hsa049700.40911073
103Renin secretion_Homo sapiens_hsa049240.39668727
104Type II diabetes mellitus_Homo sapiens_hsa049300.38925145
105Basal transcription factors_Homo sapiens_hsa030220.38133020
106Non-homologous end-joining_Homo sapiens_hsa034500.37890122
107Fructose and mannose metabolism_Homo sapiens_hsa000510.37683581
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37649184
109Protein export_Homo sapiens_hsa030600.35741007
110Insulin resistance_Homo sapiens_hsa049310.31313667
111Dopaminergic synapse_Homo sapiens_hsa047280.31111250
112Amphetamine addiction_Homo sapiens_hsa050310.29914978
113Mineral absorption_Homo sapiens_hsa049780.29810937
114Oxidative phosphorylation_Homo sapiens_hsa001900.28578253
115B cell receptor signaling pathway_Homo sapiens_hsa046620.27015883
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25694431
117Glutamatergic synapse_Homo sapiens_hsa047240.25419144
118Cocaine addiction_Homo sapiens_hsa050300.25302282
119Morphine addiction_Homo sapiens_hsa050320.25002530
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.22963449
121Bladder cancer_Homo sapiens_hsa052190.22293619
122Long-term depression_Homo sapiens_hsa047300.21835407
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19598922
124RNA degradation_Homo sapiens_hsa030180.18601970
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.18506919
126GABAergic synapse_Homo sapiens_hsa047270.17637370
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.17461079
128Glucagon signaling pathway_Homo sapiens_hsa049220.16668688
129Primary immunodeficiency_Homo sapiens_hsa053400.14552634
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.14061300
131Protein digestion and absorption_Homo sapiens_hsa049740.11805561
132Arachidonic acid metabolism_Homo sapiens_hsa005900.11106963
133Thyroid hormone synthesis_Homo sapiens_hsa049180.10668622
134Vitamin B6 metabolism_Homo sapiens_hsa007500.10172443
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07127169
136Renin-angiotensin system_Homo sapiens_hsa046140.06594940
137Hepatitis C_Homo sapiens_hsa051600.02536767
138AMPK signaling pathway_Homo sapiens_hsa041520.02491778
139N-Glycan biosynthesis_Homo sapiens_hsa005100.00160201
140Prion diseases_Homo sapiens_hsa05020-0.0644358
141Antigen processing and presentation_Homo sapiens_hsa04612-0.0555228
142Legionellosis_Homo sapiens_hsa05134-0.0368907
143NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.0352323
144RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0284672
145Prolactin signaling pathway_Homo sapiens_hsa04917-0.0180074
146Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0151353
147Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0082522

Most similar genes based on co-expression Upload to Enrichr

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